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Yellowish-brown desquamation corresponding to seborrhoeic eczema was also observed &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>&#41;&#46;</p><p id="par0020" class="elsevierStylePara elsevierViewall">An excisional biopsy was performed&#46; Subsequent histopathology revealed 2&#160;distinct histological patterns&#46; The first&#44; more superficial pattern corresponded to a dermal tumor composed of multiple basophilic nodules formed by strands of dark basaloid cells and larger cells with pale nuclei&#46; Ductal structures were also observed inside the lobes&#44; as well as hyaline drops and squamous corpuscles &#40;<a class="elsevierStyleCrossRef" href="#fig0010">Fig&#46; 2</a>&#41;&#46;</p><elsevierMultimedia ident="fig0010"></elsevierMultimedia><p id="par0025" class="elsevierStylePara elsevierViewall">The second pattern&#44; observed in the deepest part of the lesion&#44; consisted of irregular strands of basophilic cells arranged in a checkerboard pattern and surrounded by eosinophilic hyaline bands &#40;<a class="elsevierStyleCrossRef" href="#fig0010">Fig&#46; 2</a>&#41;&#46; Based on these findings a diagnosis of spiradenocylindroma was established&#46;</p><p id="par0030" class="elsevierStylePara elsevierViewall">Spiradenoma&#44; first described by Kersting and Helwing in 1956&#44;<span class="elsevierStyleSup">1</span> is more frequent in females aged 15 to 35 years&#46; The clinical presentation consists of a single&#44; soft&#44; bluish nodule of 1&#160;cm to 2&#160;cm in diameter that is painful on palpation and is typically located on the trunk or neck&#46;<a class="elsevierStyleCrossRefs" href="#bib0065"><span class="elsevierStyleSup">1&#44;2</span></a> In 2015 Sahin<a class="elsevierStyleCrossRef" href="#bib0075"><span class="elsevierStyleSup">3</span></a> reported the following dermoscopic features of this lesion&#58; bluish pigmentation&#44; varied vascular structures&#44; and reticulated pigmentation at the lesion periphery&#46; In the same year Ankad and coworkers<a class="elsevierStyleCrossRef" href="#bib0080"><span class="elsevierStyleSup">4</span></a> described the trichoscopic features of spiradenoma&#44; including the presence of red serpentine linear structures surrounded by whitish areas&#46;</p><p id="par0035" class="elsevierStylePara elsevierViewall">The term cylindroma was first used by Billroth in 1856 to describe a benign adnexal tumor that mainly affects women aged 20 to 30 years&#46;<a class="elsevierStyleCrossRefs" href="#bib0085"><span class="elsevierStyleSup">5&#44;6</span></a> Cylindroma presents as a firm&#44; pink nodule located on the face or scalp&#44; usually grows slowly&#44; and has a mean size of 2<span class="elsevierStyleHsp" style=""></span>mm to 6&#160;mm&#46;<a class="elsevierStyleCrossRef" href="#bib0095"><span class="elsevierStyleSup">7</span></a> Reported dermoscopic patterns include arboriform vessels on a whitish&#44; salmon-pink background&#44; blue dots and globules&#44; and ulceration&#46;<a class="elsevierStyleCrossRefs" href="#bib0100"><span class="elsevierStyleSup">8&#44;9</span></a></p><p id="par0040" class="elsevierStylePara elsevierViewall">Spiradenoma and cylindroma are neoplasms of controversial histogenesis&#46; Historically&#44; spiradenoma has been considered a tumor of eccrine differentiation&#46; However&#44; its association with trichoepitheliomas in Brooke-Spiegler syndrome and with milium cysts in Rasmussen syndrome suggests a probable apocrine origin&#46; Cylindroma was originally considered an apocrine tumor&#46; Recent studies have revealed apocrine and eccrine characteristics in both tumor types&#46; Some authors even claim that these tumors are derived from the follicular epithelium&#44; since they are positive for CD200&#44; an immunohistochemical marker of hair-follicle stem cells&#46;<a class="elsevierStyleCrossRefs" href="#bib0085"><span class="elsevierStyleSup">5&#44;10</span></a></p><p id="par0045" class="elsevierStylePara elsevierViewall">While co-occurrence of both neoplasms in the same patient has been previously reported&#44; coexistence within the same clinical lesion is highly unusual&#46; Meybehm and Fischer proposed the term spiradenocylindroma for this particular presentation&#46;<a class="elsevierStyleCrossRef" href="#bib0115"><span class="elsevierStyleSup">11</span></a></p><p id="par0050" class="elsevierStylePara elsevierViewall">Spiradenocylindroma presents as a benign tumor&#44; which can be solitary or&#44; in the case of Brooke-Spiegler syndrome&#44; multiple&#46; Physical examination of our patient&#44; who had no family history of interest&#44; revealed a solitary lesion and no other pathological findings&#46;<a class="elsevierStyleCrossRefs" href="#bib0110"><span class="elsevierStyleSup">10&#44;11</span></a></p><p id="par0055" class="elsevierStylePara elsevierViewall">The dermoscopic features of spiradenocylindroma have not been previously described&#46; In our case&#44; the main dermoscopic findings were areas with salmon-pink coloration&#44; linear vessels&#44; and the presence at the lesion periphery of structures with a homogeneous blue coloration &#40;<a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a>&#41;&#46;</p><elsevierMultimedia ident="tbl0005"></elsevierMultimedia><p id="par0060" class="elsevierStylePara elsevierViewall">We have reported this case to share our finding of a very rare adnexal tumor and to describe the dermoscopic features of spiradenocylindroma&#46;</p><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0005">Conflicts of Interest</span><p id="par0065" class="elsevierStylePara elsevierViewall">The authors declare that they have no conflicts of interest&#46;</p></span></span>"
