Case and Research Letters
Enfermedad de Rosai-Dorfman cutánea: una nueva presentación clínica
Cutaneous Rosai-Dorfman Disease: A Novel Clinical Presentation
Leído
4969
Vecesse ha leído el artículo
2051
Total PDF
2918
Total HTML
Compartir estadísticas
array:24 [ "pii" => "S1578219018301872" "issn" => "15782190" "doi" => "10.1016/j.adengl.2018.05.027" "estado" => "S300" "fechaPublicacion" => "2018-09-01" "aid" => "1843" "copyright" => "Elsevier España, S.L.U. and AEDV" "copyrightAnyo" => "2017" "documento" => "simple-article" "crossmark" => 1 "subdocumento" => "crp" "cita" => "Actas Dermosifiliogr. 2018;109:655-7" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:2 [ "total" => 1 "HTML" => 1 ] "Traduccion" => array:1 [ "es" => array:19 [ "pii" => "S0001731017305999" "issn" => "00017310" "doi" => "10.1016/j.ad.2017.06.023" "estado" => "S300" "fechaPublicacion" => "2018-09-01" "aid" => "1843" "copyright" => "AEDV" "documento" => "simple-article" "crossmark" => 1 "subdocumento" => "crp" "cita" => "Actas Dermosifiliogr. 2018;109:655-7" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:2 [ "total" => 282 "formatos" => array:2 [ "HTML" => 223 "PDF" => 59 ] ] "es" => array:11 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Carta científico-clínica</span>" "titulo" => "Enfermedad de Rosai-Dorfman cutánea: una nueva presentación clínica" "tienePdf" => "es" "tieneTextoCompleto" => "es" "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "655" "paginaFinal" => "657" ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "Cutaneous Rosai-Dorfman Disease: A Novel Clinical Presentation" ] ] "contieneTextoCompleto" => array:1 [ "es" => true ] "contienePdf" => array:1 [ "es" => true ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0010" "etiqueta" => "Figura 2" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr2.jpeg" "Alto" => 675 "Ancho" => 900 "Tamanyo" => 66742 ] ] "descripcion" => array:1 [ "es" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Se observa en tronco, la presencia de pápulas y pequeños nódulos no foliculares, difusos y diseminados de colores vivos, algunos de los cuales con indentaciones centrales.</p>" ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "J.M. Conde, A.Y. Kim, R. de Miguel, C.H. Nousari" "autores" => array:4 [ 0 => array:2 [ "nombre" => "J.M." "apellidos" => "Conde" ] 1 => array:2 [ "nombre" => "A.Y." "apellidos" => "Kim" ] 2 => array:2 [ "nombre" => "R." "apellidos" => "de Miguel" ] 3 => array:2 [ "nombre" => "C.H." "apellidos" => "Nousari" ] ] ] ] ] "idiomaDefecto" => "es" "Traduccion" => array:1 [ "en" => array:9 [ "pii" => "S1578219018301872" "doi" => "10.1016/j.adengl.2018.05.027" "estado" => "S300" "subdocumento" => "" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1578219018301872?idApp=UINPBA000044" ] ] "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0001731017305999?idApp=UINPBA000044" "url" => "/00017310/0000010900000007/v1_201809020415/S0001731017305999/v1_201809020415/es/main.assets" ] ] "itemSiguiente" => array:19 [ "pii" => "S1578219018301884" "issn" => "15782190" "doi" => "10.1016/j.adengl.2018.05.028" "estado" => "S300" "fechaPublicacion" => "2018-09-01" "aid" => "1844" "copyright" => "Elsevier España, S.L.U. and AEDV" "documento" => "simple-article" "crossmark" => 1 "subdocumento" => "crp" "cita" => "Actas Dermosifiliogr. 2018;109:657-9" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:2 [ "total" => 1 "PDF" => 1 ] "en" => array:11 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Case and Research Letters</span>" "titulo" => "Kikuchi-Fujimoto Disease with Scalp Involvement" "tienePdf" => "en" "tieneTextoCompleto" => "en" "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "657" "paginaFinal" => "659" ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Enfermedad de Kikuchi-Fujimoto con compromiso de cuero cabelludo" ] ] "contieneTextoCompleto" => array:1 [ "en" => true ] "contienePdf" => array:1 [ "en" => true ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0005" "etiqueta" => "Figure 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 1303 "Ancho" => 1733 "Tamanyo" => 508813 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">a) The 3-cm-diameter erythematous plaque on the scalp. b) Haematoxylin and eosin staining showed mild vacuolar change in epidermal basal cells as well as perifollicular lymphohistiocytic infiltration and caryorrhexis in the reticular dermis (40x). c) The perifollicular lymphohistiocytic infiltration in haematoxylin and eosin staining (200x). d) Immunochemical analysis revealed that the lymphoid infiltrate was predominantly CD3+, with CD8 positive cells predominating over CD4.