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On examination&#44; infiltrated erythematous plaques with well-defined borders were observed on the lower eyelid of the right eye and right cheek &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>A&#41;&#44; and other smaller plaques on the tip of the nose and border of the right nares &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>B&#41;&#46; Histology revealed a dense infiltrate of lymphocytic with atypical morphological features and an angiocentric distribution &#40;<a class="elsevierStyleCrossRef" href="#fig0010">Fig&#46; 2</a>&#44; A and B&#41;&#46; On immunohistochemistry&#44; there were T lymphocytes positive for CD3&#44; CD56&#44; and granzyme B &#40;<a class="elsevierStyleCrossRef" href="#fig0015">Fig&#46; 3</a>&#44; A-C&#41;&#44; and the presence of Epstein-Barr virus &#40;EBV&#41; &#40;<a class="elsevierStyleCrossRef" href="#fig0015">Fig&#46; 3</a>D&#41; was confirmed on EBER &#40;EBV encoded RNAs&#41; stain&#46; Complete blood count&#44; biochemistry&#44; and bone marrow biopsy were normal&#46; Computed tomography revealed a hypervascular tumor affecting the right orbit&#44; nose&#44; and cheek&#46; Based on these findings we made a diagnosis of stage IA extranodal NKTCL&#44; nasal-type&#46; Despite the early diagnosis and treatment with radiotherapy and chemotherapy&#44; the patient died a year later&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><elsevierMultimedia ident="fig0010"></elsevierMultimedia><elsevierMultimedia ident="fig0015"></elsevierMultimedia><p id="par0015" class="elsevierStylePara elsevierViewall">The term extranodal NKTCL&#44; nasal-type&#44; was first used in the year 2001 by the World Health Organization&#44; replacing the term angiocentric lymphoma&#46;<a class="elsevierStyleCrossRef" href="#bib0080"><span class="elsevierStyleSup">6</span></a> Other names by which this disease has been known in the past include lethal midline granuloma&#44; necrotizing midfacial lesion&#44; polymorphous reticulosis&#44; 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of infectious &#40;<span class="elsevierStyleItalic">Leishmania</span>&#44; paracoccidioidomycosis&#44; histoplasmosis&#44; lepromatous leprosy&#44; mycobacteriosis&#44; mucormycosis&#41;&#44; autoimmune &#40;Wegener granulomatosis&#44; lupus&#41;&#44; or toxic &#40;cocaine sniffing&#41; etiology&#46;<a class="elsevierStyleCrossRefs" href="#bib0075"><span class="elsevierStyleSup">5&#44;8</span></a></p><p id="par0025" class="elsevierStylePara elsevierViewall">The etiology of this lymphoma is unknown&#44; but the presence of EBV is an almost constant finding&#44; with detection of viral RNA in the diseased lymphocytes by in situ hybridization using probes marked with Epstein-Barr-encoded small RNAs &#40;EBER&#41;&#59; this would suggest a major etiologic and pathogenic role for this virus in the development of this disease&#46;<a class="elsevierStyleCrossRefs" href="#bib0070"><span class="elsevierStyleSup">4&#44;5&#44;8</span></a> The majority of cells that make up this neoplasm are natural killer cells and peripheral T cells with a cytotoxic phenotype&#46; Histologically&#44; dense infiltrates of atypical lymphocytes are observed in the dermis and subcutaneous cellular tissue&#46; These are small-to-medium sized cells with pale cytoplasm and atypical nuclei with clumped chromatin and irregular borders&#46; There is marked angiocentricity and angiodestruction associated with extensive necrosis&#46; Immunohistochemically&#44; the neoplastic cells are positive for CD2&#44; cytoplasmic CD3&#44; CD56&#44; and cytotoxic proteins &#40;granzyme B&#44; T-cell intracellular antigen &#91;TIA&#93;-1&#44; and perforin&#41;&#46;<a class="elsevierStyleCrossRefs" href="#bib0055"><span class="elsevierStyleSup">1&#8211;5</span></a></p><p id="par0030" class="elsevierStylePara elsevierViewall">Treatment of NKTCL is based on radiotherapy for localized disease&#44; though