E-Case for Diagnosis
Erythematous Papules on the Dorsum of the Hand
Pápulas eritematosas en dorso de mano
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Maldonado Seral, C. Gómez de Castro, B. Vivanco Allende" "autores" => array:3 [ 0 => array:4 [ "nombre" => "C." "apellidos" => "Maldonado Seral" "email" => array:1 [ 0 => "cmaldonadoseral@yahoo.es" ] "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">*</span>" "identificador" => "cor0005" ] ] ] 1 => array:3 [ "nombre" => "C." "apellidos" => "Gómez de Castro" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] ] ] 2 => array:3 [ "nombre" => "B." "apellidos" => "Vivanco Allende" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] ] ] ] "afiliaciones" => array:2 [ 0 => array:3 [ "entidad" => "Servicio de Dermatología, Hospital Universitario Central de Asturias, Oviedo, Asturias, Spain" "etiqueta" => "a" "identificador" => "aff0005" ] 1 => array:3 [ "entidad" => "Servicio de Anatomía Patológica, Hospital Universitario Central de Asturias, Oviedo, Asturias, Spain" "etiqueta" => "b" "identificador" => "aff0010" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "⁎" "correspondencia" => "Corresponding author." ] ] ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Pápulas eritematosas en dorso de mano" ] ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0010" "etiqueta" => "Figure 2" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr2.jpeg" "Alto" => 350 "Ancho" => 233 "Tamanyo" => 37586 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">A, Hematoxylin-eosin, magnification ×<span class="elsevierStyleHsp" style=""></span>10. B, Hematoxylin-eosin, magnification ×<span class="elsevierStyleHsp" style=""></span>20.</p>" ] ] ] "textoCompleto" => "<span class="elsevierStyleSections"><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0005">Case History</span><p id="par0005" class="elsevierStylePara elsevierViewall">A 54-year old man with a history of hepatic steatosis presented with stable, asymptomatic lesions on the back of his left hand. They had appeared approximately 10 years earlier, and he had lost the fifth finger of the same hand to an injury 15 years earlier.</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0010">Physical Examination</span><p id="par0010" class="elsevierStylePara elsevierViewall">Several papules about 5<span class="elsevierStyleHsp" style=""></span>to<span class="elsevierStyleHsp" style=""></span>6<span class="elsevierStyleHsp" style=""></span>mm in diameter and a reddish–violaceous oval plaque measuring 12<span class="elsevierStyleHsp" style=""></span>×<span class="elsevierStyleHsp" style=""></span>6<span class="elsevierStyleHsp" style=""></span>mm could be seen on physical examination of the back of the hand (<a class="elsevierStyleCrossRef" href="#fig0005">Fig. 1</a>). The lesions were slightly infiltrated, well defined, and smooth to the touch.</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia></span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0015">Histopathology</span><p id="par0015" class="elsevierStylePara elsevierViewall">Histopathologic examination showed epidermal acanthosis and many oblong or round small-caliber vessels in the superficial and mid dermis. The vessels were bordered by endothelial cells with prominent nuclei and numerous fibroblasts with angular nuclei among collagen bundles (<a class="elsevierStyleCrossRef" href="#fig0010">Fig. 2</a>A). Occasional multinucleated cells (<a class="elsevierStyleCrossRef" href="#fig0010">Fig. 2</a>B) were also seen.</p><elsevierMultimedia ident="fig0010"></elsevierMultimedia><p id="par0020" class="elsevierStylePara elsevierViewall">Immunohistochemistry revealed intense positive staining of elongated, multinucleated cells for factor XIIIa (<a class="elsevierStyleCrossRef" href="#fig0015">Fig. 3</a>), α<span class="elsevierStyleInf">1</span>-antitrypsin, and lysozyme. Staining with colloidal iron ruled out interstitial mucin deposition.