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        "titulo" => "Riesgo de fotocarcinog&#233;nesis asociado a la fototerapia UVB-BE&#46; Estudio epidemiol&#243;gico de un hospital terciario"
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          "en" => "<p id="spar0045" class="elsevierStyleSimplePara elsevierViewall">Location of skin cancer in study patients treated with NB UV-B phototherapy&#46; Basal cell carcinoma is shown in blue and squamous cell carcinoma in red&#46;</p>"
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    "textoCompleto" => "<span class="elsevierStyleSections"><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0065">Introduction</span><p id="par0005" class="elsevierStylePara elsevierViewall">Phototherapy is a physical treatment modality based on ultraviolet light that is widely used in dermatology&#46; The most widely used modality today is narrowband &#40;NB&#41; UV-B phototherapy&#44; owing to its safety and convenience&#46;<a class="elsevierStyleCrossRef" href="#bib0090"><span class="elsevierStyleSup">1</span></a></p><p id="par0010" class="elsevierStylePara elsevierViewall">Despite being a relatively safe technique&#44; NB UV-B phototherapy causes concern&#44; mainly because of the hypothetical risk of nonmelanoma skin cancer &#40;NMSC&#41;&#46;</p><p id="par0015" class="elsevierStylePara elsevierViewall">The photocarcinogenic risk of other phototherapy modalities&#44; such as psoralen UV-A &#40;PUVA&#41;&#44; is well recognized&#46;<a class="elsevierStyleCrossRefs" href="#bib0095"><span class="elsevierStyleSup">2&#44;3</span></a> This risk has proven greater for cutaneous squamous cell carcinoma &#40;SCC&#41;&#44; especially on the lower limbs&#46;<a class="elsevierStyleCrossRef" href="#bib0105"><span class="elsevierStyleSup">4</span></a></p><p id="par0020" class="elsevierStylePara elsevierViewall">Experimental studies have shown the carcinogenic effects of broadband UV-B phototherapy&#46; NB UV-B has proven to be more carcinogenic than broadband UV-B in animals&#46;<a class="elsevierStyleCrossRefs" href="#bib0110"><span class="elsevierStyleSup">5&#44;6</span></a> Nevertheless&#44; no clinical practice&#8211;based study has managed to demonstrate an increased risk of NMSC or melanoma associated with NB UV-B phototherapy&#46;<a class="elsevierStyleCrossRef" href="#bib0095"><span class="elsevierStyleSup">2</span></a></p><p id="par0025" class="elsevierStylePara elsevierViewall">The incidence of NMSC varies considerably according to several factors &#40;eg&#44; geographic region&#44; skin phototype&#44; and sun exposure habits&#41;&#46; Therefore&#44; caution should be exercised when extrapolating the findings of epidemiological studies on NMSC performed in specific geographical regions to other populations&#46; In the case of the Spanish population&#44; several studies have determined the incidence of NMSC in populations from different geographic areas&#46;<a class="elsevierStyleCrossRef" href="#bib0120"><span class="elsevierStyleSup">7</span></a></p><p id="par0030" class="elsevierStylePara elsevierViewall">As for data on NMSC in patients treated with NB UV-B&#44; current studies in the Mediterranean area are scarce and heterogeneous and based on small samples&#46;<a class="elsevierStyleCrossRefs" href="#bib0125"><span class="elsevierStyleSup">8&#44;9</span></a></p><p id="par0035" class="elsevierStylePara elsevierViewall">Under the working hypothesis that NB UV-B phototherapy has a low or nonexistent risk of carcinogenesis&#44; the main objective of the present study was to determine the incidence of skin cancer in patients treated with NB UV-B phototherapy and to compare it with the incidence among the general population in a similar geographic area&#46;</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0070">Material and Methods</span><p id="par0040" class="elsevierStylePara elsevierViewall">We performed a retrospective observational study of 474 patients who had received full-body NB UV-B phototherapy between 2002 and 2016 at the Photobiology and Phototherapy Unit of Hospital General Universitario de Valencia &#40;HGUV&#41;&#44; Valencia&#44; Spain&#46;</p><p id="par0045" class="elsevierStylePara elsevierViewall">The inclusion and exclusion criteria are set out below&#46;</p><p id="par0050" class="elsevierStylePara elsevierViewall">Inclusion criteria<ul class="elsevierStyleList" id="lis0005"><li class="elsevierStyleListItem" id="lsti0005"><span class="elsevierStyleLabel">&#8226;</span><p id="par0055" class="elsevierStylePara elsevierViewall">Skin disease treated with NB UV-B phototherapy at the Photobiology and Phototherapy Unit of HGUV between 2002 and 2016&#46;</p></li><li class="elsevierStyleListItem" id="lsti0010"><span class="elsevierStyleLabel">&#8226;</span><p id="par0060" class="elsevierStylePara elsevierViewall">Data from at least 1 year of follow-up&#46;</p></li></ul></p><p id="par0065" class="elsevierStylePara elsevierViewall">Exclusion criteria<ul class="elsevierStyleList" id="lis0010"><li class="elsevierStyleListItem" id="lsti0015"><span class="elsevierStyleLabel">&#8226;</span><p id="par0070" class="elsevierStylePara elsevierViewall">Treatment with a phototherapy modality other than NB UV-B before treatment with NB UV-B or before the appearance of the first tumor&#46;</p></li></ul></p><p id="par0075" class="elsevierStylePara elsevierViewall">Patients received NB UV-B phototherapy using the Waldmann UV-7002 or Waldmann UV-7001K system&#46; The treatment protocols were those recommended by the Spanish Photobiology Group &#40;Grupo Espa&#241;ol de Fotobiolog&#237;a&#41;&#46;<a class="elsevierStyleCrossRef" href="#bib0135"><span class="elsevierStyleSup">10</span></a></p><p id="par0080" class="elsevierStylePara elsevierViewall">Clinical and treatment-related data were retrieved from the records of the Photobiology and Phototherapy Unit of HGUV&#46; A retrospective follow-up was performed to investigate the appearance of skin cancer over time&#46; Patients were followed up by accessing data from the Unified Electronic Clinical History of the Autonomous Community of Valencia &#40;ABUCASIS&#41; and the database of the dermatopathology laboratory of HGUV&#46; The only cases considered positive were those in which the suspicious lesion was confirmed by histopathology&#46; Following the recommendations of epidemiological studies on skin cancer&#44; only the first tumor for each histologic type and patient was considered a case of NMSC&#46;<a class="elsevierStyleCrossRef" href="#bib0120"><span class="elsevierStyleSup">7</span></a> For each case&#44; the date the tumor appeared was recorded&#44; as were the location and the definitive histological diagnosis&#46;</p><p id="par0085" class="elsevierStylePara elsevierViewall">The date of the last face-to-face visit at the Dermatology Department of our hospital was recorded for all patients in order to establish the individual follow-up period&#46; The incidence density of NMSC was calculated&#44; as was the age-adjusted incidence density following the direct standardization method for age and sex in the world population described by Segi et al&#46;<a class="elsevierStyleCrossRef" href="#bib0140"><span class="elsevierStyleSup">11</span></a></p></span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0075">Results</span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0080">Characteristics of the Study Population</span><p id="par0090" class="elsevierStylePara elsevierViewall">We analyzed data from 474 patients treated with NB UV-B phototherapy between 2002 and 2016 and who had been followed for at least 1 year&#46; There were 193 men &#40;40&#46;7&#37;&#41; and 281 women &#40;59&#46;3&#37;&#41;&#46; The patients&#8217; characteristics are shown in <a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a>&#46;</p><elsevierMultimedia ident="tbl0005"></elsevierMultimedia><p id="par0095" class="elsevierStylePara elsevierViewall">Mean &#40;SD&#41; follow-up time was 5&#46;8 &#40;3&#41; years &#40;range&#44; 1&#46;1-14&#46;5&#41;&#46; Cumulative follow-up time was 2750 patient-years&#46; Mean age at the end of follow-up was 47&#46;5 &#40;20&#46;6&#41; years &#40;range&#44; 6&#46;7-98&#41;&#46;</p></span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0085">Tumors Detected</span><p id="par0100" class="elsevierStylePara elsevierViewall">Ten tumors were diagnosed in 9 patients during follow-up&#44; that is&#44; a prevalence of 1&#46;9&#37; at the end of the study period&#46; The tumors were basal cell carcinoma &#40;BCC&#41; in 6 cases and SCC in 4 cases&#46; Taking into account a single case per histologic type&#44; the prevalence of BCC was 1&#46;3&#37; and that of SCC was 0&#46;6&#37;&#46;</p><p id="par0105" class="elsevierStylePara elsevierViewall">When all the lesions diagnosed were taken into account&#44; the prevalence of NMSC was 2&#46;1&#37;&#46; The prevalence of BCC was 1&#46;3&#37; and that of SCC was 0&#46;6&#37;&#46;</p><p id="par0110" class="elsevierStylePara elsevierViewall">Mean age at initiation of phototherapy was higher in patients with tumors &#40;<a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a>&#41;&#46; No statistically significant differences were found for sex&#44; skin phototype&#44; or cumulative dose of NB UV-B&#44; regardless of whether or not the patient had developed a tumor&#46;</p><p id="par0115" class="elsevierStylePara elsevierViewall">The location of the lesions is shown in <a class="elsevierStyleCrossRef" href="#fig0005">Figure 1</a>&#46; Lesions were on the head in 6 cases &#40;60&#37;&#44; 3 SCC and 3 BCC&#41;&#44; the upper limbs in 3 cases &#40;30&#37;&#44; 2 BCC and 1 SCC&#41;&#44; and the trunk in 1 case &#40;10&#37;&#44; 1 BCC&#41; &#40;<a class="elsevierStyleCrossRef" href="#tbl0010">Table 2</a>&#41;&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><elsevierMultimedia ident="tbl0010"></elsevierMultimedia></span><span id="sec0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0090">Incidence of Skin Tumors</span><p id="par0120" class="elsevierStylePara elsevierViewall">Based on a single case per tumor and histologic type&#44; the incidence density of NMSC in patients treated with NB UV-B phototherapy was 327&#46;3&#47;100&#160;000 patient-years &#40;95&#37;&#160;CI&#44; 113&#46;5-541&#46;1&#41;&#46; After direct standardization adjusted for the age of the world population&#44; the adjusted incidence density of NMSC was 108&#46;3 cases per 100&#160;000 patient-years &#40;95&#37;&#160;CI&#44; 37&#46;5-179&#46;1&#41;&#46;</p></span></span><span id="sec0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0095">Discussion</span><p id="par0125" class="elsevierStylePara elsevierViewall">Our results confirm the initial hypothesis that the carcinogenic risk of NB UV-B phototherapy is low or nonexistent&#46;</p><p id="par0130" class="elsevierStylePara elsevierViewall">Our study is the largest to date on photocarcinogenesis in the Mediterranean area&#46; The mean follow-up time of 5&#46;8 years is similar to that of all previous studies on NB UV-B phototherapy &#40;<a class="elsevierStyleCrossRef" href="#tbl0015">Table 3</a>&#41;&#46; The sample is the largest to date in the Mediterranean area&#44;<a class="elsevierStyleCrossRefs" href="#bib0125"><span class="elsevierStyleSup">8&#44;9</span></a> although much lower than that of the 2 main studies on photocarcinogenesis associated with NB UV-B phototherapy&#46;<a class="elsevierStyleCrossRefs" href="#bib0145"><span class="elsevierStyleSup">12&#44;13</span></a></p><elsevierMultimedia ident="tbl0015"></elsevierMultimedia><p id="par0135" class="elsevierStylePara elsevierViewall">Mean age at the end of follow-up &#40;47&#46;5 &#91;20&#46;6&#93; years&#41; was similar to that found elsewhere&#46; Weischer et al&#46;<a class="elsevierStyleCrossRef" href="#bib0155"><span class="elsevierStyleSup">14</span></a> reported age at the end of follow-up to be 51&#46;2 years&#59; Hearn et al&#46;<a class="elsevierStyleCrossRef" href="#bib0145"><span class="elsevierStyleSup">12</span></a> reported it to be 39&#46;5 years&#46;</p><p id="par0140" class="elsevierStylePara elsevierViewall">Minimum follow-up time is very short in some studies&#44;<a class="elsevierStyleCrossRefs" href="#bib0145"><span class="elsevierStyleSup">12&#44;13</span></a> and no other studies report the cumulative time period in patient-years except Hearn et al&#46;<a class="elsevierStyleCrossRef" href="#bib0145"><span class="elsevierStyleSup">12</span></a> &#40;24&#160;753 patient-years&#41;&#46; The number of patient-years is a more reliable indicator of the total observation period than total follow-up time&#46; As this is an arithmetic measure&#44; the mean follow-up time loses validity when used in bimodal distributions&#46;</p><p id="par0145" class="elsevierStylePara elsevierViewall">We detected skin tumors in 1&#46;9&#37; of patients at the end of the study period&#46; This figure is lower that that reported by Maiorino et al&#46;<a class="elsevierStyleCrossRef" href="#bib0125"><span class="elsevierStyleSup">8</span></a> &#40;12&#37;&#41; and by Cuesta-Montero<a class="elsevierStyleCrossRef" href="#bib0130"><span class="elsevierStyleSup">9</span></a> &#40;5&#46;2&#37;&#41; but similar to that of other larger-scale studies such as that of Hearn et al&#46;<a class="elsevierStyleCrossRef" href="#bib0145"><span class="elsevierStyleSup">12</span></a> &#40;1&#37;&#41; and Man et al&#46;<a class="elsevierStyleCrossRef" href="#bib0150"><span class="elsevierStyleSup">13</span></a> &#40;0&#46;7&#37;&#41;&#46; The high prevalence reported in some studies<a class="elsevierStyleCrossRefs" href="#bib0125"><span class="elsevierStyleSup">8&#44;9</span></a> may be overestimated because of the low sample size&#46;</p><p id="par0150" class="elsevierStylePara elsevierViewall">The most frequent histological form detected was BCC &#40;60&#37;&#41;&#46; This finding is consistent with those of other studies<a class="elsevierStyleCrossRefs" href="#bib0130"><span class="elsevierStyleSup">9&#44;12&#8211;14</span></a> and similar to the percentage of this histologic type with respect to the total for NMSC in the general population &#40;74&#46;7&#37;&#41;&#46;<a class="elsevierStyleCrossRef" href="#bib0160"><span class="elsevierStyleSup">15</span></a></p><p id="par0155" class="elsevierStylePara elsevierViewall">The greater frequency of BCC contrasts with the findings reported for patients treated with PUVA in other studies&#44; which showed SCC to be the most common tumor&#46;<a class="elsevierStyleCrossRef" href="#bib0095"><span class="elsevierStyleSup">2</span></a> The high percentage of SCC is one of the factors thought to be associated with the carcinogenic effect of phototherapy&#59; consequently&#44; the lower frequency of this tumor in the present study supports the lesser carcinogenic effect of this modality&#46;</p><p id="par0160" class="elsevierStylePara elsevierViewall">The total cumulative dose was similar in patients who developed skin tumors and in those who did not&#44; with no significant differences&#46; This finding could indicate that NB UV-B radiation has no