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A) Hiperplasia epidérmica, hiperqueratosis de la capa cornea, con presencia en dermis superficial de depósitos de pigmento acompañado de un infiltrado inflamatorio (hematoxilina & eosina ×4). B) Detalle de los depósitos de pigmento en el interior de los histiocitos y extracelulares, acompañados de infiltrado linfohistiocítico (hematoxilina & eosina ×40).</p>" ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "R. Conejero, C. Conejero, V. Alcalde, J. García-Latasa de Araníbar" "autores" => array:4 [ 0 => array:2 [ "nombre" => "R." "apellidos" => "Conejero" ] 1 => array:2 [ "nombre" => "C." "apellidos" => "Conejero" ] 2 => array:2 [ "nombre" => "V." "apellidos" => "Alcalde" ] 3 => array:2 [ "nombre" => "J." "apellidos" => "García-Latasa de Araníbar" ] ] ] ] ] "idiomaDefecto" => "es" "Traduccion" => array:1 [ "en" => array:9 [ "pii" => "S1578219020303164" "doi" => "10.1016/j.adengl.2020.10.021" "estado" => "S300" "subdocumento" => "" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1578219020303164?idApp=UINPBA000044" ] ] "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0001731020301861?idApp=UINPBA000044" "url" => "/00017310/0000011100000010/v1_202012050701/S0001731020301861/v1_202012050701/es/main.assets" ] ] "itemSiguiente" => array:20 [ "pii" => "S1578219020303206" "issn" => "15782190" "doi" => "10.1016/j.adengl.2020.10.024" "estado" => "S300" "fechaPublicacion" => "2020-12-01" "aid" => "2365" "copyright" => "AEDV" "documento" => "article" "crossmark" => 1 "licencia" => "http://creativecommons.org/licenses/by-nc-nd/4.0/" "subdocumento" => "crp" "cita" => "Actas Dermosifiliogr. 2020;111:897-9" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "en" => array:11 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Case and Research Letters</span>" "titulo" => "Treatment of Localized Cutaneous Leishmaniasis With Intralesional Meglumine Antimoniate and Photodynamic Therapy" "tienePdf" => "en" "tieneTextoCompleto" => "en" "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "897" "paginaFinal" => "899" ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Tratamiento de la leishmaniasis localizada mediante el antimoniato de meglumina intralesional y la terapia fotodinámica" ] ] "contieneTextoCompleto" => array:1 [ "en" => true ] "contienePdf" => array:1 [ "en" => true ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:8 [ "identificador" => "fig0005" "etiqueta" => "Figure 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 1000 "Ancho" => 750 "Tamanyo" => 98764 ] ] "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at0005" "detalle" => "Figure " "rol" => "short" ] ] "descripcion" => array:1 [ "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Cutaneous leishmaniasis. Solitary, indurated, crusty plaque on the forehead.</p>" ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "A. Costin, F. Bonito, J. Alves, H. Barreiros" "autores" => array:4 [ 0 => array:2 [ "nombre" => "A." "apellidos" => "Costin" ] 1 => array:2 [ "nombre" => "F." "apellidos" => "Bonito" ] 2 => array:2 [ "nombre" => "J." "apellidos" => "Alves" ] 3 => array:2 [ "nombre" => "H." "apellidos" => "Barreiros" ] ] ] ] ] "idiomaDefecto" => "en" "Traduccion" => array:1 [ "es" => array:9 [ "pii" => "S0001731020301629" "doi" => "10.1016/j.ad.2020.02.004" "estado" => "S300" "subdocumento" => "" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0001731020301629?idApp=UINPBA000044" ] ] "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1578219020303206?idApp=UINPBA000044" "url" => "/15782190/0000011100000010/v1_202012160744/S1578219020303206/v1_202012160744/en/main.assets" ] "itemAnterior" => array:19 [ "pii" => "S1578219020303280" "issn" => "15782190" "doi" => "10.1016/j.adengl.2020.10.028" "estado" => "S300" "fechaPublicacion" => "2020-12-01" "aid" => "2390" "documento" => "article" "crossmark" => 1 "licencia" => "http://creativecommons.org/licenses/by-nc-nd/4.0/" "subdocumento" => "crp" "cita" => "Actas Dermosifiliogr. 