array:24 [
  "pii" => "S1578219015002024"
  "issn" => "15782190"
  "doi" => "10.1016/j.adengl.2015.07.004"
  "estado" => "S300"
  "fechaPublicacion" => "2015-10-01"
  "aid" => "1145"
  "copyright" => "Elsevier España, S.L.U. and AEDV"
  "copyrightAnyo" => "2014"
  "documento" => "simple-article"
  "crossmark" => 1
  "subdocumento" => "cor"
  "cita" => "Actas Dermosifiliogr. 2015;106:676-8"
  "abierto" => array:3 [
    "ES" => true
    "ES2" => true
    "LATM" => true
  ]
  "gratuito" => true
  "lecturas" => array:2 [
    "total" => 908
    "formatos" => array:3 [
      "EPUB" => 48
      "HTML" => 479
      "PDF" => 381
    ]
  ]
  "Traduccion" => array:1 [
    "es" => array:19 [
      "pii" => "S0001731015001295"
      "issn" => "00017310"
      "doi" => "10.1016/j.ad.2014.12.022"
      "estado" => "S300"
      "fechaPublicacion" => "2015-10-01"
      "aid" => "1145"
      "copyright" => "Elsevier España, S.L.U. y AEDV"
      "documento" => "simple-article"
      "crossmark" => 1
      "subdocumento" => "crp"
      "cita" => "Actas Dermosifiliogr. 2015;106:676-8"
      "abierto" => array:3 [
        "ES" => true
        "ES2" => true
        "LATM" => true
      ]
      "gratuito" => true
      "lecturas" => array:2 [
        "total" => 744
        "formatos" => array:3 [
          "EPUB" => 2
          "HTML" => 378
          "PDF" => 364
        ]
      ]
      "es" => array:11 [
        "idiomaDefecto" => true
        "cabecera" => "<span class="elsevierStyleTextfn">Carta cient&#237;fico-cl&#237;nica</span>"
        "titulo" => "Alopecia e hirsutismo en una mujer posmenop&#225;usica como forma de presentaci&#243;n de un tumor de c&#233;lulas de Leydig hiliar del ovario"
        "tienePdf" => "es"
        "tieneTextoCompleto" => "es"
        "paginas" => array:1 [
          0 => array:2 [
            "paginaInicial" => "676"
            "paginaFinal" => "678"
          ]
        ]
        "titulosAlternativos" => array:1 [
          "en" => array:1 [
            "titulo" => "Alopecia and Hirsutism in a Postmenopausal Woman as the Presenting Complaint of Ovarian Hilus &#40;Leydig&#41; Cell Tumor"
          ]
        ]
        "contieneTextoCompleto" => array:1 [
          "es" => true
        ]
        "contienePdf" => array:1 [
          "es" => true
        ]
        "resumenGrafico" => array:2 [
          "original" => 0
          "multimedia" => array:7 [
            "identificador" => "fig0015"
            "etiqueta" => "Figura 3"
            "tipo" => "MULTIMEDIAFIGURA"
            "mostrarFloat" => true
            "mostrarDisplay" => false
            "figura" => array:1 [
              0 => array:4 [
                "imagen" => "gr3.jpeg"
                "Alto" => 1120
                "Ancho" => 975
                "Tamanyo" => 161737
              ]
            ]
            "descripcion" => array:1 [
              "es" => "<p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">N&#243;dulo suprarrenal izquierdo de 2&#44;6<span class="elsevierStyleHsp" style=""></span>cm&#46;</p>"
            ]
          ]
        ]
        "autores" => array:1 [
          0 => array:2 [
            "autoresLista" => "L&#46; Berbegal, M&#46;P&#46; Albares, F&#46;J&#46; De-Leon, G&#46; Negueruela"
            "autores" => array:4 [
              0 => array:2 [
                "nombre" => "L&#46;"
                "apellidos" => "Berbegal"
              ]
              1 => array:2 [
                "nombre" => "M&#46;P&#46;"
                "apellidos" => "Albares"
              ]
              2 => array:2 [
                "nombre" => "F&#46;J&#46;"
                "apellidos" => "De-Leon"
              ]
              3 => array:2 [
                "nombre" => "G&#46;"
                "apellidos" => "Negueruela"
              ]
            ]
          ]
        ]
      ]
      "idiomaDefecto" => "es"
      "Traduccion" => array:1 [
        "en" => array:9 [
          "pii" => "S1578219015002024"
          "doi" => "10.1016/j.adengl.2015.07.004"
          "estado" => "S300"
          "subdocumento" => ""
          "abierto" => array:3 [
            "ES" => true
            "ES2" => true
            "LATM" => true
          ]
          "gratuito" => true
          "lecturas" => array:1 [
            "total" => 0
          ]
          "idiomaDefecto" => "en"
          "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1578219015002024?idApp=UINPBA000044"
        ]
      ]
      "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0001731015001295?idApp=UINPBA000044"
      "url" => "/00017310/0000010600000008/v1_201510020746/S0001731015001295/v1_201510020746/es/main.assets"
    ]
