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The results of antibody testing &#40;antinuclear antibodies&#44; anti-RNP&#44; anti-Jo1&#44; and anti-p155&#41; were negative&#46; Analysis of a skin biopsy specimen revealed vacuolar changes at the dermal-epidermal junction&#44; solitary necrotic keratinocytes&#44; and mucin deposits in the dermis&#46; The electromyogram revealed signs of inflammatory myopathy&#44; and occult underlying neoplasm was ruled out by tumor markers and positron emission tomography and computed tomography imaging&#46; These findings confirmed the diagnosis of dermatomyositis&#44; and treatment was started with intravenous methylprednisolone &#40;1<span class="elsevierStyleHsp" style=""></span>mg&#47;kg&#47;d&#41;&#59; after 5 days&#44; 4 doses of immunoglobulin &#40;1&#46;5<span class="elsevierStyleHsp" style=""></span>g&#47;kg&#47;dose&#41; were added&#44; although there was little improvement&#46; During the following months&#44; the patient&#39;s condition progressed with intense edema affecting the face&#44; neck&#44; and upper extremities &#40;visible on the magnetic resonance image&#41; and myositis &#40;<a class="elsevierStyleCrossRefs" href="#fig0005">Figs&#46; 1&#8211;3</a>&#41;&#46; Therefore&#44; methotrexate was added to the treatment regimen at 2 months&#44; hydroxychloroquine at 4 months&#44; and&#44; given the lack of improvement&#44; rituximab &#40;1<span class="elsevierStyleHsp" style=""></span>g&#41; at 6 months in 2 doses separated by 2 weeks&#46; The response was good&#44; mainly in the skin&#46; During follow-up&#44; occasional thrombocytopenia and anemia &#40;hemoglobin&#44; 10&#46;8<span class="elsevierStyleHsp" style=""></span>g&#47;dL&#59; platelets&#44; 58&#160;000&#47;&#956;L&#41; were recorded&#44; as were increased values for indirect bilirubin &#40;1<span class="elsevierStyleHsp" style=""></span>mg&#47;dL &#91;&#62;<span class="elsevierStyleHsp" style=""></span>0&#46;7&#93;&#41; and lactate dehydrogenase &#40;641<span class="elsevierStyleHsp" style=""></span>IU&#47;L &#91;&#62;<span class="elsevierStyleHsp" style=""></span>385&#93;&#41;&#46; These findings were compatible with Evans syndrome with dermatomyositis occurring alongside worsening muscle enzyme values&#46; However&#44; as the patient was receiving treatment with corticosteroids&#44; it was impossible to perform the Coombs test to confirm this associated autoimmune etiology&#46; Similarly&#44; it was not possible to rule out other etiologies&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><elsevierMultimedia ident="fig0010"></elsevierMultimedia><elsevierMultimedia ident="fig0015"></elsevierMultimedia><p id="par0015" class="elsevierStylePara elsevierViewall">Dermatomyositis is an autoimmune disease that mainly affects the skin and muscle&#46; It has traditionally taken the form of mild periorbital edema accompanied by heliotrope rash&#46; However&#44; edematous dermatomyositis involves more extensive swelling&#46; It is also a rare clinical variant of the condition&#44; with only 23 cases reported in the literature&#46;<a class="elsevierStyleCrossRef" href="#bib0055"><span class="elsevierStyleSup">1</span></a> The etiology and pathogenesis remain unclear&#44; although some authors have pointed to intense inflammatory activity with activation and deposition of complement&#44; leading to vascular disease with muscle microinfarcts that in turn increase vascular permeability&#46;<a class="elsevierStyleCrossRefs" href="#bib0055"><span class="elsevierStyleSup">1&#8211;5</span></a> This manifests clinically as edema affecting muscle and&#47;or subcutaneous tissue&#44; with or without pitting&#46; Age at presentation is variable&#44;<a class="elsevierStyleCrossRefs" href="#bib0055"><span class="elsevierStyleSup">1&#44;2&#44;6</span></a> with most adult cases occurring in women&#46;<a class="elsevierStyleCrossRef" href="#bib0055"><span class="elsevierStyleSup">1</span></a> Edema mainly affects the upper extremities&#44; although it may be generalized<a class="elsevierStyleCrossRefs" href="#bib0070"><span