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1</a>&#41;&#46; No hypopigmentation of the scalp hair was observed due to the use of hair dye&#44; or of terminal hair on other parts of the body at the time of examination&#46; Examination of the remaining skin surface revealed no associated hypopigmented macules&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia></span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">Additional Tests</span><p id="par0015" class="elsevierStylePara elsevierViewall">Light microscope examination of the hair showed an almost complete absence of melanin granules&#46; Depigmentation affected the entire length of some eyelashes and only the distal portion of others&#44; with a progressive increase in the number of granules to almost normal levels in the proximal portions &#40;<a class="elsevierStyleCrossRef" href="#fig0010">Fig&#46; 2</a>&#41;&#46;</p><elsevierMultimedia ident="fig0010"></elsevierMultimedia><p id="par0020" class="elsevierStylePara elsevierViewall">The blood count&#44; biochemistry&#44; and autoimmunity studies showed results typical of the underlying rheumatoid arthritis&#46;</p><p id="par0025" class="elsevierStylePara elsevierViewall">What Is Your Diagnosis&#63;</p></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">Diagnosis</span><p id="par0030" class="elsevierStylePara elsevierViewall">Chloroquine-induced depigmentation&#46;</p></span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">Clinical Course and Treatment</span><p id="par0035" class="elsevierStylePara elsevierViewall">Clinical suspicion of hypopigmentation due to the use of high doses of chloroquine prompted a change in treatment to leflunomide 10&#160;mg&#47;d with the prednisone maintained at the previous dosage&#46;</p></span><span id="sec0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">Comment</span><p id="par0040" class="elsevierStylePara elsevierViewall">Chloroquine induced hypopigmentation was first described in 1948<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a> but only 50 new cases have been published since&#46;<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a> In most of those cases the patients had received high doses of chloroquine &#40;between 300&#160;and 400&#160;mg&#47;d&#41; and presented hypopigmentation with a preference for the eyebrows&#44; eyelashes&#44; moustache&#44; and body hair&#46;<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a> Hypopigmentation was more common in patients with light hair than dark hair&#46;<a class="elsevierStyleCrossRef" href="#bib0020"><span class="elsevierStyleSup">4</span></a></p><p id="par0045" class="elsevierStylePara elsevierViewall">Most of the published cases show that depigmentation is reversible on interruption of treatment with chloroquine&#44; dose reduction&#44; or even substitution of chloroquine by hydroxychloroquine&#46;<a class="elsevierStyleCrossRefs" href="#bib0015"><span class="elsevierStyleSup">3&#44;5</span></a></p><p id="par0050" class="elsevierStylePara elsevierViewall">The mechanism of action of chloroquine-induced depigmentation is not fully understood&#46; Chloroquine-melanin interaction allows us to suggest that this drug may interfere with melanogenesis&#46;<a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">6</span></a> The condition shows a preference for tissues rich in melanin&#44; which is found in highest concentrations in the skin and eyes&#46; In chloroquine-induced retinopathy there is irreversible fixation of the drug to the pigmentary epithelium&#44; but the process is reversible over time in the skin as the chloroquine deposited in the melanocytes transfers to the keratinocytes and is later eliminated by desquamation&#46;<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a> As the drug builds up in pigmented epithelia&#44; the accumulation of melanin in the melanosomes in the prolongations of the hair bulb is partially or completely inhibited&#46; This indicates that chloroquine exerts a toxic effect on melanocytes that blocks melanin production&#46;<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a></p><p id="par0055" class="elsevierStylePara elsevierViewall">Several authors have shown that chloroquine has a tendency to accumulate in the skin and that the amount of the drug detected is directly proportional to the dose administered and the duration of treatment&#46; Depigmentation of fair or red hair is far more common than that of darker hair&#44; suggesting the possibility of a greater interaction between chloroquine and pheomelanin than between chloroquine and eumelanin&#46;<a class="elsevierStyleCrossRefs" href="#bib0020"><span class="elsevierStyleSup">4&#44;6</span></a></p><p id="par0060" class="elsevierStylePara elsevierViewall">In conclusion&#44; chloroquine-induced hypopigmentation is similar to vitiligo&#44; and although it is a rare collateral effect it represents one end of the spectrum of chloroquine-induced pigmentary disorders&#46;</p></span></span>"
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Información de la revista
Vol. 102. Núm. 6.
Páginas 463-464 (agosto 2011)
Visitas
9825
Vol. 102. Núm. 6.
Páginas 463-464 (agosto 2011)
Case for Diagnosis
Acceso a texto completo
Hypopigmentation of the Eyelashes
Hipopigmentación de las pestañas
Visitas
9825
M. Gómez Vázqueza,
Autor para correspondencia
mergova@terra.es

Corresponding author.
, R. Navarraa, M. Castellanosb
a Servicio de Dermatología, Hospital Municipal de Badalona, Barcelona, Spain
b Servicio de Reumatología, Hospital Municipal de Badalona, Barcelona, Spain
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Medical History

The patient was a 36-year-old woman diagnosed with rheumatoid arthritis in 2008 and on treatment with chloroquine 250 mg/d and oral prednisone 5 mg/d since April 2008. In October 2009 the daily dose of chloroquine was increased to 500mg due to poor control of the symptoms of the underlying disease. The patient came to the outpatient clinic for hypopigmentation of the eyelashes present since February 2010.