this is usually combined with chemotherapy&#46; If the patient is initially managed using chemotherapy&#44; palliative or coadjuvant radiotherapy is recommended&#46; The poor response to chemotherapy may be due to the expression of multidrug resistance genes&#46; Allogenic bone marrow transplant has been proposed in selected patients&#46; Because of the intrinsically aggressive nature of this type of lymphoma&#44; treatment does not reduce mortality in the majority of cases&#46;<a class="elsevierStyleCrossRefs" href="#bib0095"><span class="elsevierStyleSup">9&#44;10</span></a></p><p id="par0035" class="elsevierStylePara elsevierViewall">Although this disease is rare in our setting&#44; extranodal NKTCL&#44; nasal-type&#44; must be included in the differential diagnosis of skin lesions that affect the midfacial region and present with nasal symptoms&#44; in order to avoid delayed diagnosis and treatment&#46;</p><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0005">Conflicts of Interest</span><p id="par0040" class="elsevierStylePara elsevierViewall">The authors declare that they have no conflicts of interest&#46;</p></span></span>"
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Case and Research Letter
Nasal-Type Extranodal Natural Killer T-Cell Lymphoma
Linfoma de células NK/T extranodal nasal
F. Moreno-Suáreza,
Autor para correspondencia
fatimacordoba@hotmail.com

Corresponding author.
, P. Bautista Martíneza, F. Jiménez Burgosb
a Servicio de Dermatología, Hospital Santa Bárbara, Puertollano, Ciudad Real, Spain
b Servicio de Anatomía Patológica, Hospital Santa Bárbara, Puertollano, Ciudad Real, Spain
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On examination&#44; infiltrated erythematous plaques with well-defined borders were observed on the lower eyelid of the right eye and right cheek &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>A&#41;&#44; and other smaller plaques on the tip of the nose and border of the right nares &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>B&#41;&#46; Histology revealed a dense infiltrate of lymphocytic with atypical morphological features and an angiocentric distribution &#40;<a class="elsevierStyleCrossRef" href="#fig0010">Fig&#46; 2</a>&#44; A and B&#41;&#46; On immunohistochemistry&#44; there were T lymphocytes positive for CD3&#44; CD56&#44; and granzyme B &#40;<a class="elsevierStyleCrossRef" href="#fig0015">Fig&#46; 3</a>&#44; A-C&#41;&#44; and the presence of Epstein-Barr virus &#40;EBV&#41; &#40;<a class="elsevierStyleCrossRef" href="#fig0015">Fig&#46; 3</a>D&#41; was confirmed on EBER &#40;EBV encoded RNAs&#41; stain&#46; Complete blood count&#44; biochemistry&#44; and bone marrow biopsy were normal&#46; Computed tomography revealed a hypervascular tumor affecting the right orbit&#44; nose&#44; and cheek&#46; Based on these findings we made a diagnosis of stage IA extranodal NKTCL&#44; nasal-type&#46; Despite the early diagnosis and treatment with radiotherapy and chemotherapy&#44; the patient died a year later&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><elsevierMultimedia ident="fig0010"></elsevierMultimedia><elsevierMultimedia ident="fig0015"></elsevierMultimedia><p id="par0015" class="elsevierStylePara elsevierViewall">The term extranodal NKTCL&#44; nasal-type&#44; was first used in the year 2001 by the World Health Organization&#44; replacing the term angiocentric lymphoma&#46;<a class="elsevierStyleCrossRef" href="#bib0080"><span class="elsevierStyleSup">6</span></a> Other names by which this disease has been known in the past include lethal midline granuloma&#44; necrotizing midfacial lesion&#44; polymorphous reticulosis&#44; angiocentric immunoproliferative lesion&#44; Stewart granuloma&#44; granuloma gangrenescens&#44; gangrenous proliferative rhinitis&#44; and sinonasal lymphoma&#46; Extranodal NKTCL&#44; nasal-type&#44; accounts for 7&#37; to 10&#37; of non-Hodgkin lymphomas in Asia and South