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Peña Merino, M. Mendieta-Eckert, I. Méndez Maestro, J. Gardeazabal García" "autores" => array:4 [ 0 => array:4 [ "nombre" => "L." "apellidos" => "Peña Merino" "email" => array:1 [ 0 => "lander_merino@hotmail.com" ] "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "*" "identificador" => "cor0005" ] ] ] 1 => array:2 [ "nombre" => "M." "apellidos" => "Mendieta-Eckert" ] 2 => array:2 [ "nombre" => "I." "apellidos" => "Méndez Maestro" ] 3 => array:2 [ "nombre" => "J." "apellidos" => "Gardeazabal García" ] ] "afiliaciones" => array:1 [ 0 => array:2 [ "entidad" => "Servicio de Dermatología, Hospital Universitario Cruces, Barakaldo, Vizcaya, Spain" "identificador" => "aff0005" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "⁎" "correspondencia" => "Corresponding author." ] ] ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Infección por <span class="elsevierStyleItalic">Mycobacterium marinum</span> en una paciente en tratamiento con adalimumab" ] ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:8 [ "identificador" => "fig0015" "etiqueta" => "Figure 3" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr3.jpeg" "Alto" => 497 "Ancho" => 1305 "Tamanyo" => 222251 ] ] "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at0015" "detalle" => "Figure " "rol" => "short" ] ] "descripcion" => array:1 [ "en" => "<p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">A, Hematoxylin-eosin staining shows well-defined granulomas, consisting of histiocytes and peripheral lymphocytes, located in the reticular dermis and hypodermis. B, Fite-Faraco staining reveals the presence of acid-alcohol resistant bacilli.</p>" ] ] ] "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">A 54-year-old woman who was being treated with subcutaneous adalimumab (40  mg/2 wk) for 1  year for rheumatoid arthritis was seen for a pruritic rash on her left hand. The rash had appeared 10 days earlier after she cut the third finger of the left hand while preparing fish in her workplace. The patient reported no previous contact with standing water (e.g. aquariums, ponds). Physical examination revealed multiple erythematous-violaceous papules of 3–4  mm on the dorsal aspect (<a class="elsevierStyleCrossRef" href="#fig0005">Fig. 1</a>) and palm of the left hand and on the wrist (<a class="elsevierStyleCrossRef" href="#fig0010">Fig. 2</a>). An erosion on the palmar aspect of the third finger of the same hand was identified by the patient as the initial injury (<a class="elsevierStyleCrossRef" href="#fig0010">Fig. 2</a>).</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><elsevierMultimedia ident="fig0010"></elsevierMultimedia><p id="par0010" class="elsevierStylePara elsevierViewall">Biopsy revealed an epidermis with acanthosis and isolated apoptotic keratinocytes, band-like inflammatory infiltrate, and basal vacuolar damage. Well-defined granulomas consisting of histiocytes and lymphocytes were observed in the reticular dermis and hypodermis (<a class="elsevierStyleCrossRef" href="#fig0015">Fig. 3</a>A). Giemsa, periodic acid-Schiff, and Grocott silver staining were negative for microorganisms. Fite-Faraco staining revealed the presence of acid-alcohol resistant bacilli (<a class="elsevierStyleCrossRef" href="#fig0015">Fig. 3</a>B).</p><elsevierMultimedia ident="fig0015"></elsevierMultimedia><p id="par0015" class="elsevierStylePara elsevierViewall">Culture of the biopsy material in Löwenstein-Jensen medium resulted in positive growth after 20 days, and <span class="elsevierStyleItalic">Mycobacterium marinum</span> was subsequently isolated by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS), enabling definitive diagnosis. The patient was diagnosed with a localized skin infection caused by <span class="elsevierStyleItalic">M marinum</span>, with a non-lymphocutaneous distribution. Antibiotic susceptibility testing showed that the microorganism was sensitive to kanamycin (high load), rifampin, ethambutol, ethionamide, cycloserine, and capreomycin, and was resistant to streptomycin, isoniazid, pyrazinamide, and paraaminosalicylic acid. The patient was initially prescribed minocycline (100  mg/12  h). After 2 months of treatment a marked improvement in the lesions was observed. However, because some active lesions persisted, antibiotic treatment was switched from minocycline to clarithromycin (500  mg/12  h). After another 2 months of treatment, the only remaining lesions were brownish macules, and antibiotic treatment was permanently discontinued. The patient experienced no subsequent recurrence after 6 months of follow-up.