2020;111:892-5" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "en" => array:11 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Case and Research Letters</span>" "titulo" => "Whitish Dots Provide the Key to Diagnosing Condyloma Lata: A Report of 5 Cases" "tienePdf" => "en" "tieneTextoCompleto" => "en" "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "892" "paginaFinal" => "895" ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Puntos blanquecinos como clave diagnóstica de condilomas planos: reporte de 5 casos" ] ] "contieneTextoCompleto" => array:1 [ "en" => true ] "contienePdf" => array:1 [ "en" => true ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:8 [ "identificador" => "fig0005" "etiqueta" => "Figure 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 1041 "Ancho" => 1505 "Tamanyo" => 339246 ] ] "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at0060" "detalle" => "Figure " "rol" => "short" ] ] "descripcion" => array:1 [ "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Condylomata lata of the 4 patients who showed white spots in the central area of the lesion.</p>" ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "J. 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Conejero, C. Conejero, V. Alcalde, J. García-Latasa de Araníbar" "autores" => array:4 [ 0 => array:4 [ "nombre" => "R." "apellidos" => "Conejero" "email" => array:1 [ 0 => "raquel_conejero@hotmail.com" ] "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] 1 => array:2 [ "etiqueta" => "*" "identificador" => "cor0005" ] ] ] 1 => array:3 [ "nombre" => "C." "apellidos" => "Conejero" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] ] ] 2 => array:3 [ "nombre" => "V." "apellidos" => "Alcalde" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] ] ] 3 => array:3 [ "nombre" => "J." "apellidos" => "García-Latasa de Araníbar" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] ] ] ] "afiliaciones" => array:2 [ 0 => array:3 [ "entidad" => "Departamento de Dermatología, Hospital Royo Villanova, Zaragoza, Spain" "etiqueta" => "a" "identificador" => "aff0005" ] 1 => array:3 [ "entidad" => "Unidad de Dermatología, Centro Médico Millenium, Zaragoza, Spain" "etiqueta" => "b" "identificador" => "aff0010" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "⁎" "correspondencia" => "Corresponding author." ] ] ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Hiperplasia seudoepiteliomatosa: una reacción infrecuente de los tatuajes" ] ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:8 [ "identificador" => "fig0005" "etiqueta" => "Figure 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 605 "Ancho" => 805 "Tamanyo" => 119447 ] ] "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at0005" "detalle" => "Figure " "rol" => "short" ] ] "descripcion" => array:1 [ "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Tattoo on the left leg. Well-defined raised, thickened lesions are evident in the red-colored areas of skin, with no surrounding inflammatory reaction.</p>" ] ] ] "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">The growth in popularity of tattooing in recent decades has coincided with an increase in the number of articles describing adverse effects associated with tattooing.</p><p id="par0010" class="elsevierStylePara elsevierViewall">Complications associated with tattoos include cutaneous and systemic infectious processes, inflammatory reactions with varied histological patterns, the appearance of benign or malignant skin tumors in tattooed areas of skin, and various dermatoses in tattooed areas resulting from isomorphic phenomena.<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a></p><p id="par0015" class="elsevierStylePara elsevierViewall">A 39-year-old man consulted for an itchy rash in the red-ink areas of a tattoo completed 1 month earlier. Physical examination revealed well-defined, firm, raised, erythematous hyperkeratotic lesions coinciding with the areas of red ink (<a class="elsevierStyleCrossRef" href="#fig0005">Fig. 1</a>). Dermoscopy showed rounded or oval-shaped areas of variable size with an erythematous center and a pinkish periphery, separated from one other by yellowish hyperkeratotic scales (<a class="elsevierStyleCrossRef" href="#fig0010">Fig. 2</a>). Histology showed marked acanthosis and epidermal papillomatosis without atypical cells, hyperkeratosis and areas of parakeratosis, and intracellular and extracellular deposits of red pigment in the dermis accompanied by a predominantly lymphohistiocytic infiltrate (<a class="elsevierStyleCrossRef" href="#fig0015">Fig. 3</a>). Culture of a biopsy sample for fungi, bacteria, and mycobacteria was negative. The results of patch and prick tests were negative.