array:23 [
  "pii" => "S1578219018301719"
  "issn" => "15782190"
  "doi" => "10.1016/j.adengl.2018.05.013"
  "estado" => "S300"
  "fechaPublicacion" => "2018-07-01"
  "aid" => "1823"
  "copyright" => "Elsevier España, S.L.U. and AEDV"
  "copyrightAnyo" => "2017"
  "documento" => "simple-article"
  "crossmark" => 1
  "subdocumento" => "crp"
  "cita" => "Actas Dermosifiliogr. 2018;109:573-5"
  "abierto" => array:3 [
    "ES" => true
    "ES2" => true
    "LATM" => true
  ]
  "gratuito" => true
  "lecturas" => array:2 [
    "total" => 1
    "PDF" => 1
  ]
  "Traduccion" => array:1 [
    "es" => array:19 [
      "pii" => "S0001731017305574"
      "issn" => "00017310"
      "doi" => "10.1016/j.ad.2017.06.020"
      "estado" => "S300"
      "fechaPublicacion" => "2018-07-01"
      "aid" => "1823"
      "copyright" => "AEDV"
      "documento" => "simple-article"
      "crossmark" => 1
      "subdocumento" => "crp"
      "cita" => "Actas Dermosifiliogr. 2018;109:573-5"
      "abierto" => array:3 [
        "ES" => true
        "ES2" => true
        "LATM" => true
      ]
      "gratuito" => true
      "lecturas" => array:2 [
        "total" => 128
        "formatos" => array:2 [
          "HTML" => 81
          "PDF" => 47
        ]
      ]
      "es" => array:11 [
        "idiomaDefecto" => true
        "cabecera" => "<span class="elsevierStyleTextfn">Carta cient&#237;fico-cl&#237;nica</span>"
        "titulo" => "&#191;Es el signo de Hutchinson patognom&#243;nico de melanoma subungueal&#63;"
        "tienePdf" => "es"
        "tieneTextoCompleto" => "es"
        "paginas" => array:1 [
          0 => array:2 [
            "paginaInicial" => "573"
            "paginaFinal" => "575"
          ]
        ]
        "titulosAlternativos" => array:1 [
          "en" => array:1 [
            "titulo" => "Is Hutchinson&#39;s Sign Pathogonomic of Subungual Melanoma&#63;"
          ]
        ]
        "contieneTextoCompleto" => array:1 [
          "es" => true
        ]
        "contienePdf" => array:1 [
          "es" => true
        ]
        "resumenGrafico" => array:2 [
          "original" => 0
          "multimedia" => array:7 [
            "identificador" => "fig0015"
            "etiqueta" => "Figura 3"
            "tipo" => "MULTIMEDIAFIGURA"
            "mostrarFloat" => true
            "mostrarDisplay" => false
            "figura" => array:1 [
              0 => array:4 [
                "imagen" => "gr3.jpeg"
                "Alto" => 675
                "Ancho" => 900
                "Tamanyo" => 113692
              ]
            ]
            "descripcion" => array:1 [
              "es" => "<p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Hematoxilina-eosina<span class="elsevierStyleHsp" style=""></span>&#215;<span class="elsevierStyleHsp" style=""></span>400&#46; Epitelio escamoso acant&#243;tico con maduraci&#243;n celular adecuada&#44; con melanosis epitelial basal y aislados melan&#243;fagos en estroma&#44; sin proliferaci&#243;n melanoc&#237;tica&#46;</p>"
            ]
          ]
        ]
        "autores" => array:1 [
          0 => array:2 [
            "autoresLista" => "V&#46; Catal&#225;n, M&#46; Yagnam, C&#46; Morales, M&#46; Villagra"
            "autores" => array:4 [
              0 => array:2 [
                "nombre" => "V&#46;"
                "apellidos" => "Catal&#225;n"
              ]
              1 => array:2 [
                "nombre" => "M&#46;"
                "apellidos" => "Yagnam"
              ]
              2 => array:2 [
                "nombre" => "C&#46;"
                "apellidos" => "Morales"
              ]
              3 => array:2 [
                "nombre" => "M&#46;"
                "apellidos" => "Villagra"
              ]
            ]
          ]
        ]
      ]
      "idiomaDefecto" => "es"
      "Traduccion" => array:1 [
        "en" => array:9 [
          "pii" => "S1578219018301719"
          "doi" => "10.1016/j.adengl.2018.05.013"
          "estado" => "S300"
          "subdocumento" => ""
          "abierto" => array:3 [
            "ES" => true
            "ES2" => true
            "LATM" => true
          ]
          "gratuito" => true
          "lecturas" => array:1 [
            "total" => 0
          ]
          "idiomaDefecto" => "en"
          "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1578219018301719?idApp=UINPBA000044"
        ]
      ]
      "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0001731017305574?idApp=UINPBA000044"
      "url" => "/00017310/0000010900000006/v1_201808010427/S0001731017305574/v1_201808010427/es/main.assets"
    ]
  ]
  "itemAnterior" => array:19 [
    "pii" => "S1578219018301756"
    "issn" => "15782190"
    "doi" => "10.1016/j.adengl.2018.05.017"
    "estado" => "S300"
    "fechaPublicacion" => "2018-07-01"
    "aid" => "1824"
    "copyright" => "Elsevier Espa&#241;a&#44; S&#46;L&#46;U&#46; and AEDV"
    "documento" => "simple-article"
    "crossmark" => 1
    "subdocumento" => "crp"
    "cita" => "Actas Dermosifiliogr. 2018;109:570-3"
    "abierto" => array:3 [
      "ES" => true
      "ES2" => true
      "LATM" => true
    ]
    "gratuito" => true
    "lecturas" => array:2 [
      "total" => 17
      "formatos" => array:2 [
        "HTML" => 15
        "PDF" => 2
      ]
    ]
    "en" => array:11 [
      "idiomaDefecto" => true
      "cabecera" => "<span class="elsevierStyleTextfn">Case and Research Letters</span>"
      "titulo" => "Value of Ultrasound as a Diagnostic Tool for a Painful Thoracic Nodule"
      "tienePdf" => "en"
      "tieneTextoCompleto" => "en"
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "570"
          "paginaFinal" => "573"
        ]
      ]
      "titulosAlternativos" => array:1 [
        "es" => array:1 [
          "titulo" => "Utilidad de la ecograf&#237;a en el diagn&#243;stico diferencial de un n&#243;dulo doloroso en el t&#243;rax"
        ]
      ]
      "contieneTextoCompleto" => array:1 [
        "en" => true
      ]
      "contienePdf" => array:1 [
        "en" => true
      ]
      "resumenGrafico" => array:2 [
        "original" => 0
        "multimedia" => array:7 [
          "identificador" => "fig0005"
          "etiqueta" => "Figure 1"
          "tipo" => "MULTIMEDIAFIGURA"
          "mostrarFloat" => true
          "mostrarDisplay" => false
          "figura" => array:1 [
            0 => array:4 [
              "imagen" => "gr1.jpeg"
              "Alto" => 698
              "Ancho" => 1996
              "Tamanyo" => 215763
            ]
          ]
          "descripcion" => array:1 [
            "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">A&#44; Dermatoscopy &#40;DermLite II Pro HR&#44; 3<span class="elsevierStyleHsp" style=""></span>Gen&#41;&#58; central blue-violaceous area surrounded by an erythematous halo&#46; B&#44; Well-differentiated polylobulated tumor in the dermis &#40;hematoxylin-eosin&#44; original magnification<span class="elsevierStyleHsp" style=""></span>&#215;<span class="elsevierStyleHsp" style=""></span>2&#41;&#46; C&#44; The tumor is composed of a biphasic epithelial proliferation comprising small cells arranged around cells with more abundant and clearer cytoplasm that forms ductal structures&#46; No atypia or mitosis is visible &#40;hematoxylin-eosin&#44; original magnification<span class="elsevierStyleHsp" style=""></span>&#215;<span class="elsevierStyleHsp" style=""></span>20&#41;&#46;</p>"
          ]
        ]
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "D&#46; Morgado-Carrasco, S&#46; G&#243;mez, L&#46; Al&#243;s, P&#46; Giavedoni"
          "autores" => array:4 [
            0 => array:2 [
              "nombre" => "D&#46;"
              "apellidos" => "Morgado-Carrasco"
            ]
            1 => array:2 [
              "nombre" => "S&#46;"
              "apellidos" => "G&#243;mez"
            ]
            2 => array:2 [
              "nombre" => "L&#46;"
              "apellidos" => "Al&#243;s"
            ]
            3 => array:2 [
