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with areas of fluid collection&#44; together with intense vascularization on Doppler mode &#40;<a class="elsevierStyleCrossRef" href="#fig0010">Fig&#46; 2</a>&#41;&#46; Given the location and depth of the lesion&#44; the patient was sent to the clinic of the surgery department for complete removal of the lesion&#46; Histopathology showed changes that were compatible with HS and well-differentiated squamous cell carcinoma &#40;SCC&#41; over the fistulous tract&#44; which was located close to the deep resection margin&#46; No vascular invasion or perineural infiltration was observed &#40;<a class="elsevierStyleCrossRef" href="#fig0015">Fig&#46; 3</a> A and B&#41;&#46; Extension of the surgical margins revealed no evidence of residual tumor&#44; although foci suggestive of viral infection were observed &#40;<a class="elsevierStyleCrossRef" href="#fig0015">Fig&#46; 3</a>C&#41;&#46; Immunohistochemical staining with p16 was intensely positive &#40;<a class="elsevierStyleCrossRef" href="#fig0015">Fig&#46; 3</a>D&#41;&#46; Polymerase chain reaction and genotyping based on in situ hybridization with a microarray of paraffin-embedded tissue were performed to investigate the presence of human papillomavirus &#40;HPV&#41;&#46; The result was positive for genotype 6 &#40;considered low risk&#41;&#59; the same finding was recorded for the perianal condylomata acuminata&#46; Laboratory analysis yielded negative results for HIV and hepatotropic viruses&#46; After a 12-month clinical and imaging-based follow-up &#40;computed tomography and magnetic resonance imaging of the pelvis&#41;&#44; the patient showed no signs of local recurrence or metastasis&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><elsevierMultimedia ident="fig0010"></elsevierMultimedia><elsevierMultimedia ident="fig0015"></elsevierMultimedia><p id="par0010" class="elsevierStylePara elsevierViewall">During the last few decades&#44; there have been reports of cases of carcinomatous transformation in HS in the perineal&#44; perianal&#44; and gluteal region&#46; Of particular interest is the review of Lagoviez et al&#46;&#44;<a class="elsevierStyleCrossRef" href="#bib0055"><span class="elsevierStyleSup">1</span></a> who report 13 new cases and investigate the presence of HPV in 8 histology samples&#46; According to the literature&#44; the condition predominantly affects men&#46; This observation is logical&#44; given that the locations of HS reported above are typical in men&#46;<a class="elsevierStyleCrossRef" href="#bib0060"><span class="elsevierStyleSup">2</span></a></p><p id="par0015" class="elsevierStylePara elsevierViewall">A key question in this disease at present is whether malignant degeneration occurs more frequently in the perianal or gluteal region owing to HPV infection in these areas&#46; The virus seems to be implicated in the pathogenesis of SCC through oncogenic expression&#46;<a class="elsevierStyleCrossRef" href="#bib0065"><span class="elsevierStyleSup">3</span></a> This has also been reported in the development of other types of intraepithelial neoplasia and tumors in the anogenital region&#44; affecting the penis&#44; scrotum&#44; and anal&#44; vulvar&#44; and vaginal areas&#46;<a class="elsevierStyleCrossRefs" href="#bib0070"><span class="elsevierStyleSup">4&#44;5</span></a> Twenty years ago&#44; Li et al&#46;<a class="elsevierStyleCrossRef" href="#bib0080"><span class="elsevierStyleSup">6</span></a> first put forward the hypothesis that HPV played an important role in the SCC that arises in HS&#44; although they did not perform a histopathology analysis&#46;<a class="elsevierStyleCrossRef" href="#bib0080"><span class="elsevierStyleSup">6</span></a> However&#44; in a later study&#44; Lagoviez et al&#46;<a class="elsevierStyleCrossRef" href="#bib0055"><span class="elsevierStyleSup">1</span></a> investigated the presence of HPV in 8 anogenital tumors using polymerase chain reaction&#46; The results were positive in all 8 samples&#44; both for the low-risk genotypes &#40;HPV-6&#41; and for the high-risk genotypes &#40;HPV-16 and 68&#41;&#46; It was recently demonstrated that even HPV genotypes that are low-risk may be involved per se in the development of anogenital SCC&#46;<a class="elsevierStyleCrossRef" href="#bib0085"><span class="elsevierStyleSup">7</span></a></p><p id="par0020" class="elsevierStylePara elsevierViewall">Flores et al&#46;<a class="elsevierStyleCrossRef" href="#bib0090"><span class="elsevierStyleSup">8</span></a> observed a significant positive correlation in HPV-16 viral load between nearby sites of infection&#44; such as the anal canal and the perianal area or the perianal area and the scrotum&#44; or sites that are in regular contact in a resting position&#46; Therefore&#44; previously uninfected genital areas could become inoculated by infections at nearby anatomical sites through direct contact and facilitated by environmental