</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><elsevierMultimedia ident="fig0010"></elsevierMultimedia><elsevierMultimedia ident="fig0015"></elsevierMultimedia><p id="par0020" class="elsevierStylePara elsevierViewall">The patient was diagnosed with pseudoepitheliomatous hyperplasia in skin areas tattooed with red ink.</p><p id="par0025" class="elsevierStylePara elsevierViewall">He began treatment with high-potency topical corticosteroids under occlusion, without improvement. Two subsequent subcutaneous corticosteroid infiltrations slightly improved the pruritus, but had no effect on the lesions. CO<span class="elsevierStyleInf">2</span> laser treatment was scheduled, but the patient failed to attend the appointment.</p><p id="par0030" class="elsevierStylePara elsevierViewall">Among complications of tattoos, pseudoepitheliomatous hyperplasia is a rare reaction. It consists of irregular hyperplasia of the epidermis with no atypia and little mitotic activity, accompanied by dermal inflammatory infiltrate with a reactive histological pattern in response to the damage caused.<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a></p><p id="par0035" class="elsevierStylePara elsevierViewall">Because only isolated cases have been described and a few short series of patients published,<a class="elsevierStyleCrossRefs" href="#bib0010"><span class="elsevierStyleSup">2–9</span></a> there are limited data on this entity and its response to treatment. Among the cases described, more than half occurred in areas tattooed with red ink. Most, including the present case, occurred within 3 months of receiving the tattoo. This temporal association can aid diagnosis.</p><p id="par0040" class="elsevierStylePara elsevierViewall">It is important to differentiate this lesion from true neoplasms such as squamous cell carcinoma, verrucous carcinoma, keratoacanthoma, and viral warts.<a class="elsevierStyleCrossRefs" href="#bib0045"><span class="elsevierStyleSup">9–11</span></a></p><p id="par0045" class="elsevierStylePara elsevierViewall">Treatments described include high-potency topical corticosteroids, which were effective in one case,<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a> and surgical excision (3 patients),<a class="elsevierStyleCrossRefs" href="#bib0040"><span class="elsevierStyleSup">8,9</span></a> which was not considered in the present case owing to the extent of the lesions. Successful treatment with CO<span class="elsevierStyleInf">2</span> laser has been recently reported.<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">7</span></a> In several cases, patients have been lost to follow-up.</p><p id="par0050" class="elsevierStylePara elsevierViewall">We present a case of pseudoepitheliomatous hyperplasia as a reaction to red tattoo ink. The literature on this characteristic reaction is scarce. This is the first such case described in Spain, and the first for which accompanying dermoscopic images are provided.</p><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0005">Conflicts of Interest</span><p id="par0055" class="elsevierStylePara elsevierViewall">The authors declare that they have no conflicts of interest.</p></span></span>" "textoCompletoSecciones" => array:1 [ "secciones" => array:2 [ 0 => array:2 [ "identificador" => "sec0005" "titulo" => "Conflicts of Interest" ] 1 => array:1 [ "titulo" => "References" ] ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "NotaPie" => array:1 [ 0 => array:2 [ "etiqueta" => "☆" "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Please cite this article as: Conejero R, Conejero C, Alcalde V, García-Latasa de Araníbar JA. Hiperplasia seudoepiteliomatosa: una reacción infrecuente de los tatuajes. Actas Dermosifiliogr. 