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where 38&#37; of overweight persons &#40;with a body mass index &#91;BMI&#93; between 25 and 30&#41; have NAFLD&#46; The prevalence rates in obese &#40;BMI&#44; 30&#8211;40&#41; and severely obese &#40;BMI&#44; 40&#8211;45&#41; persons are 46&#37; and 65&#37;&#44; respectively&#46; Finally&#44; some 90&#37; of morbidly obese patients &#40;BMI<span class="elsevierStyleHsp" style=""></span>&#62;<span class="elsevierStyleHsp" style=""></span>45&#41; have this condition&#44; and 5&#37; of them have cirrhosis&#46; Among diabetics&#44; the prevalence is 69&#37;&#44; and among patients with elevated triglyceride levels&#44; 50&#37;&#46;<a class="elsevierStyleCrossRef" href="#bib0335"><span class="elsevierStyleSup">7</span></a> A sign of the seriousness of this situation is that nonalcoholic steatohepatitis is currently the second most common cause of liver transplantation in the United States&#44; and it is expected to become the first cause in the coming years&#46;<a class="elsevierStyleCrossRef" href="#bib0340"><span class="elsevierStyleSup">8</span></a></p><p id="par0020" class="elsevierStylePara elsevierViewall">In spite of these statistics&#44; NAFLD is clearly underdiagnosed because there are no signs or symptoms that arouse suspicion except when the disease becomes advanced and also because serum biochemical markers show only slight&#44; nonspecific changes&#59; results may even stay within the normal limits in 15&#37; to 39&#37; of patients&#46;<a class="elsevierStyleCrossRefs" href="#bib0345"><span class="elsevierStyleSup">9&#44;10</span></a></p><p id="par0025" class="elsevierStylePara elsevierViewall">A diagnosis of NAFLD requires evidence of steatosis by liver biopsy or imaging and the exclusion of alcohol consumption or other general causes of liver disease or conditions that lead to steatosis&#46;<a class="elsevierStyleCrossRef" href="#bib0305"><span class="elsevierStyleSup">1</span></a> The first criterion&#8212;evidence of steatosis&#8212;is critical&#46; The list of causes of liver disease are well established<a class="elsevierStyleCrossRef" href="#bib0355"><span class="elsevierStyleSup">11</span></a> while the alternative causes of steatosis are very rare and&#44; in principle&#44; relatively easy to identify&#46; A liver biopsy is the gold standard&#44; but it is invasive&#44; has associated risk of complications and death&#44; and is costly&#46;<a class="elsevierStyleCrossRef" href="#bib0360"><span class="elsevierStyleSup">12</span></a> Furthermore&#44; it is not reasonable or even feasible to biopsy 20&#37; of the population&#46; Interest in finding a noninvasive approach to diagnosis is therefore growing&#46; A fatty liver is usually detected through imaging &#40;ultrasound&#44; computed tomography scans&#44; or nuclear magnetic resonance&#41;&#59; the sensitivity and specificity of images are 60&#37; and 94&#37;&#44; respectively&#46;<a class="elsevierStyleCrossRefs" href="#bib0365"><span class="elsevierStyleSup">13&#44;14</span></a> Ultrasound is usually chosen because it is innocuous and widely available&#46;<a class="elsevierStyleCrossRef" href="#bib0305"><span class="elsevierStyleSup">1</span></a> However&#44; neither liver enzymes nor images can distinguish between steatosis and steatohepatitis&#46; Nor can they establish or rule out the presence of fibrosis&#46; Various scoring systems using the results of serum tests have therefore been developed&#46; The most widely accepted is the NAFLD fibrosis score&#44;<a class="elsevierStyleCrossRef" href="#bib0375"><span class="elsevierStyleSup">15</span></a> which is calculated according to a formula &#40;<a href="http://nafldscore.com/">http&#58;&#47;&#47;nafldscore&#46;com</a>&#41; based on easy-to-obtain measurements&#58; BMI&#59; age&#59; platelet count&#59; and serum albumin&#44; aspartate transaminase &#40;AST&#41;&#44; and alanine transaminase &#40;ALT&#41; &#40;<a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a>&#41;&#46; Moreover&#44; this score is highly sensitive &#40;67&#37;&#41; and specific &#40;60&#37;&#41; for excluding &#40;67&#37;&#41; or detecting &#40;97&#37;&#41; the presence of advanced fibrosis using an area under the receiver operating characteristic curve of 0&#46;85 as the cutoff&#46; The severity of liver damage can also potentially be assessed by measuring liver stiffness indirectly with elastography&#46; The usefulness of this approach would mainly be to identify patients at low risk of advanced fibrosis or cirrhosis given the test&#39;s lack of precision when disease is advanced&#46;<a class="elsevierStyleCrossRef" href="#bib0380"><span class="elsevierStyleSup">16</span></a></p><elsevierMultimedia ident="tbl0005"></elsevierMultimedia><p id="par0030" class="elsevierStylePara elsevierViewall">The European Association for the Study of the Liver&#44; the European Association for the Study of Diabetes&#44; and the European Association for the Study of Obesity have recently published new joint guidelines for managing NAFLD&#46;<a class="elsevierStyleCrossRef" href="#bib0385"><span class="elsevierStyleSup">17</span></a> They recommend that all patients with insulin resistance or risk factors for metabolic syndrome be screened for NAFLD by ultrasound and liver biochemistry&#46; Any increase in AST&#44; ALT&#44; and&#47;or &#947;-glutamyltransferase are relevant&#44; regardless of magnitude&#46; The screening algorithm is shown in <a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>&#46;<a class="elsevierStyleCrossRef" href="#bib0385"><span class="elsevierStyleSup">17</span></a></p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0030">Therapeutic Management of NAFLD</span><p id="par0035" class="elsevierStylePara elsevierViewall">At this time there is no specific treatment for NAFLD available&#46; Weight loss of at least 7&#37; to 10&#37; and exercise are associated with histologic improvement&#44;<a class="elsevierStyleCrossRef" href="#bib0390"><span class="elsevierStyleSup">18</span></a> but they are difficult to achieve and particularly difficult to maintain long-term&#46; Alcohol&#44; saturated fats&#44; and fructose-sweetened beverages should be avoided&#46;<a class="elsevierStyleCrossRef" href="#bib0395"><span class="elsevierStyleSup">19</span></a> Coffee consumption&#44; on the other hand&#44; can be recommended&#46;<a class="elsevierStyleCrossRef" href="#bib0400"><span class="elsevierStyleSup">20</span></a> Several drugs &#40;metformin&#44; pioglitazone&#44; eicosapentenoic acid&#44; statins&#44; and vitamin E&#41; have been tried&#44; but there is a lack of sufficient evidence on which to base a strong recommendation&#46;<a class="elsevierStyleCrossRefs" href="#bib0305"><span class="elsevierStyleSup">1&#44;6&#44;21&#8211;24</span></a></p></span></span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0035">NAFLD and Psoriasis</span><p id="par0040" class="elsevierStylePara elsevierViewall">The first observational studies showing an association between NAFLD and psoriasis began to appear during the last 10 years&#44;<a class="elsevierStyleCrossRefs" href="#bib0425"><span class="elsevierStyleSup">25&#44;26</span></a> and the association has since been confirmed&#46;<a class="elsevierStyleCrossRefs" href="#bib0435"><span class="elsevierStyleSup">27&#44;28</span></a> Gisondi<span class="elsevierStyleHsp" style=""></span>et<span class="elsevierStyleHsp" style=""></span>al&#46;<a class="elsevierStyleCrossRef" href="#bib0425"><span class="elsevierStyleSup">25</span></a> saw a higher rate of ultrasound-diagnosed NAFLD &#40;47&#37;&#41; in a series of 130 consecutive patients with psoriasis than in 260 healthy controls &#40;28&#37;&#41; matched for age&#44; sex&#44; and BMI&#46; The psoriasis patients were also more likely to have metabolic syndrome and higher C-reactive protein levels&#59; those who also had NAFLD had higher interleukin &#40;IL&#41; 6 and lower adiponectin levels than those without the disease&#46; Abedini<span class="elsevierStyleHsp" style=""></span>et<span class="elsevierStyleHsp" style=""></span>al&#46;<a class="elsevierStyleCrossRef" href="#bib0440"><span class="elsevierStyleSup">28</span></a> reported finding NAFLD in 65&#46;6&#37; of patients with psoriasis &#40;vs 35&#37; of healthy controls&#41;&#44; and van<span class="elsevierStyleHsp" style=""></span>der<span class="elsevierStyleHsp" style=""></span>Voort<span class="elsevierStyleHsp" style=""></span>et<span class="elsevierStyleHsp" style=""></span>al&#46;<a class="elsevierStyleCrossRef" href="#bib0435"><span class="elsevierStyleSup">27</span></a> found that 46&#46;2&#37; of psoriatic patients and 33&#46;3&#37; of controls had NAFLD in a population-based series of 2292 persons over the age of 55 years in Rotterdam&#46; These findings may be attributable to the association between psoriasis and metabolic syndrome&#44; given that the conditions defining the latter are those that lead to NAFLD&#46;<a class="elsevierStyleCrossRef" href="#bib0445"><span class="elsevierStyleSup">29</span></a> Miele<span class="elsevierStyleHsp" style=""></span>et<span class="elsevierStyleHsp" style=""></span>al&#46;<a class="elsevierStyleCrossRef" href="#bib0430"><span class="elsevierStyleSup">26</span></a> studied a cohort of psoriasis patients with and without NAFLD&#44; finding that NAFLD was also associated with psoriatic arthritis&#46; Roberts<span class="elsevierStyleHsp" style=""></span>et<span class="elsevierStyleHsp" style=""></span>al&#46;<a class="elsevierStyleCrossRef" href="#bib0450"><span class="elsevierStyleSup">30</span></a> reported finding a relationship between greater severity of psoriasis and NAFLD&#46; Specifically&#44; they saw steatohepatitis in 22&#37; of the patients with both psoriasis and NAFLD who underwent liver biopsy&#46; The NAFLD patients with steatohepatitis were also more likely to be obese and have higher insulin and transaminase levels&#59; they also found marked differences in risk for NAFLD according to ethnic origin&#46; Similarly&#44; van<span class="elsevierStyleHsp" style=""></span>der<span class="elsevierStyleHsp" style=""></span>Voort<span class="elsevierStyleHsp" style=""></span>et<span class="elsevierStyleHsp" style=""></span>al&#46;<a class="elsevierStyleCrossRef" href="#bib0435"><span class="elsevierStyleSup">27</span></a> found that patients of Latin American origin carried greater risk &#40;83&#37;&#41;&#44; followed by Caucasians &#40;39&#37;&#41;&#44; and finally African Americans &#40;33&#37;&#41;&#46;</p><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0040">Clinical Suspicion and Screening for NAFLD in Dermatology</span><p id="par0045" class="elsevierStylePara elsevierViewall">A high index of suspicion concerning NAFLD is needed in dermatology because most cases encountered will be asymptomatic&#46; The dermatologist should above all be aware of the high prevalence in patients with psoriasis&#46; It is also important to note signs of the components of metabolic syndrome&#58; diabetes mellitus&#44; obesity&#44; dyslipidemia&#44; and hypertension&#46; Abnormal liver enzymes may be difficult to discern because elevations are usually slight&#44; at less than 2- to 3-fold the normal values and with an ALT&#47;AST ratio greater than 1&#59; alkaline phosphatase and &#947;-glutamyltransferase are occasionally elevated&#46;<a class="elsevierStyleCrossRef" href="#bib0455"><span class="elsevierStyleSup">31</span></a> Liver enzymes can be normal in 15&#37; to 30&#37; or more of patients with NAFLD&#44;<a class="elsevierStyleCrossRef" href="#bib0350"><span class="elsevierStyleSup">10</span></a> even though 35&#37; of such patients have advanced fibrosis or cirrhosis&#46; Given this situation&#44; in the presence of the most prevalent indicator of risk for NAFLD&#8212;namely components of metabolic syndrome&#8212;ultrasound imaging to rule out liver disease is indicated even when biochemistry is normal&#46;<a class="elsevierStyleCrossRef" href="#bib0385"><span class="elsevierStyleSup">17</span></a> At this time&#44; however&#44; the clinical algorithm recommended by most medical associations specializing in NAFLD &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>&#41;&#44; does not recognize the need for imaging to evaluate patients with psoriasis in the absence of liver enzyme abnormalities&#46;</p><p id="par0050" class="elsevierStylePara elsevierViewall">Once NAFLD has been confirmed&#44; the