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Resident Forum
Detection of Oncogenic Human Papillomavirus Genotypes: A Useful Screening Tool for High-Grade Anal Intraepithelial Neoplasia
FR - Detección de genotipos oncogénicos del virus del papiloma humano: una herramienta útil en el cribado de neoplasia intraepitelial anal de alto grado
L. Padilla-España
Autor para correspondencia
eplaura85@hotmail.com

Corresponding author.
, J.F. Millán Cayetano, P. García Montero
Servicio de Dermatología, Hospital Costa del Sol, Marbella, Málaga, Spain
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    "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">High-grade anal intraepithelial neoplasia &#40;AIN&#41; is considered a precursor to anal cancer&#46; Its incidence has increased in specific risk populations&#44; especially persons infected by the human immunodeficiency virus &#40;HIV&#41; and men who have sex with men &#40;MSM&#41;&#46;<a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">1</span></a></p><p id="par0010" class="elsevierStylePara elsevierViewall">Human papillomavirus &#40;HPV&#41; has been shown to play a key pathogenic role in anal cancer &#40;up to 93&#37; of cases&#41;&#46; In fact&#44; the frequency of oncogenic genotypes 16 and 18 has increased significantly in both high-grade AIN and anal carcinoma&#46;<a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">1</span></a></p><p id="par0015" class="elsevierStylePara elsevierViewall">Although the natural course of AIN is unknown and recurrence rates of up to 29&#37; have been reported&#44; the condition sometimes progresses to infiltrating forms&#44; especially in older HIV-infected patients with CD4 T-lymphocyte counts &#60;200<span class="elsevierStyleHsp" style=""></span>cells&#47;&#956;L&#46;<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">2</span></a></p><p id="par0020" class="elsevierStylePara elsevierViewall">There is no definitive protocol for screening of AIN&#44; in part because of a lack of data on the role of screening in reducing the morbidity and mortality of anal cancer&#46; Most authors base their reports on the program proposed by Chin-Hong and Palefsky&#44;<a class="elsevierStyleCrossRef" href="#bib0040"><span class="elsevierStyleSup">3</span></a> which does not take into account HPV genotyping as an initial screening test&#46;</p><p id="par0025" class="elsevierStylePara elsevierViewall">Screening for AIN is based on the combination of anal cytology and high-resolution anoscopy&#44; as in screening for cervical cancer&#46; However&#44; it is important to remember that anal cytology can lead high-grade AIN to be underdiagnosed&#44; especially in immunodepressed patients &#40;up to 52&#46;7&#37; cases according to Botes et al<span class="elsevierStyleItalic">&#46;</span><a class="elsevierStyleCrossRef" href="#bib0045"><span class="elsevierStyleSup">4</span></a>&#41;&#46;</p><p id="par0030" class="elsevierStylePara elsevierViewall">Hybrid capture assay and HPV genotyping tests were recently proposed as complementary tools in screening for AIN&#46; Risk genotypes are detected using microplate DNA hybridization assay and subsequent chemiluminescence signal amplification for the qualitative detection of different genotypes of low- and high-risk HPV&#46; This technique is supported by several correlation studies &#40;performed specifically in HIV-infected patients&#41; that compare the findings of both diagnostic methods &#40;anal cytology and detection of HPV&#41;&#44; with a strong association between high-grade dysplasia and infection by multiple high-risk HPV genotypes&#46;<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">2</span></a></p><p id="par0035" class="elsevierStylePara elsevierViewall">Detection of high-risk genotypes could prove to be essential in high-risk populations&#44; such as HIV-infected patients and MSM&#44; in whom anal cytology does not show dysplasia to be present&#46; In these cases&#44; a meticulous examination of the anal canal should be performed using high-resolution anoscopy that enables suspected high-grade AIN lesions to be identified and biopsied &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>&#41;&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><p id="par0040" class="elsevierStylePara elsevierViewall">Therefore&#44; the latest trends point to HPV genotyping as the most sensitive and specific tool when screening for AIN&#46;<a class="elsevierStyleCrossRef" href="#bib0050"><span class="elsevierStyleSup">5</span></a> Nevertheless&#44; it is necessary to perform sensitivity and cost-effectiveness studies to compare the various diagnostic procedures used in screening with anoscopy-guided biopsy&#44; which continues to be the definitive confirmatory diagnostic test&#46;</p></span>"
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          "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Screening algorithm for AIN based on analy cytology and taking into account the usefulness of detection of high-risk HPV genotypes&#46;</p> <p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">AIN indicates anal intraepithelial neoplasia&#59; HIV&#44; human immunodeficiency virus&#46;</p>"
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