Información del artículo
Abstract
Recent decades have seen the inclusion of acne vulgaris as a potential new indication for photodynamic therapy. Photodynamic therapy and light sources can be considered to be additional tools for primary or adjunctive therapy in patients with recurrent acne or those in whom it is not possible to use other treatments. We investigated the use of pulsed dye laser plus methylaminolevulinate for photodynamic therapy and have performed a comparative study of the use of this laser alone and as an element in photodynamic therapy.
Keywords:
Acne
Photodynamic therapy
Pulsed dye laser
Resumen
La terapia fotodinámica (TFD) ha emergido en las últimas décadas en el estudio de potenciales nuevas indicaciones entre las que se encuentra el acné vulgar. La TFD y otras fuentes de luz pueden ser consideradas una herramienta adicional en el empleo, como tratamiento único o adyuvante, en pacientes con cuadros recidivantes o en los que no es posible la utilización de otras opciones terapéuticas. Planteamos la utilización de láser de colorante pulsado y metilaminolevulinato para la TFD. Realizamos un estudio comparativo entre el empleo aislado del láser de colorante pulsado frente a la terapia fotodinámica.
Palabras clave:
Acné
Terapia fotodinámica
Láser de colorante pulsado
El Texto completo está disponible en PDF
References
[1.]
M.H. Gold, V.L. Bradshaw, M.M. Boring.
The use of a novel intense pulsed light and heat source and ALA-PDT in the treatment of moderate to severe inflammatory acné vulgaris.
J Drugs Dermatol, 3 (2004), pp. S15-S19
[2.]
D.X. Divaris, J.C. Kennedy, R.H. Pottier.
Phototoxic damage to sebaceous glands and hair follicles of mice after systemic administration of 5-aminolevulinic acid correlates with localized protoporphyrin IX fluorescence.
Am J Pathol, 136 (1990), pp. 891-897
[3.]
W. Hongcharu, C.R. Taylor, Y. Chang.
Topical ALA-photodynamic therapy for the treatment of acné vulgaris.
J Invest Dermatol, 115 (2000), pp. 183-192
[4.]
A. Charakida, E.D. Seaton, M. Charakida.
Phototherapy in the treatment of acné vulgaris: what is its role?.
Am J Clin Dermatol, 5 (2004), pp. 211-216
[5.]
S.R. Wiegell, H.C. Wulf.
Photodynamic therapy of acné vulgaris using methyl aminolaevulinate: a blinded, randomized, controlled trial.
Br J Dermatol, 154 (2006), pp. 969-976
[6.]
C.M. Futsaether, B. Kjeldstad, A. Johnsson.
Intracellular pH changes induced in Propionibacterium acnes by UVA radiation and blue light.
J Photochem Photobiol B, 31 (1995), pp. 125-131
[7.]
S.S. Bhardwaj, T.E. Rohrer, K. Arndt.
Lasers and light therapy for acné vulgaris.
Semin Cutan Med Surg, 24 (2005), pp. 107-112
[8.]
A. Yung, G.I. Stables, C. Fernandez.
Microbiological effect of photodynamic therapy (PDT) in healthy volunteers: a comparative study using methyl aminolaevulinate and hexyl aminolaevulinate cream.
Clin Exp Dermatol, 32 (2007), pp. 716-721
[9.]
B. Pollock, D. Turner, M.R. Stringer.
Topical aminolaevulinic acidphotodynamic therapy for the treatment of acné vulgaris: a study of clinical efficacy and mechanism of action.
Br J Dermatol, 151 (2004), pp. 616-622
[10.]
T.S. Alster, S.S. Surin-Lord.
Photodynamic therapy: practical cosmetic applications.
J Drugs Dermatol, 5 (2006), pp. 764-768
[11.]
E.V. Ross.
Optical treatments for acné.
Dermatol Ther, 18 (2005), pp. 253-266
[12.]
M.S. Nestor, M.H. Gold, A.N. Kauvar.
The use of photodynamic therapy in dermatology: results of a consensus conference.
