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    "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">Most of us finished medical school repeating the mantra &#8220;herpes simplex type 1 &#40;HSV-1&#41;<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>orolabial herpes&#59; herpes simplex type 2 &#40;HSV-2&#41;<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>genital herpes&#8221;&#46; However&#44; the passage of time has taught us that this is not always the case and that HSV-1 is increasingly found in the anogenital area&#44; as reported by Magdaleno et al&#46;<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a> In their observational study in a sexually transmitted infections unit in Valencia&#44; the authors found that 47&#46;3&#37; of cases of genital herpes were caused by HSV-1 and that this type was even more frequent in women &#40;59&#46;3&#37;&#41;&#46; Furthermore&#44; women with genital herpes caused by HSV-1 were younger than those with infection caused by HSV-2 &#40;26 vs&#46; 34 years&#44; respectively&#59; <span class="elsevierStyleItalic">P</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>&#46;015&#41;&#44; and infections caused by HSV-2 were more associated with recurrences than those caused by HSV-1&#46;</p><p id="par0010" class="elsevierStylePara elsevierViewall">The most recent studies estimate that the overall seroprevalence of HSV-2 infection is &#60;<span class="elsevierStyleHsp" style=""></span>10&#37; in Europe&#44; the eastern Mediterranean area&#44; Southeast Asia&#44; and parts of the western Pacific region&#46; Moreover&#44; it seems that this prevalence has been decreasing in our setting in recent years&#46;<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a> HSV-1&#44; on the other hand&#44; is currently confirmed as the most common cause of primary genital herpes infection in developed countries&#44; especially in women and in men who have sex with men aged under 25 years&#46;<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a> The reduced seroprevalence of HSV-1 has led us to consider a scenario in which adolescents and young adults first become exposed to HSV-1 at the onset of sexual activity&#46; Both this circumstance and the increasing frequency of unprotected oral-genital practices may help to explain why HSV-1 is more prevalent as the causal agent of genital herpes than HSV-2&#46; The resulting implications affect not only the epidemiology of the disease&#44; but also its prognosis&#44; since it seems that HSV-1 is associated with a lower frequency of recurrences&#46;</p></span>"
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Is Herpes Simplex Virus Type 2 in Danger of Extinction?
Herpes simple tipo 2: ¿en peligro de extinción?
R. Taberner
Servicio de Dermatología, Hospital Son Llàtzer, Palma, Illes Balears, Spain
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                            3 => "J&#46;M&#46; Ortiz-salvador"
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