clear dose-dependent carcinogenic effect or that it did not reach the carcinogenic threshold for this treatment modality&#46; The differences detected in our study are clinically irrelevant &#40;38&#46;2<span class="elsevierStyleHsp" style=""></span>J&#47;cm<span class="elsevierStyleSup">2</span> vs 36&#46;6<span class="elsevierStyleHsp" style=""></span>J&#47;cm<span class="elsevierStyleSup">2</span>&#41;&#59; therefore&#44; it is unlikely that studies with a larger sample size would yield clinically significant results&#46;</p><p id="par0165" class="elsevierStylePara elsevierViewall">Age at initiation of phototherapy was higher in patients with tumors&#44; possibly because&#44; as the follow-up period was relatively short&#44; patients who started phototherapy at an older age were followed for longer&#44; thus increasing the cumulative risk of NMSC&#46; This potential bias was corrected using the standardized incidence rate&#46;</p><p id="par0170" class="elsevierStylePara elsevierViewall">The most frequent location of the skin lesions was the head and upper limbs&#44; consistent with findings for the general population&#46;<a class="elsevierStyleCrossRef" href="#bib0165"><span class="elsevierStyleSup">16</span></a> No patients developed skin tumors on the legs&#44; in contrast with patients treated with PUVA&#44; in whom the lower limbs are one of the most frequently affected sites&#46;<a class="elsevierStyleCrossRef" href="#bib0105"><span class="elsevierStyleSup">4</span></a> The absence of lesions at this site is yet another indicator suggesting that the carcinogenic effect of NB UV-B radiation is lower than that of PUVA phototherapy&#46;</p><p id="par0175" class="elsevierStylePara elsevierViewall">The incidence density of skin tumors was 327&#46;3&#47;100&#160;000 patient-years&#44; which is much higher than in the general population &#40;115&#46;3&#47;100&#160;000 patient-years&#41;&#46;<a class="elsevierStyleCrossRef" href="#bib0160"><span class="elsevierStyleSup">15</span></a> However&#44; this result is difficult to compare&#44; because it depends to a large extent on the age of the study population&#44; which in the present case comprises adults followed over a more or less prolonged time period&#46;</p><p id="par0180" class="elsevierStylePara elsevierViewall">In contrast with the prevalence of NMSC&#44; no study to date has reported the incidence density of NMSC or of its clinical forms in patients treated with NB UV-B phototherapy&#46;<a class="elsevierStyleCrossRefs" href="#bib0125"><span class="elsevierStyleSup">8&#44;9&#44;12&#8211;14&#44;17</span></a></p><p id="par0185" class="elsevierStylePara elsevierViewall">Standardization for age and sex revealed an incidence density of NMSC lower than the gross density &#40;108&#46;3 vs 327&#46;3&#41;&#44; thus confirming that the sample studied was from an aging population &#40;as a result of the length of the follow-up period&#41;&#46; Therefore&#44; the carcinogenic effect of NB UV-B phototherapy would be overestimated without standardization for age&#46;</p><p id="par0190" class="elsevierStylePara elsevierViewall">Comparison of the incidence density of skin tumors with that of the population of Girona described by Vilar-Coromina<a class="elsevierStyleCrossRef" href="#bib0160"><span class="elsevierStyleSup">15</span></a> &#40;<a class="elsevierStyleCrossRef" href="#tbl0015">Table 3</a>&#41; revealed a standardized risk ratio of 1&#46;9&#44; which was not statistically significant&#46;</p><p id="par0195" class="elsevierStylePara elsevierViewall">The standardized risk ratio compared with the healthy population was obtained in the studies by Hearn et al&#46;<a class="elsevierStyleCrossRef" href="#bib0145"><span class="elsevierStyleSup">12</span></a> and Man et al&#46;<a class="elsevierStyleCrossRef" href="#bib0150"><span class="elsevierStyleSup">13</span></a> &#40;<a class="elsevierStyleCrossRef" href="#tbl0020">Table 4</a>&#41;&#46; In neither case was a potential carcinogenic effect of NB UV-B phototherapy demonstrated&#46; However&#44; it is noteworthy that all of the studies performed show a standardized risk ratio that leans positively toward NB UV-B phototherapy&#44; indicating potentially significant differences that could not be appreciated because of the low sample size&#46; Studies with longer follow-up periods would be advisable if we wish to increase the number of cases detected and the statistical power of the comparative tests&#46;</p><elsevierMultimedia ident="tbl0020"></elsevierMultimedia><p id="par0200" class="elsevierStylePara elsevierViewall">The median age at diagnosis of the skin tumors in patients treated with NB UV-B phototherapy was 71&#46;5 years&#46; This finding contrasts with the mean age of the population at the end of the study &#40;47&#46;5 years&#41;&#44; thus highlighting the importance of performing studies with long follow-up periods and especially studies that assess patients to an older age&#46; The carcinogenic risk of NB UV-B phototherapy seems to be a late phenomenon that does not appear immediately after treatment but rather is added to the patient&#39;s baseline risk&#44; with onset of the skin tumors at the usual age of presentation &#40;sixth and seventh decades of life&#41;&#46;</p><p id="par0205" class="elsevierStylePara elsevierViewall">The adjusted risk of NMSC attributable to exposure to NB UV-B compared with the general population<a class="elsevierStyleCrossRef" href="#bib0160"><span class="elsevierStyleSup">15</span></a> is 52&#46;6 cases per 100&#160;000 patient-years&#44; that is&#44; 1900 patients would need to be treated with the habitual doses of NB UV-B for 1 case of treatment-associated NMSC to occur&#46; This number needed to harm is very low given the habitual volume of patients treated at a phototherapy unit&#46; Therefore&#44; our results show that the risk of NMSC caused by NB UV-B phototherapy is very low and that this modality can be used safely in daily clinical practice&#46;</p><p id="par0210" class="elsevierStylePara elsevierViewall">In conclusion&#44; consistent with other studies&#44; we were unable to demonstrate a clinically relevant carcinogenic effect associated with NB UV-B phototherapy&#46; Nevertheless&#44; we cannot conclude that this treatment modality is risk-free&#46; Therefore&#44; studies with longer follow-up periods are essential if we are to confirm or rule out the carcinogenic risk of NB UV-B phototherapy&#46;</p></span><span id="sec0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0100">Conflicts of Interest</span><p id="par0215" class="elsevierStylePara elsevierViewall">The authors declare that they have no conflicts of interest&#46;</p></span></span>"
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      "en" => array:3 [
        "titulo" => "Abstract"
        "resumen" => "<span id="abst0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0010">Background</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">The risk of skin cancer in patients treated with narrowband &#40;NB&#41; UV-B phototherapy is not well understood&#46; Although experimental studies have shown that there is a risk&#44; clinical studies have not detected an increased incidence of cancer following treatment&#46; The aim of this study was to determine the incidence of nonmelanoma skin cancer &#40;NMSC&#41; in patients treated with NB UV-B phototherapy at a tertiary care hospital in the Mediterranean area&#46;</p></span> <span id="abst0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0015">Material and methods</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">We conducted a retrospective chart review of 474 patients who received whole-body NB UV-B phototherapy at our hospital between 2002 and 2016 and identified those diagnosed with NMSC during follow-up&#46; We calculated the corresponding crude and standardized incidence rates and compared these with rates in the general population in a similar geographic area&#46;</p></span> <span id="abst0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0020">Results</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Of the 474 patients&#44; 193 &#40;40&#46;7&#37;&#41; were men and 281 &#40;59&#46;3&#37;&#41; were women&#46; The mean &#40;SD&#41; follow-up period was 5&#46;8 &#40;3&#41; years&#46; The prevalence of NMSC at the end of the study period was 1&#46;9&#37; and the standardized incidence was 108&#46;3 cases per 100&#160;000 patient-years&#46; The SIR of 1&#46;9 in the study group was not significantly different from that of the general population&#46; The number of patients who needed to be treated with NB UV-B phototherapy for 1 case of NMSC to occur was 1900&#46;</p></span> <span id="abst0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0025">Conclusion</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">NB UV-B phototherapy does not appear to be associated with an increased risk of NMSC</p></span>"
        "secciones" => array:4 [
          0 => array:2 [
            "identificador" => "abst0005"
            "titulo" => "Background"
          ]
          1 => array:2 [
            "identificador" => "abst0010"
            "titulo" => "Material and methods"
          ]
          2 => array:2 [
            "identificador" => "abst0015"
            "titulo" => "Results"
          ]
          3 => array:2 [
            "identificador" => "abst0020"
            "titulo" => "Conclusion"
          ]
        ]
      ]
      "es" => array:3 [
        "titulo" => "Resumen"
        "resumen" => "<span id="abst0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0035">Introducci&#243;n</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">Actualmente el riesgo de c&#225;ncer cut&#225;neo asociado a la fototerapia UVB de banda estrecha no se conoce con precisi&#243;n&#46; Aunque existe un riesgo demostrado en estudios experimentales los estudios en la pr&#225;ctica cl&#237;nica no han encontrado un aumento en la frecuencia de neoplasias en los pacientes tratados con esta modalidad de fototerapia&#46; El objetivo de nuestro trabajo es determinar la incidencia de fotocarcinog&#233;nesis de la fototerapia UVB-BE en un hospital terciario del &#225;rea mediterr&#225;nea&#46;</p></span> <span id="abst0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0040">Material y m&#233;todo</span><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">Se ha realizado un estudio observacional retrospectivo selecionando 474 pacientes que hab&#237;an recibido tratamiento con UVB-BE de cuerpo completo entre 2002 y 2016 realizando un seguimiento en la historia cl&#237;nica revisando los pacientes que hab&#237;an sido diagnosticados de CCNM&#46; Se calcul&#243; la densidad de incidencia bruta y ajustada y se compar&#243; con la frecuencia en la poblaci&#243;n normal de un area geogr&#225;fica similar&#46;</p></span> <span id="abst0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0045">Resultados</span><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">De los 474 pacientes estudiados&#44; 193 eran hombres &#40;40&#44;7&#37;&#41; y 281 mujeres &#40;59&#44;3&#37;&#41;&#46; El tiempo medio de seguimiento fue de 5&#44;8&#43;-3 a&#241;os&#46; La prevalencia de neoplasias al final del periodo de estudio fue del 1&#44;9&#37; La densidad de incidencia ajustada fue de 108&#44;3 casos &#47; 100&#46;000 pacientes tratados &#8211; a&#241;o&#46; La relaci&#243;n estandarizada de riesgo en comparaci&#243;n con la poblaci&#243;n general fue de 1&#44;9 sin llegar a ser estad&#237;sticamente significativa&#46; El n&#250;mero necesario a tratar para producir un caso de c&#225;ncer cut&#225;neo fue de 1&#46;900 pacientes&#46;</p></span> <span id="abst0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0050">Conclusi&#243;n</span><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">La fototerapia UVB-BE no parece asociarse con un riesgo aumentado de c&#225;ncer cut&#225;neo no melanoma en los pacientes tratados con esta modalidad de tratamiento&#46;</p></span>"
        "secciones" => array:4 [
          0 => array:2 [
            "identificador" => "abst0025"
            "titulo" => "Introducci&#243;n"
          ]
          1 => array:2 [
            "identificador" => "abst0030"
            "titulo" => "Material y m&#233;todo"
          ]
          2 => array:2 [
            "identificador" => "abst0035"
            "titulo" => "Resultados"
          ]
          3 => array:2 [
            "identificador" => "abst0040"
            "titulo" => "Conclusi&#243;n"
          ]
        ]
      ]
    ]
    "NotaPie" => array:1 [
      0 => array:2 [
        "etiqueta" => "&#9734;"
        "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Please cite this article as&#58; Ortiz-Salvador JM&#44; Ferrer DS&#44; Saneleuterio-Temporal M&#44; Victoria Mart&#237;nez AM&#44; Ferriols AP&#44; Vilata Corell JJ&#44; et al&#46; Riesgo de fotocarcinog&#233;nesis asociado a la fototerapia UVB-BE&#46; Estudio epidemiol&#243;gico de un hospital terciario&#46; Actas Dermosifiliogr&#46; 2018&#59;109&#58;340&#8211;345&#46;</p>"
      ]
    ]
    "multimedia" => array:5 [
      0 => array:7 [
        "identificador" => "fig0005"
        "etiqueta" => "Figure 1"
        "tipo" => "MULTIMEDIAFIGURA"
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        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr1.jpeg"
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        "descripcion" => array:1 [
          "en" => "<p id="spar0045" class="elsevierStyleSimplePara elsevierViewall">Location of skin cancer in study patients treated with NB UV-B phototherapy&#46; Basal cell carcinoma is shown in blue and squamous cell carcinoma in red&#46;</p>"
        ]
      ]
      1 => array:8 [
        "identificador" => "tbl0005"
        "etiqueta" => "Table 1"
        "tipo" => "MULTIMEDIATABLA"
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        "tabla" => array:2 [
          "leyenda" => "<p id="spar0055" class="elsevierStyleSimplePara elsevierViewall">Abbreviations&#58; NB&#44; narrowband&#59; NMSC&#44; nonmelanoma skin cancer&#46;</p>"
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                0 => """
                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="table-head  " align="" valign="top" scope="col" style="border-bottom: 2px solid black">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Patients Treated with NB UV-B Phototherapy Who Did Not Develop Tumors&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Patients Treated with NB UV-B Phototherapy Who Developed Tumors&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black"><span class="elsevierStyleItalic">P</span> Value&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Age at initiation of phototherapy&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">41&#46;5&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">65&#46;9&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#60;&#46;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Male sex&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">40&#46;40&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">55&#46;60&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#46;496&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Skin phototype&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">I&#44; 3&#46;4&#37;&#59; II&#44; 28&#46;4&#37;&#59; III&#44; 54&#46;4&#37;&#59; IV&#44; 12&#46;7&#37;&#59; V&#44; 0&#46;9&#37;&#59; VI&#44; 0&#46;2&#37;&#46;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">II&#44; 66&#46;7&#37;&#59; III&#44; 22&#46;2&#37;&#59; IV&#44; 11&#46;1&#37;&#46;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#46;255&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Mean cumulative dose of NB UV-B&#44; J&#47;cm<span class="elsevierStyleSup">2</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">36&#46;6&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">38&#46;2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#46;900&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
