Case and Research Letters
Inflammation of Actinic Keratosis During Panitumumab Therapy
Inflamación de queratosis actínicas durante el tratamiento con panitumumab
Leído
5090
Vecesse ha leído el artículo
1964
Total PDF
3126
Total HTML
Compartir estadísticas
array:24 [ "pii" => "S1578219018302415" "issn" => "15782190" "doi" => "10.1016/j.adengl.2018.07.005" "estado" => "S300" "fechaPublicacion" => "2018-10-01" "aid" => "1847" "copyright" => "Elsevier España, S.L.U. and AEDV" "copyrightAnyo" => "2017" "documento" => "simple-article" "crossmark" => 1 "subdocumento" => "crp" "cita" => "Actas Dermosifiliogr. 2018;109:749-51" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:2 [ "total" => 4 "formatos" => array:2 [ "HTML" => 2 "PDF" => 2 ] ] "Traduccion" => array:1 [ "es" => array:19 [ "pii" => "S0001731017306038" "issn" => "00017310" "doi" => "10.1016/j.ad.2017.08.015" "estado" => "S300" "fechaPublicacion" => "2018-10-01" "aid" => "1847" "copyright" => "AEDV" "documento" => "simple-article" "crossmark" => 1 "subdocumento" => "crp" "cita" => "Actas Dermosifiliogr. 2018;109:749-51" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:2 [ "total" => 78 "formatos" => array:2 [ "HTML" => 46 "PDF" => 32 ] ] "es" => array:11 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Cartas científico-clínica</span>" "titulo" => "Inflamación de queratosis actínicas durante el tratamiento con panitumumab" "tienePdf" => "es" "tieneTextoCompleto" => "es" "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "749" "paginaFinal" => "751" ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "Inflammation of Actinic Keratosis During Panitumumab Therapy" ] ] "contieneTextoCompleto" => array:1 [ "es" => true ] "contienePdf" => array:1 [ "es" => true ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0015" "etiqueta" => "Figura 3" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr3.jpeg" "Alto" => 760 "Ancho" => 1250 "Tamanyo" => 248864 ] ] "descripcion" => array:1 [ "es" => "<p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Imagen histológica donde se observa una atipia queratinocítica en la capa basal epidérmica e hiperqueratosis en el infundíbulo folicular. En dermis observamos elastosis solar, melanófagos e infiltrado linfocitario sobre todo perifolicular (H&E ×10).</p>" ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "M.M. Escudero-Góngora, L.J. del Pozo-Hernando, O. Corral-Magaña, E. Antón" "autores" => array:4 [ 0 => array:2 [ "nombre" => "M.M." "apellidos" => "Escudero-Góngora" ] 1 => array:2 [ "nombre" => "L.J." "apellidos" => "del Pozo-Hernando" ] 2 => array:2 [ "nombre" => "O." "apellidos" => "Corral-Magaña" ] 3 => array:2 [ "nombre" => "E." "apellidos" => "Antón" ] ] ] ] ] "idiomaDefecto" => "es" "Traduccion" => array:1 [ "en" => array:9 [ "pii" => "S1578219018302415" "doi" => "10.1016/j.adengl.2018.07.005" "estado" => "S300" "subdocumento" => "" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1578219018302415?idApp=UINPBA000044" ] ] "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0001731017306038?idApp=UINPBA000044" "url" => "/00017310/0000010900000008/v1_201810020614/S0001731017306038/v1_201810020614/es/main.assets" ] ] "itemSiguiente" => array:19 [ "pii" => "S1578219018302300" "issn" => "15782190" "doi" => "10.1016/j.adengl.2018.06.018" "estado" => "S300" "fechaPublicacion" => "2018-10-01" "aid" => "1893" "copyright" => "Elsevier España, S.L.U. and AEDV" "documento" => "simple-article" "crossmark" => 1 "subdocumento" => "crp" "cita" => "Actas Dermosifiliogr. 