Ustekinumab y seguridad cardiovascular
Ustekinumab and Cardiovascular Safety
J.C. Ruiz-Carrascosa
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Especialista de Área de Dermatología. Coordinador Unidad de Psoriasis. Hospital Clínico Universitario San Cecilio. Granada. España
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Hospital Clínico Universitario San Cecilio. Granada. España" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "⁎" "correspondencia" => "Autor para correspondencia." ] ] ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "Ustekinumab and Cardiovascular Safety" ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "PalabrasClave" => array:2 [ "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec85092" "palabras" => array:4 [ 0 => "Ustekinumab" 1 => "MACES" 2 => "Psoriasis" 3 => "Seguridad cardiovascular" ] ] ] "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Keywords" "identificador" => "xpalclavsec85091" "palabras" => array:4 [ 0 => "Ustekinumab" 1 => "Major cardiovascular events" 2 => "Psoriasis" 3 => "Cardiovascular safety" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "es" => array:2 [ "titulo" => "Resumen" "resumen" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Los pacientes con psoriasis presentan un riesgo incrementado de accidentes cardiovasculares, y existe una correlación entre los fenómenos inmunológicos que ocurren en la psoriasis y otros procesos inflamatorios crónicos, como la ateromatosis. La aparición de eventos adversos cardiovasculares mayores en pacientes con psoriasis en placas en tratamiento con ustekinumab ha producido alarma en algunos autores; sin embargo, un análisis detallado de los estudios realizados confirma la seguridad cardiovascular de ustekinumab.</p>" ] "en" => array:2 [ "titulo" => "Abstract" "resumen" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Patients with psoriasis have an increased risk of cardiovascular events, and there is evidence of a correlation between the immune processes that occur in psoriasis and those seen in other chronic inflammatory disorders such as atheromatous disease. The occurrence of major cardiovascular events in patients with plaque psoriasis being treated with ustekinumab caused alarm among some researchers, but a thorough analysis of the findings to date has confirmed the cardiovascular safety of this agent.</p>" ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:68 [ 0 => array:3 [ "identificador" => "bib1" "etiqueta" => "1." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Pathogenesis and clinical features of psoriasis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "C.E. Griffiths" 1 => "J.N. 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| 2022 Julio | 30 | 54 | 84 |
| 2022 Junio | 17 | 20 | 37 |
| 2022 Mayo | 23 | 32 | 55 |
| 2022 Abril | 31 | 33 | 64 |
| 2022 Marzo | 17 | 56 | 73 |
| 2022 Febrero | 17 | 39 | 56 |
| 2022 Enero | 24 | 56 | 80 |
| 2021 Diciembre | 18 | 34 | 52 |
| 2021 Noviembre | 36 | 33 | 69 |
| 2021 Octubre | 76 | 45 | 121 |
| 2021 Septiembre | 38 | 67 | 105 |
| 2021 Agosto | 27 | 35 | 62 |
| 2021 Julio | 26 | 32 | 58 |
| 2021 Junio | 22 | 25 | 47 |
| 2021 Mayo | 24 | 37 | 61 |
| 2021 Abril | 32 | 71 | 103 |
| 2021 Marzo | 24 | 19 | 43 |
| 2021 Febrero | 17 | 22 | 39 |
| 2021 Enero | 18 | 17 | 35 |
| 2020 Diciembre | 17 | 18 | 35 |
| 2020 Noviembre | 16 | 18 | 34 |
| 2020 Octubre | 22 | 15 | 37 |
| 2020 Septiembre | 6 | 8 | 14 |
| 2020 Agosto | 12 | 16 | 28 |
| 2020 Julio | 13 | 14 | 27 |
| 2020 Junio | 23 | 17 | 40 |
| 2020 Mayo | 28 | 33 | 61 |
| 2020 Abril | 17 | 17 | 34 |
| 2020 Marzo | 14 | 16 | 30 |
| 2020 Febrero | 0 | 1 | 1 |
| 2020 Enero | 0 | 1 | 1 |
| 2019 Diciembre | 0 | 1 | 1 |
| 2019 Noviembre | 0 | 5 | 5 |
| 2019 Abril | 0 | 2 | 2 |
| 2019 Febrero | 0 | 3 | 3 |
| 2018 Diciembre | 0 | 3 | 3 |
| 2018 Noviembre | 0 | 4 | 4 |
| 2018 Octubre | 0 | 1 | 1 |
| 2018 Julio | 0 | 1 | 1 |
| 2018 Junio | 0 | 3 | 3 |
| 2018 Mayo | 0 | 9 | 9 |
| 2018 Marzo | 0 | 2 | 2 |
| 2018 Febrero | 7 | 8 | 15 |
| 2018 Enero | 10 | 6 | 16 |
| 2017 Diciembre | 9 | 8 | 17 |
| 2017 Noviembre | 15 | 10 | 25 |
| 2017 Octubre | 11 | 6 | 17 |
| 2017 Septiembre | 7 | 9 | 16 |
| 2017 Agosto | 8 | 9 | 17 |
| 2017 Julio | 8 | 4 | 12 |
| 2017 Junio | 15 | 14 | 29 |
| 2017 Mayo | 14 | 17 | 31 |
| 2017 Abril | 20 | 19 | 39 |
| 2017 Marzo | 26 | 22 | 48 |
| 2017 Febrero | 12 | 18 | 30 |
| 2017 Enero | 17 | 22 | 39 |
| 2016 Diciembre | 14 | 15 | 29 |
| 2016 Noviembre | 20 | 19 | 39 |
| 2016 Octubre | 25 | 11 | 36 |
| 2016 Septiembre | 25 | 18 | 43 |
| 2016 Agosto | 36 | 19 | 55 |
| 2016 Julio | 16 | 15 | 31 |
| 2016 Junio | 0 | 4 | 4 |
| 2016 Mayo | 0 | 14 | 14 |
| 2016 Abril | 0 | 2 | 2 |
| 2016 Marzo | 0 | 4 | 4 |
| 2016 Febrero | 0 | 4 | 4 |
| 2016 Enero | 0 | 12 | 12 |
| 2015 Diciembre | 3 | 17 | 20 |
| 2015 Noviembre | 7 | 15 | 22 |
| 2015 Octubre | 8 | 21 | 29 |
| 2015 Septiembre | 6 | 14 | 20 |
| 2015 Agosto | 14 | 9 | 23 |
| 2015 Julio | 26 | 2 | 28 |
| 2015 Junio | 25 | 5 | 30 |
| 2015 Mayo | 56 | 22 | 78 |
| 2015 Abril | 34 | 17 | 51 |
| 2015 Marzo | 44 | 7 | 51 |
| 2015 Febrero | 49 | 13 | 62 |
| 2015 Enero | 35 | 14 | 49 |
| 2014 Diciembre | 35 | 9 | 44 |
| 2014 Noviembre | 33 | 16 | 49 |
| 2014 Octubre | 39 | 25 | 64 |
| 2014 Septiembre | 1 | 1 | 2 |
| 2014 Agosto | 1 | 1 | 2 |
| 2014 Mayo | 1 | 0 | 1 |
| 2014 Abril | 3 | 0 | 3 |
| 2014 Febrero | 1 | 0 | 1 |
| 2014 Enero | 0 | 1 | 1 |
| 2013 Septiembre | 0 | 1 | 1 |
| 2013 Junio | 0 | 1 | 1 |
| 2013 Mayo | 1 | 1 | 2 |
| 2013 Abril | 3 | 1 | 4 |
| 2013 Febrero | 0 | 1 | 1 |
| 2013 Enero | 0 | 1 | 1 |
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