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Some authors have stated that these patients have a later onset of the disease&#44; with a shorter duration of outbreaks&#44; milder symptoms&#44; and longer symptom-free intervals&#46;<a class="elsevierStyleCrossRef" href="#bib0065"><span class="elsevierStyleSup">3</span></a></p><p id="par0030" class="elsevierStylePara elsevierViewall">Gene <span class="elsevierStyleItalic">MEFV</span> codes the protein pyrin&#44; also known as marenostrin&#44; which plays a role in regulation of the innate immune response&#46; Alteration of this protein removes control from the pathway&#44; increasing the levels of interleukin 1&#946;&#44; responsible for the inflammatory response in this disease&#46;<a class="elsevierStyleCrossRef" href="#bib0070"><span class="elsevierStyleSup">4</span></a></p><p id="par0035" class="elsevierStylePara elsevierViewall">Soriano and Manna<a class="elsevierStyleCrossRef" href="#bib0075"><span class="elsevierStyleSup">5</span></a> described 4 clinical phenotypes of the disease&#58;<ul class="elsevierStyleList" id="lis0005"><li class="elsevierStyleListItem" id="lsti0005"><span class="elsevierStyleLabel">&#8211;</span><p id="par0040" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleItalic">Type 1&#58;</span> Patients with recurrent episodes of short duration &#40;12-72<span class="elsevierStyleHsp" style=""></span>h&#41; with fever&#44; acute abdominal pain&#44; joint involvement&#44; acute chest pain due to pleuritis&#47;pericarditis&#44; and various skin manifestations&#46; Patients are usually asymptomatic between outbreaks&#44; although biochemical evidence of the disease can be detected&#46;</p></li><li class="elsevierStyleListItem" id="lsti0010"><span class="elsevierStyleLabel">&#8211;</span><p id="par0045" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleItalic">Type 2&#58;</span> Patients who develop secondary amyloidosis &#40;AA type&#41; with proteinuria or kidney failure before they develop other signs of FMF&#44; or as the only manifestation in relatives of patients with FMF&#46;</p></li><li class="elsevierStyleListItem" id="lsti0015"><span class="elsevierStyleLabel">&#8211;</span><p id="par0050" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleItalic">Type 3&#58;</span> Carriers of a mutation of gene <span class="elsevierStyleItalic">MEFV</span> with no clinical manifestations of the disease and no amyloidosis&#46; This occurs in endemic populations &#40;such as Iraqi Jews and Ashkenazi Jews&#41;&#44; with a prevalence of 1 in 25 to 1 in 300 persons&#46; Although the majority never present clinical manifestations&#44; some do develop amyloidosis with time &#40;phenotype<span class="elsevierStyleHsp" style=""></span>2&#41;&#46;</p></li><li class="elsevierStyleListItem" id="lsti0020"><span class="elsevierStyleLabel">&#8211;</span><p id="par0055" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleItalic">FMF-like&#58;</span> Heterozygous patients with mild clinical manifestations of the disease&#46; Our patient falls into this phenotype&#46;</p></li></ul></p><p id="par0060" class="elsevierStylePara elsevierViewall">Cutaneous manifestations of the disease occur in 10&#37; to 40&#37; of affected patients&#46;<a class="elsevierStyleCrossRef" href="#bib0080"><span class="elsevierStyleSup">6</span></a> Only erysipelas- or cellulitis-like lesions&#44; seen in 5&#37; to 30&#37; of patients with FMF&#44; are considered specific&#44; and they arise on the anterior surface of the legs and dorsum of the feet&#46; Histology reveals a perivascular dermal infiltrate made up mainly of mononuclear cells and neutrophils&#44; but with no vasculitis&#46;<a class="elsevierStyleCrossRef" href="#bib0085"><span class="elsevierStyleSup">7</span></a> The episodes that affected our patient&#39;s legs probably corresponded to this clinical presentation&#46; Panniculitis can present as erythema nodosum or neutrophilic panniculitis&#46; Urticarial manifestations are more typical of other autoinflammatory syndromes&#44; such as TRAPS &#40;tumor necrosis factor receptor associated periodic fever syndrome&#41; and CAPS &#40;cryopyrin-associated autoinflammatory syndromes&#41;&#46;<a class="elsevierStyleCrossRef" href="#bib0090"><span class="elsevierStyleSup">8</span></a></p><p id="par0065" class="elsevierStylePara elsevierViewall">The differential diagnosis should include other autoinflammatory diseases&#46;<a class="elsevierStyleCrossRef" href="#bib0090"><span class="elsevierStyleSup">8</span></a> In our case&#44; we considered Muckle-Wells syndrome because of the urticarial