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diabetic man&#44; with no known allergies&#44; who had a history of unstable moderate to severe plaque psoriasis of 20 years&#8217; duration associated with psoriatic arthritis of 3 years&#8217; duration&#46; The patient had been treated with topical drugs &#40;various&#41;&#44; systemic therapy &#40;oral acitretin&#41;&#44; and subsequently&#44; biologic therapy &#40;etanercept&#8212;interrupted at 15 months due to a loss of effectiveness&#8212;and ustekinumab&#8212;interrupted at 9 months due to lack of indication for use in psoriatic arthritis at the time of diagnosis&#41;&#46; The patient&#44; with a Psoriasis Area and Severity Index &#40;PASI&#41; score of 12 and a body surface area score of 18&#44; eventually continued treatment with adalimumab 40<span class="elsevierStyleHsp" style=""></span>mg&#44; and achieved PASI 0 at 8 weeks&#44; with resolution of joint pain&#46; Shortly afterwards&#44; he reported the appearance of an intermittent rash consisting of small asymptomatic lesions that did not coincide with the presence of infections or fever or the use of other medications&#46; The rashes had been believed to be outbreaks of guttate psoriasis for a period of 8 months&#44; and did not resolve on interruption of adalimumab therapy&#46; Examination revealed multiple&#44; small&#44; firm scaling erythematous papules that covered large areas of the trunk and the proximal extremities&#44; with sparing of the palms&#44; soles&#44; and mucous membranes&#46; The lesions were at different stages of development&#59; some were residual pigmented lesions&#44; while others had a lichenoid appearance with thin&#44; superficial micaceous scales &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>&#41;&#46; The diagnosis was revisited&#44; and laboratory tests&#44; including complete blood count&#44; biochemistry&#44; serology&#44; antistreptolysin O&#44; and antinuclear antibodies&#44; were ordered&#46; All the results were negative or within normal ranges&#46; Skin biopsy showed psoriasiform acanthosis with minimal parakeratosis&#44; a discrete perivascular lymphohistiocytic inflammatory infiltrate and extravasated red blood cells&#44; and isolated vacuolar changes in the basal layer&#44; in addition to minimal epidermal lymphocytic exocytosis and isolated necrotic keratinocytes &#40;<a class="elsevierStyleCrossRef" href="#fig0010">Fig&#46; 2</a>&#41;&#46; These findings were consistent with a diagnosis of pityriasis lichenoides chronica &#40;PLC&#41;&#46; It was decided to add methotrexate 15<span class="elsevierStyleHsp" style=""></span>mg weekly to the existing treatment with adalimumab&#46; The rash resolved at 6 weeks&#44; and the methotrexate dose was subsequently reduced&#44; and the treatment withdrawn at 10 weeks&#46; Three months later&#44; the patient reported new lesions&#44; which were again brought under control with methotrexate&#46; After 6 months of follow-up&#44; the patient remains asymptomatic &#40;<a class="elsevierStyleCrossRef" href="#fig0015">Fig&#46; 3</a>&#41;&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><elsevierMultimedia ident="fig0010"></elsevierMultimedia><elsevierMultimedia ident="fig0015"></elsevierMultimedia><p id="par0015" class="elsevierStylePara elsevierViewall">Many adverse skin reactions have been reported in association with TNF-&#945; antagonists&#46;<a class="elsevierStyleCrossRef" href="#bib0070"><span class="elsevierStyleSup">3</span></a> In a recent publication&#44; Newell et al&#46;<a class="elsevierStyleCrossRef" href="#bib0075"><span class="elsevierStyleSup">4</span></a> reported the development of PLC in a patient with psoriasis after the third infusion of infliximab&#44; and in a later study&#44; Said et al&#46;<a class="elsevierStyleCrossRef" href="#bib0080"><span class="elsevierStyleSup">5</span></a> published 2 cases of PLC in patients with Crohn disease under treatment with adalimumab&#46; In both cases&#44; complete remission was achieved following the addition of methotrexate&#46; L&#243;pez-Ferrer et al&#46;<a class="elsevierStyleCrossRef" href="#bib0085"><span class="elsevierStyleSup">6</span></a> also described a case of PLC after the use of infliximab in a patient with ankylosing spondylitis and ulcerative colitis&#46; A favorable response was also observed when methotrexate was added&#46; Finally&#44; Echeverri et al&#46;<a class="elsevierStyleCrossRef" href="#bib0090"><span class="elsevierStyleSup">7</span></a> published a case of PLC that appeared during week 6 of etanercept therapy in a patient with rheumatoid arthritis&#46; The condition improved with the use of topical corticosteroids&#46; Our case is the sixth report in the literature of PLC induced by a TNF-&#945; antagonist and the first of good response to methotrexate in a patient with psoriasis being treated with adalimumab&#46; Although we cannot rule out spontaneous resolution&#44; our experience is similar to that reported by Said et al&#46; and L&#243;pez-Ferrer et al&#46; What causes pityriasis lichenoid and its variants remains unknown&#44;<a class="elsevierStyleCrossRef" href="#bib0095"><span class="elsevierStyleSup">8</span></a> but