2020;111:896–897.</p>" ] ] "multimedia" => array:3 [ 0 => array:8 [ "identificador" => "fig0005" "etiqueta" => "Figure 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 605 "Ancho" => 805 "Tamanyo" => 119447 ] ] "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at0005" "detalle" => "Figure " "rol" => "short" ] ] "descripcion" => array:1 [ "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Tattoo on the left leg. Well-defined raised, thickened lesions are evident in the red-colored areas of skin, with no surrounding inflammatory reaction.</p>" ] ] 1 => array:8 [ "identificador" => "fig0010" "etiqueta" => "Figure 2" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr2.jpeg" "Alto" => 605 "Ancho" => 805 "Tamanyo" => 115269 ] ] "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at0010" "detalle" => "Figure " "rol" => "short" ] ] "descripcion" => array:1 [ "en" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Dermoscopy image. Rounded and oval structures of variable size with an erythematous center and pinkish periphery, separated from one other by yellowish scales.</p>" ] ] 2 => array:8 [ "identificador" => "fig0015" "etiqueta" => "Figure 3" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr3.jpeg" "Alto" => 604 "Ancho" => 805 "Tamanyo" => 238701 ] ] "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at0015" "detalle" => "Figure " "rol" => "short" ] ] "descripcion" => array:1 [ "en" => "<p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Histopathological image. A, Epidermal hyperplasia, hyperkeratosis of the corneal layer, and pigment deposition in the superficial dermis accompanied by inflammatory infiltrate (hematoxylin-eosin, original magnification ×4). B, Detail of pigment deposits inside histiocytes and extracellular cells, accompanied by lymphohistiocytic infiltrate (hematoxylin-eosin, original magnification ×40).</p>" ] ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:11 [ 0 => array:3 [ "identificador" => "bib0005" "etiqueta" => "1" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Reacciones cutáneas adversas por tatuajes y <span class="elsevierStyleItalic">piercings</span>" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "J. Mataix" 1 => "J.F. 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año/Mes | Html | Total | |
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2024 Noviembre | 7 | 0 | 7 |
2024 Octubre | 113 | 56 | 169 |
2024 Septiembre | 127 | 41 | 168 |
2024 Agosto | 181 | 79 | 260 |
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2024 Junio | 149 | 45 | 194 |
2024 Mayo | 94 | 49 | 143 |
2024 Abril | 99 | 31 | 130 |
2024 Marzo | 113 | 33 | 146 |
2024 Febrero | 99 | 35 | 134 |
2024 Enero | 85 | 34 | 119 |
2023 Diciembre | 86 | 24 | 110 |
2023 Noviembre | 106 | 32 | 138 |
2023 Octubre | 95 | 45 | 140 |
2023 Septiembre | 79 | 36 | 115 |
2023 Agosto | 62 | 23 | 85 |
2023 Julio | 119 | 55 | 174 |
2023 Junio | 75 | 34 | 109 |
2023 Mayo | 83 | 42 | 125 |
2023 Abril | 65 | 35 | 100 |
2023 Marzo | 100 | 37 | 137 |
2023 Febrero | 74 | 41 | 115 |
2023 Enero | 84 | 52 | 136 |
2022 Diciembre | 87 | 43 | 130 |
2022 Noviembre | 61 | 36 | 97 |
2022 Octubre | 49 | 29 | 78 |
2022 Septiembre | 45 | 41 | 86 |
2022 Agosto | 49 | 54 | 103 |
2022 Julio | 64 | 49 | 113 |
2022 Junio | 40 | 33 | 73 |
2022 Mayo | 139 | 48 | 187 |
2022 Abril | 123 | 37 | 160 |
2022 Marzo | 122 | 57 | 179 |
2022 Febrero | 116 | 40 | 156 |
2022 Enero | 143 | 69 | 212 |
2021 Diciembre | 127 | 51 | 178 |
2021 Noviembre | 109 | 56 | 165 |
2021 Octubre | 116 | 68 | 184 |
2021 Septiembre | 120 | 52 | 172 |
2021 Agosto | 78 | 39 | 117 |
2021 Julio | 125 | 37 | 162 |
2021 Junio | 133 | 41 | 174 |
2021 Mayo | 125 | 67 | 192 |
2021 Abril | 199 | 90 | 289 |
2021 Marzo | 141 | 50 | 191 |
2021 Febrero | 80 | 50 | 130 |
2021 Enero | 69 | 40 | 109 |
2020 Diciembre | 42 | 21 | 63 |
2020 Noviembre | 25 | 10 | 35 |
2020 Octubre | 7 | 4 | 11 |