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1</a>&#41;&#46; Dermoscopic examination showed polymorphous &#40;dotted and hairpin&#41; vessels surrounded by a whitish halo in the vascularized component and brown pigment with peripheral projections that did not radiate from the center of the lesion or form a specific dermoscopic pattern in the pigmented component &#40;<a class="elsevierStyleCrossRef" href="#fig0010">Fig&#46; 2</a>&#41;&#46; An excisional biopsy was performed to check for melanoma and pigmented basal cell carcinoma &#40;BCC&#41;&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><elsevierMultimedia ident="fig0010"></elsevierMultimedia></span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0015">Histopathology</span><p id="par0015" class="elsevierStylePara elsevierViewall">Histologic examination showed hyperkeratosis with parakeratosis&#44; fibrin&#44; and foci of melanin pigment on the surface&#46; There were thick&#44; well-delimited ridges in the Malpighian layer&#44; with no invasion of the underlying dermis&#46; Differentiated keratinocytes&#44; anisocytosis&#44; anisokaryosis&#44; and large hyperchromatic nuclei were observed throughout this layer&#46; There were also horn pearls and hyperpigmentation of keratinocytes without associated melanocytic hyperplasia in the pigmented component&#46; Additional findings included a moderate band-like lymphohistiocytic infiltrate with abundant melanophages in the underlying dermis&#44; under the lesional epithelium &#40;<a class="elsevierStyleCrossRef" href="#fig0015">Fig&#46; 3</a>&#41;&#46;</p><elsevierMultimedia ident="fig0015"></elsevierMultimedia><p id="par0020" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleBold">What Is Your Diagnosis&#63;</span></p></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0020">Diagnosis</span><p id="par0025" class="elsevierStylePara elsevierViewall">Pigmented squamous cell carcinoma in situ in a component of a lesion&#46;</p></span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0025">Clinical Course and Treatment</span><p id="par0030" class="elsevierStylePara elsevierViewall">We widened the tumor margins and found no residual tumor in the specimen analyzed&#46; In 2 years of follow-up&#44; there have been no signs of recurrence or new lesions&#46;</p></span><span id="sec0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0030">Comments</span><p id="par0035" class="elsevierStylePara elsevierViewall">SSC is the second most common malignant skin tumor&#44; but the pigmented variant of this tumor is rare&#44; accounting for just 7&#37; to 25&#37; of all SCCs&#46;<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">1</span></a></p><p id="par0040" class="elsevierStylePara elsevierViewall">Pigmented SCC typically presents as pigmented papules or plaques in sun-exposed areas of the head and neck in elderly individuals&#46;<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">1</span></a> Our case is interesting not just because the lesion was pigmented&#44; but also because it involved a patient under 70 years of age and was located in a part of the body that had not been damaged by the sun&#46;<a class="elsevierStyleCrossRef" href="#bib0040"><span class="elsevierStyleSup">2</span></a> Dermoscopic features of pigmented SCC include a scaling surface&#44; diffuse or homogeneous blue pigmentation and&#47;or irregularly distributed granular structures&#59; the vessels are often not visible because of the pigment&#46;<a class="elsevierStyleCrossRef" href="#bib0045"><span class="elsevierStyleSup">3</span></a> Vascular structures can be highly polymorphous&#44; with irregular hairpin vessels&#44; dotted and&#47;or irregular linear vessels&#44; and spiral vessels&#44; surrounded on occasions by a whitish halo&#46; Chung et al&#46;<a class="elsevierStyleCrossRef" href="#bib0050"><span class="elsevierStyleSup">4</span></a> recently published a case of SCC in situ with&#44; as in our case&#44; pigmented projections in peripheral sectors that did not converge geometrically towards the center of the