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The current name of lichenoid keratosis was proposed by Margolis en 1972&#46;<a class="elsevierStyleCrossRefs" href="#bib0005"><span class="elsevierStyleSup">1&#8211;4</span></a></p><p id="par0035" class="elsevierStylePara elsevierViewall">It is a disease of unknown etiology&#44; characterized by the presence of violaceous papules reminiscent of lichen planus&#44; distributed over the torso and extremities in a linear and&#47;or reticular symmetric&#44; bilateral pattern&#44; with a tendency to become generalized&#46;<a class="elsevierStyleCrossRef" href="#bib0025"><span class="elsevierStyleSup">4</span></a> Onset is usually in adulthood with no predominance of sex or race&#46; It follows a chronic course&#44; in which pruritus may vary from minimal or absent to very intense&#46;<a class="elsevierStyleCrossRefs" href="#bib0005"><span class="elsevierStyleSup">1&#44;4</span></a></p><p id="par0040" class="elsevierStylePara elsevierViewall">It has been reported to coexist with facial lesions that simulate seborrheic eczema or perioral dermatosis&#44; palmoplantar keratoderma&#44; and dystrophic ungual lesions&#46; In exceptional cases&#44; the presence of oral or genital sores has been reported&#44; and ocular lesions such as blepharitis&#44; keratoconjunctivitis&#44; or iridocyclitis&#46;<a class="elsevierStyleCrossRefs" href="#bib0005"><span class="elsevierStyleSup">1&#44;2</span></a></p><p id="par0045" class="elsevierStylePara elsevierViewall">Histopathology is nonspecific&#46; Focal parakeratotic hyperkeratosis is found with some follicular plugs&#46; Vacuolization of the basement layer is present&#46; A lymphocytic infiltrate in bands with a clearly defined lower limit can be seen in the upper dermis&#46;<a class="elsevierStyleCrossRefs" href="#bib0010"><span class="elsevierStyleSup">2&#8211;5</span></a> A purplish variety has been described&#44; characterized by hematic extravasation and occasional vasculitis&#46;<a class="elsevierStyleCrossRef" href="#bib0025"><span class="elsevierStyleSup">4</span></a> The differential diagnosis must include lichen planus&#44; drug-induced lichenoid eruptions&#44; pityriasis rubra pilaris&#44; pityriasis lichenoides&#44; mycosis fungoides&#44; and other processes&#46;<a class="elsevierStyleCrossRefs" href="#bib0010"><span class="elsevierStyleSup">2&#8211;5</span></a></p><p id="par0050" class="elsevierStylePara elsevierViewall">The definitive diagnosis is established by means of a clinical-disease correlation where the main clinical sign is the retiform appearance of the dermatosis and the characteristic erythematous-violaceous coloring of the papules&#44; in patients with no temporal association with medication&#46; The histologic findings that support the diagnosis are lymphocytic lichenoid dermatitis with varying degrees of acanthosis&#44; hyperkeratosis&#44; and foci of parakeratosis&#46; All these findings were present in the patient described&#46; Treatment with daily application of calcipotriol&#47;betamethasone cream was justified by the current understanding of the disease as a keratinization disorder&#44;<a class="elsevierStyleCrossRefs" href="#bib0025"><span class="elsevierStyleSup">5&#44;6</span></a> and the oral prednisone was justified by the intense pruritus&#44; 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Case for Diagnosis
Confluent, Retiform, Violaceous Hyperkeratotic Papules
Pápulas violáceas hiperqueratósicas confluentes retiformes
E. Garzón Aldása,b,
Autor para correspondencia
Eduderma@Hotmail.Com

Corresponding author.