    "textoCompletoSecciones" => array:1 [
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          "identificador" => "sec0005"
          "titulo" => "Conflicts of Interest"
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          "identificador" => "xack423720"
          "titulo" => "Acknowledgments"
        ]
        2 => array:1 [
          "titulo" => "References"
        ]
      ]
    ]
    "pdfFichero" => "main.pdf"
    "tienePdf" => true
    "fechaRecibido" => "2017-11-27"
    "fechaAceptado" => "2018-03-09"
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      0 => array:2 [
        "etiqueta" => "&#9734;"
        "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Please cite this article as&#58; Senarega A&#46; Espiroadenocilindroma&#58; hallazgos dermatosc&#243;picos&#46; 2019&#59;110&#58;604&#8211;606&#46;</p>"
      ]
    ]
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          0 => array:4 [
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        "descripcion" => array:1 [
          "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">A&#44; Skin-colored nodule on which a bluish papule is located&#46; B&#44; Dermoscopy showing a salmon-pink area&#44; linear vessels&#44; and homogeneous blue pigmentation&#46;</p>"
        ]
      ]
      1 => array:7 [
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        "etiqueta" => "Figure 2"
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        "figura" => array:1 [
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          "en" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">A&#44; Spiradenoma &#40;&#42;&#41; and cylindroma &#40;&#43;&#41; within a single lesion &#40;hematoxylin-eosin&#44; original magnification &#215;40&#41;&#46; B&#44; Spiradenoma&#58; upper portion of the lesion consisting of cells with small hyperchromatic nuclei and others with large&#44; pale nuclei &#40;hematoxylin-eosin&#44; original magnification &#215;400&#41;&#46; C&#44; Cylindroma&#58; lower portion of the lesion consisting of tumoral nests arranged in a checkerboard pattern and surrounded by hyaline bands &#40;hematoxylin-eosin&#44; original magnification &#215;400&#41;&#46;</p>"
        ]
      ]
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                0 => """
                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Spiradenoma&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Cylindroma&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Spiradenocylindroma&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Age at presentation&#44; y&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">15&#8211;35<a class="elsevierStyleCrossRef" href="#bib0065"><span class="elsevierStyleSup">1</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">20&#8211;30<a class="elsevierStyleCrossRef" href="#bib0090"><span class="elsevierStyleSup">6</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">20&#8211;73<a class="elsevierStyleCrossRef" href="#bib0120"><span class="elsevierStyleSup">12</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
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                  \t\t\t\t">Clinical appearance&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">Soft bluish nodule&#44; painful on palpation&#44; located on the trunk and neck&#46;<a class="elsevierStyleCrossRefs" href="#bib0065"><span class="elsevierStyleSup">1&#44;2</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Firm&#44; pink nodule located on the face or scalp&#46;<a class="elsevierStyleCrossRef" href="#bib0095"><span class="elsevierStyleSup">7</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Solitary or multiple lesions&#46; Frequently associated with Brooke-Spiegler syndrome&#46;<a class="elsevierStyleCrossRef" href="#bib0120"><span class="elsevierStyleSup">12</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Histology&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">Nodules composed of 2 cell types&#58; small hyperchromatic cells and other larger cells with pale nuclei and ductal differentiation&#46; Thin basal membrane&#46;Frequent lymphocytic infiltration&#46;<a class="elsevierStyleCrossRef" href="#bib0110"><span class="elsevierStyleSup">10</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">Small lobules of basaloid cells arranged in a checkerboard pattern and surrounded by a prominent hyaline basement membrane&#46;Positive periodic acid-Schiff staining&#46; Absence of