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Ferrándiz-Pulido" "autores" => array:1 [ 0 => array:2 [ "nombre" => "C." "apellidos" => "Ferrándiz-Pulido" ] ] ] ] ] "idiomaDefecto" => "es" "Traduccion" => array:1 [ "en" => array:9 [ "pii" => "S1578219018300398" "doi" => "10.1016/j.adengl.2018.02.022" "estado" => "S300" "subdocumento" => "" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1578219018300398?idApp=UINPBA000044" ] ] "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0001731017306750?idApp=UINPBA000044" "url" => "/00017310/0000010900000003/v1_201804020403/S0001731017306750/v1_201804020403/es/main.assets" ] ] "itemSiguiente" => array:19 [ "pii" => "S1578219018300052" "issn" => "15782190" "doi" => "10.1016/j.adengl.2018.02.003" "estado" => "S300" "fechaPublicacion" => "2018-04-01" "aid" => "1827" "copyright" => "Elsevier España, S.L.U. and AEDV" "documento" => "article" "crossmark" => 1 "subdocumento" => "sco" "cita" => "Actas Dermosifiliogr. 2018;109:202-6" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:2 [ "total" => 61 "HTML" => 61 ] "en" => array:11 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Opinion Article</span>" "titulo" => "Translation and Cross-Cultural Adaptation of Health Assessment Tools" "tienePdf" => "en" "tieneTextoCompleto" => "en" "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "202" "paginaFinal" => "206" ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Proceso de traducción y adaptación cultural de instrumentos de medición en salud" ] ] "contieneTextoCompleto" => array:1 [ "en" => true ] "contienePdf" => array:1 [ "en" => true ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0005" "etiqueta" => "Figure 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 1501 "Ancho" => 3082 "Tamanyo" => 250606 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Steps in the translation and cultural adaptation of a clinical measurement tool. Adapted from Beaton et al.<a class="elsevierStyleCrossRef" href="#bib0125"><span class="elsevierStyleSup">9</span></a></p>" ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "S. Ortiz-Gutiérrez, A. Cruz-Avelar" "autores" => array:2 [ 0 => array:2 [ "nombre" => "S." "apellidos" => "Ortiz-Gutiérrez" ] 1 => array:2 [ "nombre" => "A." "apellidos" => "Cruz-Avelar" ] ] ] ] ] "idiomaDefecto" => "en" "Traduccion" => array:1 [ "es" => array:9 [ "pii" => "S0001731017305616" "doi" => "10.1016/j.ad.2017.09.012" "estado" => "S300" "subdocumento" => "" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0001731017305616?idApp=UINPBA000044" ] ] "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1578219018300052?idApp=UINPBA000044" "url" => "/15782190/0000010900000003/v1_201804020430/S1578219018300052/v1_201804020430/en/main.assets" ] "itemAnterior" => array:19 [ "pii" => "S1578219018300209" "issn" => "15782190" "doi" => "10.1016/j.adengl.2018.02.018" "estado" => "S300" "fechaPublicacion" => "2018-04-01" "aid" => "1857" "copyright" => "Elsevier España, S.L.U. and AEDV" "documento" => "simple-article" "crossmark" => 1 "subdocumento" => "cor" "cita" => "Actas Dermosifiliogr. 2018;109:200" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:2 [ "total" => 65 "formatos" => array:2 [ "HTML" => 63 "PDF" => 2 ] ] "en" => array:10 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Commentaries</span>" "titulo" => "Imiquimoid 5%: In Pursuit of New Treatment Regimens for Actinic Keratosis" "tienePdf" => "en" "tieneTextoCompleto" => "en" "paginas" => array:1 [ 0 => array:1 [ "paginaInicial" => "200" ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Búsqueda de nuevas pautas terapéuticas de imiquimod 5% para el tratamiento de las queratosis actínicas" ] ] "contieneTextoCompleto" => array:1 [ "en" => true ] "contienePdf" => array:1 [ "en" => true ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "R. Salido Vallejo" "autores" => array:1 [ 0 => array:2 [ "nombre" => "R." "apellidos" => "Salido Vallejo" ] ] ] ] ] "idiomaDefecto" => "en" "Traduccion" => array:1 [ "es" => array:9 [ "pii" => "S0001731017306282" "doi" => "10.1016/j.ad.2017.11.005" "estado" => "S300" "subdocumento" => "" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0001731017306282?idApp=UINPBA000044" ] ] "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1578219018300209?idApp=UINPBA000044" "url" => "/15782190/0000010900000003/v1_201804020430/S1578219018300209/v1_201804020430/en/main.assets" ] "en" => array:12 