Case reports
Two Cases of Eruptive Pyoderma Gangrenosum Associated with Cocaine Use
Piodermas Gangrenosos Eruptivos Asociados al Consumo de Cocaína Inhalada. Presentación de dos Casos
E. Roche
, T. Martínez-Menchón, J.L. Sánchez-Carazo, V. Oliver, V. Alegre de Miquel
Autor para correspondencia
erochega@yahoo.es
Correspondence: Hospital General Universitario de Valencia, Servicio de Dermatología, Avda. Tres Cruces s/n, 46014 Valencia, Spain.
Correspondence: Hospital General Universitario de Valencia, Servicio de Dermatología, Avda. Tres Cruces s/n, 46014 Valencia, Spain.
Departamento de Dermatología, Hospital General Universitario de Valencia, Valencia, Spain
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"apellidos" => "Miranda-Romero" ] ] ] ] ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1578219008703500?idApp=UINPBA000044" "url" => "/15782190/0000009900000009/v1_201304241441/S1578219008703500/v1_201304241441/en/main.assets" ] "en" => array:14 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Case reports</span>" "titulo" => "Two Cases of Eruptive Pyoderma Gangrenosum Associated with Cocaine Use" "tieneTextoCompleto" => 0 "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "727" "paginaFinal" => "730" ] ] "autores" => array:1 [ 0 => array:4 [ "autoresLista" => "E. Roche, T. Martínez-Menchón, J.L. Sánchez-Carazo, V. Oliver, V. Alegre de Miquel" "autores" => array:5 [ 0 => array:4 [ "nombre" => "E." "apellidos" => "Roche" "email" => array:1 [ 0 => "erochega@yahoo.es" ] "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">¿</span>" "identificador" => "cor1" ] ] ] 1 => array:2 [ "nombre" => "T." "apellidos" => "Martínez-Menchón" ] 2 => array:2 [ "nombre" => "J.L." "apellidos" => "Sánchez-Carazo" ] 3 => array:2 [ "nombre" => "V." "apellidos" => "Oliver" ] 4 => array:2 [ "nombre" => "V." "apellidos" => "Alegre de Miquel" ] ] "afiliaciones" => array:1 [ 0 => array:1 [ "entidad" => "Departamento de Dermatología, Hospital General Universitario de Valencia, Valencia, Spain" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor1" "etiqueta" => "⁎" "correspondencia" => "Correspondence: Hospital General Universitario de Valencia, Servicio de Dermatología, Avda. Tres Cruces s/n, 46014 Valencia, Spain." ] ] ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Piodermas Gangrenosos Eruptivos Asociados al Consumo de Cocaína Inhalada. Presentación de dos Casos" ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaAceptado" => "2007-09-19" "PalabrasClave" => array:2 [ "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Key words" "identificador" => "xpalclavsec84306" "palabras" => array:3 [ 0 => "pyoderma gangrenosum" 1 => "cocaine" 2 => "infliximab" ] ] ] "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec84305" "palabras" => array:3 [ 0 => "pioderma gangrenoso" 1 => "cocaína" 2 => "infliximab" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "en" => array:2 [ "titulo" => "Abstract" "resumen" => "<p class="elsevierStyleSimplePara