              "nombre" => "P&#46;"
              "apellidos" => "Giavedoni"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "en"
    "Traduccion" => array:1 [
      "es" => array:9 [
        "pii" => "S0001731017305586"
        "doi" => "10.1016/j.ad.2017.09.010"
        "estado" => "S300"
        "subdocumento" => ""
        "abierto" => array:3 [
          "ES" => true
          "ES2" => true
          "LATM" => true
        ]
        "gratuito" => true
        "lecturas" => array:1 [
          "total" => 0
        ]
        "idiomaDefecto" => "es"
        "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0001731017305586?idApp=UINPBA000044"
      ]
    ]
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1578219018301756?idApp=UINPBA000044"
    "url" => "/15782190/0000010900000006/v1_201808010420/S1578219018301756/v1_201808010420/en/main.assets"
  ]
  "en" => array:16 [
    "idiomaDefecto" => true
    "cabecera" => "<span class="elsevierStyleTextfn">Case and Research Letters</span>"
    "titulo" => "Is Hutchinson&#39;s Sign Pathognomic of Subungual Melanoma&#63;"
    "tieneTextoCompleto" => true
    "saludo" => "<span class="elsevierStyleItalic">To the Editor&#58;</span>"
    "paginas" => array:1 [
      0 => array:2 [
        "paginaInicial" => "573"
        "paginaFinal" => "575"
      ]
    ]
    "autores" => array:1 [
      0 => array:4 [
        "autoresLista" => "V&#46; Catal&#225;n, M&#46; Yagnam, C&#46; Morales, M&#46; Villagra"
        "autores" => array:4 [
          0 => array:4 [
            "nombre" => "V&#46;"
            "apellidos" => "Catal&#225;n"
            "email" => array:1 [
              0 => "dravcatalan&#64;gmail&#46;com"
            ]
            "referencia" => array:2 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">a</span>"
                "identificador" => "aff0005"
              ]
              1 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">&#42;</span>"
                "identificador" => "cor0005"
              ]
            ]
          ]
          1 => array:3 [
            "nombre" => "M&#46;"
            "apellidos" => "Yagnam"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">b</span>"
                "identificador" => "aff0010"
              ]
            ]
          ]
          2 => array:3 [
            "nombre" => "C&#46;"
            "apellidos" => "Morales"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">c</span>"
                "identificador" => "aff0015"
              ]
            ]
          ]
          3 => array:3 [
            "nombre" => "M&#46;"
            "apellidos" => "Villagra"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">d</span>"
                "identificador" => "aff0020"
              ]
            ]
          ]
        ]
        "afiliaciones" => array:4 [
          0 => array:3 [
            "entidad" => "Servicio de Dermatolog&#237;a&#44; Hospital Cl&#237;nico Universidad de Chile&#44; Santiago&#44; Chile"
            "etiqueta" => "a"
            "identificador" => "aff0005"
          ]
          1 => array:3 [
            "entidad" => "Departamento de Dermatolog&#237;a&#44; Universidad de Chile&#44; Santiago&#44; Chile"
            "etiqueta" => "b"
            "identificador" => "aff0010"
          ]
          2 => array:3 [
            "entidad" => "Servicio de Anatom&#237;a Patol&#243;gica&#44; Hospital Cl&#237;nico Universidad de Chile&#44; Santiago&#44; Chile"
            "etiqueta" => "c"
            "identificador" => "aff0015"
          ]
          3 => array:3 [
            "entidad" => "Facultad de Medicina&#44; Universidad de Chile&#44; Santiago&#44; Chile"
            "etiqueta" => "d"
            "identificador" => "aff0020"
          ]
        ]
        "correspondencia" => array:1 [
          0 => array:3 [
            "identificador" => "cor0005"
            "etiqueta" => "&#8270;"
            "correspondencia" => "Corresponding author&#46;"
          ]
        ]
      ]
    ]
    "titulosAlternativos" => array:1 [
      "es" => array:1 [
        "titulo" => "&#191;Es el signo de Hutchinson patognom&#243;nico de melanoma subungueal&#63;"
      ]
    ]
    "resumenGrafico" => array:2 [
      "original" => 0
      "multimedia" => array:7 [
        "identificador" => "fig0015"
        "etiqueta" => "Figure 3"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr3.jpeg"
            "Alto" => 675
            "Ancho" => 900
            "Tamanyo" => 113859
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Acanthotic squamous epithelium with adequate cell maturation&#44; epithelial melanosis in the basal layer&#44; and isolated melanophages in the stroma&#46; Note the absence of melanocytic proliferation &#40;hematoxylin-eosin&#44; original magnification &#215;<span class="elsevierStyleHsp" style=""></span>400&#41;&#46;</p>"
        ]
      ]
    ]
    "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">Longitudinal melanonychia is characterized by the presence of light to dark brown or black pigmentation of the nail plate&#46; It occurs in individuals of certain racial origins&#44; such as blacks&#44; Latin Americans&#44; and Asians&#44; but it can also be induced by trauma or drug therapy or found in benign conditions such as infections and melanocytic lesions &#40;e&#46;g&#46;&#44; nail apparatus lentigo and nevi&#41;&#46; It is also a feature of subungual melanoma&#46; Subungual melanoma is a rare malignancy that accounts for approximately 0&#46;7&#37; to 3&#46;5&#37; of all melanomas in the general population&#46;<a class="elsevierStyleCrossRef" href="#bib0055"><span class="elsevierStyleSup">1</span></a> Dermoscopy is a useful tool for the differential diagnosis of longitudinal melanonychia&#46;<a class="elsevierStyleCrossRef" href="#bib0060"><span class="elsevierStyleSup">2</span></a> One of the hallmark signs of subungual melanoma is the Hutchinson sign&#44; which describes periungual pigmentation of the nail folds and hyponychium&#46;<a class="elsevierStyleCrossRefs" href="#bib0065"><span class="elsevierStyleSup">3&#44;4</span></a> The sign has traditionally been associated with poor prognosis in subungual melanoma as it indicates radial growth&#46; Not all Hutchinson signs&#44; however&#44; are associated with subungual melanoma&#46; Some individuals may have a pseudo-Hutchinson sign&#44; which refers to the presence of a dark pigment made visible through a translucent cuticle&#46;<a class="elsevierStyleCrossRefs" href="#bib0070"><span class="elsevierStyleSup">4&#44;5</span></a> In addition&#44; patients with benign melanocytic lesions&#44; such as congenital nevi&#44; may also have periungual pigmentation of the nail folds&#44; raising suspicion of subungual melanoma<a class="elsevierStyleCrossRefs" href="#bib0080"><span class="elsevierStyleSup">6&#8211;8</span></a> even though this tumor is very rare in the pediatric population&#46;</p><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0005">Case Description</span><p id="par0010" class="elsevierStylePara elsevierViewall">A 25-year-old woman presented with longitudinal melanonychia on her right index finger&#46; The pigmentation had been present since the patient was 8 years old and had not changed in appearance&#46; The patient had Fitzpatrick type III skin and the physical examination showed a dark brown band measuring 2<span class="elsevierStyleHsp" style=""></span>mm in width on the right index finger&#46; There was also a notable Hutchinson sign &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>&#41;&#46; The dermoscopic examination showed brown parallel bands along the length of the nail plate and the Hutchinson sign in the proximal and lateral folds &#40;<a class="elsevierStyleCrossRef" href="#fig0010">Fig&#46; 2</a>&#41;&#46; An excisional biopsy of the nail matrix and affected folds showed a mildly acanthotic squamous epithelium with preserved epithelial maturation and epithelial melanosis in the basal layer&#44; but no evidence of lentiginous