Información del artículo
Abstract
Photodynamic therapy (PDT) is approved for the treatment of actinic keratoses, superficial and nodular basal cell carcinomas, and recently, Bowehs disease. In the last decade the advances experienced in the study of the photodynamic reaction have expanded the spectrum of application to other cutaneous diseases, neoplastic as well as inflammatory and infectious ones. The experience in psoriasis, acne, common warts and cutaneous T cell lymphoma starts to be broad and interesting, which permits to define its use in these entities. Photodynamic therapy is also been tested for a great variety of dermatoses with different photosensitizers and light sources with variable results. In this paper we review the treatment of Bowehs disease and other indications different from non melanoma skin cancer with PDT, providing our experience.
Key words:
photodynamic therapy
photosensitizers
non melanoma skin cancer
Resumen
Las indicaciones aprobadas de la terapia fotodinámica (TFD) son las queratosis actínicas, carcinomas basocelulares superficiales y nodulares y recientemente la enfermedad de Bowen. En la última década el estudio de la reacción fotodinámica ha experimentado un avance, ampliándose su espectro de actuación a otras enfermedades cutáneas tanto tumorales como inflamatorias e infecciosas. La experiencia en psoriasis, acné, verrugas vulgares y linfoma cutáneo de células T comienza a ser amplia e interesante, lo que permite definir su uso en estos procesos. Otra gran variedad de dermatosis se está ensayando, con diferentes fotosensibilizantes y fuentes de luz, con resultados variables. En este artículo revisamos el tratamiento con TFD de la enfermedad de Bowen y de otras indicaciones diferentes de cáncer cutáneo no melanoma, añadiendo nuestra experiencia.
Palabras clave:
terapia fotodinámica
fotosensibilizantes
cáncer cutáneo no melanoma
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References
[1.]
C.A. Morton, S.B. Brown, S. Collins.
Guidelines for topical photodynamic therapy: report of a workshop for the British Photodermatology Group.
Br J Dermatol, 146 (2002), pp. 552-557
[2.]
E.L. Taylor, D.B. Brown.
The adventages of aminolevulinic acid photodynamic therapy in dermatology.
J Dermatol Treat, 13 (2002), pp. S3-11
[3.]
A.K. Gupta, J. Ryder.
Photodynamic therapy and topical aminolevulinic acid. An overview.
Am J Clin Dermatol, 4 (2003), pp. 699-708
[4.]
M. Alexiades-Armenakas.
Laser-mediated photodynamic therapy.
Clin Dermatol, 24 (2006), pp. 16-25
[5.]
N. Uebelhoer, J. Dover.
Photodynamic therapy for cosmetic applications.
Dermatol Ther, 18 (2005), pp. 242-252
[6.]
M. Gold, M. Goldman.
5-Aminolevulinic acid photodynamic therapy: where we have been and where we are going.
Dermatol Surg, 30 (2004), pp. 1077-1084
[7.]
W.H. Boehncke, K. Koning, A. Ruck, R. Kaufmann, W. Sterry.
In vitro and in vivo effects of photodynamic therapy in cutaneous T lymphoma.
Acta Derm Venereol, 74 (1994), pp. 201-205
[8.]
W.H. Boehncke, A. Ruck, J. Naumann, W. Sterry, R. Kaufmann.
Comparison of sensitivity towards photodynamic therapy of cutaneous resident and infiltrating cells types in vitro.
Lasers Surg Med, 19 (1996), pp. 451-457
[9.]
A. Orenstein, J. Haik, J. Tamir, E. Winkler, H. Trau, Z. Malik, et al.
Photodynamic therapy of cutaneous lymphoma using 5-aminolevulinic acid topical aplication.
Dermatol Surg, 26 (2000), pp. 765-769
[10.]
K. Rittenhous-Diakun, H. Van Leengoed, J. Morgan, E. Hryhorenko, G. Paszkievicz, J.E. Whitaker, et al.
The role of transferrin receptor (CD71) in photodynamic therapy of activated and malignant lymphocytes using the heme precursor delta-aminolevulinic acid (ALA).
Photochem Photobiol, 61 (1995), pp. 523-528
[11.]
A.R. Oseroff, J. Whitaker, C. Conti, et al.
Effects of fluence and intensity in PDT cutaneous T-cell lymphoma with topical ALA: High intensity spares the epidermis.