              ]
              "imagenFichero" => array:1 [
                0 => "xTab1737258.png"
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        "descripcion" => array:1 [
          "en" => "<p id="spar0050" class="elsevierStyleSimplePara elsevierViewall">Epidemiological Characteristics of Patients Treated with NB UV-B Who Developed and Did Not Develop NMSC&#46;</p>"
        ]
      ]
      2 => array:8 [
        "identificador" => "tbl0010"
        "etiqueta" => "Table 2"
        "tipo" => "MULTIMEDIATABLA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "detalles" => array:1 [
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            "identificador" => "at2"
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            "rol" => "short"
          ]
        ]
        "tabla" => array:2 [
          "leyenda" => "<p id="spar0065" class="elsevierStyleSimplePara elsevierViewall">Abbreviations&#58; BCC&#44; basal cell cancer&#59; MF&#44; mycosis fungoides&#59; NB&#44; narrowband&#59; NMSC&#44; nonmelanoma skin cancer&#59; SCC&#44; squamous cell cancer&#46;</p>"
          "tablatextoimagen" => array:1 [
            0 => array:2 [
              "tabla" => array:1 [
                0 => """
                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Patient&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Sex&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Phototype&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Disease&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Age at Initiation of NB UV-B&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Type &#40;Quantity&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Location&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Age at Onset&#44; y&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Time Until First Tumor&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Cumulative Dose&#44; J&#47;cm<span class="elsevierStyleSup">2</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">M&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">II&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">MF&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">75&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">SCC &#40;2&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Chin&#44; lower lip&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">80&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">3&#46;8&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">12&#46;4&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">M&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">II&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Cholestatic pruritus&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">70&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">SCC &#40;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Scalp&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">71&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#46;7&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">47&#46;7&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">M&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">III&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Atopic dermatitis&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">70&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">SCC &#40;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Dorsum of hand&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">72&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">1&#46;6&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">33&#46;8&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">4&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">F&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">II&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">MF&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">49&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">BCC &#40;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Shoulder&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">51&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">1&#46;7&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">22&#46;1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">5&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">F&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">IV&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Psoriasis&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">46&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">BCC &#40;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Inframammary area&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">49&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">3&#46;0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">136&#46;7&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">6&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">M&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">II&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Psoriasis&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">72&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">BCC &#40;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Left arm&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">75&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">3&#46;0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">3&#46;5&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">7&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">F&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">III&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">MF&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">61&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">BCC &#40;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Forehead&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">68&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">5&#46;7&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">37&#46;2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">8&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">F&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">II&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Psoriasis&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">78&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">BCC &#40;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Right temple&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">79&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#46;5&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">45&#46;8&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">9&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">F&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">II&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Psoriasis&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">67&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">BCC &#40;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Right infraorbital area&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">68&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#46;3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">5&#46;1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
              ]
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                0 => "xTab1737259.png"
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        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0060" class="elsevierStyleSimplePara elsevierViewall">Characteristics of Patients Who Developed Tumors&#46;</p>"
        ]
      ]
      3 => array:8 [
        "identificador" => "tbl0015"
        "etiqueta" => "Table 3"
        "tipo" => "MULTIMEDIATABLA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "detalles" => array:1 [
          0 => array:3 [
            "identificador" => "at3"
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        "tabla" => array:2 [
          "leyenda" => "<p id="spar0075" class="elsevierStyleSimplePara elsevierViewall">Abbreviations&#58; BCC&#44; basal cell cancer&#59; NB&#44; narrowband&#59; NMSC&#44; nonmelanoma skin cancer&#59; SCC&#44; squamous cell cancer&#46;</p>"
          "tablatextoimagen" => array:1 [
            0 => array:2 [
              "tabla" => array:1 [
                0 => """
                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="table-head  " align="" valign="top" scope="col" style="border-bottom: 2px solid black">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Total&#44; Cases&#47;100&#160;000 Patient-Years &#40;95&#37;&#160;CI&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Standardized&#44; Cases&#47;100&#160;000 Patient-Years &#40;95&#37;&#160;CI&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Present study&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">NMSC&#44; 327&#46;3 &#40;113&#46;5-541&#46;1&#41;&#59; BCC&#44; 218&#46;2 &#40;43&#46;6-392&#46;8&#41;&#59; SCC&#44; 109&#46;1 &#40;14&#46;3-232&#46;5&#41;&#46;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">NMSC&#44; 108&#46;3 &#40;37&#46;5-179&#46;1&#41;&#59; BCC&#44; 83&#46;7 &#40;16&#46;5-150&#46;9&#41;&#59; SCC&#44; 24&#46;6 &#40;&#8211;3&#46;8 to 53&#41;&#46;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">General population<a class="elsevierStyleCrossRef" href="#bib0160"><span class="elsevierStyleSup">15</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">NMSC&#44; 115&#46;3&#59; BCC&#44; 86&#46;15&#59; SCC&#44; 29&#46;15&#46;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">NMSC&#44; 55&#46;7 &#40;54&#46;5-57&#46;8&#41;&#59; BCC&#44; 44&#46;6 &#40;43&#46;4-45&#46;7&#41;&#59; SCC 11&#46;2 &#40;10&#46;7-11&#46;7&#41;&#46;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Risk ratio&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">NMSC&#44; 2&#46;8 &#40;1&#46;3-5&#46;4&#41;&#59; BCC&#44; 2&#46;5 &#40;0&#46;9-5&#46;5&#41;&#59; SCC&#44; 3&#46;7 &#40;0&#46;8-10&#46;9&#41;&#46;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">NMSC&#44; 1&#46;9 &#40;0&#46;64-5&#46;94&#41;&#59; BCC&#44; 1&#46;9 &#40;0&#46;4-6&#46;4&#41;&#59; SCC&#44; 2&#46;2 &#40;0&#46;5-20&#46;7&#41;&#46;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
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                0 => "xTab1737260.png"
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        "descripcion" => array:1 [
          "en" => "<p id="spar0070" class="elsevierStyleSimplePara elsevierViewall">Total and Standardized Incidence Density of Skin Tumors in Patients Treated With NB UV-B Phototherapy in Our Study and in the Healthy Population in Girona&#46; Risk of NMSC in Patients Treated With NB UV-B Phototherapy in Our Study&#46;</p>"
        ]
      ]
      4 => array:8 [
        "identificador" => "tbl0020"
        "etiqueta" => "Table 4"
        "tipo" => "MULTIMEDIATABLA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "detalles" => array:1 [
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          "leyenda" => "<p id="spar0085" class="elsevierStyleSimplePara elsevierViewall">Abbreviations&#58; BCC&#44; basal cell cancer&#59; NB&#44; narrowband&#59; NMSC&#44; nonmelanoma skin cancer&#59; NS&#44; not specified&#59; SCC&#44; squamous cell cancer&#46;</p>"
          "tablatextoimagen" => array:1 [
            0 => array:2 [
              "tabla" => array:1 [
                0 => """
                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="table-head  " align="" valign="top" scope="col" style="border-bottom: 2px solid black">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Study Area&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Mean Follow-up Time &#40;Minimum&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Sample Size&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Standardized Risk Ratio for General Population &#40;95&#37;&#160;CI&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Present study&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Spain &#40;Valencia&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">5&#46;8 y &#40;minimum 1 y&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">474 patients&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">NMSC&#44; 1&#46;9&#59; BCC&#44; 1&#46;9&#59;<br>SCC&#44; 2&#46;4&#46;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Cuesta-Montero<a class="elsevierStyleCrossRef" href="#bib0130"><span class="elsevierStyleSup">9</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Spain &#40;Alicante&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">4&#46;1 y &#40;minimum 3 y&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">154 patients&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Maiorino et al&#46;<a class="elsevierStyleCrossRef" href="#bib0125"><span class="elsevierStyleSup">8</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Italy &#40;Rome&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">4&#47;10 y &#40;minimum 1-4 y&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">50 patients&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Black and Gavin&#46;<a class="elsevierStyleCrossRef" href="#bib0170"><span class="elsevierStyleSup">17</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Northern Ireland&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">NS&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">484 patients&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Hearn et al&#46;<a class="elsevierStyleCrossRef" href="#bib0145"><span class="elsevierStyleSup">12</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Scotland&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">5&#46;5 y &#40;minimum 6 mo&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">3886 patients&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">SCC&#44; 2&#46;0 &#40;0&#46;2-17&#46;8&#41;&#59;<br>BCC&#44; 1&#46;2 &#40;0&#46;3-4&#46;2&#41;&#46;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Man et al&#46;&#44;<a class="elsevierStyleCrossRef" href="#bib0150"><span class="elsevierStyleSup">13</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Scotland&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">4 y &#40;minimum 15 d&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">1908 patients&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">SCC&#44; 1&#46;5 &#40;0&#46;2-5&#46;4&#41;&#59; BCC 2&#46;1 &#40;1&#46;0-3&#46;9&#41;&#46;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Weischer et al&#46;<a class="elsevierStyleCrossRef" href="#bib0155"><span class="elsevierStyleSup">14</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Germany &#40;Tubingen&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">5&#46;7 y &#40;minimum 2&#46;3 y&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">126 patients&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