class="elsevierStyleSup">4&#44;6&#44;7</span></a>&#59; cases of local edema have also been reported&#46;<a class="elsevierStyleCrossRefs" href="#bib0060"><span class="elsevierStyleSup">2&#44;8&#44;9</span></a> Edematous dermatomyositis usually progresses more rapidly than classic dermatomyositis&#46;<a class="elsevierStyleCrossRef" href="#bib0075"><span class="elsevierStyleSup">5</span></a> Edema usually develops after skin involvement&#44; although it may also be the initial presentation<a class="elsevierStyleCrossRef" href="#bib0080"><span class="elsevierStyleSup">6</span></a>&#59; there have even been reports of edematous dermatomyositis with no other cutaneous findings&#46;<a class="elsevierStyleCrossRef" href="#bib0075"><span class="elsevierStyleSup">5</span></a> Muscle involvement and dysphagia are frequently associated with edematous dermatomyositis&#44;<a class="elsevierStyleCrossRefs" href="#bib0055"><span class="elsevierStyleSup">1&#44;4</span></a> as observed in the case we report&#46;</p><p id="par0020" class="elsevierStylePara elsevierViewall">It remains unclear whether this clinical presentation of dermatomyositis implies a greater risk of neoplasm<a class="elsevierStyleCrossRef" href="#bib0075"><span class="elsevierStyleSup">5</span></a>&#59; according to a recently published literature review&#44; the risk of neoplasm was recorded in fewer than 30&#37; of cases &#40;6 of 23 cases reviewed&#41;&#46;<a class="elsevierStyleCrossRef" href="#bib0055"><span class="elsevierStyleSup">1</span></a></p><p id="par0025" class="elsevierStylePara elsevierViewall">Before a diagnosis of edematous dermatomyositis can be confirmed&#44; it is important to rule out other&#44; secondary causes of edema&#44;<a class="elsevierStyleCrossRef" href="#bib0055"><span class="elsevierStyleSup">1</span></a> such as kidney&#44; heart&#44; and thyroid disease&#44; as well as hypoproteinemia&#46; Treatment of edematous dermatomyositis should be intensive and early&#44; given the potentially severe nature of the symptoms<a class="elsevierStyleCrossRefs" href="#bib0055"><span class="elsevierStyleSup">1&#44;4&#44;5&#44;9&#44;10</span></a> and the probable poorer prognosis than with classic dermatomyositis&#46;<a class="elsevierStyleCrossRefs" href="#bib0070"><span class="elsevierStyleSup">4&#44;6&#44;10</span></a> The combination of high doses of intravenous corticosteroids and immunosuppressants seems to be a good alternative&#59; immunoglobulins can be added when there is no response&#44;<a class="elsevierStyleCrossRefs" href="#bib0065"><span class="elsevierStyleSup">3&#44;5&#44;8</span></a> and rituximab can be administered in refractory cases&#46;<a class="elsevierStyleCrossRefs" href="#bib0055"><span class="elsevierStyleSup">1&#44;2</span></a></p><p id="par0030" class="elsevierStylePara elsevierViewall">Evans syndrome &#40;anemia and&#47;or autoimmune thrombocytopenia&#41; rarely occurs with dermatomyositis&#46; The first case was reported in 1990 in a woman with generalized edematous dermatomyositis&#46;<a class="elsevierStyleCrossRef" href="#bib0065"><span class="elsevierStyleSup">3</span></a> Although we were unable to confirm an autoimmune etiology in the case we report&#44; the clinical and laboratory data were consistent with this diagnosis&#46;</p><p id="par0035" class="elsevierStylePara elsevierViewall">We report a new case of severe edematous dermatomyositis that proved refractory to several systemic treatments but responded well to rituximab&#46; The condition probably occurred with Evans syndrome&#46;</p><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0005">Conflicts of Interest</span><p id="par0040" class="elsevierStylePara elsevierViewall">The authors declare that they have no conflicts of interest&#46;</p></span></span>"
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Case and Research Letter
Edematous Dermatomyositis with Probable Evans Syndrome
Dermatomiositis edematosa asociada a probable síndrome de Evans
M.Á. Flores-Terrya,
Autor para correspondencia
miguelterry85@hotmail.com

Corresponding author.