factors such as humidity&#44; temperature&#44; and&#44; possibly&#44; poor hygiene&#46;</p><p id="par0025" class="elsevierStylePara elsevierViewall">Furthermore&#44; the advent of anti&#8211;tumor necrosis factor therapy in HS has led various authors to recommend investigating the presence of lesions suggestive of HPV in these areas&#44; since there have even been reports of deaths resulting from the development of SCC after initiation of this therapy&#46;<a class="elsevierStyleCrossRefs" href="#bib0055"><span class="elsevierStyleSup">1&#44;9</span></a></p><p id="par0030" class="elsevierStylePara elsevierViewall">Both ultrasound and magnetic resonance imaging could prove useful for confirmation of the true anatomical extension of the disease before surgery&#46;<a class="elsevierStyleCrossRef" href="#bib0100"><span class="elsevierStyleSup">10</span></a> Wide excision of the lesion is considered the standard treatment&#46; SCC that arises in areas of chronic inflammation caused by HS is often well differentiated&#46; Nevertheless&#44; despite this theoretically good histologic prognosis&#44; we can observe rapid growth&#44; local aggressiveness&#44; early metastasis&#44; and high mortality&#46;<a class="elsevierStyleCrossRef" href="#bib0055"><span class="elsevierStyleSup">1</span></a></p><p id="par0035" class="elsevierStylePara elsevierViewall">The case we report supports the relevant role of HPV in the development of SCC in patients with HS in the inguinal&#44; perineal&#44; and perianal areas&#46;</p><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0005">Conflicts of Interest</span><p id="par0040" class="elsevierStylePara elsevierViewall">The authors declare that they have no conflicts of interest&#46;</p></span></span>"
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Case and Research Letters
Human Papilloma Virus and the Risk of Squamous Cell Carcinoma Arising in Hidradenitis Suppurativa
Virus del papiloma humano y riesgo de desarrollo de carcinoma escamocelular en la hidradenitis supurativa
J.M. Segura Palaciosa,
Autor para correspondencia
juanmanuelo_1983@hotmail.com

Corresponding author.
, P. García Monteroa, R. Fúnez Liébanab, J.B. Repiso Jiméneza
a Servicio de Dermatología, Hospital Costa del Sol, Marbella, Málaga, España
b Servicio de Anatomía Patológica, Hospital Costa del Sol, Marbella, Málaga, España
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with areas of fluid collection&#44; together with intense vascularization on Doppler mode &#40;<a class="elsevierStyleCrossRef" href="#fig0010">Fig&#46; 2</a>&#41;&#46; Given the location and depth of the lesion&#44; the patient was sent to the clinic of the surgery department for complete removal of the lesion&#46; Histopathology showed changes that were compatible with HS and well-differentiated squamous cell carcinoma &#40;SCC&#41; over the fistulous tract&#44; which was located close to the deep resection margin&#46; No vascular invasion or perineural infiltration was observed &#40;<a class="elsevierStyleCrossRef" href="#fig0015">Fig&#46; 3</a> A and B&#41;&#46; Extension of the surgical margins revealed no evidence of residual tumor&#44; although foci suggestive of viral infection were observed &#40;<a class="elsevierStyleCrossRef" href="#fig0015">Fig&#46; 3</a>C&#41;&#46; Immunohistochemical staining with p16 was intensely positive &#40;<a class="elsevierStyleCrossRef" href="#fig0015">Fig&#46; 3</a>D&#41;&#46; Polymerase chain reaction and genotyping based on in situ hybridization with a microarray of paraffin-embedded tissue were performed to investigate the presence of human papillomavirus &#40;HPV&#41;&#46; The result was positive for genotype 6 &#40;considered low risk&#41;&#59; the same finding was recorded for the perianal condylomata acuminata&#46; Laboratory analysis yielded negative results for HIV and hepatotropic viruses&#46; After a 12-month clinical and imaging-based follow-up &#40;computed tomography and magnetic resonance imaging of the pelvis&#41;&#44; the patient showed no signs of local recurrence or metastasis&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><elsevierMultimedia ident="fig0010"></elsevierMultimedia><elsevierMultimedia ident="fig0015"></elsevierMultimedia><p id="par0010" class="elsevierStylePara elsevierViewall">During the last few decades&#44; there have been reports of cases of carcinomatous transformation in HS in the perineal&#44; perianal&#44; and gluteal region&#46; Of particular interest is the review of Lagoviez et al&#46;&#44;<a class="elsevierStyleCrossRef" href="#bib0055"><span class="elsevierStyleSup">1</span></a> who report 13 new cases and investigate the presence of HPV in 8 histology samples&#46; According to the literature&#44; the condition predominantly affects men&#46; This observation is logical&#44; given that the locations of HS reported above are typical in men&#46;<a class="elsevierStyleCrossRef" href="#bib0060"><span