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array:24 [ "pii" => "S1578219018300647" "issn" => "15782190" "doi" => "10.1016/j.adengl.2017.07.016" "estado" => "S300" "fechaPublicacion" => "2018-07-01" "aid" => "1838" "copyright" => "Elsevier España, S.L.U. and AEDV" "copyrightAnyo" => "2017" "documento" => "simple-article" "crossmark" => 1 "subdocumento" => "crp" "cita" => "Actas Dermosifiliogr. 2018;109:559-60" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:2 [ "total" => 6 "formatos" => array:2 [ "HTML" => 4 "PDF" => 2 ] ] "Traduccion" => array:1 [ "es" => array:19 [ "pii" => "S000173101730594X" "issn" => "00017310" "doi" => "10.1016/j.ad.2017.07.021" "estado" => "S300" "fechaPublicacion" => "2018-07-01" "aid" => "1838" "copyright" => "AEDV" "documento" => "simple-article" "crossmark" => 1 "subdocumento" => "crp" "cita" => "Actas Dermosifiliogr. 2018;109:559-60" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:2 [ "total" => 69 "formatos" => array:2 [ "HTML" => 42 "PDF" => 27 ] ] "es" => array:11 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">CARTA CIENTÍFICO-CLÍNICA</span>" "titulo" => "Un caso de poroqueratosis diseminada eruptiva en un paciente oncológico tratado con trastuzumab y exemestano: ¿fenómeno asociado al cáncer o inducido por fármacos?" "tienePdf" => "es" "tieneTextoCompleto" => "es" "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "559" "paginaFinal" => "560" ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "A Case of Eruptive Disseminated Porokeratosis in a Cancer Patient after Trastuzumab and Exemestane Treatment: Cancer Related or Drug Induced Phenomenon?" ] ] "contieneTextoCompleto" => array:1 [ "es" => true ] "contienePdf" => array:1 [ "es" => true ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0005" "etiqueta" => "Figura 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 563 "Ancho" => 750 "Tamanyo" => 53594 ] ] "descripcion" => array:1 [ "es" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Máculas ovaladas de color marrón-grisáceo, levemente palpables, bien delimitadas, de entre 2 y 5<span class="elsevierStyleHsp" style=""></span>mm de diámetro, muchas de ellas con correlatos de escamas.</p>" ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "C. 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"apellidos" => "Blum" ] ] ] ] ] "idiomaDefecto" => "es" "Traduccion" => array:1 [ "en" => array:9 [ "pii" => "S1578219018300647" "doi" => "10.1016/j.adengl.2017.07.016" "estado" => "S300" "subdocumento" => "" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1578219018300647?idApp=UINPBA000044" ] ] "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S000173101730594X?idApp=UINPBA000044" "url" => "/00017310/0000010900000006/v1_201808010427/S000173101730594X/v1_201808010427/es/main.assets" ] ] "itemSiguiente" => array:19 [ "pii" => "S1578219018301598" "issn" => "15782190" "doi" => "10.1016/j.adengl.2018.05.002" "estado" => "S300" "fechaPublicacion" => "2018-07-01" "aid" => "1837" "copyright" => "Elsevier España, S.L.U. and AEDV" "documento" => "simple-article" "crossmark" => 1 "subdocumento" => "crp" "cita" => "Actas Dermosifiliogr. 2018;109:560-2" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:2 [ "total" => 4 "formatos" => array:3 [ "EPUB" => 1 "HTML" => 2 "PDF" => 1 ] ] "en" => array:11 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Case and Research Letters</span>" "titulo" => "Expanding the genetic profile of Hay-Wells syndrome" "tienePdf" => "en" "tieneTextoCompleto" => "en" "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "560" "paginaFinal" => "562" ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Ampliando el perfil genético del síndrome de Hay-Wells" ] ] "contieneTextoCompleto" => array:1 [ "en" => true ] "contienePdf" => array:1 [ "en" => true ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0005" "etiqueta" => "Figure 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 1173 "Ancho" => 900 "Tamanyo" => 121135 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">The patient presented congenital wiry, sparse, pale hair on the scalp, eyebrows and eyelids, due to ectodermal dysplasia.