</p><p id="par0020" class="elsevierStylePara elsevierViewall">Mycobacterial species other than those of the <span class="elsevierStyleItalic">Mycobacterium tuberculosis</span> complex and <span class="elsevierStyleItalic">Mycobacterium leprae</span> are known as nontuberculous mycobacteria. The incidence of infections caused by these mycobacteria is increasing dramatically, mainly due to the prevalence of AIDS and the use of immunosuppressive therapies.<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a> The use of tumor necrosis factor inhibitors is associated with an increased risk of tuberculosis and of infection caused by nontuberculous mycobacteria.<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a></p><p id="par0025" class="elsevierStylePara elsevierViewall">The infection caused by <span class="elsevierStyleItalic">M marinum</span> is historically known as swimming pool or fish tank granuloma, owing to the wide distribution of this microorganism in aquatic environments, especially in stagnant water such as that found in fish ponds or swimming pools not treated with chlorine. The skin infection is acquired by contact with <span class="elsevierStyleItalic">M marinum</span>-contaminated water or with marine animals such as fish or crustaceans, and requires an entry site (usually minor skin trauma, which can be pre-existing or can coincide with exposure to the microorganism).</p><p id="par0030" class="elsevierStylePara elsevierViewall">The most common clinical presentation is nodular (60% of cases), consisting of a single lesion at the inoculation site, usually affecting the upper extremities. Multiple nodular lesions occur in 35% of cases, and are generally arranged linearly following a lymphatic path from the point of inoculation, producing a classical sporotrichoid or lymphocutaneous pattern. Disseminated infections have also been described in several immunocompromised patients.<a class="elsevierStyleCrossRefs" href="#bib0015"><span class="elsevierStyleSup">3,4</span></a></p><p id="par0035" class="elsevierStylePara elsevierViewall">Diagnosis is confirmed by culture of biopsy material. <span class="elsevierStyleItalic">M marinum</span> colonies are normally detected after 10 to 28 days of incubation, although cultures should be monitored for at least 6 weeks.<a class="elsevierStyleCrossRef" href="#bib0025"><span class="elsevierStyleSup">5</span></a> In one study, only a third of acid-fast-stained samples were positive.<a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">6</span></a></p><p id="par0040" class="elsevierStylePara elsevierViewall">A reasonable therapeutic strategy is to prescribe 2 active agents for up to 1 or 2 months after resolution of clinical signs (usually 3 or 4 months in total). For most patients, clarithromycin and ethambutol tend to provide an optimal balance of efficacy and tolerance.<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">7</span></a></p><p id="par0045" class="elsevierStylePara elsevierViewall">A search of the literature reveals 7 other cases of <span class="elsevierStyleItalic">M marinum</span> infection in patients receiving treatment with adalimumab for different diseases: rheumatoid arthritis (2), psoriasis (2), Crohn's disease (1), psoriatic arthritis (1), and ankylosing spondylitis (1).<a class="elsevierStyleCrossRef" href="#bib0040"><span class="elsevierStyleSup">8</span></a></p><p id="par0050" class="elsevierStylePara elsevierViewall">In conclusion, we present a case of <span class="elsevierStyleItalic">M marinum</span> infection with an atypical clinical presentation. This case underscores the risk of infection by nontuberculous mycobacteria in patients being treated with TNF inhibitors, and the importance of suspecting these infections, especially in individuals with a compatible exposure history.</p><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0005">Conflicts of Interest</span><p id="par0055" class="elsevierStylePara elsevierViewall">The authors declare that they have no conflicts of interest.