J Invest Dermatol, 100 (1996), pp. 602
[12.]
I. Wang, B. Bauer, S. Anderson-Engels.
Photodynamic therapy utilizing delta aminolevulinic acid in non-melanoma skins malignancies of the eyelid and periocular skin.
Acta Oftalm Scan, 77 (1999), pp. 182-188
[13.]
T. Markham, K. Sheehan, P. Collins.
Topical 5-aminolvulinic acid photodynamic therapy for tumour-stage mycosis fungoides.
Br J Dermatol, 144 (2001), pp. 1262
[14.]
D.W. Edstrom, A. Portwit, A.M. Ros.
Photodynamic therapy with topical 5-aminolvulinic acid for mycosis fungoides: clinical and histological response.
Acta Derm Venereol, 81 (2001), pp. 184-188
[15.]
J.A. Leman, D.C. Dick, C.A. Morton.
Topical 5-ALA therapy for the treatment of cutaneous T-cell lymphoma.
Clin Exp Dermatol, 27 (2002), pp. 516-518
[16.]
E.A. Coors, P. von den Driesch.
Topical photodynamic therapy for patients with therapy-resistant lesions of cutaneous T-cell lymphoma.
J Am Acad Dermatol, 50 (2004), pp. 363-367
[17.]
C. Zane, M. Venturini, R. Sala, P. Calzavara-Pinton.
Photodynamic therapy with mehtylaminolevulinate as a value treatment option for unilesional cutaneous T-cell lymphoma.
Photodermatol Photoinmunol Photomed, 22 (2006), pp. 254-258
[18.]
C. Fritsch, G. Goerz, T. Ruzicka.
Photodynamic therapy in dermatology.
Arch Dermatol, 13 (1998), pp. 207-214
[19.]
I.M. Stender, N. Bech-Thomsen, T. Poulsen, H.C. Wulf.
Photodynamic therapy with topical delta aminolevulinic acid delays UV carcinogenesis in hairless mice.
Photochem Photobiol, 66 (1997), pp. 493-496
[20.]
S. Sharfaei, G. Viau, H. Lui, D. Bouffard, R. Bissonnette.
Systemic photodynamic therapy with aminolevulinic acid delays the appearance of ultraviolet-induced skin tumours in mice.
Br J Dermatol, 144 (2001), pp. 1207-1214
[21.]
Y. De Graaf, C. Kennedy, R. Wolterbeek, A. Collen, R. Willemze, B. Bavink.
Photodynamic therapy does not prevent cutaneous squamous-cell carcinoma in organ-transplant recipients: result of a randomized controlled trial.
J Invest Dermatol, 126 (2006), pp. 569-574
[22.]
D. Touma, M. Yaar, S. Whitehead, N. Konnikov, B.A. Gilchrest.
A trial of short incubation broad-area phtodynamic therapy for facial actinic keratosis and diffuse photodamage.
Arch Dermatol, 140 (2004), pp. 33-40
[23.]
D.J. Piacquadio, D.M. Chen, H.F. farber.
Photodynamic therapy with aminolevulinic acid topical solution and visible blue light in the treatment of multiple actinic keratoses of the face and scalp: investigator-blinded, phase 3, multicenter trials.
Arch Dermatol, 140 (2004), pp. 41-46
[24.]
M.R. Alexiades-Armenakas, R.G. Geronemus.
Laser-mediated photodynamic therapy of actinic keratoses.
Arch Dermatol, 139 (2003), pp. 1313-1320
[25.]
R. Bissonette, A. Bergeron, Y. Liu.
Large surface photodynamic therapy with aminolevulinc acid: treatment of actinic keratosis and beyond.
J Drugs Dermatol, 3 (2004), pp. S26-S31
[26.]
D.K. Avram, M.P. Goldman.
Effectiveness and safety of ALA-IPL in treating actinic keratoses and photodamage.
J Drugs Dermatol, 3 (2004), pp. S36-S39
[27.]
M. Goldman.
Terapia fotodinámica.
1.st ed., Editorial Elsevier, (2006),
[28.]
S.A. Khan, T.J. Dougherty, T.S. Mang.
An evaluation of photodynamic therapy in the management of cutaneous metastases of breast cancer.
Eur J Cancer, 29A (1993), pp. 1686-1690
[29.]