2018;109:751-2" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:2 [ "total" => 1 "HTML" => 1 ] "en" => array:11 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Case and Research Letters</span>" "titulo" => "Alopecia Areata and Palmoplantar Pustulosis: Report of 4 Cases" "tienePdf" => "en" "tieneTextoCompleto" => "en" "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "751" "paginaFinal" => "752" ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Alopecia areata y pustulosis palmoplantar: informe de 4 casos" ] ] "contieneTextoCompleto" => array:1 [ "en" => true ] "contienePdf" => array:1 [ "en" => true ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0005" "etiqueta" => "Figure 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 992 "Ancho" => 1300 "Tamanyo" => 181625 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Representative figures are shown. Case 2 presented with plantar lesion of PPP (a) and alopecia areata (b).</p>" ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "T. Hiraiwa, T. Yamamoto" "autores" => array:2 [ 0 => array:2 [ "nombre" => "T." "apellidos" => "Hiraiwa" ] 1 => array:2 [ "nombre" => "T." "apellidos" => "Yamamoto" ] ] ] ] ] "idiomaDefecto" => "en" "Traduccion" => array:1 [ "es" => array:9 [ "pii" => "S0001731018300358" "doi" => "10.1016/j.ad.2017.09.022" "estado" => "S300" "subdocumento" => "" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0001731018300358?idApp=UINPBA000044" ] ] "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1578219018302300?idApp=UINPBA000044" "url" => "/15782190/0000010900000008/v1_201810020631/S1578219018302300/v1_201810020631/en/main.assets" ] "itemAnterior" => array:19 [ "pii" => "S1578219018302609" "issn" => "15782190" "doi" => "10.1016/j.adengl.2017.09.003" "estado" => "S300" "fechaPublicacion" => "2018-10-01" "aid" => "1971" "copyright" => "Elsevier España, S.L.U. and AEDV" "documento" => "article" "crossmark" => 1 "subdocumento" => "sco" "cita" => "Actas Dermosifiliogr. 2018;109:748" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:2 [ "total" => 4 "HTML" => 4 ] "en" => array:11 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Images in Dermatology</span>" "titulo" => "Depression of the Frontal Veins in Frontal Fibrosing Alopecia" "tienePdf" => "en" "tieneTextoCompleto" => "en" "paginas" => array:1 [ 0 => array:1 [ "paginaInicial" => "748" ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Depresión de las venas frontales en la alopecia frontal fibrosante" ] ] "contieneTextoCompleto" => array:1 [ "en" => true ] "contienePdf" => array:1 [ "en" => true ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:6 [ "identificador" => "fig0005" "etiqueta" => "Figure 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 1134 "Ancho" => 850 "Tamanyo" => 135773 ] ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "E. González-Guerra" "autores" => array:1 [ 0 => array:2 [ "nombre" => "E." "apellidos" => "González-Guerra" ] ] ] ] ] "idiomaDefecto" => "en" "Traduccion" => array:1 [ "es" => array:9 [ "pii" => "S0001731018302096" "doi" => "10.1016/j.ad.2017.09.028" "estado" => "S300" "subdocumento" => "" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0001731018302096?idApp=UINPBA000044" ] ] "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1578219018302609?idApp=UINPBA000044" "url" => "/15782190/0000010900000008/v1_201810020631/S1578219018302609/v1_201810020631/en/main.assets" ] "en" => array:16 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Case and Research Letters</span>" "titulo" => "Inflammation of Actinic Keratosis During Panitumumab Therapy" "tieneTextoCompleto" => true "saludo" => "<span class="elsevierStyleItalic">To the Editor:</span>" "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "749" "paginaFinal" => "751" ] ] "autores" => array:1 [ 0 => array:4 [ "autoresLista" => "M.M. Escudero-Góngora, L.J. del Pozo-Hernando, O. Corral-Magaña, E. Antón" "autores" => array:4 [ 0 => array:4 [ "nombre" => "M.M." "apellidos" => "Escudero-Góngora" "email" => array:1 [ 0 => "mmarescudero88@gmail.com" ] "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">*</span>" "identificador" => "cor0005" ] ] ] 1 => array:3 [ "nombre" => "L.J." "apellidos" => "del Pozo-Hernando" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] ] ] 2 => array:3 [ "nombre" => "O." "apellidos" => "Corral-Magaña" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] ] ] 3 => array:3 [ "nombre" => "E." "apellidos" => "Antón" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] ] ] ] "afiliaciones" => array:2 [ 0 => array:3 [ "entidad" => "Servicio de Dermatología, Hospital Universitario Son Espases, Palma de Mallorca, España" "etiqueta" => "a" "identificador" => "aff0005" ] 1 => array:3 [ "entidad" => "Servicio de Anatomía Patológica, Hospital Universitario Son Espases, Palma de Mallorca, España" "etiqueta" => "b" "identificador" => "aff0010" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "⁎" "correspondencia" => "Corresponding author." ] ] ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Inflamación de queratosis actínicas durante el tratamiento con panitumumab" ] ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0015" "etiqueta" => "Figure 3" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr3.jpeg" "Alto" => 760 "Ancho" => 1250 "Tamanyo" => 248697 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Histological image showing atypical keratinocytes in the basal layer of the epidermis and hyperkeratosis in the follicular infundibulum. Solar elastosis, melanophages, and predominantly perifollicular lymphocytic infiltrate are evident in the dermis (hematoxylin and eosin, original magnification<span class="elsevierStyleHsp" style=""></span>×<span class="elsevierStyleHsp" style=""></span>10).</p>" ] ] ] "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">Panitumumab is a monoclonal antibody that inhibits epidermal growth factor (EGF) by binding to its extracellular domain.<a class="elsevierStyleCrossRef" href="#bib0055"><span class="elsevierStyleSup">1</span></a> It is approved for the treatment of metastatic colorectal carcinoma in patients who express EGF receptor and wild-type <span class="elsevierStyleItalic">KRAS</span>. Adverse cutaneous effects can occur in up to 90% of patients.<a class="elsevierStyleCrossRef" href="#bib0055"><span class="elsevierStyleSup">1</span></a> We present a case of panitumumab-associated inflammation of subclinical actinic keratosis, an adverse effect not described in the literature to date.</p><p id="par0010" class="elsevierStylePara elsevierViewall">The patient was an 80-year-old woman who in 2007 had been diagnosed with stage IV <span class="elsevierStyleItalic">KRAS</span> wild-type adenocarcinoma with metastasis in the liver, lung, mediastinum, and peritoneum. After progression during several lines of chemotherapy she began intravenous panitumumab monotherapy every 3 weeks. Two months after beginning panitumumab treatment she attended the dermatology department with erythematous-desquamative lesions on the face that were rough to the touch and in some cases erosive (<a class="elsevierStyleCrossRef" href="#fig0005">Fig. 1</a>). She had no history of skin problems and was taking no other medication. Dermatoscopy of the lesions showed an erythematous pseudoreticulum with a distinctive strawberry pattern (<a class="elsevierStyleCrossRef" href="#fig0010">Fig. 2</a>). Biopsy of one of the lesions revealed the presence of atypical keratinocytes, which were largely confined to the basal layer of the epidermis. Marked solar elastosis, predominantly perifollicular lymphocytic infiltrate, and scattered melanophages were evident in the dermis (<a class="elsevierStyleCrossRef" href="#fig0015">Fig. 3</a>). The patient was diagnosed with grade 1 actinic keratosis with inflammation,<a class="elsevierStyleCrossRefs" href="#bib0060"><span class="elsevierStyleSup">2,3</span></a> for which she was treated for 2 weeks with a topical corticosteroid and antibiotics. She received a total of 8 cycles of panitumumab therapy. Five months later the lesions reappeared, leaving a residual pink macula (<a class="elsevierStyleCrossRef" href="#fig0005">Fig. 1</a>B).