inflammatory infiltrate&#46;<a class="elsevierStyleCrossRef" href="#bib0110"><span class="elsevierStyleSup">10</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">Two distinct histological patterns within the same lesion&#46;<a class="elsevierStyleCrossRef" href="#bib0110"><span class="elsevierStyleSup">10</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t">Dermoscopic features&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">Light blue pigment with peripheral reticulate pigmentation&#44; associated with reddish linear serpentine structures surrounded by whitish areas&#46;<a class="elsevierStyleCrossRefs" href="#bib0075"><span class="elsevierStyleSup">3&#44;4</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">Blue dots and globules associated with arboriform vessels on a whitish&#44; salmon-pink background&#46;<a class="elsevierStyleCrossRefs" href="#bib0100"><span class="elsevierStyleSup">8&#44;9</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">Salmon-pink areas&#44; linear vessels&#44; and peripheral structures with homogeneous blue pigmentation&#46;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
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          "en" => "<p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">Differential Diagnosis of Spiradenoma&#44; Cylindroma&#44; and Spiradenocylindroma</p>"
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                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
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                  "contribucion" => array:1 [
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                  "contribucion" => array:1 [
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                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "N&#46; Rajan"
                            1 => "J&#46;A&#46; Langtry"
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                        "fecha" => "2015"
                        "volumen" => "54"
                        "paginaInicial" => "275"
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                        0 => array:2 [
                          "etal" => false
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                            1 => "D&#46;J&#46; Elpern"
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                    0 => array:1 [
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Case and Research Letters
Dermoscopic Features of Spiradenocylindroma
Espiroadenocilindroma: hallazgos dermatoscópicos
A. Senaregaa,
Autor para correspondencia
adrianasenarega@hotmail.com

Corresponding author.
, L. Floresa,b, A.C. Innocentia, V. Parraa,b
a Servicio de Dermatología, Hospital Luis Lagomaggiore, Mendoza, Argentina
b Facultad de Ciencias Médicas, Universidad Nacional de Cuyo, Mendoza, Argentina
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        "afiliaciones" => array:2 [
          0 => array:3 [
            "entidad" => "Servicio de Dermatolog&#237;a&#44; Hospital Luis Lagomaggiore&#44; Mendoza&#44; Argentina"
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          1 => array:3 [
            "entidad" => "Facultad de Ciencias M&#233;dicas&#44; Universidad Nacional de Cuyo&#44; Mendoza&#44; Argentina"
            "etiqueta" => "b"
            "identificador" => "aff0010"
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    "titulosAlternativos" => array:1 [
      "es" => array:1 [
        "titulo" => "Espiroadenocilindroma&#58; hallazgos dermatosc&#243;picos"
      ]
    ]
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          "en" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">A&#44; Spiradenoma &#40;&#42;&#41; and cylindroma &#40;&#43;&#41; within a single lesion &#40;hematoxylin-eosin&#44; original magnification &#215;40&#41;&#46; B&#44; Spiradenoma&#58; upper portion of the lesion consisting of cells with small hyperchromatic nuclei and others with large&#44; pale nuclei &#40;hematoxylin-eosin&#44; original magnification &#215;400&#41;&#46; C&#44; Cylindroma&#58; lower portion of the lesion consisting of tumoral nests arranged in a checkerboard pattern and surrounded by hyaline bands &#40;hematoxylin-eosin&#44; original magnification &#215;400&#41;&#46;</p>"
        ]
      ]
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    "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">Benign cutaneous adnexal tumors are a heterogeneous group of uncommon lesions that includes spiradenoma and cylindroma&#46; We report a case of coexisting spiradenoma and cylindroma and describe the corresponding dermoscopic findings&#46;</p><p id="par0010" class="elsevierStylePara elsevierViewall">A 37-year-old woman with no known medical history of interest was seen for an asymptomatic scalp lesion that was located on the hairline and had appeared 6 months earlier&#46; Physical examination revealed a soft&#44; rounded&#44; skin-colored nodule &#40;1&#160;cm in diameter&#41;&#44; upon which was a bluish&#44; hard-elastic papule &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>&#41;&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><p