Journal Information
Vol. 98. Issue 3.
Pages 164-170 (April 2007)
Vol. 98. Issue 3.
Pages 164-170 (April 2007)
Consensus document
Full text access
Consensus Document on Therapy With Bath Psoralen-UV-A
Documento de Consenso Sobre la Modalidad Terapéutica del Baño-Puva
Visits
7464
M.T. Rodríguez-Granadosa,
Corresponding author
Tgranados@mundo-r.com

Correspondence: Servicio de Dermatología, Complexo Hospitalario de Pontevedra.
, J.M. Carrascosab, T. Gáratec, S. Gómez-Díezd, D. Guimaraens-Juantorenae
a Servicio de Dermatología, Complexo Hospitalario de Pontevedra, Pontevedra, Spain
b Servicio de Dermatología, Hospital Universitari Germans Trias i Pujol, Badalona, Spain
c Servicio de Dermatología, Hospital Ramón y Cajal, Madrid, Spain
d Servicio de Dermatología, Hospital Universitario Central de Asturias, Spain
e Secretaria-Coordinadora del Grupo Español de Fotobiología (GEF), Spain
This item has received
Article information
Abstract
Bibliography
Download PDF
Statistics
Abstract

Bath PUVA is a variant of phototherapy as efficacious as oral PUVA therapy that avoids many of the adverse effects associated to this treatment. Nevertheless, the special features and the specialized equipment required for its employment have limited its application in the dermatologic clinics of our country. Following the trend initiated after the publication of the consensus document on oral PUVA therapy and narrow band (NB) UVB therapy, the Spanish Photobiology Group from the Spanish Academy of Dermatology and Venereology has developed a therapeutic guideline for bath PUVA therapy based on the literature review and the experience of its members. The document aims to be a practical reference guide for those dermatological centres that include phototherapy among their services. It reviews the concept and indications of this type of treatment and proposes recommendations concerning therapeutic procedures, drug associations of interest and prophylaxis and management of adverse effects.

Key words:
phototherapy
PUVA
bath PUVA
ultraviolet
Resumen

El baño-PUVA se reconoce como una variante de fototerapia tan eficaz como la terapia PUVA oral, pero que permite evitar buena parte de los efectos adversos asociados a este tratamiento. Sin embargo, las particularidades de su empleo y la necesidad de utillaje especializado han limitado su uso en los centros dermatológicos de nuestro país. En continuidad con la línea iniciada tras la publicación del documento de consenso de la terapia PUVA oral y la terapia UVB de banda estrecha (BE), el Grupo Español de Fotobiología (GEF) de la Academia Española de Dermatología y Venereología (AEDV), ha llevado a cabo la elaboración, a través de la revisión de la literatura al respecto y la experiencia propia de sus miembros, de una guía terapéutica del baño-PUVA. El documento pretende ser una guía práctica de referencia para aquellos centros dermatológicos que incluyan la fototerapia entre sus prestaciones. En él se revisan el concepto y las indicaciones de esta forma de tratamiento y se proponen recomendaciones referidas a los procedimientos terapéuticos, las asociaciones farmacológicas de interés, la prevención y el manejo de los efectos secundarios.

Palabras clave:
fototerapia
PUVA
baño-PUVA
ultravioleta
Full text is only aviable in PDF
References
[1.]
M. Kerscher, P. Lehmann, G. Plewig.
PUVA bath therapy. Indications and practical application.
Hautarzt, 45 (1994), pp. 526-528
[2.]
V. Vallat, P. Gilleaudeau, L. Battat, J. Wolfe, R. Nabeya, N. Heftler, et al.
PUVA bath therapy strongly suppresses immunological and epidermal activation in psoriasis: a possible cellular basis for remittive therapy.
J Exp Med, 180 (1994), pp. 283-296
[3.]
N. Väätäinen, M. Hannuksela, J. Karvonen.
Long-term local trioxsalen photochemotherapy in psoriasis.
Dermatology, 163 (1981), pp. 229-231
[4.]
M. Gómez, B. Pérez, A. Harto, R. De Misa, A. Ledo.
8-MOP bath PUVA in the treatment of psoriasis: Clinical results in 42 patients.
J Dermatol Treat, 7 (1996), pp. 11-12
[5.]
C. Schempp, H. Muller, W. Czech, E. Schopf, J. Simon.
Treatment of chronic palmoplantar eczema with local bath-PUVA therapy.
J Am Acad Dermatol, 36 (1997), pp. 733-737
[6.]