TNF-&#945; appears to have a role&#44; as increased serum levels of this cytokine have been reported in a patient with febrile ulceronecrotic Mucha-Habermann disease<a class="elsevierStyleCrossRef" href="#bib0100"><span class="elsevierStyleSup">9</span></a> and etanercept was also found to be effective in a case of pityriasis lichenoides that was unresponsive to multiple treatments&#46;<a class="elsevierStyleCrossRef" href="#bib0105"><span class="elsevierStyleSup">10</span></a> In our opinion&#44; the development of PLC during treatment with TNF-&#945; antagonists can also be considered a paradoxical reaction related to this relationship&#44; just like the multiple cases of psoriasiform reactions and palmoplantar pustulosis reported over the last decade&#46;<a class="elsevierStyleCrossRef" href="#bib0110"><span class="elsevierStyleSup">11</span></a> Although the pathogenesis and etiology of these reactions are unknown&#44; the most widely accepted theory is an imbalance of cytokines&#44; which would trigger the compensatory production of interferon and the development of paradoxical reactions in genetically predisposed individuals&#46;</p><p id="par0020" class="elsevierStylePara elsevierViewall">In conclusion&#44; adverse cutaneous effects associated with the use of TNF-&#945; antagonists are more common than originally estimated&#44; and the development of immune-mediated diseases in this setting is gaining recognition as an emerging phenomenon&#46; We have described a new case of PLC associated with adalimumab and have shown how methotrexate is an interesting treatment option due to the synergic action between this drug and TNF-&#945; antagonists in psoriasis&#46;</p></span>"
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    "bibliografia" => array:2 [
      "titulo" => "References"
      "seccion" => array:1 [
        0 => array:2 [
          "identificador" => "bibs0005"
          "bibliografiaReferencia" => array:11 [
            0 => array:3 [
              "identificador" => "bib0060"
              "etiqueta" => "1"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Skin lesions and treatment with tumor necrosis factor alpha antagonists &#91;Article in English&#44; Spanish&#93;"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "M&#46;V&#46; Hern&#225;ndez"
                            1 => "M&#46; Meineri"
                            2 => "R&#46; Sanmart&#237;"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.reuma.2012.04.007"
                      "Revista" => array:6 [
                        "tituloSerie" => "Reumatol Clin"
                        "fecha" => "2013"
                        "volumen" => "9"
                        "paginaInicial" => "53"
                        "paginaFinal" => "56"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/22766431"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            1 => array:3 [
              "identificador" => "bib0065"
              "etiqueta" => "2"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Cutaneous side-effects in patients with rheumatic diseases during application of tumour necrosis factor-alpha-antagonists"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "H&#46;H&#46; Lee"
                            1 => "I&#46;H&#46; Song"
                            2 => "M&#46; Friedrich"
                            3 => "A&#46; Gauliard"
                            4 => "J&#46; Detert"
                            5 => "J&#46; R&#246;wert"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1111/j.1365-2133.2007.07682.x"
                      "Revista" => array:6 [
                        "tituloSerie" => "Br J Dermatol"
                        "fecha" => "2007"
                        "volumen" => "156"
                        "paginaInicial" => "486"
                        "paginaFinal" => "491"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17300238"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            2 => array:3 [
              "identificador" => "bib0070"
              "etiqueta" => "3"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Cutaneous adverse effects of biological therapies for psoriasis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "E&#46; Ro&#233;"
                            1 => "L&#46; Puig"
                            2 => "F&#46; Corella"
                            3 => "X&#46; Garc&#237;a-Navarro"
                            4 => "A&#46; Alomar"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1684/ejd.2008.0521"
                      "Revista" => array:6 [
                        "tituloSerie" => "Eur J Dermatol"
                        "fecha" => "2008"
                        "volumen" => "18"
                        "paginaInicial" => "693"
                        "paginaFinal" => "699"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18955203"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            3 => array:3 [
              "identificador" => "bib0075"
              "etiqueta" => "4"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Infliximab-induced pityriasis lichenoides chronica in a patient with psoriasis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "E&#46;L&#46; Newell"