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Commentaries</span>" "titulo" => "Imatinib: A New Tool for the Management of Chronic Sclerodermatous Graft-vs-Host Disease" "tieneTextoCompleto" => true "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "200" "paginaFinal" => "201" ] ] "autores" => array:1 [ 0 => array:3 [ "autoresLista" => "C. Ferrándiz-Pulido" "autores" => array:1 [ 0 => array:3 [ "nombre" => "C." "apellidos" => "Ferrándiz-Pulido" "email" => array:1 [ 0 => "40879cfp@comb.cat" ] ] ] "afiliaciones" => array:1 [ 0 => array:2 [ "entidad" => "Servicio de Dermatología, Hospital Universitario Vall d’Hebron, Barcelona Sección: Comentario Editorial" "identificador" => "aff0005" ] ] ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Imatinib: Una nueva herramienta para el manejo de la enfermedad del injerto contra el hospedador crónica esclerodermiforme" ] ] "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">The therapeutic management of chronic sclerodermatous graft-vs-host disease (GVHD) is challenging because, apart from systemic corticosteroids, no treatments have shown clear benefits in terms of long-term effectiveness or tolerability. In this retrospective study, the authors describe their experience with the use of imatinib to treat chronic sclerodermatous GVHD in 18 patients who did not respond to systemic corticosteroids. The majority of patients (83%) responded at least partially and the treatment also permitted corticosteroid tapering in a high proportion of cases (78%). Imatinib is a potent tyrosine-kinase inhibitor that is used in GVHD because of its dual inhibitory activity against platelet-derived growth factor receptor and transforming growth factor-β. There is no evidence from clinical trials to support the use of imatinib in chronic sclerodermatous GVHD. This study, however, adds to data from other series in which imatinib has improved symptoms and achieved response rates of between 50% and 79%, with lower rates observed in older patients and patients with more advanced lung disease.<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a> Imatinib is also a relatively well-tolerated drug associated with low levels of discontinuation due to adverse effects. Despite the retrospective nature of this study, its results add to the body of evidence on the effectiveness of imatinib in the management of chronic sclerodermatous GVHD. Prospective studies, however, are needed to confirm these preliminary results.</p></span>" "pdfFichero" => "main.pdf" "tienePdf" => true "NotaPie" => array:1 [ 0 => array:2 [ "etiqueta" => "☆" "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Please cite this article as: Ferrándiz-Pulido C. matinib: una nueva herramienta para el manejo de la enfermedad del injerto contra el hospedador crónica esclerodermiforme. Actas Dermosifiliogr. 2018;109:200–201.</p>" ] ] "bibliografia" => array:2 [ "titulo" => "Reference" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0015" "bibliografiaReferencia" => array:1 [ 0 => array:3 [ "identificador" => "bib0005" "etiqueta" => "1" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Treatment of chronic graft-versus-host disease in 2011" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "Y. Inamoto" 1 => "M.E.D. Flowers" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1097/MOH.0b013e32834ba87d" "Revista" => array:6 [ "tituloSerie" => "Curr Opin Hematol." "fecha" => "2011" "volumen" => "18" "paginaInicial" => "414" "paginaFinal" => "420" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/21912257" "web" => "Medline" ] ] ] ] ] ] ] ] ] ] ] ] ] "idiomaDefecto" => "en" "url" => "/15782190/0000010900000003/v1_201804020430/S1578219018300398/v1_201804020430/en/main.assets" "Apartado" => array:4 [ "identificador" => "66476" "tipo" => "SECCION" "en" => array:2 [ "titulo" => "Commentaries" "idiomaDefecto" => true ] "idiomaDefecto" => "en" ] "PDF" => "https://static.elsevier.es/multimedia/15782190/0000010900000003/v1_201804020430/S1578219018300398/v1_201804020430/en/main.pdf?idApp=UINPBA000044&text.app=https://actasdermo.org/" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1578219018300398?idApp=UINPBA000044" ]
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