melanocytic proliferation or melanocyte nests&#46; Periodic acid-Schiff staining was negative and there were no signs of hemorrhage &#40;<a class="elsevierStyleCrossRef" href="#fig0015">Fig&#46; 3</a>&#41;&#46; The findings were consistent with nail apparatus lentigo&#46; The functional and cosmetic results after just a few months were satisfactory&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><elsevierMultimedia ident="fig0010"></elsevierMultimedia><elsevierMultimedia ident="fig0015"></elsevierMultimedia></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0010">Discussion</span><p id="par0015" class="elsevierStylePara elsevierViewall">Determining the benign or malignant nature of melanonychia is challenging and requires 3 steps&#44; the first of which is to determine whether the pigment is melanin&#46; If it is&#44; the second step is to discover whether the increase in melanin is due to melanocytic activation or proliferation&#46; Dermoscopically&#44; gray homogeneous bands suggest activation&#44; while brown or black bands suggest proliferation&#46;<a class="elsevierStyleCrossRef" href="#bib0060"><span class="elsevierStyleSup">2</span></a> The third step is to determine whether the melanocytic proliferation corresponds to a benign condition &#40;acquired&#44; congenital&#44; or lentiginous nevi&#41; or a malignant one &#40;subungual melanoma&#41;&#46; Signs that suggest subungual melanoma include a loss of parallelism&#44; progressive thickening of the nail band&#44; heterogeneous pigmentation&#44; Hutchinson sign&#44; and nail dystrophy&#46;<a class="elsevierStyleCrossRef" href="#bib0060"><span class="elsevierStyleSup">2</span></a> The problem is when a patient has melanonychia with benign features and the Hutchinson sign&#46;</p><p id="par0020" class="elsevierStylePara elsevierViewall">Intraoperative nail matrix dermoscopy has identified dermoscopic patterns that correlate strongly with certain benign lesions and melanoma&#44; and while still in its infancy&#44; this diagnostic modality could be clinically useful in the future&#46;<a class="elsevierStyleCrossRef" href="#bib0095"><span class="elsevierStyleSup">9</span></a></p><p id="par0025" class="elsevierStylePara elsevierViewall">The Hutchinson sign&#44; which was first described in 1886&#44; has always been considered to be strongly suggestive for subungual melanoma&#46; False positives&#44; however&#44; are relatively common and are seen in benign conditions such as Peutz-Jeghers and Laugier-Hunziker syndrome&#44; radiation therapy&#44; drug therapy &#40;minocycline&#41;&#44; trauma-induced injuries&#44; congenital nevi&#44; ethnic pigmentation&#44; and systemic diseases&#44; such as hyperthyroidism&#44; Cushing syndrome&#44; and deposition disorders&#46;<a class="elsevierStyleCrossRefs" href="#bib0060"><span class="elsevierStyleSup">2&#44;3</span></a> Congenital nevi may also exhibit signs of malignancy&#44; such as the Hutchinson sign and progressive darkening and thickening of the nail band&#46;<a class="elsevierStyleCrossRefs" href="#bib0080"><span class="elsevierStyleSup">6&#8211;8</span></a></p><p id="par0030" class="elsevierStylePara elsevierViewall">Our patient had had longitudinal melanonychia since childhood and had experienced no changes&#46; We performed a biopsy because of the Hutchinson sign&#44; even though the dermoscopic image showed a parallel lesion with uniform coloring &#40;<a class="elsevierStyleCrossRef" href="#fig0010">Fig&#46; 2</a>&#41;&#46; It is important to note that the Hutchinson sign is not considered pathognomonic for melanoma and this is particularly true for children&#44; where clinical and dermoscopic criteria have not been validated as they have for adults&#46;<a class="elsevierStyleCrossRefs" href="#bib0080"><span class="elsevierStyleSup">6&#44;10</span></a> We have presented this case because it provides an example of a false positive for subungual melanoma&#46; We do&#44; however&#44; strongly recommend performing biopsy whenever the Hutchinson sign is observed due to its close association with subungual melanoma&#46;</p></span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0015">Conflicts of Interest</span><p id="par0035" class="elsevierStylePara elsevierViewall">The authors declare that they have no conflicts of interest&#46;</p></span></span>"
    "textoCompletoSecciones" => array:1 [
      "secciones" => array:4 [
        0 => array:2 [
          "identificador" => "sec0005"
          "titulo" => "Case Description"
        ]
        1 => array:2 [
          "identificador" => "sec0010"
          "titulo" => "Discussion"
        ]
        2 => array:2 [
          "identificador" => "sec0015"
          "titulo" => "Conflicts of Interest"
        ]
        3 => array:1 [
          "titulo" => "References"
        ]
      ]
    ]
    "pdfFichero" => "main.pdf"
    "tienePdf" => true
    "NotaPie" => array:1 [
      0 => array:2 [
        "etiqueta" => "&#9734;"
        "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Please cite this article as&#58; Catal&#225;n V&#44; Yagnam M&#44; Morales C&#44; Villagra M&#46; &#191;Es el signo de Hutchinson patognom&#243;nico de melanoma subungueal&#46; Actas Dermosifiliogr&#46; 2018&#59;109&#58;573&#8211;575&#46;</p>"
      ]
    ]
    "multimedia" => array:3 [
      0 => array:7 [
        "identificador" => "fig0005"
        "etiqueta" => "Figure 1"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr1.jpeg"
            "Alto" => 675
            "Ancho" => 900
            "Tamanyo" => 108438
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Clinical appearance&#58; longitudinal melanonychia with periungual pigmentation &#40;Hutchinson sign&#41;&#46;</p>"
        ]
      ]
      1 => array:7 [
        "identificador" => "fig0010"
        "etiqueta" => "Figure 2"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr2.jpeg"
            "Alto" => 835
            "Ancho" => 900
            "Tamanyo" => 42790
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Dermoscopy findings&#58; regular&#44; parallel bands&#44; brown pigmentation of proximal and lateral nail folds &#40;Hutchinson sign&#41;&#46;</p>"
        ]
      ]
      2 => array:7 [
        "identificador" => "fig0015"
        "etiqueta" => "Figure 3"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr3.jpeg"
            "Alto" => 675
            "Ancho" => 900
            "Tamanyo" => 113859
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Acanthotic squamous epithelium with adequate cell maturation&#44; epithelial melanosis in the basal layer&#44; and isolated melanophages in the stroma&#46; Note the absence of melanocytic proliferation &#40;hematoxylin-eosin&#44; original magnification &#215;<span class="elsevierStyleHsp" style=""></span>400&#41;&#46;</p>"
        ]
      ]
    ]
    "bibliografia" => array:2 [
      "titulo" => "References"
      "seccion" => array:1 [
        0 => array:2 [
          "identificador" => "bibs0015"
          "bibliografiaReferencia" => array:10 [
            0 => array:3 [
              "identificador" => "bib0055"
              "etiqueta" => "1"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Subungual melanoma&#58; A deceptive disorder"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "G&#46;A&#46; Patel"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Acta Dermatovenerol Croat"
                        "fecha" => "2008"
                        "volumen" => "16"
                        "paginaInicial" => "236"
                        "paginaFinal" => "242"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19111151"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            1 => array:3 [
              "identificador" => "bib0060"
              "etiqueta" => "2"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Key point in dermoscopic differentiation between early nail apparatus melanoma and benign longitudinal melanonychia"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "H&#46; Koga"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1111/j.1346-8138.2010.01175.x"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Dermatol"
