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array:24 [ "pii" => "S1578219020300366" "issn" => "15782190" "doi" => "10.1016/j.adengl.2020.03.009" "estado" => "S300" "fechaPublicacion" => "2020-04-01" "aid" => "2280" "copyrightAnyo" => "2020" "documento" => "simple-article" "crossmark" => 1 "licencia" => "http://creativecommons.org/licenses/by-nc-nd/4.0/" "subdocumento" => "crp" "cita" => "Actas Dermosifiliogr. 2020;111:255-6" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "Traduccion" => array:1 [ "es" => array:19 [ "pii" => "S0001731019303825" "issn" => "00017310" "doi" => "10.1016/j.ad.2018.09.022" "estado" => "S300" "fechaPublicacion" => "2020-04-01" "aid" => "2280" "documento" => "simple-article" "crossmark" => 1 "licencia" => "http://creativecommons.org/licenses/by-nc-nd/4.0/" "subdocumento" => "crp" "cita" => "Actas Dermosifiliogr. 2020;111:255-6" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:2 [ "total" => 17 "formatos" => array:2 [ "HTML" => 15 "PDF" => 2 ] ] "es" => array:11 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">CASOS PARA EL DIAGNÓSTICO</span>" "titulo" => "Placas blancas en cavidad oral" "tienePdf" => "es" "tieneTextoCompleto" => "es" "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "255" "paginaFinal" => "256" ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "White Plaques in the Oral Cavity" ] ] "contieneTextoCompleto" => array:1 [ "es" => true ] "contienePdf" => array:1 [ "es" => true ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:6 [ "identificador" => "fig0005" "etiqueta" => "Figura 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 451 "Ancho" => 950 "Tamanyo" => 56912 ] ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "E. Rojas Mora, R. Kheadaoui, A. Hernández-Núñez" "autores" => array:3 [ 0 => array:2 [ "nombre" => "E." "apellidos" => "Rojas Mora" ] 1 => array:2 [ "nombre" => "R." "apellidos" => "Kheadaoui" ] 2 => array:2 [ "nombre" => "A." "apellidos" => "Hernández-Núñez" ] ] ] ] ] "idiomaDefecto" => "es" "Traduccion" => array:1 [ "en" => array:9 [ "pii" => "S1578219020300366" "doi" => "10.1016/j.adengl.2020.03.009" "estado" => "S300" "subdocumento" => "" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1578219020300366?idApp=UINPBA000044" ] ] "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0001731019303825?idApp=UINPBA000044" "url" => "/00017310/0000011100000003/v3_202009190646/S0001731019303825/v3_202009190646/es/main.assets" ] ] "itemSiguiente" => array:20 [ "pii" => "S1578219020300354" "issn" => "15782190" "doi" => "10.1016/j.adengl.2018.09.022" "estado" => "S300" "fechaPublicacion" => "2020-04-01" "aid" => "2257" "copyright" => "AEDV" "documento" => "simple-article" "crossmark" => 1 "licencia" => "http://creativecommons.org/licenses/by-nc-nd/4.0/" "subdocumento" => "crp" "cita" => "Actas Dermosifiliogr. 2020;111:257-60" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "en" => array:13 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">E-Brief Comunications</span>" "titulo" => "Prospective Study of Q Switched Alexandrite Laser 755 nm and V Beam Pulsed Dye Laser 595 nm in Dermatofibroma" "tienePdf" => "en" "tieneTextoCompleto" => "en" "tieneResumen" => array:2 [ 0 => "en" 1 => "es" ] "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "257" "paginaFinal" => "260" ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Estudio prospectivo de la combinación de láser de alejandrita Q-Switched de 755 nm y el láser V Beam de colorante pulsado de 595 nm en dermatofibromas" ] ] "contieneResumen" => array:2 [ "en" => true "es" => true ] "contieneTextoCompleto" => array:1 [ "en" => true ] "contienePdf" => array:1 [ "en" => true ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:8 [ "identificador" => "fig0005" "etiqueta" => "Figure 