              ]
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                0 => "xTab1737257.png"
              ]
            ]
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0080" class="elsevierStyleSimplePara elsevierViewall">Characteristics and Results of All Studies on the Photocarcinogenic Risk of NB UV-B Phototherapy Published in the Literature&#46;</p>"
        ]
      ]
    ]
    "bibliografia" => array:2 [
      "titulo" => "References"
      "seccion" => array:1 [
        0 => array:2 [
          "identificador" => "bibs0015"
          "bibliografiaReferencia" => array:17 [
            0 => array:3 [
              "identificador" => "bib0090"
              "etiqueta" => "1"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Survey of phototherapy practice by dermatologists in Australia"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "N&#46;T&#46; Huynh"
                            1 => "J&#46;R&#46; Sullivan"
                            2 => "C&#46;A&#46; Commens"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Australas J Dermatol&#46;"
                        "fecha" => "2002"
                        "volumen" => "43"
                        "paginaInicial" => "179"
                        "paginaFinal" => "185"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12121394"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            1 => array:3 [
              "identificador" => "bib0095"
              "etiqueta" => "2"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Carcinogenic risks of psoralen UV-A therapy and narrowband UV-B therapy in chronic plaque psoriasis&#58; a systematic literature review"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "E&#46; Archier"
                            1 => "S&#46; Devaux"
                            2 => "E&#46; Castela"
                            3 => "A&#46; Gallini"
                            4 => "F&#46; Aubin"
                            5 => "M&#46; Le Ma&#238;tre"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "J Eur Acad Dermatol Venereol JEADV&#46;"
                        "fecha" => "2012"
                        "volumen" => "3"
                        "numero" => "26 Suppl"
                        "paginaInicial" => "22"
                        "paginaFinal" => "31"
                      ]
                    ]
                  ]
                ]
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                      "titulo" => "British Association of Dermatologists and British Photodermatology Group guidelines for the safe and effective use of psoralen&#8211;ultraviolet A therapy 2015"
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                      "titulo" => "The risk of squamous cell and basal cell cancer associated with psoralen and ultraviolet A therapy&#58; a 30-year prospective study"
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                          "autores" => array:1 [
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                        "tituloSerie" => "J Am Acad Dermatol&#46;"
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                        "link" => array:1 [
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                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/22264671"
                            "web" => "Medline"
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                ]
              ]
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              "identificador" => "bib0110"
              "etiqueta" => "5"
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                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Effect of a new narrow-band UVB lamp on photocarcinogenesis in mice"
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                          "autores" => array:4 [
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                        "tituloSerie" => "Acta Derm Venereol&#46;"
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                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/1678230"
                            "web" => "Medline"
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              "identificador" => "bib0115"
              "etiqueta" => "6"
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                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Differences in narrow-band ultraviolet B and broad-spectrum ultraviolet photocarcinogenesis in lightly pigmented hairless mice"
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                          "autores" => array:3 [
                            0 => "H&#46;C&#46; Wulf"
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                            2 => "N&#46; Bech-Thomsen"
                          ]
                        ]
                      ]
                    ]
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                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Photodermatol Photoimmunol Photomed&#46;"
                        "fecha" => "1994"
                        "volumen" => "10"
                        "paginaInicial" => "192"
                        "paginaFinal" => "197"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7880757"
                            "web" => "Medline"
                          ]
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                    ]
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                ]
              ]
            ]
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              "etiqueta" => "7"
              "referencia" => array:1 [
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                    0 => array:2 [
                      "titulo" => "Incidencia y mortalidad del c&#225;ncer cut&#225;neo en Espa&#241;a&#58; revisi&#243;n sistem&#225;tica y metaan&#225;lisis"
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                            3 => "C&#46; Posada-Garc&#237;a"
                            4 => "L&#46; Rodr&#237;guez-Pazos"
                            5 => "I&#46; Pastushenko"
                          ]
                        ]
                      ]
                    ]
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                  "host" => array:1 [
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                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/26852370"
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                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Melanoma and non-melanoma skin cancer in psoriatic patients treated with high-dose phototherapy"
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                            4 => "K&#46; Peris"
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                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Documento de consenso sobre fototerapia&#58; terapias PUVA y UVB de banda estrecha"
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                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "J&#46;M&#46; Carrascosa"
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                            2 => "A&#46; P&#233;rez-Ferriols"
                            3 => "A&#46; Alomar"
                            4 => "P&#46; Manrique"
                            5 => "M&#46; Jones-Caballero"
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                    0 => array:1 [
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                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16476315"
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              "identificador" => "bib0140"
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                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Cancer mortality for selected sites in 24 countries"
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                        0 => array:2 [
                          "etal" => false
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                            0 => "M&#46; Segi"
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                    ]
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                  "host" => array:1 [
                    0 => array:1 [
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                        "editorialLocalizacion" => "Sendai"
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                    ]
                  ]
                ]
              ]
            ]
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              "identificador" => "bib0145"
              "etiqueta" => "12"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Incidence of skin cancers in 3867 patients treated with narrow-band ultraviolet B phototherapy"
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                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "R&#46;M&#46;R&#46; Hearn"
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                            2 => "K&#46;F&#46; Rahim"
                            3 => "J&#46; Ferguson"
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                    ]
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                    0 => array:2 [
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              "identificador" => "bib0150"
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              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The photocarcinogenic risk of narrowband UVB &#40;TL-01&#41; phototherapy&#58; early follow-up data"
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                            4 => "J&#46; Ferguson"
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                        ]
                      ]
                    ]
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                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1111/j.1365-2133.2005.06537.x"
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                            "web" => "Medline"
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                0 => array:2 [
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                    0 => array:2 [
                      "titulo" => "No evidence for increased skin cancer risk in psoriasis patients treated with broadband or narrowband UVB phototherapy&#58; a first retrospective study"
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                        0 => array:2 [
                          "etal" => false
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                        "paginaFinal" => "374"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15370703"
                            "web" => "Medline"
                          ]
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                      ]
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                  ]
                ]
              ]
            ]
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              "identificador" => "bib0160"
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                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "&#91;Non-melanoma skin cancer&#58; incidence time trends analysis in Girona Spain&#44; 1994-2007&#93;"
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                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
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                            1 => "J&#46; Mir&#243;-Queralt"
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                            3 => "L&#46; Vilardell-Gil"
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                    ]
                  ]
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                    0 => array:2 [
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                        "tituloSerie" => "Med Clin &#40;Barc&#41;&#46;"
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                0 => array:2 [
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                      "titulo" => "Actinic Keratosis&#46; Basal Cell Carcinoma and Squamous Cell Carcinoma"
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                          "etal" => false
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                0 => array:2 [
                  "contribucion" => array:1 [
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                      "titulo" => "Photocarcinogenic risk of narrowband ultraviolet B &#40;TL-01&#41; phototherapy&#58; early follow-up data"
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                          "etal" => false
                          "autores" => array:2 [
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                        "link" => array:1 [
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Original Article
Photocarcinogenic Risk Associated With Narrowband UV-B Phototherapy: An Epidemiologic Study in a Tertiary Care Hospital
Riesgo de fotocarcinogénesis asociado a la fototerapia UVB-BE. Estudio epidemiológico de un hospital terciario
J.M. Ortiz-Salvadora,
Autor para correspondencia
, D. Subiabre-Ferrera, M. Saneleuterio-Temporalb, A.M. Victoria Martíneza, A. Pérez-Ferriolsa, J.J. Vilata Corella, V. Alegre de Miquela
a Hospital General Universitario de Valencia. Servicio de Dermatología
b Hospital Universitario y Politécnico La Fe