</p>" ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "D. Romero-Pérez, B. Encabo-Durán, R. Ramón-Sapena" "autores" => array:3 [ 0 => array:2 [ "nombre" => "D." "apellidos" => "Romero-Pérez" ] 1 => array:2 [ "nombre" => "B." "apellidos" => "Encabo-Durán" ] 2 => array:2 [ "nombre" => "R." "apellidos" => "Ramón-Sapena" ] ] ] ] ] "idiomaDefecto" => "en" "Traduccion" => array:1 [ "es" => array:9 [ "pii" => "S0001731017305938" "doi" => "10.1016/j.ad.2017.09.013" "estado" => "S300" "subdocumento" => "" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0001731017305938?idApp=UINPBA000044" ] ] "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1578219018301598?idApp=UINPBA000044" "url" => "/15782190/0000010900000006/v1_201808010420/S1578219018301598/v1_201808010420/en/main.assets" ] "itemAnterior" => array:19 [ "pii" => "S1578219018301604" "issn" => "15782190" "doi" => "10.1016/j.adengl.2018.05.003" "estado" => "S300" "fechaPublicacion" => "2018-07-01" "aid" => "1840" "copyright" => "Elsevier España, S.L.U. and AEDV" "documento" => "simple-article" "crossmark" => 1 "subdocumento" => "crp" "cita" => "Actas Dermosifiliogr. 2018;109:557-8" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "en" => array:11 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Case and Research Letters</span>" "titulo" => "Post-Implantation Erythema Associated to a Breast Implant Treated With Pulsed-Dye Laser" "tienePdf" => "en" "tieneTextoCompleto" => "en" "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "557" "paginaFinal" => "558" ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Eritema postimplantación asociado a implante mamario tratado con láser de colorante pulsado" ] ] "contieneTextoCompleto" => array:1 [ "en" => true ] "contienePdf" => array:1 [ "en" => true ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0005" "etiqueta" => "Figure 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 762 "Ancho" => 1733 "Tamanyo" => 89364 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Clinical presentation. (1) Before pulsed-dye laser treatment. Erythema with telangiectasias associated over the lower half of the right breast. (2) 3 months after pulsed-dye laser. A significant clearance of the erythema can be observed, although a mild hyperpigmentation was associated due to the treatment.</p>" ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "A. Alegre-Sánchez, D. Buendía-Castaño, P. Fernández-González, B. Pérez-García" "autores" => array:4 [ 0 => array:2 [ "nombre" => "A." "apellidos" => "Alegre-Sánchez" ] 1 => array:2 [ "nombre" => "D." "apellidos" => "Buendía-Castaño" ] 2 => array:2 [ "nombre" => "P." "apellidos" => "Fernández-González" ] 3 => array:2 [ "nombre" => "B." "apellidos" => "Pérez-García" ] ] ] ] ] "idiomaDefecto" => "en" "Traduccion" => array:1 [ "es" => array:9 [ "pii" => "S0001731017305963" "doi" => "10.1016/j.ad.2017.09.015" "estado" => "S300" "subdocumento" => "" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0001731017305963?idApp=UINPBA000044" ] ] "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1578219018301604?idApp=UINPBA000044" "url" => "/15782190/0000010900000006/v1_201808010420/S1578219018301604/v1_201808010420/en/main.assets" ] "en" => array:15 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Case and Research Letters</span>" "titulo" => "A Case of Eruptive