                        "fecha" => "2011"
                        "volumen" => "38"
                        "paginaInicial" => "45"
                        "paginaFinal" => "52"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/21175755"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            2 => array:3 [
              "identificador" => "bib0065"
              "etiqueta" => "3"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Hutchinson&#39;s sign&#58; A reappraisal"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "R&#46; Baran"
                            1 => "P&#46; Kechijian"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "J Am Acad Dermatol"
                        "fecha" => "1996"
                        "volumen" => "34"
                        "paginaInicial" => "87"
                        "paginaFinal" => "90"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8543700"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            3 => array:3 [
              "identificador" => "bib0070"
              "etiqueta" => "4"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:1 [
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "E&#46;K&#46; Levit"
                            1 => "M&#46;H&#46; Kagen"
                            2 => "R&#46;K&#46; Scher"
                            3 => "M&#46; Grossman"
                            4 => "E&#46;AT The ABC rule for clinical detection of subungual melanoma Altman"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/S0190-9622(00)90137-3"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Am Acad Dermatol"
                        "fecha" => "2000"
                        "volumen" => "42"
                        "paginaInicial" => "269"
                        "paginaFinal" => "274"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10642684"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            4 => array:3 [
              "identificador" => "bib0075"
              "etiqueta" => "5"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Two kinds of Hutchinson&#39;s sign&#44; benign and malignant"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "Y&#46; Kawabata"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1067/mjd.2001.112398"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Am Acad Dermatol"
                        "fecha" => "2001"
                        "volumen" => "44"
                        "paginaInicial" => "305"
                        "paginaFinal" => "307"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11174394"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            5 => array:3 [
              "identificador" => "bib0080"
              "etiqueta" => "6"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Clinical and histopathologic characteristics of early lesions of subungual malignant melanoma"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "T&#46; Saida"
                            1 => "Y&#46; Ohshima"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Cancer"
                        "fecha" => "1989"
                        "volumen" => "63"
                        "paginaInicial" => "556"
                        "paginaFinal" => "560"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/2912531"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            6 => array:3 [
              "identificador" => "bib0085"
              "etiqueta" => "7"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "A clinical&#44; histopathologic&#44; and outcome study of melanonychia striata in childhood"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "C&#46; Cooper"
                            1 => "N&#46;C&#46; Arva"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.jaad.2015.01.010"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Am Acad Dermatol"
                        "fecha" => "2015"
                        "volumen" => "72"
                        "paginaInicial" => "773"
                        "paginaFinal" => "779"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/25766363"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            7 => array:3 [
              "identificador" => "bib0090"
              "etiqueta" => "8"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Congenital subungual melanocytic nevus with a pseudo-Hutchinson sign"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "A&#46;M&#46; Goldminz"
                            1 => "D&#46; Wolpowitz"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Dermatol Online J"
                        "fecha" => "2013"
                        "volumen" => "19"
                        "paginaInicial" => "8"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/24021368"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            8 => array:3 [
              "identificador" => "bib0095"
              "etiqueta" => "9"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Patterns of nail matrix and bed of longitudinal melanonychia by intraoperative dermatoscopy"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "S&#46;H&#46; Hirata"
                            1 => "S&#46; Yamada"
                            2 => "M&#46;Y&#46; Enokihara"
                            3 => "N&#46; Di Chiacchio"
                            4 => "F&#46;A&#46; de Almeida"
                            5 => "M&#46;M&#46; Enokihara"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.jaad.2010.06.009"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Am Acad Dermatol"
                        "fecha" => "2011"
                        "volumen" => "65"
                        "paginaInicial" => "297"
                        "paginaFinal" => "303"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/21531039"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            9 => array:3 [
              "identificador" => "bib0100"
              "etiqueta" => "10"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "In situ melanoma of the nail unit in children&#58; Report of two cases in fair-skinned Caucasian children"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "A&#46; Tosti"
                            1 => "B&#46; Piraccini"
                            2 => "A&#46; Cagalli"
                            3 => "E&#46; Haneke"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1111/j.1525-1470.2011.01481.x"
                      "Revista" => array:6 [
                        "tituloSerie" => "Pediatr Dermatol"
                        "fecha" => "2012"
                        "volumen" => "29"
                        "paginaInicial" => "79"
                        "paginaFinal" => "83"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/21575049"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
          ]
        ]
      ]
    ]
  ]
  "idiomaDefecto" => "en"
  "url" => "/15782190/0000010900000006/v1_201808010420/S1578219018301719/v1_201808010420/en/main.assets"
  "Apartado" => array:4 [
    "identificador" => "6157"
    "tipo" => "SECCION"
    "en" => array:2 [
      "titulo" => "Case and Research Letters"
      "idiomaDefecto" => true
    ]
    "idiomaDefecto" => "en"
  ]
  "PDF" => "https://static.elsevier.es/multimedia/15782190/0000010900000006/v1_201808010420/S1578219018301719/v1_201808010420/en/main.pdf?idApp=UINPBA000044&text.app=https://actasdermo.org/"
  "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1578219018301719?idApp=UINPBA000044"
]
Compartir
Información de la revista

Estadísticas

Siga este enlace para acceder al texto completo del artículo

Case and Research Letters
Is Hutchinson's Sign Pathognomic of Subungual Melanoma?
¿Es el signo de Hutchinson patognomónico de melanoma subungueal?
V. Catalána,
Autor para correspondencia
dravcatalan@gmail.com

Corresponding author.