dermatologist must cooperate in prescribing the necessary dietary measures and adjusting drug dosages if transaminase levels are elevated&#46;</p><p id="par0055" class="elsevierStylePara elsevierViewall">The absence of liver damage according to the initial assessment does not exclude its development over the coming years&#46; Therefore&#44; patients will have to be reassessed if analyses reveal signs of damage or if metabolic syndrome develops&#46;<a class="elsevierStyleCrossRef" href="#bib0385"><span class="elsevierStyleSup">17</span></a></p></span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0045">Pathogenesis of NAFLD in Psoriasis</span><p id="par0060" class="elsevierStylePara elsevierViewall">This review does not attempt to delve deeply into the pathogenesis of NAFLD&#44; but it is useful to be aware of the two-hit hypothesis&#46;<a class="elsevierStyleCrossRef" href="#bib0460"><span class="elsevierStyleSup">32</span></a> In this theory&#44; the first phase would be marked by the abnormal accumulation of triglycerides in liver cells&#44; a development in which insulin resistance plays a large role&#46; In the second phase&#44; the steatotic liver appears to become susceptible to injury induced by several players and events involving various adipokines and oxidative stress in the endoplasmic reticulum&#44; as well as mitochondrial dysfunction and liver apoptosis&#46; These events favor the transition from simple steatosis to steatohepatitis&#46; Besides the involvement of insulin resistance in both these phases of progression toward NAFLD&#8212;as well as in the induction and activation of profibrotic cytokines&#8212;other chronic inflammatory processes that might be present&#44; such as psoriasis&#44; can contribute proinflammatory cytokines&#46;<a class="elsevierStyleCrossRef" href="#bib0465"><span class="elsevierStyleSup">33</span></a> Thus&#44; the pathogenic relationship between NAFLD and psoriasis is complex and probably multifactorial&#44; although it is presumably related to a state of chronic underlying inflammation&#46;</p><p id="par0065" class="elsevierStylePara elsevierViewall">NAFLD and psoriasis are probably linked partly because some of the conditions that often accompany psoriasis are also the ones that cause NAFLD&#46; Among them&#44; obesity stands out&#46; The epidemiologic association between obesity and psoriasis is clear&#44; particularly in severe psoriasis&#44; and the influences probably operate in both directions&#44; such that obesity favors psoriasis and vice versa&#46;<a class="elsevierStyleCrossRef" href="#bib0470"><span class="elsevierStyleSup">34</span></a> The prevalence of NAFLD is also clearly higher in obese patients&#44; especially those with excess abdominal fat&#44; which is more metabolically active than subcutaneous fat&#46;<a class="elsevierStyleCrossRef" href="#bib0475"><span class="elsevierStyleSup">35</span></a> Obesity is associated with risk for developing insulin resistance&#44; the main factor in the development of NAFLD&#46;<a class="elsevierStyleCrossRef" href="#bib0480"><span class="elsevierStyleSup">36</span></a> Excessive fat deposition leads to an imbalance between pro- and anti-inflammatory cytokines&#44; favoring the progression of liver disease&#46; When adipose tissue secretes an abundance of adipokines&#8212;tumor necrosis factor &#40;TNF&#41;&#44; IL-6&#44; leptin&#44; visfatin&#44; or resistin&#8212;a proinflammatory state may develop in psoriatic skin as the result of the proliferation of keratinocytes&#44; angiogenesis&#44; the response of type 1<span class="elsevierStyleHsp" style=""></span>T cells&#44; or the expression of adhesion molecules&#46; This state may also be expressed in NAFLD&#44; contributing to insulin resistance or liver fibrosis&#46; In addition&#44; there is also a decrease in the concentration of adipokines that protect against inflammation&#8212;such as adiponectin&#44; a promotor of skin anti-inflammatory cytokines that enhances insulin sensitivity&#46;<a class="elsevierStyleCrossRef" href="#bib0485"><span class="elsevierStyleSup">37</span></a></p><p id="par0070" class="elsevierStylePara elsevierViewall">The involvement of IL-17 in both psoriasis and NAFLD is interesting&#46; T cells in adipose tissue synthesize IL-17&#44; which is able to regulate adipogenesis and glucose metabolism&#46; Type 17<span class="elsevierStyleHsp" style=""></span>T helper cells and IL-17 could facilitate the progression from simple steatosis to steatohepatitis&#46;<a class="elsevierStyleCrossRef" href="#bib0490"><span class="elsevierStyleSup">38</span></a></p></span><span id="sec0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0050">Implications for the Management of Conventional Systemic Treatments</span><p id="par0075" class="elsevierStylePara elsevierViewall">The high prevalence of NAFLD in psoriasis leads to therapeutic concerns because this chronic skin disease must be treated over decades&#46;</p><p id="par0080" class="elsevierStylePara elsevierViewall">The incidence of MTX-induced liver damage is known to be higher in psoriasis<a class="elsevierStyleCrossRef" href="#bib0495"><span class="elsevierStyleSup">39</span></a> than in other chronic inflammatory diseases&#46; A recent retrospective study saw&#44; for example&#44; that 58&#37; of 710 patients on MTX for psoriasis had elevated transaminase levels&#46;<a class="elsevierStyleCrossRef" href="#bib0500"><span class="elsevierStyleSup">40</span></a> In the light of our current understanding&#44; this finding may be relevant to the known association between NAFLD and psoriasis&#46; Given the high rates of both NAFLD and steatohepatitis in this setting&#44; we should rule out significant steatosis before starting MTX&#44; at least in patients with signs of metabolic syndrome&#46; In addition to ultrasound screening&#44; two new tools&#44; the FibroTest and the FibroScan &#40;liver elastography&#41; may be useful for assessing liver fibrosis&#46;<a class="elsevierStyleCrossRef" href="#bib0505"><span class="elsevierStyleSup">41</span></a></p><p id="par0085" class="elsevierStylePara elsevierViewall">MTX toxicity presents with histologic findings and may therefore reflect pathogenic mechanisms that are different from those associated with NAFLD&#46; However&#44; the shared risk factors that aggravate both MTX toxicity and NAFLD&#8212;such as obesity&#44; diabetes&#44; or hyperlipidemia&#8212;are observed often in patients with severe psoriasis&#46;<a class="elsevierStyleCrossRef" href="#bib0510"><span class="elsevierStyleSup">42</span></a></p><p id="par0090" class="elsevierStylePara elsevierViewall">Liver toxicity is also among the potential adverse effects of ciclosporin&#46; The effect may be direct or it may be a byproduct of a deteriorating lipid profile&#46;<a class="elsevierStyleCrossRef" href="#bib0515"><span class="elsevierStyleSup">43</span></a> Acitretin can also raise triglyceride levels and has been associated with transaminase elevations in 1 out of 4 patients&#44; although tissue damage following intermittent use of the drug has not been reported&#46;<a class="elsevierStyleCrossRef" href="#bib0520"><span class="elsevierStyleSup">44</span></a></p></span></span><span id="sec0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0055">Biologic Agents in Patients With Psoriasis and NAFLD</span><p id="par0095" class="elsevierStylePara elsevierViewall">TNF plays a central role in the inflammatory process in NAFLD&#44; as in other chronic inflammatory diseases&#46;<a class="elsevierStyleCrossRef" href="#bib0525"><span class="elsevierStyleSup">45</span></a> In fact&#44; TNF has been studied for its potential use as a diagnostic and prognostic tool in NAFLD&#46;<a class="elsevierStyleCrossRef" href="#bib0530"><span class="elsevierStyleSup">46</span></a> Given the pathogenic role of this cytokine&#44; anti-TNF agents such as infliximab and adalimumab have also been tried in this setting<a class="elsevierStyleCrossRefs" href="#bib0535"><span class="elsevierStyleSup">47&#44;48</span></a> because of improvements observed in liver and metabolic biomarkers after biologic therapy for other inflammatory diseases&#46;<a class="elsevierStyleCrossRefs" href="#bib0545"><span class="elsevierStyleSup">49&#44;50</span></a></p><p id="par0100" class="elsevierStylePara elsevierViewall">Biologics have a better safety profile than the conventional treatments for NAFLD mentioned earlier&#46; For example&#44; when adalimumab was used for an average of 5 years in 32 patients with liver disease and psoriasis&#44; no cases of liver disease progression or development of liver toxicity were observed&#46;<a class="elsevierStyleCrossRef" href="#bib0555"><span class="elsevierStyleSup">51</span></a></p><p id="par0105" class="elsevierStylePara elsevierViewall">Biologic therapy could exercise regulatory effects on some adipocytokines&#46; Shibata<span class="elsevierStyleHsp" style=""></span>et<span class="elsevierStyleHsp" style=""></span>al&#46;<a class="elsevierStyleCrossRef" href="#bib0560"><span class="elsevierStyleSup">52</span></a> reported an increase in adiponectin and IL-6 levels during treatment with infliximab&#44; and adalimumab and etanercept may inhibit proinflammatory adipocytokines&#46;<a class="elsevierStyleCrossRef" href="#bib0565"><span class="elsevierStyleSup">53</span></a></p><p id="par0110" class="elsevierStylePara elsevierViewall">Studies of the impact of anti-TNF agents on the lipid profile&#44; a risk factor for NAFLD&#44; have yielded inconsistent results&#46; While some authors have not been able to demonstrate a significant effect&#44; others have reported elevated triglycerides and lower high-density lipoprotein &#40;HDL&#41; cholesterol levels in patients with infliximab-treated psoriatic arthritis&#46;<a class="elsevierStyleCrossRef" href="#bib0570"><span class="elsevierStyleSup">54</span></a> Etanercept therapy&#44; on the other hand&#44; has favorably modulated the antioxident and anti-inflammatory properties of HDL cholesterol as well as modulated adipolipoprotein A1 and B levels&#44; reducing lipid peroxidation&#46;<a class="elsevierStyleCrossRef" href="#bib0575"><span class="elsevierStyleSup">55</span></a></p><p id="par0115" class="elsevierStylePara elsevierViewall">Marra et al&#46;<a class="elsevierStyleCrossRef" href="#bib0580"><span class="elsevierStyleSup">56</span></a> showed improved insulin sensitivity in patients treated with etanercept for psoriasis&#44; an effect that could potentially have a favorable influence on the course of NAFLD&#46;</p><p id="par0120" class="elsevierStylePara elsevierViewall">It must be borne in mind that anti-TNF agents can occasionally induce autoimmune or drug-related hepatitis&#46;<a class="elsevierStyleCrossRef" href="#bib0585"><span class="elsevierStyleSup">57</span></a> The risk is very low&#44; however&#46; Only 20 cases of autoimmune hepatitis have ever been reported&#59; most were mild cases associated with infliximab and responded quickly to steroid treatment&#46;<a class="elsevierStyleCrossRef" href="#bib0505"><span class="elsevierStyleSup">41</span></a> Anti-TNF agents have also been linked to weight gain in psoriasis patients&#44; although the gains have generally been modest&#46; However&#44; long-term use has led to considerable gain in some patients&#44; and this adverse effect potentially aggravates the obesity associated with severe psoriasis and NAFLD&#46;<a class="elsevierStyleCrossRef" href="#bib0590"><span class="elsevierStyleSup">58</span></a></p><p id="par0125" class="elsevierStylePara elsevierViewall">High transaminase levels were detected in 6 patients in a series of 44 treated with ustekinumab for an average of 46&#46;7 months&#46;<a class="elsevierStyleCrossRef" href="#bib0595"><span class="elsevierStyleSup">59</span></a> Five of the 6 patients developed hepatotoxicity related to other drugs&#44; 3 developed fatty liver&#44; and 3 were receiving other hepatotoxic drugs while taking ustekinumab&#46; The authors concluded that ustekinumab-related toxicity was mild and uncommon&#46; Hepatotoxicity is not described as a side effect detected in clinical trials of secukinumab<a class="elsevierStyleCrossRef" href="#bib0600"><span class="elsevierStyleSup">60</span></a> &#40;<a class="elsevierStyleCrossRef" href="#tbl0010">Table 2</a>&#41;&#46;</p><elsevierMultimedia ident="tbl0010"></elsevierMultimedia></span><span id="sec0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0060">Conclusions</span><p