Disseminated Porokeratosis in a Cancer Patient after Trastuzumab and Exemestane Treatment: Cancer Related or Drug Induced Phenomenon?" "tieneTextoCompleto" => true "saludo" => "<span class="elsevierStyleItalic">To the editor:</span>" "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "559" "paginaFinal" => "560" ] ] "autores" => array:1 [ 0 => array:4 [ "autoresLista" => "C. Mangas, V. Espeli, R. Blum" "autores" => array:3 [ 0 => array:4 [ "nombre" => "C." "apellidos" => "Mangas" "email" => array:2 [ 0 => "cris_mangas@yahoo.es" 1 => "cristina.mangas@eoc.ch" ] "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">*</span>" "identificador" => "cor0005" ] ] ] 1 => array:3 [ "nombre" => "V." "apellidos" => "Espeli" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] ] ] 2 => array:3 [ "nombre" => "R." "apellidos" => "Blum" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">c</span>" "identificador" => "aff0015" ] ] ] ] "afiliaciones" => array:3 [ 0 => array:3 [ "entidad" => "Unidad de Dermatología, Hospital Regional de Bellinzona e Valli, Bellinzona, Suiza" "etiqueta" => "a" "identificador" => "aff0005" ] 1 => array:3 [ "entidad" => "Oncology Institute of Italian Switzerland (IOSI), Bellinzona, Suiza" "etiqueta" => "b" "identificador" => "aff0010" ] 2 => array:3 [ "entidad" => "Unidad de Dermatología, Inselspital, Hospital Universitario de Berna, Berna, Suiza" "etiqueta" => "c" "identificador" => "aff0015" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "⁎" "correspondencia" => "Corresponding author." ] ] ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Un caso de poroqueratosis diseminada eruptiva en un paciente oncológico tratado con trastuzumab y exemestano: ¿fenómeno asociado al cáncer o inducido por fármacos?" ] ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0010" "etiqueta" => "Figure 2" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr2.jpeg" "Alto" => 638 "Ancho" => 850 "Tamanyo" => 166186 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Histopathology (hematoxylin and eosin; magnification 10x) shows the typical pattern of porokeratosis with central column of parakeratosis (cornoid lamella) and dyskeratotic keratinocytes.</p>" ] ] ] "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">We report a rare skin toxicity in a 62-years-old white female with a history of an estrogen receptor- and progesterone receptor–positive (95% and 50% of tumor cells, respectively) human epidermal growth factor receptor 2 (HER2)–positive invasive ductal carcinoma of the left breast (initial stage pT2 pN1a M0). She underwent radical modified mastectomy plus axillary node dissection followed by adjuvant treatment with 1 year of trastuzumab and 5 years of the aromatase inhibitor letrozole. Six years after the diagnosis, the patient developed bone and internal mammary lymph node metastases treated with exemestane and trastuzumab. Two months after starting treatment, she developed non-painful but slightly itching diffuse skin lesions. She showed multiple, disseminated, brown-grey oval macules, slightly palpable, well delimitated, 2-5<span class="elsevierStyleHsp" style=""></span>mm in diameter, many with collarettes of scale. Lesions were located in both sun-exposed and non-sun-exposed sites, predominantly in the back, trunk and upper extremities (<a class="elsevierStyleCrossRef" href="#fig0005">Figure 1</a>). The biopsy of a back lesion revealed a focal thinning of the epidermis, with loss of the granular layer and a discrete column of parakeratosis (<a class="elsevierStyleCrossRef" href="#fig0010">Figure 2</a>). Symptomatic treatment with topical bethametason and salicyl acid was initiated with resolution of pruritus. Patient did not accept the proposed systemic treatment with Acitretinon nor Tacalcitol oinment. The patient is still receiving the combined therapy after achieving a complete disease remission and macules persist unchanged without dose reductions or lengthening of treatment intervals. No new skin adverse reactions were observed.