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Un estudio poblacional" ] ] "contieneResumen" => array:2 [ "en" => true "es" => true ] "contieneTextoCompleto" => array:1 [ "en" => true ] "contienePdf" => array:1 [ "en" => true ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0005" "etiqueta" => "Figure 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 2097 "Ancho" => 2083 "Tamanyo" => 188333 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0055" class="elsevierStyleSimplePara elsevierViewall">Proportion of diagnosed cases of psoriasis by sex and age.</p>" ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "J.M. Fernández-Armenteros, X. Gómez-Arbonés, M. Buti-Solé, A. Betriu-Bars, V. Sanmartin-Novell, M. Ortega-Bravo, M. Martínez-Alonso, J.M. Casanova-Seuma" "autores" => array:8 [ 0 => array:2 [ "nombre" => "J.M." 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Nieto Rodríguez, E. Sendagorta Cudós, J.M. Rueda Carnero, P. Herranz Pinto" "autores" => array:4 [ 0 => array:4 [ "nombre" => "D. Nieto" "apellidos" => "Rodríguez" "email" => array:1 [ 0 => "dnr348@gmail.com" ] "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">⿎</span>" "identificador" => "cor0005" ] ] ] 1 => array:2 [ "nombre" => "E. Sendagorta" "apellidos" => "Cudós" ] 2 => array:2 [ "nombre" => "J.M. Rueda" "apellidos" => "Carnero" ] 3 => array:2 [ "nombre" => "P. Herranz" "apellidos" => "Pinto" ] ] "afiliaciones" => array:1 [ 0 => array:2 [ "entidad" => "Servicio de Dermatología, Hospital Universitario La Paz, Madrid, España" "identificador" => "aff0005" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "⿎" "correspondencia" => "Corresponding author." ] ] ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Presentación atípica de infección por virus de herpes simple tipo <span class="elsevierStyleSmallCaps">ii</span> (VHS <span class="elsevierStyleSmallCaps">II</span>) refractaria a tratamiento con aciclovir en 2 pacientes hematológicos" ] ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0020" "etiqueta" => "Figure 4" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr4.jpeg" "Alto" => 1317 "Ancho" => 2347 "Tamanyo" => 196778 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">Management of aciclovir-resistant genital herpes.</p>" ] ] ] "textoCompleto" => "<span class="elsevierStyleSections"><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0025">Introduction</span><p id="par0005" class="elsevierStylePara elsevierViewall">Infections by viruses in the Herpesviridae family are highly common in patients with hematologic diseases. Most of the infections seen in routine clinical practice are caused by viruses in the Alphaherpesvirinae subfamily, which includes herpes simplex virus (HSV) types 1 or 2 and the varicella zoster virus. Both the diagnosis and treatment of these infections are challenging because atypical presentations are common, as is resistance to the usual drugs (aciclovir, valaciclovir, and famciclovir). We report 2 cases of drug-resistant HSV-2 infection with unusual presentations in patients with hematologic diseases.</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0030">Case 1</span><p id="par0010" class="elsevierStylePara elsevierViewall">An 84-year-old woman with a history of arterial hypertension, type 2 diabetes mellitus, high cholesterol levels, and chronic lymphocytic leukemia was being followed but was not currently under treatment for the leukemia. She had received intravenous (iv) aciclovir for perianal and vulvar ulcers secondary to HSV-2 infection in 2015 and showed partial response. In March 2017 she was admitted with a new flare-up of the lesions. Physical examination revealed a wide area of ulceration with a fibrinous center, a foul-smelling exudate and erythematous borders distributed on the vulva, perianal area, and groin as well as over the lower abdomen and on the internal surfaces of the thighs (<a class="elsevierStyleCrossRef" href="#fig0005">Fig. 1</a>). A polymerase chain reaction (PCR) test was positive for HSV-2, and she was started on treatment with iv aciclovir, 10<span class="elsevierStyleHsp" style=""></span>mg/kg every 8<span class="elsevierStyleHsp" style=""></span>hours, and 1%<span class="elsevierStyleHsp" style=""></span>cidofovir cream once daily. After 10<span class="elsevierStyleHsp" style=""></span>days with no improvement, and given evidence of severe hypogammaglobulinemia, we infused a 0.4<span class="elsevierStyleHsp" style=""></span>g/kg dose of immunoglobulins, leaving the other treatments unchanged. The ulcers worsened, suggesting