, M. Yagnamb, C. Moralesc, M. Villagrad
a Servicio de Dermatología, Hospital Clínico Universidad de Chile, Santiago, Chile
b Departamento de Dermatología, Universidad de Chile, Santiago, Chile
c Servicio de Anatomía Patológica, Hospital Clínico Universidad de Chile, Santiago, Chile
d Facultad de Medicina, Universidad de Chile, Santiago, Chile
Leído
47687
Veces
se ha leído el artículo
2582
Total PDF
45105
Total HTML
Compartir estadísticas
 array:23 [
  "pii" => "S1578219018301719"
  "issn" => "15782190"
  "doi" => "10.1016/j.adengl.2018.05.013"
  "estado" => "S300"
  "fechaPublicacion" => "2018-07-01"
  "aid" => "1823"
  "copyright" => "Elsevier Espa&#241;a&#44; S&#46;L&#46;U&#46; and AEDV"
  "copyrightAnyo" => "2017"
  "documento" => "simple-article"
  "crossmark" => 1
  "subdocumento" => "crp"
  "cita" => "Actas Dermosifiliogr. 2018;109:573-5"
  "abierto" => array:3 [
    "ES" => true
    "ES2" => true
    "LATM" => true
  ]
  "gratuito" => true
  "lecturas" => array:2 [
    "total" => 1
    "PDF" => 1
  ]
  "Traduccion" => array:1 [
    "es" => array:19 [
      "pii" => "S0001731017305574"
      "issn" => "00017310"
      "doi" => "10.1016/j.ad.2017.06.020"
      "estado" => "S300"
      "fechaPublicacion" => "2018-07-01"
      "aid" => "1823"
      "copyright" => "AEDV"
      "documento" => "simple-article"
      "crossmark" => 1
      "subdocumento" => "crp"
      "cita" => "Actas Dermosifiliogr. 2018;109:573-5"
      "abierto" => array:3 [
        "ES" => true
        "ES2" => true
        "LATM" => true
      ]
      "gratuito" => true
      "lecturas" => array:2 [
        "total" => 128
        "formatos" => array:2 [
          "HTML" => 81
          "PDF" => 47
        ]
      ]
      "es" => array:11 [
        "idiomaDefecto" => true
        "cabecera" => "<span class="elsevierStyleTextfn">Carta cient&#237;fico-cl&#237;nica</span>"
        "titulo" => "&#191;Es el signo de Hutchinson patognom&#243;nico de melanoma subungueal&#63;"
        "tienePdf" => "es"
        "tieneTextoCompleto" => "es"
        "paginas" => array:1 [
          0 => array:2 [
            "paginaInicial" => "573"
            "paginaFinal" => "575"
          ]
        ]
        "titulosAlternativos" => array:1 [
          "en" => array:1 [
            "titulo" => "Is Hutchinson&#39;s Sign Pathogonomic of Subungual Melanoma&#63;"
          ]
        ]
        "contieneTextoCompleto" => array:1 [
          "es" => true
        ]
        "contienePdf" => array:1 [
          "es" => true
        ]
        "resumenGrafico" => array:2 [
          "original" => 0
          "multimedia" => array:7 [
            "identificador" => "fig0015"
            "etiqueta" => "Figura 3"
            "tipo" => "MULTIMEDIAFIGURA"
            "mostrarFloat" => true
            "mostrarDisplay" => false
            "figura" => array:1 [
              0 => array:4 [
                "imagen" => "gr3.jpeg"
                "Alto" => 675
                "Ancho" => 900
                "Tamanyo" => 113692
              ]
            ]
            "descripcion" => array:1 [
              "es" => "<p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Hematoxilina-eosina<span class="elsevierStyleHsp" style=""></span>&#215;<span class="elsevierStyleHsp" style=""></span>400&#46; Epitelio escamoso acant&#243;tico con maduraci&#243;n celular adecuada&#44; con melanosis epitelial basal y aislados melan&#243;fagos en estroma&#44; sin proliferaci&#243;n melanoc&#237;tica&#46;</p>"
            ]
          ]
        ]
        "autores" => array:1 [
          0 => array:2 [
            "autoresLista" => "V&#46; Catal&#225;n, M&#46; Yagnam, C&#46; Morales, M&#46; Villagra"
            "autores" => array:4 [
              0 => array:2 [
                "nombre" => "V&#46;"
                "apellidos" => "Catal&#225;n"
              ]
              1 => array:2 [
                "nombre" => "M&#46;"
                "apellidos" => "Yagnam"
              ]
              2 => array:2 [
                "nombre" => "C&#46;"
                "apellidos" => "Morales"
              ]
              3 => array:2 [
                "nombre" => "M&#46;"
                "apellidos" => "Villagra"
              ]
            ]
          ]
        ]
      ]
      "idiomaDefecto" => "es"
      "Traduccion" => array:1 [
        "en" => array:9 [
          "pii" => "S1578219018301719"
          "doi" => "10.1016/j.adengl.2018.05.013"
          "estado" => "S300"
          "subdocumento" => ""
          "abierto" => array:3 [
            "ES" => true
            "ES2" => true
            "LATM" => true
          ]
          "gratuito" => true
          "lecturas" => array:1 [
            "total" => 0
          ]
          "idiomaDefecto" => "en"
          "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1578219018301719?idApp=UINPBA000044"
        ]
      ]
      "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0001731017305574?idApp=UINPBA000044"
      "url" => "/00017310/0000010900000006/v1_201808010427/S0001731017305574/v1_201808010427/es/main.assets"
    ]
  ]
  "itemAnterior" => array:19 [
    "pii" => "S1578219018301756"
    "issn" => "15782190"
    "doi" => "10.1016/j.adengl.2018.05.017"
    "estado" => "S300"
    "fechaPublicacion" => "2018-07-01"
    "aid" => "1824"
    "copyright" => "Elsevier Espa&#241;a&#44; S&#46;L&#46;U&#46; and AEDV"
    "documento" => "simple-article"
    "crossmark" => 1
    "subdocumento" => "crp"
    "cita" => "Actas Dermosifiliogr. 2018;109:570-3"
    "abierto" => array:3 [
      "ES" => true
      "ES2" => true
      "LATM" => true
    ]
    "gratuito" => true
    "lecturas" => array:2 [
      "total" => 17
      "formatos" => array:2 [
        "HTML" => 15
        "PDF" => 2
      ]
    ]
    "en" => array:11 [
      "idiomaDefecto" => true
      "cabecera" => "<span class="elsevierStyleTextfn">Case and Research Letters</span>"
      "titulo" => "Value of Ultrasound as a Diagnostic Tool for a Painful Thoracic Nodule"
      "tienePdf" => "en"
      "tieneTextoCompleto" => "en"
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "570"
          "paginaFinal" => "573"
        ]
      ]
      "titulosAlternativos" => array:1 [
        "es" => array:1 [
          "titulo" => "Utilidad de la ecograf&#237;a en el diagn&#243;stico diferencial de un n&#243;dulo doloroso en el t&#243;rax"
        ]
      ]
      "contieneTextoCompleto" => array:1 [
        "en" => true
      ]
      "contienePdf" => array:1 [
        "en" => true
      ]
      "resumenGrafico" => array:2 [
        "original" => 0
        "multimedia" => array:7 [
          "identificador" => "fig0005"
          "etiqueta" => "Figure 1"
          "tipo" => "MULTIMEDIAFIGURA"
          "mostrarFloat" => true
          "mostrarDisplay" => false
          "figura" => array:1 [
            0 => array:4 [
              "imagen" => "gr1.jpeg"
              "Alto" => 698
              "Ancho" => 1996
              "Tamanyo" => 215763
            ]
          ]
          "descripcion" => array:1 [
            "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">A&#44; Dermatoscopy &#40;DermLite II Pro HR&#44; 3<span class="elsevierStyleHsp" style=""></span>Gen&#41;&#58; central blue-violaceous area surrounded by an erythematous halo&#46; B&#44; Well-differentiated polylobulated tumor in the dermis &#40;hematoxylin-eosin&#44; original magnification<span class="elsevierStyleHsp" style=""></span>&#215;<span class="elsevierStyleHsp" style=""></span>2&#41;&#46; C&#44; The tumor is composed of a biphasic epithelial proliferation comprising small cells arranged around cells with more abundant and clearer cytoplasm that forms ductal structures&#46; No atypia or mitosis is visible &#40;hematoxylin-eosin&#44; original magnification<span class="elsevierStyleHsp" style=""></span>&#215;<span class="elsevierStyleHsp" style=""></span>20&#41;&#46;</p>"
          ]
        ]
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "D&#46; Morgado-Carrasco, S&#46; G&#243;mez, L&#46; Al&#243;s, P&#46; Giavedoni"
          "autores" => array:4 [
            0 => array:2 [
              "nombre" => "D&#46;"
              "apellidos" => "Morgado-Carrasco"
            ]
            1 => array:2 [
              "nombre" => "S&#46;"
              "apellidos" => "G&#243;mez"
            ]
            2 => array:2 [
              "nombre" => "L&#46;"
              "apellidos" => "Al&#243;s"
            ]
            3 => array:2 [