</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><elsevierMultimedia ident="fig0010"></elsevierMultimedia><elsevierMultimedia ident="fig0015"></elsevierMultimedia><p id="par0015" class="elsevierStylePara elsevierViewall">Cutaneous effects of panitumumab include alterations of the hair and nails, mucositis, photosensitivity, xerosis, fissures, and papulopustular eruptions, and may necessitate dose reduction.<a class="elsevierStyleCrossRef" href="#bib0070"><span class="elsevierStyleSup">4</span></a></p><p id="par0020" class="elsevierStylePara elsevierViewall">Inflammation of actinic keratosis is common in patients treated with imiquimod, ingenol mebutate, or topical 5-fluorouracil, and its intensity appears to be related to the degree of clinical response.<a class="elsevierStyleCrossRef" href="#bib0075"><span class="elsevierStyleSup">5</span></a> Subclinical actinic keratosis in the field of cancerization is also frequently observed following treatment with these agents,<a class="elsevierStyleCrossRef" href="#bib0075"><span class="elsevierStyleSup">5</span></a> and following systemic monotherapy with a variety of chemotherapeutic agents including fluorouracil, capecitabine, doxorubicin, deoxycoformycin, cisplatin, docetaxel, and fludarabine. Inflammation of actinic keratosis has also been reported in patients treated with combination therapies (dactinomycin, dacarbazine, and vincristine, and doxorubicin, cytarabine, and 6-thioguanine),<a class="elsevierStyleCrossRef" href="#bib0080"><span class="elsevierStyleSup">6</span></a> and with new target therapies, including sorafenib, sunitinib, and erlotinib.<a class="elsevierStyleCrossRefs" href="#bib0085"><span class="elsevierStyleSup">7–9</span></a> However, we have found no reports linking panitumumab therapy to inflammation of actinic keratosis.</p><p id="par0025" class="elsevierStylePara elsevierViewall">The pathogenesis of this reaction remains unclear. Inflammation of actinic keratosis in patients treated with classical chemotherapeutic agents may reflect a direct cytotoxic effect on atypical keratinocytes or radiation recall in the field of cancerization.<a class="elsevierStyleCrossRef" href="#bib0090"><span class="elsevierStyleSup">8</span></a> In the case of sunitinib, an antiangiogenic effect on atypical keratinocytes is suspected.<a class="elsevierStyleCrossRef" href="#bib0085"><span class="elsevierStyleSup">7</span></a></p><p id="par0030" class="elsevierStylePara elsevierViewall">EGF receptor function is dysregulated in actinic keratosis and squamous cell carcinoma.<a class="elsevierStyleCrossRef" href="#bib0100"><span class="elsevierStyleSup">10</span></a> It is therefore possible that panitumumab-induced inhibition of this receptor triggered the inflammation of actinic keratosis in our patient. The preferential accumulation of the drug in the follicular infundibulum could favor hyperkeratinization and secondary inflammation of subclinical actinic keratosis, as previously proposed for erlotinib.<a class="elsevierStyleCrossRef" href="#bib0095"><span class="elsevierStyleSup">9</span></a> It remains unknown whether this cutaneous reaction is associated with a better treatment response, as described for erlotinib.