</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><elsevierMultimedia ident="fig0010"></elsevierMultimedia><p id="par0010" class="elsevierStylePara elsevierViewall">Trastuzumab is a monoclonal antibody that binds to the extracellular domain of HER2 and exemestane is an aromatase inhibitor which suppresses plasma oestrogen levels by inhibition of the enzyme aromatase. Acne vulgaris, nail changes, pruritus, leukopenia and more rarely cellulitis, dermal ulcer and erysipela have been described under trastuzumab treatment. Alopecia, dermatitis, itching, acute generalized exanthematous pustulosis, pruritus and urticaria were reported for exemestane.<a class="elsevierStyleCrossRef" href="#bib0040"><span class="elsevierStyleSup">1</span></a></p><p id="par0015" class="elsevierStylePara elsevierViewall">Porokeratosis is a heterogeneous group of hereditary or acquired disorders of keratinization believed to arise from an expansion of abnormal keratinocytes. Multiple variants of porokeratosis have been described.<a class="elsevierStyleCrossRefs" href="#bib0045"><span class="elsevierStyleSup">2,3</span></a> Recently, a new entity named Eruptive porokeratosis has been reported to describe cases of acute, disseminated eruptions.<a class="elsevierStyleCrossRef" href="#bib0050"><span class="elsevierStyleSup">3</span></a> Pathogenesis is not well understood. Some proposed triggering factors include genetics, ultraviolet light exposure, infection, and immunosuppression (ie,transplant recipients, retroviral disease).<a class="elsevierStyleCrossRefs" href="#bib0045"><span class="elsevierStyleSup">2,4–6</span></a> Some reports of drug-induced cases are also reported, mainly due to immunosuppressing drugs (ie, prednisone, antirheumatic drugs, biologics).<a class="elsevierStyleCrossRefs" href="#bib0050"><span class="elsevierStyleSup">3–5</span></a> Some authors speculate that porokeratosis, specially the eruptive form, may represent a paraneoplastic manifestation since it has been described in association with hematopoietic malignancies orsolid organ tumors (ie, hepatocellular carcinoma, cholangiocarcinoma, ovarian cancer).<a class="elsevierStyleCrossRefs" href="#bib0050"><span class="elsevierStyleSup">3–7</span></a> The typical histological feature of porokeratosis is the cornoid lamella, which corresponds to the border between normal epidermis and the clone of mutant keratinocytes. Prognosis of porokeratosis is generally good but some cases of squamos cell carcinoma developed on porokeratosis have been described, suggesting porokeratosis as a possible pre-cancer situation. Proposed treatments are photodinamic therapy, local tacalcitol or Acitretinoin for disseminated variants.<a class="elsevierStyleCrossRefs" href="#bib0045"><span class="elsevierStyleSup">2,3</span></a></p><p id="par0020" class="elsevierStylePara elsevierViewall">No data have been reported so far about the link between porokeratosis and exemestane or trastuzumab. As the patient is still receiving the same oncological treatment, persistence of the lesions could be linked with either the immunotherapy or the antihormonal therapy. Porokeratosis is a disorder of keratinization and antibodies targeting the HER-family receptors can cause disorders at this level The possibility that eruptive porokeratosis must be considered as a paraneoplastic phenomenon in our case cannot be completely ruled out. Nevertheless, the long period of time between both conditions, the fact that skin eruption persists although tumor response to the treatment and a time association with the treatment starting supports a drug induced phenomenon in our opinion.