              "nombre" => "P&#46;"
              "apellidos" => "Giavedoni"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "en"
    "Traduccion" => array:1 [
      "es" => array:9 [
        "pii" => "S0001731017305586"
        "doi" => "10.1016/j.ad.2017.09.010"
        "estado" => "S300"
        "subdocumento" => ""
        "abierto" => array:3 [
          "ES" => true
          "ES2" => true
          "LATM" => true
        ]
        "gratuito" => true
        "lecturas" => array:1 [
          "total" => 0
        ]
        "idiomaDefecto" => "es"
        "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0001731017305586?idApp=UINPBA000044"
      ]
    ]
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1578219018301756?idApp=UINPBA000044"
    "url" => "/15782190/0000010900000006/v1_201808010420/S1578219018301756/v1_201808010420/en/main.assets"
  ]
  "en" => array:16 [
    "idiomaDefecto" => true
    "cabecera" => "<span class="elsevierStyleTextfn">Case and Research Letters</span>"
    "titulo" => "Is Hutchinson&#39;s Sign Pathognomic of Subungual Melanoma&#63;"
    "tieneTextoCompleto" => true
    "saludo" => "<span class="elsevierStyleItalic">To the Editor&#58;</span>"
    "paginas" => array:1 [
      0 => array:2 [
        "paginaInicial" => "573"
        "paginaFinal" => "575"
      ]
    ]
    "autores" => array:1 [
      0 => array:4 [
        "autoresLista" => "V&#46; Catal&#225;n, M&#46; Yagnam, C&#46; Morales, M&#46; Villagra"
        "autores" => array:4 [
          0 => array:4 [
            "nombre" => "V&#46;"
            "apellidos" => "Catal&#225;n"
            "email" => array:1 [
              0 => "dravcatalan&#64;gmail&#46;com"
            ]
            "referencia" => array:2 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">a</span>"
                "identificador" => "aff0005"
              ]
              1 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">&#42;</span>"
                "identificador" => "cor0005"
              ]
            ]
          ]
          1 => array:3 [
            "nombre" => "M&#46;"
            "apellidos" => "Yagnam"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">b</span>"
                "identificador" => "aff0010"
              ]
            ]
          ]
          2 => array:3 [
            "nombre" => "C&#46;"
            "apellidos" => "Morales"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">c</span>"
                "identificador" => "aff0015"
              ]
            ]
          ]
          3 => array:3 [
            "nombre" => "M&#46;"
            "apellidos" => "Villagra"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">d</span>"
                "identificador" => "aff0020"
              ]
            ]
          ]
        ]
        "afiliaciones" => array:4 [
          0 => array:3 [
            "entidad" => "Servicio de Dermatolog&#237;a&#44; Hospital Cl&#237;nico Universidad de Chile&#44; Santiago&#44; Chile"
            "etiqueta" => "a"
            "identificador" => "aff0005"
          ]
          1 => array:3 [
            "entidad" => "Departamento de Dermatolog&#237;a&#44; Universidad de Chile&#44; Santiago&#44; Chile"
            "etiqueta" => "b"
            "identificador" => "aff0010"
          ]
          2 => array:3 [
            "entidad" => "Servicio de Anatom&#237;a Patol&#243;gica&#44; Hospital Cl&#237;nico Universidad de Chile&#44; Santiago&#44; Chile"
            "etiqueta" => "c"
            "identificador" => "aff0015"
          ]
          3 => array:3 [
            "entidad" => "Facultad de Medicina&#44; Universidad de Chile&#44; Santiago&#44; Chile"
            "etiqueta" => "d"
            "identificador" => "aff0020"
          ]
        ]
        "correspondencia" => array:1 [
          0 => array:3 [
            "identificador" => "cor0005"
            "etiqueta" => "&#8270;"
            "correspondencia" => "Corresponding author&#46;"
          ]
        ]
      ]
    ]
    "titulosAlternativos" => array:1 [
      "es" => array:1 [
        "titulo" => "&#191;Es el signo de Hutchinson patognom&#243;nico de melanoma subungueal&#63;"
      ]
    ]
    "resumenGrafico" => array:2 [
      "original" => 0
      "multimedia" => array:7 [
        "identificador" => "fig0015"
        "etiqueta" => "Figure 3"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr3.jpeg"
            "Alto" => 675
            "Ancho" => 900
            "Tamanyo" => 113859
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Acanthotic squamous epithelium with adequate cell maturation&#44; epithelial melanosis in the basal layer&#44; and isolated melanophages in the stroma&#46; Note the absence of melanocytic proliferation &#40;hematoxylin-eosin&#44; original magnification &#215;<span class="elsevierStyleHsp" style=""></span>400&#41;&#46;</p>"
        ]
      ]
    ]
    "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">Longitudinal melanonychia is characterized by the presence of light to dark brown or black pigmentation of the nail plate&#46; It occurs in individuals of certain racial origins&#44; such as blacks&#44; Latin Americans&#44; and Asians&#44; but it can also be induced by trauma or drug therapy or found in benign conditions such as infections and melanocytic lesions &#40;e&#46;g&#46;&#44; nail apparatus lentigo and nevi&#41;&#46; It is also a feature of subungual melanoma&#46; Subungual melanoma is a rare malignancy that accounts for approximately 0&#46;7&#37; to 3&#46;5&#37; of all melanomas in the general population&#46;<a class="elsevierStyleCrossRef" href="#bib0055"><span class="elsevierStyleSup">1</span></a> Dermoscopy is a useful tool for the differential diagnosis of longitudinal melanonychia&#46;<a class="elsevierStyleCrossRef" href="#bib0060"><span class="elsevierStyleSup">2</span></a> One of the hallmark signs of subungual melanoma is the Hutchinson sign&#44; which describes periungual pigmentation of the nail folds and hyponychium&#46;<a class="elsevierStyleCrossRefs" href="#bib0065"><span class="elsevierStyleSup">3&#44;4</span></a> The sign has traditionally been associated with poor prognosis in subungual melanoma as it indicates radial growth&#46; Not all Hutchinson signs&#44; however&#44; are associated with subungual melanoma&#46; Some individuals may have a pseudo-Hutchinson sign&#44; which refers to the presence of a dark pigment made visible through a translucent cuticle&#46;<a class="elsevierStyleCrossRefs" href="#bib0070"><span class="elsevierStyleSup">4&#44;5</span></a> In addition&#44; patients with benign melanocytic lesions&#44; such as congenital nevi&#44; may also have periungual pigmentation of the nail folds&#44; raising suspicion of subungual melanoma<a class="elsevierStyleCrossRefs" href="#bib0080"><span class="elsevierStyleSup">6&#8211;8</span></a> even though this tumor is very rare in the pediatric population&#46;</p><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0005">Case Description</span><p id="par0010" class="elsevierStylePara elsevierViewall">A 25-year-old woman presented with longitudinal melanonychia on her right index finger&#46; The pigmentation had been present since the patient was 8 years old and had not changed in appearance&#46; The patient had Fitzpatrick type III skin and the physical examination showed a dark brown band measuring 2<span class="elsevierStyleHsp" style=""></span>mm in width on the right index finger&#46; There was also a notable Hutchinson sign &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>&#41;&#46; The dermoscopic examination showed brown parallel bands along the length of the nail plate and the Hutchinson sign in the proximal and lateral folds &#40;<a class="elsevierStyleCrossRef" href="#fig0010">Fig&#46; 2</a>&#41;&#46; An excisional biopsy of the nail matrix and affected folds showed a mildly acanthotic squamous epithelium with preserved epithelial maturation and epithelial melanosis in the basal layer&#44; but no evidence of lentiginous melanocytic proliferation or melanocyte nests&#46; Periodic acid-Schiff staining was negative and there were no signs of hemorrhage &#40;<a class="elsevierStyleCrossRef" href="#fig0015">Fig&#46; 3</a>&#41;&#46; The findings were consistent with nail apparatus lentigo&#46; The functional and cosmetic results after just a few months were satisfactory&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><elsevierMultimedia ident="fig0010"></elsevierMultimedia><elsevierMultimedia