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No movement or alterations of the teeth were observed&#44; nor were any other lesions detected in either the oral cavity or the cervical region&#46; Curettage of the lesion was performed&#44; followed by hemostasis with silver nitrate&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia></span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0015">Histology</span><p id="par0015" class="elsevierStylePara elsevierViewall">Histology showed fibrous tissue with prominent fusiform fibroblasts&#44; among which lamellar bone trabeculae were dispersed &#40;<a class="elsevierStyleCrossRefs" href="#fig0010">Figs&#46; 2 and 3</a>&#41;&#46; Immunohistochemistry revealed that the cell population was positive for vimentin and had a mean Ki-67 value of 23&#37;&#44; but was negative for the markers CD31&#44; CD34&#44; von Willebrand factor&#44; cytokeratin AE1&#47;AE3&#44; epithelial membrane antigen&#44; smooth muscle actin&#44; muscle-specific actin&#44; desmin&#44; CD68&#44; and S-100 protein&#46;</p><elsevierMultimedia ident="fig0010"></elsevierMultimedia><elsevierMultimedia ident="fig0015"></elsevierMultimedia><p id="par0025" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleBold">What Is Your Diagnosis&#63;</span></p></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0020">Diagnosis</span><p id="par0070" class="elsevierStylePara elsevierViewall">Peripheral cemento-ossifying fibroma &#40;PCOF&#41;&#46;</p></span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0025">Clinical Course and Treatment</span><p id="par0075" class="elsevierStylePara elsevierViewall">Two weeks after treatment the appearance of the gum had improved&#44; with no recurrence or residual lesion&#46;</p></span><span id="sec0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0030">Comment</span><p id="par0035" class="elsevierStylePara elsevierViewall">PCOF is a fibro-osseous&#44; osteogenic&#44; reactive hyperplasia&#46; Its likely origin is the multipotent cells of the periodontal ligament&#44; given its near-exclusive localization in the gums&#44; the inverse relationship between age and incidence&#44; and the presence of oxytalan fibers in the calcified matrix in some PCOF cases&#46; While the pathogenesis of PCOF is unknown&#44; this condition has been associated with trauma&#44; the presence of ectopic remnants of the periodontal ligament&#44; and the influence of female sex hormones and chronic irritants&#44; including dental calculus&#44; plaque&#44; ill-fitting dentures&#44; malpositioned teeth&#44; and irregular dental restorations&#46;<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a> Chronic irritation of the periosteum and periodontium result in the formation of reactive granulation tissue&#44; which ultimately calcifies and undergoes fibrosis&#46;<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a></p><p id="par0080" class="elsevierStylePara elsevierViewall">PCOF is rare&#44; with a higher incidence in white women in their second or third decade of life&#44; and accounts for 3&#46;1&#37; of biopsied oral tumors&#46;<a class="elsevierStyleCrossRefs" href="#bib0005"><span class="elsevierStyleSup">1&#44;2</span></a></p><p id="par0085" class="elsevierStylePara elsevierViewall">It presents as a slow-growing&#44; asymptomatic lesion in most cases&#44; although large lesions resulting in facial asymmetry or the displacement of adjacent teeth have been described&#46;<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a> Physical examination reveals a firm&#44; erythematous&#44; sessile or pedunculated tumor of normal mucosal color and of less than 2<span class="elsevierStyleHsp" style=""></span>cm in diameter&#44; located in the interdental papilla&#46;<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a> In most cases these tumors develop in the upper maxilla&#46;<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a></p><p id="par0050" class="elsevierStylePara elsevierViewall">Diagnosis is based on clinical-radiologic-pathologic correlation&#46;<a class="elsevierStyleCrossRef" href="#bib0020"><span class="elsevierStyleSup">4</span></a> Histologically&#44; PCOF is a nonencapsulated lesion composed of connective tissue&#44; abundant large fibroblasts&#44; and chronic inflammatory cells&#44; and covered by intact or ulcerated stratified&#44; nonkeratinizing&#44; squamous epithelium&#46; These tumors contain a laminar osteoid-like mineralized material&#44; cement-like concretions&#44; or a mixture of both&#46; Radiography is the imaging test of choice&#44; and reveals a radiolucent&#44; radiopaque&#44; or mixed-density mass that does not affect the underlying bone&#46; Superficial bone erosion&#44; central radiopaque foci&#44; widening of the periodontal ligament&#44; or dental displacement may also be observed&#46;<a class="elsevierStyleCrossRefs" href="#bib0005"><span class="elsevierStyleSup">1&#44;5</span></a></p><p id="par0090" class="elsevierStylePara elsevierViewall">The differential diagnosis is established based on clinical-pathological correlation and includes other localized reactive gingival hyperplasias such as pyogenic granuloma&#44; gingival fibroma&#44; and peripheral giant cell granuloma&#59; benign conditions such as fibrous dysplasia or osteomyelitis&#59; and bone tumors&#44; both benign &#40;osteoid osteoma&#44; osteoblastoma&#44; cementoblastoma&#41; and malignant &#40;osteosarcoma&#41;&#46;<a class="elsevierStyleCrossRefs" href="#bib0005"><span class="elsevierStyleSup">1&#44;4&#44;6</span></a> Juvenile ossifying fibroma&#44; a variant of PCOF with a worse prognosis&#44; was ruled out in our patient&#46;</p><p id="par0060" class="elsevierStylePara elsevierViewall">Treatment consists of excision of the lesion and deep curettage of the periosteum and periodontal ligament&#44; with recurrence in 8&#37; to 30&#37; of cases depending on the series&#44;<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a> probably due to inadequate curettage and the persistence of chronic irritants&#46; Malignant transformation has not been described&#46;<a class="elsevierStyleCrossRef" href="#bib0020"><span class="elsevierStyleSup">4</span></a></p><p id="par0095" class="elsevierStylePara elsevierViewall">Dermatologists should be familiar with this entity in order to ensure correct differential diagnosis and to avoid unnecessary tests and procedures&#46;</p></span><span id="sec0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0035">Conflicts of Interest</span><p id="par0100" class="elsevierStylePara elsevierViewall">The authors declare that they have no conflicts of interest&#46;</p></span></span>"
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Vol. 105. Núm. 10.
Páginas 947-948 (diciembre 2014)
Visitas
6591
Vol. 105. Núm. 10.
Páginas 947-948 (diciembre 2014)
Case for Diagnosis
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Polypoid Lesion of the Gum
Lesión polipoide en la encía
Visitas
6591
N. Puentea,
Autor para correspondencia
, Á. Castañob, A. Hernández-Núñeza
a Servicio de Dermatología, Hospital Universitario de Fuenlabrada, Madrid, Spain
b Servicio de Anatomía Patológica, Hospital Universitario de Fuenlabrada, Madrid, Spain
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Medical History

