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RF - Drug-Induced Eruptive Melanocytic Nevi
FR - Nevus melanocíticos eruptivos asociados a medicamentos
P. García-Montero
, J.F. Millán-Cayetano, C. García-Harana, J. del Boz
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Departamento de Dermatología, Hospital Costa del Sol, Marbella, Málaga, Spain
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García-Montero, J.F. Millán-Cayetano, C. García-Harana, J. del Boz" "autores" => array:4 [ 0 => array:4 [ "nombre" => "P." "apellidos" => "García-Montero" "email" => array:1 [ 0 => "garciamonteropablo@gmail.com" ] "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">*</span>" "identificador" => "cor0005" ] ] ] 1 => array:2 [ "nombre" => "J.F." "apellidos" => "Millán-Cayetano" ] 2 => array:2 [ "nombre" => "C." "apellidos" => "García-Harana" ] 3 => array:2 [ "nombre" => "J." "apellidos" => "del Boz" ] ] "afiliaciones" => array:1 [ 0 => array:2 [ "entidad" => "Departamento de Dermatología, Hospital Costa del Sol, Marbella, Málaga, Spain" "identificador" => "aff0005" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "⁎" "correspondencia" => "Corresponding author." ] ] ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "FR - Nevus melanocíticos eruptivos asociados a medicamentos" ] ] "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">The prestigious <span class="elsevierStyleItalic">Journal of the American Academy of Dermatology</span> recently published an interesting article that presents the results of an extensive review of the literature on eruptive melanocytic nevi that develop in association with medication use.<a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">1</span></a> This type of lesion has historically been associated with severe blistering diseases (epidermolysis bullosa, toxic drug reactions, etc.) and with conditions leading to immunodeficiency (renal transplantation, bone marrow transplantation, malignancy, AIDS, etc.).<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">2</span></a></p><p id="par0010" class="elsevierStylePara elsevierViewall">In order to differentiate eruptive nevi associated with medications (ENAM) from acquired melanocytic nevi, the authors propose the following criteria:<ul class="elsevierStyleList" id="lis0005"><li class="elsevierStyleListItem" id="lsti0005"><span class="elsevierStyleLabel">-</span><p id="par0015" class="elsevierStylePara elsevierViewall">Development of more than 5 palmoplantar melanocytic nevi at any age.</p></li><li class="elsevierStyleListItem" id="lsti0010"><span class="elsevierStyleLabel">-</span><p id="par0020" class="elsevierStylePara elsevierViewall">Development of more than 10 melanocytic nevi bodywide outside of puberty or pregnancy.</p></li><li class="elsevierStyleListItem" id="lsti0015"><span class="elsevierStyleLabel">-</span><p id="par0025" class="elsevierStylePara elsevierViewall">Development of more than 20 melanocytic nevi bodywide during puberty or pregnancy.</p></li></ul></p><p id="par0030" class="elsevierStylePara elsevierViewall">A diagnosis of ENAM is established when the patient meets 1 or more of these criteria in the last 6 months and there is a temporal relationship with the use of a particular medication. The authors also propose the classification of ENAMs according to the implicated medication (<a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a>).</p><elsevierMultimedia ident="tbl0005"></elsevierMultimedia><p id="par0035" class="elsevierStylePara elsevierViewall">Using these criteria, the authors identified a total of 66 reported cases of ENAM. Thiopurines, azathioprine, and 6-mercaptopurine were the drugs most frequently associated with ENAM (34.8% of cases). Cases of ENAM in the last 10 years account for 66.2% of all cases reported in the literature, and 44.2% of these cases are associated with biologic therapies. No differences between sexes were identified and a certain predilection for lighter skin types was found. The lesions appear weeks or months after medication use begins and usually present as 1- to 3-mm light or dark brown macules. Dermoscopically, the lesions are usually characterized by globules arranged symmetrically at the periphery.<a class="elsevierStyleCrossRef" href="#bib0040"><span class="elsevierStyleSup">3</span></a> Histologically, the lesions appear as compound nevi. ENAMs are more likely than acquired melanocytic nevi to be located on the palms and soles.<a class="elsevierStyleCrossRef" href="#bib0045"><span class="elsevierStyleSup">4</span></a></p><p id="par0040" class="elsevierStylePara elsevierViewall">The pathogenesis of ENAM and the potential risk of development or transformation to melanoma are not completely understood.