</p><elsevierMultimedia ident="fig0015"></elsevierMultimedia></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0020">Additional Tests</span><p id="par0025" class="elsevierStylePara elsevierViewall">A blood work-up showed elevated glucose levels (151<span class="elsevierStyleHsp" style=""></span>mg/dL) and altered liver function (alanine transaminase, 111<span class="elsevierStyleHsp" style=""></span>U/L; and γ-glutamyltransferase, 182<span class="elsevierStyleHsp" style=""></span>U/L).</p><p id="par0030" class="elsevierStylePara elsevierViewall">What Is Your Diagnosis?</p></span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0025">Diagnosis</span><p id="par0035" class="elsevierStylePara elsevierViewall">Multinucleate cell angiohistiocytoma.</p></span><span id="sec0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0030">Clinical Course and Treatment</span><p id="par0040" class="elsevierStylePara elsevierViewall">Because the lesions were benign and asymptomatic, no treatment was given.</p></span><span id="sec0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0035">Comment</span><p id="par0045" class="elsevierStylePara elsevierViewall">Multinucleate cell angiohistiocytomas are uncommon, benign lesions of uncertain histogenesis. Clinical signs are small, asymptomatic reddish–violaceous papules in acral locations. The lesions are often persistent and typically appear in middle-aged women. Although generalized lesions have been described,<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">1</span></a> a bilateral presentation is rare.</p><p id="par0050" class="elsevierStylePara elsevierViewall">These angiohistiocytomas were first described by Smith and Wilson-Jones in 1985,<a class="elsevierStyleCrossRef" href="#bib0040"><span class="elsevierStyleSup">2</span></a> and at least 300 cases have since been reported,<a class="elsevierStyleCrossRef" href="#bib0045"><span class="elsevierStyleSup">3</span></a> documenting a clinical presentation of small, asymptomatic papules or erythematous–violaceous plaques that grow slowly, are slightly infiltrated, and cluster in a well-defined area. Dermoscopy may reveal whitish patches, finely reticulated areas, and diffuse, poorly defined reddish areas.</p><p id="par0055" class="elsevierStylePara elsevierViewall">The histogenesis of these lesions is uncertain. It is argued that they should be considered fibrohistiocytic tumors, instances of vascular proliferation, or a chronic inflammatory disorder with fibrohistiocytic and vascular hyperplasia.<a class="elsevierStyleCrossRef" href="#bib0050"><span class="elsevierStyleSup">4</span></a> Trauma has been suggested as a possible precipitating factor because acral zones are usually involved. A possible role for estrogenic receptors in the development of these lesions has also been hypothesized to explain why they develop mainly in women.<a class="elsevierStyleCrossRef" href="#bib0055"><span class="elsevierStyleSup">5</span></a></p><p id="par0060" class="elsevierStylePara elsevierViewall">Histologically, multinucleate cell angiohistiocytomas display a proliferation of capillaries and venules in the upper and mid dermis, prominent endothelial cells accompanied by an infiltrate of lymphocytes and multinucleated cells with angular outlines.The multinucleated interstitial cells express factor XIIIa, vimentin, lysozyme, α<span class="elsevierStyleInf">1</span>-antitrypsin, and CD68; multinucleated cells usually express only vimentin, although they may also stain for monocyte or macrophage markers.</p><p id="par0065" class="elsevierStylePara elsevierViewall">Differential clinical diagnosis should include granuloma annulare, lichen planus, lymphocytoma, insect bites, sarcoidosis, and Kaposi sarcoma. Differential histologic diagnosis should include dermatofibroma (especially in cases of atrophic vascular histiocytoma) and Kaposi and pseudo-Kaposi sarcomas.</p><p id="par0070" class="elsevierStylePara elsevierViewall">Treatment is usually unnecessary, as the course of disease is benign. However, the literature offers descriptions of good response to cryotherapy as well as argon, carbon dioxide, or 585-nm pulsed-dye laser treatments.