M. Lapes, J. Petera, M. Jirsa.
Photodynamic therapy of cutaneous metastases of breast cancer after local application of meso-tetra-(para-sulphophenyl)-porphin (TPPS4).
J Photochem Photobiol B, 36 (1996), pp. 205-207
[30.]
T. Henta, Y. Itoh, M. Kobayashi, Y. Ninomiya, A. Ishibashi.
Photodynamic therapy for inoperable vulval Paget's disease using delta-aminolaevulinic acid: successful management of a large skin lesion.
Br J Dermatol, 141 (1999), pp. 347-349
[31.]
P.M. Becker-Wegerich, C. Fritsch, K.W. Schulte, M. Megahed, W. Neuse, G. Goerz, et al.
Carbon dioxide laser treatment of extramammary Paget's disease guided by photodynamic diagnosis.
Br J Dermatol, 138 (1998), pp. 169-172
[32.]
Z.P. Berstein, D. Wilson, et al.
Pilot study PDT for the treatment of AIDS-associated Kaposi sarcoma.
Proc Soc Clin Oncol, 13 (1994), pp. 51
[33.]
K.M. Hebeda, M.T. Huizing, P.A. Brouwer, F.W. van der Meulen, H.J. Hulseboch, P. Reiss, et al.
Photodynamic therapy in AIDS-related cutaneous Kaposi sarcoma.
J Acquir Immune Defic Syndr Hum Retrovirol, 10 (1995), pp. 61-70
[34.]
P.G. Calzavara-Pinton.
Repetitive photodynamic therapy with topical 5-aminolaevulinic acid as an appropiate approach to the routine treatment of superficial nonmelanoma skin tumors.
J Photochem Photobiol B, 29 (1995), pp. 743-751
[35.]
T.L. Alster, E.L. Tanzi.
Photodynamic therapy with topical aminolevulinic acid and pulsed dye laser irradiation for sebaceous hyperplasia.
J Drugs Dermatol, 2 (2003), pp. 501-504
[36.]
M. Mori, P. Campoimi, L. Mavilia, R. Rossi, P. Cappugi, N. Pimpinelli.
Topical photodynamic therapy for primary cutaneous B-cell lymphoma: a pilot study.
J Am Acad Dermatol, 54 (2006), pp. 524-526
[37.]
L.R. Braathen, R.M. Szeimies, N. Basset-Seguin, R. Bissonnette, P. Foley, D. Pariser, et al.
International Society for Photodynamic Therapy in Dermatology. Guidelines on the use of photodynamic therapy for nonmelanoma skin cancer: an international consensus. International Society for Photodynamic Therapy in Dermatology, 2005.
J Am Acad Dermatol, (2007), pp. 125-143
[38.]
M.H. Cox, D.J. Eedy, C.A. Morton.
Guidelines for management of Bowen's disease.
Br J Dermatol, 141 (1999), pp. 633-641
[39.]
K. Svanberg, T. Andersson, D. Killander, I. Wang, U. Stenram, S. Andersson-Engels, et al.
Photodynamic therapy of non-melanoma malignant tumour using topical deltaaminolevulinic acid sensitization and laser irradiation.
Br J Dermatol, 130 (1994), pp. 743-751
[40.]
F. Cairnduff, M.R. Stringer, E.J. Hudson, D.V. Ash, S.B. Brown.
Superficial photodynamic therapy with 5-aminolaevulinic acid for superficial primary and secundary skin cancer.
Br J Cancer, 69 (1994), pp. 605-608
[41.]
C.A. Morton, C. Whitehurst, H. Moseley, J.H. Mc Coll, J.V. Moore, R.M. Mackie.
Comparison of photodynamic therapy with cryotherapy in the treatment of Bowen's disease.
Br J Dermatol, 135 (1996), pp. 766-771
[42.]
G.I. Stables, M.R. Stringer, D.J. Robinson, D.V. Ash.
Large patches of Bowen's disease treated by topical aminolaevulinic acid photodynamic therapy.
Br J Dermatol, 136 (1997), pp. 957-960
[43.]
G.I. Stables, M.R. Stringer, D.J. Robinson, D.V. Ash.
The treatment of Bowen's disease by topical aminolaevulinic acid photodynamic therapy.
Br J Dermatol, 139 (1998), pp. 74
[44.]