<a class="elsevierStyleCrossRef" href="#bib0050"><span class="elsevierStyleSup">5</span></a> It appears logical that immunosuppression could play an important role in the development of ENAM and larger numbers of nevi could be a risk factor for melanoma. However, further research is needed in order to provide more evidence. For now, in patients diagnosed with ENAM, the authors recommend annual follow-up visits and identification of the drug responsible. They also suggest that alternative treatments be considered in patients with a personal or family history of melanoma.</p><p id="par0045" class="elsevierStylePara elsevierViewall">The number of patients on immunosuppressive medications is on the rise and the subgroup receiving biologics is growing. Although ENAM is rare, the incidence of this entity is expected to rise in the coming years. An understanding of this causal relationship will favor early diagnosis, thereby minimizing the degree of uncertainty for both patient and physician and avoiding unnecessary complementary tests.</p></span>" "pdfFichero" => "main.pdf" "tienePdf" => true "PalabrasClave" => array:1 [ "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Keywords" "identificador" => "xpalclavsec888226" "palabras" => array:4 [ 0 => "Eruptive melanocytic nevi" 1 => "Drugs" 2 => "Biologic therapies" 3 => "Adverse effects" ] ] ] ] "NotaPie" => array:1 [ 0 => array:2 [ "etiqueta" => "☆" "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Please cite this article as: García-Montero P, Millán-Cayetano JF, García-Harana C, del Boz J. FR - Nevus melanocíticos eruptivos asociados a medicamentos. Actas Dermosifiliogr. 2017;108:775–776.</p>" ] ] "multimedia" => array:1 [ 0 => array:8 [ "identificador" => "tbl0005" "etiqueta" => "Table 1" "tipo" => "MULTIMEDIATABLA" "mostrarFloat" => true "mostrarDisplay" => false "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at1" "detalle" => "Table " "rol" => "short" ] ] "tabla" => array:2 [ "leyenda" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Abbreviation: ENAM, eruptive nevi associated with medications.</p>" "tablatextoimagen" => array:1 [ 0 => array:2 [ "tabla" => array:1 [ 0 => """ <table border="0" frame="\n \t\t\t\t\tvoid\n \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="table-head " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Types of ENAM \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Drugs Involved \t\t\t\t\t\t\n \t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Ia. Nonbiologic immunosuppressants \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Azathioprine, 6-mercaptopurine, corticosteroids, cyclosporin, and methotrexate \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Ib. Biologic immunosuppressants \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Etanercept, alefacept, infliximab, and rituximab \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">IIa. Nonbiologic chemotherapeutics \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Capecitabine, interferon alfa-2b, cyclophosphamide, and octreotide \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">IIb. Biologic chemotherapeutics \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Vemurafenib, encorafenib, sorafenib, sunitinib, erlotinib, regorafenib, and rituximab \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">III. Melanocyte stimulators \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Melanotan <span class="elsevierStyleSmallCaps">I</span> and <span class="elsevierStyleSmallCaps">II</span> and corticotrophin \t\t\t\t\t\t\n \t\t\t\t</td></tr></tbody></table> """ ] "imagenFichero" => array:1 [ 0 => "xTab1527677.png" ] ] ] ] "descripcion" => array:1 [ "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Types of Eruptive Nevi Associated With Medication and Drugs Involved.</p>" ] ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:5 [ 0 => array:3 [ "identificador" => "bib0030" "etiqueta" => "1" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Eruptive nevi associated with medications (ENAMs)" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "B.M. Perry" 1 => "A. Nguyen" 2 => "B.L. Desmond" 3 => "C.M. Blattner" 4 => "R.S. Thomas" 5 => "R.J. Young" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.jaad.2016.04.064" "Revista" => array:6 [ "tituloSerie" => "J Am Acad Dermatol" "fecha" => "2016" "volumen" => "75" "paginaInicial" => "1045" "paginaFinal" => "1052" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/27241804" "web" => "Medline" ] ] ] ] ] ] ] ] 1 => array:3 [ "identificador" => "bib0035" "etiqueta" => "2" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Eruptive