<a class="elsevierStyleCrossRef" href="#bib0060"><span class="elsevierStyleSup">6</span></a> Surgical excision is also a reasonable step if cosmetic treatment is desired.</p></span><span id="sec0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0040">Conflicts of Interest</span><p id="par0075" class="elsevierStylePara elsevierViewall">The authors declare that they have no conflicts of interest.</p></span></span>" "textoCompletoSecciones" => array:1 [ "secciones" => array:9 [ 0 => array:2 [ "identificador" => "sec0005" "titulo" => "Case History" ] 1 => array:2 [ "identificador" => "sec0010" "titulo" => "Physical Examination" ] 2 => array:2 [ "identificador" => "sec0015" "titulo" => "Histopathology" ] 3 => array:2 [ "identificador" => "sec0020" "titulo" => "Additional Tests" ] 4 => array:2 [ "identificador" => "sec0025" "titulo" => "Diagnosis" ] 5 => array:2 [ "identificador" => "sec0030" "titulo" => "Clinical Course and Treatment" ] 6 => array:2 [ "identificador" => "sec0035" "titulo" => "Comment" ] 7 => array:2 [ "identificador" => "sec0040" "titulo" => "Conflicts of Interest" ] 8 => array:1 [ "titulo" => "References" ] ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "NotaPie" => array:1 [ 0 => array:2 [ "etiqueta" => "☆" "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Please cite this article as: Maldonado Seral C, Gómez de Castro C, Vivanco Allende B. Pápulas eritematosas en dorso de mano. Actas Dermosifiliogr. 2019;110:e1–e2.</p>" ] ] "multimedia" => array:3 [ 0 => array:6 [ "identificador" => "fig0005" "etiqueta" => "Figure 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 300 "Ancho" => 169 "Tamanyo" => 10090 ] ] ] 1 => array:7 [ "identificador" => "fig0010" "etiqueta" => "Figure 2" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr2.jpeg" "Alto" => 350 "Ancho" => 233 "Tamanyo" => 37586 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">A, Hematoxylin-eosin, magnification ×<span class="elsevierStyleHsp" style=""></span>10. 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Lobo" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.ad.2010.08.008" "Revista" => array:6 [ "tituloSerie" => "Actas Dermosifiliogr" "fecha" => "2011" "volumen" => "102" "paginaInicial" => "231" "paginaFinal" => "233" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/21382607" "web" => "Medline" ] ] ] ] ] ] ] ] 1 => array:3 [ "identificador" => "bib0040" "etiqueta" => "2" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Multinucleate cell angiohistiocytoma: A new entity" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "N. Smith" 1 => "E. Wilson-Jones" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:4 [ "tituloSerie" => "Br J Dermatol" "fecha" => "1985" "volumen" => "113" "paginaInicial" => "15" ] ] ] ] ] ] 2 => array:3 [ "identificador" => "bib0045" "etiqueta" => "3" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Multinucleate cell angiohistiocytoma: Clinicopathological correlation of 142 cases with insights into etiology and pathogenesis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "J.W. Frew" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1097/DAD.0000000000000075" "Revista" => array:6 [ "tituloSerie" => "Am J Dermatopathol" "fecha" => "2015" "volumen" => "37" "paginaInicial" => "222" "paginaFinal" => "228" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/25140659" "web" => "Medline" ] ] ] ] ] ] ] ] 3 => array:3 [ "identificador" => "bib0050" "etiqueta" => "4" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Multinucleate cell angiohistiocytoma: A fibrohistiocytic proliferation with increased mast cell numbers and vascular hyperplasia" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "L. Puig" 1 => "M.T. Fernández-Figueras" 2 => "I. Bielsa" 3 => "B. Lloveras" 4 => "A. Alomar" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "J Cutan Pathol" "fecha" => "2002" "volumen" => "29" "paginaInicial" => "232" "paginaFinal" => "237" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12028156" "web" => "Medline" ] ] ] ] ] ] ] ] 