id="par0015" class="elsevierStylePara elsevierViewall">Dermoscopy revealed a salmon-pink area containing linear vessels on the lesion surface and the presence at the lesion periphery of associated structures with homogeneous blue coloration&#46; Yellowish-brown desquamation corresponding to seborrhoeic eczema was also observed &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>&#41;&#46;</p><p id="par0020" class="elsevierStylePara elsevierViewall">An excisional biopsy was performed&#46; Subsequent histopathology revealed 2&#160;distinct histological patterns&#46; The first&#44; more superficial pattern corresponded to a dermal tumor composed of multiple basophilic nodules formed by strands of dark basaloid cells and larger cells with pale nuclei&#46; Ductal structures were also observed inside the lobes&#44; as well as hyaline drops and squamous corpuscles &#40;<a class="elsevierStyleCrossRef" href="#fig0010">Fig&#46; 2</a>&#41;&#46;</p><elsevierMultimedia ident="fig0010"></elsevierMultimedia><p id="par0025" class="elsevierStylePara elsevierViewall">The second pattern&#44; observed in the deepest part of the lesion&#44; consisted of irregular strands of basophilic cells arranged in a checkerboard pattern and surrounded by eosinophilic hyaline bands &#40;<a class="elsevierStyleCrossRef" href="#fig0010">Fig&#46; 2</a>&#41;&#46; Based on these findings a diagnosis of spiradenocylindroma was established&#46;</p><p id="par0030" class="elsevierStylePara elsevierViewall">Spiradenoma&#44; first described by Kersting and Helwing in 1956&#44;<span class="elsevierStyleSup">1</span> is more frequent in females aged 15 to 35 years&#46; The clinical presentation consists of a single&#44; soft&#44; bluish nodule of 1&#160;cm to 2&#160;cm in diameter that is painful on palpation and is typically located on the trunk or neck&#46;<a class="elsevierStyleCrossRefs" href="#bib0065"><span class="elsevierStyleSup">1&#44;2</span></a> In 2015 Sahin<a class="elsevierStyleCrossRef" href="#bib0075"><span class="elsevierStyleSup">3</span></a> reported the following dermoscopic features of this lesion&#58; bluish pigmentation&#44; varied vascular structures&#44; and reticulated pigmentation at the lesion periphery&#46; In the same year Ankad and coworkers<a class="elsevierStyleCrossRef" href="#bib0080"><span class="elsevierStyleSup">4</span></a> described the trichoscopic features of spiradenoma&#44; including the presence of red serpentine linear structures surrounded by whitish areas&#46;</p><p id="par0035" class="elsevierStylePara elsevierViewall">The term cylindroma was first used by Billroth in 1856 to describe a benign adnexal tumor that mainly affects women aged 20 to 30 years&#46;<a class="elsevierStyleCrossRefs" href="#bib0085"><span class="elsevierStyleSup">5&#44;6</span></a> Cylindroma presents as a firm&#44; pink nodule located on the face or scalp&#44; usually grows slowly&#44; and has a mean size of 2<span class="elsevierStyleHsp" style=""></span>mm to 6&#160;mm&#46;<a class="elsevierStyleCrossRef" href="#bib0095"><span class="elsevierStyleSup">7</span></a> Reported dermoscopic patterns include arboriform vessels on a whitish&#44; salmon-pink background&#44; blue dots and globules&#44; and ulceration&#46;<a class="elsevierStyleCrossRefs" href="#bib0100"><span class="elsevierStyleSup">8&#44;9</span></a></p><p id="par0040" class="elsevierStylePara elsevierViewall">Spiradenoma and cylindroma are neoplasms of controversial histogenesis&#46; Historically&#44; spiradenoma has been considered a tumor of eccrine differentiation&#46; However&#44; its association with trichoepitheliomas in Brooke-Spiegler syndrome and with milium cysts in Rasmussen syndrome suggests a probable apocrine origin&#46; Cylindroma was originally considered an apocrine tumor&#46; Recent studies have revealed apocrine and eccrine characteristics in both tumor types&#46; Some authors even claim that these tumors are derived from the follicular epithelium&#44; since they are positive for CD200&#44; an immunohistochemical marker of hair-follicle stem cells&#46;<a class="elsevierStyleCrossRefs" href="#bib0085"><span class="elsevierStyleSup">5&#44;10</span></a></p><p id="par0045" class="elsevierStylePara elsevierViewall">While co-occurrence of both neoplasms in the same patient has been previously reported&#44; coexistence within the same clinical lesion is highly unusual&#46; Meybehm and Fischer proposed the term spiradenocylindroma for this particular presentation&#46;<a class="elsevierStyleCrossRef" href="#bib0115"><span class="elsevierStyleSup">11</span></a></p><p id="par0050" class="elsevierStylePara elsevierViewall">Spiradenocylindroma presents as a benign tumor&#44; which can be solitary or&#44; in the case of Brooke-Spiegler syndrome&#44; multiple&#46; Physical examination of our patient&#44; who had no family history of interest&#44; revealed a solitary lesion and no other pathological findings&#46;<a class="elsevierStyleCrossRefs" href="#bib0110"><span class="elsevierStyleSup">10&#44;11</span></a></p><p id="par0055" class="elsevierStylePara