Información del artículo
Resumen
Los pacientes con psoriasis presentan un riesgo incrementado de accidentes cardiovasculares, y existe una correlación entre los fenómenos inmunológicos que ocurren en la psoriasis y otros procesos inflamatorios crónicos, como la ateromatosis. La aparición de eventos adversos cardiovasculares mayores en pacientes con psoriasis en placas en tratamiento con ustekinumab ha producido alarma en algunos autores; sin embargo, un análisis detallado de los estudios realizados confirma la seguridad cardiovascular de ustekinumab.
Palabras clave:
Ustekinumab
MACES
Psoriasis
Seguridad cardiovascular
Abstract
Patients with psoriasis have an increased risk of cardiovascular events, and there is evidence of a correlation between the immune processes that occur in psoriasis and those seen in other chronic inflammatory disorders such as atheromatous disease. The occurrence of major cardiovascular events in patients with plaque psoriasis being treated with ustekinumab caused alarm among some researchers, but a thorough analysis of the findings to date has confirmed the cardiovascular safety of this agent.
Keywords:
Ustekinumab
Major cardiovascular events
Psoriasis
Cardiovascular safety
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