Resident’s Forum
RF-Prurigo Nodularis: Associations With Neoplasms, Recommendations for Additional Testing, and Novel Treatments
FR-Prurigo nodular: asociación con neoplasias, pruebas complementarias y nuevos tratamientos
L. Serra-García, D. Morgado-Carrasco
Autor para correspondencia
Departamento de Dermatología, Hospital Clínic de Barcelona, Universitat de Barcelona, Barcelona, Spain
Leído
5151
Vecesse ha leído el artículo
1670
Total PDF
3481
Total HTML
Compartir estadísticas
array:25 [ "pii" => "S1578219021001578" "issn" => "15782190" "doi" => "10.1016/j.adengl.2021.04.003" "estado" => "S300" "fechaPublicacion" => "2021-07-01" "aid" => "2598" "copyright" => "AEDV" "copyrightAnyo" => "2021" "documento" => "article" "crossmark" => 1 "licencia" => "http://creativecommons.org/licenses/by-nc-nd/4.0/" "subdocumento" => "sco" "cita" => "Actas Dermosifiliogr. 2021;112:663-4" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "Traduccion" => array:1 [ "es" => array:20 [ "pii" => "S0001731021000934" "issn" => "00017310" "doi" => "10.1016/j.ad.2019.08.004" "estado" => "S300" "fechaPublicacion" => "2021-07-01" "aid" => "2598" "copyright" => "AEDV" "documento" => "article" "crossmark" => 1 "licencia" => "http://creativecommons.org/licenses/by-nc-nd/4.0/" "subdocumento" => "sco" "cita" => "Actas Dermosifiliogr. 2021;112:663-4" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "es" => array:10 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">FORO DE RESIDENTES</span>" "titulo" => "FR-Prurigo nodular: asociación con neoplasias, pruebas complementarias y nuevos tratamientos" "tienePdf" => "es" "tieneTextoCompleto" => "es" "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "663" "paginaFinal" => "664" ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "RF-Prurigo Nodularis: Associations With Neoplasms, Recommendations for Additional Testing, and Novel Treatments" ] ] "contieneTextoCompleto" => array:1 [ "es" => true ] "contienePdf" => array:1 [ "es" => true ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "L. Serra-García, D. Morgado-Carrasco" "autores" => array:2 [ 0 => array:2 [ "nombre" => "L." "apellidos" => "Serra-García" ] 1 => array:2 [ "nombre" => "D." "apellidos" => "Morgado-Carrasco" ] ] ] ] ] "idiomaDefecto" => "es" "Traduccion" => array:1 [ "en" => array:9 [ "pii" => "S1578219021001578" "doi" => "10.1016/j.adengl.2021.04.003" "estado" => "S300" "subdocumento" => "" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1578219021001578?idApp=UINPBA000044" ] ] "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0001731021000934?idApp=UINPBA000044" "url" => "/00017310/0000011200000007/v1_202107020537/S0001731021000934/v1_202107020537/es/main.assets" ] ] "itemSiguiente" => array:20 [ "pii" => "S1578219021001633" "issn" => "15782190" "doi" => "10.1016/j.adengl.2021.05.004" "estado" => "S300" "fechaPublicacion" => "2021-07-01" "aid" => "2582" "copyright" => "AEDV" "documento" => "article" "crossmark" => 1 "licencia" => "http://creativecommons.org/licenses/by-nc-nd/4.0/" "subdocumento" => "sco" "cita" => "Actas Dermosifiliogr. 2021;112:665-6" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "en" => array:10 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Resident's Forum</span>" "titulo" => "RF-Herpes Zoster Triggered by Ingenol Mebutate Gel: First European Case Report" "tienePdf" => "en" "tieneTextoCompleto" => "en" "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "665" "paginaFinal" => "666" ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "FR-Aparición de herpes zoster secundario a la aplicación de ingenol mebutato en gel: comunicación del primer caso europeo" ] ] "contieneTextoCompleto" => array:1 [ "en" => true ] "contienePdf" => array:1 [ "en" => true ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "M. Garayar Cantero, E. Manrique-Silva, E. Godoy-Gijón" "autores" => array:3 [ 0 => array:2 [ "nombre" => "M." "apellidos" => "Garayar Cantero" ] 1 => array:2 [ "nombre" => "E." "apellidos" => "Manrique-Silva" ] 2 => array:2 [ "nombre" => "E." "apellidos" => "Godoy-Gijón" ] ] ] ] ] "idiomaDefecto" => "en" "Traduccion" => array:1 [ "es" => array:9 [ "pii" => "S0001731021000016" "doi" => "10.1016/j.ad.2019.07.021" "estado" => "S300" "subdocumento" => "" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0001731021000016?idApp=UINPBA000044" ] ] "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1578219021001633?idApp=UINPBA000044" "url" => "/15782190/0000011200000007/v1_202107020822/S1578219021001633/v1_202107020822/en/main.assets" ] "itemAnterior" => array:19 [ "pii" => "S1578219021001608" "issn" => "15782190" "doi" => "10.1016/j.adengl.2021.05.001" "estado" => "S300" "fechaPublicacion" => "2021-07-01" "aid" => "2610" "copyright" => "AEDV" "documento" => "article" "crossmark" => 1 "licencia" => "http://creativecommons.org/licenses/by-nc-nd/4.0/" "subdocumento" => "sco" "cita" => "Actas Dermosifiliogr. 2021;112:661-2" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "en" => array:11 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Images in Dermatology</span>" "titulo" => "Neutrophilic Dermatosis on the Dorsal Hands" "tienePdf" => "en" "tieneTextoCompleto" => "en" "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "661" "paginaFinal" => "662" ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Dermatosis neutrofílica del dorso de las manos" ] ] "contieneTextoCompleto" => array:1 [ "en" => true ] "contienePdf" => array:1 [ "en" => true ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0005" "etiqueta" => "Figure 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 1452 "Ancho" => 2174 "Tamanyo" => 502788 ] ] "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at0005" "detalle" => "Figure " "rol" => "short" ] ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "L. Quintana Castanedo, C. Chiloeches Fernández, E. Sendagorta Cudós" "autores" => array:3 [ 0 => array:2 [ "nombre" => "L." "apellidos" => "Quintana Castanedo" ] 1 => array:2 [ "nombre" => "C." "apellidos" => "Chiloeches Fernández" ] 2 => array:2 [ "nombre" => "E." "apellidos" => "Sendagorta Cudós" ] ] ] ] ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1578219021001608?idApp=UINPBA000044" "url" => "/15782190/0000011200000007/v1_202107020822/S1578219021001608/v1_202107020822/en/main.assets" ] "en" => array:16 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Resident’s Forum</span>" "titulo" => "RF-Prurigo Nodularis: Associations With Neoplasms, Recommendations for Additional Testing, and Novel Treatments" "tieneTextoCompleto" => true "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "663" "paginaFinal" => "664" ] ] "autores" => array:1 [ 0 => array:4 [ "autoresLista" => "L. Serra-García, D. Morgado-Carrasco" "autores" => array:2 [ 0 => array:2 [ "nombre" => "L." "apellidos" => "Serra-García" ] 1 => array:4 [ "nombre" => "D." "apellidos" => "Morgado-Carrasco" "email" => array:1 [ 0 => "danielmorgado@yahoo.com.ar" ] "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "*" "identificador" => "cor0005" ] ] ] ] "afiliaciones" => array:1 [ 0 => array:2 [ "entidad" => "Departamento de Dermatología, Hospital Clínic de Barcelona, Universitat de Barcelona, Barcelona, Spain" "identificador" => "aff0005" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "⁎" "correspondencia" => "Corresponding author." ] ] ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "FR-Prurigo nodular: asociación con neoplasias, pruebas complementarias y nuevos tratamientos" ] ] "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">Prurigo nodularis (PN) is a chronic, difficult-to-treat pruriginous disease that can have a significant impact on a patient’s quality of life. It is a neurodermatitis in which the itch-scratch cycle perpetuates the nodular lesions. The cause is unknown, but the condition is associated with other skin diseases (mainly atopic dermatitis), systemic diseases (liver and renal failure and infections), neurologic and psychiatric disorders, and neoplasms.