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"apellidos" => "Solorzano-Mariscal" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">c</span>" "identificador" => "aff0015" ] ] ] ] "afiliaciones" => array:3 [ 0 => array:3 [ "entidad" => "Unidad de Gestión Clínica de CMA-Dermatología Médico Quirúrgica y Venereología, Complejo Hospitalario de Jaén, Jaén, Spain" "etiqueta" => "a" "identificador" => "aff0005" ] 1 => array:3 [ "entidad" => "Unidad de Gestión Clínica de Dermatología Médico Quirúrgica y Venereología, Hospital Universitario Virgen de las Nieves, Granada, Spain" "etiqueta" => "b" "identificador" => "aff0010" ] 2 => array:3 [ "entidad" => "Servicio de Anatomía Patológica, Complejo Hospitalario de Jaén, Jaén, Spain" "etiqueta" => "c" "identificador" => "aff0015" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "⁎" "correspondencia" => "Corresponding author." ] ] ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Pitiriasis liquenoide crónica inducida por adalimumab en paciente con psoriasis y buena respuesta a metotrexato" ] ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0010" "etiqueta" => "Figure 2" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr2.jpeg" "Alto" => 749 "Ancho" => 995 "Tamanyo" => 313181 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Psoriasiform acanthosis with parakeratosis and mild superficial lymphohistiocytic inflammatory infiltrate with extravasation of some red blood cells. Focal vacuolar changes in basal keratinocytes (original magnification, hematoxylin-eosin ×<span class="elsevierStyleHsp" style=""></span>100).</p>" ] ] ] "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">Biologic therapy is widely used in the treatment of psoriasis, and the incidence of adverse cutaneous effects induced by tumor necrosis factor (TNF) α antagonists is increasing.<a class="elsevierStyleCrossRef" href="#bib0060"><span class="elsevierStyleSup">1</span></a> A wide range of skin lesions, with variable morphologic features and causes, have been reported in addition to injection site reactions and skin infections. Of particular note is the increasing number of reports of immune-mediated paradoxical reactions, such as psoriasis and psoriasis-like rashes.<a class="elsevierStyleCrossRef" href="#bib0065"><span class="elsevierStyleSup">2</span></a> Only 5 cases of lichenoid reactions associated with TNF-α antagonists, however, have been reported to date.</p><p id="par0010" class="elsevierStylePara elsevierViewall">We present the case of a 45-year-old hypertensive, diabetic man, with no known allergies, who had a history of unstable moderate to severe plaque psoriasis of 20 years’ duration associated with psoriatic arthritis of 3 years’ duration. The patient had been treated with topical drugs (various), systemic therapy (oral acitretin), and subsequently, biologic therapy (etanercept—interrupted at 15 months due to a loss of effectiveness—and ustekinumab—interrupted at 9 months due to lack of indication for use in psoriatic arthritis at the time of diagnosis). The patient, with a Psoriasis Area and Severity Index (PASI) score of 12 and a body surface area score of 18, eventually continued treatment with adalimumab 40<span class="elsevierStyleHsp" style=""></span>mg, and achieved PASI 0 at 8 weeks, with resolution of joint pain. Shortly afterwards, he reported the appearance of an intermittent rash consisting of small asymptomatic lesions that did not coincide with the presence of infections or fever or the use of other medications. The rashes had been believed to be outbreaks of guttate psoriasis for a period of 8 months, and did not resolve on interruption of adalimumab therapy. Examination revealed multiple, small, firm scaling erythematous papules that covered large areas of the trunk and the proximal extremities, with sparing of the palms, soles, and mucous membranes. The lesions were at different stages of development; some were residual pigmented lesions, while others had a lichenoid appearance with thin, superficial micaceous scales (<a class="elsevierStyleCrossRef" href="#fig0005">Fig. 1</a>). The diagnosis was revisited, and laboratory tests, including complete blood count, biochemistry, serology, antistreptolysin O, and antinuclear antibodies, were ordered. All the results were negative or within normal ranges. Skin biopsy showed psoriasiform acanthosis with minimal parakeratosis, a discrete perivascular lymphohistiocytic inflammatory infiltrate and extravasated red blood cells, and isolated vacuolar changes in the basal layer, in addition to minimal epidermal lymphocytic exocytosis and isolated necrotic keratinocytes (<a class="elsevierStyleCrossRef" href="#fig0010">Fig. 2</a>). These findings were consistent with a diagnosis of pityriasis lichenoides chronica (PLC). It was decided to add methotrexate 15<span class="elsevierStyleHsp" style=""></span>mg weekly to the existing treatment with adalimumab. The rash resolved at 6 weeks, and the methotrexate dose was subsequently reduced, and the treatment withdrawn at 10 weeks. Three months later, the patient reported new lesions, which were again brought under control with methotrexate. After 6 months of follow-up, the patient remains asymptomatic (<a class="elsevierStyleCrossRef" href="#fig0015">Fig. 3</a>).