elsevierViewall">The dermoscopic features of spiradenocylindroma have not been previously described&#46; In our case&#44; the main dermoscopic findings were areas with salmon-pink coloration&#44; linear vessels&#44; and the presence at the lesion periphery of structures with a homogeneous blue coloration &#40;<a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a>&#41;&#46;</p><elsevierMultimedia ident="tbl0005"></elsevierMultimedia><p id="par0060" class="elsevierStylePara elsevierViewall">We have reported this case to share our finding of a very rare adnexal tumor and to describe the dermoscopic features of spiradenocylindroma&#46;</p><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0005">Conflicts of Interest</span><p id="par0065" class="elsevierStylePara elsevierViewall">The authors declare that they have no conflicts of interest&#46;</p></span></span>"
    "textoCompletoSecciones" => array:1 [
      "secciones" => array:3 [
        0 => array:2 [
          "identificador" => "sec0005"
          "titulo" => "Conflicts of Interest"
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        1 => array:2 [
          "identificador" => "xack423720"
          "titulo" => "Acknowledgments"
        ]
        2 => array:1 [
          "titulo" => "References"
        ]
      ]
    ]
    "pdfFichero" => "main.pdf"
    "tienePdf" => true
    "fechaRecibido" => "2017-11-27"
    "fechaAceptado" => "2018-03-09"
    "NotaPie" => array:1 [
      0 => array:2 [
        "etiqueta" => "&#9734;"
        "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Please cite this article as&#58; Senarega A&#46; Espiroadenocilindroma&#58; hallazgos dermatosc&#243;picos&#46; 2019&#59;110&#58;604&#8211;606&#46;</p>"
      ]
    ]
    "multimedia" => array:3 [
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        "etiqueta" => "Figure 1"
        "tipo" => "MULTIMEDIAFIGURA"
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        "figura" => array:1 [
          0 => array:4 [
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        "descripcion" => array:1 [
          "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">A&#44; Skin-colored nodule on which a bluish papule is located&#46; B&#44; Dermoscopy showing a salmon-pink area&#44; linear vessels&#44; and homogeneous blue pigmentation&#46;</p>"
        ]
      ]
      1 => array:7 [
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        "etiqueta" => "Figure 2"
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        "mostrarFloat" => true
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        "figura" => array:1 [
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          "en" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">A&#44; Spiradenoma &#40;&#42;&#41; and cylindroma &#40;&#43;&#41; within a single lesion &#40;hematoxylin-eosin&#44; original magnification &#215;40&#41;&#46; B&#44; Spiradenoma&#58; upper portion of the lesion consisting of cells with small hyperchromatic nuclei and others with large&#44; pale nuclei &#40;hematoxylin-eosin&#44; original magnification &#215;400&#41;&#46; C&#44; Cylindroma&#58; lower portion of the lesion consisting of tumoral nests arranged in a checkerboard pattern and surrounded by hyaline bands &#40;hematoxylin-eosin&#44; original magnification &#215;400&#41;&#46;</p>"
        ]
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                0 => """
                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Spiradenoma&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Cylindroma&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Spiradenocylindroma&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Age at presentation&#44; y&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">15&#8211;35<a class="elsevierStyleCrossRef" href="#bib0065"><span class="elsevierStyleSup">1</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">20&#8211;30<a class="elsevierStyleCrossRef" href="#bib0090"><span class="elsevierStyleSup">6</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">20&#8211;73<a class="elsevierStyleCrossRef" href="#bib0120"><span class="elsevierStyleSup">12</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Clinical appearance&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">Soft bluish nodule&#44; painful on palpation&#44; located on the trunk and neck&#46;<a class="elsevierStyleCrossRefs" href="#bib0065"><span class="elsevierStyleSup">1&#44;2</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Firm&#44; pink nodule located on the face or scalp&#46;<a class="elsevierStyleCrossRef" href="#bib0095"><span class="elsevierStyleSup">7</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Solitary or multiple lesions&#46; Frequently associated with Brooke-Spiegler syndrome&#46;<a class="elsevierStyleCrossRef" href="#bib0120"><span class="elsevierStyleSup">12</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Histology&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">Nodules composed of 2 cell types&#58; small hyperchromatic cells and other larger cells with pale nuclei and