Case and Research Letters
Chondroid Syringoma Mimicking Basal Cell Carcinoma
Siringoma condroide simulando un carcinoma basocelular
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"apellidos" => "Corral-Magaña" ] ] ] ] ] "idiomaDefecto" => "en" "Traduccion" => array:1 [ "es" => array:9 [ "pii" => "S0001731019301887" "doi" => "10.1016/j.ad.2018.09.015" "estado" => "S300" "subdocumento" => "" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0001731019301887?idApp=UINPBA000044" ] ] "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S157821902030072X?idApp=UINPBA000044" "url" => "/15782190/0000011100000004/v1_202006060751/S157821902030072X/v1_202006060751/en/main.assets" ] "en" => array:15 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Case and Research Letters</span>" "titulo" => "Chondroid Syringoma Mimicking Basal Cell Carcinoma" "tieneTextoCompleto" => true "saludo" => "To the Editor:" "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "341" "paginaFinal" => "343" ] ] "autores" => array:1 [ 0 => array:4 [ "autoresLista" => "L. Linares González, P. Aguayo Carreras, B. Rueda Villafranca, F.J. Navarro-Triviño" "autores" => array:4 [ 0 => array:4 [ "nombre" => "L." "apellidos" => "Linares González" "email" => array:1 [ 0 => "laura.linares.gz@gmail.com" ] "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">*</span>" "identificador" => "cor0005" ] ] ] 1 => array:3 [ "nombre" => "P." "apellidos" => "Aguayo Carreras" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] ] ] 2 => array:3 [ "nombre" => "B." "apellidos" => "Rueda Villafranca" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] ] ] 3 => array:3 [ "nombre" => "F.J." "apellidos" => "Navarro-Triviño" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] ] ] ] "afiliaciones" => array:2 [ 0 => array:3 [ "entidad" => "Unidad de Dermatología Médico-Quirúrgica y Venereología, Hospital Universitario San Cecilio, Granada, Spain" "etiqueta" => "a" "identificador" => "aff0005" ] 1 => array:3 [ "entidad" => "Unidad de Gestión Clínica de Anatomía Patológica, Hospital Universitario San Cecilio, Granada, Spain" "etiqueta" => "b" "identificador" => "aff0010" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "⁎" "correspondencia" => "Corresponding author." ] ] ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Siringoma condroide simulando un carcinoma basocelular" ] ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0005" "etiqueta" => "Figure 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 716 "Ancho" => 1305 "Tamanyo" => 114457 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">A, Red nodule with a smooth surface located in the upper third of the right nasogenian sulcus. B, Dermoscopy. Reddish-white bed with irregular telangiectatic vessels and cotton-white areas.</p>" ] ] ] "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">Chondroid syringoma, also known as a mixed skin tumor, is an infrequent neoplasm that is derived from the sweat glands and forms part of the large group of cutaneous adnexal neoplasms. Originally described by Billroth in 1859, it was not until 1961 that Hirsch and Heldwig first used the term to describe this entity, which is characterized by the presence of an epithelial component within a fibrochondroid stroma.<a class="elsevierStyleCrossRef" href="#bib0055"><span class="elsevierStyleSup">1</span></a> This tumor accounts for less than 0.1% of all diagnosed skin tumors.<a class="elsevierStyleCrossRef" href="#bib0060"><span class="elsevierStyleSup">2</span></a> Given its low incidence, together with its silent and nonspecific clinical presentation, clinicians often require histological data in order to establish diagnosis. The differential diagnosis should include other adnexal tumors. However, to date there have been no published descriptions of a clinical presentation mimicking basal cell carcinoma, as observed in the case reported here.