lesion&#46; The authors proposed that this finding suggests a possible nonmelanocytic origin&#44; and together with the scaling&#44; a probable diagnosis of SCC&#46; The presence of whitish perivascular halos suggests a high degree of differentiation&#44;<a class="elsevierStyleCrossRef" href="#bib0055"><span class="elsevierStyleSup">5</span></a> which was observed in our case&#46;</p><p id="par0045" class="elsevierStylePara elsevierViewall">The pathophysiology of pigmented SCC is uncertain&#44; and it is thought that the tumor cells might produce cytokines and growth factors that favor melanocytic proliferation and colonization&#46; Another possibility is that the tumor originates from stem cells&#46;<a class="elsevierStyleCrossRef" href="#bib0060"><span class="elsevierStyleSup">6</span></a></p><p id="par0050" class="elsevierStylePara elsevierViewall">Histology shows typical features of conventional SCC in addition to pigment in the cytoplasm of the keratinocytes or throughout the tumor in the form of dispersed nonneoplastic dendritic melanocytes and melanophages in the surrounding stroma&#46;<a class="elsevierStyleCrossRef" href="#bib0040"><span class="elsevierStyleSup">2</span></a></p><p id="par0055" class="elsevierStylePara elsevierViewall">The differential diagnosis should include pigmented actinic keratosis&#44; pigmented Bowen disease&#44; seborrheic keratosis&#44; pigmented basal cell carcinoma&#44; melanoma&#44; and other adnexal tumors &#40;trichoblastoma and pilomatricoma&#41;&#46;<a class="elsevierStyleCrossRef" href="#bib0060"><span class="elsevierStyleSup">6</span></a></p><p id="par0060" class="elsevierStylePara elsevierViewall">As there have been few reports of pigmented SCC&#44; little is known about the biologic behavior of this tumor&#46; While pigmentation does not have any prognostic value&#44; it can prompt early consultation&#46;<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">1</span></a></p><p id="par0065" class="elsevierStylePara elsevierViewall">In conclusion&#44; although an atypical pigmented lesion in an area of the body protected from the sun may typically suggest melanoma&#44; pigmented BCC&#44; or seborrheic keratosis&#44; the presence of scaling&#44; nongeometric pigmented projections&#44; and a whitish perivascular halo should raise suspicion of BCC&#46;</p></span><span id="sec0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0035">Conflicts of Interest</span><p id="par0070" class="elsevierStylePara elsevierViewall">The authors declare that they have no conflicts of interest&#46;</p></span></span>"
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Cases for Diagnosis
Pigmented Vascular Tumor in Skin Not Exposed to Sunlight
Lesión tumoral pigmentada y vascular en piel no fotoexpuesta
C. Guebenlian
Autor para correspondencia
, J. Magliano, C. Agorio
Cátedra de Dermatología Médico Quirúrgica, Hospital de Clínicas «Dr. Manuel Quintela», Universidad de la República, Montevideo, Uruguay
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    "textoCompleto" => "<span class="elsevierStyleSections"><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0005">Medical History</span><p id="par0005" class="elsevierStylePara elsevierViewall">A 68-year-old hypertensive woman consulted about an asymptomatic lesion of 1 year&#39;s duration at her annual checkup&#46; Her last check up had been 2 years earlier&#44; and there had been no remarkable findings&#46;</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0010">Physical Examination</span><p id="par0010" class="elsevierStylePara elsevierViewall">The physical examination revealed a slightly indurated tumor measuring 2<span class="elsevierStyleHsp" style=""></span>cm on the left buttock&#46; The lesion had 2 components&#58; a pink erythematous component with a vascular appearance and a white-yellowish scale-crust&#44; and a second component with brown pigmentation &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>&#41;&#46; Dermoscopic examination showed polymorphous &#40;dotted and hairpin&#41; vessels surrounded by a