lesions and neurosensorial deafness&#44; although the genetic analysis finally confirmed the diagnosis of FMF&#46; Some authors believe that patients with FMF may have a greater prevalence of auditory loss than the unaffected population&#44; but there has been no evidence of this in any controlled study&#46;<a class="elsevierStyleCrossRef" href="#bib0095"><span class="elsevierStyleSup">9</span></a></p><p id="par0070" class="elsevierStylePara elsevierViewall">The diagnostic criteria of FMF were established in 1997 &#40;Table<span class="elsevierStyleHsp" style=""></span>1&#41;&#46;<a class="elsevierStyleCrossRef" href="#bib0100"><span class="elsevierStyleSup">10</span></a> The diagnosis is clinical&#59; genetic analysis is only used for support&#46; In our opinion&#44; genetic analysis may be fundamental to reaching the diagnosis in some cases&#46; However&#44; detection of a mutation cannot alone confirm the diagnosis&#44; particularly in endemic populations in which prevalence of the mutation is very high&#46;</p><p id="par0075" class="elsevierStylePara elsevierViewall">The main objectives of treatment are the prevention of outbreaks and&#44; in the long-term&#44; of secondary amyloidosis&#46; The drug of choice is colchicine&#44; 1-3<span class="elsevierStyleHsp" style=""></span>mg&#47;d&#46;<a class="elsevierStyleCrossRef" href="#bib0070"><span class="elsevierStyleSup">4</span></a></p><p id="par0080" class="elsevierStylePara elsevierViewall">In conclusion&#44; in patients with recurrent episodes of fever with cutaneous manifestations&#44; we should consider the autoinflammatory syndromes&#44; which include FMF&#46; The diagnosis is basically clinical&#44; although genetic analysis can be very useful&#46; This disease is classically considered to have autosomal recessive inheritance&#44; although a notable percentage of heterozygous patients have symptoms&#44; meaning that aspects of the genetics of this disease still remain to be clarified&#46;</p></span>"
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        "nota" => "<p class="elsevierStyleNotepara" id="npar0020">Please cite this article as&#58; Pascual LL&#44; Garc&#237;a ML&#44; Ch&#225;varri CL&#44; Bayona JIY&#46; Fiebre mediterr&#225;nea familiar&#46; Dificultades diagn&#243;sticas en un caso at&#237;pico&#46; Actas Dermosifiliogr&#46; 2017&#59;108&#58;161&#8211;164&#46;</p>"
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          "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">A and B&#44; Large edematous erythematous plaques with an urticarial appearance and increased local temperature&#46; The lesions were found on the trunk and root of the upper limbs&#46;</p>"
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                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td-with-role" title="table-head ; entry_with_role_rowhead " align="left" valign="top" scope="col">Major Criteria&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col">Minor Criteria&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col">Data That Support the Diagnosis&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Typical episodes&#58; recurrent&#44; &#60;72<span class="elsevierStyleHsp" style=""></span>hours&#44; febrile<br><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>1&#46; Diffuse peritonitis<br><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>2&#46; Unilateral pleuritis or pericarditis<br><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>3&#46; Monoarthritis of the lower limbs<br><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>4&#46; Fever as the only manifestation&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleBold">Atypical episodes</span><a class="elsevierStyleCrossRef" href="#tblfn0010"><span class="elsevierStyleSup">b</span></a>&#58; no fever&#44; longer duration&#44; other manifestations different from 1-3 of the Major Criteria<br>4&#46; Pain in the lower limbs on exertion<br>5&#46; <span class="elsevierStyleBold">Favorable response to colchicine</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">1&#46; Family history of FMF<br>2&#46; Typical ethnic origin<br>3&#46; Onset<span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>20 years<br>Characteristics of the episodes&#58;<br>4&#46; <span class="elsevierStyleBold">Marked alteration of the general state&#44; requiring rest</span><br>5&#46; <span class="elsevierStyleBold">Spontaneous remission</span><br>6&#46; <span class="elsevierStyleBold">Symptom-free between episodes</span><br>7&#46; Elevation of at least 1 AFR&#58; fibrinogen&#44; white cell count&#44; ESR<br>8&#46; Episodes of proteinuria or hematuria<br>9&#46; Acute abdomen with negative exploratory laparotomy<br>10&#46; Consanguinity&nbsp;\t\t\t\t\t\t\n