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especially on the lower limbs&#46;<a class="elsevierStyleCrossRef" href="#bib0105"><span class="elsevierStyleSup">4</span></a></p><p id="par0020" class="elsevierStylePara elsevierViewall">Experimental studies have shown the carcinogenic effects of broadband UV-B phototherapy&#46; NB UV-B has proven to be more carcinogenic than broadband UV-B in animals&#46;<a class="elsevierStyleCrossRefs" href="#bib0110"><span class="elsevierStyleSup">5&#44;6</span></a> Nevertheless&#44; no clinical practice&#8211;based study has managed to demonstrate an increased risk of NMSC or melanoma associated with NB UV-B phototherapy&#46;<a class="elsevierStyleCrossRef" href="#bib0095"><span class="elsevierStyleSup">2</span></a></p><p id="par0025" class="elsevierStylePara elsevierViewall">The incidence of NMSC varies considerably according to several factors &#40;eg&#44; geographic region&#44; skin phototype&#44; and sun exposure habits&#41;&#46; Therefore&#44; caution should be exercised when extrapolating the findings of epidemiological studies on NMSC performed in specific geographical regions to other populations&#46; In the case of the Spanish population&#44; several studies have determined the incidence of NMSC in populations from different geographic areas&#46;<a class="elsevierStyleCrossRef" href="#bib0120"><span class="elsevierStyleSup">7</span></a></p><p id="par0030" class="elsevierStylePara elsevierViewall">As for data on NMSC in patients treated with NB UV-B&#44; current studies in the Mediterranean area are scarce and heterogeneous and based on small samples&#46;<a class="elsevierStyleCrossRefs" href="#bib0125"><span class="elsevierStyleSup">8&#44;9</span></a></p><p id="par0035" class="elsevierStylePara elsevierViewall">Under the working hypothesis that NB UV-B phototherapy has a low or nonexistent risk of carcinogenesis&#44; the main objective of the present study was to determine the incidence of skin cancer in patients treated with NB UV-B phototherapy and to compare it with the incidence among the general population in a similar geographic area&#46;</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0070">Material and Methods</span><p id="par0040" class="elsevierStylePara elsevierViewall">We performed a retrospective observational study of 474 patients who had received full-body NB UV-B phototherapy between 2002 and 2016 at the Photobiology and Phototherapy Unit of Hospital General Universitario de Valencia &#40;HGUV&#41;&#44; Valencia&#44; Spain&#46;</p><p id="par0045" class="elsevierStylePara elsevierViewall">The inclusion and exclusion criteria are set out below&#46;</p><p id="par0050" class="elsevierStylePara elsevierViewall">Inclusion criteria<ul class="elsevierStyleList" id="lis0005"><li class="elsevierStyleListItem" id="lsti0005"><span class="elsevierStyleLabel">&#8226;</span><p id="par0055" class="elsevierStylePara elsevierViewall">Skin disease treated with NB UV-B phototherapy at the Photobiology and Phototherapy Unit of HGUV between 2002 and 2016&#46;</p></li><li class="elsevierStyleListItem" id="lsti0010"><span class="elsevierStyleLabel">&#8226;</span><p id="par0060" class="elsevierStylePara elsevierViewall">Data from at least 1 year of follow-up&#46;</p></li></ul></p><p id="par0065" class="elsevierStylePara elsevierViewall">Exclusion criteria<ul class="elsevierStyleList" id="lis0010"><li class="elsevierStyleListItem" id="lsti0015"><span class="elsevierStyleLabel">&#8226;</span><p id="par0070" class="elsevierStylePara elsevierViewall">Treatment with a phototherapy modality other than NB UV-B before treatment with NB UV-B or before the appearance of the first tumor&#46;</p></li></ul></p><p id="par0075" class="elsevierStylePara elsevierViewall">Patients received NB UV-B phototherapy using the Waldmann UV-7002 or Waldmann UV-7001K system&#46; The treatment protocols were those recommended by the Spanish Photobiology Group &#40;Grupo Espa&#241;ol de Fotobiolog&#237;a&#41;&#46;<a class="elsevierStyleCrossRef" href="#bib0135"><span class="elsevierStyleSup">10</span></a></p><p id="par0080" class="elsevierStylePara elsevierViewall">Clinical and treatment-related data were retrieved from the records of the Photobiology and Phototherapy Unit of HGUV&#46; A retrospective follow-up was performed to investigate the appearance of skin cancer over time&#46; Patients were followed up by accessing data from the Unified Electronic Clinical History of the Autonomous Community of Valencia &#40;ABUCASIS&#41; and the database of the dermatopathology laboratory of HGUV&#46; The only cases considered positive were those in which the suspicious lesion was confirmed by histopathology&#46; Following the recommendations of epidemiological studies on skin cancer&#44; only the first tumor for each histologic type and patient was considered a case of NMSC&#46;<a class="elsevierStyleCrossRef" href="#bib0120"><span class="elsevierStyleSup">7</span></a> For each case&#44; the date the tumor appeared was recorded&#44; as were the location and the definitive histological diagnosis&#46;</p><p id="par0085" class="elsevierStylePara elsevierViewall">The date of the last face-to-face visit at the Dermatology Department of our hospital was recorded for all patients in order to establish the individual follow-up period&#46; The incidence density of NMSC was calculated&#44; as was the age-adjusted incidence density following the direct standardization method for age and sex in the world population described by Segi et al&#46;<a class="elsevierStyleCrossRef" href="#bib0140"><span class="elsevierStyleSup">11</span></a></p></span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0075">Results</span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0080">Characteristics of the Study Population</span><p id="par0090" class="elsevierStylePara elsevierViewall">We analyzed data from 474 patients treated with NB UV-B phototherapy between 2002 and 2016 and who had been followed for at least 1 year&#46; There were 193 men &#40;40&#46;7&#37;&#41; and 281 women &#40;59&#46;3&#37;&#41;&#46; The patients&#8217; characteristics are shown in <a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a>&#46;</p><elsevierMultimedia ident="tbl0005"></elsevierMultimedia><p id="par0095" class="elsevierStylePara elsevierViewall">Mean &#40;SD&#41; follow-up time was 5&#46;8 &#40;3&#41; years &#40;range&#44; 1&#46;1-14&#46;5&#41;&#46; Cumulative follow-up time was 2750 patient-years&#46; Mean age at the end of follow-up was 47&#46;5 &#40;20&#46;6&#41; years &#40;range&#44; 6&#46;7-98&#41;&#46;</p></span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0085">Tumors Detected</span><p id="par0100" class="elsevierStylePara elsevierViewall">Ten tumors were diagnosed in 9 patients during follow-up&#44; that is&#44; a prevalence of 1&#46;9&#37; at the end of the study period&#46; The tumors were basal cell carcinoma &#40;BCC&#41; in 6 cases and SCC in 4 cases&#46; Taking into account a single case per histologic type&#44; the prevalence of BCC was 1&#46;3&#37; and that of SCC was 0&#46;6&#37;&#46;</p><p id="par0105" class="elsevierStylePara elsevierViewall">When all the lesions diagnosed were taken into account&#44; the prevalence of NMSC was 2&#46;1&#37;&#46; The prevalence of BCC was 1&#46;3&#37; and that of SCC was 0&#46;6&#37;&#46;</p><p id="par0110" class="elsevierStylePara elsevierViewall">Mean age at initiation of phototherapy was higher in patients with tumors &#40;<a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a>&#41;&#46; No statistically significant differences were found for sex&#44; skin phototype&#44; or cumulative dose of NB UV-B&#44; regardless of whether or not the patient had developed a tumor&#46;</p><p id="par0115" class="elsevierStylePara elsevierViewall">The location of the lesions is shown in <a class="elsevierStyleCrossRef" href="#fig0005">Figure 1</a>&#46; Lesions were on the head in 6 cases &#40;60&#37;&#44; 3 SCC and 3 BCC&#41;&#44; the upper limbs in 3 cases &#40;30&#37;&#44; 2 BCC and 1 SCC&#41;&#44; and the trunk in 1 case &#40;10&#37;&#44; 1 BCC&#41; &#40;<a class="elsevierStyleCrossRef" href="#tbl0010">Table 2</a>&#41;&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><elsevierMultimedia ident="tbl0010"></elsevierMultimedia></span><span id="sec0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0090">Incidence of Skin Tumors</span><p id="par0120" class="elsevierStylePara elsevierViewall">Based on a single case per tumor and histologic type&#44; the incidence density of NMSC in patients treated with NB UV-B phototherapy was 327&#46;3&#47;100&#160;000 patient-years &#40;95&#37;&#160;CI&#44; 113&#46;5-541&#46;1&#41;&#46; After direct standardization adjusted for the age of the world population&#44; the adjusted incidence density of NMSC was 108&#46;3 cases per 100&#160;000 patient-years &#40;95&#37;&#160;CI&#44; 37&#46;5-179&#46;1&#41;&#46;</p></span></span><span id="sec0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0095">Discussion</span><p id="par0125" class="elsevierStylePara elsevierViewall">Our results confirm the initial hypothesis that the carcinogenic risk of NB UV-B phototherapy is low or nonexistent&#46;</p><p id="par0130" class="elsevierStylePara elsevierViewall">Our study is the largest to date on photocarcinogenesis in the Mediterranean area&#46; The mean follow-up time of 5&#46;8 years is similar to that of all previous studies on NB UV-B phototherapy &#40;<a class="elsevierStyleCrossRef" href="#tbl0015">Table 3</a>&#41;&#46; The sample is the largest to date in the Mediterranean area&#44;<a class="elsevierStyleCrossRefs" href="#bib0125"><span class="elsevierStyleSup">8&#44;9</span></a> although much lower than that of the 2 main studies on photocarcinogenesis associated with NB UV-B phototherapy&#46;<a class="elsevierStyleCrossRefs" href="#bib0145"><span class="elsevierStyleSup">12&#44;13</span></a></p><elsevierMultimedia ident="tbl0015"></elsevierMultimedia><p id="par0135" class="elsevierStylePara elsevierViewall">Mean age at the end of follow-up &#40;47&#46;5 &#91;20&#46;6&#93; years&#41; was similar to that found elsewhere&#46; Weischer et al&#46;<a class="elsevierStyleCrossRef" href="#bib0155"><span class="elsevierStyleSup">14</span></a> reported age at the end of follow-up to be 51&#46;2 years&#59; Hearn et al&#46;<a class="elsevierStyleCrossRef" href="#bib0145"><span class="elsevierStyleSup">12</span></a> reported it to be 39&#46;5 years&#46;</p><p id="par0140" class="elsevierStylePara elsevierViewall">Minimum follow-up time is very short in some studies&#44;<a class="elsevierStyleCrossRefs" href="#bib0145"><span class="elsevierStyleSup">12&#44;13</span></a> and no other studies report the cumulative time period in patient-years except Hearn et al&#46;<a class="elsevierStyleCrossRef" href="#bib0145"><span class="elsevierStyleSup">12</span></a> &#40;24&#160;753 patient-years&#41;&#46; The number of patient-years is a more reliable indicator of the total observation period than total follow-up time&#46; As this is an arithmetic measure&#44; the mean follow-up time loses validity when used in bimodal distributions&#46;</p><p id="par0145" class="elsevierStylePara elsevierViewall">We detected skin tumors in 1&#46;9&#37; of patients at the end of the study period&#46; This figure is lower that that reported by Maiorino et al&#46;<a class="elsevierStyleCrossRef" href="#bib0125"><span class="elsevierStyleSup">8</span></a> &#40;12&#37;&#41; and by Cuesta-Montero<a class="elsevierStyleCrossRef" href="#bib0130"><span class="elsevierStyleSup">9</span></a> &#40;5&#46;2&#37;&#41; but similar to that of other larger-scale studies such as that of Hearn et al&#46;<a class="elsevierStyleCrossRef" href="#bib0145"><span class="elsevierStyleSup">12</span></a> &#40;1&#37;&#41; and Man et al&#46;<a class="elsevierStyleCrossRef" href="#bib0150"><span class="elsevierStyleSup">13</span></a> &#40;0&#46;7&#37;&#41;&#46; The high prevalence reported in some studies<a class="elsevierStyleCrossRefs" href="#bib0125"><span class="elsevierStyleSup">8&#44;9</span></a> may be overestimated because of the low sample size&#46;</p><p id="par0150" class="elsevierStylePara elsevierViewall">The most frequent histological form detected was BCC &#40;60&#37;&#41;&#46; This finding is consistent with those of other studies<a class="elsevierStyleCrossRefs" href="#bib0130"><span class="elsevierStyleSup">9&#44;12&#8211;14</span></a> and similar to the percentage of this histologic type with respect to the total for NMSC in the general population &#40;74&#46;7&#37;&#41;&#46;<a class="elsevierStyleCrossRef" href="#bib0160"><span class="elsevierStyleSup">15</span></a></p><p id="par0155" class="elsevierStylePara elsevierViewall">The greater frequency of BCC contrasts with the findings reported for patients treated with PUVA in other studies&#44; which showed SCC to be the most common tumor&#46;<a class="elsevierStyleCrossRef" href="#bib0095"><span class="elsevierStyleSup">2</span></a> The high percentage of SCC is one of the factors thought to be associated with the carcinogenic effect of phototherapy&#59; consequently&#44; the lower frequency of this tumor in the present study supports the lesser carcinogenic effect of this modality&#46;</p><p id="par0160" class="elsevierStylePara elsevierViewall">The total cumulative dose was similar in patients who developed skin tumors and in those who did not&#44; with no significant differences&#46; This finding could indicate that NB UV-B radiation has no clear dose-dependent carcinogenic effect or that it did not reach the carcinogenic threshold for this treatment modality&#46; The differences detected in our study are clinically irrelevant &#40;38&#46;2<span class="elsevierStyleHsp" style=""></span>J&#47;cm<span class="elsevierStyleSup">2</span> vs 36&#46;6<span class="elsevierStyleHsp" style=""></span>J&#47;cm<span class="elsevierStyleSup">2</span>&#41;&#59; therefore&#44; it is unlikely that studies with a larger sample size would yield clinically significant results&#46;</p><p id="par0165" class="elsevierStylePara elsevierViewall">Age at initiation of phototherapy was higher in patients with tumors&#44; possibly because&#44; as the follow-up period was relatively short&#44; patients who started phototherapy at an older age were followed for longer&#44; thus increasing the cumulative risk of NMSC&#46; This potential bias was corrected using the standardized incidence rate&#46;</p><p id="par0170" class="elsevierStylePara elsevierViewall">The most frequent location of the skin lesions was the head and upper limbs&#44; consistent with findings for the general population&#46;<a class="elsevierStyleCrossRef" href="#bib0165"><span class="elsevierStyleSup">16</span></a> No patients developed skin tumors on the legs&#44; in contrast with patients treated with PUVA&#44; in whom the lower limbs are one of the most frequently affected sites&#46;<a class="elsevierStyleCrossRef" href="#bib0105"><span class="elsevierStyleSup">4</span></a> The absence of lesions at this site is yet another indicator suggesting that the carcinogenic effect of NB UV-B radiation is lower than that of PUVA phototherapy&#46;</p><p id="par0175" class="elsevierStylePara elsevierViewall">The incidence density of skin tumors was 327&#46;3&#47;100&#160;000 patient-years&#44; which is much higher than in the general population &#40;115&#46;3&#47;100&#160;000 patient-years&#41;&#46;<a class="elsevierStyleCrossRef" href="#bib0160"><span class="elsevierStyleSup">15</span></a> However&#44; this result is difficult to compare&#44; because it depends to a large extent on the age of the study population&#44; which in the present case comprises adults followed over a more or less prolonged time period&#46;</p><p id="par0180" class="elsevierStylePara elsevierViewall">In contrast with the prevalence of NMSC&#44; no study to date has reported the incidence density of NMSC or of its clinical forms in patients treated with NB UV-B phototherapy&#46;<a class="elsevierStyleCrossRefs" href="#bib0125"><span class="elsevierStyleSup">8&#44;9&#44;12&#8211;14&#44;17</span></a></p><p