M. Grundmann-Kollmann, S. Behrens, R. Peter, M. Kerscher.
Treatment of severe recalcitrant dermatoses of the palms and soles with PUVA-bath versus PUVA-cream therapy.
Photodermatol Photoimmunol Photomed, 15 (1999), pp. 87-89
[7.]
S. Behrens, G. Von Kobyletzki, C. Gruss, T. Reuther, P. Altmeyer, M. Kerscher.
PUVA-bath photochemotherapy (PUVAsoak therapy) of recalcitrant dermatoses of the palms and soles.
Photodermatol Photoimmunol Photomed, 15 (1999), pp. 47-51
[8.]
A. Tanew, S. Radakovic-Fijan, M. Schemper, H. Hönigsmann.
Paired comparison study on narrow-band (TL-01) UVB phototherapy versus photochemotherapy (PUVA) in the treatment of chronic plaque type psoriasis.
Arch Dermatol, 135 (1999), pp. 519-524
[9.]
H. Hönigsmann, A. Tanew, T. Ruzicka, W. Morison.
Photo (chemo)therapy for psoriasis.
Dermatological Phototherapy and Photodiagnostic Methods, pp. 72-81
[10.]
I. Tegeder, L. Bräutigam, M. Podda, S. Meier, R. Kaufmann, G. Geisslinger, et al.
Time course of 8-methoxypsoralen concentrations in skin and plasma after topical (bath and cream) and oral administration of 8-methoxypsoralen.
Pharmacol Ther, 71 (2002), pp. 153-161
[11.]
E. Rosón, I. García Doval, A. Flórez, M. Cruces.
Estudio comparativo del tratamiento de la psoriasis en placas con baño de PUVA y UVB de banda estrecha (311 nm).
Actas Dermosifiliogr, 96 (2005), pp. 371-375
[12.]
S. Ibbotson, D. Bilsland, N. Cox, R. Dawe, B. Diffey, C. Edwards, et al.
An update and guidance on narrowband ultraviolet B phototherapy: a British Photodermatology Group Workshop Report.
Br J Dermatol, 151 (2004), pp. 283-297
[13.]
M. De Kort, H. Van Weelden.
Bath psoralen-ultraviolet A therapy in atopic eczema.
J Eur Acad Dermatol Venereol, 14 (2000), pp. 172-174
[14.]
I. Helander, C. Jansén, L. Meurman.
Long-term efficacy of PUVA treatment in lichen planus: comparison of oral and external methoxsalen regimens.
Photodermatology, 4 (1987), pp. 265-268
[15.]
M. Kerscher, M. Volkenandt, P. Lehmann, G. Plewig, M. Rocken.
PUVA-bath photochemotherapy of lichen planus.
Arch Dermatol, 131 (1995), pp. 1210-1211
[16.]
M. Kerscher, M. Meurer, C. Sander, M. Volkenandt, P. Lehmann, G. Plewig, et al.
PUVA bath photochemotherapy for localized scleroderma. Evaluation of 17 consecutive patients.
Arch Dermatol, 132 (1996), pp. 1280-1282
[17.]
A. Pasic, R. Ceovic, J. Lipozencic, K. Husar, S. Susic, M. Skerlev, et al.
Phototherapy in pediatric patients.
Pediatr Dermatol, 20 (2003), pp. 71-77
[18.]
N. Väätäinen, M. Hannuksela, J. Karvonen.
Trioxsalen baths plus UV-A in the treatment of lichen planus and urticaria pigmentosa.
Clin Exp Dermatol, 6 (1981), pp. 133-138
[19.]
O. Godt, E. Proksh, V. Streit, E. Christopher.
Short and long-term effectiveness of oral and bath-PUVA therapy in urticaria pigmentosa and systemic mastocytosis.
Dermatology, 195 (1997), pp. 35-39
[20.]
T. Fischer, M. Skough.
Treatment of parapsoriasis en plaque, mycosis fungoides and Sézary's syndrome with trioxsalen baths followed by ultraviolet light.
Acta Derm Venereol, 59 (1979), pp. 171-173
[21.]
F. Weber, M. Schmuth, N. Sepp, P. Fritsch.
Bath-water PUVA therapy with 8-methoxypsoralen in mycosis fungoides.
Acta Derm Venereol, 85 (2005), pp. 329-332
[22.]
C. Jansén, J. Karvonen, T. Malmiharju.
PUVA therapy for polymorphous light eruptions: comparison of systemic methoxsalen and topical trioxsalen regimens and evaluation of local protective mechanism.