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              "nota" => "<p class="elsevierStyleNotepara" id="npar0010">The criteria in our patient&#44; who satisfied 2 minor criteria and 4 findings that supported the diagnosis&#44; are shown in bold type&#46;</p> <p class="elsevierStyleNotepara" id="npar0015">AFR indicates acute phase reactant&#59; ESR&#44; erythrocyte sedimentation rate&#46;</p>"
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Case and Research Letter
Familial Mediterranean Fever: Diagnostic Difficulties in an Atypical Case
Fiebre mediterránea familiar. Dificultades diagnósticas en un caso atípico
L. Loidi Pascuala,
Autor para correspondencia
, M. Larrea Garcíaa, C. Llanos Chávarrib, J.I. Yanguas Bayonaa
a Servicio de Dermatología, Complejo Hospitalario de Navarra, Pamplona, Navarra, Spain
b Servicio de Anatomía Patológica, Complejo Hospitalario de Navarra, Pamplona, Navarra, Spain
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with blisters and an abundant exudate &#40;<a class="elsevierStyleCrossRef" href="#fig0015">Fig&#46; 3</a>&#41;&#46; A gram-negative microorganism was isolated on culture&#44; and this was interpreted as infectious cellulitis&#46; Four months later she presented similar manifestations in her other leg&#46;</p><elsevierMultimedia ident="fig0015"></elsevierMultimedia><p id="par0015" class="elsevierStylePara elsevierViewall">Genetic analysis was performed of genes <span class="elsevierStyleItalic">MEFV</span>&#44; <span class="elsevierStyleItalic">TNFRSF1A</span>&#44; <span class="elsevierStyleItalic">MVK</span>&#44; <span class="elsevierStyleItalic">NLRP3</span>&#44; <span class="elsevierStyleItalic">NOD2</span>&#44; and <span class="elsevierStyleItalic">PSTPIP1</span>&#46; The patient was heterozygous for the c&#46;1772T&#62;C variant of gene <span class="elsevierStyleItalic">MEFV</span>&#46;</p><p id="par0020" class="elsevierStylePara elsevierViewall">As she also satisfied the Tel-Hashomer diagnostic criteria for familial Mediterranean fever &#40;FMF&#41; &#40;<a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a>&#41;&#44; she was diagnosed with this entity&#46; Treatment was started with colchicine&#44; which led to a marked improvement in the clinical manifestations&#46;</p><elsevierMultimedia ident="tbl0005"></elsevierMultimedia><p id="par0025" class="elsevierStylePara elsevierViewall">FMF is the most common autoinflammatory disease of adults&#46;<a class="elsevierStyleCrossRef" href="#bib0055"><span class="elsevierStyleSup">1</span></a> It has a monogenic autosomal recessive inheritance&#44; caused by a mutation in gene <span class="elsevierStyleItalic">MEFV</span> &#40;16p13&#46;3&#41;&#44; although 20&#37; of patients are heterozygous&#46;<a class="elsevierStyleCrossRef" href="#bib0060"><span class="elsevierStyleSup">2</span></a> This could be because it is actually an autosomal dominant disease with variable penetrance&#44; it was not possible to detect the second mutation due to technical limitations&#44; or that it could be a polygenic disease&#46; Some authors have stated that these patients have a later onset of the disease&#44; with a shorter duration of outbreaks&#44; milder symptoms&#44; and longer symptom-free intervals&#46;<a class="elsevierStyleCrossRef" href="#bib0065"><span class="elsevierStyleSup">3</span></a></p><p id="par0030" class="elsevierStylePara elsevierViewall">Gene <span class="elsevierStyleItalic">MEFV</span> codes the protein pyrin&#44; also known as marenostrin&#44; which plays a role in regulation of the innate immune response&#46; Alteration of this protein removes control from the pathway&#44; increasing the levels of interleukin 1&#946;&#44; responsible for the inflammatory response in this disease&#46;<a class="elsevierStyleCrossRef" href="#bib0070"><span class="elsevierStyleSup">4</span></a></p><p id="par0035" class="elsevierStylePara elsevierViewall">Soriano and Manna<a class="elsevierStyleCrossRef" href="#bib0075"><span class="elsevierStyleSup">5</span></a> described 4 clinical phenotypes of the disease&#58;<ul class="elsevierStyleList" id="lis0005"><li class="elsevierStyleListItem" id="lsti0005"><span class="elsevierStyleLabel">&#8211;</span><p id="par0040" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleItalic">Type 1&#58;</span> Patients with recurrent episodes of short duration &#40;12-72<span class="elsevierStyleHsp" style=""></span>h&#41; with fever&#44; acute