</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><elsevierMultimedia ident="fig0010"></elsevierMultimedia><elsevierMultimedia ident="fig0015"></elsevierMultimedia><p id="par0015" class="elsevierStylePara elsevierViewall">Many adverse skin reactions have been reported in association with TNF-α antagonists.<a class="elsevierStyleCrossRef" href="#bib0070"><span class="elsevierStyleSup">3</span></a> In a recent publication, Newell et al.<a class="elsevierStyleCrossRef" href="#bib0075"><span class="elsevierStyleSup">4</span></a> reported the development of PLC in a patient with psoriasis after the third infusion of infliximab, and in a later study, Said et al.<a class="elsevierStyleCrossRef" href="#bib0080"><span class="elsevierStyleSup">5</span></a> published 2 cases of PLC in patients with Crohn disease under treatment with adalimumab. In both cases, complete remission was achieved following the addition of methotrexate. López-Ferrer et al.<a class="elsevierStyleCrossRef" href="#bib0085"><span class="elsevierStyleSup">6</span></a> also described a case of PLC after the use of infliximab in a patient with ankylosing spondylitis and ulcerative colitis. A favorable response was also observed when methotrexate was added. Finally, Echeverri et al.<a class="elsevierStyleCrossRef" href="#bib0090"><span class="elsevierStyleSup">7</span></a> published a case of PLC that appeared during week 6 of etanercept therapy in a patient with rheumatoid arthritis. The condition improved with the use of topical corticosteroids. Our case is the sixth report in the literature of PLC induced by a TNF-α antagonist and the first of good response to methotrexate in a patient with psoriasis being treated with adalimumab. Although we cannot rule out spontaneous resolution, our experience is similar to that reported by Said et al. and López-Ferrer et al. What causes pityriasis lichenoid and its variants remains unknown,<a class="elsevierStyleCrossRef" href="#bib0095"><span class="elsevierStyleSup">8</span></a> but TNF-α appears to have a role, as increased serum levels of this cytokine have been reported in a patient with febrile ulceronecrotic Mucha-Habermann disease<a class="elsevierStyleCrossRef" href="#bib0100"><span class="elsevierStyleSup">9</span></a> and etanercept was also found to be effective in a case of pityriasis lichenoides that was unresponsive to multiple treatments.<a class="elsevierStyleCrossRef" href="#bib0105"><span class="elsevierStyleSup">10</span></a> In our opinion, the development of PLC during treatment with TNF-α antagonists can also be considered a paradoxical reaction related to this relationship, just like the multiple cases of psoriasiform reactions and palmoplantar pustulosis reported over the last decade.<a class="elsevierStyleCrossRef" href="#bib0110"><span class="elsevierStyleSup">11</span></a> Although the pathogenesis and etiology of these reactions are unknown, the most widely accepted theory is an imbalance of cytokines, which would trigger the compensatory production of interferon and the development of paradoxical reactions in genetically predisposed individuals.</p><p id="par0020" class="elsevierStylePara elsevierViewall">In conclusion, adverse cutaneous effects associated with the use of TNF-α antagonists are more common than originally estimated, and the development of immune-mediated diseases in this setting is gaining recognition as an emerging phenomenon. We have described a new case of PLC associated with adalimumab and have shown how methotrexate is an interesting treatment option due to the synergic action between this drug and TNF-α antagonists in psoriasis.</p></span>" "pdfFichero" => "main.pdf" "tienePdf" => true "NotaPie" => array:1 [ 0 => array:2 [ "etiqueta" => "☆" "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Please cite this article as: Martínez-Peinado C, Galán-Gutiérrez M, Ruiz-Villaverde R, Solorzano-Mariscal R. Pitiriasis liquenoide crónica inducida por adalimumab en paciente con psoriasis y buena respuesta a metotrexato. Actas Dermosifiliogr. 