class="elsevierStyleSup">2</span></a></p><p id="par0015" class="elsevierStylePara elsevierViewall">A key question in this disease at present is whether malignant degeneration occurs more frequently in the perianal or gluteal region owing to HPV infection in these areas&#46; The virus seems to be implicated in the pathogenesis of SCC through oncogenic expression&#46;<a class="elsevierStyleCrossRef" href="#bib0065"><span class="elsevierStyleSup">3</span></a> This has also been reported in the development of other types of intraepithelial neoplasia and tumors in the anogenital region&#44; affecting the penis&#44; scrotum&#44; and anal&#44; vulvar&#44; and vaginal areas&#46;<a class="elsevierStyleCrossRefs" href="#bib0070"><span class="elsevierStyleSup">4&#44;5</span></a> Twenty years ago&#44; Li et al&#46;<a class="elsevierStyleCrossRef" href="#bib0080"><span class="elsevierStyleSup">6</span></a> first put forward the hypothesis that HPV played an important role in the SCC that arises in HS&#44; although they did not perform a histopathology analysis&#46;<a class="elsevierStyleCrossRef" href="#bib0080"><span class="elsevierStyleSup">6</span></a> However&#44; in a later study&#44; Lagoviez et al&#46;<a class="elsevierStyleCrossRef" href="#bib0055"><span class="elsevierStyleSup">1</span></a> investigated the presence of HPV in 8 anogenital tumors using polymerase chain reaction&#46; The results were positive in all 8 samples&#44; both for the low-risk genotypes &#40;HPV-6&#41; and for the high-risk genotypes &#40;HPV-16 and 68&#41;&#46; It was recently demonstrated that even HPV genotypes that are low-risk may be involved per se in the development of anogenital SCC&#46;<a class="elsevierStyleCrossRef" href="#bib0085"><span class="elsevierStyleSup">7</span></a></p><p id="par0020" class="elsevierStylePara elsevierViewall">Flores et al&#46;<a class="elsevierStyleCrossRef" href="#bib0090"><span class="elsevierStyleSup">8</span></a> observed a significant positive correlation in HPV-16 viral load between nearby sites of infection&#44; such as the anal canal and the perianal area or the perianal area and the scrotum&#44; or sites that are in regular contact in a resting position&#46; Therefore&#44; previously uninfected genital areas could become inoculated by infections at nearby anatomical sites through direct contact and facilitated by environmental factors such as humidity&#44; temperature&#44; and&#44; possibly&#44; poor hygiene&#46;</p><p id="par0025" class="elsevierStylePara elsevierViewall">Furthermore&#44; the advent of anti&#8211;tumor necrosis factor therapy in HS has led various authors to recommend investigating the presence of lesions suggestive of HPV in these areas&#44; since there have even been reports of deaths resulting from the development of SCC after initiation of this therapy&#46;<a class="elsevierStyleCrossRefs" href="#bib0055"><span class="elsevierStyleSup">1&#44;9</span></a></p><p id="par0030" class="elsevierStylePara elsevierViewall">Both ultrasound and magnetic resonance imaging could prove useful for confirmation of the true anatomical extension of the disease before surgery&#46;<a class="elsevierStyleCrossRef" href="#bib0100"><span class="elsevierStyleSup">10</span></a> Wide excision of the lesion is considered the standard treatment&#46; SCC that arises in areas of chronic inflammation caused by HS is often well differentiated&#46; Nevertheless&#44; despite this theoretically good histologic prognosis&#44; we can observe rapid growth&#44; local aggressiveness&#44; early metastasis&#44; and high mortality&#46;<a class="elsevierStyleCrossRef" href="#bib0055"><span class="elsevierStyleSup">1</span></a></p><p id="par0035" class="elsevierStylePara elsevierViewall">The case we report supports the relevant role of HPV in the development of SCC in patients with HS in the inguinal&#44; perineal&#44; and perianal areas&#46;</p><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0005">Conflicts of Interest</span><p id="par0040" class="elsevierStylePara elsevierViewall">The authors declare that they have no conflicts of interest&#46;</p></span></span>"
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          "en" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">A&#44; B mode&#44; 18-MHz probe&#46; The presence of a fistulous tract in the subcutaneous cellular tissue and a fluid collection area can be observed&#46; B&#44; Doppler study showing intense vascularization inside the fistulous tract&#46;</p>"
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          "en" => "<p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">A&#44; Well-differentiated squamous cell carcinoma covering the fistulous tract&#46; B&#44; Expansive growth pattern of squamous cell carcinoma in greater detail&#46; C&#44; Areas with a koilocytic appearance&#46; D&#44; Extensive nuclear and cytoplasmic positivity to p16&#46;</p>"
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