abdominal pain&#44; joint involvement&#44; acute chest pain due to pleuritis&#47;pericarditis&#44; and various skin manifestations&#46; Patients are usually asymptomatic between outbreaks&#44; although biochemical evidence of the disease can be detected&#46;</p></li><li class="elsevierStyleListItem" id="lsti0010"><span class="elsevierStyleLabel">&#8211;</span><p id="par0045" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleItalic">Type 2&#58;</span> Patients who develop secondary amyloidosis &#40;AA type&#41; with proteinuria or kidney failure before they develop other signs of FMF&#44; or as the only manifestation in relatives of patients with FMF&#46;</p></li><li class="elsevierStyleListItem" id="lsti0015"><span class="elsevierStyleLabel">&#8211;</span><p id="par0050" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleItalic">Type 3&#58;</span> Carriers of a mutation of gene <span class="elsevierStyleItalic">MEFV</span> with no clinical manifestations of the disease and no amyloidosis&#46; This occurs in endemic populations &#40;such as Iraqi Jews and Ashkenazi Jews&#41;&#44; with a prevalence of 1 in 25 to 1 in 300 persons&#46; Although the majority never present clinical manifestations&#44; some do develop amyloidosis with time &#40;phenotype<span class="elsevierStyleHsp" style=""></span>2&#41;&#46;</p></li><li class="elsevierStyleListItem" id="lsti0020"><span class="elsevierStyleLabel">&#8211;</span><p id="par0055" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleItalic">FMF-like&#58;</span> Heterozygous patients with mild clinical manifestations of the disease&#46; Our patient falls into this phenotype&#46;</p></li></ul></p><p id="par0060" class="elsevierStylePara elsevierViewall">Cutaneous manifestations of the disease occur in 10&#37; to 40&#37; of affected patients&#46;<a class="elsevierStyleCrossRef" href="#bib0080"><span class="elsevierStyleSup">6</span></a> Only erysipelas- or cellulitis-like lesions&#44; seen in 5&#37; to 30&#37; of patients with FMF&#44; are considered specific&#44; and they arise on the anterior surface of the legs and dorsum of the feet&#46; Histology reveals a perivascular dermal infiltrate made up mainly of mononuclear cells and neutrophils&#44; but with no vasculitis&#46;<a class="elsevierStyleCrossRef" href="#bib0085"><span class="elsevierStyleSup">7</span></a> The episodes that affected our patient&#39;s legs probably corresponded to this clinical presentation&#46; Panniculitis can present as erythema nodosum or neutrophilic panniculitis&#46; Urticarial manifestations are more typical of other autoinflammatory syndromes&#44; such as TRAPS &#40;tumor necrosis factor receptor associated periodic fever syndrome&#41; and CAPS &#40;cryopyrin-associated autoinflammatory syndromes&#41;&#46;<a class="elsevierStyleCrossRef" href="#bib0090"><span class="elsevierStyleSup">8</span></a></p><p id="par0065" class="elsevierStylePara elsevierViewall">The differential diagnosis should include other autoinflammatory diseases&#46;<a class="elsevierStyleCrossRef" href="#bib0090"><span class="elsevierStyleSup">8</span></a> In our case&#44; we considered Muckle-Wells syndrome because of the urticarial lesions and neurosensorial deafness&#44; although the genetic analysis finally confirmed the diagnosis of FMF&#46; Some authors believe that patients with FMF may have a greater prevalence of auditory loss than the unaffected population&#44; but there has been no evidence of this in any controlled study&#46;<a class="elsevierStyleCrossRef" href="#bib0095"><span class="elsevierStyleSup">9</span></a></p><p id="par0070" class="elsevierStylePara elsevierViewall">The diagnostic criteria of FMF were established in 1997 &#40;Table<span class="elsevierStyleHsp" style=""></span>1&#41;&#46;<a class="elsevierStyleCrossRef" href="#bib0100"><span class="elsevierStyleSup">10</span></a> The diagnosis is clinical&#59; genetic analysis is only used for support&#46; In our opinion&#44; genetic analysis may be fundamental to reaching the diagnosis in some cases&#46; However&#44; detection of a mutation cannot alone confirm the diagnosis&#44; particularly in endemic populations in which prevalence of the mutation is very high&#46;</p><p id="par0075" class="elsevierStylePara elsevierViewall">The main objectives of treatment are the prevention of outbreaks and&#44; in the long-term&#44; of secondary amyloidosis&#46; The drug of choice is colchicine&#44; 1-3<span class="elsevierStyleHsp" style=""></span>mg&#47;d&#46;<a class="elsevierStyleCrossRef" href="#bib0070"><span class="elsevierStyleSup">4</span></a></p><p id="par0080" class="elsevierStylePara elsevierViewall">In conclusion&#44; in patients with recurrent episodes of fever with cutaneous manifestations&#44; we should consider the autoinflammatory syndromes&#44; which include FMF&#46; The diagnosis is basically clinical&#44; although genetic analysis can be very useful&#46; This disease is classically considered to have autosomal recessive inheritance&#44; although a notable percentage of heterozygous patients have symptoms&#44; meaning that aspects of the genetics of this disease still remain to be clarified&#46;</p></span>"