S. Varma, A. Anstey, H. Wilson, et al.
Photodynamic theray for the treatment of Bowen's disease, solar keratoses and superficial basal cell carcinoma: 12 months experience with a novel light source.
Br J Dermatol, 139 (1998), pp. 19
[45.]
C.A. Morton, C. Whitehurst, J.V. Moore, R.M. MacKie.
Comparison of red and green light in the treatment of Bowen's disease by photodynamic therapy.
Br J Dermatol, 143 (2000), pp. 767-772
[46.]
C.A. Morton, C. Whitehurst, J.H. McColl, J.V. Moore, R.M. MacKie.
Photodynamic therapy for large or multiple patches of Bowen disease and basal cell carcinoma.
Arch Dermatol, 137 (2001), pp. 319-324
[47.]
S. Varma, H. Wilson, H.A. Kurwa, B. Gambles, C. Charman, A.D. Pearse, et al.
Bowen's disease, solar keratoses and superficial basal cell carcinomas treated by photodynamic therapy using a large-field incoherent light source.
Br J Dermatol, 144 (2001), pp. 567-574
[48.]
T.W. Wong, H.M. Sheu, J.Y. Lee, R.J. Fletcher.
Photodynamic therapy for Bowen's disease (squamous cell carcinoma in situ) of the digit.
Dermatol Surg, 27 (2001), pp. 452-456
[49.]
A.T. Dijkstra, I.M. Majoie, J.W. van Dongen, H. van Weelden, W.A. van Vloten.
Photodynamic therapy with violet light and topical 6-aminolaevulinic acid in the treatment of actinic keratosis, Bowen's disease and basal cell carcinoma.
J Eur Acad Dermatol, 15 (2001), pp. 550-554
[50.]
A. Salim, J.A. Leman, J.H. McColl, R. Chapman, C.A. Morton.
Randomized comparison of photodynamic therapy with topical 5-fluorouracil in Bowen's disease.
Br J Dermatol, 148 (2003), pp. 539-543
[51.]
G. Dragieva, J. Hafner, R. Dummer, P. Schmid-Grendelmeier, M. Ross, B.M. Prinz, et al.
Topical photodynamic therapy in the treatment of actinic keratoses and Bowen's disease in transplant recipients.
Transplantation, 77 (2004), pp. 115-121
[52.]
J.E. Britton, V. Goulden, G. Stables, M. Stringer, R. Sheehan-Dare.
Investigation of the use of the pulsed dye laser in the treatment of Bowen's disease using 5-aminolaevulinic acid phototherapy.
Br J Dermatol, 153 (2005), pp. 780-784
[53.]
J. Baptista, C. Martínez, L. Leite, M. Cochito.
Our PDT experience in the treatment of non-melanoma skin cancer over the last 7 years.
J Eur Acad Dermatol Venereol, 20 (2006), pp. 693-697
[54.]
G.I. Stables, M.R. Stringer, D.J. Robinson, D.V. Ash.
Erythroplasia of Queyrat treated by topical aminolaevulinic acid photodynamic therapy.
Br J Dermatol, 140 (1998), pp. 514-517
[55.]
M.R. Alexiades-Armenakas, R.G. Geronemus.
Laser-mediated photodynamic therapy of actinic cheilitis.
J Drugs Dermatol, 3 (2004), pp. 548-551
[56.]
A. Hauschild, S. Lischner, B. Lange-Asschenfeldt, F. Egberts.
Treatment of actinic cheilitis using photodynamic therapy with methyl aminolevulinate: report of three cases.
Dermatol Surg, 31 (2005), pp. 1344-1347
[57.]
B. Pollock, D. Turner, M. Stringer.
Topical aminolaevulinic acid-photodynamic therapy for the treatment of acne vulgaris: a study of clinical efficacy and mechanism of action.
Br J Dermatol, 151 (2004), pp. 616-622
[58.]
S. Bhardwaj, T. Rohrer, K. Arndt.
Lasers and light therapy for acne vulgaris.
Semin Cutan Med Surg, 24 (2005), pp. 107-112
[59.]
A. Charakida, E. Seaton, M. Phototherapy in the treatment of acne vulgaris. Charakida.
What is its role?.
Am J Clin Dermatol, 5 (2004), pp. 211-216
[60.]