Acta Derm Venereol, 62 (1982), pp. 317-320
[23.]
J. Carrascosa, J. Gardeazábal, A. Pérez-Ferriols, A. Alomar, P. Manrique, M. Jones-Caballero, et al.
Documento de consenso sobre fototerapia: terapias PUVA y UVB de banda estrecha.
Actas Dermosifiliogr, 96 (2005), pp. 635-658
[24.]
M. Lüftl, K. Degitz, G. Plewig, M. Röcken.
Psoralen bath plus UV-A therapy. Possibilities and limitations.
Arch Dermatol, 133 (1997), pp. 1597-1603
[25.]
T. Fischer, J. Alsins.
Treatment of psoriasis with trioxsalen baths and dysprosium lamps.
Acta Derm Venereol, 56 (1976), pp. 383-390
[26.]
M. Hannuksela, J. Karvonen.
Trioxsalen bath plus UVA effective and safe in the treatment of psoriasis.
Br J Dermatol, 99 (1978), pp. 703-707
[27.]
O. Salo, A. Lassus, J. Taskinen.
Trioxsalen bath plus UVA treatment of psoriasis. Plasma concentration of the drug and clinical results.
Acta Derm Venereol, 61 (1981), pp. 551-554
[28.]
M. Hannuksela, J. Karvonen.
Topical trioxsalen PUVA therapy.
Acta Derm Venereol, 113 (1984), pp. 135-138
[29.]
T. Coven, F. Murphy, P. Gilleaudeau, I. Cardinale, J. Krueger.
Trimethylpsoralen bath PUVA is a remittive treatment for psoriasis vulgaris. Evidence that epidermal immunocytes are direct therapeutic targets.
Arch Dermatol, 134 (1998), pp. 1263-1268
[30.]
E. Snellman, T. Rantanen.
Kinetics of phototoxicity in trioxysalen bath psoralen plus ultraviolet A photochemotherapy.
Acta Derm Venereol, 81 (2001), pp. 171-174
[31.]
L. Koulu, C. Jansén.
Skin photosensitizing and Langerhans’ cell depleting activity of topical (bath) PUVA therapy: comparison of trimethylpsoralen and 8-methoxypsoralen.
Acta Derm Venereol, 63 (1983), pp. 137-141
[32.]
N. Lowe, D. Weingarten, T. Bourget, L. Moy.
PUVA therapy for psoriasis: Comparison of oral and bath-water delivery of 8-methoxypsoralen.
J Am Acad Dermatol, 14 (1986), pp. 754-760
[33.]
P. Calzavara-Pinton, C. Zane, A. Carlino, G. de Panfilis.
Bath-5-methoxypsoralen-UVA therapy for psoriasis.
J Am Acad Dermatol, 36 (1997), pp. 945-949
[34.]
P. Collins, N. Wainwright, I. Amorim, T. Lakshmipathi, J. Ferguson.
8-MOP PUVA for psoriasis: a comparison of a minimal phototoxic dose-based regimen with a skin-type approach.
Br J Dermatol, 135 (1996), pp. 248-254
[35.]
I. Man, J. McKinlay, R. Dawe.
An intraindividual comparative study of PUVA erythema induced by bath 8 methoxypsoralen and 4,5’8 trimethylpsoralen.
J Am Acad Dermatol, 49 (2003), pp. 59-64
[36.]
C. Gruss, S. Behrens, G. Von Kobyletzki, T. Reuther, L. Husebo, P. Altmeyer, et al.
Effects of water temperature on photosensitization in bath-PUVA therapy with 8-methoxypsoralen.
Photodermatol Photoimmunol Photomed, 14 (1998), pp. 145-147
[37.]
C. Jansén.
Water temperature effect in bath-PUVA treatment.
J Am Acad Dermatol, 19 (1988), pp. 142-143
[38.]
M. Radenhausen, B. Tebbe, C. Orfanos.
Shower PUVA: a new possibility for topical PUVA therapy. Phototoxicity in relation to shower time, water temperature and skin type.
Hautarzt, 50 (1999), pp. 728-732
[39.]
M. Gómez, J. Azaña, I. Arranz, A. Harto, A. Ledo.
Plasma levels of 8-methoxypsoralen after bath-PUVA for psoriasis: relationship to disease severity.
Br J Dermatol, 133 (1995), pp. 37-40
[40.]