, M. García-Arpaa, J. Anino-Fernándezb, M.D. Mínguez-Sánchezb
a Servicio de Dermatología, Hospital General Universitario de Ciudad Real, Ciudad Real, Spain
b Servicio de Reumatología, Hospital General Universitario de Ciudad Real, Ciudad Real, Spain
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The results of antibody testing &#40;antinuclear antibodies&#44; anti-RNP&#44; anti-Jo1&#44; and anti-p155&#41; were negative&#46; Analysis of a skin biopsy specimen revealed vacuolar changes at the dermal-epidermal junction&#44; solitary necrotic keratinocytes&#44; and mucin deposits in the dermis&#46; The electromyogram revealed signs of inflammatory myopathy&#44; and occult underlying neoplasm was ruled out by tumor markers and positron emission tomography and computed tomography imaging&#46; These findings confirmed the diagnosis of dermatomyositis&#44; and treatment was started with intravenous methylprednisolone &#40;1<span class="elsevierStyleHsp" style=""></span>mg&#47;kg&#47;d&#41;&#59; after 5 days&#44; 4 doses of immunoglobulin &#40;1&#46;5<span class="elsevierStyleHsp" style=""></span>g&#47;kg&#47;dose&#41; were added&#44; although there was little improvement&#46; During the following months&#44; the patient&#39;s condition progressed with intense edema affecting the face&#44; neck&#44; and upper extremities &#40;visible on the magnetic resonance image&#41; and myositis &#40;<a class="elsevierStyleCrossRefs" href="#fig0005">Figs&#46; 1&#8211;3</a>&#41;&#46; Therefore&#44; methotrexate was added to the treatment regimen at 2 months&#44; hydroxychloroquine at 4 months&#44; and&#44; given the lack of improvement&#44; rituximab &#40;1<span class="elsevierStyleHsp" style=""></span>g&#41; at 6 months in 2 doses separated by 2 weeks&#46; The response was good&#44; mainly in the skin&#46; During follow-up&#44; occasional thrombocytopenia and anemia &#40;hemoglobin&#44; 10&#46;8<span class="elsevierStyleHsp" style=""></span>g&#47;dL&#59; platelets&#44; 58&#160;000&#47;&#956;L&#41; were recorded&#44; as were increased values for indirect bilirubin &#40;1<span class="elsevierStyleHsp" style=""></span>mg&#47;dL &#91;&#62;<span class="elsevierStyleHsp" style=""></span>0&#46;7&#93;&#41; and lactate dehydrogenase &#40;641<span class="elsevierStyleHsp" style=""></span>IU&#47;L &#91;&#62;<span class="elsevierStyleHsp" style=""></span>385&#93;&#41;&#46; These findings were compatible with Evans syndrome with dermatomyositis occurring alongside worsening muscle enzyme values&#46; However&#44; as the patient was receiving treatment with corticosteroids&#44; it was impossible to perform the Coombs test to confirm this associated autoimmune etiology&#46; Similarly&#44; it was not possible to rule out other etiologies&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><elsevierMultimedia ident="fig0010"></elsevierMultimedia><elsevierMultimedia ident="fig0015"></elsevierMultimedia><p id="par0015" class="elsevierStylePara elsevierViewall">Dermatomyositis is an autoimmune disease that mainly affects the skin and muscle&#46; It has traditionally taken the form of mild periorbital edema accompanied by heliotrope rash&#46; However&#44; edematous dermatomyositis involves more extensive swelling&#46; It is also a rare clinical variant of the condition&#44; with only 23 cases reported in the literature&#46;<a class="elsevierStyleCrossRef" href="#bib0055"><span class="elsevierStyleSup">1</span></a> The etiology and pathogenesis remain unclear&#44; although some authors have pointed to intense inflammatory activity with activation and deposition of complement&#44; leading to vascular disease with muscle microinfarcts that in turn increase vascular permeability&#46;<a class="elsevierStyleCrossRefs" href="#bib0055"><span class="elsevierStyleSup">1&#8211;5</span></a> This manifests clinically as edema affecting muscle and&#47;or subcutaneous tissue&#44; with or without pitting&#46; Age at presentation is variable&#44;<a class="elsevierStyleCrossRefs" href="#bib0055"><span class="elsevierStyleSup">1&#44;2&#44;6</span></a> with most adult cases occurring in women&#46;<a class="elsevierStyleCrossRef" href="#bib0055"><span class="elsevierStyleSup">1</span></a> Edema mainly affects the upper extremities&#44; although it may be generalized<a class="elsevierStyleCrossRefs" href="#bib0070"><span class="elsevierStyleSup">4&#44;6&#44;7</span></a>&#59; cases of local edema have also been reported&#46;<a class="elsevierStyleCrossRefs" href="#bib0060"><span class="elsevierStyleSup">2&#44;8&#44;9</span></a> Edematous