P. Papageorgiou, A. Katsambas, A. Chus.
Phototherapy with blue (415 nm) and red (660 nm) light in the treatment of acne vulgaris.
Br J Dermatol, 142 (2000), pp. 973-978
[61.]
B. Zeina, J. Greenman, W.M. Purcel, B. Das.
Killing of cutaneous microbial species by photodynamic therapy.
Br J Dermatol, 144 (2001), pp. 274-278
[62.]
W. Hongcharu.
Topical ALA-Photodynamic Therapy for the Treatment of Acne Vulgaris.
J Invest Dermatol, 115 (2000), pp. 183-192
[63.]
D.J. Robinson, P. Collins, M. Stringer, D.I. Vernon, G.I. Stables, S.B. Brown, et al.
Improved response of plaque psoriasis after multiple treatments with topical 5-aminolaevulinic acid photodynamic therapy.
Acta Derm Venereol, 79 (1999), pp. 451-455
[64.]
M.M. Kleinpenning, T.T. Smits, E. Ewalds, P. van Erp, P. van de Kerkhof, M. Gerritsen.
Heterogeneity of fluorescence in psoriasis alter application of 5-aminolevulinic acid: an immunohistochemical study.
Br J Dermatol, 155 (2006), pp. 539-545
[65.]
R. Bissonette, J.F. Tremblay, P. Jucenas, M. Boushira, H. Lui.
Systemic photodynamic therapy with aminolevulinic acid induces apoptosis in lesional T lymphocytes of psoriatic plaques.
J Invest Dermatol, 119 (2002), pp. 77-83
[66.]
W.H. Boenhncke, K. Koning, Haufmann, W. Scheffold, O. Prummer, W. Sterry.
Photodynamic therapy in psoriasis: suppression of cytokine production in vitro and recording of fluorescence modification during treatment in vivo.
Arch Dermatol Res, 286 (1994), pp. 300-303
[67.]
T. Smits, M.M. Kleinpenning, P. van Erp, P. van de Kerkhof, M. Gerritsen.
A placebo-controlled randomized study on the clinical effectiveness, immunohistochemical changes and protoporphyrin IX accumulation in fractionated 5-aminolaevulinic acid-photodynamic therapy in patients with psoriasis.
Br J Dermatol, 155 (2006), pp. 429-436
[68.]
J. Fransson, A.M. Ros.
Clinical and inmunohistochemical evaluation of psoriatic plaques treated with topical 5-aminolevulinic acid photodynamic therapy.
Photodermatol Photoimmunol Photomed, 21 (2005), pp. 326-332
[69.]
G. Weinstein, J. Mc Cullough, E. Jeffers.
Photodynamic therapy (PDT) on psoriasis with topical delta aminolevulinic acid (ALA): a pilot dose ranging study.
Photoderm Photoinm Photobiol, 10 (1994), pp. 92
[70.]
P. Collins, D.J. Robinson, M.R. Stringer, G.I. Stables, R.A. Sheehan-Dare.
The variable response of plaque psoriasis after a single treatment with topical 5-aminolevulinic acid photodynamic therapy.
Br J Dermatol, 137 (1997), pp. 743-749
[71.]
P.E. Beattie, R.S. Dawe, J. Ferguson, H. Ibbotson.
Lack of efficacy and tolerability of topical PDT for psoriasis in comparison with narrowband UVB phototherapy.
Clin Exp Dermatol, 5 (2004), pp. 560
[72.]
S. Radakovic-Fijan, U. Blecha-Thalhammer, V. Scheleyer, R.M. Szeimies, T. Zwingers, H. Honigsmann, et al.
Topical aminolaevulinic acid-based photodynamic therapy as a treatment option for psoriasis? Results of a randomized, observer-blinded study.
Br J Dermatol, 152 (2005), pp. 279-283
[73.]
V. Schleyer, S. Radakovic-Fijan, S. Karrer, T. Zwingers, M. Landthaler, R.M. Szeimies.
Disapponting results and low tolerability of photodynamic therapy with topical 5-aminolaevulinic acid in psoriasis. A randomized, double-blind phase I/II study.
J Eur Acad Dermatol, 20 (2006), pp. 823-828
[74.]
Y.J. Kim, H.Y. Kang, E.S. Lee, Y.C. Kim.
Topical 5-aminolaevulinic acid photodynamic therapy for intractable palmoplantar psoriasis.