ident="fig0015"></elsevierMultimedia></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0010">Discussion</span><p id="par0015" class="elsevierStylePara elsevierViewall">Determining the benign or malignant nature of melanonychia is challenging and requires 3 steps&#44; the first of which is to determine whether the pigment is melanin&#46; If it is&#44; the second step is to discover whether the increase in melanin is due to melanocytic activation or proliferation&#46; Dermoscopically&#44; gray homogeneous bands suggest activation&#44; while brown or black bands suggest proliferation&#46;<a class="elsevierStyleCrossRef" href="#bib0060"><span class="elsevierStyleSup">2</span></a> The third step is to determine whether the melanocytic proliferation corresponds to a benign condition &#40;acquired&#44; congenital&#44; or lentiginous nevi&#41; or a malignant one &#40;subungual melanoma&#41;&#46; Signs that suggest subungual melanoma include a loss of parallelism&#44; progressive thickening of the nail band&#44; heterogeneous pigmentation&#44; Hutchinson sign&#44; and nail dystrophy&#46;<a class="elsevierStyleCrossRef" href="#bib0060"><span class="elsevierStyleSup">2</span></a> The problem is when a patient has melanonychia with benign features and the Hutchinson sign&#46;</p><p id="par0020" class="elsevierStylePara elsevierViewall">Intraoperative nail matrix dermoscopy has identified dermoscopic patterns that correlate strongly with certain benign lesions and melanoma&#44; and while still in its infancy&#44; this diagnostic modality could be clinically useful in the future&#46;<a class="elsevierStyleCrossRef" href="#bib0095"><span class="elsevierStyleSup">9</span></a></p><p id="par0025" class="elsevierStylePara elsevierViewall">The Hutchinson sign&#44; which was first described in 1886&#44; has always been considered to be strongly suggestive for subungual melanoma&#46; False positives&#44; however&#44; are relatively common and are seen in benign conditions such as Peutz-Jeghers and Laugier-Hunziker syndrome&#44; radiation therapy&#44; drug therapy &#40;minocycline&#41;&#44; trauma-induced injuries&#44; congenital nevi&#44; ethnic pigmentation&#44; and systemic diseases&#44; such as hyperthyroidism&#44; Cushing syndrome&#44; and deposition disorders&#46;<a class="elsevierStyleCrossRefs" href="#bib0060"><span class="elsevierStyleSup">2&#44;3</span></a> Congenital nevi may also exhibit signs of malignancy&#44; such as the Hutchinson sign and progressive darkening and thickening of the nail band&#46;<a class="elsevierStyleCrossRefs" href="#bib0080"><span class="elsevierStyleSup">6&#8211;8</span></a></p><p id="par0030" class="elsevierStylePara elsevierViewall">Our patient had had longitudinal melanonychia since childhood and had experienced no changes&#46; We performed a biopsy because of the Hutchinson sign&#44; even though the dermoscopic image showed a parallel lesion with uniform coloring &#40;<a class="elsevierStyleCrossRef" href="#fig0010">Fig&#46; 2</a>&#41;&#46; It is important to note that the Hutchinson sign is not considered pathognomonic for melanoma and this is particularly true for children&#44; where clinical and dermoscopic criteria have not been validated as they have for adults&#46;<a class="elsevierStyleCrossRefs" href="#bib0080"><span class="elsevierStyleSup">6&#44;10</span></a> We have presented this case because it provides an example of a false positive for subungual melanoma&#46; We do&#44; however&#44; strongly recommend performing biopsy whenever the Hutchinson sign is observed due to its close association with subungual melanoma&#46;</p></span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0015">Conflicts of Interest</span><p id="par0035" class="elsevierStylePara elsevierViewall">The authors declare that they have no conflicts of interest&#46;</p></span></span>"
    "textoCompletoSecciones" => array:1 [
      "secciones" => array:4 [
        0 => array:2 [
          "identificador" => "sec0005"
          "titulo" => "Case Description"
        ]
        1 => array:2 [
          "identificador" => "sec0010"
          "titulo" => "Discussion"
        ]
        2 => array:2 [
          "identificador" => "sec0015"
          "titulo" => "Conflicts of Interest"
        ]
        3 => array:1 [
          "titulo" => "References"
        ]
      ]
    ]
    "pdfFichero" => "main.pdf"
    "tienePdf" => true
    "NotaPie" => array:1 [
      0 => array:2 [
        "etiqueta" => "&#9734;"
        "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Please cite this article as&#58; Catal&#225;n V&#44; Yagnam M&#44; Morales C&#44; Villagra M&#46; &#191;Es el signo de Hutchinson patognom&#243;nico de melanoma subungueal&#46; Actas Dermosifiliogr&#46; 2018&#59;109&#58;573&#8211;575&#46;</p>"
      ]
    ]
    "multimedia" => array:3 [
      0 => array:7 [
        "identificador" => "fig0005"
        "etiqueta" => "Figure 1"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr1.jpeg"
            "Alto" => 675
            "Ancho" => 900
            "Tamanyo" => 108438
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Clinical appearance&#58; longitudinal melanonychia with periungual pigmentation &#40;Hutchinson sign&#41;&#46;</p>"
        ]
      ]
      1 => array:7 [
        "identificador" => "fig0010"
        "etiqueta" => "Figure 2"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr2.jpeg"
            "Alto" => 835
            "Ancho" => 900
            "Tamanyo" => 42790
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Dermoscopy findings&#58; regular&#44; parallel bands&#44; brown pigmentation of proximal and lateral nail folds &#40;Hutchinson sign&#41;&#46;</p>"
        ]
      ]
      2 => array:7 [
        "identificador" => "fig0015"
        "etiqueta" => "Figure 3"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr3.jpeg"
            "Alto" => 675
            "Ancho" => 900
            "Tamanyo" => 113859
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Acanthotic squamous epithelium with adequate cell maturation&#44; epithelial melanosis in the basal layer&#44; and isolated melanophages in the stroma&#46; Note the absence of melanocytic proliferation &#40;hematoxylin-eosin&#44; original magnification &#215;<span class="elsevierStyleHsp" style=""></span>400&#41;&#46;</p>"
        ]
      ]
    ]
    "bibliografia" => array:2 [
      "titulo" => "References"
      "seccion" => array:1 [
        0 => array:2 [
          "identificador" => "bibs0015"
          "bibliografiaReferencia" => array:10 [
            0 => array:3 [
              "identificador" => "bib0055"
              "etiqueta" => "1"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Subungual melanoma&#58; A deceptive disorder"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "G&#46;A&#46; Patel"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Acta Dermatovenerol Croat"
                        "fecha" => "2008"
                        "volumen" => "16"
                        "paginaInicial" => "236"
                        "paginaFinal" => "242"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19111151"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            1 => array:3 [
              "identificador" => "bib0060"
              "etiqueta" => "2"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Key point in dermoscopic differentiation between early nail apparatus melanoma and benign longitudinal melanonychia"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "H&#46; Koga"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1111/j.1346-8138.2010.01175.x"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Dermatol"
                        "fecha" => "2011"
                        "volumen" => "38"
                        "paginaInicial" => "45"
                        "paginaFinal" => "52"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/21175755"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            2 => array:3 [
              "identificador" => "bib0065"
              "etiqueta" => "3"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Hutchinson&#39;s sign&#58; A reappraisal"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "R&#46; Baran"
                            1 => "P&#46; Kechijian"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "J Am Acad Dermatol"
                        "fecha" => "1996"
                        "volumen" => "34"
                        "paginaInicial" => "87"