<a class="elsevierStyleCrossRef" href="#bib0095"><span class="elsevierStyleSup">9</span></a></p><p id="par0035" class="elsevierStylePara elsevierViewall">In summary, we present the first described case of panitumumab-associated inflammation of subclinical actinic keratosis. While this adverse effect has been previously described for some classic chemotherapeutic drugs and new target therapies, the underlying mechanism remains unknown.</p><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0005">Conflicts of Interest</span><p id="par0040" class="elsevierStylePara elsevierViewall">The authors declare that they have no conflicts of interest.</p></span></span>" "textoCompletoSecciones" => array:1 [ "secciones" => array:2 [ 0 => array:2 [ "identificador" => "sec0005" "titulo" => "Conflicts of Interest" ] 1 => array:1 [ "titulo" => "References" ] ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "NotaPie" => array:1 [ 0 => array:2 [ "etiqueta" => "☆" "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Please cite this article as: Escudero-Góngora MM, del Pozo-Hernando LJ, Corral-Magaña O, Antón E. Inflamación de queratosis actínicas durante el tratamiento con panitumumab. Actas Dermosifiliogr. 2018;109:749–751.</p>" ] ] "multimedia" => array:3 [ 0 => array:7 [ "identificador" => "fig0005" "etiqueta" => "Figure 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 501 "Ancho" => 1250 "Tamanyo" => 98321 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Erythematous desquamative lesions on the patient's forehead (A) that resolved after 8 cycles of panitumumab therapy (B).</p>" ] ] 1 => array:7 [ "identificador" => "fig0010" "etiqueta" => "Figure 2" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr2.jpeg" "Alto" => 502 "Ancho" => 750 "Tamanyo" => 61551 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Dermatoscopic image of one of the lesions showing erythema, desquamation, and an erythematous pseudoreticulum with a strawberry pattern.</p>" ] ] 2 => array:7 [ "identificador" => "fig0015" "etiqueta" => "Figure 3" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr3.jpeg" "Alto" => 760 "Ancho" => 1250 "Tamanyo" => 248697 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Histological image showing atypical keratinocytes in the basal layer of the epidermis and hyperkeratosis in the follicular infundibulum. Solar elastosis, melanophages, and predominantly perifollicular lymphocytic infiltrate are evident in the dermis (hematoxylin and eosin, original magnification<span class="elsevierStyleHsp" style=""></span>×<span class="elsevierStyleHsp" style=""></span>10).</p>" ] ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0015" "bibliografiaReferencia" => array:10 [ 0 => array:3 [ "identificador" => "bib0055" "etiqueta" => "1" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Clinical signs, pathophysiology and management of skin toxicity during therapy with epidermal growth factor receptor inhibitors" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "S. Segaert" 1 => "E. van Cutsem" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1093/annonc/mdi279" "Revista" => array:6 [ "tituloSerie" => "Ann Oncol" "fecha" => "2005" "volumen" => "16" "paginaInicial" => "1425" "paginaFinal" => "1433" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16012181" "web" => "Medline" ] ] ] ] ] ] ] ] 1 => array:3 [ "identificador" => "bib0060" "etiqueta" => "2" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Histopathology of incipient intraepidermal squamous cell carcinoma (“actinic keratosis”)" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "C.J. Cockerell" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "J Am Acad Dermatol" "fecha" => "2000" "volumen" => "42" "paginaInicial" => "11" "paginaFinal" => "17" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10607351" "web" => "Medline" ] ] ] ] ] ] ] ] 2 => array:3 [ "identificador" => "bib0065" "etiqueta" => "3" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Actinic