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 1369 "Ancho" => 1207 "Tamanyo" => 178929 ] ] "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at0005" "detalle" => "Figure " "rol" => "short" ] ] "descripcion" => array:1 [ "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">A, Dermatofibroma before treatment; B, Dermatofibroma after treatment; C, Before treatment, the dermatofibroma shows peripheral pigmentation accompanied by a white central patch; D, After treatment with the Q-Switched alexandrite laser with a wavelength of 755 nm, dermatoscopy of the dermatofibroma shows vascular structures and a white central patch; E, After treatment with the 595-nm pulsed dye laser, dermatoscopy of the dermatofibroma shows a white central patch.</p>" ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "A. 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DPP-4i indicates dipeptidyl peptidase 4 inhibitor.</p>" ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "J. Magdaleno-Tapial, C. Valenzuela-Oñate, Á. Esteban Hurtado, J.M. Ortiz-Salvador, D. Subiabre-Ferrer, B. Ferrer-Guillén, M. Giacaman-von der Weth, M. García-Legaz Martínez, Á. Martínez-Domenech, P. Hernández-Bel, A. Esteve-Martínez, G. Pérez-Pastor, V. Zaragoza-Ninet, A. García-Rabasco, A. Martínez-Aparicio, J.L. Sánchez-Carazo, A. Pérez-Ferriols, V. Alegre-de Miquel" "autores" => array:18 [ 0 => array:2 [ "nombre" => "J." "apellidos" => "Magdaleno-Tapial" ] 1 => array:2 [ "nombre" => "C." "apellidos" => "Valenzuela-Oñate" ] 2 => array:2 [ "nombre" => "Á." "apellidos" => "Esteban Hurtado" ] 3 => array:2 [ "nombre" => "J.M." "apellidos" => "Ortiz-Salvador" ] 4 => array:2 [ "nombre" => "D." "apellidos" => "Subiabre-Ferrer" ] 5 => array:2 [ "nombre" => "B." "apellidos" => "Ferrer-Guillén" ] 6 => array:2 [ "nombre" => "M." 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"apellidos" => "Alegre-de Miquel" ] ] ] ] ] "idiomaDefecto" => "en" "Traduccion" => array:1 [ "es" => array:9 [ "pii" => "S0001731019303655" "doi" => "10.1016/j.ad.2019.07.003" "estado" => "S300" "subdocumento" => "" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0001731019303655?idApp=UINPBA000044" ] ] "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1578219020300391?idApp=UINPBA000044" "url" => "/15782190/0000011100000003/v1_202005050702/S1578219020300391/v1_202005050702/en/main.assets" ] "en" => array:17 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Case for Diagnosis</span>" "titulo" => "White Plaques in the Oral Cavity" "tieneTextoCompleto" => true "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "255" "paginaFinal" => "256" ] ] "autores" => array:1 [ 0 => array:4 [ "autoresLista" => "E. Rojas Mora, R. Kheadaoui, A. Hernández-Núñez" "autores" => array:3 [ 0 => array:4 [ "nombre" => "E." "apellidos" => "Rojas Mora" "email" => array:1 [ 0 => "ester.rojas@salud.madrid.org" ] "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] 1 => array:2 [ "etiqueta" => "*" "identificador" => "cor0005" ] ] ] 1 => array:3 [ "nombre" => "R." "apellidos" => "Kheadaoui" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] ] ] 2 => array:3 [ "nombre" => "A." "apellidos" => "Hernández-Núñez" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] ] ] ] "afiliaciones" => array:2 [ 0 => array:3 [ "entidad" => "Servicio de Dermatología, Hospital Universitario de Fuenlabrada, Fuenlabrada, Madrid, Spain" "etiqueta" => "a" "identificador" => "aff0005" ] 1 => array:3 [ "entidad" => "Servicio de Anatomía Patológica, Hospital Universitario de Fuenlabrada, Fuenlabrada, Madrid, Spain" "etiqueta" => "b" "identificador" => "aff0010" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "⁎" "correspondencia" => "Corresponding author." ] ] ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Placas blancas en cavidad oral" ] ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:8 [ "identificador" => "fig0005" "etiqueta" => "Figure 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 451 "Ancho" => 950 "Tamanyo" => 56912 ] ] "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at0005" "detalle" => "Figure " "rol" => "short" ] ] "descripcion" => array:1 [ "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">.