elsevierViewall">We present the cases of 2 regular cocaine users aged 30 and 37 years who developed a cutaneous condition with an identical presentation and a similar clinical course. The lesions first appeared as eruptions on the back and then spread to other parts of the body. They consisted of painful inflammatory nodules that developed into abscesses and ulcers that grew outwards. They had a granulomatous base and irregular violaceous edges. The results of histopathologic studies were compatible with the clinical diagnosis of pyoderma gangrenosum, and additional tests ruled out underlying diseases. After several therapeutic failures with usual treatments, the patients responded quickly to infliximab after interrupting their cocaine consumption. The association between pyoderma gangrenosum and cocaine use was clear as both suffered clinical relapses at the same time as they started using the drug again.</p>" ] "es" => array:2 [ "titulo" => "Resumen" "resumen" => "<p class="elsevierStyleSimplePara elsevierViewall">Presentamos los casos de dos pacientes varones, de 30 y 37 años, consumidores habituales de cocaína inhalada, que desarrollaron un cuadro cutáneo de idéntica presentación y evolución clínica. Las lesiones se iniciaban de forma eruptiva en la espalda y posteriormente se generalizaban. Consistían en nódulos inflamatorios y dolorosos, que evolucionaban hasta abscesos y úlceras de crecimiento centrífugo, fondo granulomatoso y bordes violáceos e irregulares. Los estudios histopatológicos fueron compatibles con los diagnósticos clínicos de piodermas gangrenosos (PG) y las exploraciones complementarias realizadas descartaron patologías subyacentes. Tras varios fracasos terapéuticos con terapias clásicas, respondieron rápidamente a infliximab asociado a deshabituación de cocaína. La asociación de PG con el consumo de cocaína quedó patente, ya que ambos mostraron recidivas clínicas simultáneamente con recaídas en su adicción.</p>" ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:1 [ "bibliografiaReferencia" => array:15 [ 0 => array:3 [ "identificador" => "bib1" "etiqueta" => "1." 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| 2023 Marzo | 30 | 21 | 51 |
| 2023 Febrero | 26 | 17 | 43 |
| 2023 Enero | 29 | 25 | 54 |
| 2022 Diciembre | 27 | 38 | 65 |
| 2022 Noviembre | 14 | 31 | 45 |
| 2022 Octubre | 17 | 19 | 36 |
| 2022 Septiembre | 24 | 31 | 55 |
| 2022 Agosto | 13 | 36 | 49 |
| 2022 Julio | 12 | 28 | 40 |
| 2022 Junio | 13 | 31 | 44 |
| 2022 Mayo | 32 | 45 | 77 |
| 2022 Abril | 29 | 41 | 70 |
| 2022 Marzo | 29 | 62 | 91 |
| 2022 Febrero | 22 | 33 | 55 |
| 2022 Enero | 34 | 35 | 69 |
| 2021 Diciembre | 33 | 48 | 81 |
| 2021 Noviembre | 33 | 36 | 69 |
| 2021 Octubre | 30 | 48 | 78 |
| 2021 Septiembre | 32 | 39 | 71 |
| 2021 Agosto | 24 | 22 | 46 |
| 2021 Julio | 27 | 32 | 59 |
| 2021 Junio | 38 | 36 | 74 |
| 2021 Mayo | 44 | 32 | 76 |
| 2021 Abril | 63 | 71 | 134 |
| 2021 Marzo | 73 | 23 | 96 |
| 2021 Febrero | 81 | 30 | 111 |
| 2021 Enero | 51 | 20 | 71 |