A 14-year-old boy with no relevant past medical history presented with a lesion on the upper gum that had developed 6 weeks previously. The patient reported that the lesion had grown progressively, resulting in increasing discomfort and slight bleeding caused by friction.

Physical Examination

Physical examination revealed a 5-mm polypoid lesion of normal mucosal color and firm rubbery consistency located between the medial and lateral incisors of the upper right gum (Fig. 1). No movement or alterations of the teeth were observed, nor were any other lesions detected in either the oral cavity or the cervical region. Curettage of the lesion was performed, followed by hemostasis with silver nitrate.

Figure 1
(0.12MB).
Histology

Histology showed fibrous tissue with prominent fusiform fibroblasts, among which lamellar bone trabeculae were dispersed (Figs. 2 and 3). Immunohistochemistry revealed that the cell population was positive for vimentin and had a mean Ki-67 value of 23%, but was negative for the markers CD31, CD34, von Willebrand factor, cytokeratin AE1/AE3, epithelial membrane antigen, smooth muscle actin, muscle-specific actin, desmin, CD68, and S-100 protein.

Figure 2.

Hematoxylin-eosin, original magnification ×10.

(0.31MB).
Figure 3.

Hematoxylin-eosin, original magnification ×20.

(0.31MB).

What Is Your Diagnosis?

Diagnosis

Peripheral cemento-ossifying fibroma (PCOF).

Clinical Course and Treatment

Two weeks after treatment the appearance of the gum had improved, with no recurrence or residual lesion.