ductal differentiation&#46; Thin basal membrane&#46;Frequent lymphocytic infiltration&#46;<a class="elsevierStyleCrossRef" href="#bib0110"><span class="elsevierStyleSup">10</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t">Small lobules of basaloid cells arranged in a checkerboard pattern and surrounded by a prominent hyaline basement membrane&#46;Positive periodic acid-Schiff staining&#46; Absence of inflammatory infiltrate&#46;<a class="elsevierStyleCrossRef" href="#bib0110"><span class="elsevierStyleSup">10</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">Two distinct histological patterns within the same lesion&#46;<a class="elsevierStyleCrossRef" href="#bib0110"><span class="elsevierStyleSup">10</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t">Dermoscopic features&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">Light blue pigment with peripheral reticulate pigmentation&#44; associated with reddish linear serpentine structures surrounded by whitish areas&#46;<a class="elsevierStyleCrossRefs" href="#bib0075"><span class="elsevierStyleSup">3&#44;4</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">Blue dots and globules associated with arboriform vessels on a whitish&#44; salmon-pink background&#46;<a class="elsevierStyleCrossRefs" href="#bib0100"><span class="elsevierStyleSup">8&#44;9</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">Salmon-pink areas&#44; linear vessels&#44; and peripheral structures with homogeneous blue pigmentation&#46;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
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      "titulo" => "References"
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        0 => array:2 [
          "identificador" => "bibs0015"
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            0 => array:3 [
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              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Eccrine spiradenoma"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "D&#46;W&#46; Kersting"
                            1 => "E&#46;B&#46; Helwig"
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                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "AMA Arch Derm&#46;"
                        "fecha" => "1956"
                        "volumen" => "7"
                        "paginaInicial" => "199"
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                      ]
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                  ]
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            1 => array:3 [
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                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "A rare case of eccrine spiradenoma-treatment and management"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "S&#46; Dhua"
                            1 => "D&#46;R&#46; Sekhar"
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                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1007/s00238-015-1103-4"
                      "Revista" => array:6 [
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                        "fecha" => "2016"
                        "volumen" => "39"
                        "paginaInicial" => "143"
                        "paginaFinal" => "146"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/27069311"
                            "web" => "Medline"
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                  ]
                ]
              ]
            ]
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              "identificador" => "bib0075"
              "etiqueta" => "3"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Dermoscopy of eccrine spiradenoma&#58; A case report"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "M&#46; &#350;ahin"
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                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:4 [
                        "tituloSerie" => "J Am Acad Dermatol&#46;"
                        "fecha" => "2015"
                        "volumen" => "72"
                        "paginaInicial" => "AB88"
                      ]
                    ]
                  ]
                ]
              ]
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            3 => array:3 [
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                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "A serpentine inside eccrine spiradenoma&#58; A new trichoscopic sign"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "B&#46;S&#46; Ankad"
                            1 => "S&#46;L&#46; Beergouder"
                            2 => "V&#46; Domble"
                            3 => "L&#46; Sujana"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.4103/0974-7753.153460"
                      "Revista" => array:6 [
                        "tituloSerie" => "Int J Trichology&#46;"
                        "fecha" => "2015"
                        "volumen" => "7"
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