the likelihood of resistance to aciclovir. She was switched to iv foscarnet, 40<span class="elsevierStyleHsp" style=""></span>mg/kg every 8<span class="elsevierStyleHsp" style=""></span>hours, and 5%<span class="elsevierStyleHsp" style=""></span>imiquimod cream thrice weekly. The skin lesions began to improve gradually, but her general condition remained poor, with multiple complications related to foscarnet (low calcium, magnesium, phosphate, and potassium levels refractory to oral and intravenous supplements). She also suffered 2<span class="elsevierStyleHsp" style=""></span>urinary tract infections (one due to <span class="elsevierStyleItalic">Klebsiella pneumoniae</span> and the other to <span class="elsevierStyleItalic">Enterococcus faecium</span>) that resolved with antibiotic treatment. Renal function declined gradually and she experienced several episodes of exacerbated heart failure. It was decided to suspend intensive treatment for the HSV-2 infection and discharge her under treatment with 5%<span class="elsevierStyleHsp" style=""></span>imiquimod cream and oral valaciclovir. Three months later, the patient was brought to the emergency department, where she died due to sepsis arising from a urinary tract infection.</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia></span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0035">Case 2</span><p id="par0015" class="elsevierStylePara elsevierViewall">A 64-year-old woman with a history of follicular Hodgkin lymphoma treated with a bone marrow transplant had also had a prior HSV-2 infection. She complained of an exophytic perianal lesion (<a class="elsevierStyleCrossRef" href="#fig0010">Fig. 2</a>A). A biopsy to rule out perianal epidermoid carcinoma showed epidermal hyperplasia with multinucleated giant cells and epithelial cells with gray nuclei and marginal chromatin, consistent with herpesvirus infection (<a class="elsevierStyleCrossRef" href="#fig0015">Fig. 3</a>). A PCR test was positive for HSV-2, confirming a diagnosis of hypertrophic perianal herpes infection. She did not improve in 7<span class="elsevierStyleHsp" style=""></span>days on oral aciclovir (400<span class="elsevierStyleHsp" style=""></span>mg/4<span class="elsevierStyleHsp" style=""></span>h), but the growth resolved completely after an intralesional injection of cidofovir (0.3<span class="elsevierStyleHsp" style=""></span>mL) (<a class="elsevierStyleCrossRef" href="#fig0010">Fig. 2</a>B). Recurrences were frequent, however, so she was prescribed applications of 5%<span class="elsevierStyleHsp" style=""></span>imiquimod cream 3 times per week. Response was favorable and remained stable 3<span class="elsevierStyleHsp" style=""></span>months after applications began.</p><elsevierMultimedia ident="fig0010"></elsevierMultimedia><elsevierMultimedia ident="fig0015"></elsevierMultimedia></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0040">Discussion</span><p id="par0020" class="elsevierStylePara elsevierViewall">Herpesvirus infections are highly frequent in patients with hematologic diseases. The incidence varies from 15% in patients with chronic lymphocytic leukemia to 90% in patients with acute leukemia or those who have received a bone marrow transplant.<a class="elsevierStyleCrossRef" href="#bib0070"><span class="elsevierStyleSup">1</span></a> The clinical signs, which arise when a latent virus is reactivated, may take the form of ulcers in the mouth (85%–90%) or genital area (10%–15%); primary infections are unusual in this context.<a class="elsevierStyleCrossRef" href="#bib0075"><span class="elsevierStyleSup">2</span></a></p><p id="par0025" class="elsevierStylePara elsevierViewall">HSV-2 infections may present with chronic or atypical lesions in association with hematologic diseases<a class="elsevierStyleCrossRef" href="#bib0080"><span class="elsevierStyleSup">3</span></a> and clinical manifestations vary. Among them are generalized papular rashes, large ulcerations with geographic borders, linear erosive lesions, and vegetative herpes.<a class="elsevierStyleCrossRef" href="#bib0085"><span class="elsevierStyleSup">4</span></a> Lesions that progress like warts and can simulate neoplasia or lesions with necrotic plaques have also been reported.<a class="elsevierStyleCrossRef" href="#bib0090"><span class="elsevierStyleSup">5</span></a> Thus, a differential diagnosis requires consideration of multiple possibilities (<a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a>).