Comment

PCOF is a fibro-osseous, osteogenic, reactive hyperplasia. Its likely origin is the multipotent cells of the periodontal ligament, given its near-exclusive localization in the gums, the inverse relationship between age and incidence, and the presence of oxytalan fibers in the calcified matrix in some PCOF cases. While the pathogenesis of PCOF is unknown, this condition has been associated with trauma, the presence of ectopic remnants of the periodontal ligament, and the influence of female sex hormones and chronic irritants, including dental calculus, plaque, ill-fitting dentures, malpositioned teeth, and irregular dental restorations.1 Chronic irritation of the periosteum and periodontium result in the formation of reactive granulation tissue, which ultimately calcifies and undergoes fibrosis.2

PCOF is rare, with a higher incidence in white women in their second or third decade of life, and accounts for 3.1% of biopsied oral tumors.1,2

It presents as a slow-growing, asymptomatic lesion in most cases, although large lesions resulting in facial asymmetry or the displacement of adjacent teeth have been described.1 Physical examination reveals a firm, erythematous, sessile or pedunculated tumor of normal mucosal color and of less than 2cm in diameter, located in the interdental papilla.1 In most cases these tumors develop in the upper maxilla.3

Diagnosis is based on clinical-radiologic-pathologic correlation.4 Histologically, PCOF is a nonencapsulated lesion composed of connective tissue, abundant large fibroblasts, and chronic inflammatory cells, and covered by intact or ulcerated stratified, nonkeratinizing, squamous epithelium. These tumors contain a laminar osteoid-like mineralized material, cement-like concretions, or a mixture of both. Radiography is the imaging test of choice, and reveals a radiolucent, radiopaque, or mixed-density mass that does not affect the underlying bone. Superficial bone erosion, central radiopaque foci, widening of the periodontal ligament, or dental displacement may also be observed.1,5

The differential diagnosis is established based on clinical-pathological correlation and includes other localized reactive gingival hyperplasias such as pyogenic granuloma, gingival fibroma, and peripheral giant cell granuloma; benign conditions such as fibrous dysplasia or osteomyelitis; and bone tumors, both benign (osteoid osteoma, osteoblastoma, cementoblastoma) and malignant (osteosarcoma).1,4,6 Juvenile ossifying fibroma, a variant of PCOF with a worse prognosis, was ruled out in our patient.

Treatment consists of excision of the lesion and deep curettage of the periosteum and periodontal ligament, with recurrence in 8% to 30% of cases depending on the series,2 probably due to inadequate curettage and the persistence of chronic irritants. Malignant transformation has not been described.4

Dermatologists should be familiar with this entity in order to ensure correct differential diagnosis and to avoid unnecessary tests and procedures.

Conflicts of Interest

The authors declare that they have no conflicts of interest.

References
[1]
S.P. Duarte Hernández, F. Hernández Pérez, L.A. Martínez Manzanarez.
Peripheral ossifying fibroma of the maxilla: A case study.
ADM, 67 (2010), pp. 133-136
[2]
E. Verma, A.B. Chakki, S.C. Nagaral, K.K. Ganji.
Peripheral cemento-ossifying fibroma: Case series literature review.
Case Rep Dent, 2013 (2013), pp. 930870
[3]
A. Buchner, A. Shnaiderman-Shapiro, M. Vered.
Relative frequency of localized reactive hyperplastic lesions of the gingiva: A retrospective study of 1675 cases from Israel.
J Oral Pathol Med, 39 (2010), pp. 631-638
[4]
M. Galdeano Arenas, J.I. Crespo Pinilla, R. Alvarez Otero, A. Espeso Ferrero, A. Verrier Hernández.
Cemento-ossifying fibroma of mandibular gingiva: Single case report.
Med Oral, 9 (2004), pp. 176-179
[5]
E. Charro Huerga, I. Vázquez Mahía, G. Gómez Oliveira, S. Sironvalle Soliva, J.L. López Cedrún.
Fibroma osificante periférico.
Rev Esp Cir Oral y Maxilofac, 29 (2007), pp. 117-121
[6]
A. Nuño-González, F.J. Vicente-Martín, F.J. Salamanca-Santamaría.
A rapidly growing gingival nodule.
Actas Dermosifiliogr, 102 (2011), pp. 465-466

Please cite this article as: Puente N, Castaño Á, Hernández-Núñez A. Lesión polipoide en la encía. Actas Dermosifiliogr. 2014;105:947–948.

Copyright © 2013. Elsevier España, S.L.U. and AEDV
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