</p>" ] ] ] "textoCompleto" => "<span class="elsevierStyleSections"><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0005">Medical History</span><p id="par0005" class="elsevierStylePara elsevierViewall">A 9-year-old boy with a past history of atopic dermatitis and attention deficit and hyperactivity disorder, who was undergoing treatment with methylphenidate and risperidone, visited our department with asymptomatic lesions in the oral cavity that had appeared 7 months earlier; the lesions had been treated with topical antifungal agents (ketoconazole and nystatin), with no improvement.</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0010">Physical Examination</span><p id="par0010" class="elsevierStylePara elsevierViewall">Thick, rough, white plaques that did not detach on scraping were found in the oral cavity, involving the mucosa of both cheeks, the floor of the mouth, and the lateral edges and ventral region of the tongue (<a class="elsevierStyleCrossRef" href="#fig0005">Fig. 1</a>). The rest of the physical examination was normal.</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia></span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0015">Histopathology</span><p id="par0015" class="elsevierStylePara elsevierViewall">An incisional biopsy of the buccal mucosa was taken. Staining with hematoxylin–eosin revealed a squamous mucosa with acanthosis and clear cells corresponding to keratinocytes with abundant clear cytoplasm and a small nucleus and foci of a perinuclear cytoplasmic eosinophilic material. The cell wall showed no inflammatory infiltrate (<a class="elsevierStyleCrossRef" href="#fig0010">Fig. 2</a>). PAS staining revealed no mycotic structures.</p><elsevierMultimedia ident="fig0010"></elsevierMultimedia></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0020">Other Tests</span><p id="par0020" class="elsevierStylePara elsevierViewall">Mycology culture was negative. Blood tests revealed elevated urea (356 mg/dL), and other biochemistry parameters, blood count, complement, and immunoglobulin levels were normal. The serologic study (EBV, <span class="elsevierStyleItalic">Mycoplasma pneumoniae</span>, parvovirus B19, CMV) showed findings compatible with past infection (IgG positive) by EBV and Parvovirus B19.</p><p id="par0025" class="elsevierStylePara elsevierViewall">[[?]]What is your diagnosis?</p></span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0025">Diagnosis</span><p id="par0030" class="elsevierStylePara elsevierViewall">White sponge nevus.</p></span><span id="sec0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0030">Clinical Course and Treatment</span><p id="par0035" class="elsevierStylePara elsevierViewall">A wait-and-see approach was adopted due to the benign nature of this entity. The patient is currently being studied for high urea levels at a metabolic diseases department.</p></span><span id="sec0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0035">Comment</span><p id="par0040" class="elsevierStylePara elsevierViewall">White sponge nevus is a rare, autosomal dominant hereditary genodermatosis with variable penetrance, although sporadic cases have been reported. It was described by Hyde in 1909 with the name leukokeratosis and in 1935, Cannon coined the term <span class="elsevierStyleItalic">white sponge nevus</span>.