id="par0185" class="elsevierStylePara elsevierViewall">Standardization for age and sex revealed an incidence density of NMSC lower than the gross density &#40;108&#46;3 vs 327&#46;3&#41;&#44; thus confirming that the sample studied was from an aging population &#40;as a result of the length of the follow-up period&#41;&#46; Therefore&#44; the carcinogenic effect of NB UV-B phototherapy would be overestimated without standardization for age&#46;</p><p id="par0190" class="elsevierStylePara elsevierViewall">Comparison of the incidence density of skin tumors with that of the population of Girona described by Vilar-Coromina<a class="elsevierStyleCrossRef" href="#bib0160"><span class="elsevierStyleSup">15</span></a> &#40;<a class="elsevierStyleCrossRef" href="#tbl0015">Table 3</a>&#41; revealed a standardized risk ratio of 1&#46;9&#44; which was not statistically significant&#46;</p><p id="par0195" class="elsevierStylePara elsevierViewall">The standardized risk ratio compared with the healthy population was obtained in the studies by Hearn et al&#46;<a class="elsevierStyleCrossRef" href="#bib0145"><span class="elsevierStyleSup">12</span></a> and Man et al&#46;<a class="elsevierStyleCrossRef" href="#bib0150"><span class="elsevierStyleSup">13</span></a> &#40;<a class="elsevierStyleCrossRef" href="#tbl0020">Table 4</a>&#41;&#46; In neither case was a potential carcinogenic effect of NB UV-B phototherapy demonstrated&#46; However&#44; it is noteworthy that all of the studies performed show a standardized risk ratio that leans positively toward NB UV-B phototherapy&#44; indicating potentially significant differences that could not be appreciated because of the low sample size&#46; Studies with longer follow-up periods would be advisable if we wish to increase the number of cases detected and the statistical power of the comparative tests&#46;</p><elsevierMultimedia ident="tbl0020"></elsevierMultimedia><p id="par0200" class="elsevierStylePara elsevierViewall">The median age at diagnosis of the skin tumors in patients treated with NB UV-B phototherapy was 71&#46;5 years&#46; This finding contrasts with the mean age of the population at the end of the study &#40;47&#46;5 years&#41;&#44; thus highlighting the importance of performing studies with long follow-up periods and especially studies that assess patients to an older age&#46; The carcinogenic risk of NB UV-B phototherapy seems to be a late phenomenon that does not appear immediately after treatment but rather is added to the patient&#39;s baseline risk&#44; with onset of the skin tumors at the usual age of presentation &#40;sixth and seventh decades of life&#41;&#46;</p><p id="par0205" class="elsevierStylePara elsevierViewall">The adjusted risk of NMSC attributable to exposure to NB UV-B compared with the general population<a class="elsevierStyleCrossRef" href="#bib0160"><span class="elsevierStyleSup">15</span></a> is 52&#46;6 cases per 100&#160;000 patient-years&#44; that is&#44; 1900 patients would need to be treated with the habitual doses of NB UV-B for 1 case of treatment-associated NMSC to occur&#46; This number needed to harm is very low given the habitual volume of patients treated at a phototherapy unit&#46; Therefore&#44; our results show that the risk of NMSC caused by NB UV-B phototherapy is very low and that this modality can be used safely in daily clinical practice&#46;</p><p id="par0210" class="elsevierStylePara elsevierViewall">In conclusion&#44; consistent with other studies&#44; we were unable to demonstrate a clinically relevant carcinogenic effect associated with NB UV-B phototherapy&#46; Nevertheless&#44; we cannot conclude that this treatment modality is risk-free&#46; Therefore&#44; studies with longer follow-up periods are essential if we are to confirm or rule out the carcinogenic risk of NB UV-B phototherapy&#46;</p></span><span id="sec0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0100">Conflicts of Interest</span><p id="par0215" class="elsevierStylePara elsevierViewall">The authors declare that they have no conflicts of interest&#46;</p></span></span>"
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            0 => "Phototherapy"
            1 => "Narrowband ultraviolet B"
            2 => "Photocarcinogenesis"
            3 => "Nonmelanoma skin cancer"
            4 => "Squamous cell carcinoma&#58; Basal cell carcinoma"
            5 => "Ultraviolet"
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            0 => "Fototerapia"
            1 => "Ultravioleta B de banda estrecha"
            2 => "Fotocarcinog&#233;nesis"
            3 => "C&#225;ncer cut&#225;neo no melanoma"
            4 => "Carcinoma epidermoide cut&#225;neo"
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        "resumen" => "<span id="abst0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0010">Background</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">The risk of skin cancer in patients treated with narrowband &#40;NB&#41; UV-B phototherapy is not well understood&#46; Although experimental studies have shown that there is a risk&#44; clinical studies have not detected an increased incidence of cancer following treatment&#46; The aim of this study was to determine the incidence of nonmelanoma skin cancer &#40;NMSC&#41; in patients treated with NB UV-B phototherapy at a tertiary care hospital in the Mediterranean area&#46;</p></span> <span id="abst0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0015">Material and methods</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">We conducted a retrospective chart review of 474 patients who received whole-body NB UV-B phototherapy at our hospital between 2002 and 2016 and identified those diagnosed with NMSC during follow-up&#46; We calculated the corresponding crude and standardized incidence rates and compared these with rates in the general population in a similar geographic area&#46;</p></span> <span id="abst0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0020">Results</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Of the 474 patients&#44; 193 &#40;40&#46;7&#37;&#41; were men and 281 &#40;59&#46;3&#37;&#41; were women&#46; The mean &#40;SD&#41; follow-up period was 5&#46;8 &#40;3&#41; years&#46; The prevalence of NMSC at the end of the study period was 1&#46;9&#37; and the standardized incidence was 108&#46;3 cases per 100&#160;000 patient-years&#46; The SIR of 1&#46;9 in the study group was not significantly different from that of the general population&#46; The number of patients who needed to be treated with NB UV-B phototherapy for 1 case of NMSC to occur was 1900&#46;</p></span> <span id="abst0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0025">Conclusion</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">NB UV-B phototherapy does not appear to be associated with an increased risk of NMSC</p></span>"
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        "resumen" => "<span id="abst0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0035">Introducci&#243;n</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">Actualmente el riesgo de c&#225;ncer cut&#225;neo asociado a la fototerapia UVB de banda estrecha no se conoce con precisi&#243;n&#46; Aunque existe un riesgo demostrado en estudios experimentales los estudios en la pr&#225;ctica cl&#237;nica no han encontrado un aumento en la frecuencia de neoplasias en los pacientes tratados con esta modalidad de fototerapia&#46; El objetivo de nuestro trabajo es determinar la incidencia de fotocarcinog&#233;nesis de la fototerapia UVB-BE en un hospital terciario del &#225;rea mediterr&#225;nea&#46;</p></span> <span id="abst0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0040">Material y m&#233;todo</span><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">Se ha realizado un estudio observacional retrospectivo selecionando 474 pacientes que hab&#237;an recibido tratamiento con UVB-BE de cuerpo completo entre 2002 y 2016 realizando un seguimiento en la historia cl&#237;nica revisando los pacientes que hab&#237;an sido diagnosticados de CCNM&#46; Se calcul&#243; la densidad de incidencia bruta y ajustada y se compar&#243; con la frecuencia en la poblaci&#243;n normal de un area geogr&#225;fica similar&#46;</p></span> <span id="abst0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0045">Resultados</span><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">De los 474 pacientes estudiados&#44; 193 eran hombres &#40;40&#44;7&#37;&#41; y 281 mujeres &#40;59&#44;3&#37;&#41;&#46; El tiempo medio de seguimiento fue de 5&#44;8&#43;-3 a&#241;os&#46; La prevalencia de neoplasias al final del periodo de estudio fue del 1&#44;9&#37; La densidad de incidencia ajustada fue de 108&#44;3 casos &#47; 100&#46;000 pacientes tratados &#8211; a&#241;o&#46; La relaci&#243;n estandarizada de riesgo en comparaci&#243;n con la poblaci&#243;n general fue de 1&#44;9 sin llegar a ser estad&#237;sticamente significativa&#46; El n&#250;mero necesario a tratar para producir un caso de c&#225;ncer cut&#225;neo fue de 1&#46;900 pacientes&#46;</p></span> <span id="abst0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0050">Conclusi&#243;n</span><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">La fototerapia UVB-BE no parece asociarse con un riesgo aumentado de c&#225;ncer cut&#225;neo no melanoma en los pacientes tratados con esta modalidad de tratamiento&#46;</p></span>"
        "secciones" => array:4 [
          0 => array:2 [
            "identificador" => "abst0025"
            "titulo" => "Introducci&#243;n"
          ]
          1 => array:2 [
            "identificador" => "abst0030"
            "titulo" => "Material y m&#233;todo"
          ]
          2 => array:2 [
            "identificador" => "abst0035"
            "titulo" => "Resultados"
          ]
          3 => array:2 [
            "identificador" => "abst0040"
            "titulo" => "Conclusi&#243;n"
          ]
        ]
      ]
    ]
    "NotaPie" => array:1 [
      0 => array:2 [
        "etiqueta" => "&#9734;"
        "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Please cite this article as&#58; Ortiz-Salvador JM&#44; Ferrer DS&#44; Saneleuterio-Temporal M&#44; Victoria Mart&#237;nez AM&#44; Ferriols AP&#44; Vilata Corell JJ&#44; et al&#46; Riesgo de fotocarcinog&#233;nesis asociado a la fototerapia UVB-BE&#46; Estudio epidemiol&#243;gico de un hospital terciario&#46; Actas Dermosifiliogr&#46; 2018&#59;109&#58;340&#8211;345&#46;</p>"
      ]
    ]
    "multimedia" => array:5 [
      0 => array:7 [
        "identificador" => "fig0005"
        "etiqueta" => "Figure 1"
        "tipo" => "MULTIMEDIAFIGURA"
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        "figura" => array:1 [
          0 => array:4 [
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        "descripcion" => array:1 [
          "en" => "<p id="spar0045" class="elsevierStyleSimplePara elsevierViewall">Location of skin cancer in study patients treated with NB UV-B phototherapy&#46; Basal cell carcinoma is shown in blue and squamous cell carcinoma in red&#46;</p>"
        ]
      ]
      1 => array:8 [
        "identificador" => "tbl0005"
        "etiqueta" => "Table 1"
        "tipo" => "MULTIMEDIATABLA"
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          "leyenda" => "<p id="spar0055" class="elsevierStyleSimplePara elsevierViewall">Abbreviations&#58; NB&#44; narrowband&#59; NMSC&#44; nonmelanoma skin cancer&#46;</p>"
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                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="table-head  " align="" valign="top" scope="col" style="border-bottom: 2px solid black">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Patients Treated with NB UV-B Phototherapy Who Did Not Develop Tumors&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Patients Treated with NB UV-B Phototherapy Who Developed Tumors&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black"><span class="elsevierStyleItalic">P</span> Value&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Age at initiation of phototherapy&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">41&#46;5&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">65&#46;9&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#60;&#46;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Male sex&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">40&#46;40&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">55&#46;60&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#46;496&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Skin phototype&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">I&#44; 3&#46;4&#37;&#59; II&#44; 28&#46;4&#37;&#59; III&#44; 54&#46;4&#37;&#59; IV&#44; 12&#46;7&#37;&#59; V&#44; 0&#46;9&#37;&#59; VI&#44; 0&#46;2&#37;&#46;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">II&#44; 66&#46;7&#37;&#59; III&#44; 22&#46;2&#37;&#59; IV&#44; 11&#46;1&#37;&#46;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#46;255&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Mean cumulative dose of NB UV-B&#44; J&#47;cm<span class="elsevierStyleSup">2</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">36&#46;6&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">38&#46;2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#46;900&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
              ]
              "imagenFichero" => array:1 [
                0 => "xTab1737258.png"
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        "descripcion" => array:1 [
          "en" => "<p id="spar0050" class="elsevierStyleSimplePara elsevierViewall">Epidemiological Characteristics of Patients Treated with NB UV-B Who Developed and Did Not Develop NMSC&#46;</p>"
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      2 => array:8 [
        "identificador" => "tbl0010"
        "etiqueta" => "Table 2"
        "tipo" => "MULTIMEDIATABLA"
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        "detalles" => array:1 [
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          "leyenda" => "<p id="spar0065" class="elsevierStyleSimplePara elsevierViewall">Abbreviations&#58; BCC&#44; basal cell cancer&#59; MF&#44; mycosis fungoides&#59; NB&#44; narrowband&#59; NMSC&#44; nonmelanoma skin cancer&#59; SCC&#44; squamous cell cancer&#46;</p>"
          "tablatextoimagen" => array:1 [
            0 => array:2 [
              "tabla" => array:1 [
                0 => """