                            1 => "S&#46; Jain"
                            2 => "C&#46; Stephens"
                            3 => "G&#46; Martland"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1111/j.1468-3083.2008.02818.x"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Eur Acad Dermatol Venereol"
                        "fecha" => "2009"
                        "volumen" => "23"
                        "paginaInicial" => "230"
                        "paginaFinal" => "231"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18680531"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            4 => array:3 [
              "identificador" => "bib0080"
              "etiqueta" => "5"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Pityriasis lichenoides chronica induced by adalimumab therapy for Crohn&#39;s disease&#58; Report of 2 cases successfully treated with methotrexate"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "B&#46;B&#46; Said"
                            1 => "J&#46; Kanitakis"
                            2 => "I&#46; Graber"
                            3 => "J&#46;F&#46; Nicolas"
                            4 => "J&#46;C&#46; Saurin"
                            5 => "F&#46; Berard"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1002/ibd.21110"
                      "Revista" => array:6 [
                        "tituloSerie" => "Inflamm Bowel Dis"
                        "fecha" => "2009"
                        "volumen" => "16"
                        "paginaInicial" => "912"
                        "paginaFinal" => "913"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19821511"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            5 => array:3 [
              "identificador" => "bib0085"
              "etiqueta" => "6"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Pityriasis lichenoides chronica induced by infliximab&#44; with response to methotrexate"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "A&#46; L&#243;pez-Ferrer"
                            1 => "L&#46; Puig"
                            2 => "G&#46; Moreno"
                            3 => "A&#46; Camps-Fresneda"
                            4 => "J&#46; Palou"
                            5 => "A&#46; Alomar"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1684/ejd.2010.0958"
                      "Revista" => array:6 [
                        "tituloSerie" => "Eur J Dermatol"
                        "fecha" => "2010"
                        "volumen" => "20"
                        "paginaInicial" => "511"
                        "paginaFinal" => "512"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/20395191"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            6 => array:3 [
              "identificador" => "bib0090"
              "etiqueta" => "7"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Etanercept-induced pityriasis lichenoides chronica in a patient with rheumatoid arthritis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "A&#46;F&#46; Echeverri"
                            1 => "A&#46; Vidal"
                            2 => "C&#46;A&#46; Ca&#241;as"
                            3 => "A&#46; Agualimpia"
                            4 => "G&#46;J&#46; Tob&#243;n"
                            5 => "F&#46; Bonilla-Abad&#237;a"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1155/2015/168063"
                      "Revista" => array:5 [
                        "tituloSerie" => "Case Rep Dermatol Med&#46;"
                        "fecha" => "2015"
                        "volumen" => "2015"
                        "paginaInicial" => "168063"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/25789178"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            7 => array:3 [
              "identificador" => "bib0095"
              "etiqueta" => "8"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Pityriasis lichenoides and its subtypes"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "S&#46; Bowers"
                            1 => "E&#46;M&#46; Warshaw"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.jaad.2005.07.058"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Am Acad Dermatol"
                        "fecha" => "2006"
                        "volumen" => "55"
                        "paginaInicial" => "557"
                        "paginaFinal" => "572"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17010734"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            8 => array:3 [
              "identificador" => "bib0100"
              "etiqueta" => "9"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Transition of pityriasis lichenoides et varioliformis acuta to febrile ulceronecrotic Mucha-Habermann disease is associated with elevated serum tumour necrosis factor-alpha"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "A&#46; Tsianakas"
                            1 => "P&#46;H&#46; Hoeger"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1111/j.1365-2133.2005.06485.x"
                      "Revista" => array:6 [