id="par0130" class="elsevierStylePara elsevierViewall">NAFLD is the most frequent liver disorder in the West &#40;<a class="elsevierStyleCrossRef" href="#tbl0015">Table 3</a>&#41;&#46; Patients with psoriasis have a higher prevalence of NAFLD&#44; a higher rate of severe disease&#44; and a worse prognosis&#46; Dermatologists should routinely evaluate psoriasis patients for NAFLD&#46; The pathogenic links between psoriasis and NAFLD are chronic inflammation and peripheral insulin resistance&#44; which is a common finding in diseases associated with psoriasis&#46; The dermatologist should be aware not only of the high prevalence of NAFLD in psoriasis but also of the possibility of steatohepatitis&#44; especially when psoriasis is severe or when there are signs of metabolic syndrome&#46; Psoriasis patients with insulin resistance or risk factors for metabolic syndrome should be specifically evaluated for fatty liver by abdominal ultrasound and liver biochemistry&#46; Concurrent psoriasis and NAFLD&#44; and the likely synergy between them&#44; affect the general recommendations we can make and the treatment strategies we can adopt&#46; Some drugs carry risk of hepatotoxicity&#46; On the other hand&#44; there is a possibility that achieving good control of inflammation and pathogenic factors associated with NAFLD will improve the prognosis&#46;<elsevierMultimedia ident="tb0005"></elsevierMultimedia></p><elsevierMultimedia ident="tbl0015"></elsevierMultimedia></span><span id="sec0050" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0070">Ethical Disclosures</span><span id="sec0055" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0075">Protection of human and animal subjects</span><p id="par0170" class="elsevierStylePara elsevierViewall">The authors declare that no experiments were performed on humans or animals for this investigation&#46;</p></span><span id="sec0060" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0080">Data confidentiality</span><p id="par0175" class="elsevierStylePara elsevierViewall">The authors declare that no private patient data are disclosed in this article&#46;</p></span><span id="sec0065" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0085">Right to privacy and informed consent</span><p id="par0180" class="elsevierStylePara elsevierViewall">The authors declare that no private patient data are disclosed in this article&#46;</p></span></span><span id="sec0070" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0090">Conflicts of Interest</span><p id="par0185" class="elsevierStylePara elsevierViewall">Abbvie sponsored the meetings of the working group&#44; but no employees of the laboratory participated in the research&#44; interpretation&#44; discussion&#44; or drafting of the text&#46;</p><p id="par0190" class="elsevierStylePara elsevierViewall">J&#46; M&#46; Carrascosa has served as a consultant&#44; given invited talks&#44; and&#47;or participated in clinical trials sponsored by the following laboratories&#58; Abbvie&#44; Janssen&#44; Lilly&#44; Pfizer&#44; Novartis&#44; Pfizer&#44; and Celgene&#46;</p></span></span>"
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          "titulo" => "Nonalcoholic Fatty Liver Disease&#58; The Concept"
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              "titulo" => "Therapeutic Management of NAFLD"
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              "identificador" => "sec0065"
              "titulo" => "Right to privacy and informed consent"
            ]
          ]
        ]
        9 => array:2 [
          "identificador" => "sec0070"
          "titulo" => "Conflicts of Interest"
        ]
        10 => array:1 [
          "titulo" => "References"
        ]
      ]
    ]
    "pdfFichero" => "main.pdf"
    "tienePdf" => true
    "fechaRecibido" => "2016-07-21"
    "fechaAceptado" => "2016-12-31"
    "PalabrasClave" => array:2 [
      "en" => array:1 [
        0 => array:4 [
          "clase" => "keyword"
          "titulo" => "Keywords"
          "identificador" => "xpalclavsec852686"
          "palabras" => array:6 [
            0 => "Psoriasis"
            1 => "Nonalcoholic fatty liver disease"
            2 => "Steatosis"
            3 => "Treatment"
            4 => "Biologic agents"
            5 => "Methotrexate"
          ]
        ]
      ]
      "es" => array:1 [
        0 => array:4 [
          "clase" => "keyword"
          "titulo" => "Palabras clave"
          "identificador" => "xpalclavsec852685"
          "palabras" => array:6 [
            0 => "Psoriasis"
            1 => "H&#237;gado graso no alcoh&#243;lico"
            2 => "Esteatosis"
            3 => "Tratamiento"
            4 => "Biol&#243;gicos"
            5 => "Metotrexato"
          ]
        ]
      ]
    ]
    "tieneResumen" => true
    "resumen" => array:2 [
      "en" => array:2 [
        "titulo" => "Abstract"
        "resumen" => "<span id="abst0005" class="elsevierStyleSection elsevierViewall"><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Nonalcoholic fatty liver disease &#40;NAFLD&#41; is the most prevalent liver condition in the West&#46; The prevalence and severity of NAFLD is higher and the prognosis worse in patients with psoriasis&#46; The pathogenic link between psoriasis and NAFLD is chronic inflammation and peripheral insulin resistance&#44; a common finding in diseases associated with psoriasis&#46; NAFLD should therefore be ruled out during the initial evaluation of patients with psoriasis&#44; in particular if they show signs of metabolic syndrome and require systemic treatment&#46; Concomitant psoriasis and NAFLD and the likelihood of synergy between them place limitations on general recommendations and treatment for these patients given the potential for liver toxicity&#46; As hepatotoxic risk is associated with some of the conventional drugs used in this setting &#40;e&#46;g&#46;&#44; acitretin&#44; methotrexate&#44; and ciclosporin&#41;&#44; patients prescribed these treatments should be monitored as appropriate&#46; Anti-tumor necrosis factor agents hold the promise of potential benefits based on their effects on the inflammatory process and improving peripheral insulin resistance&#46; However&#44; cases of liver toxicity have also been reported in relation to these biologics&#46; No evidence has emerged to suggest that anti-p40 or anti-interleukin 17 agents provide benefits or have adverse effects&#46;</p></span>"
      ]
      "es" => array:2 [
        "titulo" => "Resumen"
        "resumen" => "<span id="abst0010" class="elsevierStyleSection elsevierViewall"><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">El h&#237;gado graso no alcoh&#243;lico es la principal causa de enfermedad hep&#225;tica en nuestro medio&#46; Los pacientes con psoriasis presentan mayor prevalencia y gravedad y peor pron&#243;stico de esta hepatopat&#237;a&#46; El v&#237;nculo patog&#233;nico entre ambas es el estado de inflamaci&#243;n cr&#243;nica y la resistencia perif&#233;rica a la insulina&#44; habitual en las comorbilidades asociadas a la psoriasis&#46; Por este motivo&#44; en la evaluaci&#243;n de los pacientes con psoriasis&#44; en particular si existen componentes del s&#237;ndrome metab&#243;lico y se requiere tratamiento sist&#233;mico&#44; se recomienda descartar esta posibilidad&#46; La coexistencia de psoriasis e h&#237;gado graso no alcoh&#243;lico&#44; con probable sinergia entre ambos&#44; condiciona las medidas generales que deben recomendarse en estos pacientes y tambi&#233;n la estrategia terap&#233;utica&#44; por la potencial hepatotoxicidad de algunos de ellos&#46; En este sentido&#44; algunos de los f&#225;rmacos convencionales habituales como acitretino&#44; metotrexato o ciclosporina presentan potenciales efectos hepatot&#243;xicos cuya repercusi&#243;n en cada paciente debe evaluarse de forma individualizada&#46; Los f&#225;rmacos anti-TNF podr&#237;an tener efectos beneficiosos fundamentados en el buen control del proceso inflamatorio y de una mejor&#237;a de la resistencia perif&#233;rica a la insulina&#46; Sin embargo&#44; se han descrito casos de hepatotoxicidad en algunos pacientes&#46; No existe evidencia de efectos beneficiosos o perjudiciales de los f&#225;rmacos anti p40 o anti IL-17&#46;</p></span>"
      ]
    ]
    "NotaPie" => array:1 [
      0 => array:2 [
        "etiqueta" => "&#9734;"
        "nota" => "<p class="elsevierStyleNotepara" id="npar0015">Please cite this article as&#58; Carrascosa JM&#44; Bonanad C&#44; Dauden E&#44; Botella R&#44; Olveira-Mart&#237;n A&#44; en nombre del Grupo de Trabajo en Inflamaci&#243;n Sist&#233;mica en Psoriasis&#46; Psoriasis e h&#237;gado graso no alcoh&#243;lico&#46; Actas Dermosifiliogr&#46; 2017&#59;108&#58;506&#8211;514&#46;</p>"
      ]
    ]
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      0 => array:7 [
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        "etiqueta" => "Figure 1"
        "tipo" => "MULTIMEDIAFIGURA"
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        "figura" => array:1 [
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        "descripcion" => array:1 [
          "en" => "<p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Nonalcoholic fatty liver disease &#40;NAFLD&#41; in patients with psoriasis&#46; Adapted from clinical guidelines&#46;<a class="elsevierStyleCrossRef" href="#bib0385"><span class="elsevierStyleSup">17</span></a></p> <p id="spar0020" class="elsevierStyleSimplePara elsevierViewall"><span class="elsevierStyleSup">a</span> Aspartate transaminase &#40;ASP&#41;&#44; alanine transaminase &#40;ALT&#41;&#44; and &#947;-glutamyltransferase &#40;GGT&#41;&#46;</p> <p id="spar0025" class="elsevierStyleSimplePara elsevierViewall"><span class="elsevierStyleSup">b</span>Any increase in ASP&#44; ALT&#44; and&#47;or GGT&#46;</p>"
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      1 => array:8 [
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        "etiqueta" => "Table 1"
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          "leyenda" => "<p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">Abbreviations&#58; ALT&#44; alanine transaminase&#59; AST&#44; aspartate transaminase&#59; BMI&#44; body mass index&#59; NAFLD&#44; nonalcoholic fatty liver disease&#46;</p>"
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                0 => """
                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">NAFLD Fibrosis Score<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>&#8211;1&#46;675<span class="elsevierStyleHsp" style=""></span>&#43;<span class="elsevierStyleHsp" style=""></span>0&#46;037<span class="elsevierStyleHsp" style=""></span>&#215;<span class="elsevierStyleHsp" style=""></span>age in y<span class="elsevierStyleHsp" style=""></span>&#43;<span class="elsevierStyleHsp" style=""></span>0&#46;094<span class="elsevierStyleHsp" style=""></span>&#215;<span class="elsevierStyleHsp" style=""></span>BMI &#40;kg&#47;m<span class="elsevierStyleSup">2</span>&#41;<span class="elsevierStyleHsp" style=""></span>&#43;<span class="elsevierStyleHsp" style=""></span>1&#46;13<span class="elsevierStyleHsp" style=""></span>&#215;<span class="elsevierStyleHsp" style=""></span>glucose intolerance or diabetes &#40;yes<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>1&#44; no<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#41;<span class="elsevierStyleHsp" style=""></span>&#43;<span class="elsevierStyleHsp" style=""></span>0&#46;99<span class="elsevierStyleHsp" style=""></span>&#215;<span class="elsevierStyleHsp" style=""></span>AST&#47;ALT ratio&#8211;0&#46;013<span class="elsevierStyleHsp" style=""></span>&#215;<span class="elsevierStyleHsp" style=""></span>platelet count &#40;&#215;<span class="elsevierStyleHsp" style=""></span>10<span class="elsevierStyleSup">9</span>&#47;L&#41;&#8211;0&#46;66<span class="elsevierStyleHsp" style=""></span>&#215;<span class="elsevierStyleHsp" style=""></span>albumin &#40;g&#47;dL&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Calculator available from&#58; http&#58;&#47;&#47;nafldscore&#46;com&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>A score &#60;<span class="elsevierStyleHsp" style=""></span>&#8211;1&#46;455 predicts low risk for advanced fibrosis&#46;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>A score &#62;<span class="elsevierStyleHsp" style=""></span>0&#46;676 predicts advanced fibrosis&#46;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Risk is indeterminate if the score falls between &#8211;1&#46;455 and 0&#46;676&#46;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