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        "nota" => "<p class="elsevierStyleNotepara" id="npar0020">Please cite this article as&#58; Pascual LL&#44; Garc&#237;a ML&#44; Ch&#225;varri CL&#44; Bayona JIY&#46; Fiebre mediterr&#225;nea familiar&#46; Dificultades diagn&#243;sticas en un caso at&#237;pico&#46; Actas Dermosifiliogr&#46; 2017&#59;108&#58;161&#8211;164&#46;</p>"
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          "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">A and B&#44; Large edematous erythematous plaques with an urticarial appearance and increased local temperature&#46; The lesions were found on the trunk and root of the upper limbs&#46;</p>"
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          "en" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Edema associated with a moderate inflammatory infiltrate of lymphocytes and neutrophils in the superficial dermis&#44; with occasional images of leukocytoclasia&#46; No extravasation of red blood cells is observed&#44; nor the presence of hemosiderophages or lesions of fibrinoid necrosis in the vessel walls&#46; Hematoxylin and eosin&#44; original magnification<span class="elsevierStyleHsp" style=""></span>&#215;20&#46;</p>"
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                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td-with-role" title="table-head ; entry_with_role_rowhead " align="left" valign="top" scope="col">Major Criteria&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col">Minor Criteria&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col">Data That Support the Diagnosis&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Typical episodes&#58; recurrent&#44; &#60;72<span class="elsevierStyleHsp" style=""></span>hours&#44; febrile<br><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>1&#46; Diffuse peritonitis<br><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>2&#46; Unilateral pleuritis or pericarditis<br><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>3&#46; Monoarthritis of the lower limbs<br><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>4&#46; Fever as the only manifestation&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleBold">Atypical episodes</span><a class="elsevierStyleCrossRef" href="#tblfn0010"><span class="elsevierStyleSup">b</span></a>&#58; no fever&#44; longer duration&#44; other manifestations different from 1-3 of the Major Criteria<br>4&#46; Pain in the lower limbs on exertion<br>5&#46; <span class="elsevierStyleBold">Favorable response to colchicine</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">1&#46; Family history of FMF<br>2&#46; Typical ethnic origin<br>3&#46; Onset<span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>20 years<br>Characteristics of the episodes&#58;<br>4&#46; <span class="elsevierStyleBold">Marked alteration of the general state&#44; requiring rest</span><br>5&#46; <span class="elsevierStyleBold">Spontaneous remission</span><br>6&#46; <span class="elsevierStyleBold">Symptom-free between episodes</span><br>7&#46; Elevation of at least 1 AFR&#58; fibrinogen&#44; white cell count&#44; ESR<br>8&#46; Episodes of proteinuria or hematuria<br>9&#46; Acute abdomen with negative exploratory laparotomy<br>10&#46; Consanguinity&nbsp;\t\t\t\t\t\t\n
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              "nota" => "<p class="elsevierStyleNotepara" id="npar0010">The criteria in our patient&#44; who satisfied 2 minor criteria and 4 findings that supported the diagnosis&#44; are shown in bold type&#46;</p> <p class="elsevierStyleNotepara" id="npar0015">AFR indicates acute phase reactant&#59; ESR&#44; erythrocyte sedimentation rate&#46;</p>"
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          "en" => "<p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">Tel-Hashomer Diagnostic Criteria<a class="elsevierStyleCrossRef" href="#tblfn0005"><span class="elsevierStyleSup">a</span></a></p>"
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