                        "tituloSerie" => "Br J Dermatol"
                        "fecha" => "2005"
                        "volumen" => "152"
                        "paginaInicial" => "794"
                        "paginaFinal" => "799"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15840118"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            9 => array:3 [
              "identificador" => "bib0105"
              "etiqueta" => "10"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Etanercept in therapy multiresistant overlapping pityriasis lichenoides"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "A&#46;F&#46; Nikkels"
                            1 => "P&#46; Gillard"
                            2 => "G&#46;E&#46; Pierard"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "J Drugs Dermatol"
                        "fecha" => "2008"
                        "volumen" => "7"
                        "paginaInicial" => "990"
                        "paginaFinal" => "992"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19112768"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            10 => array:3 [
              "identificador" => "bib0110"
              "etiqueta" => "11"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Reacciones psoriasiformes parad&#243;jicas durante el tratamiento con terapia anti-factor de necrosis tumoral&#46; Manejo cl&#237;nico"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "R&#46; Navarro"
                            1 => "E&#46; Daud&#233;n"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.ad.2013.05.007"
                      "Revista" => array:6 [
                        "tituloSerie" => "Actas Dermosifiliogr"
                        "fecha" => "2014"
                        "volumen" => "105"
                        "paginaInicial" => "752"
                        "paginaFinal" => "761"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/23938073"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
          ]
        ]
      ]
    ]
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Case and Research Letters
Adalimumab-Induced Pityriasis Lichenoides Chronica That Responded Well to Methotrexate in a Patient With Psoriasis
Pitiriasis liquenoide crónica inducida por adalimumab en paciente con psoriasis y buena respuesta a metotrexato
C. Martínez-Peinadoa,
Autor para correspondencia
carpeinado@hotmail.es

Corresponding author.
, M. Galán-Gutiérreza, R. Ruiz-Villaverdeb, R. Solorzano-Mariscalc
a Unidad de Gestión Clínica de CMA-Dermatología Médico Quirúrgica y Venereología, Complejo Hospitalario de Jaén, Jaén, Spain
b Unidad de Gestión Clínica de Dermatología Médico Quirúrgica y Venereología, Hospital Universitario Virgen de las Nieves, Granada, Spain
c Servicio de Anatomía Patológica, Complejo Hospitalario de Jaén, Jaén, Spain
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diabetic man&#44; with no known allergies&#44; who had a history of unstable moderate to severe plaque psoriasis of 20 years&#8217; duration associated with psoriatic arthritis of 3 years&#8217; duration&#46; The patient had been treated with topical drugs &#40;various&#41;&#44; systemic therapy &#40;oral acitretin&#41;&#44; and subsequently&#44; biologic therapy &#40;etanercept&#8212;interrupted at 15 months due to a loss of effectiveness&#8212;and ustekinumab&#8212;interrupted at 9 months due to lack of indication for use in psoriatic arthritis at the time of diagnosis&#41;&#46; The patient&#44; with a Psoriasis Area and Severity Index &#40;PASI&#41; score of 12 and a body surface area score of 18&#44; eventually continued treatment with adalimumab 40<span class="elsevierStyleHsp" style=""></span>mg&#44; and achieved PASI 0 at 8 weeks&#44; with resolution of joint pain&#46; Shortly afterwards&#44; he reported the appearance of an intermittent rash consisting of small asymptomatic lesions that did not coincide with the presence of infections or fever or the use of other medications&#46; The rashes had been believed to be outbreaks of guttate psoriasis for a period of 8 months&#44; and did not resolve on interruption of adalimumab therapy&#46; Examination revealed multiple&#44; small&#44; firm scaling erythematous papules that covered large areas of the trunk and the proximal extremities&#44; with sparing of the palms&#44; soles&#44; and mucous membranes&#46; The lesions were at different stages of development&#59; some were residual pigmented lesions&#44; while others had a lichenoid appearance with thin&#44; superficial micaceous scales &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>&#41;&#46; The diagnosis was revisited&#44; and laboratory tests&#44; including complete blood count&#44; biochemistry&#44; serology&#44; antistreptolysin O&#44; and antinuclear antibodies&#44; were ordered&#46; All the results were negative or within normal ranges&#46; Skin biopsy showed psoriasiform acanthosis with minimal parakeratosis&#44; a discrete perivascular lymphohistiocytic inflammatory infiltrate and extravasated red blood cells&#44; and isolated vacuolar changes in the basal layer&#44; in addition to minimal epidermal lymphocytic exocytosis and isolated