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            0 => array:3 [
              "identificador" => "tblfn0005"
              "etiqueta" => "a"
              "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Adapted from Angulo et al&#46;<a class="elsevierStyleCrossRef" href="#bib0375"><span class="elsevierStyleSup">15</span></a></p>"
            ]
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">Formula for the NAFLD Fibrosis Score and Risk Interpretation <a class="elsevierStyleCrossRef" href="#tblfn0005"><span class="elsevierStyleSup">a</span></a></p>"
        ]
      ]
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        "identificador" => "tbl0010"
        "etiqueta" => "Table 2"
        "tipo" => "MULTIMEDIATABLA"
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          "leyenda" => "<p id="spar0045" class="elsevierStyleSimplePara elsevierViewall">Abbreviations&#58; ALT&#44; alanine transaminase&#59; AST&#44; aspartate transaminase&#59; CRP&#44; C-reactive protein&#59; NAFLD&#44; nonalcoholic fatty liver disease&#59; OR&#44; odds ratio&#59; PASI&#44; Psoriasis Area and Severity Index&#46;</p>"
          "tablatextoimagen" => array:1 [
            0 => array:2 [
              "tabla" => array:1 [
                0 => """
                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Authors&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Study Population&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Psoriasis&#44; n&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">No Psoriasis&#44; n&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Findings&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Ethnicity&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Roberts et al&#46;<a class="elsevierStyleCrossRef" href="#bib0450"><span class="elsevierStyleSup">30</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Patients with psoriasis or psoriatic arthritis&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">103&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">NAFLD prevalence&#44; 47&#37;&#46; Steatohepatitis in 22&#37; of patients with NAFLD&#46;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Caucasians&#44; Latin Americans&#44; African Americans&#44; Asians&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Gisondi et al&#46;<a class="elsevierStyleCrossRef" href="#bib0425"><span class="elsevierStyleSup">25</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Hospitalized dermatology patients&#59;<br>controls&#44; hospital staff&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">130&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">260&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">NAFLD prevalence higher in psoriasis patients &#40;47&#37;&#41; than controls &#40;28&#37;&#41; &#40;<span class="elsevierStyleItalic">P</span><span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>&#46;0001&#41;&#46; Metabolic syndrome and elevated CRP levels more prevalent in patients with psoriasis and NAFLD &#40;n<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>61&#41;&#44; who also had higher mean &#40;SD&#41; PASI levels&#58; 14&#46;2 &#40;12&#46;6&#41; vs 9&#46;6 &#40;7&#46;4&#41; for patients without NAFLD &#40;n<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>69&#41; &#40;<span class="elsevierStyleItalic">P</span><span class="elsevierStyleHsp" style=""></span>&#60;&#46;01&#41;&#46;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Not reported<br>&#40;Caucasians&#63;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Miele et al&#46;<a class="elsevierStyleCrossRef" href="#bib0430"><span class="elsevierStyleSup">26</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Patients with psoriasis&#59; patients with NAFLD without psoriasis&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">142&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">125&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">59&#46;2&#37; were diagnosed with NAFLD&#46; Metabolic syndrome&#44; obesity&#44; dyslipidemia&#44; elevated AST&#47;ALT ratio&#44; and psoriatic arthritis frequencies were higher in patients with both psoriasis and NAFLD&#46; NAFLD patients with psoriasis had more severe liver disease than patients without psoriasis&#46;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Not reported<br>&#40;Caucasians&#63;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Abedini et al&#46;<a class="elsevierStyleCrossRef" href="#bib0440"><span class="elsevierStyleSup">28</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Patients with psoriasis vs healthy controls&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">123&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">123&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Prevalence of NAFLD was higher in psoriasis patients &#40;65&#46;6&#37; vs 35&#37; in controls&#41; &#40;<span class="elsevierStyleItalic">P</span><span class="elsevierStyleHsp" style=""></span>&#60;&#46;01&#44; OR<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>3&#46;53&#41;&#46;<br>Moderately severe NAFLD &#40;grade 2&#41; was more common than mild NAFLD &#40;grade 1&#41; &#40;<span class="elsevierStyleItalic">P</span><span class="elsevierStyleHsp" style=""></span>&#60;&#46;01&#41; in psoriasis patients&#46; Higher rates of hypertension &#40;16&#46;5&#37;&#41;&#44; altered liver function &#40;16&#46;4&#37;&#41;&#44; and metabolic syndrome &#40;46&#46;6&#37;&#41; also found in patients with psoriasis and NAFLD&#46;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Not reported<br>&#40;Caucasians&#63;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">van der Voort et al&#46;<a class="elsevierStyleCrossRef" href="#bib0435"><span class="elsevierStyleSup">27</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Patients &#62;55 years with NAFLD and psoriasis vs NAFLD patients without psoriasis&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">118&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">2174&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">46&#46;2&#37; had NAFLD and psoriasis&#59; 33&#37;&#44; only NAFLD&#46; Psoriasis continued to be a predictor of NAFLD after controlling for alcohol consumption&#44; ALT level&#44; and presence of metabolic syndrome&#46;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">95&#37; Caucasian&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
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        "descripcion" => array:1 [
          "en" => "<p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">Main Findings of Studies on the Prevalence and Features of NAFLD in Psoriasis&#46;</p>"
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      3 => array:8 [
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        "etiqueta" => "Table 3"
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          "leyenda" => "<p id="spar0055" class="elsevierStyleSimplePara elsevierViewall">Abbreviation&#58; HDL&#44; high-density lipoprotein&#46;</p>"
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                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Waist circumference <span class="elsevierStyleHsp" style=""></span>&#8805;<span class="elsevierStyleHsp" style=""></span>94<span class="elsevierStyleHsp" style=""></span>cm &#40;&#9794;&#41;&#44;<span class="elsevierStyleHsp" style=""></span>&#8805;<span class="elsevierStyleHsp" style=""></span>80<span class="elsevierStyleHsp" style=""></span>cm &#40;&#9792;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Blood pressure<span class="elsevierStyleHsp" style=""></span>&#8805;<span class="elsevierStyleHsp" style=""></span>130&#47;85<span class="elsevierStyleHsp" style=""></span>mm<span class="elsevierStyleHsp" style=""></span>Hg or on antihypertensive treatment&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Fasting glucose<span class="elsevierStyleHsp" style=""></span>&#8805;<span class="elsevierStyleHsp" style=""></span>100<span class="elsevierStyleHsp" style=""></span>mg&#47;dL or in treatment for type 2 diabetes mellitus&nbsp;\t\t\t\t\t\t\n
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          "en" => "<p id="spar0050" class="elsevierStyleSimplePara elsevierViewall">Risk Factors for Metabolic Syndrome&#160;<a class="elsevierStyleCrossRef" href="#tblfn0010"><span class="elsevierStyleSup">a</span></a></p>"
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          "textoCompleto" => "<span class="elsevierStyleSections"><span id="sec0045" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0065">Key Points</span><p id="par0135" class="elsevierStylePara elsevierViewall"><ul class="elsevierStyleList" id="lis0005"><li class="elsevierStyleListItem" id="lsti0005"><span class="elsevierStyleLabel">-</span><p id="par0140" class="elsevierStylePara elsevierViewall">The incidence of NAFLD is 1&#46;5- to 3-fold higher in psoriasis patients than in the nonpsoriatic population&#44; meaning we can expect to find NAFLD in roughly half of our patients with psoriasis&#46; The prevalence of steatohepatitis is also higher in psoriasis&#46;</p></li><li class="elsevierStyleListItem" id="lsti0010"><span class="elsevierStyleLabel">-</span><p id="par0145" class="elsevierStylePara elsevierViewall">Prognosis in NAFLD is affected by the presence and severity of steatohepatitis and liver fibrosis&#46;</p></li><li class="elsevierStyleListItem" id="lsti0015"><span class="elsevierStyleLabel">-</span><p id="par0150" class="elsevierStylePara elsevierViewall">Abdominal ultrasound screening is recommended in patients with insulin resistance or signs of metabolic syndrome and moderate to severe psoriasis&#44; even in the absence of abnormal liver enzymes&#46;</p></li><li class="elsevierStyleListItem" id="lsti0020"><span class="elsevierStyleLabel">-</span><p id="par0155" class="elsevierStylePara elsevierViewall">Patients with NAFLD should be referred to a specialist for evaluation and follow-up&#46;</p></li><li class="elsevierStyleListItem" id="lsti0025"><span class="elsevierStyleLabel">-</span><p id="par0160" class="elsevierStylePara elsevierViewall">A fatty liver limits therapeutic options and makes it advisable to tailor monitoring in patients taking potentially hepatotoxic drugs&#46;</p></li><li class="elsevierStyleListItem" id="lsti0030"><span class="elsevierStyleLabel">-</span><p id="par0165" class="elsevierStylePara elsevierViewall">Anti-TNF biologics offer theoretical benefits for patients with NAFLD as a result of better control of the inflammatory process and peripheral insulin resistance&#46; Ustekinumab and secukinumab do not seem to affect NAFLD adversely&#46;</p></li></ul></p></span></span>"
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                  ]
                  "host" => array:1 [
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                      "autores" => array:1 [
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                            0 => "F&#46; Higuera-de la Tijera"
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                            0 => "S&#46; Zelber-Sagi"
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                        0 => array:2 [
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                            0 => "R&#46;J&#46; Wong"
                            1 => "M&#46; Aguilar"
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                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1053/j.gastro.2014.11.039"
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            8 => array:3 [
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                0 => array:2 [
                  "contribucion" => array:1 [
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                      "titulo" => "Steatosis among living liver donors without evidence of fatty liver on ultrasonography&#58; Potential implications for preoperative liver biopsy"
                      "autores" => array:1 [
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Review
Psoriasis and Nonalcoholic Fatty Liver Disease
Psoriasis e hígado graso no alcohólico
J.M. Carrascosaa,
Autor para correspondencia
jmcarrascosac@hotmail.com

Corresponding author.