dermatomyositis usually progresses more rapidly than classic dermatomyositis&#46;<a class="elsevierStyleCrossRef" href="#bib0075"><span class="elsevierStyleSup">5</span></a> Edema usually develops after skin involvement&#44; although it may also be the initial presentation<a class="elsevierStyleCrossRef" href="#bib0080"><span class="elsevierStyleSup">6</span></a>&#59; there have even been reports of edematous dermatomyositis with no other cutaneous findings&#46;<a class="elsevierStyleCrossRef" href="#bib0075"><span class="elsevierStyleSup">5</span></a> Muscle involvement and dysphagia are frequently associated with edematous dermatomyositis&#44;<a class="elsevierStyleCrossRefs" href="#bib0055"><span class="elsevierStyleSup">1&#44;4</span></a> as observed in the case we report&#46;</p><p id="par0020" class="elsevierStylePara elsevierViewall">It remains unclear whether this clinical presentation of dermatomyositis implies a greater risk of neoplasm<a class="elsevierStyleCrossRef" href="#bib0075"><span class="elsevierStyleSup">5</span></a>&#59; according to a recently published literature review&#44; the risk of neoplasm was recorded in fewer than 30&#37; of cases &#40;6 of 23 cases reviewed&#41;&#46;<a class="elsevierStyleCrossRef" href="#bib0055"><span class="elsevierStyleSup">1</span></a></p><p id="par0025" class="elsevierStylePara elsevierViewall">Before a diagnosis of edematous dermatomyositis can be confirmed&#44; it is important to rule out other&#44; secondary causes of edema&#44;<a class="elsevierStyleCrossRef" href="#bib0055"><span class="elsevierStyleSup">1</span></a> such as kidney&#44; heart&#44; and thyroid disease&#44; as well as hypoproteinemia&#46; Treatment of edematous dermatomyositis should be intensive and early&#44; given the potentially severe nature of the symptoms<a class="elsevierStyleCrossRefs" href="#bib0055"><span class="elsevierStyleSup">1&#44;4&#44;5&#44;9&#44;10</span></a> and the probable poorer prognosis than with classic dermatomyositis&#46;<a class="elsevierStyleCrossRefs" href="#bib0070"><span class="elsevierStyleSup">4&#44;6&#44;10</span></a> The combination of high doses of intravenous corticosteroids and immunosuppressants seems to be a good alternative&#59; immunoglobulins can be added when there is no response&#44;<a class="elsevierStyleCrossRefs" href="#bib0065"><span class="elsevierStyleSup">3&#44;5&#44;8</span></a> and rituximab can be administered in refractory cases&#46;<a class="elsevierStyleCrossRefs" href="#bib0055"><span class="elsevierStyleSup">1&#44;2</span></a></p><p id="par0030" class="elsevierStylePara elsevierViewall">Evans syndrome &#40;anemia and&#47;or autoimmune thrombocytopenia&#41; rarely occurs with dermatomyositis&#46; The first case was reported in 1990 in a woman with generalized edematous dermatomyositis&#46;<a class="elsevierStyleCrossRef" href="#bib0065"><span class="elsevierStyleSup">3</span></a> Although we were unable to confirm an autoimmune etiology in the case we report&#44; the clinical and laboratory data were consistent with this diagnosis&#46;</p><p id="par0035" class="elsevierStylePara elsevierViewall">We report a new case of severe edematous dermatomyositis that proved refractory to several systemic treatments but responded well to rituximab&#46; The condition probably occurred with Evans syndrome&#46;</p><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0005">Conflicts of Interest</span><p id="par0040" class="elsevierStylePara elsevierViewall">The authors declare that they have no conflicts of interest&#46;</p></span></span>"
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        "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Please cite this article as&#58; Flores-Terry M&#193;&#44; Garc&#237;a-Arpa M&#44; Anino-Fern&#225;ndez J&#44; M&#237;nguez-S&#225;nchez MD&#46; Dermatomiositis edematosa asociada a probable s&#237;ndrome de Evans&#46; Actas Dermosifiliogr&#46; 2017&#59;108&#58;673&#8211;675&#46;</p>"
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          "en" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Erythematous macular lesions on the metacarpophalangeal joints and the dorsum of the fingers&#44; with edema &#40;the arrow indicates the pressure exerted by the patient&#39;s ring&#41;&#46;</p>"
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Actas Dermo-Sifiliográficas
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¿Es usted profesional sanitario apto para prescribir o dispensar medicamentos?

Are you a health professional able to prescribe or dispense drugs?