J Dermatol, 34 (2007), pp. 37-40
[75.]
D.J. Robinson, H.S. de Bruijn, W.J. de Wolf, H.J. Sterenborg, W.M. Star.
Topical 5-aminolevulinic acid -photodynamic therapy of hairless mouse skin using two-fold illumination schemes: PpIX fluoresecence kinetics, photobleaching and biological effects.
Photochem Photobiol, 72 (2000), pp. 794-802
[76.]
E.R. de Hass, B. Kruijt, H.J. Sterenborg, H.A. Martino Neumann, D.J. Robinson.
Fractionated illumination significantly improves the response of superficial basal cell carcinoma to aminolevulinic acid photodynamic therapy.
J Invest Dermatol, 126 (2006), pp. 2679-2686
[77.]
P. Hillemanns, M. Untch, F. Prove.
Photodynamic therapy of vulvar lichen sclerosus with 5-aminolaevulinic acid.
Obstet Gynecol, 93 (1999), pp. 71-74
[78.]
S. Karrer, C. Abels, M. Landthaler, R.M. Szeimies.
Topical photodymanic therapy for localized scleroderma.
Acta Derm Venereol, 80 (2000), pp. 26-27
[79.]
F. Monfrecola, F. D’Anna, M. Delfino.
Topical hematoporphyrin therapy plus UVA for the treatment of alopecia areata.
Photodermatology, 4 (1987), pp. 305-306
[80.]
R. Bissonette, J. Shapiro, H. Zeng, D.I. McLean, H. Lui.
Topical photodynamic therapy with 5-aminolaevulinic acid does not induce hair regrowth in patients with extensive alopecia areata.
Br J Dermatol, 143 (2000), pp. 1032-1035
[81.]
B. Kirby, C. Whitehurst, J.V. Moore.
Treatment of lichen planus of the penis with PDT.
Br J Dermatol, 141 (1999), pp. 765-766
[82.]
F. Aghahosseine, F. Arbabi-Kalati, L. Ataie Fashtami, G. Esmaeeli Djavid, M. Fatech.
Methylene blue-mediated photodynamic therapy: A possible alternative treatment for oral lichen planus.
Lasers Surg Med, 38 (2006), pp. 33-38
[83.]
S. Karrer, C. Abel, M.B. Wimmershoff, M. Landthaler, R.M. Szeimies, et al.
Successful treatment of cutaneous sarcoidosis using topical photodynamic therapy.
Arch Dermatol, 138 (2002), pp. 581-584
[84.]
P. Babilas, S. Karrer, A. Sidoroff, M. Landthaler, R.M. Szeimies.
Photodynamic therapy in dermatology: an up to date.
Photodermatol Photoinmunol Photomed, 21 (2005), pp. 142-149
[85.]
R. Ruiz Rodríguez, J.G. Álvarez, P. Laen, A. Acevedo, S. Córdoba.
Photodynamic therapy with 5-aminolevulinic acid for recalcitrant familial benign pemphigus (Hailey-Hailey disease).
J Am Acad Dermatol, 47 (2002), pp. 740-742
[86.]
L.L. Chiu, C.H. Sun, A.T. Yeh, B. Torkian, A. Karamzadeh, B. Tromberg, et al.
Photodynamic therapy on keloid fibroblasts in tissue-engineered keratinocyte-fibroblast co-culture.
Lasers Surg Med, 37 (2005), pp. 231-244
[87.]
F.A. Nayeemuddin, M. Wong, J. Yell, L.E. Rhodes.
Topical photodynamic therapy in disseminated superficial actinic porokeratosis.
Clin Exp Dermatol, 27 (2002), pp. 703-706
[88.]
H. Takeda, T. Kaneko, K. Harada, Y. Matsusaki, H. Nakano, K. Hanada.
Successful treatment of lymphadenosis benigna cutis with topical photodynamic therapy with delta-aminolevulinic acid.
Dermatology, 211 (2005), pp. 264-266
[89.]
I.M. Stender, R. Na, H. Fogh, C. Gluud, H.C. Wulf.
Photodynamic therapy with 5-aminolevulinic acid or placebo for recalcitrant foot and hand warts: randomised double-blind trial.
Lancet, 355 (2000), pp. 963-966
[90.]
S.H. Ibbotson.