, C. Bonanadb, E. Daudenc, R. Botellad, A. Olveira-Martíne, on behalf of the Systemic Inflammation in Psoriasis Working Group
a Servicio de Dermatologia, Hospital Universitari Germans Trias i Pujol. Universitat Autònoma de Barcelona, Badadalona, Spain
b Servicio de Cardiología, Hospital Clínico Universitario, Valencia, Spain
c Servicio de Dermatología, Hospital La Princesa, Madrid, Spain
d Servicio de Dermatología, Hospital Universitario La Fe, Valencia, Spain
e Servicio de Aparato Digestivo, Hospital la Paz, Madrid, Spain
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          "en" => "<p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Nonalcoholic fatty liver disease &#40;NAFLD&#41; in patients with psoriasis&#46; Adapted from clinical guidelines&#46;<a class="elsevierStyleCrossRef" href="#bib0385"><span class="elsevierStyleSup">17</span></a></p> <p id="spar0020" class="elsevierStyleSimplePara elsevierViewall"><span class="elsevierStyleSup">a</span> Aspartate transaminase &#40;ASP&#41;&#44; alanine transaminase &#40;ALT&#41;&#44; and &#947;-glutamyltransferase &#40;GGT&#41;&#46;</p> <p id="spar0025" class="elsevierStyleSimplePara elsevierViewall"><span class="elsevierStyleSup">b</span>Any increase in ASP&#44; ALT&#44; and&#47;or GGT&#46;</p>"
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nearly all patients diagnosed with NAFLD share the characteristics associated with metabolic risk&#44; such as obesity&#44; type 2 diabetes mellitus&#44; hypertension&#44; and dyslipidemia&#46; NAFLD and metabolic syndrome share the pathophysiologic mechanism of insulin resistance&#46;<a class="elsevierStyleCrossRef" href="#bib0310"><span class="elsevierStyleSup">2</span></a></p><p id="par0010" class="elsevierStylePara elsevierViewall">Two histologic forms of the disease can be distinguished&#58; one is steatosis&#44; in which fat has been deposited but liver cells are not yet damaged&#44; and the other is steatohepatitis&#44; which is characterized by liver inflammation that can eventually lead to fibrosis&#46; Mortality is higher in patients with NAFLD than in the general population&#44; regardless of which of these histologic variants is present&#59; the cause of death is usually cardiovascular disease&#46;<a class="elsevierStyleCrossRef" href="#bib0315"><span class="elsevierStyleSup">3</span></a> Because steatohepatitis is an inflammatory condition&#44; the liver is threatened&#44; and 15&#37; to 25&#37; of patients will have progressed to cirrhosis within 10 years&#46; Once cirrhosis develops&#44; complications &#40;liver failure&#44; esophageal varices&#44; and liver cancer&#41; will lead to death in 25&#37; of affected patients within 5 years&#46;<a class="elsevierStyleCrossRef" href="#bib0320"><span class="elsevierStyleSup">4</span></a> Why fat deposition causes inflammation and fibrosis in some patients but not others is poorly understood&#44; although genetic and environmental factors are probably both relevant&#46;<a class="elsevierStyleCrossRef" href="#bib0325"><span class="elsevierStyleSup">5</span></a></p><p id="par0015" class="elsevierStylePara elsevierViewall">NAFLD is important in the West because it is currently the most prevalent liver disorder&#46; Approximately 20&#37; of adults in the general population have NAFLD&#44; and among them about 20&#37; have the aggressive form&#44; steatohepatitis&#46;<a class="elsevierStyleCrossRef" href="#bib0330"><span class="elsevierStyleSup">6</span></a> The prevalence is much higher among adults with metabolic syndrome&#44; where 38&#37; of overweight persons &#40;with a body mass index &#91;BMI&#93; between 25 and 30&#41; have NAFLD&#46; The prevalence rates in obese &#40;BMI&#44; 30&#8211;40&#41; and severely obese &#40;BMI&#44; 40&#8211;45&#41; persons are 46&#37; and 65&#37;&#44; respectively&#46; Finally&#44; some 90&#37; of morbidly obese patients &#40;BMI<span class="elsevierStyleHsp" style=""></span>&#62;<span class="elsevierStyleHsp" style=""></span>45&#41; have this condition&#44; and 5&#37; of them have cirrhosis&#46; Among diabetics&#44; the prevalence is 69&#37;&#44; and among patients with elevated triglyceride levels&#44; 50&#37;&#46;<a class="elsevierStyleCrossRef" href="#bib0335"><span class="elsevierStyleSup">7</span></a> A sign of the seriousness of this situation is that nonalcoholic steatohepatitis is currently the second most common cause of liver transplantation in the United States&#44; and it is expected to become the first cause in the coming years&#46;<a class="elsevierStyleCrossRef" href="#bib0340"><span class="elsevierStyleSup">8</span></a></p><p id="par0020" class="elsevierStylePara elsevierViewall">In spite of these statistics&#44; NAFLD is clearly underdiagnosed because there are no signs or symptoms that arouse suspicion except when the disease becomes advanced and also because serum biochemical markers show only slight&#44; nonspecific changes&#59; results may even stay within the normal limits in 15&#37; to 39&#37; of patients&#46;<a class="elsevierStyleCrossRefs" href="#bib0345"><span class="elsevierStyleSup">9&#44;10</span></a></p><p id="par0025" class="elsevierStylePara elsevierViewall">A diagnosis of NAFLD requires evidence of steatosis by liver biopsy or imaging and the exclusion of alcohol consumption or other general causes of liver disease or conditions that lead to steatosis&#46;<a class="elsevierStyleCrossRef" href="#bib0305"><span class="elsevierStyleSup">1</span></a> The first criterion&#8212;evidence of steatosis&#8212;is critical&#46; The list of causes of liver disease are well established<a class="elsevierStyleCrossRef" href="#bib0355"><span class="elsevierStyleSup">11</span></a> while the alternative causes of steatosis are very rare and&#44; in principle&#44; relatively easy to identify&#46; A liver biopsy is the gold standard&#44; but it is invasive&#44; has associated risk of complications and death&#44; and is costly&#46;<a class="elsevierStyleCrossRef" href="#bib0360"><span class="elsevierStyleSup">12</span></a> Furthermore&#44; it is not reasonable or even feasible to biopsy 20&#37; of the population&#46; Interest in finding a noninvasive approach to diagnosis is therefore growing&#46; A fatty liver is usually detected through imaging &#40;ultrasound&#44; computed tomography scans&#44; or nuclear magnetic resonance&#41;&#59; the sensitivity and specificity of images are 60&#37; and 94&#37;&#44; respectively&#46;<a class="elsevierStyleCrossRefs" href="#bib0365"><span class="elsevierStyleSup">13&#44;14</span></a> Ultrasound is usually chosen because it is innocuous and widely available&#46;<a class="elsevierStyleCrossRef" href="#bib0305"><span class="elsevierStyleSup">1</span></a> However&#44; neither liver enzymes nor images can distinguish between steatosis and steatohepatitis&#46; Nor can they establish or rule out the presence of fibrosis&#46; Various scoring systems using the results of serum tests have therefore been developed&#46; The most widely accepted is the NAFLD fibrosis score&#44;<a class="elsevierStyleCrossRef" href="#bib0375"><span class="elsevierStyleSup">15</span></a> which is calculated according to a formula &#40;<a href="http://nafldscore.com/">http&#58;&#47;&#47;nafldscore&#46;com</a>&#41; based on easy-to-obtain measurements&#58; BMI&#59; age&#59; platelet count&#59; and serum albumin&#44; aspartate transaminase &#40;AST&#41;&#44; and alanine transaminase &#40;ALT&#41; &#40;<a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a>&#41;&#46; Moreover&#44; this score is highly sensitive &#40;67&#37;&#41; and specific &#40;60&#37;&#41; for excluding &#40;67&#37;&#41; or detecting &#40;97&#37;&#41; the presence of advanced fibrosis using an area under the receiver operating characteristic curve of 0&#46;85 as the cutoff&#46; The severity of liver damage can also potentially be assessed by measuring liver stiffness indirectly with elastography&#46; The usefulness of this approach would mainly be to identify patients at low risk of advanced fibrosis or cirrhosis given the test&#39;s lack of precision when disease is advanced&#46;<a class="elsevierStyleCrossRef" href="#bib0380"><span class="elsevierStyleSup">16</span></a></p><elsevierMultimedia ident="tbl0005"></elsevierMultimedia><p id="par0030" class="elsevierStylePara elsevierViewall">The European Association for the Study of the Liver&#44; the European Association for the Study of Diabetes&#44; and the European Association for the Study of Obesity have recently published new joint guidelines for managing NAFLD&#46;<a class="elsevierStyleCrossRef" href="#bib0385"><span class="elsevierStyleSup">17</span></a> They recommend that all patients with insulin resistance or risk factors for metabolic syndrome be screened for NAFLD by ultrasound and liver biochemistry&#46; Any increase in AST&#44; ALT&#44; and&#47;or &#947;-glutamyltransferase are relevant&#44; regardless of magnitude&#46; The screening algorithm is shown in <a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>&#46;<a class="elsevierStyleCrossRef" href="#bib0385"><span class="elsevierStyleSup">17</span></a></p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0030">Therapeutic Management of NAFLD</span><p id="par0035" class="elsevierStylePara elsevierViewall">At this time there is no specific treatment for NAFLD available&#46; Weight loss of at least 7&#37; to 10&#37; and exercise are associated with histologic improvement&#44;<a class="elsevierStyleCrossRef" href="#bib0390"><span class="elsevierStyleSup">18</span></a> but they are difficult to achieve and particularly difficult to maintain long-term&#46; Alcohol&#44; saturated fats&#44; and fructose-sweetened beverages should be avoided&#46;<a class="elsevierStyleCrossRef" href="#bib0395"><span class="elsevierStyleSup">19</span></a> Coffee consumption&#44; on the other hand&#44; can be recommended&#46;<a class="elsevierStyleCrossRef" href="#bib0400"><span class="elsevierStyleSup">20</span></a> Several drugs &#40;metformin&#44; pioglitazone&#44; eicosapentenoic acid&#44; statins&#44; and vitamin E&#41; have been tried&#44; but there is a lack of sufficient evidence on which to base a strong recommendation&#46;<a class="elsevierStyleCrossRefs" href="#bib0305"><span class="elsevierStyleSup">1&#44;6&#44;21&#8211;24</span></a></p></span></span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0035">NAFLD and Psoriasis</span><p id="par0040" class="elsevierStylePara elsevierViewall">The first observational studies showing an association between NAFLD and psoriasis began to appear during the last 10 years&#44;<a class="elsevierStyleCrossRefs" href="#bib0425"><span class="elsevierStyleSup">25&#44;26</span></a> and the association has since been confirmed&#46;<a class="elsevierStyleCrossRefs" href="#bib0435"><span class="elsevierStyleSup">27&#44;28</span></a> Gisondi<span class="elsevierStyleHsp" style=""></span>et<span class="elsevierStyleHsp" style=""></span>al&#46;<a class="elsevierStyleCrossRef" href="#bib0425"><span class="elsevierStyleSup">25</span></a> saw a higher rate of ultrasound-diagnosed NAFLD &#40;47&#37;&#41; in a series of 130 consecutive patients with psoriasis than in 260 healthy controls &#40;28&#37;&#41; matched for age&#44; sex&#44; and BMI&#46; The psoriasis patients were also more likely to have metabolic syndrome and higher C-reactive protein levels&#59; those who also had NAFLD had higher interleukin &#40;IL&#41; 6 and lower adiponectin levels than those without the disease&#46; Abedini<span class="elsevierStyleHsp" style=""></span>et<span class="elsevierStyleHsp" style=""></span>al&#46;<a class="elsevierStyleCrossRef" href="#bib0440"><span class="elsevierStyleSup">28</span></a> reported finding NAFLD in 65&#46;6&#37; of patients with psoriasis &#40;vs 35&#37; of healthy controls&#41;&#44; and van<span class="elsevierStyleHsp" style=""></span>der<span class="elsevierStyleHsp" style=""></span>Voort<span class="elsevierStyleHsp" style=""></span>et<span class="elsevierStyleHsp" style=""></span>al&#46;<a class="elsevierStyleCrossRef" href="#bib0435"><span class="elsevierStyleSup">27</span></a> found that 46&#46;2&#37; of psoriatic patients and 33&#46;3&#37; of controls had NAFLD in a population-based series of 2292 persons over the age of 55 years in Rotterdam&#46; These findings may be attributable to the association between psoriasis and metabolic syndrome&#44; given that the conditions defining the latter are those that lead to NAFLD&#46;<a class="elsevierStyleCrossRef" href="#bib0445"><span class="elsevierStyleSup">29</span></a> Miele<span class="elsevierStyleHsp" style=""></span>et<span class="elsevierStyleHsp" style=""></span>al&#46;<a class="elsevierStyleCrossRef" href="#bib0430"><span class="elsevierStyleSup">26</span></a> studied a cohort of psoriasis patients with and without NAFLD&#44; finding that NAFLD was also associated with psoriatic arthritis&#46; Roberts<span class="elsevierStyleHsp" style=""></span>et<span class="elsevierStyleHsp" style=""></span>al&#46;<a class="elsevierStyleCrossRef" href="#bib0450"><span class="elsevierStyleSup">30</span></a> reported finding a relationship between greater severity of psoriasis and NAFLD&#46; Specifically&#44; they saw steatohepatitis in 22&#37; of the patients with both psoriasis and NAFLD who underwent liver biopsy&#46; The NAFLD patients with steatohepatitis were also more likely to be obese and have higher insulin and transaminase levels&#59; they also found marked differences in risk for NAFLD according to ethnic origin&#46; Similarly&#44; van<span