                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Patient&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Sex&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Phototype&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Disease&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Age at Initiation of NB UV-B&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Type &#40;Quantity&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Location&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Age at Onset&#44; y&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Time Until First Tumor&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Cumulative Dose&#44; J&#47;cm<span class="elsevierStyleSup">2</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">M&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">II&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">MF&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">75&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">SCC &#40;2&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Chin&#44; lower lip&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">80&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">3&#46;8&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">12&#46;4&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">M&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">II&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Cholestatic pruritus&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">70&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">SCC &#40;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Scalp&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">71&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#46;7&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">47&#46;7&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">M&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">III&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Atopic dermatitis&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">70&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">SCC &#40;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Dorsum of hand&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">72&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">1&#46;6&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">33&#46;8&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">4&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">F&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">II&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">MF&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">49&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">BCC &#40;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Shoulder&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">51&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">1&#46;7&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">22&#46;1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">5&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">F&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">IV&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Psoriasis&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">46&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">BCC &#40;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Inframammary area&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">49&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">3&#46;0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">136&#46;7&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">6&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">M&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">II&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Psoriasis&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">72&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">BCC &#40;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Left arm&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">75&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">3&#46;0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">3&#46;5&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">7&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">F&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">III&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">MF&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">61&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">BCC &#40;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Forehead&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">68&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">5&#46;7&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">37&#46;2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">8&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">F&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">II&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Psoriasis&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">78&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">BCC &#40;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Right temple&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">79&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#46;5&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">45&#46;8&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">9&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">F&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">II&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Psoriasis&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">67&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">BCC &#40;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Right infraorbital area&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">68&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#46;3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">5&#46;1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
              ]
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        "descripcion" => array:1 [
          "en" => "<p id="spar0060" class="elsevierStyleSimplePara elsevierViewall">Characteristics of Patients Who Developed Tumors&#46;</p>"
        ]
      ]
      3 => array:8 [
        "identificador" => "tbl0015"
        "etiqueta" => "Table 3"
        "tipo" => "MULTIMEDIATABLA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
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            "identificador" => "at3"
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        "tabla" => array:2 [
          "leyenda" => "<p id="spar0075" class="elsevierStyleSimplePara elsevierViewall">Abbreviations&#58; BCC&#44; basal cell cancer&#59; NB&#44; narrowband&#59; NMSC&#44; nonmelanoma skin cancer&#59; SCC&#44; squamous cell cancer&#46;</p>"
          "tablatextoimagen" => array:1 [
            0 => array:2 [
              "tabla" => array:1 [
                0 => """
                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="table-head  " align="" valign="top" scope="col" style="border-bottom: 2px solid black">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Total&#44; Cases&#47;100&#160;000 Patient-Years &#40;95&#37;&#160;CI&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Standardized&#44; Cases&#47;100&#160;000 Patient-Years &#40;95&#37;&#160;CI&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Present study&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">NMSC&#44; 327&#46;3 &#40;113&#46;5-541&#46;1&#41;&#59; BCC&#44; 218&#46;2 &#40;43&#46;6-392&#46;8&#41;&#59; SCC&#44; 109&#46;1 &#40;14&#46;3-232&#46;5&#41;&#46;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">NMSC&#44; 108&#46;3 &#40;37&#46;5-179&#46;1&#41;&#59; BCC&#44; 83&#46;7 &#40;16&#46;5-150&#46;9&#41;&#59; SCC&#44; 24&#46;6 &#40;&#8211;3&#46;8 to 53&#41;&#46;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">General population<a class="elsevierStyleCrossRef" href="#bib0160"><span class="elsevierStyleSup">15</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">NMSC&#44; 115&#46;3&#59; BCC&#44; 86&#46;15&#59; SCC&#44; 29&#46;15&#46;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">NMSC&#44; 55&#46;7 &#40;54&#46;5-57&#46;8&#41;&#59; BCC&#44; 44&#46;6 &#40;43&#46;4-45&#46;7&#41;&#59; SCC 11&#46;2 &#40;10&#46;7-11&#46;7&#41;&#46;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Risk ratio&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">NMSC&#44; 2&#46;8 &#40;1&#46;3-5&#46;4&#41;&#59; BCC&#44; 2&#46;5 &#40;0&#46;9-5&#46;5&#41;&#59; SCC&#44; 3&#46;7 &#40;0&#46;8-10&#46;9&#41;&#46;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">NMSC&#44; 1&#46;9 &#40;0&#46;64-5&#46;94&#41;&#59; BCC&#44; 1&#46;9 &#40;0&#46;4-6&#46;4&#41;&#59; SCC&#44; 2&#46;2 &#40;0&#46;5-20&#46;7&#41;&#46;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
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        "descripcion" => array:1 [
          "en" => "<p id="spar0070" class="elsevierStyleSimplePara elsevierViewall">Total and Standardized Incidence Density of Skin Tumors in Patients Treated With NB UV-B Phototherapy in Our Study and in the Healthy Population in Girona&#46; Risk of NMSC in Patients Treated With NB UV-B Phototherapy in Our Study&#46;</p>"
        ]
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        "identificador" => "tbl0020"
        "etiqueta" => "Table 4"
        "tipo" => "MULTIMEDIATABLA"
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          "leyenda" => "<p id="spar0085" class="elsevierStyleSimplePara elsevierViewall">Abbreviations&#58; BCC&#44; basal cell cancer&#59; NB&#44; narrowband&#59; NMSC&#44; nonmelanoma skin cancer&#59; NS&#44; not specified&#59; SCC&#44; squamous cell cancer&#46;</p>"
          "tablatextoimagen" => array:1 [
            0 => array:2 [
              "tabla" => array:1 [
                0 => """
                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="table-head  " align="" valign="top" scope="col" style="border-bottom: 2px solid black">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Study Area&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Mean Follow-up Time &#40;Minimum&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Sample Size&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Standardized Risk Ratio for General Population &#40;95&#37;&#160;CI&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Present study&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Spain &#40;Valencia&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">5&#46;8 y &#40;minimum 1 y&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">474 patients&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">NMSC&#44; 1&#46;9&#59; BCC&#44; 1&#46;9&#59;<br>SCC&#44; 2&#46;4&#46;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Cuesta-Montero<a class="elsevierStyleCrossRef" href="#bib0130"><span class="elsevierStyleSup">9</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Spain &#40;Alicante&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">4&#46;1 y &#40;minimum 3 y&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">154 patients&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Maiorino et al&#46;<a class="elsevierStyleCrossRef" href="#bib0125"><span class="elsevierStyleSup">8</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Italy &#40;Rome&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">4&#47;10 y &#40;minimum 1-4 y&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">50 patients&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Black and Gavin&#46;<a class="elsevierStyleCrossRef" href="#bib0170"><span class="elsevierStyleSup">17</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Northern Ireland&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">NS&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">484 patients&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Hearn et al&#46;<a class="elsevierStyleCrossRef" href="#bib0145"><span class="elsevierStyleSup">12</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Scotland&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">5&#46;5 y &#40;minimum 6 mo&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">3886 patients&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">SCC&#44; 2&#46;0 &#40;0&#46;2-17&#46;8&#41;&#59;<br>BCC&#44; 1&#46;2 &#40;0&#46;3-4&#46;2&#41;&#46;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Man et al&#46;&#44;<a class="elsevierStyleCrossRef" href="#bib0150"><span class="elsevierStyleSup">13</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Scotland&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">4 y &#40;minimum 15 d&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">1908 patients&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">SCC&#44; 1&#46;5 &#40;0&#46;2-5&#46;4&#41;&#59; BCC 2&#46;1 &#40;1&#46;0-3&#46;9&#41;&#46;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Weischer et al&#46;<a class="elsevierStyleCrossRef" href="#bib0155"><span class="elsevierStyleSup">14</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Germany &#40;Tubingen&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">5&#46;7 y &#40;minimum 2&#46;3 y&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">126 patients&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
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                0 => "xTab1737257.png"
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        "descripcion" => array:1 [
          "en" => "<p id="spar0080" class="elsevierStyleSimplePara elsevierViewall">Characteristics and Results of All Studies on the Photocarcinogenic Risk of NB UV-B Phototherapy Published in the Literature&#46;</p>"
        ]
      ]
    ]
    "bibliografia" => array:2 [
      "titulo" => "References"
      "seccion" => array:1 [
        0 => array:2 [
          "identificador" => "bibs0015"
          "bibliografiaReferencia" => array:17 [
            0 => array:3 [
              "identificador" => "bib0090"
              "etiqueta" => "1"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Survey of phototherapy practice by dermatologists in Australia"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "N&#46;T&#46; Huynh"
                            1 => "J&#46;R&#46; Sullivan"
                            2 => "C&#46;A&#46; Commens"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Australas J Dermatol&#46;"
                        "fecha" => "2002"
                        "volumen" => "43"
                        "paginaInicial" => "179"
                        "paginaFinal" => "185"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12121394"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            1 => array:3 [
              "identificador" => "bib0095"
              "etiqueta" => "2"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Carcinogenic risks of psoralen UV-A therapy and narrowband UV-B therapy in chronic plaque psoriasis&#58; a systematic literature review"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "E&#46; Archier"
                            1 => "S&#46; Devaux"
                            2 => "E&#46; Castela"
                            3 => "A&#46; Gallini"
                            4 => "F&#46; Aubin"
                            5 => "M&#46; Le Ma&#238;tre"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "J Eur Acad Dermatol Venereol JEADV&#46;"
                        "fecha" => "2012"
                        "volumen" => "3"
                        "numero" => "26 Suppl"
                        "paginaInicial" => "22"