  ]
  "itemSiguiente" => array:19 [
    "pii" => "S1578219015002036"
    "issn" => "15782190"
    "doi" => "10.1016/j.adengl.2015.07.005"
    "estado" => "S300"
    "fechaPublicacion" => "2015-10-01"
    "aid" => "1146"
    "copyright" => "Elsevier Espa&#241;a&#44; S&#46;L&#46;U&#46; and AEDV"
    "documento" => "simple-article"
    "crossmark" => 1
    "subdocumento" => "cor"
    "cita" => "Actas Dermosifiliogr. 2015;106:678-80"
    "abierto" => array:3 [
      "ES" => true
      "ES2" => true
      "LATM" => true
    ]
    "gratuito" => true
    "lecturas" => array:2 [
      "total" => 880
      "formatos" => array:3 [
        "EPUB" => 44
        "HTML" => 547
        "PDF" => 289
      ]
    ]
    "en" => array:11 [
      "idiomaDefecto" => true
      "cabecera" => "<span class="elsevierStyleTextfn">Case and Research Letters</span>"
      "titulo" => "Diagnostic Value of Color Doppler Ultrasound for Cutaneous Odontogenic Sinus Tract"
      "tienePdf" => "en"
      "tieneTextoCompleto" => "en"
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "678"
          "paginaFinal" => "680"
        ]
      ]
      "titulosAlternativos" => array:1 [
        "es" => array:1 [
          "titulo" => "Utilidad de la ecograf&#237;a doppler color para el diagn&#243;stico de f&#237;stulas dentocut&#225;neas"
        ]
      ]
      "contieneTextoCompleto" => array:1 [
        "en" => true
      ]
      "contienePdf" => array:1 [
        "en" => true
      ]
      "resumenGrafico" => array:2 [
        "original" => 0
        "multimedia" => array:7 [
          "identificador" => "fig0005"
          "etiqueta" => "Figure 1"
          "tipo" => "MULTIMEDIAFIGURA"
          "mostrarFloat" => true
          "mostrarDisplay" => false
          "figura" => array:1 [
            0 => array:4 [
              "imagen" => "gr1.jpeg"
              "Alto" => 1667
              "Ancho" => 1251
              "Tamanyo" => 381212
            ]
          ]
          "descripcion" => array:1 [
            "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Cutaneous horn sunken into the skin over the left horizontal ramus of the mandible&#46;</p>"
          ]
        ]
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "C&#46; Garrido Colmenero, G&#46; Blasco Morente, J&#46;M&#46; Latorre Fuentes, R&#46; Ruiz Villaverde"
          "autores" => array:4 [
            0 => array:2 [
              "nombre" => "C&#46;"
              "apellidos" => "Garrido Colmenero"
            ]
            1 => array:2 [
              "nombre" => "G&#46;"
              "apellidos" => "Blasco Morente"
            ]
            2 => array:2 [
              "nombre" => "J&#46;M&#46;"
              "apellidos" => "Latorre Fuentes"
            ]
            3 => array:2 [
              "nombre" => "R&#46;"
              "apellidos" => "Ruiz Villaverde"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "en"
    "Traduccion" => array:1 [
      "es" => array:9 [
        "pii" => "S0001731015001301"
        "doi" => "10.1016/j.ad.2014.12.023"
        "estado" => "S300"
        "subdocumento" => ""
        "abierto" => array:3 [
          "ES" => true
          "ES2" => true
          "LATM" => true
        ]
        "gratuito" => true
        "lecturas" => array:1 [
          "total" => 0
        ]
        "idiomaDefecto" => "es"
        "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0001731015001301?idApp=UINPBA000044"
      ]
    ]
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1578219015002036?idApp=UINPBA000044"
    "url" => "/15782190/0000010600000008/v1_201510011018/S1578219015002036/v1_201510011018/en/main.assets"
  ]
  "itemAnterior" => array:19 [
    "pii" => "S1578219015002012"
    "issn" => "15782190"
    "doi" => "10.1016/j.adengl.2015.07.003"
    "estado" => "S300"
    "fechaPublicacion" => "2015-10-01"
    "aid" => "1143"
    "copyright" => "Elsevier Espa&#241;a&#44; S&#46;L&#46;U&#46; and AEDV"
    "documento" => "simple-article"
    "crossmark" => 1
    "subdocumento" => "cor"
    "cita" => "Actas Dermosifiliogr. 2015;106:675-6"
    "abierto" => array:3 [
      "ES" => true
      "ES2" => true
      "LATM" => true
    ]
    "gratuito" => true
    "lecturas" => array:2 [
      "total" => 976
      "formatos" => array:3 [
        "EPUB" => 41
        "HTML" => 558
        "PDF" => 377
      ]
    ]
    "en" => array:11 [
      "idiomaDefecto" => true
      "cabecera" => "<span class="elsevierStyleTextfn">Case and Research Letters</span>"
      "titulo" => "Cell Phone-Induced Chondrodermatitis Nodularis Antihelicis"
      "tienePdf" => "en"
      "tieneTextoCompleto" => "en"