class="elsevierStyleHsp" style=""></span>der<span class="elsevierStyleHsp" style=""></span>Voort<span class="elsevierStyleHsp" style=""></span>et<span class="elsevierStyleHsp" style=""></span>al&#46;<a class="elsevierStyleCrossRef" href="#bib0435"><span class="elsevierStyleSup">27</span></a> found that patients of Latin American origin carried greater risk &#40;83&#37;&#41;&#44; followed by Caucasians &#40;39&#37;&#41;&#44; and finally African Americans &#40;33&#37;&#41;&#46;</p><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0040">Clinical Suspicion and Screening for NAFLD in Dermatology</span><p id="par0045" class="elsevierStylePara elsevierViewall">A high index of suspicion concerning NAFLD is needed in dermatology because most cases encountered will be asymptomatic&#46; The dermatologist should above all be aware of the high prevalence in patients with psoriasis&#46; It is also important to note signs of the components of metabolic syndrome&#58; diabetes mellitus&#44; obesity&#44; dyslipidemia&#44; and hypertension&#46; Abnormal liver enzymes may be difficult to discern because elevations are usually slight&#44; at less than 2- to 3-fold the normal values and with an ALT&#47;AST ratio greater than 1&#59; alkaline phosphatase and &#947;-glutamyltransferase are occasionally elevated&#46;<a class="elsevierStyleCrossRef" href="#bib0455"><span class="elsevierStyleSup">31</span></a> Liver enzymes can be normal in 15&#37; to 30&#37; or more of patients with NAFLD&#44;<a class="elsevierStyleCrossRef" href="#bib0350"><span class="elsevierStyleSup">10</span></a> even though 35&#37; of such patients have advanced fibrosis or cirrhosis&#46; Given this situation&#44; in the presence of the most prevalent indicator of risk for NAFLD&#8212;namely components of metabolic syndrome&#8212;ultrasound imaging to rule out liver disease is indicated even when biochemistry is normal&#46;<a class="elsevierStyleCrossRef" href="#bib0385"><span class="elsevierStyleSup">17</span></a> At this time&#44; however&#44; the clinical algorithm recommended by most medical associations specializing in NAFLD &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>&#41;&#44; does not recognize the need for imaging to evaluate patients with psoriasis in the absence of liver enzyme abnormalities&#46;</p><p id="par0050" class="elsevierStylePara elsevierViewall">Once NAFLD has been confirmed&#44; the dermatologist must cooperate in prescribing the necessary dietary measures and adjusting drug dosages if transaminase levels are elevated&#46;</p><p id="par0055" class="elsevierStylePara elsevierViewall">The absence of liver damage according to the initial assessment does not exclude its development over the coming years&#46; Therefore&#44; patients will have to be reassessed if analyses reveal signs of damage or if metabolic syndrome develops&#46;<a class="elsevierStyleCrossRef" href="#bib0385"><span class="elsevierStyleSup">17</span></a></p></span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0045">Pathogenesis of NAFLD in Psoriasis</span><p id="par0060" class="elsevierStylePara elsevierViewall">This review does not attempt to delve deeply into the pathogenesis of NAFLD&#44; but it is useful to be aware of the two-hit hypothesis&#46;<a class="elsevierStyleCrossRef" href="#bib0460"><span class="elsevierStyleSup">32</span></a> In this theory&#44; the first phase would be marked by the abnormal accumulation of triglycerides in liver cells&#44; a development in which insulin resistance plays a large role&#46; In the second phase&#44; the steatotic liver appears to become susceptible to injury induced by several players and events involving various adipokines and oxidative stress in the endoplasmic reticulum&#44; as well as mitochondrial dysfunction and liver apoptosis&#46; These events favor the transition from simple steatosis to steatohepatitis&#46; Besides the involvement of insulin resistance in both these phases of progression toward NAFLD&#8212;as well as in the induction and activation of profibrotic cytokines&#8212;other chronic inflammatory processes that might be present&#44; such as psoriasis&#44; can contribute proinflammatory cytokines&#46;<a class="elsevierStyleCrossRef" href="#bib0465"><span class="elsevierStyleSup">33</span></a> Thus&#44; the pathogenic relationship between NAFLD and psoriasis is complex and probably multifactorial&#44; although it is presumably related to a state of chronic underlying inflammation&#46;</p><p id="par0065" class="elsevierStylePara elsevierViewall">NAFLD and psoriasis are probably linked partly because some of the conditions that often accompany psoriasis are also the ones that cause NAFLD&#46; Among them&#44; obesity stands out&#46; The epidemiologic association between obesity and psoriasis is clear&#44; particularly in severe psoriasis&#44; and the influences probably operate in both directions&#44; such that obesity favors psoriasis and vice versa&#46;<a class="elsevierStyleCrossRef" href="#bib0470"><span class="elsevierStyleSup">34</span></a> The prevalence of NAFLD is also clearly higher in obese patients&#44; especially those with excess abdominal fat&#44; which is more metabolically active than subcutaneous fat&#46;<a class="elsevierStyleCrossRef" href="#bib0475"><span class="elsevierStyleSup">35</span></a> Obesity is associated with risk for developing insulin resistance&#44; the main factor in the development of NAFLD&#46;<a class="elsevierStyleCrossRef" href="#bib0480"><span class="elsevierStyleSup">36</span></a> Excessive fat deposition leads to an imbalance between pro- and anti-inflammatory cytokines&#44; favoring the progression of liver disease&#46; When adipose tissue secretes an abundance of adipokines&#8212;tumor necrosis factor &#40;TNF&#41;&#44; IL-6&#44; leptin&#44; visfatin&#44; or resistin&#8212;a proinflammatory state may develop in psoriatic skin as the result of the proliferation of keratinocytes&#44; angiogenesis&#44; the response of type 1<span class="elsevierStyleHsp" style=""></span>T cells&#44; or the expression of adhesion molecules&#46; This state may also be expressed in NAFLD&#44; contributing to insulin resistance or liver fibrosis&#46; In addition&#44; there is also a decrease in the concentration of adipokines that protect against inflammation&#8212;such as adiponectin&#44; a promotor of skin anti-inflammatory cytokines that enhances insulin sensitivity&#46;<a class="elsevierStyleCrossRef" href="#bib0485"><span class="elsevierStyleSup">37</span></a></p><p id="par0070" class="elsevierStylePara elsevierViewall">The involvement of IL-17 in both psoriasis and NAFLD is interesting&#46; T cells in adipose tissue synthesize IL-17&#44; which is able to regulate adipogenesis and glucose metabolism&#46; Type 17<span class="elsevierStyleHsp" style=""></span>T helper cells and IL-17 could facilitate the progression from simple steatosis to steatohepatitis&#46;<a class="elsevierStyleCrossRef" href="#bib0490"><span class="elsevierStyleSup">38</span></a></p></span><span id="sec0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0050">Implications for the Management of Conventional Systemic Treatments</span><p id="par0075" class="elsevierStylePara elsevierViewall">The high prevalence of NAFLD in psoriasis leads to therapeutic concerns because this chronic skin disease must be treated over decades&#46;</p><p id="par0080" class="elsevierStylePara elsevierViewall">The incidence of MTX-induced liver damage is known to be higher in psoriasis<a class="elsevierStyleCrossRef" href="#bib0495"><span class="elsevierStyleSup">39</span></a> than in other chronic inflammatory diseases&#46; A recent retrospective study saw&#44; for example&#44; that 58&#37; of 710 patients on MTX for psoriasis had elevated transaminase levels&#46;<a class="elsevierStyleCrossRef" href="#bib0500"><span class="elsevierStyleSup">40</span></a> In the light of our current understanding&#44; this finding may be relevant to the known association between NAFLD and psoriasis&#46; Given the high rates of both NAFLD and steatohepatitis in this setting&#44; we should rule out significant steatosis before starting MTX&#44; at least in patients with signs of metabolic syndrome&#46; In addition to ultrasound screening&#44; two new tools&#44; the FibroTest and the FibroScan &#40;liver elastography&#41; may be useful for assessing liver fibrosis&#46;<a class="elsevierStyleCrossRef" href="#bib0505"><span class="elsevierStyleSup">41</span></a></p><p id="par0085" class="elsevierStylePara elsevierViewall">MTX toxicity presents with histologic findings and may therefore reflect pathogenic mechanisms that are different from those associated with NAFLD&#46; However&#44; the shared risk factors that aggravate both MTX toxicity and NAFLD&#8212;such as obesity&#44; diabetes&#44; or hyperlipidemia&#8212;are observed often in patients with severe psoriasis&#46;<a class="elsevierStyleCrossRef" href="#bib0510"><span class="elsevierStyleSup">42</span></a></p><p id="par0090" class="elsevierStylePara elsevierViewall">Liver toxicity is also among the potential adverse effects of ciclosporin&#46; The effect may be direct or it may be a byproduct of a deteriorating lipid profile&#46;<a class="elsevierStyleCrossRef" href="#bib0515"><span class="elsevierStyleSup">43</span></a> Acitretin can also raise triglyceride levels and has been associated with transaminase elevations in 1 out of 4 patients&#44; although tissue damage following intermittent use of the drug has not been reported&#46;<a class="elsevierStyleCrossRef" href="#bib0520"><span class="elsevierStyleSup">44</span></a></p></span></span><span id="sec0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0055">Biologic Agents in Patients With Psoriasis and NAFLD</span><p id="par0095" class="elsevierStylePara elsevierViewall">TNF plays a central role in the inflammatory process in NAFLD&#44; as in other chronic inflammatory diseases&#46;<a class="elsevierStyleCrossRef" href="#bib0525"><span class="elsevierStyleSup">45</span></a> In fact&#44; TNF has been studied for its potential use as a diagnostic and prognostic tool in NAFLD&#46;<a class="elsevierStyleCrossRef" href="#bib0530"><span class="elsevierStyleSup">46</span></a> Given the pathogenic role of this cytokine&#44; anti-TNF agents such as infliximab and adalimumab have also been tried in this setting<a class="elsevierStyleCrossRefs" href="#bib0535"><span class="elsevierStyleSup">47&#44;48</span></a> because of improvements observed in liver and metabolic biomarkers after biologic therapy for other inflammatory diseases&#46;<a class="elsevierStyleCrossRefs" href="#bib0545"><span class="elsevierStyleSup">49&#44;50</span></a></p><p id="par0100" class="elsevierStylePara elsevierViewall">Biologics have a better safety profile than the conventional treatments for NAFLD mentioned earlier&#46; For example&#44; when adalimumab was used for an average of 5 years in 32 patients with liver disease and psoriasis&#44; no cases of liver disease progression or development of liver toxicity were observed&#46;<a class="elsevierStyleCrossRef" href="#bib0555"><span class="elsevierStyleSup">51</span></a></p><p id="par0105" class="elsevierStylePara elsevierViewall">Biologic therapy could exercise regulatory effects on some adipocytokines&#46; Shibata<span class="elsevierStyleHsp" style=""></span>et<span class="elsevierStyleHsp" style=""></span>al&#46;<a class="elsevierStyleCrossRef" href="#bib0560"><span class="elsevierStyleSup">52</span></a> reported an increase in adiponectin and IL-6 levels during treatment with infliximab&#44; and adalimumab and etanercept may inhibit proinflammatory adipocytokines&#46;<a class="elsevierStyleCrossRef" href="#bib0565"><span class="elsevierStyleSup">53</span></a></p><p id="par0110" class="elsevierStylePara elsevierViewall">Studies of the impact of anti-TNF agents on the lipid profile&#44; a risk factor for NAFLD&#44; have yielded inconsistent results&#46; While some authors have not been able to demonstrate a significant effect&#44; others have reported elevated triglycerides and lower high-density lipoprotein &#40;HDL&#41; cholesterol levels in patients with infliximab-treated psoriatic arthritis&#46;<a class="elsevierStyleCrossRef" href="#bib0570"><span class="elsevierStyleSup">54</span></a> Etanercept therapy&#44; on the other hand&#44; has favorably modulated the antioxident and anti-inflammatory properties of HDL cholesterol as well as modulated adipolipoprotein A1 and B levels&#44; reducing lipid peroxidation&#46;<a class="elsevierStyleCrossRef" href="#bib0575"><span class="elsevierStyleSup">55</span></a></p><p id="par0115" class="elsevierStylePara elsevierViewall">Marra et al&#46;<a class="elsevierStyleCrossRef" href="#bib0580"><span class="elsevierStyleSup">56</span></a> showed improved insulin sensitivity in patients treated with etanercept for psoriasis&#44; an effect that could potentially have a favorable influence on the course of NAFLD&#46;</p><p id="par0120" class="elsevierStylePara elsevierViewall">It must be borne in mind that anti-TNF agents can occasionally induce autoimmune or drug-related hepatitis&#46;<a class="elsevierStyleCrossRef" href="#bib0585"><span class="elsevierStyleSup">57</span></a> The risk is very low&#44; however&#46; Only 20 cases of autoimmune hepatitis have ever been reported&#59; most were mild cases associated with infliximab and responded quickly to steroid treatment&#46;<a class="elsevierStyleCrossRef" href="#bib0505"><span class="elsevierStyleSup">41</span></a> Anti-TNF