a Clínica Dermatológica Garzón, Quito. Ecuador
b Departamento De Dermatología, Universidad Central Del Ecuador, Quito, Ecuador
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some of which were even purplish&#44; with a hyperkeratotic center&#44; which coalesced in a retiform pattern&#44; mainly on the flexor surface of the upper limbs &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>&#41;&#44; the axillary folds&#44; the root of the lower member and the groin&#44; and on the torso &#40;<a class="elsevierStyleCrossRef" href="#fig0010">Fig&#46; 2</a>&#41;&#46; The rest of the skin&#44; nails and mucosa were not involved&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><elsevierMultimedia ident="fig0010"></elsevierMultimedia></span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0015">Histopathology</span><p id="par0015" class="elsevierStylePara elsevierViewall">The histologic study of a skin biopsy revealed irregular epidermal acanthosis with hyperkeratosis and follicular keratotic plugs&#44; and a lymphocytic lichenoid inflammatory infiltrate in bands in the dermis&#44; with foci of vacuolar damage in the basement layer of the epidermis&#44; dilated blood vessels in the superficial plexus without vasculitis&#44; and some extravasated red blood cells &#40;<a class="elsevierStyleCrossRef" href="#fig0015">Fig&#46; 3</a>&#41;&#46;<span class="elsevierStyleDisplayedQuote" id="dsq0005"><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">&#91;&#91;&#63;&#93;&#93;What is your Diagnosis&#63;</p></span></p><elsevierMultimedia ident="fig0015"></elsevierMultimedia></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0020">Diagnosis</span><p id="par0020" class="elsevierStylePara elsevierViewall">Chronic lichenoid keratosis&#46;</p></span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0025">Clinical Course and Treatment</span><p id="par0025" class="elsevierStylePara elsevierViewall">Topical treatment was prescribed with a calcipotriol&#47;betamethasone cream and oral prednisone at a dose of 1&#8239;mg&#47;kg of weight&#59; this achieved a considerable reduction in the pruritus and resolution of the papular lesions&#44; leaving hyperpigmented postinflammatory patches&#44; after 4 weeks of treatment&#46;</p></span><span id="sec0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0030">Comments</span><p id="par0030" class="elsevierStylePara elsevierViewall">Chronic lichenoid keratosis or Nekam disease<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a> is a rarely reported and underdiagnosed entity&#46;<a class="elsevierStyleCrossRefs" href="#bib0005"><span class="elsevierStyleSup">1&#8211;4</span></a> It was first described by Kaposi in 1895 as a variant of lichen&#44; and dubbed <span class="elsevierStyleItalic">lichen ruber acuminatus verrucosus et reticularis</span>&#46;<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a> In 1938&#44; Nekam postulated that it was a variant of porokeratosis and therefore called it <span class="elsevierStyleItalic">porokeratosis striata lichenoides</span>&#46; 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palmoplantar keratoderma&#44; and dystrophic ungual lesions&#46; In exceptional cases&#44; the presence of oral or genital sores has been reported&#44; and ocular lesions such as blepharitis&#44; keratoconjunctivitis&#44; or iridocyclitis&#46;<a class="elsevierStyleCrossRefs" href="#bib0005"><span class="elsevierStyleSup">1&#44;2</span></a></p><p id="par0045" class="elsevierStylePara elsevierViewall">Histopathology is nonspecific&#46; Focal parakeratotic hyperkeratosis is found with some follicular plugs&#46; Vacuolization of the basement layer is present&#46; A lymphocytic infiltrate in bands with a clearly defined lower limit can be seen in the upper dermis&#46;<a class="elsevierStyleCrossRefs" href="#bib0010"><span class="elsevierStyleSup">2&#8211;5</span></a> A purplish variety has been described&#44; characterized by hematic extravasation and occasional vasculitis&#46;<a class="elsevierStyleCrossRef" href="#bib0025"><span class="elsevierStyleSup">4</span></a> The differential diagnosis must include lichen planus&#44; drug-induced lichenoid eruptions&#44; pityriasis rubra pilaris&#44; pityriasis lichenoides&#44; mycosis fungoides&#44; and other processes&#46;<a class="elsevierStyleCrossRefs" href="#bib0010"><span class="elsevierStyleSup">2&#8211;5</span></a></p><p id="par0050" class="elsevierStylePara elsevierViewall">The definitive diagnosis is established by means of a clinical-disease correlation where the main clinical sign is the retiform appearance of the dermatosis and the characteristic erythematous-violaceous coloring of the papules&#44; in patients with no temporal association with medication&#46; The histologic findings that support the diagnosis are lymphocytic lichenoid dermatitis with varying degrees of acanthosis&#44; hyperkeratosis&#44; and foci of parakeratosis&#46; All these findings were present in the patient described&#46; Treatment with daily application of calcipotriol&#47;betamethasone cream was justified by the current understanding of the disease as a keratinization disorder&#44;<a class="elsevierStyleCrossRefs" href="#bib0025"><span class="elsevierStyleSup">5&#44;6</span></a> and the oral prednisone was justified by the intense pruritus&#44; the considerable lymphocytic inflammatory infiltrate&#44; and the extent of the lesions on the body&#46; The patient&#8217;s diabetes was controlled with combination oral hypoglycemic agents&#44; with no complications&#46;</p></span><span id="sec0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0035">Conflicts of Interest</span><p id="par0055" class="elsevierStylePara elsevierViewall">The author declares that he has no conflicts of interest&#46;</p></span></span>"
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Información del artículo
ISSN: 15782190
Idioma original: Inglés
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