Topical 5-aminolaevulinic acid photodynamic therapy for the treatment of skin conditions other than non-melanoma skin cancer.
Br J Dermatol, 146 (2002), pp. 178-188
[91.]
E.S. Abdel-Hady, P. Martin-Hirsch, M. Duggan-Keen, P.L. Stern, J.V. Moore, G. Corbitt, et al.
Immunological and viral factors associated with the response of vulvar intraepithelial neoplasia to photodynamic therapy.
Cancer Res, 61 (2001), pp. 192-196
[92.]
I.M. Stender, J. Lock-Anderson, H.C. Wulf.
Recalcitrant hand and foot warts succesfully treated with photodynamic therapy with topical aminolaevulinic acid: a pilot study.
Clin Exp Dermatol, 24 (1999), pp. 154-159
[93.]
G. Fabbrocini, M. Costanzo, A. Riccardo, et al.
Photodynamic therapy with topical δ-aminolaevulinic acid for the treatment of plantar warts.
J Photochem Photobiol B, 61 (2001), pp. 30-34
[94.]
I.M. Stender, F.M. Borgbjerg, J. Villumsen, J. Lock-Andersen, H.C. Wulf.
Pain induced by photodynamic therapy of warts.
Photodermatol Photoinmunol Photomed, 22 (2006), pp. 304-309
[95.]
E.V. Ross, R. Romero, N. Kollias, C. Crum, R.R. Anderson.
Selectivity of protoporphyrin IX fluorescence for condylomata after topical application of 5-aminolaevulinic acid: implications for photodynamic treatment.
Br J Dermatol, 137 (1997), pp. 736-742
[96.]
R.G. Frank, J.D. Bos.
Photodynamic therapy for condylomata acuminatawith local aplication of 5-aminolevulinic acid.
Genitourn Med, 72 (1996), pp. 70-71
[97.]
M.K. Fehr, R. Hornung, A. Degen, V.A. Schwarz, D. Fink, U. Haller, et al.
Photodynamic therapy of vulvar and vaginal condyloma and intraepithelial neoplasia using topically applied 5-aminolevulinic acid.
Lasers Surg Med, 30 (2002), pp. 273-279
[98.]
I.M. Stefanaki, S. Georgiou, G.C. Themelis, E.M. Vazgiouraki, A.D. Tosca.
In vivo fluorescence kinetics and photodynamic therapy in condylomata acuminata.
Br J Dermatol, 149 (2003), pp. 972-976
[99.]
X.L. Wang, H.W. Wang, H.S. Wang, S.Z. Xu, K.H. Liao, P. Hillemanns.
Topical 5-aminolaevulinic acid-photodynamic therapy for the treatment of urethral condylomata acuminata.
Br J Dermatol, 151 (2004), pp. 880-885
[100.]
T. Herzinger, R. Wienecke, P. Weisenseel, C. Borelli, C. Berking, K. Degitz.
Photodynamic therapy of genital condylomata in men.
Clin Exp Dermatol, 31 (2006), pp. 51-53
[101.]
R.V. Lobraico, L.I. Grossweiner.
Clinical experiences with photodynamic therapy for recurrent malignancies of the lower female genital tract.
J Gynecol Surg, 9 (1993), pp. 29-34
[102.]
S. Karrer, R.M. Szeimies, C. Abels, U. Wlotzke, W. Stolz, M. Landthaler.
Epidermodysplasia verruciformis treated using topical 5-aminolevulinic acid photodynamic therapy.
Br J Dermatol, 140 (1999), pp. 935-938
[103.]
J.M. Bliss, C.E. Bigelow, T.H. Foster, C.G. Haidaris.
Susceptibility of Candida species to photodynamic effects of photofrin.
Antimicrob Agents Chemother, 48 (2004), pp. 2000-2006
[104.]
T.G. Smijs, R.N. van der Haas, J. Lugtenburg, Y. Liu.
Photodynamic treatment of the dermatophyte tricophyton rubrum and its microconidia with porphyrin photosensitizers.
Photochem Photobiol, 80 (2004), pp. 197-202
[105.]
P.G. Calzavara-Pinton, M. Venturini, R. Sala.
A comprehensive overview of photodynamic therapy in the treatment of superficial fungal infections of the skin.
J Photochem Photobiol B, 78 (2005), pp. 1-6
[106.]