2016;107:167–169.</p>" ] ] "multimedia" => array:3 [ 0 => array:7 [ "identificador" => "fig0005" "etiqueta" => "Figure 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 1153 "Ancho" => 950 "Tamanyo" => 127980 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Rash consisting of multiple reddish-brown scaling papules, at different stages of development, on the trunk.</p>" ] ] 1 => array:7 [ "identificador" => "fig0010" "etiqueta" => "Figure 2" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr2.jpeg" "Alto" => 749 "Ancho" => 995 "Tamanyo" => 313181 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Psoriasiform acanthosis with parakeratosis and mild superficial lymphohistiocytic inflammatory infiltrate with extravasation of some red blood cells. Focal vacuolar changes in basal keratinocytes (original magnification, hematoxylin-eosin ×<span class="elsevierStyleHsp" style=""></span>100).</p>" ] ] 2 => array:7 [ "identificador" => "fig0015" "etiqueta" => "Figure 3" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr3.jpeg" "Alto" => 1376 "Ancho" => 950 "Tamanyo" => 125624 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Resolution of rash and residual lesions after 6 weeks of methotrexate 15<span class="elsevierStyleHsp" style=""></span>mg a week associated with adalimumab 40<span class="elsevierStyleHsp" style=""></span>mg every 2 weeks.</p>" ] ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:11 [ 0 => array:3 [ "identificador" => "bib0060" "etiqueta" => "1" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Skin lesions and treatment with tumor necrosis factor alpha antagonists [Article in English, Spanish]" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "M.V. 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año/Mes | Html | Total | |
---|---|---|---|
2024 Noviembre | 3 | 4 | 7 |
2024 Octubre | 87 | 49 | 136 |
2024 Septiembre | 79 | 40 | 119 |
2024 Agosto | 134 | 74 | 208 |
2024 Julio | 132 | 73 | 205 |
2024 Junio | 116 | 40 | 156 |
2024 Mayo | 107 | 38 | 145 |
2024 Abril | 109 | 35 | 144 |
2024 Marzo | 110 | 37 | 147 |
2024 Febrero | 107 | 38 | 145 |
2024 Enero | 84 | 32 | 116 |
2023 Diciembre | 109 | 32 | 141 |
2023 Noviembre | 124 | 35 | 159 |
2023 Octubre | 91 | 32 | 123 |
2023 Septiembre | 99 | 40 | 139 |
2023 Agosto | 91 | 31 | 122 |
2023 Julio | 97 | 41 | 138 |
2023 Junio | 98 | 49 | 147 |
2023 Mayo | 120 | 35 | 155 |
2023 Abril | 90 | 36 | 126 |
2023 Marzo | 116 | 45 | 161 |
2023 Febrero | 109 | 36 | 145 |
2023 Enero | 67 | 34 | 101 |
2022 Diciembre | 82 | 43 | 125 |
2022 Noviembre | 55 | 31 | 86 |
2022 Octubre | 41 | 23 | 64 |
2022 Septiembre | 57 | 34 | 91 |
2022 Agosto | 40 | 36 | 76 |
2022 Julio | 45 | 26 | 71 |
2022 Junio | 34 | 24 | 58 |
2022 Mayo | 72 | 34 | 106 |
2022 Abril | 76 | 31 | 107 |
2022 Marzo | 79 | 36 | 115 |
2022 Febrero | 60 | 23 | 83 |
2022 Enero | 72 | 38 | 110 |
2021 Diciembre | 48 | 27 | 75 |
2021 Noviembre | 105 | 47 | 152 |
2021 Octubre | 139 | 55 | 194 |
2021 Septiembre | 83 | 42 | 125 |
2021 Agosto | 75 | 42 | 117 |
2021 Julio | 68 | 32 | 100 |
2021 Junio | 62 | 24 | 86 |
2021 Mayo | 70 | 48 | 118 |
2021 Abril | 194 | 56 | 250 |
2021 Marzo | 108 | 28 | 136 |
2021 Febrero | 103 | 31 | 134 |
2021 Enero | 64 | 32 | 96 |
2020 Diciembre | 45 | 28 | 73 |
2020 Noviembre | 47 | 29 | 76 |
2020 Octubre | 53 | 13 | 66 |
2020 Septiembre | 46 | 15 | 61 |
2020 Agosto | 32 | 20 | 52 |
2020 Julio | 57 | 22 | 79 |
2020 Junio | 57 | 31 | 88 |
2020 Mayo | 34 | 16 | 50 |
2020 Abril | 42 | 23 | 65 |
2020 Marzo | 30 | 30 | 60 |
2020 Febrero | 2 | 1 | 3 |
2020 Enero | 4 | 0 | 4 |
2019 Diciembre | 8 | 0 | 8 |
2019 Noviembre | 5 | 0 | 5 |
2019 Septiembre | 5 | 0 | 5 |
2019 Agosto | 4 | 0 | 4 |
2019 Julio | 4 | 0 | 4 |
2019 Junio | 6 | 0 | 6 |
2019 Mayo | 7 | 1 | 8 |
2019 Abril | 2 | 5 | 7 |
2019 Marzo | 4 | 4 | 8 |
2019 Febrero | 2 | 0 | 2 |
2019 Enero | 3 | 0 | 3 |
2018 Diciembre | 2 | 0 | 2 |
2018 Noviembre | 1 | 0 | 1 |
2018 Octubre | 6 | 0 | 6 |
2018 Septiembre | 4 | 0 | 4 |
2018 Abril | 0 | 1 | 1 |
2018 Marzo | 6 | 8 | 14 |
2018 Febrero | 26 | 16 | 42 |
2018 Enero | 34 | 12 | 46 |
2017 Diciembre | 35 | 13 | 48 |
2017 Noviembre | 21 | 14 | 35 |
2017 Octubre | 31 | 13 | 44 |
2017 Septiembre | 7 | 16 | 23 |
2017 Agosto | 28 | 15 | 43 |
2017 Julio | 30 | 16 | 46 |
2017 Junio | 19 | 20 | 39 |
2017 Mayo | 30 | 36 | 66 |
2017 Abril | 14 | 13 | 27 |
2017 Marzo | 17 | 43 | 60 |
2017 Febrero | 19 | 14 | 33 |
2017 Enero | 12 | 15 | 27 |
2016 Diciembre | 30 | 21 | 51 |
2016 Noviembre | 26 | 21 | 47 |
2016 Octubre | 22 | 31 | 53 |
2016 Septiembre | 0 | 3 | 3 |
2016 Julio | 2 | 3 | 5 |
2016 Junio | 0 | 4 | 4 |