</p><elsevierMultimedia ident="tbl0005"></elsevierMultimedia><p id="par0030" class="elsevierStylePara elsevierViewall">Hypertrophic herpes simplex virus infections usually present as painful exophytic tumors that sometimes form ulcers on the surface, suggesting differential diagnoses of human papillomavirus infection, secondary syphilis, or cancer (epidermoid carcinoma or lymphoma).<a class="elsevierStyleCrossRef" href="#bib0095"><span class="elsevierStyleSup">6</span></a> A biopsy usually shows a dense inflammatory infiltrate of plasma cells, lymphocytes and eosinophils, associated with variable degrees of epidermal hyperplasia with multinucleated giant cells that reveal the cytopathic effects of HSV infection (epithelial cells with gray nuclei and marginal chromatin).<a class="elsevierStyleCrossRef" href="#bib0100"><span class="elsevierStyleSup">7</span></a> The mechanism underlying this hypertrophic variant is unknown, but one hypothesis is an abnormal immune response mediated by type 2 helper T-cells that trigger overproduction of keratinocytes and fibroblasts.<a class="elsevierStyleCrossRefs" href="#bib0095"><span class="elsevierStyleSup">6,8</span></a></p><p id="par0035" class="elsevierStylePara elsevierViewall">HSV resistance to aciclovir is unusual in immunocompetent individuals (<<span class="elsevierStyleHsp" style=""></span>1%) but common in human immunodeficiency virus-infected individuals<a class="elsevierStyleCrossRef" href="#bib0110"><span class="elsevierStyleSup">9</span></a> (5.3%) or those with hematologic diseases.<a class="elsevierStyleCrossRef" href="#bib0075"><span class="elsevierStyleSup">2</span></a> Drug-resistant infections are fewer in patients who receive long-term prophylaxis after bone marrow transplants.<a class="elsevierStyleCrossRef" href="#bib0115"><span class="elsevierStyleSup">10</span></a> However, if reactivation persists, resistance becomes more common. Responsible for resistance in 95% of cases is diminished activation of aciclovir in infected cells because of lower levels of viral thymidine kinase.<a class="elsevierStyleCrossRef" href="#bib0075"><span class="elsevierStyleSup">2</span></a> All aciclovir-resistant strains are also resistant to valaciclovir and ganciclovir, and most are resistant to famciclovir. Intravenous foscarnet and iv or topical cidofovir offer alternatives in such cases because they are not activated by this enzyme. Phenotypic or genotypic HSV resistance to antiviral drugs can be detected with tests<a class="elsevierStyleCrossRef" href="#bib0120"><span class="elsevierStyleSup">11</span></a> such as the analysis of genes encoding thymidine kinase and viral DNA polymerase.<a class="elsevierStyleCrossRef" href="#bib0125"><span class="elsevierStyleSup">12</span></a> However, as such approaches are not available in most laboratories, clinicians rely on response to therapy to raise suspicion (<a class="elsevierStyleCrossRef" href="#fig0020">Fig. 4</a>).</p><elsevierMultimedia ident="fig0020"></elsevierMultimedia><p id="par0040" class="elsevierStylePara elsevierViewall">Patients with hypertrophic herpes simplex virus infections have lesions that are often refractory to first-line drugs, suggesting that they are probably harboring resistant strains because less of the drug is reaching the lesion or less is deposited in pseudotumoral tissue.<a class="elsevierStyleCrossRef" href="#bib0095"><span class="elsevierStyleSup">6</span></a> Imiquimod antagonizes Toll-like receptors, particularly Toll-like receptor 7, triggering the release of proinflammatory cytokines such as interferon-α, interleukin 6, or tumor necrosis factor. Using 5%<span class="elsevierStyleHsp" style=""></span>imiquimod cream 3<span class="elsevierStyleHsp" style=""></span>times per week has been reported to improve symptoms within a few weeks of application, causing few local side effects.<a class="elsevierStyleCrossRefs" href="#bib0095"><span class="elsevierStyleSup">6,13</span></a></p><p id="par0045" class="elsevierStylePara elsevierViewall">In conclusion, immune suppression derived from hematologic diseases leads to a high incidence of viral, fungal, and bacterial skin lesions that often present atypically. Clinical suspicion should be high when treating these patients in the interest of early diagnosis and in order to consider all treatment alternatives, given that the viral strains involved are fairly often resistant to first-line drugs.</p></span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0045">Ethical Disclosures</span><span id="sec0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0050">Protection of human and animal subjects.