</p></span>" "pdfFichero" => "main.pdf" "tienePdf" => true "NotaPie" => array:1 [ 0 => array:2 [ "etiqueta" => "☆" "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Please cite this article as: Mangas C, Espeli V, Blum R. Un caso de poroqueratosis diseminada eruptiva en un paciente oncológico tratado con trastuzumab y exemestano: ¿fenómeno asociado al cáncer o inducido por fármacos?. Actas Dermosifiliogr. 2018;109:559–560.</p>" ] ] "multimedia" => array:2 [ 0 => array:7 [ "identificador" => "fig0005" "etiqueta" => "Figure 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 525 "Ancho" => 700 "Tamanyo" => 47498 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Brown-grey oval macules, slightly palpable, well delimitated, 2-to-5<span class="elsevierStyleHsp" style=""></span>mm in diameter, many with collarettes of scale.</p>" ] ] 1 => array:7 [ "identificador" => "fig0010" "etiqueta" => "Figure 2" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr2.jpeg" "Alto" => 638 "Ancho" => 850 "Tamanyo" => 166186 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Histopathology (hematoxylin and eosin; magnification 10x) shows the typical pattern of porokeratosis with central column of parakeratosis (cornoid lamella) and dyskeratotic keratinocytes.</p>" ] ] ] "bibliografia" => array:2 [ "titulo" => "Références" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0015" "bibliografiaReferencia" => array:7 [ 0 => array:3 [ "identificador" => "bib0040" "etiqueta" => "1" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Cutaneous adverse effects of targeted therapies: Part II: Inhibitors of intracellular molecular signaling pathways" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "J.B. 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año/Mes | Html | Total | |
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2024 Noviembre | 8 | 7 | 15 |
2024 Octubre | 81 | 53 | 134 |
2024 Septiembre | 81 | 25 | 106 |
2024 Agosto | 96 | 70 | 166 |
2024 Julio | 94 | 38 | 132 |
2024 Junio | 97 | 42 | 139 |
2024 Mayo | 78 | 46 | 124 |
2024 Abril | 79 | 42 | 121 |
2024 Marzo | 78 | 24 | 102 |
2024 Febrero | 62 | 28 | 90 |
2024 Enero | 64 | 38 | 102 |
2023 Diciembre | 65 | 17 | 82 |
2023 Noviembre | 92 | 28 | 120 |
2023 Octubre | 73 | 25 | 98 |
2023 Septiembre | 66 | 33 | 99 |
2023 Agosto | 55 | 17 | 72 |
2023 Julio | 90 | 37 | 127 |
2023 Junio | 66 | 24 | 90 |
2023 Mayo | 76 | 21 | 97 |
2023 Abril | 38 | 23 | 61 |
2023 Marzo | 71 | 27 | 98 |
2023 Febrero | 52 | 30 | 82 |
2023 Enero | 69 | 31 | 100 |
2022 Diciembre | 66 | 58 | 124 |
2022 Noviembre | 48 | 28 | 76 |
2022 Octubre | 53 | 27 | 80 |
2022 Septiembre | 44 | 44 | 88 |
2022 Agosto | 63 | 38 | 101 |
2022 Julio | 49 | 29 | 78 |
2022 Junio | 42 | 30 | 72 |
2022 Mayo | 37 | 31 | 68 |
2022 Abril | 39 | 32 | 71 |
2022 Marzo | 39 | 35 | 74 |
2022 Febrero | 44 | 36 | 80 |
2022 Enero | 37 | 40 | 77 |
2021 Diciembre | 40 | 60 | 100 |
2021 Noviembre | 54 | 43 | 97 |
2021 Octubre | 40 | 49 | 89 |
2021 Septiembre | 44 | 42 | 86 |
2021 Agosto | 33 | 37 | 70 |
2021 Julio | 37 | 28 | 65 |
2021 Junio | 31 | 34 | 65 |
2021 Mayo | 30 | 45 | 75 |
2021 Abril | 94 | 92 | 186 |
2021 Marzo | 46 | 49 | 95 |
2021 Febrero | 62 | 35 | 97 |
2021 Enero | 48 | 22 | 70 |
2020 Diciembre | 35 | 25 | 60 |
2020 Noviembre | 26 | 23 | 49 |
2020 Octubre | 25 | 13 | 38 |
2020 Septiembre | 25 | 20 | 45 |
2020 Agosto | 34 | 25 | 59 |
2020 Julio | 33 | 21 | 54 |
2020 Junio | 32 | 37 | 69 |
2020 Mayo | 33 | 22 | 55 |
2020 Abril | 23 | 24 | 47 |
2020 Marzo | 17 | 15 | 32 |
2020 Febrero | 2 | 0 | 2 |
2018 Diciembre | 4 | 2 | 6 |