<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a></p><p id="par0010" class="elsevierStylePara elsevierViewall">Larson et al<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a> recently published the findings of the largest study to date on the association between PN and neoplasms. They included 695 diagnosed patients (51.6% women) between the ages of 40 and 69 years, comparing them to more than 2 million individuals with similar characteristics. The authors found that 17.8% of the patients with PN had some type of neoplasm and that malignancy was 4-fold more likely among those with PN than in the control individuals (odds ratio [OR], 4.54; 95% CI, 3.74–5.52). Skin tumors were the most common type of neoplasm (in 47%); the majority were basal cell carcinoma, followed in frequency by squamous cell carcinoma and melanoma. Solid organ tumors (in 32% of the patients) were mainly genital (in women), in the lung, or in the digestive tract. Blood neoplasms were found in 21% (mainly non-Hodgkin lymphoma, multiple myeloma, or primary cutaneous lymphoma). The patients with PN had significantly higher risk for skin cancer (OR, 10.94; 95% CI, 8.01–14.96), primary cutaneous lymphoma (OR, 24.82; 95% CI, 7.96–77.46), and female genital neoplasia (OR, 11.00; 95% CI, 4.90–24.68), among other malignant tumors. The pathophysiologic mechanism for the association between neoplasia and PN is unknown, but it may be related to a proinflammatory state.</p><p id="par0015" class="elsevierStylePara elsevierViewall">Given the strong association between PN and tumors in patients in the aforementioned study,<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a> a high index of suspicion is recommended. Also recommended is careful examination of skin and mucosal tissues and additional tests (<a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a>) following a multidisciplinary approach; screening for neoplasms according to sex and age should be included.<a class="elsevierStyleCrossRefs" href="#bib0005"><span class="elsevierStyleSup">1,2</span></a></p><elsevierMultimedia ident="tbl0005"></elsevierMultimedia><p id="par0020" class="elsevierStylePara elsevierViewall">There is limited evidence available on the treatment of PN given that fewer than 10 clinical trials have been published, and most are small.<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a> Good outcomes have been described after treatment with topical corticosteroids and calcineurin inhibitors, phototherapy, thalidomide (though its safety profile is poor), antiepileptics or anticonvulsives (pregabalin, gabapentin, or amitriptyline), ciclosporin, and methotrexate. A recent retrospective study of 39 patients with refractory PN showed an objectively measured response to methotrexate in 90% at 3 and 12 months, and complete resolution was observed at 12 months in 57%.<a class="elsevierStyleCrossRef" href="#bib0020"><span class="elsevierStyleSup">4</span></a> However, 12% of the patients had to stop treatment due to such adverse effects as transaminitis, pneumonitis, or gastrointestinal symptoms, among other events.<a class="elsevierStyleCrossRef" href="#bib0020"><span class="elsevierStyleSup">4</span></a> In our patients, we have also observed good responses to treatment with methotrexate and pregabalin.</p><p id="par0025" class="elsevierStylePara elsevierViewall">Emerging therapies include neurokinin 1 receptor antagonists such as aprepitant and serlopitant, the focus of an as-yet unpublished phase-3 trial; interleukin-31 inhibitors such as nemolizumab, currently being studied in a phase-2 trial; and opioid receptor agonists/antagonists such as nalbuphine. There is also the interleukin-4 inhibitor dupilumab.