necrotic keratinocytes &#40;<a class="elsevierStyleCrossRef" href="#fig0010">Fig&#46; 2</a>&#41;&#46; These findings were consistent with a diagnosis of pityriasis lichenoides chronica &#40;PLC&#41;&#46; It was decided to add methotrexate 15<span class="elsevierStyleHsp" style=""></span>mg weekly to the existing treatment with adalimumab&#46; The rash resolved at 6 weeks&#44; and the methotrexate dose was subsequently reduced&#44; and the treatment withdrawn at 10 weeks&#46; Three months later&#44; the patient reported new lesions&#44; which were again brought under control with methotrexate&#46; After 6 months of follow-up&#44; the patient remains asymptomatic &#40;<a class="elsevierStyleCrossRef" href="#fig0015">Fig&#46; 3</a>&#41;&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><elsevierMultimedia ident="fig0010"></elsevierMultimedia><elsevierMultimedia ident="fig0015"></elsevierMultimedia><p id="par0015" class="elsevierStylePara elsevierViewall">Many adverse skin reactions have been reported in association with TNF-&#945; antagonists&#46;<a class="elsevierStyleCrossRef" href="#bib0070"><span class="elsevierStyleSup">3</span></a> In a recent publication&#44; Newell et al&#46;<a class="elsevierStyleCrossRef" href="#bib0075"><span class="elsevierStyleSup">4</span></a> reported the development of PLC in a patient with psoriasis after the third infusion of infliximab&#44; and in a later study&#44; Said et al&#46;<a class="elsevierStyleCrossRef" href="#bib0080"><span class="elsevierStyleSup">5</span></a> published 2 cases of PLC in patients with Crohn disease under treatment with adalimumab&#46; In both cases&#44; complete remission was achieved following the addition of methotrexate&#46; L&#243;pez-Ferrer et al&#46;<a class="elsevierStyleCrossRef" href="#bib0085"><span class="elsevierStyleSup">6</span></a> also described a case of PLC after the use of infliximab in a patient with ankylosing spondylitis and ulcerative colitis&#46; A favorable response was also observed when methotrexate was added&#46; Finally&#44; Echeverri et al&#46;<a class="elsevierStyleCrossRef" href="#bib0090"><span class="elsevierStyleSup">7</span></a> published a case of PLC that appeared during week 6 of etanercept therapy in a patient with rheumatoid arthritis&#46; The condition improved with the use of topical corticosteroids&#46; Our case is the sixth report in the literature of PLC induced by a TNF-&#945; antagonist and the first of good response to methotrexate in a patient with psoriasis being treated with adalimumab&#46; Although we cannot rule out spontaneous resolution&#44; our experience is similar to that reported by Said et al&#46; and L&#243;pez-Ferrer et al&#46; What causes pityriasis lichenoid and its variants remains unknown&#44;<a class="elsevierStyleCrossRef" href="#bib0095"><span class="elsevierStyleSup">8</span></a> but TNF-&#945; appears to have a role&#44; as increased serum levels of this cytokine have been reported in a patient with febrile ulceronecrotic Mucha-Habermann disease<a class="elsevierStyleCrossRef" href="#bib0100"><span class="elsevierStyleSup">9</span></a> and etanercept was also found to be effective in a case of pityriasis lichenoides that was unresponsive to multiple treatments&#46;<a class="elsevierStyleCrossRef" href="#bib0105"><span class="elsevierStyleSup">10</span></a> In our opinion&#44; the development of PLC during treatment with TNF-&#945; antagonists can also be considered a paradoxical reaction related to this relationship&#44; just like the multiple cases of psoriasiform reactions and palmoplantar pustulosis reported over the last decade&#46;<a class="elsevierStyleCrossRef" href="#bib0110"><span class="elsevierStyleSup">11</span></a> Although the pathogenesis and etiology of these reactions are unknown&#44; the most widely accepted theory is an imbalance of cytokines&#44; which would trigger the compensatory production of interferon and the development of paradoxical reactions in genetically predisposed individuals&#46;</p><p id="par0020" class="elsevierStylePara elsevierViewall">In conclusion&#44; adverse cutaneous effects associated with the use of TNF-&#945; antagonists are more common than originally estimated&#44; and the development of immune-mediated diseases in this setting is gaining recognition as an emerging phenomenon&#46; We have described a new case of PLC associated with adalimumab and have shown how methotrexate is an interesting treatment option due to the synergic action between this drug and TNF-&#945; antagonists in psoriasis&#46;</p></span>"
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      "titulo" => "References"
      "seccion" => array:1 [
        0 => array:2 [
          "identificador" => "bibs0005"
          "bibliografiaReferencia" => array:11 [
            0 => array:3 [
              "identificador" => "bib0060"
              "etiqueta" => "1"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Skin lesions and treatment with tumor necrosis factor alpha antagonists &#91;Article in English&#44; Spanish&#93;"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "M&#46;V&#46; Hern&#225;ndez"
                            1 => "M&#46; Meineri"