keratosis: Correlation between clinical and histological classification systems" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "L. Schmitz" 1 => "P. Hakl" 2 => "M. Majores" 3 => "E. Bierhoff" 4 => "E. Stockfleth" 5 => "T. Dirschka" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1111/jdv.13626" "Revista" => array:6 [ "tituloSerie" => "JEADV" "fecha" => "2016" "volumen" => "30" "paginaInicial" => "1303" "paginaFinal" => "1307" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/26955898" "web" => "Medline" ] ] ] ] ] ] ] ] 3 => array:3 [ "identificador" => "bib0070" "etiqueta" => "4" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Cutaneous adverse effects of targeted therapies: Part I: Inhibitors of the cellular membrane" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "J.B. Macdonald" 1 => "B. Macdonald" 2 => "L.E. Golitz" 3 => "P. LoRusso" 4 => "A. Sekulic" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.jaad.2014.07.032" "Revista" => array:6 [ "tituloSerie" => "J Am Acad Dermatol" "fecha" => "2015" "volumen" => "72" "paginaInicial" => "203" "paginaFinal" => "218" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/25592338" "web" => "Medline" ] ] ] ] ] ] ] ] 4 => array:3 [ "identificador" => "bib0075" "etiqueta" => "5" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Spanish adaptation of the European guidelines for the evaluation and treatment of actinic keratosis" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "C. Ferrándiz" 1 => "E. Fonseca-Capdevila" 2 => "A. García-Diez" 3 => "C. Guillén-Barona" 4 => "I. Belinchón-Romero" 5 => "P. Redondo-Bellón" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.adengl.2013.11.004" "Revista" => array:6 [ "tituloSerie" => "Actas Dermosifiliogr" "fecha" => "2014" "volumen" => "105" "paginaInicial" => "378" "paginaFinal" => "393" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/24725552" "web" => "Medline" ] ] ] ] ] ] ] ] 5 => array:3 [ "identificador" => "bib0080" "etiqueta" => "6" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Cutaneous reactions to chemotherapy drugs: The art of consultation" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "K.A. Remlinger" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Arch Dermatol" "fecha" => "2003" "volumen" => "139" "paginaInicial" => "77" "paginaFinal" => "81" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12533171" "web" => "Medline" ] ] ] ] ] ] ] ] 6 => array:3 [ "identificador" => "bib0085" "etiqueta" => "7" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Improvement of actinic keratosis associated with sunitinib therapy for metastatic renal cell carcinoma" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "J.M. Mir-Bonafé" 1 => "J. Cañueeto" 2 => "J. Bravo" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1111/j.1365-4632.2011.05265.x" "Revista" => array:6 [ "tituloSerie" => "Int J Dermatol" "fecha" => "2013" "volumen" => "52" "paginaInicial" => "1445" "paginaFinal" => "1447" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/23432117" "web" => "Medline" ] ] ] ] ] ] ] ] 7 => array:3 [ "identificador" => "bib0090" "etiqueta" => "8" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Inflammation of actinic keratoses subsequent to therapy with sorafenib, a multitargeted tyrosinekinase inhibitor" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "M.E. Lacouture" 1 => "A. Desai" 2 => "K. Soltani" 3 => "V. Petronic-Rosic" 4 => "A.E. Laumann" 5 => "M.J. Ratain" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1111/j.1365-2230.2006.02223.x" "Revista" => array:6 [ "tituloSerie" => "Clin Exp Dermatol" "fecha" => "2006" "volumen" => "31" "paginaInicial" => "783" "paginaFinal" => "785" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16824050" "web" => "Medline" ] ] ] ] ] ] ] ] 