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Vol. 99. Núm. 9.
Páginas 727-730 (noviembre 2008)
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Vol. 99. Núm. 9.
Páginas 727-730 (noviembre 2008)
Case reports
Acceso a texto completo
Two Cases of Eruptive Pyoderma Gangrenosum Associated with Cocaine Use
Piodermas Gangrenosos Eruptivos Asociados al Consumo de Cocaína Inhalada. Presentación de dos Casos
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6675
E. Roche
Autor para correspondencia
erochega@yahoo.es

Correspondence: Hospital General Universitario de Valencia, Servicio de Dermatología, Avda. Tres Cruces s/n, 46014 Valencia, Spain.
, T. Martínez-Menchón, J.L. Sánchez-Carazo, V. Oliver, V. Alegre de Miquel
Departamento de Dermatología, Hospital General Universitario de Valencia, Valencia, Spain
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Abstract

We present the cases of 2 regular cocaine users aged 30 and 37 years who developed a cutaneous condition with an identical presentation and a similar clinical course. The lesions first appeared as eruptions on the back and then spread to other parts of the body. They consisted of painful inflammatory nodules that developed into abscesses and ulcers that grew outwards. They had a granulomatous base and irregular violaceous edges. The results of histopathologic studies were compatible with the clinical diagnosis of pyoderma gangrenosum, and additional tests ruled out underlying diseases. After several therapeutic failures with usual treatments, the patients responded quickly to infliximab after interrupting their cocaine consumption. The association between pyoderma gangrenosum and cocaine use was clear as both suffered clinical relapses at the same time as they started using the drug again.

Key words:
pyoderma gangrenosum
cocaine
infliximab
Resumen

Presentamos los casos de dos pacientes varones, de 30 y 37 años, consumidores habituales de cocaína inhalada, que desarrollaron un cuadro cutáneo de idéntica presentación y evolución clínica. Las lesiones se iniciaban de forma eruptiva en la espalda y posteriormente se generalizaban. Consistían en nódulos inflamatorios y dolorosos, que evolucionaban hasta abscesos y úlceras de crecimiento centrífugo, fondo granulomatoso y bordes violáceos e irregulares. Los estudios histopatológicos fueron compatibles con los diagnósticos clínicos de piodermas gangrenosos (PG) y las exploraciones complementarias realizadas descartaron patologías subyacentes. Tras varios fracasos terapéuticos con terapias clásicas, respondieron rápidamente a infliximab asociado a deshabituación de cocaína. La asociación de PG con el consumo de cocaína quedó patente, ya que ambos mostraron recidivas clínicas simultáneamente con recaídas en su adicción.

Palabras clave:
pioderma gangrenoso
cocaína
infliximab
El Texto completo está disponible en PDF
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Copyright © 2008. Academia Española de Dermatología y Venereología and Elsevier España, S.L.
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