A. Anigbogu, A. Williams, B. Barry.
Permeation characteristics of 8-methoxypsoralen through human skin; relevance to clinical treatment.
J Pharm Pharmacol, 48 (1996), pp. 357-366
[41.]
T. Reuther, C. Gruss, S. Behrens, G. von Kobyletzki, N. Neumann, P. Lehmann, et al.
Time course of 8-methoxypsoralen-induced skin photosensitization in PUVA-bath photochemotherapy.
Photodermatol Photoimmunol Photomed, 13 (1997), pp. 193-196
[42.]
G. Von Kobyletzki, K. Hoffmann, M. Kerscher, P. Altmeyer.
Plasma levels of 8-methoxypsoralen following PUVA-bath photochemotherapy.
Photodermatol Photoimmunol Photomed, 14 (1998), pp. 136-138
[43.]
P. Calzavara-Pinton, B. Ortel, H. Honigsmann, C. Zane, G. De Panfilis.
Safety and effectiveness of an aggressive and individualized bath-PUVA regimen in the treatment of psoriasis.
Dermatology, 189 (1994), pp. 256-259
[44.]
P. Collins, S. Rogers.
Bath-water delivery of 8-methoxypsoralen therapy for psoriasis.
Clin Exp Dermatol, 16 (1991), pp. 165-167
[45.]
E. Cooper, R. Herd, G. Priestley, J. Hunter.
A comparison of bathwater and oral delivery of 8-methoxypsoralen in PUVA therapy for plaque psoriasis.
Clin Exp Dermatol, 25 (2000), pp. 111-114
[46.]
S. Al-Suwaidan, S. Feldman.
Clearance is not a realistic expectation of psoriasis treatment.
J Am Acad Dermatol, 42 (2000), pp. 796-802
[47.]
J. Lauharanta.
Photochemotherapy.
Dermatol Clin, 15 (1997), pp. 769-780
[48.]
U. Leiter, P. Kaskel, G. Krähn, P. Gottlöber, D. Bunjes, R. Peter, et al.
Psoralen plus ultraviolet-A-bath photochemotherapy as an adjunct treatment modality in cutaneous chronic graft versus host disease.
Photodermatol Photoimmunol Photomed, 18 (2002), pp. 183-190
[49.]
S. Halpern, A. Anstey, R. Dawe, B. Diffey, P. Farr, J. Ferguson, et al.
Guidelines for topical PUVA: a report of a workshop of the British Photodermatology Group.
Br J Dermatol, 142 (2000), pp. 22-31
[50.]
K. Turjanmaa, H. Salo, T. Reunala.
Comparison of trioxsalen bath and oral methoxsalen PUVA in psoriasis.
Acta Derm Venereol, 65 (1985), pp. 86-88
[51.]
S. George, J. Ferguson.
Unusual pattern of phototoxic burning following trimethylpsoralen (TMP) bath photochemotherapy (PUVA).
Br J Dermatol, 127 (1992), pp. 444-445
[52.]
T. Fischer, P. Hartvig, U. Bondesson.
Plasma concentration after bath treatment and oral administration of trioxsalen.
Acta Derm Venereol, 60 (1980), pp. 177-179
[53.]
L. Koulu, C. Jansén.
Skin phototoxicity variations during repeated bath PUVA exposures to 8-methoxypsoralen and trimethylpsoralen.
Clin Exp Dermatol, 9 (1984), pp. 64-69
[54.]
P. Calzavara-Pinton, B. Ortel, A. Carlino, H. Honigsmann, G. De Panfilis.
Phototesting and phototoxic side effects in bath PUVA.
J Am Acad Dermatol, 28 (1993), pp. 657-659
[55.]
G. Yosipovitch, A. Goon, J. Wee, Y. Chan, C. Goh.
The prevalence and clinical characteristics of pruritus among patients with extensive psoriasis.
Br J Dermatol, 143 (2000), pp. 969-973
[56.]
F. Sampogna, P. Gisondi, C. Melchi, P. Amerio, G. Girolomoni, D. Abeni.
Prevalence of symptoms experienced by patients with different clinical types of psoriasis.
Br J Dermatol, 151 (2004), pp. 594-599
[57.]
H. Hönigsmann, T. Schwarz.
Tratamiento con luz ultravioleta.
Dermatología, 1st ed., pp. 2109-2125
[58.]
S. Laube, S. George.
Adverse effects with PUVA and UVB phototherapy.
J Dermatol Treat, 12 (2001), pp. 101-105
[59.]