H. Kamp, H.J. Tietz, M. Lutz, H. Piazena, P. Sowyrda, J. Lademann, et al.
Atifungal effec of 5-aminolevulinic acid PDT in Trichophyton rubrum.
Mycoses, 48 (2005), pp. 101-107
[107.]
P.G. Calzavara-Pinton, M. Venturini, R. Capezzera, R. Sala, C. Zane.
Photodynamic therapy of interdigital mycoses of the feet with topical application of 5-aminolevulinic acid.
Photodermatol Photoimmunol Photomed, 20 (2004), pp. 144-147
[108.]
K. Gardlo, Z. Horska, C.D. Enk, L. Rauch, M. Megahed, T. Ruzicka, et al.
Treatment of cutaneous leishmaniasis by photodynamic therapy.
J Am Acad Dermatol, 48 (2003), pp. 893-896
[109.]
A. Asilian, M. Davami.
Comparison between the efficacy of photodynamic therapy and topical paromomycin in the treatment of Old World cutaneous leishmaniasis: a placebo-controlled, randomized clinical trial.
Clin Exp Dermatol, 31 (2006), pp. 634-637
[110.]
M.S. Nestor, M.H. Gold, A.N. Kauvar.
The use of photodynamic therapy in dermatology: results of a consensus conference.
J Drugs Dermatol, 5 (2006), pp. 140-154
[111.]
P.K. Nootheti, M.P. Goldman.
Aminolevulinic acid-photodynamic therapy for photorejuvenation.
Dermatol Clin, 25 (2007), pp. 35-45
[112.]
T.S. Alster, S.S. Surin-Lord.
Photodynamic therapy: practical cosmetic applications.
J Drugs Dermatol, 5 (2006), pp. 764-768
[113.]
E.S. Marmur, K. Phelps, D.J. Goldberg.
Ultrastructural changes seen after ALA-IPL photorejuvenation: a pilot study.
J Cosmet Laser Ther, 7 (2005), pp. 21-24
[114.]
A.V. Evans, A. Robson, R.J. Barlow, H. Kurwa.
Treatment of port wine stains with photodynamic therapy, using pulsed dye laser as a light source, compared with pulsed dye laser alone: a pilot study.
Lasers Surg Med, 36 (2005), pp. 266-269
[115.]
M. Grossman, J. Wimberly, P. Dwyer, et al.
PDT for hirsutism.
Lasers Surg Med, Supl 7 (1995), pp. 44
[116.]
Y. Itoh, Y. Ninomiya, S. Tajima.
Photodynamic therapy of acne vulgaris with topical (-aminolevulinic acid and incoherent light in japanese patients.
Br J Dermatol, 144 (2001), pp. 575-579
[117.]
M.A. Arianee, V. Santos, V.G. Belo.
Effectiveness of photodynamic therapy with topical 5-aminolevulinic acid and intense pulsed light versus intense pulsed light alone in the treatment of acne vulgaris: comparative study.
Dermatol Surg, 31 (2005), pp. 910-915
[118.]
S. Wiegell, H. Wulf.
Photodynamic therapy of acne vulgaris using 5-aminolevulnic acid versus methyl aminolevulinate.
J Am Acad Dermatol, 54 (2006), pp. 647-651
[119.]
S.R. Wiegell, H.C. Wulf.
Photodynamic therapy of acne vulgaris using methyl amonilevulinate: a blinded, randomized, controlled trial.
Br J Dermatol, 154 (2006), pp. 969-976
[120.]
J. Rojanamatin, P. Choawawanich.
Treatment of inflammatory facial acne vulgaris with intense pulsed light and short contact of topical 5-aminolevulinic acid: a pilot study.
Dermatol Surg, 32 (2006), pp. 991-997
[121.]
C.K. Yeung, S.Y. Shek, P. Bjerring.
A comparative study of intense pulsed light alone and its combination with photodynamic therapy for treatment of facial acne in asian skin.
Lasers Surg Med, 39 (2007), pp. 1-6
[122.]
M.H. Gold, V.L. Bradshaw, M.M. Boring, T.M. Bridges, J.A. Biron.
Split-face comparison of photodynamic therapy with 5-aminolevulinic acid and intense pulsed light versus intense pulsed light alone for photodamage.
Dermatol Surg, 32 (2006), pp. 795-801
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