<a class="elsevierStyleCrossRef" href="#bib0025"><span class="elsevierStyleSup">5</span></a></p><p id="par0030" class="elsevierStylePara elsevierViewall">PN may be associated with neoplasms. A high index of clinical suspicion is necessary so that appropriate additional screening tests can be ordered. Treatment is complex, and clinical evidence is still limited.</p></span>" "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2019-07-30" "fechaAceptado" => "2019-08-07" "PalabrasClave" => array:1 [ "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Keywords" "identificador" => "xpalclavsec1395165" "palabras" => array:6 [ 0 => "Prurigo nodularis" 1 => "Malignant neoplasms" 2 => "Tumors" 3 => "Pruritus" 4 => "Methotrexate" 5 => "Dupilumab" ] ] ] ] "NotaPie" => array:1 [ 0 => array:2 [ "etiqueta" => "☆" "nota" => "<p class="elsevierStyleNotepara" id="npar0025">Please cite this article as: Serra-García L, Morgado-Carrasco D. FR-Prurigo nodular: asociación con neoplasias, pruebas complementarias y nuevos tratamientos. Actas Dermosifiliogr. 2021;112:663–664.</p>" ] ] "multimedia" => array:1 [ 0 => array:9 [ "identificador" => "tbl0005" "etiqueta" => "Table 1" "tipo" => "MULTIMEDIATABLA" "mostrarFloat" => true "mostrarDisplay" => false "fuente" => "Sources: Ständer et al<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a> and Larson et al.<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a>" "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at0005" "detalle" => "Table " "rol" => "short" ] ] "tabla" => array:3 [ "leyenda" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Abbreviation: PN, prurigo nodularis.</p>" "tablatextoimagen" => array:1 [ 0 => array:2 [ "tabla" => array:1 [ 0 => """ <table border="0" frame="\n \t\t\t\t\tvoid\n \t\t\t\t" class=""><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " rowspan="3" align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Associated neoplasms</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Skin cancer (basal cell carcinoma, squamous cell carcinoma, and melanoma) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Solid-organ malignancies (female genitalia, breast, lung, digestive system, head and neck, endocrine glands, urinary tract) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Hematologic neoplasms (non-Hodgkin lymphoma, multiple myeloma, primary cutaneous lymphomas, lymphocytic leukemia, myeloid leukemia, Hodgkin lymphoma) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Physical examination \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Look for signs of atopic dermatitis, bullous pemphigoid, skin cancer, and primary cutaneous lymphoma. \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " rowspan="6" align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Tests</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Complete blood count, erythrocyte sedimentation rate, and ferritin level \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Creatinine level and liver-function tests \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Blood sugar and thyroid function tests \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Serology for human immunodeficiency virus infection and hepatitis B and C virus infections<a class="elsevierStyleCrossRef" href="#tblfn0005"><span class="elsevierStyleSup">a</span></a> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Chest radiograph if lymphoma is suspected<a class="elsevierStyleCrossRef" href="#tblfn0005"><span class="elsevierStyleSup">a</span></a> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Skin biopsy<a class="elsevierStyleCrossRef" href="#tblfn0005"><span class="elsevierStyleSup">a</span></a> + negative direct