</p>" ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "A. Combalia, X. Fustà-Novell, A. García-Herrera, J. Ferrando" "autores" => array:4 [ 0 => array:2 [ "nombre" => "A." "apellidos" => "Combalia" ] 1 => array:2 [ "nombre" => "X." "apellidos" => "Fustà-Novell" ] 2 => array:2 [ "nombre" => "A." "apellidos" => "García-Herrera" ] 3 => array:2 [ "nombre" => "J." "apellidos" => "Ferrando" ] ] ] ] ] "idiomaDefecto" => "en" "Traduccion" => array:1 [ "es" => array:9 [ "pii" => "S0001731017306002" "doi" => "10.1016/j.ad.2017.09.016" "estado" => "S300" "subdocumento" => "" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0001731017306002?idApp=UINPBA000044" ] ] "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1578219018301884?idApp=UINPBA000044" "url" => "/15782190/0000010900000007/v1_201809020417/S1578219018301884/v1_201809020417/en/main.assets" ] "itemAnterior" => array:19 [ "pii" => "S1578219018301860" "issn" => "15782190" "doi" => "10.1016/j.adengl.2018.05.026" "estado" => "S300" "fechaPublicacion" => "2018-09-01" "aid" => "1842" "copyright" => "Elsevier España, S.L.U. and AEDV" "documento" => "simple-article" "crossmark" => 1 "subdocumento" => "crp" "cita" => "Actas Dermosifiliogr. 2018;109:653-5" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:2 [ "total" => 11 "formatos" => array:2 [ "HTML" => 9 "PDF" => 2 ] ] "en" => array:11 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Case and Research Letters</span>" "titulo" => "Agminated Dermal Melanocytosis in the Territory of Ota's Nevus" "tienePdf" => "en" "tieneTextoCompleto" => "en" "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "653" "paginaFinal" => "655" ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Melanocitosis dérmica agminada en el territorio del nevus de Ota" ] ] "contieneTextoCompleto" => array:1 [ "en" => true ] "contienePdf" => array:1 [ "en" => true ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0005" "etiqueta" => "Figure 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 2241 "Ancho" => 2500 "Tamanyo" => 539289 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">a) Clinical aspect of pigmented lesion b) Dermoscopic features c) RCM in the top left corner: spinous-granular layer of epidermis. In the top right corner: dermo-epidermal junction and upper dermis. In the bottom left corner: upper dermis. In the bottom right corner. Reticular dermis d) OTC images.</p>" ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "L. Diluvio, M. Mazzeo, L. Bianchi, E. Campione" "autores" => array:4 [ 0 => array:2 [ "nombre" => "L." "apellidos" => "Diluvio" ] 1 => array:2 [ "nombre" => "M." "apellidos" => "Mazzeo" ] 2 => array:2 [ "nombre" => "L." "apellidos" => "Bianchi" ] 3 => array:2 [ "nombre" => "E." "apellidos" => "Campione" ] ] ] ] ] "idiomaDefecto" => "en" "Traduccion" => array:1 [ "es" => array:9 [ "pii" => "S0001731017305987" "doi" => "10.1016/j.ad.2017.07.022" "estado" => "S300" "subdocumento" => "" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0001731017305987?idApp=UINPBA000044" ] ] "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1578219018301860?idApp=UINPBA000044" "url" => "/15782190/0000010900000007/v1_201809020417/S1578219018301860/v1_201809020417/en/main.assets" ] "en" => array:16 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Case and Research Letters</span>" "titulo" => "Enfermedad de Rosai-Dorfman cutánea: una nueva presentación clínica" "tieneTextoCompleto" => true "saludo" => "<span class="elsevierStyleItalic">To the Editor:</span>" "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "655" "paginaFinal" => "657" ] ] "autores" => array:1 [ 0 => array:4 [ "autoresLista" => "J.M. Conde, A.Y. Kim, R. de