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    "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">Atopic dermatitis is the most frequent inflammatory skin disease in children and one for which we do not yet have standardized treatment guidelines&#46; Most children and adolescents have mild forms that are controlled with topical treatments&#46; However&#44; in moderate to severe cases that cannot be appropriately managed with topical treatments&#44; other options such as phototherapy or systemic treatment must be considered&#46; None of the classic systemic treatments &#40;ciclosporin&#44; azathioprine&#44; methotrexate&#44; mycophenolate mofetil&#41; include the indication for treatment of atopic dermatitis in children and adolescents in their summary of product characteristics&#46; In addition&#44; there are very few publications on pediatric patients to help us in clinical practice&#46;<a class="elsevierStyleCrossRefs" href="#bib0020"><span class="elsevierStyleSup">1&#44;2</span></a></p><p id="par0010" class="elsevierStylePara elsevierViewall">In the present issue&#44; Noguera-Morel et al&#46;<a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">3</span></a> provide a retrospective review of children with severe atopic dermatitis treated with azathioprine over a 10-year period &#40;2007-2017&#41; at Hospital Infantil Universitario Ni&#241;o Jes&#250;s&#44; Madrid&#44; Spain&#46; The retrospective review includes 11 patients with a mean age of 13 years &#40;range&#44; 8-18 years&#41;&#46; The authors highlight the effectiveness of the drug with complete or near-complete clearance in 7 of 9 patients at 12-16 weeks of treatment&#46; These findings are somewhat superior to those published elsewhere and similar to those reported for other immunosuppressants&#46; As for safety&#44; only 2 patients had to suspend treatment because of gastrointestinal adverse events&#46;</p><p id="par0015" class="elsevierStylePara elsevierViewall">The authors agree with other specialists that the main drawbacks are the time to response &#40;approximately 3 months&#41; and the need for close monitoring&#46; This publication advocates the use of azathioprine as a systemic treatment option in pediatric patients&#44; albeit not as a first-choice drug&#46;</p><p id="par0020" class="elsevierStylePara elsevierViewall">In the coming years&#44; the advent of new biologics for the treatment of atopic dermatitis in children will show us where classic immunosuppressants stand&#46;</p></span>"
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