                        "paginaFinal" => "31"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            2 => array:3 [
              "identificador" => "bib0100"
              "etiqueta" => "3"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "British Association of Dermatologists and British Photodermatology Group guidelines for the safe and effective use of psoralen&#8211;ultraviolet A therapy 2015"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "T&#46;C&#46; Ling"
                            1 => "T&#46;H&#46; Clayton"
                            2 => "J&#46; Crawley"
                            3 => "L&#46;S&#46; Exton"
                            4 => "V&#46; Goulden"
                            5 => "S&#46; Ibbotson"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1111/bjd.14317"
                      "Revista" => array:6 [
                        "tituloSerie" => "Br J Dermatol&#46;"
                        "fecha" => "2016"
                        "volumen" => "174"
                        "paginaInicial" => "24"
                        "paginaFinal" => "55"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/26790656"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            3 => array:3 [
              "identificador" => "bib0105"
              "etiqueta" => "4"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The risk of squamous cell and basal cell cancer associated with psoralen and ultraviolet A therapy&#58; a 30-year prospective study"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "R&#46;S&#46; Stern"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.jaad.2011.04.004"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Am Acad Dermatol&#46;"
                        "fecha" => "2012"
                        "volumen" => "66"
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                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/22264671"
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            4 => array:3 [
              "identificador" => "bib0110"
              "etiqueta" => "5"
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                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Effect of a new narrow-band UVB lamp on photocarcinogenesis in mice"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "H&#46; Flindt-Hansen"
                            1 => "N&#46; McFadden"
                            2 => "T&#46; Eeg-Larsen"
                            3 => "P&#46; Thune"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Acta Derm Venereol&#46;"
                        "fecha" => "1991"
                        "volumen" => "71"
                        "paginaInicial" => "245"
                        "paginaFinal" => "248"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/1678230"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            5 => array:3 [
              "identificador" => "bib0115"
              "etiqueta" => "6"
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                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Differences in narrow-band ultraviolet B and broad-spectrum ultraviolet photocarcinogenesis in lightly pigmented hairless mice"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "H&#46;C&#46; Wulf"
                            1 => "A&#46;B&#46; Hansen"
                            2 => "N&#46; Bech-Thomsen"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Photodermatol Photoimmunol Photomed&#46;"
                        "fecha" => "1994"
                        "volumen" => "10"
                        "paginaInicial" => "192"
                        "paginaFinal" => "197"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7880757"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
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              "identificador" => "bib0120"
              "etiqueta" => "7"
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                    0 => array:2 [
                      "titulo" => "Incidencia y mortalidad del c&#225;ncer cut&#225;neo en Espa&#241;a&#58; revisi&#243;n sistem&#225;tica y metaan&#225;lisis"
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                            2 => "M&#46;M&#46; Otero-Rivas"
                            3 => "C&#46; Posada-Garc&#237;a"
                            4 => "L&#46; Rodr&#237;guez-Pazos"
                            5 => "I&#46; Pastushenko"
                          ]
                        ]
                      ]
                    ]
                  ]
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                    0 => array:2 [
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                        "tituloSerie" => "Actas Dermo-sifiliogr&#225;ficas&#46;"
                        "fecha" => "2016"
                        "volumen" => "107"
                        "paginaInicial" => "318"
                        "paginaFinal" => "328"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/26852370"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
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              "identificador" => "bib0125"
              "etiqueta" => "8"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Melanoma and non-melanoma skin cancer in psoriatic patients treated with high-dose phototherapy"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "A&#46; Maiorino"
                            1 => "C&#46; De Simone"
                            2 => "F&#46; Perino"
                            3 => "G&#46; Caldarola"
                            4 => "K&#46; Peris"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "J Dermatol Treat&#46;"
                        "fecha" => "2016"
                        "volumen" => "27"
                        "paginaInicial" => "443"
                        "paginaFinal" => "447"
                      ]
                    ]
                  ]
                ]
              ]
            ]
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              "identificador" => "bib0130"
              "etiqueta" => "9"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Fototerapia en la poblaci&#243;n de Alicante&#58; caracter&#237;sticas epidemiol&#243;gicas y cl&#237;nicas&#44; an&#225;lisis de la respuesta&#44; efectos secundarios y riesgo de carcinog&#233;nesis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "L&#46; Cuesta-Montero"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Libro" => array:3 [
                        "fecha" => "2014"
                        "editorial" => "Universidad Miguel Hern&#225;ndez"
                        "editorialLocalizacion" => "Alicante"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            9 => array:3 [
              "identificador" => "bib0135"
              "etiqueta" => "10"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Documento de consenso sobre fototerapia&#58; terapias PUVA y UVB de banda estrecha"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "J&#46;M&#46; Carrascosa"
                            1 => "J&#46; Gardeaz&#225;bal"
                            2 => "A&#46; P&#233;rez-Ferriols"
                            3 => "A&#46; Alomar"
                            4 => "P&#46; Manrique"
                            5 => "M&#46; Jones-Caballero"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Actas Dermo-sifiliogr&#225;ficas&#46;"
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                        "volumen" => "96"
                        "paginaInicial" => "635"
                        "paginaFinal" => "658"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16476315"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
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              "identificador" => "bib0140"
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                0 => array:3 [
                  "comentario" => "Available from&#58; https&#47;&#47;catalog&#46;hathitrust&#46;org&#47;Record&#47;000495547"
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Cancer mortality for selected sites in 24 countries"
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                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "M&#46; Segi"
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                            2 => "Daigaku"
                            3 => "Nippon Taigan"
                            4 => "Kyokai"
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                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Libro" => array:3 [
                        "fecha" => "1960"
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                        "editorialLocalizacion" => "Sendai"
                      ]
                    ]
                  ]
                ]
              ]
            ]
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              "identificador" => "bib0145"
              "etiqueta" => "12"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Incidence of skin cancers in 3867 patients treated with narrow-band ultraviolet B phototherapy"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "R&#46;M&#46;R&#46; Hearn"
                            1 => "A&#46;C&#46; Kerr"
                            2 => "K&#46;F&#46; Rahim"
                            3 => "J&#46; Ferguson"
                            4 => "R&#46;S&#46; Dawe"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1111/j.1365-2133.2008.08776.x"
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                        "tituloSerie" => "Br J Dermatol&#46;"
                        "fecha" => "2008"
                        "volumen" => "159"
                        "paginaInicial" => "931"
                        "paginaFinal" => "935"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18834483"
                            "web" => "Medline"
                          ]
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                      ]
                    ]
                  ]
                ]
              ]
            ]
            12 => array:3 [
              "identificador" => "bib0150"
              "etiqueta" => "13"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The photocarcinogenic risk of narrowband UVB &#40;TL-01&#41; phototherapy&#58; early follow-up data"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
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                            1 => "I&#46;K&#46; Crombie"
                            2 => "R&#46;S&#46; Dawe"
                            3 => "S&#46;H&#46; Ibbotson"
                            4 => "J&#46; Ferguson"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1111/j.1365-2133.2005.06537.x"
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                        "tituloSerie" => "Br J Dermatol&#46;"
                        "fecha" => "2005"
                        "volumen" => "152"
                        "paginaInicial" => "755"
                        "paginaFinal" => "757"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15840109"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
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              "etiqueta" => "14"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "No evidence for increased skin cancer risk in psoriasis patients treated with broadband or narrowband UVB phototherapy&#58; a first retrospective study"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "M&#46; Weischer"
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                            2 => "F&#46; Eberhard"
                            3 => "M&#46; R&#246;cken"
                            4 => "M&#46; Berneburg"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1080/00015550410026948"
                      "Revista" => array:6 [
                        "tituloSerie" => "Acta Derm Venereol&#46;"
                        "fecha" => "2004"
                        "volumen" => "84"
                        "paginaInicial" => "370"
                        "paginaFinal" => "374"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15370703"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
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              "identificador" => "bib0160"
              "etiqueta" => "15"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "&#91;Non-melanoma skin cancer&#58; incidence time trends analysis in Girona Spain&#44; 1994-2007&#93;"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "N&#46; Vilar-Coromina"
                            1 => "J&#46; Mir&#243;-Queralt"
                            2 => "A&#46; Cano-Bautista"
                            3 => "L&#46; Vilardell-Gil"
                            4 => "P&#46; Torres Babi&#233;"
                            5 => "R&#46; Marcos-Gragera"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.medcli.2011.03.023"
                      "Revista" => array:6 [
                        "tituloSerie" => "Med Clin &#40;Barc&#41;&#46;"
                        "fecha" => "2011"
                        "volumen" => "137"
                        "paginaInicial" => "145"
                        "paginaFinal" => "151"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/21601891"
                            "web" => "Medline"
                          ]
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                      ]
                    ]
                  ]
                ]
              ]
            ]
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              "identificador" => "bib0165"
              "etiqueta" => "16"
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                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Actinic Keratosis&#46; Basal Cell Carcinoma and Squamous Cell Carcinoma"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
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                            1 => "D&#46; Rigel"
                            2 => "E&#46; Wurm"
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                      ]
                    ]
                  ]
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                    0 => array:1 [
                      "LibroEditado" => array:3 [
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              "identificador" => "bib0170"
              "etiqueta" => "17"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Photocarcinogenic risk of narrowband ultraviolet B &#40;TL-01&#41; phototherapy&#58; early follow-up data"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "R&#46;J&#46; Black"
                            1 => "A&#46;T&#46; Gavin"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
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                        "tituloSerie" => "Br J Dermatol&#46;"
                        "fecha" => "2006"
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                        "paginaFinal" => "567"
                        "link" => array:1 [
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