Miguel, C.H. Nousari" "autores" => array:4 [ 0 => array:4 [ "nombre" => "J.M." "apellidos" => "Conde" "email" => array:1 [ 0 => "docmoscoso@gmail.com" ] "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">*</span>" "identificador" => "cor0005" ] ] ] 1 => array:3 [ "nombre" => "A.Y." "apellidos" => "Kim" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] ] ] 2 => array:3 [ "nombre" => "R." "apellidos" => "de Miguel" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">c</span>" "identificador" => "aff0015" ] ] ] 3 => array:3 [ "nombre" => "C.H." "apellidos" => "Nousari" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] ] ] ] "afiliaciones" => array:3 [ 0 => array:3 [ "entidad" => "Dermatology, Broward Health Medical Center/Nova Southeastern University College of Osteopathic Medicine, Fort Lauderdale, FL, EE.UU." "etiqueta" => "a" "identificador" => "aff0005" ] 1 => array:3 [ "entidad" => "Nova Southeastern University College of Osteopathic Medicine, Fort Lauderdale, FL, EE.UU." "etiqueta" => "b" "identificador" => "aff0010" ] 2 => array:3 [ "entidad" => "Celimar Central Clinic, West Bay, Islas Caimán" "etiqueta" => "c" "identificador" => "aff0015" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "⁎" "correspondencia" => "Corresponding author." ] ] ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Cutaneous Rosai-Dorfman Disease: A Novel Clinical Presentation" ] ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0015" "etiqueta" => "Figure 3" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr3.jpeg" "Alto" => 678 "Ancho" => 900 "Tamanyo" => 167588 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Histopathological features. Dense nodular dermal mononuclear cell rich infiltrate showing a significant number of plasma cells and numerous scattered S100 positive multinucleated histiocytes with marked emperipolesis and inconspicuous eosinophils.</p>" ] ] ] "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">A 21-year-old woman presented with a 3-month history of a diffuse asymptomatic eruption on her face and trunk. She denied fever or any other constitutional symptoms and her review of symptoms was non-contributory. She denied any pertinent past medical or family history. Her only medication included norgestimate/ethinyl estradiol which she had been taking for several years. Physical examination revealed diffuse scattered non-follicular based flesh-colored papules and small nodules. Many lesions demonstrated a central indentation resembling molluscum contagiosum (see <a class="elsevierStyleCrossRefs" href="#fig0005">Figures 1 & 2</a>). She did not have any cervical, axillary, or inguinal lymphadenopathy. Mucous membrane examination was unremarkable and lacrimal glands did not appear enlarged. Routine histologic examination of her right neck lesion revealed a dense nodular dermal mononuclear cell rich infiltrate showing a significant number of plasma cells and numerous scattered S100 positive multinucleated histiocytes with marked emperipolesis and inconspicuous eosinophils (see <a class="elsevierStyleCrossRef" href="#fig0015">Figure 3</a>). Complete blood count with differential, erythrocyte sedimentation rate, lactate dehydrogenase, liver transaminases, alkaline phosphatase, bilirubin, and creatinine were negative or within normal limits. Chest and abdominal magnetic resonance imaging were normal. She was treated with a 60<span class="elsevierStyleHsp" style=""></span>mg oral prednisone taper over six months which resulted in complete resolution of her skin lesions. Follow up at 10 months from onset of disease demonstrated complete remission.</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><elsevierMultimedia ident="fig0010"></elsevierMultimedia><elsevierMultimedia ident="fig0015"></elsevierMultimedia><p id="par0010" class="elsevierStylePara elsevierViewall">Rosai-Dorfman Disease (RDD) is a relatively rare histiocytic proliferation disorder that was first described in 1969.<a class="elsevierStyleCrossRef" href="#bib0055"><span class="elsevierStyleSup">1</span></a> Though RDD classically presents with bilateral massive lymphadenopathy and systemic symptoms, it typically has a benign clinical course and favorable prognosis. In RDD, 43% of patients have involvement of other extranodal sites with skin being the most common site.