                        "paginaFinal" => "90"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8543700"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            3 => array:3 [
              "identificador" => "bib0070"
              "etiqueta" => "4"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:1 [
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "E&#46;K&#46; Levit"
                            1 => "M&#46;H&#46; Kagen"
                            2 => "R&#46;K&#46; Scher"
                            3 => "M&#46; Grossman"
                            4 => "E&#46;AT The ABC rule for clinical detection of subungual melanoma Altman"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/S0190-9622(00)90137-3"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Am Acad Dermatol"
                        "fecha" => "2000"
                        "volumen" => "42"
                        "paginaInicial" => "269"
                        "paginaFinal" => "274"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10642684"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            4 => array:3 [
              "identificador" => "bib0075"
              "etiqueta" => "5"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Two kinds of Hutchinson&#39;s sign&#44; benign and malignant"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "Y&#46; Kawabata"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1067/mjd.2001.112398"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Am Acad Dermatol"
                        "fecha" => "2001"
                        "volumen" => "44"
                        "paginaInicial" => "305"
                        "paginaFinal" => "307"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11174394"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            5 => array:3 [
              "identificador" => "bib0080"
              "etiqueta" => "6"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Clinical and histopathologic characteristics of early lesions of subungual malignant melanoma"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "T&#46; Saida"
                            1 => "Y&#46; Ohshima"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Cancer"
                        "fecha" => "1989"
                        "volumen" => "63"
                        "paginaInicial" => "556"
                        "paginaFinal" => "560"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/2912531"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            6 => array:3 [
              "identificador" => "bib0085"
              "etiqueta" => "7"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "A clinical&#44; histopathologic&#44; and outcome study of melanonychia striata in childhood"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "C&#46; Cooper"
                            1 => "N&#46;C&#46; Arva"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.jaad.2015.01.010"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Am Acad Dermatol"
                        "fecha" => "2015"
                        "volumen" => "72"
                        "paginaInicial" => "773"
                        "paginaFinal" => "779"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/25766363"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            7 => array:3 [
              "identificador" => "bib0090"
              "etiqueta" => "8"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Congenital subungual melanocytic nevus with a pseudo-Hutchinson sign"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "A&#46;M&#46; Goldminz"
                            1 => "D&#46; Wolpowitz"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Dermatol Online J"
                        "fecha" => "2013"
                        "volumen" => "19"
                        "paginaInicial" => "8"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/24021368"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            8 => array:3 [
              "identificador" => "bib0095"
              "etiqueta" => "9"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Patterns of nail matrix and bed of longitudinal melanonychia by intraoperative dermatoscopy"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "S&#46;H&#46; Hirata"
                            1 => "S&#46; Yamada"
                            2 => "M&#46;Y&#46; Enokihara"
                            3 => "N&#46; Di Chiacchio"
                            4 => "F&#46;A&#46; de Almeida"
                            5 => "M&#46;M&#46; Enokihara"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.jaad.2010.06.009"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Am Acad Dermatol"
                        "fecha" => "2011"
                        "volumen" => "65"
                        "paginaInicial" => "297"
                        "paginaFinal" => "303"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/21531039"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            9 => array:3 [
              "identificador" => "bib0100"
              "etiqueta" => "10"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "In situ melanoma of the nail unit in children&#58; Report of two cases in fair-skinned Caucasian children"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "A&#46; Tosti"
                            1 => "B&#46; Piraccini"
                            2 => "A&#46; Cagalli"
                            3 => "E&#46; Haneke"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1111/j.1525-1470.2011.01481.x"
                      "Revista" => array:6 [
                        "tituloSerie" => "Pediatr Dermatol"
                        "fecha" => "2012"
                        "volumen" => "29"
                        "paginaInicial" => "79"
                        "paginaFinal" => "83"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/21575049"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
          ]
        ]
      ]
    ]
  ]
  "idiomaDefecto" => "en"
  "url" => "/15782190/0000010900000006/v1_201808010420/S1578219018301719/v1_201808010420/en/main.assets"
  "Apartado" => array:4 [
    "identificador" => "6157"
    "tipo" => "SECCION"
    "en" => array:2 [
      "titulo" => "Case and Research Letters"
      "idiomaDefecto" => true
    ]
    "idiomaDefecto" => "en"
  ]
  "PDF" => "https://static.elsevier.es/multimedia/15782190/0000010900000006/v1_201808010420/S1578219018301719/v1_201808010420/en/main.pdf?idApp=UINPBA000044&text.app=https://actasdermo.org/"
  "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1578219018301719?idApp=UINPBA000044"
]
Información del artículo
ISSN: 15782190
Idioma original: Inglés
Datos actualizados diariamente
año/Mes Html Pdf Total
2024 Noviembre 178 10 188
2024 Octubre 1266 61 1327
2024 Septiembre 1144 65 1209
2024 Agosto 1117 85 1202
2024 Julio 1190 88 1278
2024 Junio 756 63 819
2024 Mayo 680 59 739
2024 Abril 649 56 705
2024 Marzo 788 44 832
2024 Febrero 830 44 874
2024 Enero 1172 48 1220
2023 Diciembre 1018 27 1045
2023 Noviembre 928 52 980
2023 Octubre 1025 46 1071
2023 Septiembre 936 40 976
2023 Agosto 609 31 640
2023 Julio 451 43 494
2023 Junio 521 31 552
2023 Mayo 692 38 730
2023 Abril 575 28 603
2023 Marzo 456 40 496
2023 Febrero 410 25 435
2023 Enero 425 24 449
2022 Diciembre 325 54 379
2022 Noviembre 318 23 341
2022 Octubre 298 27 325
2022 Septiembre 337 46 383
2022 Agosto 302 54 356
2022 Julio 267 45 312
2022 Junio 251 30 281
2022 Mayo 819 51 870
2022 Abril 993 58 1051
2022 Marzo 1153 64 1217
2022 Febrero 739 31 770
2022 Enero 953 48 1001
2021 Diciembre 818 58 876
2021 Noviembre 805 65 870
2021 Octubre 1091 97 1188
2021 Septiembre 910 57 967
2021 Agosto 1224 66 1290
2021 Julio 1274 42 1316
2021 Junio 1343 53 1396
2021 Mayo 1404 77 1481
2021 Abril 2466 106 2572
2021 Marzo 1610 51 1661
2021 Febrero 1202 43 1245
2021 Enero 1186 39 1225
2020 Diciembre 1154 38 1192
2020 Noviembre 1115 24 1139
2020 Octubre 824 25 849
2020 Septiembre 861 33 894
2020 Agosto 552 22 574
2020 Julio 368 22 390
2020 Junio 180 30 210
2020 Mayo 96 27 123
2020 Abril 40 17 57
2020 Marzo 10 10 20
2020 Febrero 1 0 1
2019 Mayo 0 1 1
Mostrar todo

Siga este enlace para acceder al texto completo del artículo

Idiomas
Actas Dermo-Sifiliográficas
es en

¿Es usted profesional sanitario apto para prescribir o dispensar medicamentos?

Are you a health professional able to prescribe or dispense drugs?