agents have also been linked to weight gain in psoriasis patients&#44; although the gains have generally been modest&#46; However&#44; long-term use has led to considerable gain in some patients&#44; and this adverse effect potentially aggravates the obesity associated with severe psoriasis and NAFLD&#46;<a class="elsevierStyleCrossRef" href="#bib0590"><span class="elsevierStyleSup">58</span></a></p><p id="par0125" class="elsevierStylePara elsevierViewall">High transaminase levels were detected in 6 patients in a series of 44 treated with ustekinumab for an average of 46&#46;7 months&#46;<a class="elsevierStyleCrossRef" href="#bib0595"><span class="elsevierStyleSup">59</span></a> Five of the 6 patients developed hepatotoxicity related to other drugs&#44; 3 developed fatty liver&#44; and 3 were receiving other hepatotoxic drugs while taking ustekinumab&#46; The authors concluded that ustekinumab-related toxicity was mild and uncommon&#46; Hepatotoxicity is not described as a side effect detected in clinical trials of secukinumab<a class="elsevierStyleCrossRef" href="#bib0600"><span class="elsevierStyleSup">60</span></a> &#40;<a class="elsevierStyleCrossRef" href="#tbl0010">Table 2</a>&#41;&#46;</p><elsevierMultimedia ident="tbl0010"></elsevierMultimedia></span><span id="sec0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0060">Conclusions</span><p id="par0130" class="elsevierStylePara elsevierViewall">NAFLD is the most frequent liver disorder in the West &#40;<a class="elsevierStyleCrossRef" href="#tbl0015">Table 3</a>&#41;&#46; Patients with psoriasis have a higher prevalence of NAFLD&#44; a higher rate of severe disease&#44; and a worse prognosis&#46; Dermatologists should routinely evaluate psoriasis patients for NAFLD&#46; The pathogenic links between psoriasis and NAFLD are chronic inflammation and peripheral insulin resistance&#44; which is a common finding in diseases associated with psoriasis&#46; The dermatologist should be aware not only of the high prevalence of NAFLD in psoriasis but also of the possibility of steatohepatitis&#44; especially when psoriasis is severe or when there are signs of metabolic syndrome&#46; Psoriasis patients with insulin resistance or risk factors for metabolic syndrome should be specifically evaluated for fatty liver by abdominal ultrasound and liver biochemistry&#46; Concurrent psoriasis and NAFLD&#44; and the likely synergy between them&#44; affect the general recommendations we can make and the treatment strategies we can adopt&#46; Some drugs carry risk of hepatotoxicity&#46; On the other hand&#44; there is a possibility that achieving good control of inflammation and pathogenic factors associated with NAFLD will improve the prognosis&#46;<elsevierMultimedia ident="tb0005"></elsevierMultimedia></p><elsevierMultimedia ident="tbl0015"></elsevierMultimedia></span><span id="sec0050" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0070">Ethical Disclosures</span><span id="sec0055" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0075">Protection of human and animal subjects</span><p id="par0170" class="elsevierStylePara elsevierViewall">The authors declare that no experiments were performed on humans or animals for this investigation&#46;</p></span><span id="sec0060" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0080">Data confidentiality</span><p id="par0175" class="elsevierStylePara elsevierViewall">The authors declare that no private patient data are disclosed in this article&#46;</p></span><span id="sec0065" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0085">Right to privacy and informed consent</span><p id="par0180" class="elsevierStylePara elsevierViewall">The authors declare that no private patient data are disclosed in this article&#46;</p></span></span><span id="sec0070" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0090">Conflicts of Interest</span><p id="par0185" class="elsevierStylePara elsevierViewall">Abbvie sponsored the meetings of the working group&#44; but no employees of the laboratory participated in the research&#44; interpretation&#44; discussion&#44; or drafting of the text&#46;</p><p id="par0190" class="elsevierStylePara elsevierViewall">J&#46; M&#46; Carrascosa has served as a consultant&#44; given invited talks&#44; and&#47;or participated in clinical trials sponsored by the following laboratories&#58; Abbvie&#44; Janssen&#44; Lilly&#44; Pfizer&#44; Novartis&#44; Pfizer&#44; and Celgene&#46;</p></span></span>"
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          "titulo" => "Nonalcoholic Fatty Liver Disease&#58; The Concept"
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              "titulo" => "Therapeutic Management of NAFLD"
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          "titulo" => "NAFLD and Psoriasis"
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            1 => "Nonalcoholic fatty liver disease"
            2 => "Steatosis"
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            0 => "Psoriasis"
            1 => "H&#237;gado graso no alcoh&#243;lico"
            2 => "Esteatosis"
            3 => "Tratamiento"
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        "resumen" => "<span id="abst0005" class="elsevierStyleSection elsevierViewall"><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Nonalcoholic fatty liver disease &#40;NAFLD&#41; is the most prevalent liver condition in the West&#46; The prevalence and severity of NAFLD is higher and the prognosis worse in patients with psoriasis&#46; The pathogenic link between psoriasis and NAFLD is chronic inflammation and peripheral insulin resistance&#44; a common finding in diseases associated with psoriasis&#46; NAFLD should therefore be ruled out during the initial evaluation of patients with psoriasis&#44; in particular if they show signs of metabolic syndrome and require systemic treatment&#46; Concomitant psoriasis and NAFLD and the likelihood of synergy between them place limitations on general recommendations and treatment for these patients given the potential for liver toxicity&#46; As hepatotoxic risk is associated with some of the conventional drugs used in this setting &#40;e&#46;g&#46;&#44; acitretin&#44; methotrexate&#44; and ciclosporin&#41;&#44; patients prescribed these treatments should be monitored as appropriate&#46; Anti-tumor necrosis factor agents hold the promise of potential benefits based on their effects on the inflammatory process and improving peripheral insulin resistance&#46; However&#44; cases of liver toxicity have also been reported in relation to these biologics&#46; No evidence has emerged to suggest that anti-p40 or anti-interleukin 17 agents provide benefits or have adverse effects&#46;</p></span>"
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        "resumen" => "<span id="abst0010" class="elsevierStyleSection elsevierViewall"><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">El h&#237;gado graso no alcoh&#243;lico es la principal causa de enfermedad hep&#225;tica en nuestro medio&#46; Los pacientes con psoriasis presentan mayor prevalencia y gravedad y peor pron&#243;stico de esta hepatopat&#237;a&#46; El v&#237;nculo patog&#233;nico entre ambas es el estado de inflamaci&#243;n cr&#243;nica y la resistencia perif&#233;rica a la insulina&#44; habitual en las comorbilidades asociadas a la psoriasis&#46; Por este motivo&#44; en la evaluaci&#243;n de los pacientes con psoriasis&#44; en particular si existen componentes del s&#237;ndrome metab&#243;lico y se requiere tratamiento sist&#233;mico&#44; se recomienda descartar esta posibilidad&#46; La coexistencia de psoriasis e h&#237;gado graso no alcoh&#243;lico&#44; con probable sinergia entre ambos&#44; condiciona las medidas generales que deben recomendarse en estos pacientes y tambi&#233;n la estrategia terap&#233;utica&#44; por la potencial hepatotoxicidad de algunos de ellos&#46; En este sentido&#44; algunos de los f&#225;rmacos convencionales habituales como acitretino&#44; metotrexato o ciclosporina presentan potenciales efectos hepatot&#243;xicos cuya repercusi&#243;n en cada paciente debe evaluarse de forma individualizada&#46; Los f&#225;rmacos anti-TNF podr&#237;an tener efectos beneficiosos fundamentados en el buen control del proceso inflamatorio y de una mejor&#237;a de la resistencia perif&#233;rica a la insulina&#46; Sin embargo&#44; se han descrito casos de hepatotoxicidad en algunos pacientes&#46; No existe evidencia de efectos beneficiosos o perjudiciales de los f&#225;rmacos anti p40 o anti IL-17&#46;</p></span>"
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        "nota" => "<p class="elsevierStyleNotepara" id="npar0015">Please cite this article as&#58; Carrascosa JM&#44; Bonanad C&#44; Dauden E&#44; Botella R&#44; Olveira-Mart&#237;n A&#44; en nombre del Grupo de Trabajo en Inflamaci&#243;n Sist&#233;mica en Psoriasis&#46; Psoriasis e h&#237;gado graso no alcoh&#243;lico&#46; Actas Dermosifiliogr&#46; 2017&#59;108&#58;506&#8211;514&#46;</p>"
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          "en" => "<p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Nonalcoholic fatty liver disease &#40;NAFLD&#41; in patients with psoriasis&#46; Adapted from clinical guidelines&#46;<a class="elsevierStyleCrossRef" href="#bib0385"><span class="elsevierStyleSup">17</span></a></p> <p id="spar0020" class="elsevierStyleSimplePara elsevierViewall"><span class="elsevierStyleSup">a</span> Aspartate transaminase &#40;ASP&#41;&#44; alanine transaminase &#40;ALT&#41;&#44; and &#947;-glutamyltransferase &#40;GGT&#41;&#46;</p> <p id="spar0025" class="elsevierStyleSimplePara elsevierViewall"><span class="elsevierStyleSup">b</span>Any increase in ASP&#44; ALT&#44; and&#47;or GGT&#46;</p>"
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          "leyenda" => "<p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">Abbreviations&#58; ALT&#44; alanine transaminase&#59; AST&#44; aspartate transaminase&#59; BMI&#44; body mass index&#59; NAFLD&#44; nonalcoholic fatty liver disease&#46;</p>"
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                  \t\t\t\t" class=""><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">NAFLD Fibrosis Score<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>&#8211;1&#46;675<span class="elsevierStyleHsp" style=""></span>&#43;<span class="elsevierStyleHsp" style=""></span>0&#46;037<span class="elsevierStyleHsp" style=""></span>&#215;<span class="elsevierStyleHsp" style=""></span>age in y<span class="elsevierStyleHsp" style=""></span>&#43;<span class="elsevierStyleHsp" style=""></span>0&#46;094<span class="elsevierStyleHsp" style=""></span>&#215;<span class="elsevierStyleHsp" style=""></span>BMI &#40;kg&#47;m<span class="elsevierStyleSup">2</span>&#41;<span class="elsevierStyleHsp" style=""></span>&#43;<span class="elsevierStyleHsp" style=""></span>1&#46;13<span class="elsevierStyleHsp" style=""></span>&#215;<span class="elsevierStyleHsp" style=""></span>glucose intolerance or diabetes &#40;yes<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>1&#44; no<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#41;<span class="elsevierStyleHsp" style=""></span>&#43;<span class="elsevierStyleHsp" style=""></span>0&#46;99<span class="elsevierStyleHsp" style=""></span>&#215;<span class="elsevierStyleHsp" style=""></span>AST&#47;ALT ratio&#8211;0&#46;013<span class="elsevierStyleHsp" style=""></span>&#215;<span class="elsevierStyleHsp" style=""></span>platelet count &#40;&#215;<span class="elsevierStyleHsp" style=""></span>10<span class="elsevierStyleSup">9</span>&#47;L&#41;&#8211;0&#46;66<span class="elsevierStyleHsp" style=""></span>&#215;<span class="elsevierStyleHsp" style=""></span>albumin &#40;g&#47;dL&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Calculator available from&#58; http&#58;&#47;&#47;nafldscore&#46;com&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>A score &#60;<span class="elsevierStyleHsp" style=""></span>&#8211;1&#46;455 predicts low risk for advanced fibrosis&#46;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>A score &#62;<span class="elsevierStyleHsp" style=""></span>0&#46;676 predicts advanced fibrosis&#46;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Risk is indeterminate if the score falls between &#8211;1&#46;455 and 0&#46;676&#46;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
              ]
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              "identificador" => "tblfn0005"
              "etiqueta" => "a"
              "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Adapted from Angulo et al&#46;<a class="elsevierStyleCrossRef" href="#bib0375"><span class="elsevierStyleSup">15</span></a></p>"
            ]
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">Formula for the NAFLD Fibrosis Score and Risk Interpretation <a class="elsevierStyleCrossRef" href="#tblfn0005"><span class="elsevierStyleSup">a</span></a></p>"
        ]
      ]
      2 => array:8 [
        "identificador" => "tbl0010"
        "etiqueta" => "Table 2"
        "tipo" => "MULTIMEDIATABLA"
        "mostrarFloat" => true
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          "leyenda" => "<p id="spar0045" class="elsevierStyleSimplePara elsevierViewall">Abbreviations&#58; ALT&#44; alanine transaminase&#59; AST&#44; aspartate transaminase&#59; CRP&#44; C-reactive protein&#59; NAFLD&#44; nonalcoholic fatty liver disease&#59; OR&#44; odds ratio&#59; PASI&#44; Psoriasis Area and Severity Index&#46;</p>"