<a class="elsevierStyleCrossRef" href="#bib0060"><span class="elsevierStyleSup">2</span></a> Though skin comprises 10% of extranodal sites involved, approximately 3% are solely cutaneous Rosai-Dorfman Disease (CRDD) without any nodal or other extranodal sites.<a class="elsevierStyleCrossRef" href="#bib0065"><span class="elsevierStyleSup">3</span></a> While incidence is reportedly low, CRDD is more prevalent in middle-aged White and Asian women.<a class="elsevierStyleCrossRef" href="#bib0060"><span class="elsevierStyleSup">2</span></a> The etiology of RDD is unclear although immunologic,<a class="elsevierStyleCrossRef" href="#bib0070"><span class="elsevierStyleSup">4</span></a> viral, and genetic causes including SLC29A3 mutations have been hypothesized.<a class="elsevierStyleCrossRef" href="#bib0075"><span class="elsevierStyleSup">5</span></a></p><p id="par0015" class="elsevierStylePara elsevierViewall">The classic presentation of CRDD is a relatively asymptomatic self-involuting nodulo-plaque with surrounding satellite papules.<a class="elsevierStyleCrossRef" href="#bib0065"><span class="elsevierStyleSup">3</span></a> However, an evolving wide spectrum of clinical morphologic presentations have been reported. The most common site involved is the face, followed by thigh, and trunk. Recurrence has been reported to occur within 1 to 3.5 years.<a class="elsevierStyleCrossRef" href="#bib0080"><span class="elsevierStyleSup">6</span></a> To the best of our knowledge, this will be the first description of RDD mimicking molluscum contagiosum.</p><p id="par0020" class="elsevierStylePara elsevierViewall">The pathognomonic histologic finding of RDD is emperipolesis of intact lymphocytes by S100 and CD68 positive as well as CD1a and langerin negative pale histiocytes characterized also by vesicular nuclei and small nucleoli. Of note, emperipolesis entitles the presence of engulfing of intact hematologic cells, as opposed to hemophagiocytosis which degrades engulfed cells, by histiocytes or megakaryocytes. The so called “Rosai-Dorfman cell” is a type of histiocyte characterized by empiropolesis of only haloed lymphocytes.</p><p id="par0025" class="elsevierStylePara elsevierViewall">These characteristic histiocytes can be abundant or inconspicuously scattered amidst other inflammatory cells.<a class="elsevierStyleCrossRef" href="#bib0085"><span class="elsevierStyleSup">7</span></a> Plasma cells are virtually present in all lesions of CRDD. Polymorphonuclear cells, namely eosinophils, are frequently found in skin lesions. Increased vascularity with plump endothelium, with or without fibrosis, are not uncommonly identified namely in long standing lesions.</p><p id="par0030" class="elsevierStylePara elsevierViewall">Emperipolesis in cutaneous disorders has been traditionally related to RDD until recent descriptions of other disorders related to the so-called H syndrome.<a class="elsevierStyleCrossRef" href="#bib0090"><span class="elsevierStyleSup">8</span></a> This disorder is characterized by hyperpigmentation, hypertrichosis, hearing loss, heart anomalies, hepatosplenomegaly, hypogonadism, and hallux valgus<a class="elsevierStyleCrossRef" href="#bib0095"><span class="elsevierStyleSup">9</span></a> and is caused by a mutation in the SLC29A3 gene. Many authors believe that syndromes associated with mutations in SLC29A3 including familial RDD and pigmented hypertrichosis with insulin-dependent diabetes,<a class="elsevierStyleCrossRef" href="#bib0075"><span class="elsevierStyleSup">5</span></a> in addition to H syndrome, fall into the same spectrum of RDD.</p><p id="par0035" class="elsevierStylePara elsevierViewall">Recognition of the pleomorphic genetic and phenotypic presentations of SCL29A3-related diseases is important for diagnosis and for consideration in the histopathologic differential diagnosis of emperipolesis. In addition to SCL29A3-related diseases, IgG4-related diseases have also been shown to have some overlap with RDD as a subset of RDD has been found to contain increased numbers of IgG4-positive plasma cells.