| 2020 Diciembre | 30 | 18 | 48 |
| 2020 Noviembre | 29 | 26 | 55 |
| 2020 Octubre | 48 | 16 | 64 |
| 2020 Septiembre | 32 | 18 | 50 |
| 2020 Agosto | 27 | 15 | 42 |
| 2020 Julio | 19 | 13 | 32 |
| 2020 Junio | 25 | 28 | 53 |
| 2020 Mayo | 26 | 22 | 48 |
| 2020 Abril | 18 | 25 | 43 |
| 2020 Marzo | 26 | 24 | 50 |
| 2020 Febrero | 4 | 9 | 13 |
| 2020 Enero | 0 | 10 | 10 |
| 2019 Diciembre | 0 | 13 | 13 |
| 2019 Noviembre | 0 | 4 | 4 |
| 2019 Octubre | 0 | 16 | 16 |
| 2019 Septiembre | 0 | 8 | 8 |
| 2019 Agosto | 0 | 9 | 9 |
| 2019 Julio | 0 | 19 | 19 |
| 2019 Junio | 0 | 22 | 22 |
| 2019 Mayo | 0 | 69 | 69 |
| 2019 Abril | 0 | 37 | 37 |
| 2019 Marzo | 0 | 5 | 5 |
| 2019 Febrero | 0 | 12 | 12 |
| 2019 Enero | 0 | 4 | 4 |
| 2018 Diciembre | 0 | 2 | 2 |
| 2018 Noviembre | 0 | 4 | 4 |
| 2018 Octubre | 0 | 2 | 2 |
| 2018 Septiembre | 0 | 3 | 3 |
| 2018 Agosto | 0 | 14 | 14 |
| 2018 Julio | 0 | 16 | 16 |
| 2018 Junio | 0 | 10 | 10 |
| 2018 Mayo | 0 | 8 | 8 |
| 2018 Abril | 0 | 14 | 14 |
| 2018 Marzo | 0 | 2 | 2 |
| 2018 Febrero | 6 | 11 | 17 |
| 2018 Enero | 15 | 10 | 25 |
| 2017 Diciembre | 11 | 11 | 22 |
| 2017 Noviembre | 10 | 15 | 25 |
| 2017 Octubre | 13 | 9 | 22 |
| 2017 Septiembre | 12 | 17 | 29 |
| 2017 Agosto | 14 | 14 | 28 |
| 2017 Julio | 8 | 16 | 24 |
| 2017 Junio | 13 | 20 | 33 |
| 2017 Mayo | 12 | 18 | 30 |
| 2017 Abril | 18 | 10 | 28 |
| 2017 Marzo | 18 | 73 | 91 |
| 2017 Febrero | 12 | 9 | 21 |
| 2017 Enero | 9 | 15 | 24 |
| 2016 Diciembre | 26 | 12 | 38 |
| 2016 Noviembre | 25 | 18 | 43 |
| 2016 Octubre | 31 | 21 | 52 |
| 2016 Septiembre | 35 | 10 | 45 |
| 2016 Agosto | 44 | 19 | 63 |
| 2016 Julio | 19 | 4 | 23 |
| 2016 Junio | 8 | 8 | 16 |
| 2016 Mayo | 7 | 6 | 13 |
| 2016 Abril | 9 | 9 | 18 |
| 2016 Marzo | 5 | 8 | 13 |
| 2016 Febrero | 8 | 13 | 21 |
| 2016 Enero | 5 | 10 | 15 |
| 2015 Diciembre | 8 | 10 | 18 |
| 2015 Noviembre | 12 | 5 | 17 |
| 2015 Octubre | 7 | 8 | 15 |
| 2015 Septiembre | 3 | 5 | 8 |
| 2015 Agosto | 11 | 2 | 13 |
| 2015 Julio | 30 | 13 | 43 |
| 2015 Junio | 19 | 13 | 32 |
| 2015 Mayo | 71 | 23 | 94 |
| 2015 Abril | 40 | 12 | 52 |
| 2015 Marzo | 26 | 12 | 38 |
| 2015 Febrero | 22 | 12 | 34 |
| 2015 Enero | 23 | 12 | 35 |
| 2014 Diciembre | 24 | 18 | 42 |
| 2014 Noviembre | 26 | 19 | 45 |
| 2014 Octubre | 39 | 10 | 49 |
| 2014 Septiembre | 29 | 10 | 39 |
| 2014 Agosto | 35 | 18 | 53 |
| 2014 Julio | 56 | 15 | 71 |
| 2014 Junio | 44 | 8 | 52 |
| 2014 Mayo | 35 | 14 | 49 |
| 2014 Abril | 35 | 7 | 42 |
| 2014 Marzo | 36 | 18 | 54 |
| 2014 Febrero | 22 | 20 | 42 |
| 2014 Enero | 29 | 16 | 45 |
| 2013 Diciembre | 34 | 13 | 47 |
| 2013 Noviembre | 29 | 24 | 53 |
| 2013 Octubre | 29 | 15 | 44 |
| 2013 Septiembre | 33 | 27 | 60 |
| 2013 Agosto | 32 | 27 | 59 |
| 2013 Julio | 32 | 30 | 62 |
| 2013 Junio | 24 | 21 | 45 |
| 2013 Mayo | 26 | 25 | 51 |
| 2013 Abril | 26 | 19 | 45 |
| 2013 Marzo | 28 | 30 | 58 |
| 2013 Febrero | 26 | 10 | 36 |
| 2013 Enero | 16 | 5 | 21 |
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