                            2 => "R&#46; Sanmart&#237;"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.reuma.2012.04.007"
                      "Revista" => array:6 [
                        "tituloSerie" => "Reumatol Clin"
                        "fecha" => "2013"
                        "volumen" => "9"
                        "paginaInicial" => "53"
                        "paginaFinal" => "56"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/22766431"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            1 => array:3 [
              "identificador" => "bib0065"
              "etiqueta" => "2"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Cutaneous side-effects in patients with rheumatic diseases during application of tumour necrosis factor-alpha-antagonists"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "H&#46;H&#46; Lee"
                            1 => "I&#46;H&#46; Song"
                            2 => "M&#46; Friedrich"
                            3 => "A&#46; Gauliard"
                            4 => "J&#46; Detert"
                            5 => "J&#46; R&#246;wert"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1111/j.1365-2133.2007.07682.x"
                      "Revista" => array:6 [
                        "tituloSerie" => "Br J Dermatol"
                        "fecha" => "2007"
                        "volumen" => "156"
                        "paginaInicial" => "486"
                        "paginaFinal" => "491"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17300238"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            2 => array:3 [
              "identificador" => "bib0070"
              "etiqueta" => "3"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Cutaneous adverse effects of biological therapies for psoriasis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "E&#46; Ro&#233;"
                            1 => "L&#46; Puig"
                            2 => "F&#46; Corella"
                            3 => "X&#46; Garc&#237;a-Navarro"
                            4 => "A&#46; Alomar"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1684/ejd.2008.0521"
                      "Revista" => array:6 [
                        "tituloSerie" => "Eur J Dermatol"
                        "fecha" => "2008"
                        "volumen" => "18"
                        "paginaInicial" => "693"
                        "paginaFinal" => "699"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18955203"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            3 => array:3 [
              "identificador" => "bib0075"
              "etiqueta" => "4"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Infliximab-induced pityriasis lichenoides chronica in a patient with psoriasis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "E&#46;L&#46; Newell"
                            1 => "S&#46; Jain"
                            2 => "C&#46; Stephens"
                            3 => "G&#46; Martland"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1111/j.1468-3083.2008.02818.x"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Eur Acad Dermatol Venereol"
                        "fecha" => "2009"
                        "volumen" => "23"
                        "paginaInicial" => "230"
                        "paginaFinal" => "231"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18680531"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            4 => array:3 [
              "identificador" => "bib0080"
              "etiqueta" => "5"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Pityriasis lichenoides chronica induced by adalimumab therapy for Crohn&#39;s disease&#58; Report of 2 cases successfully treated with methotrexate"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "B&#46;B&#46; Said"
                            1 => "J&#46; Kanitakis"
                            2 => "I&#46; Graber"
                            3 => "J&#46;F&#46; Nicolas"
                            4 => "J&#46;C&#46; Saurin"
                            5 => "F&#46; Berard"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1002/ibd.21110"
                      "Revista" => array:6 [
                        "tituloSerie" => "Inflamm Bowel Dis"
                        "fecha" => "2009"
                        "volumen" => "16"
                        "paginaInicial" => "912"
                        "paginaFinal" => "913"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19821511"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            5 => array:3 [
              "identificador" => "bib0085"
              "etiqueta" => "6"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Pityriasis lichenoides chronica induced by infliximab&#44; with response to methotrexate"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "A&#46; L&#243;pez-Ferrer"
                            1 => "L&#46; Puig"
                            2 => "G&#46; Moreno"
                            3 => "A&#46; Camps-Fresneda"
                            4 => "J&#46; Palou"
                            5 => "A&#46; Alomar"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1684/ejd.2010.0958"