K. Kostovic, M. Situm, I. Nola.
Phototherapy (UVB) and photochemotherapy (PUVA) for psoriasis.
Acta Clin Croat, 41 (2002), pp. 103-112
[60.]
E. Tegner.
Severe skin pain after PUVA treatment.
Acta Derm Venereol, 59 (1979), pp. 467-470
[61.]
P. Collins, S. Rogers.
Bath-water compared with oral delivery of 8-methoxypsoralen PUVA therapy for chronic plaque psoriasis.
Br J Dermatol, 127 (1992), pp. 392-395
[62.]
N. Burrows, P. Norris.
Treatment of PUVA-induced skin pain with capsaicin.
Br J Dermatol, 131 (1994), pp. 584-585
[63.]
M. Zamiri, D. Bilsland.
Treatment of bath PUVA-induced skin pain with gabapentin.
Br J Dermatol, 151 (2004), pp. 516-517
[64.]
B. Berne, T. Fischer, G. Michaelsson, P. Noren.
Long-term safety of trioxsalen bath PUVA treatment: an 8-year follow-up of 149 psoriasis patients.
Photodermatology, 1 (1984), pp. 18-22
[65.]
A. Takashima, E. Matsunami, K. Yamamoto, S. Kitajima, N. Mizuno.
Cutaneous carcinoma and 8-methoxypsoralen and ultraviolet A (PUVA) lentigines in Japanese patients with psoriasis treated with topical PUVA: a follow-up study of 214 patients.
Photodermatol Photoimmunol Photomed, 7 (1990), pp. 218-221
[66.]
N. Cox, S. Jones, D. Downey.
Cutaneous and ocular side effects of oral photochemotherapy: result of an 8-year follow-up study.
Br J Dermatol, 116 (1987), pp. 145-152
[67.]
E. Jung, W. Obert.
PUVA lentigines.
Photodermatology, 3 (1986), pp. 46-47
[68.]
F. Vázquez-López, N. Pérez-Oliva.
Transient hyperpigmentation after calcipotriol ointment and PUVA therapy in psoriatic patients.
Acta Derm Venereol, 76 (1996), pp. 400
[69.]
R. Gläser, J. Röwert, U. Mrowietz.
Hyperpigmentation due to topical calcipotriol and photochemotherapy in two psoriatic patients.
Br J Dermatol, 139 (1998), pp. 148-151
[70.]
M. Der-Petrossian, A. Seeber, H. Honigsmann, A. Tanew.
Half-side comparison study on the efficacy of 8-methoxypsoralen bath-PUVA versus narrow-band ultraviolet B phototherapy in patients with severe chronic atopic dermatitis.
Br J Dermatol, 142 (2000), pp. 39-43
[71.]
B. Kirby, D. Buckley, S. Rogers.
Large increments in psoralenultraviolet A (PUVA) therapy are unsuitable for fair-skinned individuals with psoriasis.
Br J Dermatol, 140 (1999), pp. 661-666
[72.]
N. Väätäinen, A. Hollmen, J. Fräki.
Trimethylpsoralen bath plus ultraviolet A combined with oral retinoid (etretinate) in the treatment of severe psoriasis.
J Am Acad Dermatol, 12 (1985), pp. 52-55
[73.]
J. Lauharanta, J. Geiger.
A double-blind comparison of acitretin and etretinate in combination with bath PUVA in the treatment of extensive psoriasis.
Br J Dermatol, 121 (1989), pp. 107-112
[74.]
G. Michaelson, P. Noren, A. Vahiquist.
Combined therapy with oral retinoid and PUVA baths in severe psoriasis.
Br J Dermatol, 99 (1978), pp. 221-222
[75.]
S. Muchenberger, E. Schopf, J. Simon.
The combination of oral acitretin and bath PUVA for the treatment of severe psoriasis.
Br J Dermatol, 137 (1997), pp. 587-589
[76.]
M. Grundmann-Kollmann, J. Goethe, S. Behrens, F. Ochsendorf, R. Peter.
Treatment of psoriasis with calcipotriene plus psoralen-UV-A-bath therapy.
Arch Dermatol, 135 (1999), pp. 861-862
Copyright © 2007. Academia Española de Dermatología y Venereología and Elsevier España, S.L.
Download PDF
Idiomas
Actas Dermo-Sifiliográficas
Article options
Tools
es en

¿Es usted profesional sanitario apto para prescribir o dispensar medicamentos?

Are you a health professional able to prescribe or dispense drugs?