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Vol. 101. Issue 3.
Pages 257-262 (April 2010)
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Vol. 101. Issue 3.
Pages 257-262 (April 2010)
Case Report
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Intralymphatic Histiocytosis and Cancer of the Colon
Histiocitosis intralinfática y neoplasia de colon
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B. Echeverría-García, R. Botella-Estrada
Corresponding author
rbotellaes@gmail.com

Corresponding author.
, C. Requena, C. Guillén
Servicio de Dermatología, Instituto Valenciano de Oncología, Valencia, Spain
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Article information
Abstract

Intralymphatic histiocytosis is a condition with nonspecific clinical features but with characteristic histopathological and immunohistochemical findings. It presents as a poorly demarcated erythematous plaque or a lesion similar to livedo reticularis, usually located on the limbs. Histologically, dilated vessels containing mononuclear cells are observed in the reticular dermis.

In the past, the majority of these cases were thought to be cases of reactive angioendotheliomatosis or intravascular lymphoma, but the development of more specific immunohistochemical markers showed that these were dilated lymph vessels containing histiocytes, and so were considered as a separate condition.

We present the case of a man with a past history of left axillary lymphadenectomy for lymphatic tuberculosis, leukocytoclastic vasculitis, and cancer of the colon. The patient developed an erythematous plaque in the left pectoral region. Histology and immunohistochemical stains of the lesion revealed histiocytes within dilated lymph vessels in the reticular dermis, but no neoplastic cells.

We present a new case of intralymphatic histiocytosis in a patient with autoimmune and neoplastic diseases.

Keywords:
Histiocytosis
Lymph vessels
Reactive angioendotheliomatosis
Intravascular lymphoma
Resumen

La histiocitosis intralinfática es una entidad de clínica inespecífica, pero con una histología y una inmunohistoquímica características. Se manifiesta como una placa eritematosa mal delimitada o una lesión livedoide que normalmente afecta a las extremidades. Histológicamente muestra vasos dilatados en la dermis reticular ocupados por células mononucleares.

Los casos descritos anteriormente se diagnosticaron de angioendoteliomatosis reactiva y de linfoma intravascular, pero el desarrollo de marcadores inmunohistoquímicos más específicos demostró que eran vasos linfáticos ocupados por histiocitos y se caracterizaron, por tanto, como una entidad propia y diferenciada.

Se presenta el caso de un varón con antecedentes de linfadenectomía axilar izquierda por una tuberculosis ganglionar, una vasculitis leucocitoclástica y una neoplasia de colon, que desarrolló una placa eritematosa en la región pectoral izquierda. En la histología y las tinciones inmunohistoquímicas se observaron histiocitos en el interior de los vasos linfáticos dilatados en la dermis reticular sin células neoplásicas.

Se presenta un nuevo caso de histiocitosis intralinfática en un paciente con enfermedad autoinmunitaria y neoplásica.

Palabras clave:
Histiocitosis
Vasos linfáticos
Angioendoteliomatosis reactiva
Linfoma intravascular
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Copyright © 2010. Academia Española de Dermatología y Venereología and Elsevier España, S.L.
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