</p><p id="par0010" class="elsevierStylePara elsevierViewall">A 48-year-old man with no medical history of interest consulted for an asymptomatic, slow-growing nodular lesion (1<span class="elsevierStyleHsp" style=""></span>cm in diameter) with a smooth, pearly surface, located in the upper third of the right nasogenian sulcus (<a class="elsevierStyleCrossRef" href="#fig0005">Fig. 1</a>A). Dermoscopy (<a class="elsevierStyleCrossRef" href="#fig0005">Fig. 1</a>B) revealed irregular telangiectatic vessels associated with cotton-white structures on an erythematous-white bed. The initial clinical suspicion was nodular basal cell carcinoma. Histology, performed after surgical removal of the tumor, was compatible with chondroid syringoma (<a class="elsevierStyleCrossRef" href="#fig0010">Fig. 2</a>).</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><elsevierMultimedia ident="fig0010"></elsevierMultimedia><p id="par0015" class="elsevierStylePara elsevierViewall">Chondroid syringoma is a benign tumor of adnexal origin that is more frequent in young men, and is typically located on the head and neck area, in particular on the nose, cheek, and upper lip, although involvement of other regions including the trunk, genital area, and extremities has also been described.<a class="elsevierStyleCrossRef" href="#bib0065"><span class="elsevierStyleSup">3</span></a> This tumor is usually solitary and rarely exceeds 2<span class="elsevierStyleHsp" style=""></span>cm in diameter. Malignant transformation is very rare but should be suspected in cases of chondroid syringoma exceeding 3<span class="elsevierStyleHsp" style=""></span>cm and located on the trunk and extremities in young women.<a class="elsevierStyleCrossRefs" href="#bib0070"><span class="elsevierStyleSup">4,5</span></a> Up to 50% of malignant chondroid syringomas metastasize to the lymph nodes, lungs, or bone.<a class="elsevierStyleCrossRefs" href="#bib0060"><span class="elsevierStyleSup">2,6</span></a></p><p id="par0020" class="elsevierStylePara elsevierViewall">Chondroid syringoma presents as a well-defined, slow-growing, firm, mobile painless nodule.<a class="elsevierStyleCrossRef" href="#bib0085"><span class="elsevierStyleSup">7</span></a> There is no specific, defined dermoscopic pattern that can provide diagnostically useful information.<a class="elsevierStyleCrossRef" href="#bib0090"><span class="elsevierStyleSup">8</span></a></p><p id="par0025" class="elsevierStylePara elsevierViewall">The nonspecific clinical and dermoscopic presentation of this neoplasm poses a real diagnostic challenge for dermatologists. The differential diagnosis should include cylindroma, hidradenoma, eccrine poroma, spiradenoma, intradermal nevus, papular mucinosis, and epidermal cyst.<a class="elsevierStyleCrossRef" href="#bib0085"><span class="elsevierStyleSup">7</span></a> In our case, the initial clinical suspicion was basal cell carcinoma owing to the atypical presentation of the tumor.</p><p id="par0030" class="elsevierStylePara elsevierViewall">Histology shows a well-defined tumor located in the dermis and/or subcutaneous tissue with epithelial and stromal components. The epithelial component includes glandular-like structures, nests, or cell strands that form ducts and tubules. The stromal component is characterized by a prominent mucinous stroma that eventually becomes chondroid and may contain hyalinized areas and myoepithelial cells.<a class="elsevierStyleCrossRef" href="#bib0095"><span class="elsevierStyleSup">9</span></a> Histological characteristics that are considered signs of malignant transformation include asymmetry, cytological atypia, infiltrative margins, satellite tumor nodules, necrosis, and compromise of deep structures.<a class="elsevierStyleCrossRefs" href="#bib0060"><span class="elsevierStyleSup">2,10</span></a></p><p id="par0035" class="elsevierStylePara elsevierViewall">Complete surgical removal is the treatment of choice, although other therapeutic alternatives such as electrocoagulation, dermabrasion, and vaporization with argon laser or CO<span class="elsevierStyleInf">2</span> laser have also been described.