</p><p id="par0045" class="elsevierStylePara elsevierViewall">The pathophysiology is not fully understood. Mutations have been identified in the genes that code for keratins 3 and 14, located on chromosomes 12q13 and 17q21‐q22, respectively. These keratins are expressed specifically in the buccal, anogenital, nasal, esophageal, and laryngeal mucosa, and in other nonkeratinized stratified squamous epithelia.<a class="elsevierStyleCrossRefs" href="#bib0005"><span class="elsevierStyleSup">1–4</span></a></p><p id="par0050" class="elsevierStylePara elsevierViewall">Lesions are asymptomatic in most cases and tend to involve the buccal mucosa bilaterally and symmetrically, in the form of white plaques with a rough, spongy appearance, which do not detach on scraping. Rare cases of isolated involvement of the extraoral mucosa have been reported.<a class="elsevierStyleCrossRef" href="#bib0025"><span class="elsevierStyleSup">5</span></a> They may be congenital or appear during childhood, as in the case of our patient. They sometimes appear during adolescence and show no preference for sex.<a class="elsevierStyleCrossRefs" href="#bib0005"><span class="elsevierStyleSup">1,3,5,6</span></a></p><p id="par0055" class="elsevierStylePara elsevierViewall">Histopathology is nonspecific. Of note is the epithelial thickening with parakeratotic hyperkeratosis, acanthosis, and spongiosis, with vacuolization of supra-epidermal keratinocytes and with perinuclear eosinophilic aggregates that correspond to anomalous groupings of keratin tonofilaments.<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a></p><p id="par0060" class="elsevierStylePara elsevierViewall">Diagnosis is based on clinical signs and symptoms and on histopathology findings. A genetic study may also be performed.</p><p id="par0065" class="elsevierStylePara elsevierViewall">Prognosis is good. Cases have been reported in the literature with subsequent development of dysplasia and even epidermoid carcinoma, although the link has not been clearly established.<a class="elsevierStyleCrossRefs" href="#bib0015"><span class="elsevierStyleSup">3,5</span></a></p><p id="par0070" class="elsevierStylePara elsevierViewall">Treatment is not required, as the lesions are asymptomatic. Isolated cases of response to chlorhexidine, topical retinoids and topical tetracycline, and oral penicillin have been published.<a class="elsevierStyleCrossRefs" href="#bib0005"><span class="elsevierStyleSup">1,2,6</span></a></p><p id="par0075" class="elsevierStylePara elsevierViewall">The differential diagnosis must be carried out with other diseases that involve white lesions in the buccal mucosa, such as genodermatosis (congenital pachyonychia, hereditary benign intraepithelial dyskeratosis, and congenital dyskeratosis), infections (oral candidiasis in its pseudomembranous form, focal epithelial hyperplasia, and syphilis), inflammatory diseases (lichen planus), premalignant and malignant lesions (leukoplasia, epidermoid carcinoma), and other entities such as leukoedema and friction hyperkeratosis.</p><p id="par0080" class="elsevierStylePara elsevierViewall">We report a rare, extensive case of pediatric-onset white sponge nevus. Of note in our patient is the casual finding of high levels of urea and suspected underlying metabolic disease, a finding not reported to date. The link between the 2 entities has yet to be defined.</p></span><span id="sec0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0040">Conflicts of Interest</span><p id="par0085" class="elsevierStylePara elsevierViewall">The authors declare that they have no conflicts of interest.