immunofluorescence<a class="elsevierStyleCrossRef" href="#tblfn0010"><span class="elsevierStyleSup">b</span></a> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " rowspan="2" align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Multidisciplinary management</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Consult other specialists to screen for digestive, genital, or other neoplasms, as appropriate according to sex and age. \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Consider consulting a psychiatrist and/or a psychologist. \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " rowspan="5" align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Treatments</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">First line: Start with topical corticosteroid or calcineurin inhibitors and/or phototherapy.<a class="elsevierStyleCrossRef" href="#tblfn0015"><span class="elsevierStyleSup">c</span></a> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Second line: Add gabapentin or pregabalin. \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Third line: Evaluate the need for antidepressants (paroxetine or mirtazapine).<a class="elsevierStyleCrossRef" href="#tblfn0020"><span class="elsevierStyleSup">d</span></a> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Fourth line: Consider immunosuppressants (ciclosporin or methotrexate). \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Fifth line: Consider duplimab, aprepitant, serlopitant, or opioid receptor antagonists. \t\t\t\t\t\t\n \t\t\t\t</td></tr></tbody></table> """ ] "imagenFichero" => array:1 [ 0 => "xTab2648078.png" ] ] ] "notaPie" => array:4 [ 0 => array:3 [ "identificador" => "tblfn0005" "etiqueta" => "a" "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Biopsy to be considered, depending on clinical suspicion</p>" ] 1 => array:3 [ "identificador" => "tblfn0010" "etiqueta" => "b" "nota" => "<p class="elsevierStyleNotepara" id="npar0010">If autoimmune bullous disease is suspected</p>" ] 2 => array:3 [ "identificador" => "tblfn0015" "etiqueta" => "c" "nota" => "<p class="elsevierStyleNotepara" id="npar0015">Consider intralesional corticosteroids in patients with few lesions or isolated nodules that are refractory to treatment.</p>" ] 3 => array:3 [ "identificador" => "tblfn0020" "etiqueta" => "d" "nota" => "<p class="elsevierStyleNotepara" id="npar0020">Especially in patients with mood disorders or other psychological problems. Consider mirtazapine for patients with sleep disorders.</p>" ] ] ] "descripcion" => array:1 [ "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Management of PN: Associated Neoplasms, Physical Examination, Recommended Additional Tests, and Treatments</p>" ] ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:5 [ 0 => array:3 [ "identificador" => "bib0005" "etiqueta" => "1" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Diagnostic and treatment algorithm for chronic nodular prurigo" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "H.F. Ständer" 1 => "S. Elmariah" 2 => "C. Zeidler" 3 => "M. Spellman" 4 => "S. Ständer" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.jaad.2019.07.022" "Revista" => array:2 [ "tituloSerie" => "J Am Acad Dermatol" "fecha" => "2019" ] ] ] ] ] ] 1 => array:3 [ "identificador" => "bib0010" "etiqueta" => "2" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Association between prurigo nodularis and malignancy in middle-aged adults" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "V.A. Larson" 1 => "O. Tang" 2 => "S. Stander" 3 => "L.S. Miller" 4 => "S. Kang" 5 => "S.G. Kwatra" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.jaad.2019.03.083" "Revista" => array:2 [ "tituloSerie" => "J Am Acad Dermatol" "fecha" => "2019" ] ] ] ] ] ] 2 => array:3 [ "identificador" => "bib0015" "etiqueta" => "3" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "A systematic review of evidence-based treatments for prurigo nodularis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "A.A. Qureshi" 1 => "L.E. Abate" 2 => "G. Yosipovitch" 3 => "A.J. Friedman" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.jaad.2018.09.020" "Revista" => array:6 [ "tituloSerie" => "J Am Acad Dermatol" "fecha" => "2019" "volumen" => "80" "paginaInicial" => "756" "paginaFinal" => "764" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/30261199" "web" => "Medline" ] ] ] ] ] ] ] ] 3 => array:3 [ "identificador" => "bib0020" "etiqueta" => "4" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Treatment of prurigo with methotrexate: a multicentre retrospective study of 39 cases" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "T. Klejtman" 1 => "M. Beylot-Barry" 2 => "P. Joly" 3 => "M.A. Richard" 4 => "S. Debarbieux" 5 => "L. Misery" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "J Eur Acad Dermatol Venereol" "fecha" => "2018" "volumen" => "32" "paginaInicial" => "437" "paginaFinal" => "440" ] ] ] ] ] ] 4 => array:3 [ "identificador" => "bib0025" "etiqueta" => "5" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Dupilumab Treatment for Generalized Prurigo Nodularis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "K.M. Beck" 1 => "E.J. Yang" 2 => "S. Sekhon" 3 => "T. Bhutani" 4 => "W. Liao" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1001/jamadermatol.2018.3912" "Revista" => array:7 [ "tituloSerie" => "JAMA Dermatol" "fecha" => "2019" "volumen" => "155" "paginaInicial" => "118" "paginaFinal" => "120" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/30427994" "web" => "Medline" ] ] "itemHostRev" => array:3 [ "pii" => "S0140673605673941" "estado" => "S300" "issn" => "01406736" ] ] ] ] ] ] ] ] ] ] ] ] "idiomaDefecto" => "en" "url" => "/15782190/0000011200000007/v1_202107020822/S1578219021001578/v1_202107020822/en/main.assets" "Apartado" => array:4 [ "identificador" => "34945" "tipo" => "SECCION" "en" => array:2 [ "titulo" => "Resident's Forum" "idiomaDefecto" => true ] "idiomaDefecto" => "en" ] "PDF" => "https://static.elsevier.es/multimedia/15782190/0000011200000007/v1_202107020822/S1578219021001578/v1_202107020822/en/main.pdf?idApp=UINPBA000044&text.app=https://actasdermo.org/" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1578219021001578?idApp=UINPBA000044" ]
| año/Mes | Html | Total | |
|---|---|---|---|
| 2024 Noviembre | 21 | 9 | 30 |
| 2024 Octubre | 115 | 44 | 159 |
| 2024 Septiembre | 111 | 27 | 138 |
| 2024 Agosto | 116 | 71 | 187 |
| 2024 Julio | 102 | 37 | 139 |
| 2024 Junio | 121 | 72 | 193 |
| 2024 Mayo | 133 | 38 | 171 |
| 2024 Abril | 105 | 31 | 136 |
| 2024 Marzo | 107 | 38 | 145 |
| 2024 Febrero | 112 | 24 | 136 |
| 2024 Enero | 104 | 33 | 137 |
| 2023 Diciembre | 129 | 15 | 144 |
| 2023 Noviembre | 120 | 38 | 158 |
| 2023 Octubre | 86 | 19 | 105 |
| 2023 Septiembre | 84 | 30 | 114 |
| 2023 Agosto | 113 | 13 | 126 |
| 2023 Julio | 97 | 25 | 122 |
| 2023 Junio | 80 | 18 | 98 |
| 2023 Mayo | 112 | 20 | 132 |
| 2023 Abril | 63 | 23 | 86 |
| 2023 Marzo | 96 | 28 | 124 |
| 2023 Febrero | 73 | 23 | 96 |
| 2023 Enero | 84 | 40 | 124 |
| 2022 Diciembre | 64 | 36 | 100 |
| 2022 Noviembre | 43 | 33 | 76 |
| 2022 Octubre | 30 | 18 | 48 |
| 2022 Septiembre | 30 | 34 | 64 |
| 2022 Agosto | 31 | 45 | 76 |
| 2022 Julio | 25 | 43 | 68 |
| 2022 Junio | 23 | 36 | 59 |
| 2022 Mayo | 90 | 55 | 145 |
| 2022 Abril | 66 | 42 | 108 |
| 2022 Marzo | 87 | 65 | 152 |
| 2022 Febrero | 97 | 55 | 152 |
| 2022 Enero | 64 | 47 | 111 |
| 2021 Diciembre | 52 | 47 | 99 |
| 2021 Noviembre | 63 | 52 | 115 |
| 2021 Octubre | 62 | 72 | 134 |
| 2021 Septiembre | 49 | 50 | 99 |
| 2021 Agosto | 46 | 48 | 94 |
| 2021 Julio | 74 | 39 | 113 |
| 2021 Junio | 47 | 28 | 75 |
| 2021 Mayo | 47 | 44 | 91 |
| 2021 Abril | 107 | 65 | 172 |
Mostrar todo