8 => array:3 [ "identificador" => "bib0095" "etiqueta" => "9" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Erlotinib-responsive actinic keratoses" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "J.F. Hermanns" 1 => "G.E. Piérard" 2 => "P. Quatresooz" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Oncol Rep" "fecha" => "2007" "volumen" => "18" "paginaInicial" => "581" "paginaFinal" => "584" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17671704" "web" => "Medline" ] ] ] ] ] ] ] ] 9 => array:3 [ "identificador" => "bib0100" "etiqueta" => "10" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Dysregulation of epidermal growth factor receptor in actinic keratosis and squamous cell carcinoma" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "S.R. Joseph" 1 => "L. Endo-Munoz" 2 => "D.C. Gaffney" 3 => "N.A. Saunders" 4 => "F. Simpson" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1159/000367959" "Revista" => array:6 [ "tituloSerie" => "Curr Probl Dermatol" "fecha" => "2015" "volumen" => "46" "paginaInicial" => "20" "paginaFinal" => "27" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/25561202" "web" => "Medline" ] ] ] ] ] ] ] ] ] ] ] ] ] "idiomaDefecto" => "en" "url" => "/15782190/0000010900000008/v1_201810020631/S1578219018302415/v1_201810020631/en/main.assets" "Apartado" => array:4 [ "identificador" => "6157" "tipo" => "SECCION" "en" => array:2 [ "titulo" => "Case and Research Letters" "idiomaDefecto" => true ] "idiomaDefecto" => "en" ] "PDF" => "https://static.elsevier.es/multimedia/15782190/0000010900000008/v1_201810020631/S1578219018302415/v1_201810020631/en/main.pdf?idApp=UINPBA000044&text.app=https://actasdermo.org/" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1578219018302415?idApp=UINPBA000044" ]
| año/Mes | Html | Total | |
|---|---|---|---|
| 2024 Noviembre | 6 | 7 | 13 |
| 2024 Octubre | 60 | 49 | 109 |
| 2024 Septiembre | 77 | 27 | 104 |
| 2024 Agosto | 101 | 58 | 159 |
| 2024 Julio | 89 | 36 | 125 |
| 2024 Junio | 109 | 47 | 156 |
| 2024 Mayo | 81 | 49 | 130 |
| 2024 Abril | 70 | 17 | 87 |
| 2024 Marzo | 84 | 26 | 110 |
| 2024 Febrero | 64 | 33 | 97 |
| 2024 Enero | 62 | 33 | 95 |
| 2023 Diciembre | 63 | 18 | 81 |
| 2023 Noviembre | 83 | 27 | 110 |
| 2023 Octubre | 93 | 27 | 120 |
| 2023 Septiembre | 87 | 29 | 116 |
| 2023 Agosto | 51 | 21 | 72 |
| 2023 Julio | 99 | 43 | 142 |
| 2023 Junio | 84 | 29 | 113 |
| 2023 Mayo | 53 | 31 | 84 |
| 2023 Abril | 38 | 23 | 61 |
| 2023 Marzo | 46 | 33 | 79 |
| 2023 Febrero | 54 | 27 | 81 |
| 2023 Enero | 52 | 33 | 85 |
| 2022 Diciembre | 47 | 45 | 92 |
| 2022 Noviembre | 36 | 25 | 61 |
| 2022 Octubre | 67 | 23 | 90 |
| 2022 Septiembre | 58 | 51 | 109 |
| 2022 Agosto | 65 | 34 | 99 |
| 2022 Julio | 55 | 43 | 98 |
| 2022 Junio | 20 | 24 | 44 |
| 2022 Mayo | 35 | 62 | 97 |
| 2022 Abril | 52 | 27 | 79 |
| 2022 Marzo | 46 | 49 | 95 |
| 2022 Febrero | 43 | 31 | 74 |
| 2022 Enero | 65 | 39 | 104 |
| 2021 Diciembre | 56 | 35 | 91 |
| 2021 Noviembre | 73 | 51 | 124 |
| 2021 Octubre | 54 | 56 | 110 |
| 2021 Septiembre | 43 | 45 | 88 |
| 2021 Agosto | 54 | 35 | 89 |
| 2021 Julio | 47 | 41 | 88 |
| 2021 Junio | 36 | 30 | 66 |
| 2021 Mayo | 42 | 41 | 83 |
| 2021 Abril | 88 | 72 | 160 |
| 2021 Marzo | 71 | 36 | 107 |
| 2021 Febrero | 64 | 38 | 102 |
| 2021 Enero | 44 | 36 | 80 |
| 2020 Diciembre | 49 | 43 | 92 |
| 2020 Noviembre | 34 | 42 | 76 |
| 2020 Octubre | 17 | 29 | 46 |
| 2020 Septiembre | 31 | 24 | 55 |
| 2020 Agosto | 22 | 32 | 54 |
| 2020 Julio | 21 | 26 | 47 |
| 2020 Junio | 31 | 40 | 71 |
| 2020 Mayo | 18 | 12 | 30 |
| 2020 Abril | 13 | 11 | 24 |
| 2020 Marzo | 20 | 11 | 31 |
| 2020 Febrero | 1 | 0 | 1 |
| 2020 Enero | 1 | 0 | 1 |
| 2018 Diciembre | 1 | 2 | 3 |
Mostrar todo