</span><p id="par0050" class="elsevierStylePara elsevierViewall">The authors declare that no experiments were performed on humans or animals during the course of this study.</p></span><span id="sec0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0055">Data confidentiality.</span><p id="par0055" class="elsevierStylePara elsevierViewall">The authors declare that they followed their hospitals’ regulations regarding the publication of patient information and that written informed consent for voluntary participation was obtained for all patients.</p></span><span id="sec0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0060">Right to privacy and informed consent</span><p id="par0060" class="elsevierStylePara elsevierViewall">The authors declare that no patient data appear in this article.</p></span></span><span id="sec0045" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0065">Conflicts of Interest</span><p id="par0065" class="elsevierStylePara elsevierViewall">The authors declare that they have no conflicts of interest.</p></span></span>" "textoCompletoSecciones" => array:1 [ "secciones" => array:11 [ 0 => array:3 [ "identificador" => "xres1199781" "titulo" => "Abstract" "secciones" => array:1 [ 0 => array:1 [ "identificador" => "abst0005" ] ] ] 1 => array:2 [ "identificador" => "xpalclavsec1118223" "titulo" => "Keywords" ] 2 => array:3 [ "identificador" => "xres1199780" "titulo" => "Resumen" "secciones" => array:1 [ 0 => array:1 [ "identificador" => "abst0010" ] ] ] 3 => array:2 [ "identificador" => "xpalclavsec1118222" "titulo" => "Palabras clave" ] 4 => array:2 [ "identificador" => "sec0005" "titulo" => "Introduction" ] 5 => array:2 [ "identificador" => "sec0010" "titulo" => "Case 1" ] 6 => array:2 [ "identificador" => "sec0015" "titulo" => "Case 2" ] 7 => array:2 [ "identificador" => "sec0020" "titulo" => "Discussion" ] 8 => array:3 [ "identificador" => "sec0025" "titulo" => "Ethical Disclosures" "secciones" => array:3 [ 0 => array:2 [ "identificador" => "sec0030" "titulo" => "Protection of human and animal subjects." ] 1 => array:2 [ "identificador" => "sec0035" "titulo" => "Data confidentiality." ] 2 => array:2 [ "identificador" => "sec0040" "titulo" => "Right to privacy and informed consent" ] ] ] 9 => array:2 [ "identificador" => "sec0045" "titulo" => "Conflicts of Interest" ] 10 => array:1 [ "titulo" => "References" ] ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "PalabrasClave" => array:2 [ "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Keywords" "identificador" => "xpalclavsec1118223" "palabras" => array:9 [ 0 => "Genital herpes" 1 => "Hypertrophic herpes" 2 => "Leukemia" 3 => "Lymphoma" 4 => "Resistance" 5 => "Aciclovir" 6 => "Foscarnet" 7 => "Cidofovir" 8 => "Imiquimod" ] ] ] "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec1118222" "palabras" => array:9 [ 0 => "Herpes genital" 1 => "Herpes hipertrófico" 2 => "Leucemia" 3 => "Linfoma" 4 => "Resistencia" 5 => "Aciclovir" 6 => "Foscarnet" 7 => "Cidofovir" 8 => "Imiquimod" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "en" => array:2 [ "titulo" => "Abstract" "resumen" => "<span id="abst0005" class="elsevierStyleSection elsevierViewall"><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Herpesvirus infections are not uncommon in hematologic patients. Our first patient, diagnosed with chronic lymphatic leukemia, presented extensive genital herpes infection refractory to treatment with aciclovir and with a partial response to foscarnet, which had to be withdrawn due to systemic adverse effects. The second patient, diagnosed with follicular Hodgkin lymphoma, presented hypertrophic herpes infection refractory to treatment with aciclovir but that responded to intralesional cidofovir and topical imiquimod. As in other immunocompromised patients, herpesvirus infection in hematologic patients can present atypical manifestations, as well as resistance to treatments that are activated by the viral thymidine kinase. A high level of clinical suspicion is therefore needed to make an early diagnosis, together with extensive knowledge of the different treatments available.