</p></span></span>" "textoCompletoSecciones" => array:1 [ "secciones" => array:9 [ 0 => array:2 [ "identificador" => "sec0005" "titulo" => "Medical History" ] 1 => array:2 [ "identificador" => "sec0010" "titulo" => "Physical Examination" ] 2 => array:2 [ "identificador" => "sec0015" "titulo" => "Histopathology" ] 3 => array:2 [ "identificador" => "sec0020" "titulo" => "Other Tests" ] 4 => array:2 [ "identificador" => "sec0025" "titulo" => "Diagnosis" ] 5 => array:2 [ "identificador" => "sec0030" "titulo" => "Clinical Course and Treatment" ] 6 => array:2 [ "identificador" => "sec0035" "titulo" => "Comment" ] 7 => array:2 [ "identificador" => "sec0040" "titulo" => "Conflicts of Interest" ] 8 => array:1 [ "titulo" => "References" ] ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2018-02-10" "fechaAceptado" => "2018-09-09" "NotaPie" => array:1 [ 0 => array:2 [ "etiqueta" => "☆" "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Please cite this article as: Rojas Mora E, Kheadaoui R, Hernández-Núñez A, Placas blancas en cavidad oral. Actas Dermosifiliogr. 2020;111:255–256.</p>" ] ] "multimedia" => array:2 [ 0 => array:8 [ "identificador" => "fig0005" "etiqueta" => "Figure 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 451 "Ancho" => 950 "Tamanyo" => 56912 ] ] "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at0005" "detalle" => "Figure " "rol" => "short" ] ] "descripcion" => array:1 [ "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">.</p>" ] ] 1 => array:8 [ "identificador" => "fig0010" "etiqueta" => "Figure 2" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr2.jpeg" "Alto" => 715 "Ancho" => 950 "Tamanyo" => 275785 ] ] "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at0010" "detalle" => "Figure " "rol" => "short" ] ] "descripcion" => array:1 [ "en" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">A, Hematoxylin–eosin, ×40; B, Hematoxylin–eosin, ×100; C, Hematoxylin–eosin, ×200; D, Hematoxylin–eosin, ×400.</p>" ] ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:6 [ 0 => array:3 [ "identificador" => "bib0005" "etiqueta" => "1" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "White sponge nevus: report of a case and review of the literature" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "M. 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año/Mes | Html | Total | |
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2024 Noviembre | 16 | 16 | 32 |
2024 Octubre | 91 | 43 | 134 |
2024 Septiembre | 108 | 33 | 141 |
2024 Agosto | 143 | 70 | 213 |
2024 Julio | 120 | 35 | 155 |
2024 Junio | 123 | 40 | 163 |
2024 Mayo | 100 | 44 | 144 |
2024 Abril | 113 | 33 | 146 |
2024 Marzo | 84 | 29 | 113 |
2024 Febrero | 102 | 42 | 144 |
2024 Enero | 92 | 32 | 124 |
2023 Diciembre | 95 | 25 | 120 |
2023 Noviembre | 123 | 34 | 157 |
2023 Octubre | 105 | 32 | 137 |
2023 Septiembre | 108 | 27 | 135 |
2023 Agosto | 67 | 15 | 82 |
2023 Julio | 99 | 41 | 140 |
2023 Junio | 60 | 19 | 79 |
2023 Mayo | 112 | 49 | 161 |
2023 Abril | 51 | 26 | 77 |
2023 Marzo | 74 | 54 | 128 |
2023 Febrero | 45 | 40 | 85 |
2023 Enero | 37 | 30 | 67 |
2022 Diciembre | 54 | 43 | 97 |
2022 Noviembre | 47 | 33 | 80 |
2022 Octubre | 53 | 28 | 81 |
2022 Septiembre | 35 | 35 | 70 |
2022 Agosto | 34 | 47 | 81 |
2022 Julio | 32 | 41 | 73 |
2022 Junio | 30 | 24 | 54 |
2022 Mayo | 75 | 39 | 114 |
2022 Abril | 61 | 34 | 95 |
2022 Marzo | 61 | 55 | 116 |
2022 Febrero | 47 | 24 | 71 |
2022 Enero | 67 | 46 | 113 |
2021 Diciembre | 51 | 42 | 93 |
2021 Noviembre | 47 | 49 | 96 |
2021 Octubre | 90 | 52 | 142 |
2021 Septiembre | 45 | 48 | 93 |
2021 Agosto | 42 | 32 | 74 |
2021 Julio | 36 | 26 | 62 |
2021 Junio | 43 | 30 | 73 |
2021 Mayo | 48 | 39 | 87 |
2021 Abril | 100 | 46 | 146 |
2021 Marzo | 57 | 27 | 84 |
2021 Febrero | 31 | 22 | 53 |
2021 Enero | 53 | 18 | 71 |
2020 Diciembre | 54 | 19 | 73 |
2020 Noviembre | 34 | 11 | 45 |
2020 Octubre | 29 | 11 | 40 |
2020 Septiembre | 67 | 20 | 87 |
2020 Agosto | 52 | 20 | 72 |
2020 Julio | 17 | 12 | 29 |
2020 Junio | 47 | 33 | 80 |
2020 Mayo | 61 | 40 | 101 |
2020 Abril | 16 | 10 | 26 |