Información de la revista
Vol. 98. Núm. 7.
Páginas 483-485 (septiembre 2007)
Vol. 98. Núm. 7.
Páginas 483-485 (septiembre 2007)
Case reports
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Toxic Epidermal Necrolysis Induced by Phenytoin and Whole Brain Radiotherapy
Necrolisis Epidérmica Tóxica Inducida por Fenitoína y Radioterapia Holocraneal
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F.A. Fernándeza, E. Pintorb,
Autor para correspondencia
emilio.pintor@uem.es

Correspondence: Departamento de Especialidades Médicas Aplicadas. Facultad de Ciencias de la Salud. Universidad Europea de Madrid. Tajo, s/n. Villaviciosa de Odón. Madrid. Spain.
, R. Quesadaa, F.J. Garcésa
a Servicio de Medicina Interna, Hospital La Moraleja-Sanitas, Alcobendas, Madrid, Spain
b Departamento de Especialidades Médicas Aplicadas, Universidad Europea de Madrid, Spain
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Abstract

Toxic epidermal necrolysis (TEN) and Stevens-Johnson syndrome (SJS) have been associated with some drugs, particularly anticonvulsants such as phenytoin. Some authors have pointed out an increased risk of TEN/SJS when phenytoin is associated with whole brain radiotherapy. We report a patient diagnosed with breast adenocarcinoma and brain metastases that was on treatment with phenytoin and, shortly after receiving whole brain radiotherapy, developed toxic epidermal necrolysis.

Key words:
phenytoin
whole brain radiotherapy
toxic epidermal necrolysis
Stevens-Johnson syndrome
anticonvulsants
Resumen

Los cuadros de necrolisis epidérmica tóxica (NET)-síndrome de Stevens-Johnson (SSJ) se han asociado al consumo de algunos fármacos, en especial a la toma de antiepilépticos como fenitoína. Algunos autores han planteado un incremento en el riesgo de padecer NET/SSJ cuando la fenitoína se asocia con radioterapia craneal. Se presenta el caso de una paciente diagnosticada de adenocarcinoma de mama con metástasis cerebrales en tratamiento con fenitoína que poco después de recibir radioterapia cerebral presenta un cuadro de NET.

Palabras clave:
fenitoína
radioterapia holocraneal
necrolisis epidermica tóxica
síndrome de Stevens-Johnson
antiepilépticos
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Copyright © 2007. Academia Española de Dermatología y Venereología and Elsevier España, S.L.
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