<a class="elsevierStyleCrossRef" href="#bib0070"><span class="elsevierStyleSup">4</span></a> However, much controversy remains regarding this.</p><p id="par0040" class="elsevierStylePara elsevierViewall">Currently there is no standard guideline for the management of CRDD. The clinical course of CRDD is usually benign and self-limited. Spontaneous resolution varies and ranges from months to several years.<a class="elsevierStyleCrossRef" href="#bib0060"><span class="elsevierStyleSup">2</span></a> A wide spectrum of therapeutic interventions including surgical excision, cryotherapy, radiotherapy, lesional and systemic corticosteroids, thalidomide, methotrexate, and even chemotherapy<a class="elsevierStyleCrossRef" href="#bib0100"><span class="elsevierStyleSup">10</span></a> have also been reported to be successful for resistant and/or recurrent lesions.</p><p id="par0045" class="elsevierStylePara elsevierViewall">In summary, we first present a case of CRDD with a peculiar eruption resembling molluscum contagiousum thus expanding the spectrum of the cutaneous clinical presentation of the disease and making CRDD another dermatologic masquerader. The nonspecific clinical presentation along with the not infrequently inconspicuous finding of Rosai-Dorfman cells in skin samples and furthermore the typical spontaneous resolution may represent clinico-pathologic characteristics that lead to the tangible possibility of CRDD being underreported.</p><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0005">Conflicts of Interest</span><p id="par0050" class="elsevierStylePara elsevierViewall">The authors declare that they have no conflicts of interest.</p></span></span>" "textoCompletoSecciones" => array:1 [ "secciones" => array:2 [ 0 => array:2 [ "identificador" => "sec0005" "titulo" => "Conflicts of Interest" ] 1 => array:1 [ "titulo" => "Références" ] ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "NotaPie" => array:1 [ 0 => array:2 [ "etiqueta" => "☆" "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Please cite this article as: Conde JM, Kim AY, de Miguel R, Nousari CH. Enfermedad de Rosai-Dorfman cutánea: una nueva presentación clínica. Actas Dermosifiliogr. 2018;109:655–657.</p>" ] ] "multimedia" => array:3 [ 0 => array:7 [ "identificador" => "fig0005" "etiqueta" => "Figure 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 1200 "Ancho" => 900 "Tamanyo" => 110225 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Diffuse scattered non-follicular based flesh-colored papules and small nodules, some with central indentations, were seen on the face and the trunk.</p>" ] ] 1 => array:7 [ "identificador" => "fig0010" "etiqueta" => "Figure 2" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr2.jpeg" "Alto" => 675 "Ancho" => 900 "Tamanyo" => 66742 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Diffuse scattered non-follicular based flesh-colored papules and small nodules, some with central indentations, were seen on the face and the trunk.</p>" ] ] 2 => array:7 [ "identificador" => "fig0015" "etiqueta" => "Figure 3" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr3.jpeg" "Alto" => 678 "Ancho" => 900 "Tamanyo" => 167588 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Histopathological features. Dense nodular dermal mononuclear cell rich infiltrate showing a significant number of plasma cells and numerous scattered S100 positive multinucleated histiocytes with marked emperipolesis and inconspicuous eosinophils.</p>" ] ] ] "bibliografia" => array:2 [ "titulo" => "Références" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0015" "bibliografiaReferencia" => array:10 [ 0 => array:3 [ "identificador" => "bib0055" "etiqueta" => "1" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Sinus histiocytosis with massive lymphadenopathy: A newly recognized benign clinicopathological entity" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "J. Rosai" 1 => "R.F. Dorfman" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Arch Pathol" "fecha" => "1969" "volumen" => "87" "paginaInicial" => "63" "paginaFinal" => "70" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/5782438" "web" => "Medline" ] ] ] ] ] ] ] ] 