whitish halo in the vascularized component and brown pigment with peripheral projections that did not radiate from the center of the lesion or form a specific dermoscopic pattern in the pigmented component &#40;<a class="elsevierStyleCrossRef" href="#fig0010">Fig&#46; 2</a>&#41;&#46; An excisional biopsy was performed to check for melanoma and pigmented basal cell carcinoma &#40;BCC&#41;&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><elsevierMultimedia ident="fig0010"></elsevierMultimedia></span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0015">Histopathology</span><p id="par0015" class="elsevierStylePara elsevierViewall">Histologic examination showed hyperkeratosis with parakeratosis&#44; fibrin&#44; and foci of melanin pigment on the surface&#46; There were thick&#44; well-delimited ridges in the Malpighian layer&#44; with no invasion of the underlying dermis&#46; Differentiated keratinocytes&#44; anisocytosis&#44; anisokaryosis&#44; and large hyperchromatic nuclei were observed throughout this layer&#46; There were also horn pearls and hyperpigmentation of keratinocytes without associated melanocytic hyperplasia in the pigmented component&#46; Additional findings included a moderate band-like lymphohistiocytic infiltrate with abundant melanophages in the underlying dermis&#44; under the lesional epithelium &#40;<a class="elsevierStyleCrossRef" href="#fig0015">Fig&#46; 3</a>&#41;&#46;</p><elsevierMultimedia ident="fig0015"></elsevierMultimedia><p id="par0020" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleBold">What Is Your Diagnosis&#63;</span></p></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0020">Diagnosis</span><p id="par0025" class="elsevierStylePara elsevierViewall">Pigmented squamous cell carcinoma in situ in a component of a lesion&#46;</p></span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0025">Clinical Course and Treatment</span><p id="par0030" class="elsevierStylePara elsevierViewall">We widened the tumor margins and found no residual tumor in the specimen analyzed&#46; In 2 years of follow-up&#44; there have been no signs of recurrence or new lesions&#46;</p></span><span id="sec0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0030">Comments</span><p id="par0035" class="elsevierStylePara elsevierViewall">SSC is the second most common malignant skin tumor&#44; but the pigmented variant of this tumor is rare&#44; accounting for just 7&#37; to 25&#37; of all SCCs&#46;<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">1</span></a></p><p id="par0040" class="elsevierStylePara elsevierViewall">Pigmented SCC typically presents as pigmented papules or plaques in sun-exposed areas of the head and neck in elderly individuals&#46;<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">1</span></a> Our case is interesting not just because the lesion was pigmented&#44; but also because it involved a patient under 70 years of age and was located in a part of the body that had not been damaged by the sun&#46;<a class="elsevierStyleCrossRef" href="#bib0040"><span class="elsevierStyleSup">2</span></a> Dermoscopic features of pigmented SCC include a scaling surface&#44; diffuse or homogeneous blue pigmentation and&#47;or irregularly distributed granular structures&#59; the vessels are often not visible because of the pigment&#46;<a class="elsevierStyleCrossRef" href="#bib0045"><span class="elsevierStyleSup">3</span></a> Vascular structures can be highly polymorphous&#44; with irregular hairpin vessels&#44; dotted and&#47;or irregular linear vessels&#44; and spiral vessels&#44; surrounded on occasions by a whitish halo&#46; Chung et al&#46;<a class="elsevierStyleCrossRef" href="#bib0050"><span class="elsevierStyleSup">4</span></a> recently published a case of SCC in situ with&#44; as in our case&#44; pigmented projections in peripheral sectors that did not converge geometrically towards the center of the lesion&#46; The authors proposed that this finding suggests a possible nonmelanocytic origin&#44; and together with the scaling&#44; a probable diagnosis of SCC&#46; The