</p></span></span>" "textoCompletoSecciones" => array:1 [ "secciones" => array:2 [ 0 => array:2 [ "identificador" => "sec0005" "titulo" => "Conflicts of Interest" ] 1 => array:1 [ "titulo" => "References" ] ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "NotaPie" => array:1 [ 0 => array:2 [ "etiqueta" => "☆" "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Please cite this article as: Peña Merino L, Mendieta-Eckert M, Méndez Maestro I, Gardeazabal García J. Infección por <span class="elsevierStyleItalic">Mycobacterium marinum</span> en una paciente en tratamiento con adalimumab. Actas Dermosifiliogr. 2020;111:525–526.</p>" ] ] "multimedia" => array:3 [ 0 => array:8 [ "identificador" => "fig0005" "etiqueta" => "Figure 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 421 "Ancho" => 755 "Tamanyo" => 63439 ] ] "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at0005" "detalle" => "Figure " "rol" => "short" ] ] "descripcion" => array:1 [ "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Multiple erythematous-violaceous papules of 3–4  mm on the back of the left hand.</p>" ] ] 1 => array:8 [ "identificador" => "fig0010" "etiqueta" => "Figure 2" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr2.jpeg" "Alto" => 520 "Ancho" => 755 "Tamanyo" => 59590 ] ] "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at0010" "detalle" => "Figure " "rol" => "short" ] ] "descripcion" => array:1 [ "en" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Similar lesions on the palm and wrist of the left hand, and an erosion on the palmar aspect of the third finger of the same hand.</p>" ] ] 2 => array:8 [ "identificador" => "fig0015" "etiqueta" => "Figure 3" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr3.jpeg" "Alto" => 497 "Ancho" => 1305 "Tamanyo" => 222251 ] ] "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at0015" "detalle" => "Figure " "rol" => "short" ] ] "descripcion" => array:1 [ "en" => "<p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">A, Hematoxylin-eosin staining shows well-defined granulomas, consisting of histiocytes and peripheral lymphocytes, located in the reticular dermis and hypodermis. B, Fite-Faraco staining reveals the presence of acid-alcohol resistant bacilli.</p>" ] ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:8 [ 0 => array:3 [ "identificador" => "bib0005" "etiqueta" => "1" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Nontuberculous mycobacterial infections of the skin: a retrospective study of 25 cases" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "R. Dodiuk-Gad" 1 => "P. Dyachenko" 2 => "M. Ziv" 3 => "A. Shani-Adir" 4 => "Y. Oren" 5 => "S. Mendelovici" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.jaad.2007.01.042" "Revista" => array:6 [ "tituloSerie" => "J Am Acad Dermatol." 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año/Mes | Html | Total | |
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2024 Noviembre | 4 | 5 | 9 |
2024 Octubre | 83 | 39 | 122 |
2024 Septiembre | 84 | 39 | 123 |
2024 Agosto | 93 | 64 | 157 |
2024 Julio | 103 | 55 | 158 |
2024 Junio | 94 | 59 | 153 |
2024 Mayo | 93 | 51 | 144 |
2024 Abril | 97 | 47 | 144 |
2024 Marzo | 80 | 34 | 114 |
2024 Febrero | 80 | 37 | 117 |
2024 Enero | 86 | 56 | 142 |
2023 Diciembre | 101 | 25 | 126 |
2023 Noviembre | 197 | 35 | 232 |
2023 Octubre | 192 | 25 | 217 |
2023 Septiembre | 159 | 39 | 198 |
2023 Agosto | 117 | 20 | 137 |
2023 Julio | 124 | 47 | 171 |
2023 Junio | 88 | 30 | 118 |
2023 Mayo | 148 | 40 | 188 |
2023 Abril | 183 | 34 | 217 |
2023 Marzo | 170 | 29 | 199 |
2023 Febrero | 147 | 25 | 172 |
2023 Enero | 139 | 31 | 170 |
2022 Diciembre | 120 | 38 | 158 |
2022 Noviembre | 75 | 36 | 111 |
2022 Octubre | 71 | 26 | 97 |
2022 Septiembre | 118 | 61 | 179 |
2022 Agosto | 146 | 58 | 204 |
2022 Julio | 96 | 58 | 154 |
2022 Junio | 50 | 49 | 99 |
2022 Mayo | 106 | 44 | 150 |
2022 Abril | 114 | 30 | 144 |
2022 Marzo | 93 | 48 | 141 |
2022 Febrero | 119 | 29 | 148 |
2022 Enero | 177 | 32 | 209 |
2021 Diciembre | 116 | 31 | 147 |
2021 Noviembre | 104 | 41 | 145 |
2021 Octubre | 136 | 58 | 194 |
2021 Septiembre | 117 | 34 | 151 |
2021 Agosto | 117 | 32 | 149 |
2021 Julio | 111 | 12 | 123 |
2021 Junio | 374 | 26 | 400 |
2021 Mayo | 90 | 36 | 126 |
2021 Abril | 347 | 79 | 426 |
2021 Marzo | 130 | 31 | 161 |
2021 Febrero | 72 | 27 | 99 |
2021 Enero | 55 | 15 | 70 |
2020 Diciembre | 49 | 14 | 63 |
2020 Noviembre | 46 | 21 | 67 |
2020 Octubre | 30 | 16 | 46 |
2020 Septiembre | 42 | 27 | 69 |
2020 Agosto | 60 | 29 | 89 |
2020 Julio | 22 | 22 | 44 |