1 => array:3 [ "identificador" => "bib0060" "etiqueta" => "2" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Cutaneous Rosai-Dorfman disease is a distinct clinical entity" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:7 [ 0 => "T. Brenn" 1 => "E. Calonje" 2 => "S. Granter" 3 => "N. Leonard" 4 => "W. Grayson" 5 => "C.D.M. Fletcher" 6 => "P.H. McKee" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Am J Dermatopathol" "fecha" => "2002" "volumen" => "24" "paginaInicial" => "385" "paginaFinal" => "391" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12357197" "web" => "Medline" ] ] ] ] ] ] ] ] 2 => array:3 [ "identificador" => "bib0065" "etiqueta" => "3" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Clinical and histopathologic spectrum of cutaneous Rosai-Dorfman disease in Taiwan" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "C.I. Lu" 1 => "T.T. Kuo" 2 => "W.R. Wong" 3 => "H.S. Hong" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.jaad.2004.04.030" "Revista" => array:6 [ "tituloSerie" => "J Am Acad Dermatol" "fecha" => "2004" "volumen" => "51" "paginaInicial" => "931" "paginaFinal" => "939" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15583585" "web" => "Medline" ] ] ] ] ] ] ] ] 3 => array:3 [ "identificador" => "bib0070" "etiqueta" => "4" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "A subset of Rosai-Dorfman disease exhibits features of IgG4-related disease" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "X. Zhang" 1 => "E. Hyjek" 2 => "J. Vardiman" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1309/AJCPARC3YQ0KLIOA" "Revista" => array:6 [ "tituloSerie" => "Am J Clin Pathol" "fecha" => "2013" "volumen" => "139" "paginaInicial" => "622" "paginaFinal" => "632" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/23596114" "web" => "Medline" ] ] ] ] ] ] ] ] 4 => array:3 [ "identificador" => "bib0075" "etiqueta" => "5" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Mutations in SLC29A3, encoding an equilibrative nucleoside transporter ENT3, cause a familial histiocytosis syndrome (Faisalaba histiocytosis) and familial Rosai-Dorfman disease" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "N.V. Morgan" 1 => "M.R. Morris" 2 => "H. Vangul" 3 => "D. Gleeson" 4 => "A. Straatman-Iwanowska" 5 => "N. Davies" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1371/journal.pgen.1000833" "Revista" => array:5 [ "tituloSerie" => "PLoS Genet" "fecha" => "2010" "volumen" => "6" "paginaInicial" => "e1000833" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/20140240" "web" => "Medline" ] ] ] ] ] ] ] ] 5 => array:3 [ "identificador" => "bib0080" "etiqueta" => "6" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Successful treatment of refractory cutaneous Rosai-Dorfman disease with vincristine" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "P. Liu" 1 => "P. Wang" 2 => "J. Du" 3 => "J. Zhang" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1111/1346-8138.12694" "Revista" => array:6 [ "tituloSerie" => "J Dermatol" "fecha" => "2015" "volumen" => "42" "paginaInicial" => "97" "paginaFinal" => "98" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/25420547" "web" => "Medline" ] ] ] ] ] ] ] ] 6 => array:3 [ "identificador" => "bib0085" "etiqueta" => "7" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Rosai-Dorfman disease: A case report with nodal and cutaneous involvement and rehe literature" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "Z. Kutlubay" 1 => "O. Bairamov" 2 => "A. Sevim" 3 => "C. Demirkesen" 4 => "M.C. Mat" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1097/DAD.0b013e31829e5564" "Revista" => array:6 [ "tituloSerie" => "Am J Dermatopathol" "fecha" => "2014" "volumen" => "36" "paginaInicial" => "353" "paginaFinal" => "357" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/23863552" "web" => "Medline" ] ] ] ] ] ] ] ] 7 => array:3 [ "identificador" => "bib0090" "etiqueta" => "8" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Emperipolesis: An additional common histopathologic finding in H syndrome and Rosai-Dorfman