J Drugs Dermatol, 5 (2006), pp. 140-154
[13.]
M. Haedersdal, K. Togsverd-Bo, S.R. Wiegell.
Long-pulsed dye laser versus long-pulsed dye laser-assisted photodynamic therapy for acné vulgaris: A randomized controlled trial.
J Am Acad Dermatol, 58 (2008), pp. 387-394
[14.]
C. Horfelt, J. Funk, M. Frohm-Nilsson.
Topical methyl aminolaevulinate photodynamic therapy for treatment of facial acné vulgaris: results of a randomized, controlled study.
Br J Dermatol, 155 (2006), pp. 608-613
[15.]
M. Fernández-Guarino, I. García-Morales, A. Harto.
Photodynamic therapy: new indications.
Actas Dermosifiliogr, 98 (2007), pp. 377-395
[16.]
S.R. Wiegell, H.C. Wulf.
Photodynamic therapy of acné vulgaris using 5-aminolevulinic acid versus methyl aminolevulinate.
J Am Acad Dermatol, 54 (2006), pp. 647-651
[17.]
C. Fritsch, B. Homey, W. Stahl.
Preferential relative porphyrin enrichment in solar keratoses upon topical application of deltaaminolevulinic acid methylester.
Photochem Photobiol, 68 (1998), pp. 218-221
[18.]
K. Mariwalla, T.E. Rohrer.
Use of lasers and light-based therapies for treatment of acné vulgaris.
Lasers Surg Med, 37 (2005), pp. 333-342
[19.]
E.D. Seaton, A. Charakida, P.E. Mouser.
Pulsed-dye laser treatment for inflammatory acné vulgaris: randomised controlled trial.
Lancet, 362 (2003), pp. 1347-1352
[20.]
A. Ortíz, V.M. Van, G.P. Lask, P.S. Yamauchi.
A review of lasers and light sources in the treatment of acné vulgaris.
J Cosmet Laser Ther, 7 (2005), pp. 69-75
[21.]
A. Harto, I. García-Morales, P. Belmar, P. Jaen.
Pulsed dye laser treatment of acné. Study of clinical efficacy and mechanism of action.
Actas Dermosifiliogr, 98 (2007), pp. 415-419
[22.]
C.K. Yeung, S.Y. Shek, P. Bjerring.
A comparative study of intense pulsed light alone and its combination with photodynamic therapy for the treatment of facial acné in Asian skin.
Lasers Surg Med, 39 (2007), pp. 1-6
[23.]
Y. Itoh, Y. Ninomiya, S. Tajima, A. Ishibashi.
Photodynamic therapy for acné vulgaris with topical 5-aminolevulinic acid.
Arch Dermatol, 136 (2000), pp. 1093-1095
[24.]
N.S. Uebelhoer, J.S. Dover.
Photodynamic therapy for cosmetic applications.
Dermatol Ther, 18 (2005), pp. 242-252
[25.]
M. Alexiades-Armenakas.
Laser-mediated photodynamic therapy.
Clin Dermatol, 24 (2006), pp. 16-25
[26.]
K. Christiansen, P. Bjerring, A. Troilius.
5-ALA for photodynamic photorejuvenation--optimization of treatment regime based on normal-skin fluorescence measurements.
Lasers Surg Med, 39 (2007), pp. 302-310
[27.]
J. Rojanamatin, P. Choawawanich.
Treatment of inflammatory facial acné vulgaris with intense pulsed light and short contact of topical 5-aminolevulinic acid: a pilot study.
Dermatol Surg, 32 (2006), pp. 991-996
[28.]
A.F. Taub.
Photodynamic therapy for the treatment of acné: a pilot study.
J Drugs Dermatol, 3 (2004), pp. S10-S14
[29.]
M. Haedersdal, K. Togsverd-Bo, H.C. Wulf.
Evidence-based review of lasers, light sources and photodynamic therapy in the treatment of acné vulgaris.
J Eur Acad Dermatol Venereol, 22 (2008), pp. 267-278
[30.]