          "tablatextoimagen" => array:1 [
            0 => array:2 [
              "tabla" => array:1 [
                0 => """
                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Authors&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Study Population&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Psoriasis&#44; n&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">No Psoriasis&#44; n&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Findings&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Ethnicity&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Roberts et al&#46;<a class="elsevierStyleCrossRef" href="#bib0450"><span class="elsevierStyleSup">30</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Patients with psoriasis or psoriatic arthritis&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">103&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">NAFLD prevalence&#44; 47&#37;&#46; Steatohepatitis in 22&#37; of patients with NAFLD&#46;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Caucasians&#44; Latin Americans&#44; African Americans&#44; Asians&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Gisondi et al&#46;<a class="elsevierStyleCrossRef" href="#bib0425"><span class="elsevierStyleSup">25</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Hospitalized dermatology patients&#59;<br>controls&#44; hospital staff&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">130&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">260&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">NAFLD prevalence higher in psoriasis patients &#40;47&#37;&#41; than controls &#40;28&#37;&#41; &#40;<span class="elsevierStyleItalic">P</span><span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>&#46;0001&#41;&#46; Metabolic syndrome and elevated CRP levels more prevalent in patients with psoriasis and NAFLD &#40;n<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>61&#41;&#44; who also had higher mean &#40;SD&#41; PASI levels&#58; 14&#46;2 &#40;12&#46;6&#41; vs 9&#46;6 &#40;7&#46;4&#41; for patients without NAFLD &#40;n<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>69&#41; &#40;<span class="elsevierStyleItalic">P</span><span class="elsevierStyleHsp" style=""></span>&#60;&#46;01&#41;&#46;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Not reported<br>&#40;Caucasians&#63;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Miele et al&#46;<a class="elsevierStyleCrossRef" href="#bib0430"><span class="elsevierStyleSup">26</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Patients with psoriasis&#59; patients with NAFLD without psoriasis&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">142&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">125&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">59&#46;2&#37; were diagnosed with NAFLD&#46; Metabolic syndrome&#44; obesity&#44; dyslipidemia&#44; elevated AST&#47;ALT ratio&#44; and psoriatic arthritis frequencies were higher in patients with both psoriasis and NAFLD&#46; NAFLD patients with psoriasis had more severe liver disease than patients without psoriasis&#46;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Not reported<br>&#40;Caucasians&#63;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Abedini et al&#46;<a class="elsevierStyleCrossRef" href="#bib0440"><span class="elsevierStyleSup">28</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Patients with psoriasis vs healthy controls&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">123&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">123&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Prevalence of NAFLD was higher in psoriasis patients &#40;65&#46;6&#37; vs 35&#37; in controls&#41; &#40;<span class="elsevierStyleItalic">P</span><span class="elsevierStyleHsp" style=""></span>&#60;&#46;01&#44; OR<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>3&#46;53&#41;&#46;<br>Moderately severe NAFLD &#40;grade 2&#41; was more common than mild NAFLD &#40;grade 1&#41; &#40;<span class="elsevierStyleItalic">P</span><span class="elsevierStyleHsp" style=""></span>&#60;&#46;01&#41; in psoriasis patients&#46; Higher rates of hypertension &#40;16&#46;5&#37;&#41;&#44; altered liver function &#40;16&#46;4&#37;&#41;&#44; and metabolic syndrome &#40;46&#46;6&#37;&#41; also found in patients with psoriasis and NAFLD&#46;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Not reported<br>&#40;Caucasians&#63;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">van der Voort et al&#46;<a class="elsevierStyleCrossRef" href="#bib0435"><span class="elsevierStyleSup">27</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Patients &#62;55 years with NAFLD and psoriasis vs NAFLD patients without psoriasis&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">118&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">2174&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">46&#46;2&#37; had NAFLD and psoriasis&#59; 33&#37;&#44; only NAFLD&#46; Psoriasis continued to be a predictor of NAFLD after controlling for alcohol consumption&#44; ALT level&#44; and presence of metabolic syndrome&#46;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">95&#37; Caucasian&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
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        "descripcion" => array:1 [
          "en" => "<p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">Main Findings of Studies on the Prevalence and Features of NAFLD in Psoriasis&#46;</p>"
        ]
      ]
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        "etiqueta" => "Table 3"
        "tipo" => "MULTIMEDIATABLA"
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          "leyenda" => "<p id="spar0055" class="elsevierStyleSimplePara elsevierViewall">Abbreviation&#58; HDL&#44; high-density lipoprotein&#46;</p>"
          "tablatextoimagen" => array:1 [
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                0 => """
                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Waist circumference <span class="elsevierStyleHsp" style=""></span>&#8805;<span class="elsevierStyleHsp" style=""></span>94<span class="elsevierStyleHsp" style=""></span>cm &#40;&#9794;&#41;&#44;<span class="elsevierStyleHsp" style=""></span>&#8805;<span class="elsevierStyleHsp" style=""></span>80<span class="elsevierStyleHsp" style=""></span>cm &#40;&#9792;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Blood pressure<span class="elsevierStyleHsp" style=""></span>&#8805;<span class="elsevierStyleHsp" style=""></span>130&#47;85<span class="elsevierStyleHsp" style=""></span>mm<span class="elsevierStyleHsp" style=""></span>Hg or on antihypertensive treatment&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Fasting glucose<span class="elsevierStyleHsp" style=""></span>&#8805;<span class="elsevierStyleHsp" style=""></span>100<span class="elsevierStyleHsp" style=""></span>mg&#47;dL or in treatment for type 2 diabetes mellitus&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Triglycerides<span class="elsevierStyleHsp" style=""></span>&#8805;<span class="elsevierStyleHsp" style=""></span>150<span class="elsevierStyleHsp" style=""></span>mg&#47;dL&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">HDL cholesterol<span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>40<span class="elsevierStyleHsp" style=""></span>mg&#47;dL &#40;&#9794;&#41; or<span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>50<span class="elsevierStyleHsp" style=""></span>mg&#47;dL &#40;&#9792;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
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            0 => array:3 [
              "identificador" => "tblfn0010"
              "etiqueta" => "a"
              "nota" => "<p class="elsevierStyleNotepara" id="npar0010">Source&#44; joint guidelines of the European Association for the Study of the Liver&#44; the European Association for the Study of Diabetes&#44; and the European Association for the Study of Obesity&#46;<a class="elsevierStyleCrossRef" href="#bib0385"><span class="elsevierStyleSup">17</span></a></p>"
            ]
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0050" class="elsevierStyleSimplePara elsevierViewall">Risk Factors for Metabolic Syndrome&#160;<a class="elsevierStyleCrossRef" href="#tblfn0010"><span class="elsevierStyleSup">a</span></a></p>"
        ]
      ]
      4 => array:5 [
        "identificador" => "tb0005"
        "tipo" => "MULTIMEDIATEXTO"
        "mostrarFloat" => false
        "mostrarDisplay" => true
        "texto" => array:1 [
          "textoCompleto" => "<span class="elsevierStyleSections"><span id="sec0045" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0065">Key Points</span><p id="par0135" class="elsevierStylePara elsevierViewall"><ul class="elsevierStyleList" id="lis0005"><li class="elsevierStyleListItem" id="lsti0005"><span class="elsevierStyleLabel">-</span><p id="par0140" class="elsevierStylePara elsevierViewall">The incidence of NAFLD is 1&#46;5- to 3-fold higher in psoriasis patients than in the nonpsoriatic population&#44; meaning we can expect to find NAFLD in roughly half of our patients with psoriasis&#46; The prevalence of steatohepatitis is also higher in psoriasis&#46;</p></li><li class="elsevierStyleListItem" id="lsti0010"><span class="elsevierStyleLabel">-</span><p id="par0145" class="elsevierStylePara elsevierViewall">Prognosis in NAFLD is affected by the presence and severity of steatohepatitis and liver fibrosis&#46;</p></li><li class="elsevierStyleListItem" id="lsti0015"><span class="elsevierStyleLabel">-</span><p id="par0150" class="elsevierStylePara elsevierViewall">Abdominal ultrasound screening is recommended in patients with insulin resistance or signs of metabolic syndrome and moderate to severe psoriasis&#44; even in the absence of abnormal liver enzymes&#46;</p></li><li class="elsevierStyleListItem" id="lsti0020"><span class="elsevierStyleLabel">-</span><p id="par0155" class="elsevierStylePara elsevierViewall">Patients with NAFLD should be referred to a specialist for evaluation and follow-up&#46;</p></li><li class="elsevierStyleListItem" id="lsti0025"><span class="elsevierStyleLabel">-</span><p id="par0160" class="elsevierStylePara elsevierViewall">A fatty liver limits therapeutic options and makes it advisable to tailor monitoring in patients taking potentially hepatotoxic drugs&#46;</p></li><li class="elsevierStyleListItem" id="lsti0030"><span class="elsevierStyleLabel">-</span><p id="par0165" class="elsevierStylePara elsevierViewall">Anti-TNF biologics offer theoretical benefits for patients with NAFLD as a result of better control of the inflammatory process and peripheral insulin resistance&#46; Ustekinumab and secukinumab do not seem to affect NAFLD adversely&#46;</p></li></ul></p></span></span>"
        ]
      ]
    ]
    "bibliografia" => array:2 [
      "titulo" => "References"
      "seccion" => array:1 [
        0 => array:2 [
          "identificador" => "bibs0005"
          "bibliografiaReferencia" => array:60 [
            0 => array:3 [
              "identificador" => "bib0305"
              "etiqueta" => "1"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The diagnosis and management of non-alcoholic fatty liver disease&#58; Practice guideline by the American Association for the Study of Liver Diseases&#44; American College of Gastroenterology&#44; and the American Gastroenterological Association"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "N&#46; Chalasani"
                            1 => "Z&#46; Younossi"
                            2 => "J&#46;E&#46; Lavine"
                            3 => "A&#46;M&#46; Diehl"
                            4 => "E&#46;M&#46; Brunt"
                            5 => "K&#46; Cusi"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1002/hep.25762"
                      "Revista" => array:6 [
                        "tituloSerie" => "Hepatology"
                        "fecha" => "2012"
                        "volumen" => "55"
                        "paginaInicial" => "2005"
                        "paginaFinal" => "2023"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/22488764"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            1 => array:3 [
              "identificador" => "bib0310"
              "etiqueta" => "2"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Nonalcoholic fatty liver disease&#58; A precursor of the metabolic syndrome"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "A&#46; Lonardo"
                            1 => "S&#46; Ballestri"
                            2 => "G&#46; Marchesini"
                            3 => "P&#46; Angulo"
                            4 => "P&#46; Loria"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.dld.2014.09.020"
                      "Revista" => array:6 [
                        "tituloSerie" => "Dig Liver Dis"
                        "fecha" => "2015"
                        "volumen" => "47"
                        "paginaInicial" => "181"
                        "paginaFinal" => "190"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/25739820"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            2 => array:3 [
              "identificador" => "bib0315"
              "etiqueta" => "3"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "NAFLD&#58; A multisystem disease"
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