disease" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "I. Colmenero" 1 => "V. Molho-Pessach" 2 => "A. Torrelo" 3 => "A. Ziotogorski" 4 => "L. Requena" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1097/DAD.0b013e31823b99fc" "Revista" => array:6 [ "tituloSerie" => "Am J Dermatopathol" "fecha" => "2012" "volumen" => "34" "paginaInicial" => "315" "paginaFinal" => "320" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/22356918" "web" => "Medline" ] ] ] ] ] ] ] ] 8 => array:3 [ "identificador" => "bib0095" "etiqueta" => "9" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The H Syndrome Is Caused by Mutations in the Nucleoside Transporter hENT3" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "V. Molho-Pessach" 1 => "I. Lerer" 2 => "D. Abeliovich" 3 => "Z. Agha" 4 => "A.A. Libdeh" 5 => "V. Brohtilova" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Am J Hum Genet" "fecha" => "2008" "volumen" => "86" "paginaInicial" => "529" "paginaFinal" => "534" ] ] ] ] ] ] 9 => array:3 [ "identificador" => "bib0100" "etiqueta" => "10" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Cutaneous Rosai-Dorfman disease: Clinicopathological profiles, spectrum and evolution of 21 lesions in six patients" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "K.H. Wang" 1 => "W.Y. Chen" 2 => "H.N. Liu" 3 => "C.C. Huang" 4 => "W.R. Lee" 5 => "C.H. Hu" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1111/j.1365-2133.2005.06917.x" "Revista" => array:6 [ "tituloSerie" => "Br J Dermatol" "fecha" => "2006" "volumen" => "154" "paginaInicial" => "277" "paginaFinal" => "286" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16433797" "web" => "Medline" ] ] ] ] ] ] ] ] ] ] ] ] ] "idiomaDefecto" => "en" "url" => "/15782190/0000010900000007/v1_201809020417/S1578219018301872/v1_201809020417/en/main.assets" "Apartado" => array:4 [ "identificador" => "6157" "tipo" => "SECCION" "en" => array:2 [ "titulo" => "Case and Research Letters" "idiomaDefecto" => true ] "idiomaDefecto" => "en" ] "PDF" => "https://static.elsevier.es/multimedia/15782190/0000010900000007/v1_201809020417/S1578219018301872/v1_201809020417/en/main.pdf?idApp=UINPBA000044&text.app=https://actasdermo.org/" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1578219018301872?idApp=UINPBA000044" ]
| año/Mes | Html | Total | |
|---|---|---|---|
| 2024 Noviembre | 6 | 9 | 15 |
| 2024 Octubre | 71 | 44 | 115 |
| 2024 Septiembre | 68 | 29 | 97 |
| 2024 Agosto | 83 | 52 | 135 |
| 2024 Julio | 66 | 31 | 97 |
| 2024 Junio | 78 | 23 | 101 |
| 2024 Mayo | 84 | 34 | 118 |
| 2024 Abril | 88 | 27 | 115 |
| 2024 Marzo | 73 | 22 | 95 |
| 2024 Febrero | 67 | 32 | 99 |
| 2024 Enero | 53 | 25 | 78 |
| 2023 Diciembre | 61 | 15 | 76 |
| 2023 Noviembre | 90 | 34 | 124 |
| 2023 Octubre | 71 | 38 | 109 |
| 2023 Septiembre | 71 | 40 | 111 |
| 2023 Agosto | 60 | 18 | 78 |
| 2023 Julio | 67 | 50 | 117 |
| 2023 Junio | 55 | 30 | 85 |
| 2023 Mayo | 63 | 24 | 87 |
| 2023 Abril | 43 | 23 | 66 |
| 2023 Marzo | 85 | 26 | 111 |
| 2023 Febrero | 57 | 34 | 91 |
| 2023 Enero | 51 | 44 | 95 |
| 2022 Diciembre | 50 | 59 | 109 |
| 2022 Noviembre | 51 | 21 | 72 |
| 2022 Octubre | 34 | 13 | 47 |
| 2022 Septiembre | 39 | 44 | 83 |
| 2022 Agosto | 26 | 43 | 69 |
| 2022 Julio | 31 | 33 | 64 |
| 2022 Junio | 22 | 28 | 50 |
| 2022 Mayo | 43 | 40 | 83 |
| 2022 Abril | 50 | 42 | 92 |
| 2022 Marzo | 49 | 51 | 100 |
| 2022 Febrero | 39 | 36 | 75 |
| 2022 Enero | 49 | 49 | 98 |
| 2021 Diciembre | 38 | 42 | 80 |
| 2021 Noviembre | 34 | 49 | 83 |
| 2021 Octubre | 44 | 61 | 105 |
| 2021 Septiembre | 38 | 45 | 83 |
| 2021 Agosto | 33 | 40 | 73 |
| 2021 Julio | 26 | 40 | 66 |
| 2021 Junio | 26 | 34 | 60 |
| 2021 Mayo | 44 | 62 | 106 |
| 2021 Abril | 132 | 95 | 227 |
| 2021 Marzo | 74 | 54 | 128 |
| 2021 Febrero | 84 | 59 | 143 |
| 2021 Enero | 50 | 32 | 82 |
| 2020 Diciembre | 50 | 33 | 83 |
| 2020 Noviembre | 42 | 43 | 85 |
| 2020 Octubre | 25 | 15 | 40 |
| 2020 Septiembre | 44 | 31 | 75 |
| 2020 Agosto | 22 | 28 | 50 |
| 2020 Julio | 24 | 19 | 43 |
| 2020 Junio | 32 | 44 | 76 |
| 2020 Mayo | 31 | 29 | 60 |
| 2020 Abril | 13 | 16 | 29 |
| 2020 Marzo | 17 | 16 | 33 |
| 2020 Febrero | 0 | 1 | 1 |
| 2019 Mayo | 1 | 0 | 1 |
Mostrar todo