<a class="elsevierStyleCrossRef" href="#bib0060"><span class="elsevierStyleSup">2</span></a> In cases involving malignant transformation, removal with surgical margins of at least 1<span class="elsevierStyleHsp" style=""></span>cm is recommended, and adjuvant radiotherapy may also be considered.<a class="elsevierStyleCrossRef" href="#bib0075"><span class="elsevierStyleSup">5</span></a></p></span>" "pdfFichero" => "main.pdf" "tienePdf" => true "NotaPie" => array:1 [ 0 => array:2 [ "etiqueta" => "☆" "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Please cite this article as: Linares González L, Aguayo Carreras P, Rueda Villafranca B, Navarro-Triviño FJ. Siringoma condroide simulando un carcinoma basocelular. Actas Dermosifiliogr. 2020;111:341–343.</p>" ] ] "multimedia" => array:2 [ 0 => array:7 [ "identificador" => "fig0005" "etiqueta" => "Figure 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 716 "Ancho" => 1305 "Tamanyo" => 114457 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">A, Red nodule with a smooth surface located in the upper third of the right nasogenian sulcus. B, Dermoscopy. Reddish-white bed with irregular telangiectatic vessels and cotton-white areas.</p>" ] ] 1 => array:7 [ "identificador" => "fig0010" "etiqueta" => "Figure 2" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr2.jpeg" "Alto" => 991 "Ancho" => 1753 "Tamanyo" => 305349 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">A, Panoramic image showing a dermal tumor with well-defined borders and mild peripheral retraction (hematoxylin-eosin [HE], original magnification ×10). B, Higher magnification image showing cuboidal cells with eosinophilic cytoplasm and without cytological atypia, arranged in strands forming tubular structures (HE, original magnification ×20). C, ocally, the stroma has a chondroid and myxoid appearance (HE, original magnification ×40).</p>" ] ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0015" "bibliografiaReferencia" => array:10 [ 0 => array:3 [ "identificador" => "bib0055" "etiqueta" => "1" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Chondroid syringoma: mixed tumor of skin, salivary gland type" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "P. Hirsch" 1 => "E.B. 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| año/Mes | Html | Total | |
|---|---|---|---|
| 2024 Noviembre | 9 | 8 | 17 |
| 2024 Octubre | 120 | 45 | 165 |
| 2024 Septiembre | 95 | 24 | 119 |
| 2024 Agosto | 161 | 64 | 225 |
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| 2024 Junio | 93 | 51 | 144 |
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| 2024 Febrero | 80 | 30 | 110 |
| 2024 Enero | 75 | 39 | 114 |
| 2023 Diciembre | 67 | 17 | 84 |
| 2023 Noviembre | 92 | 51 | 143 |
| 2023 Octubre | 111 | 39 | 150 |
| 2023 Septiembre | 84 | 32 | 116 |
| 2023 Agosto | 66 | 27 | 93 |
| 2023 Julio | 100 | 41 | 141 |
| 2023 Junio | 69 | 24 | 93 |
| 2023 Mayo | 98 | 26 | 124 |
| 2023 Abril | 63 | 19 | 82 |
| 2023 Marzo | 100 | 23 | 123 |
| 2023 Febrero | 65 | 29 | 94 |
| 2023 Enero | 67 | 44 | 111 |
| 2022 Diciembre | 91 | 37 | 128 |
| 2022 Noviembre | 58 | 28 | 86 |
| 2022 Octubre | 41 | 33 | 74 |
| 2022 Septiembre | 46 | 41 | 87 |
| 2022 Agosto | 44 | 40 | 84 |
| 2022 Julio | 41 | 49 | 90 |
| 2022 Junio | 38 | 26 | 64 |
| 2022 Mayo | 69 | 39 | 108 |
| 2022 Abril | 77 | 45 | 122 |
| 2022 Marzo | 75 | 57 | 132 |
| 2022 Febrero | 48 | 34 | 82 |
| 2022 Enero | 93 | 39 | 132 |
| 2021 Diciembre | 69 | 40 | 109 |
| 2021 Noviembre | 70 | 47 | 117 |
| 2021 Octubre | 84 | 70 | 154 |
| 2021 Septiembre | 56 | 43 | 99 |
| 2021 Agosto | 65 | 35 | 100 |
| 2021 Julio | 48 | 17 | 65 |
| 2021 Junio | 51 | 29 | 80 |
| 2021 Mayo | 56 | 54 | 110 |
| 2021 Abril | 108 | 81 | 189 |
| 2021 Marzo | 54 | 32 | 86 |
| 2021 Febrero | 40 | 19 | 59 |
| 2021 Enero | 42 | 20 | 62 |
| 2020 Diciembre | 42 | 18 | 60 |
| 2020 Noviembre | 36 | 19 | 55 |
| 2020 Octubre | 36 | 27 | 63 |
| 2020 Septiembre | 42 | 18 | 60 |
| 2020 Agosto | 50 | 22 | 72 |
| 2020 Julio | 50 | 12 | 62 |
| 2020 Junio | 70 | 32 | 102 |
| 2020 Mayo | 40 | 24 | 64 |
| 2020 Abril | 6 | 2 | 8 |
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