                      "Revista" => array:6 [
                        "tituloSerie" => "Eur J Dermatol"
                        "fecha" => "2010"
                        "volumen" => "20"
                        "paginaInicial" => "511"
                        "paginaFinal" => "512"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/20395191"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            6 => array:3 [
              "identificador" => "bib0090"
              "etiqueta" => "7"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Etanercept-induced pityriasis lichenoides chronica in a patient with rheumatoid arthritis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "A&#46;F&#46; Echeverri"
                            1 => "A&#46; Vidal"
                            2 => "C&#46;A&#46; Ca&#241;as"
                            3 => "A&#46; Agualimpia"
                            4 => "G&#46;J&#46; Tob&#243;n"
                            5 => "F&#46; Bonilla-Abad&#237;a"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1155/2015/168063"
                      "Revista" => array:5 [
                        "tituloSerie" => "Case Rep Dermatol Med&#46;"
                        "fecha" => "2015"
                        "volumen" => "2015"
                        "paginaInicial" => "168063"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/25789178"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            7 => array:3 [
              "identificador" => "bib0095"
              "etiqueta" => "8"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Pityriasis lichenoides and its subtypes"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "S&#46; Bowers"
                            1 => "E&#46;M&#46; Warshaw"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.jaad.2005.07.058"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Am Acad Dermatol"
                        "fecha" => "2006"
                        "volumen" => "55"
                        "paginaInicial" => "557"
                        "paginaFinal" => "572"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17010734"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            8 => array:3 [
              "identificador" => "bib0100"
              "etiqueta" => "9"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Transition of pityriasis lichenoides et varioliformis acuta to febrile ulceronecrotic Mucha-Habermann disease is associated with elevated serum tumour necrosis factor-alpha"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "A&#46; Tsianakas"
                            1 => "P&#46;H&#46; Hoeger"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1111/j.1365-2133.2005.06485.x"
                      "Revista" => array:6 [
                        "tituloSerie" => "Br J Dermatol"
                        "fecha" => "2005"
                        "volumen" => "152"
                        "paginaInicial" => "794"
                        "paginaFinal" => "799"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15840118"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            9 => array:3 [
              "identificador" => "bib0105"
              "etiqueta" => "10"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Etanercept in therapy multiresistant overlapping pityriasis lichenoides"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "A&#46;F&#46; Nikkels"
                            1 => "P&#46; Gillard"
                            2 => "G&#46;E&#46; Pierard"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "J Drugs Dermatol"
                        "fecha" => "2008"
                        "volumen" => "7"
                        "paginaInicial" => "990"
                        "paginaFinal" => "992"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19112768"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            10 => array:3 [
              "identificador" => "bib0110"
              "etiqueta" => "11"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Reacciones psoriasiformes parad&#243;jicas durante el tratamiento con terapia anti-factor de necrosis tumoral&#46; Manejo cl&#237;nico"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "R&#46; Navarro"
                            1 => "E&#46; Daud&#233;n"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.ad.2013.05.007"
                      "Revista" => array:6 [
                        "tituloSerie" => "Actas Dermosifiliogr"
                        "fecha" => "2014"
                        "volumen" => "105"
                        "paginaInicial" => "752"
                        "paginaFinal" => "761"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/23938073"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
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ISSN: 15782190
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2016 Septiembre 0 3 3
2016 Julio 2 3 5
2016 Junio 0 4 4
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¿Es usted profesional sanitario apto para prescribir o dispensar medicamentos?

Are you a health professional able to prescribe or dispense drugs?