</p></span>" ] "es" => array:2 [ "titulo" => "Resumen" "resumen" => "<span id="abst0010" class="elsevierStyleSection elsevierViewall"><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Las infecciones por virus herpes presentan una frecuencia no desdeñable en pacientes hematológicos. El primer caso corresponde a una paciente con leucemia linfática crónica con un herpes genital extenso refractario a aciclovir, con respuesta parcial a foscarnet que hubo que suspender por efectos secundarios sistémicos. El segundo caso es el de una paciente con un linfoma de Hodgkin folicular que presentaba un herpes hipertrófico refractario a tratamiento con aciclovir, que respondió a cidofovir intralesional e imiquimod tópico. Los pacientes hematológicos, al igual que otros enfermos inmunodeprimidos, pueden presentar manifestaciones atípicas de infección por virus herpes, así como resistencia a los tratamientos que actúan por medio de la timidina quinasa viral. Esto hace necesario tener una alta sospecha clínica para poder alcanzar un diagnóstico precoz, y conocer los diferentes tratamientos alternativos disponibles.</p></span>" ] ] "NotaPie" => array:1 [ 0 => array:2 [ "etiqueta" => "☆" "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Please cite this article as: Rodríguez DN, Cudós ES, Carnero JMR, Pinto PH. Presentación atípica de infección por virus de herpes simple tipo <span class="elsevierStyleSmallCaps">ii</span> (VHS <span class="elsevierStyleSmallCaps">II</span>) refractaria a tratamiento con aciclovir en 2 pacientes hematológicos. Actas Dermosifiliogr. 2019;110:393–397.</p>" ] ] "multimedia" => array:5 [ 0 => array:7 [ "identificador" => "fig0005" "etiqueta" => "Figure 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 509 "Ancho" => 900 "Tamanyo" => 76291 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Case 1: Wide area of exudative ulcers with a fibrinous center and erythematous borders were observed around the vulva, in the groin, and over the lower abdomen.</p>" ] ] 1 => array:7 [ "identificador" => "fig0010" "etiqueta" => "Figure 2" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr2.jpeg" "Alto" => 1165 "Ancho" => 1300 "Tamanyo" => 201346 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">Case 2: A, An exophytic perianal lesion. B, Clinical outcome after an intralesional dose of cidofovir (0.3<span class="elsevierStyleHsp" style=""></span>mL).</p>" ] ] 2 => array:7 [ "identificador" => "fig0015" "etiqueta" => "Figure 3" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr3.jpeg" "Alto" => 905 "Ancho" => 1300 "Tamanyo" => 426765 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">Histologic features in Case 2. The arrow on the left marks an epithelial cell with a gray nucleus and marginal chromatin. The same features can be seen in the multinucleated epithelial cell marked by the arrow on the right. (Hematoxylin-eosin; original magnification, ×400).</p>" ] ] 3 => array:7 [ "identificador" => "fig0020" "etiqueta" => "Figure 4" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr4.jpeg" "Alto" => 1317 "Ancho" => 2347 "Tamanyo" => 196778 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">Management of aciclovir-resistant genital herpes.</p>" ] ] 4 => array:8 [ "identificador" => "tbl0005" "etiqueta" => "Table 1" "tipo" => "MULTIMEDIATABLA" "mostrarFloat" => true "mostrarDisplay" => false "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at1" "detalle" => "Table " "rol" => "short" ] ] "tabla" => array:2 [ "leyenda" => "<p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">Abbreviations: HPV, human papillomavirus; HSV-2, herpes simplex virus type 2.</p>" "tablatextoimagen" => array:1 [ 0 => array:2 [ "tabla" => array:1 [ 0 => """ <table border="0" frame="\n \t\t\t\t\tvoid\n \t\t\t\t" class=""><tbody title="tbody"><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " rowspan="5" align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Hypertrophic genital herpes</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><span class="elsevierStyleItalic">Infectious</span> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Genital wartsCondyloma lataTuberculosis \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><span class="elsevierStyleItalic">Tumors</span> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Neoplasms related to HPV infectionOther neoplasms (fibroma, leiomyoma, etc.) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><span class="elsevierStyleItalic">Vascular</span> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">External hemorrhoids \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><span class="elsevierStyleItalic">Physiological</span> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Skin tags \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><span class="elsevierStyleItalic">Dermatologic disease</span> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Pemphigus vegetansVegetative pyoderma gangrenosum. \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " rowspan="2" align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Linear erosive lesions</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><span class="elsevierStyleItalic">Traumatic</span> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t"> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><span class="elsevierStyleItalic">Dermatologic disease</span> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Lichen sclerosusErosive lichen planus \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " rowspan="6" align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Extensive, persistent genital ulcers</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><span class="elsevierStyleItalic">Tumors</span> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Squamous cell carcinomaOther neoplasms \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><span class="elsevierStyleItalic">Dermatologic disease</span> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Pyoderma gangrenosumPemphigus vulgarisBullous pemphigoidBenign familial pemphigusCicatricial pemphigoid \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><span class="elsevierStyleItalic">Traumatic</span> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">IrritantPressure ulcersBurnsLesions due to caustic substances \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><span class="elsevierStyleItalic">Infectious</span> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Bacterial (impetigo, gangrenous ecthyma)Fungal (extensive candidiasis, mucormycosis)Viral (cytomegalovirus, Epstein–Barr virus) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><span class="elsevierStyleItalic">Drug reaction</span> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Stevens–Johnson syndrome, toxic epidermal necrolysisErythema multiforme major \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><span class="elsevierStyleItalic">Systemic</span> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Behçet diseaseInflammatory bowel disease \t\t\t\t\t\t\n \t\t\t\t</td></tr></tbody></table> """ ] "imagenFichero" => array:1 [ 0 => "xTab2049334.png" ] ] ] ] "descripcion" => array:1 [ "en" => "<p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">Differential Diagnosis of HSV-2 Infections With Atypical Presentations</p>" ] ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0015" "bibliografiaReferencia" => array:13 [ 0 => array:3 [ "identificador" => "bib0070" "etiqueta" => "1" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Viral infections in patients with hematological malignancies" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "J.C. 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año/Mes | Html | Total | |
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2024 Noviembre | 14 | 21 | 35 |
2024 Octubre | 158 | 48 | 206 |
2024 Septiembre | 204 | 48 | 252 |
2024 Agosto | 201 | 96 | 297 |
2024 Julio | 226 | 51 | 277 |
2024 Junio | 215 | 51 | 266 |
2024 Mayo | 203 | 54 | 257 |
2024 Abril | 207 | 49 | 256 |
2024 Marzo | 240 | 45 | 285 |
2024 Febrero | 252 | 38 | 290 |
2024 Enero | 214 | 40 | 254 |
2023 Diciembre | 283 | 21 | 304 |
2023 Noviembre | 377 | 54 | 431 |
2023 Octubre | 342 | 49 | 391 |
2023 Septiembre | 305 | 46 | 351 |
2023 Agosto | 294 | 27 | 321 |
2023 Julio | 298 | 53 | 351 |
2023 Junio | 223 | 27 | 250 |
2023 Mayo | 342 | 34 | 376 |
2023 Abril | 314 | 30 | 344 |
2023 Marzo | 211 | 44 | 255 |
2023 Febrero | 181 | 40 | 221 |
2023 Enero | 152 | 46 | 198 |
2022 Diciembre | 180 | 55 | 235 |
2022 Noviembre | 140 | 63 | 203 |
2022 Octubre | 92 | 43 | 135 |
2022 Septiembre | 74 | 45 | 119 |
2022 Agosto | 40 | 56 | 96 |
2022 Julio | 34 | 49 | 83 |
2022 Junio | 48 | 54 | 102 |
2022 Mayo | 119 | 38 | 157 |
2022 Abril | 172 | 63 | 235 |
2022 Marzo | 192 | 84 | 276 |
2022 Febrero | 223 | 40 | 263 |
2022 Enero | 219 | 47 | 266 |
2021 Diciembre | 189 | 56 | 245 |
2021 Noviembre | 183 | 58 | 241 |
2021 Octubre | 163 | 78 | 241 |
2021 Septiembre | 153 | 49 | 202 |
2021 Agosto | 159 | 31 | 190 |
2021 Julio | 128 | 28 | 156 |
2021 Junio | 149 | 35 | 184 |
2021 Mayo | 191 | 48 | 239 |
2021 Abril | 471 | 47 | 518 |
2021 Marzo | 276 | 32 | 308 |
2021 Febrero | 206 | 28 | 234 |
2021 Enero | 166 | 21 | 187 |
2020 Diciembre | 143 | 18 | 161 |
2020 Noviembre | 95 | 17 | 112 |
2020 Octubre | 81 | 18 | 99 |
2020 Septiembre | 100 | 12 | 112 |
2020 Agosto | 73 | 10 | 83 |
2020 Julio | 61 | 19 | 80 |
2020 Junio | 55 | 26 | 81 |
2020 Mayo | 49 | 14 | 63 |
2020 Abril | 23 | 12 | 35 |
2020 Marzo | 21 | 14 | 35 |
2020 Febrero | 5 | 0 | 5 |