America&#44; but only 1&#37; in Europe and North America&#46; It mainly affects individuals in their fifth decade of life and is more prevalent in men&#46; As in our patient&#44; the disease usually presents initially with rhinorrhea or a purulent nasal secretion&#44; progressing subsequently to lesions with a tendency to ulceration and necrosis secondary to infiltration of the surrounding skin&#46;<a class="elsevierStyleCrossRefs" href="#bib0055"><span class="elsevierStyleSup">1&#8211;5</span></a> The prognosis is very poor&#44; even with early diagnosis&#44; as in our patient&#44; with a mean survival of less than 12 months&#46;<a class="elsevierStyleCrossRefs" href="#bib0055"><span class="elsevierStyleSup">1&#44;7</span></a></p><p id="par0020" class="elsevierStylePara elsevierViewall">The differential diagnosis must include entities that affect the facial midline&#44; of infectious &#40;<span class="elsevierStyleItalic">Leishmania</span>&#44; paracoccidioidomycosis&#44; histoplasmosis&#44; lepromatous leprosy&#44; mycobacteriosis&#44; mucormycosis&#41;&#44; autoimmune &#40;Wegener granulomatosis&#44; lupus&#41;&#44; or toxic &#40;cocaine sniffing&#41; etiology&#46;<a class="elsevierStyleCrossRefs" href="#bib0075"><span class="elsevierStyleSup">5&#44;8</span></a></p><p id="par0025" class="elsevierStylePara elsevierViewall">The etiology of this lymphoma is unknown&#44; but the presence of EBV is an almost constant finding&#44; with detection of viral RNA in the diseased lymphocytes by in situ hybridization using probes marked with Epstein-Barr-encoded small RNAs &#40;EBER&#41;&#59; this would suggest a major etiologic and pathogenic role for this virus in the development of this disease&#46;<a class="elsevierStyleCrossRefs" href="#bib0070"><span class="elsevierStyleSup">4&#44;5&#44;8</span></a> The majority of cells that make up this neoplasm are natural killer cells and peripheral T cells with a cytotoxic phenotype&#46; Histologically&#44; dense infiltrates of atypical lymphocytes are observed in the dermis and subcutaneous cellular tissue&#46; These are small-to-medium sized cells with pale cytoplasm and atypical nuclei with clumped chromatin and irregular borders&#46; There is marked angiocentricity and angiodestruction associated with extensive necrosis&#46; Immunohistochemically&#44; the neoplastic cells are positive for CD2&#44; cytoplasmic CD3&#44; CD56&#44; and cytotoxic proteins &#40;granzyme B&#44; T-cell intracellular antigen &#91;TIA&#93;-1&#44; and perforin&#41;&#46;<a class="elsevierStyleCrossRefs" href="#bib0055"><span class="elsevierStyleSup">1&#8211;5</span></a></p><p id="par0030" class="elsevierStylePara elsevierViewall">Treatment of NKTCL is based on radiotherapy for localized disease&#44; though this is usually combined with chemotherapy&#46; If the patient is initially managed using chemotherapy&#44; palliative or coadjuvant radiotherapy is recommended&#46; The poor response to chemotherapy may be due to the expression of multidrug resistance genes&#46; Allogenic bone marrow transplant has been proposed in selected patients&#46; Because of the intrinsically aggressive nature of this type of lymphoma&#44; treatment does not reduce mortality in the majority of cases&#46;<a class="elsevierStyleCrossRefs" href="#bib0095"><span class="elsevierStyleSup">9&#44;10</span></a></p><p id="par0035" class="elsevierStylePara elsevierViewall">Although this disease is rare in our setting&#44; extranodal NKTCL&#44; nasal-type&#44; must be included in the differential diagnosis of skin lesions that affect the midfacial region and present with nasal symptoms&#44; in order to avoid delayed diagnosis and treatment&#46;</p><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0005">Conflicts of Interest</span><p id="par0040" class="elsevierStylePara elsevierViewall">The authors declare that they have no conflicts of interest&#46;</p></span></span>"
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