4 => array:3 [ "identificador" => "bib0055" "etiqueta" => "5" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Estrogen receptor alpha overexpression in multinucleate cell angiohistiocytoma: New insights into the pathogenesis of a reactive process" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "A.M. Cesinaro" 1 => "L. Roncati" 2 => "A. Maiorana" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1097/DAD.0b013e3181d3ca49" "Revista" => array:6 [ "tituloSerie" => "Am J Dermatopathol" "fecha" => "2010" "volumen" => "32" "paginaInicial" => "655" "paginaFinal" => "659" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/20644465" "web" => "Medline" ] ] ] ] ] ] ] ] 5 => array:3 [ "identificador" => "bib0060" "etiqueta" => "6" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Facial multinucleate cell angiohistiocytoma: Long-term remission with 585<span class="elsevierStyleHsp" style=""></span>nm pulsed dye laser" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "V. Richer" 1 => "H. Lui" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1111/ced.12717" "Revista" => array:6 [ "tituloSerie" => "Clin Exp Dermatol" "fecha" => "2016" "volumen" => "41" "paginaInicial" => "312" "paginaFinal" => "313" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/26269389" "web" => "Medline" ] ] ] ] ] ] ] ] ] ] ] ] ] "idiomaDefecto" => "en" "url" => "/15782190/0000011000000001/v1_201901030631/S1578219018304074/v1_201901030631/en/main.assets" "Apartado" => array:4 [ "identificador" => "76903" "tipo" => "SECCION" "en" => array:2 [ "titulo" => "e-Case for Diagnosis" "idiomaDefecto" => true ] "idiomaDefecto" => "en" ] "PDF" => "https://static.elsevier.es/multimedia/15782190/0000011000000001/v1_201901030631/S1578219018304074/v1_201901030631/en/main.pdf?idApp=UINPBA000044&text.app=https://actasdermo.org/" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1578219018304074?idApp=UINPBA000044" ]
| año/Mes | Html | Total | |
|---|---|---|---|
| 2024 Noviembre | 11 | 10 | 21 |
| 2024 Octubre | 192 | 53 | 245 |
| 2024 Septiembre | 247 | 22 | 269 |
| 2024 Agosto | 226 | 52 | 278 |
| 2024 Julio | 227 | 37 | 264 |
| 2024 Junio | 209 | 37 | 246 |
| 2024 Mayo | 172 | 35 | 207 |
| 2024 Abril | 203 | 48 | 251 |
| 2024 Marzo | 256 | 31 | 287 |
| 2024 Febrero | 188 | 37 | 225 |
| 2024 Enero | 195 | 32 | 227 |
| 2023 Diciembre | 211 | 27 | 238 |
| 2023 Noviembre | 244 | 29 | 273 |
| 2023 Octubre | 227 | 37 | 264 |
| 2023 Septiembre | 170 | 33 | 203 |
| 2023 Agosto | 142 | 15 | 157 |
| 2023 Julio | 163 | 28 | 191 |
| 2023 Junio | 142 | 20 | 162 |
| 2023 Mayo | 137 | 22 | 159 |
| 2023 Abril | 106 | 22 | 128 |
| 2023 Marzo | 89 | 26 | 115 |
| 2023 Febrero | 72 | 40 | 112 |
| 2023 Enero | 62 | 28 | 90 |
| 2022 Diciembre | 72 | 41 | 113 |
| 2022 Noviembre | 58 | 22 | 80 |
| 2022 Octubre | 41 | 22 | 63 |
| 2022 Septiembre | 32 | 32 | 64 |
| 2022 Agosto | 39 | 49 | 88 |
| 2022 Julio | 50 | 49 | 99 |
| 2022 Junio | 36 | 27 | 63 |
| 2022 Mayo | 113 | 37 | 150 |
| 2022 Abril | 122 | 29 | 151 |
| 2022 Marzo | 112 | 63 | 175 |
| 2022 Febrero | 83 | 31 | 114 |
| 2022 Enero | 101 | 47 | 148 |
| 2021 Diciembre | 80 | 60 | 140 |
| 2021 Noviembre | 80 | 42 | 122 |
| 2021 Octubre | 75 | 56 | 131 |
| 2021 Septiembre | 65 | 40 | 105 |
| 2021 Agosto | 51 | 34 | 85 |
| 2021 Julio | 61 | 26 | 87 |
| 2021 Junio | 54 | 29 | 83 |
| 2021 Mayo | 115 | 45 | 160 |
| 2021 Abril | 148 | 119 | 267 |
| 2021 Marzo | 93 | 35 | 128 |
| 2021 Febrero | 72 | 38 | 110 |
| 2021 Enero | 46 | 37 | 83 |
| 2020 Diciembre | 48 | 37 | 85 |
| 2020 Noviembre | 36 | 38 | 74 |
| 2020 Octubre | 23 | 14 | 37 |
| 2020 Septiembre | 40 | 18 | 58 |
| 2020 Agosto | 33 | 26 | 59 |
| 2020 Julio | 31 | 25 | 56 |
| 2020 Junio | 36 | 25 | 61 |
| 2020 Mayo | 22 | 14 | 36 |
| 2020 Abril | 20 | 9 | 29 |
| 2020 Marzo | 20 | 4 | 24 |
| 2020 Febrero | 1 | 0 | 1 |
| 2019 Mayo | 1 | 0 | 1 |
| 2019 Abril | 1 | 0 | 1 |
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