dysplastic nevi following melanotan use" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "L. Hueso-Gabriel" 1 => "L. Mahiques Santos" 2 => "L. Terrádez Mas" 3 => "N. Santonja López" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.ad.2011.10.001" "Revista" => array:6 [ "tituloSerie" => "Actas Dermosifiliogr" "fecha" => "2012" "volumen" => "103" "paginaInicial" => "329" "paginaFinal" => "331" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/22425244" "web" => "Medline" ] ] ] ] ] ] ] ] 2 => array:3 [ "identificador" => "bib0040" "etiqueta" => "3" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Dermoscopic features of eruptive melanocytic naevi in an adult patient receiving immunosuppressive therapy for Crohn's disease" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "A. Belloni Fortina" 1 => "S. Piaserico" 2 => "E. Zattra" 3 => "M. Alaibac" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Melanoma Res" "fecha" => "2005" "volumen" => "15" "paginaInicial" => "223" "paginaFinal" => "224" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15917707" "web" => "Medline" ] ] ] ] ] ] ] ] 3 => array:3 [ "identificador" => "bib0045" "etiqueta" => "4" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Immunosuppression and melanocyte proliferation" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "E. Zattra" 1 => "A.B. Fortina" 2 => "M. Bordignon" 3 => "S. Piaserico" 4 => "M. Alaibac" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1097/CMR.0b013e328322fc20" "Revista" => array:6 [ "tituloSerie" => "Melanoma Res" "fecha" => "2009" "volumen" => "19" "paginaInicial" => "63" "paginaFinal" => "68" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19194340" "web" => "Medline" ] ] ] ] ] ] ] ] 4 => array:3 [ "identificador" => "bib0050" "etiqueta" => "5" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Eruptive nevi of the palms and soles" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "J. Woodhouse" 1 => "E.V. 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| año/Mes | Html | Total | |
|---|---|---|---|
| 2024 Noviembre | 16 | 6 | 22 |
| 2024 Octubre | 102 | 36 | 138 |
| 2024 Septiembre | 129 | 23 | 152 |
| 2024 Agosto | 134 | 49 | 183 |
| 2024 Julio | 137 | 39 | 176 |
| 2024 Junio | 148 | 36 | 184 |
| 2024 Mayo | 102 | 23 | 125 |
| 2024 Abril | 97 | 30 | 127 |
| 2024 Marzo | 106 | 32 | 138 |
| 2024 Febrero | 86 | 27 | 113 |
| 2024 Enero | 103 | 37 | 140 |
| 2023 Diciembre | 63 | 25 | 88 |
| 2023 Noviembre | 90 | 23 | 113 |
| 2023 Octubre | 77 | 20 | 97 |
| 2023 Septiembre | 97 | 35 | 132 |
| 2023 Agosto | 61 | 21 | 82 |
| 2023 Julio | 79 | 37 | 116 |
| 2023 Junio | 80 | 28 | 108 |
| 2023 Mayo | 56 | 23 | 79 |
| 2023 Abril | 67 | 26 | 93 |
| 2023 Marzo | 44 | 24 | 68 |
| 2023 Febrero | 53 | 26 | 79 |
| 2023 Enero | 37 | 29 | 66 |
| 2022 Diciembre | 56 | 32 | 88 |
| 2022 Noviembre | 25 | 26 | 51 |
| 2022 Octubre | 45 | 24 | 69 |
| 2022 Septiembre | 35 | 36 | 71 |
| 2022 Agosto | 32 | 45 | 77 |
| 2022 Julio | 47 | 57 | 104 |
| 2022 Junio | 46 | 28 | 74 |
| 2022 Mayo | 55 | 59 | 114 |
| 2022 Abril | 55 | 47 | 102 |
| 2022 Marzo | 62 | 61 | 123 |
| 2022 Febrero | 48 | 26 | 74 |
| 2022 Enero | 54 | 38 | 92 |
| 2021 Diciembre | 45 | 47 | 92 |
| 2021 Noviembre | 63 | 50 | 113 |
| 2021 Octubre | 149 | 63 | 212 |
| 2021 Septiembre | 59 | 40 | 99 |
| 2021 Agosto | 50 | 43 | 93 |
| 2021 Julio | 42 | 39 | 81 |
| 2021 Junio | 36 | 32 | 68 |
| 2021 Mayo | 39 | 50 | 89 |
| 2021 Abril | 99 | 73 | 172 |
| 2021 Marzo | 74 | 35 | 109 |
| 2021 Febrero | 60 | 34 | 94 |
| 2021 Enero | 40 | 25 | 65 |
| 2020 Diciembre | 41 | 17 | 58 |
| 2020 Noviembre | 35 | 25 | 60 |
| 2020 Octubre | 37 | 13 | 50 |
| 2020 Septiembre | 38 | 22 | 60 |
| 2020 Agosto | 47 | 26 | 73 |
| 2020 Julio | 28 | 15 | 43 |
| 2020 Junio | 51 | 36 | 87 |
| 2020 Mayo | 27 | 20 | 47 |
| 2020 Abril | 30 | 16 | 46 |
| 2020 Marzo | 32 | 16 | 48 |
| 2020 Febrero | 7 | 0 | 7 |
| 2020 Enero | 4 | 0 | 4 |
| 2019 Diciembre | 7 | 0 | 7 |
| 2019 Noviembre | 6 | 0 | 6 |
| 2019 Septiembre | 8 | 0 | 8 |
| 2019 Agosto | 4 | 0 | 4 |
| 2019 Julio | 4 | 0 | 4 |
| 2019 Junio | 5 | 0 | 5 |
| 2019 Mayo | 5 | 0 | 5 |
| 2019 Abril | 2 | 0 | 2 |
| 2019 Marzo | 4 | 0 | 4 |
| 2019 Febrero | 2 | 0 | 2 |
| 2019 Enero | 2 | 0 | 2 |
| 2018 Diciembre | 4 | 0 | 4 |
| 2018 Octubre | 6 | 0 | 6 |
| 2018 Septiembre | 4 | 0 | 4 |
| 2018 Mayo | 0 | 1 | 1 |
| 2018 Febrero | 46 | 6 | 52 |
| 2018 Enero | 38 | 6 | 44 |
| 2017 Diciembre | 63 | 13 | 76 |
| 2017 Noviembre | 42 | 8 | 50 |
| 2017 Octubre | 125 | 39 | 164 |
| 2017 Septiembre | 3 | 6 | 9 |
| 2017 Agosto | 6 | 8 | 14 |
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