Physical Examination

The patient had chestnut hair and skin phototype II but presented white eyelashes on the upper and lower eyelids of both eyes (Fig. 1). No hypopigmentation of the scalp hair was observed due to the use of hair dye, or of terminal hair on other parts of the body at the time of examination. Examination of the remaining skin surface revealed no associated hypopigmented macules.

Figure 1
(0.08MB).
Additional Tests

Light microscope examination of the hair showed an almost complete absence of melanin granules. Depigmentation affected the entire length of some eyelashes and only the distal portion of others, with a progressive increase in the number of granules to almost normal levels in the proximal portions (Fig. 2).

Figure 2
(0.07MB).

The blood count, biochemistry, and autoimmunity studies showed results typical of the underlying rheumatoid arthritis.

What Is Your Diagnosis?

Diagnosis

Chloroquine-induced depigmentation.

Clinical Course and Treatment

Clinical suspicion of hypopigmentation due to the use of high doses of chloroquine prompted a change in treatment to leflunomide 10 mg/d with the prednisone maintained at the previous dosage.

Comment

Chloroquine induced hypopigmentation was first described in 19481 but only 50 new cases have been published since.2 In most of those cases the patients had received high doses of chloroquine (between 300 and 400 mg/d) and presented hypopigmentation with a preference for the eyebrows, eyelashes, moustache, and body hair.3 Hypopigmentation was more common in patients with light hair than dark hair.4

Most of the published cases show that depigmentation is reversible on interruption of treatment with chloroquine, dose reduction, or even substitution of chloroquine by hydroxychloroquine.3,5

The mechanism of action of chloroquine-induced depigmentation is not fully understood. Chloroquine-melanin interaction allows us to suggest that this drug may interfere with melanogenesis.6 The condition shows a preference for tissues rich in melanin, which is found in highest concentrations in the skin and eyes. In chloroquine-induced retinopathy there is irreversible fixation of the drug to the pigmentary epithelium, but the process is reversible over time in the skin as the chloroquine deposited in the melanocytes transfers to the keratinocytes and is later eliminated by desquamation.3 As the drug builds up in pigmented epithelia, the accumulation of melanin in the melanosomes in the prolongations of the hair bulb is partially or completely inhibited. This indicates that chloroquine exerts a toxic effect on melanocytes that blocks melanin production.3

Several authors have shown that chloroquine has a tendency to accumulate in the skin and that the amount of the drug detected is directly proportional to the dose administered and the duration of treatment. Depigmentation of fair or red hair is far more common than that of darker hair, suggesting the possibility of a greater interaction between chloroquine and pheomelanin than between chloroquine and eumelanin.4,6

In conclusion, chloroquine-induced hypopigmentation is similar to vitiligo, and although it is a rare collateral effect it represents one end of the spectrum of chloroquine-induced pigmentary disorders.

References
[1]
A.S. Alving, L. Eigherberger, B. Craige Jr., R. Jones Jr., C.M. Whorton, T.N. Pullman.
Studies on the chronic toxicity of chloroquine.
J Clin Invest, 27 (1948), pp. 60-65
[2]
P. Lecocq, E. Wyderkiewicz, P. Mikolajczak, G. Guerbeau.
Discoloration of hair under the effect of hydroxycloroquine.
Presse Med, 28 (1999), pp. 741
[3]
P.H. Ash, P. Caussade, C. Marquart- Elbaz, N. Boehm, E. Grosshans.
Chloroquine-induced achromotrichia. An ultrastructural study.
Ann Dermatol Venereol, 124 (1997), pp. 552-556
[4]
T.B. Di Giacomo, N.Y.S. Valente, M.M.S. Nico.
Chloroquine induce hair depigmentation.
Lupus, 18 (2009), pp. 264-266
[5]
T.S. Saunders, T.B. Fitzpatrick, M. Seiji, P. Brunet, E.E. Rosenbaum.
Decrease in human hair color and feather pigment of fowl following chloroquine disphosfate.
J Invest Dermatol, 33 (1965), pp. 87-90
[6]
U. Runne, F.R. Ochsendorf, K. Schmidt, H.W. Raudonat.
Sequential concentration of choroquine in human hair correlates with ingested doses and duration of therapy.
Acta Derm Venereol, 72 (1992), pp. 355-357

Please cite this article as: Gómez-Vázquez M, et al. Hipopigmentación de las pestañas. Actas Dermosifiliogr.2011;102:463-464.

Copyright © 2010. Elsevier España, S.L. and AEDV
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