presence of whitish perivascular halos suggests a high degree of differentiation&#44;<a class="elsevierStyleCrossRef" href="#bib0055"><span class="elsevierStyleSup">5</span></a> which was observed in our case&#46;</p><p id="par0045" class="elsevierStylePara elsevierViewall">The pathophysiology of pigmented SCC is uncertain&#44; and it is thought that the tumor cells might produce cytokines and growth factors that favor melanocytic proliferation and colonization&#46; Another possibility is that the tumor originates from stem cells&#46;<a class="elsevierStyleCrossRef" href="#bib0060"><span class="elsevierStyleSup">6</span></a></p><p id="par0050" class="elsevierStylePara elsevierViewall">Histology shows typical features of conventional SCC in addition to pigment in the cytoplasm of the keratinocytes or throughout the tumor in the form of dispersed nonneoplastic dendritic melanocytes and melanophages in the surrounding stroma&#46;<a class="elsevierStyleCrossRef" href="#bib0040"><span class="elsevierStyleSup">2</span></a></p><p id="par0055" class="elsevierStylePara elsevierViewall">The differential diagnosis should include pigmented actinic keratosis&#44; pigmented Bowen disease&#44; seborrheic keratosis&#44; pigmented basal cell carcinoma&#44; melanoma&#44; and other adnexal tumors &#40;trichoblastoma and pilomatricoma&#41;&#46;<a class="elsevierStyleCrossRef" href="#bib0060"><span class="elsevierStyleSup">6</span></a></p><p id="par0060" class="elsevierStylePara elsevierViewall">As there have been few reports of pigmented SCC&#44; little is known about the biologic behavior of this tumor&#46; While pigmentation does not have any prognostic value&#44; it can prompt early consultation&#46;<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">1</span></a></p><p id="par0065" class="elsevierStylePara elsevierViewall">In conclusion&#44; although an atypical pigmented lesion in an area of the body protected from the sun may typically suggest melanoma&#44; pigmented BCC&#44; or seborrheic keratosis&#44; the presence of scaling&#44; nongeometric pigmented projections&#44; and a whitish perivascular halo should raise suspicion of BCC&#46;</p></span><span id="sec0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0035">Conflicts of Interest</span><p id="par0070" class="elsevierStylePara elsevierViewall">The authors declare that they have no conflicts of interest&#46;</p></span></span>"
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2023 Noviembre 66 34 100
2023 Octubre 71 22 93
2023 Septiembre 87 25 112
2023 Agosto 65 17 82
2023 Julio 65 33 98
2023 Junio 47 24 71
2023 Mayo 44 33 77
2023 Abril 42 17 59
2023 Marzo 57 15 72
2023 Febrero 46 19 65
2023 Enero 51 27 78
2022 Diciembre 43 30 73
2022 Noviembre 28 20 48
2022 Octubre 26 17 43
2022 Septiembre 38 34 72
2022 Agosto 27 33 60
2022 Julio 36 35 71
2022 Junio 19 18 37
2022 Mayo 52 38 90
2022 Abril 41 24 65
2022 Marzo 61 43 104
2022 Febrero 35 19 54
2022 Enero 60 31 91
2021 Diciembre 33 39 72
2021 Noviembre 45 37 82
2021 Octubre 35 42 77
2021 Septiembre 33 38 71
2021 Agosto 32 26 58
2021 Julio 26 25 51
2021 Junio 30 28 58
2021 Mayo 33 38 71
2021 Abril 70 24 94
2021 Marzo 48 18 66
2021 Febrero 51 27 78
2021 Enero 35 13 48
2020 Diciembre 27 11 38
2020 Noviembre 41 24 65
2020 Octubre 31 15 46
2020 Septiembre 28 7 35
2020 Agosto 26 14 40
2020 Julio 21 16 37
2020 Junio 40 31 71
2020 Mayo 28 15 43
2020 Abril 24 18 42
2020 Marzo 32 17 49
2020 Febrero 3 0 3
2019 Diciembre 4 0 4
2019 Septiembre 4 0 4
2019 Junio 2 0 2
2019 Abril 4 1 5
2019 Marzo 2 3 5
2019 Enero 1 0 1
2018 Diciembre 1 0 1
2018 Noviembre 11 0 11
2018 Octubre 61 0 61
2018 Septiembre 6 0 6
2018 Febrero 18 4 22
2018 Enero 26 5 31
2017 Diciembre 41 10 51
2017 Noviembre 23 6 29
2017 Octubre 25 5 30
2017 Septiembre 24 10 34
2017 Agosto 20 4 24
2017 Julio 25 6 31
2017 Junio 29 7 36
2017 Mayo 30 5 35
2017 Abril 32 2 34
2017 Marzo 10 4 14
2017 Febrero 11 6 17
2017 Enero 10 4 14
2016 Diciembre 18 11 29
2016 Noviembre 27 8 35
2016 Octubre 23 19 42
2016 Agosto 1 0 1
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