C. Fritsch, B. Verwohlt, K. Bolsen.
Influence of topical photodynamic therapy with 5-aminolevulinic acid on porphyrin metabolism.
Arch Dermatol Res, 288 (1996), pp. 517-521
[31.]
E. Rud, O. Gederaas, A. Hogset, K. Berg.
5-aminolevulinic acid, but not 5-aminolevulinic acid esters, is transported into adenocarcinoma cells by system BETA transporters.
Photochem Photobiol, 71 (2000), pp. 640-647
[32.]
S.R. Wiegell, J. Skiveren, P.A. Philipsen, H.C. Wulf.
Pain during photodynamic therapy is associated with protoporphyrin IX fluorescence and fluence rate.
Br J Dermatol, 158 (2008), pp. 727-733
[33.]
F.J. Moloney, P. Collins.
Randomized, double-blind, prospective study to compare topical 5-aminolaevulinic acid methylester with topical 5-aminolaevulinic acid photodynamic therapy for extensive scalp actinic keratosis.
Br J Dermatol, 157 (2007), pp. 87-91
[34.]
A. Kasche, S. Luderschmidt, J. Ring, R. Hein.
Photodynamic therapy induces less pain in patients treated with methyl aminolevulinate compared to aminolevulinic acid.
J Drugs Dermatol, 5 (2006), pp. 353-356
[35.]
D.I. Kuijpers, M.R. Thissen, C.A. Thissen, M.H. Neumann.
Similar effectiveness of methyl aminolevulinate and 5-aminolevulinate in topical photodynamic therapy for nodular basal cell carcinoma.
J Drugs Dermatol, 5 (2006), pp. 642-645
[36.]
M.B. Ericson, C. Sandberg, B. Stenquist.
Photodynamic therapy of actinic keratosis at varying fluence rates: assessment of photobleaching, pain and primary clinical outcome.
Br J Dermatol, 151 (2004), pp. 1204-1212
[37.]
C.C. Riddle, S.N. Terrell, M.B. Menser.
A review of photodynamic therapy (PDT) for the treatment of acné vulgaris.
J Drugs Dermatol, 8 (2009), pp. 1010-1019
[38.]
M. Fadel, M. Salah, N. Samy, S. Mona.
Liposomal methylene blue hydrogel for selective photodynamic therapy of acné vulgaris.
J Drugs Dermatol, 8 (2009), pp. 983-990
[39.]
J. De Leeuw, N. van der Beek, P. Bjerring.
Photodynamic therapy of acne’ vulgaris using 5-aminolevulinic acid 0.5% liposomalspray and intense pulsed light in combination with topicalkeratolytic agents.
J Eur Acad Dermatol Venereol, 24 (2010), pp. 460-469
[40.]
S.H. Oh, D.J. Ryu, E.C. Han, K.H. Lee, J.H. Lee.
A Comparative Study of Topical 5-Aminolevulinic Acid Incubation Times in Photodynamic Therapy with Intense Pulsed Light for the Treatment of Inflammatory Acne.
Dermatol Surg, 35 (2009), pp. 1918-1926
[41.]
G. Fabbrocini, S. Cacciapuoti, V. De Vita, N. Fardella, F. Pastore, G. Monfrecola.
The Effect of Aminolevulinic Acid Photodynamic Therapy on Microcomedones and Macrocomedones.
Dermatology, 219 (2009), pp. 322-328
[42.]
C. Hörfelt, B. Stenquist, C.B. Halldin, M.B. Ericson, A.M. Wennberg.
Single low-dose red light is as efficacious as methylaminolevulinate--photodynamic therapy for treatment of acné: clinical assessment and fluorescence monitoring.
Acta Derm Venereol, 89 (2009), pp. 372-378
[43.]
T. Passeron, A. Khemis, J.P. Ortonne.
Pulsed dye laser-mediated photodynamic therapy for acné inversa is not successful: A pilot study on four cases.
J Dermatolog Treat, 1 (2009), pp. 1-2
Copyright © 2010. Academia Española de Dermatología y Venereología and Elsevier España, S.L.