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "675"
          "paginaFinal" => "676"
        ]
      ]
      "titulosAlternativos" => array:1 [
        "es" => array:1 [
          "titulo" => "Condrodermatitis nodular del antih&#233;lix por tel&#233;fono m&#243;vil"
        ]
      ]
      "contieneTextoCompleto" => array:1 [
        "en" => true
      ]
      "contienePdf" => array:1 [
        "en" => true
      ]
      "resumenGrafico" => array:2 [
        "original" => 0
        "multimedia" => array:7 [
          "identificador" => "fig0005"
          "etiqueta" => "Figure 1"
          "tipo" => "MULTIMEDIAFIGURA"
          "mostrarFloat" => true
          "mostrarDisplay" => false
          "figura" => array:1 [
            0 => array:4 [
              "imagen" => "gr1.jpeg"
              "Alto" => 1221
              "Ancho" => 1628
              "Tamanyo" => 324909
            ]
          ]
          "descripcion" => array:1 [
            "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Ulcerated&#44; erythematous&#44; rounded&#44; nodular lesion with relatively well-defined borders on the antihelix&#46;</p>"
          ]
        ]
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "A&#46; Ortiz, P&#46; Mart&#237;n, J&#46; Dom&#237;nguez, J&#46; Conejo-Mir"
          "autores" => array:4 [
            0 => array:2 [
              "nombre" => "A&#46;"
              "apellidos" => "Ortiz"
            ]
            1 => array:2 [
              "nombre" => "P&#46;"
              "apellidos" => "Mart&#237;n"
            ]
            2 => array:2 [
              "nombre" => "J&#46;"
              "apellidos" => "Dom&#237;nguez"
            ]
            3 => array:2 [
              "nombre" => "J&#46;"
              "apellidos" => "Conejo-Mir"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "en"
    "Traduccion" => array:1 [
      "es" => array:9 [
        "pii" => "S0001731015001271"
        "doi" => "10.1016/j.ad.2015.01.014"
        "estado" => "S300"
        "subdocumento" => ""
        "abierto" => array:3 [
          "ES" => true
          "ES2" => true
          "LATM" => true
        ]
        "gratuito" => true
        "lecturas" => array:1 [
          "total" => 0
        ]
        "idiomaDefecto" => "es"
        "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0001731015001271?idApp=UINPBA000044"
      ]
    ]
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1578219015002012?idApp=UINPBA000044"
    "url" => "/15782190/0000010600000008/v1_201510011018/S1578219015002012/v1_201510011018/en/main.assets"
  ]
  "en" => array:15 [
    "idiomaDefecto" => true
    "cabecera" => "<span class="elsevierStyleTextfn">Case and Research Letters</span>"
    "titulo" => "Alopecia and Hirsutism in a Postmenopausal Woman as the Presenting Complaint of Ovarian Hilus &#40;Leydig&#41; Cell Tumor"
    "tieneTextoCompleto" => true
    "saludo" => "<span class="elsevierStyleItalic">To the Editor&#58;</span>"
    "paginas" => array:1 [
      0 => array:2 [
        "paginaInicial" => "676"
        "paginaFinal" => "678"
      ]
    ]
    "autores" => array:1 [
      0 => array:4 [
        "autoresLista" => "L&#46; Berbegal, M&#46;P&#46; Albares, F&#46;J&#46; De-Leon, G&#46; Negueruela"
        "autores" => array:4 [
          0 => array:4 [
            "nombre" => "L&#46;"
            "apellidos" => "Berbegal"
            "email" => array:1 [
              0 => "lauraberbegal&#64;gmail&#46;com"
            ]
            "referencia" => array:2 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">a</span>"
                "identificador" => "aff0005"
              ]
              1 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">&#42;</span>"
                "identificador" => "cor0005"
              ]
            ]
          ]
          1 => array:3 [
            "nombre" => "M&#46;P&#46;"
            "apellidos" => "Albares"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">a</span>"
                "identificador" => "aff0005"
              ]
            ]
          ]
          2 => array:3 [
            "nombre" => "F&#46;J&#46;"
            "apellidos" => "De-Leon"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">a</span>"
                "identificador" => "aff0005"
              ]
            ]
          ]
          3 => array:3 [
            "nombre" => "G&#46;"
            "apellidos" => "Negueruela"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">b</span>"
                "identificador" => "aff0010"
              ]
            ]
          ]
        ]
        "afiliaciones" => array:2 [
          0 => array:3 [
            "entidad" => "Servicio de Dermatolog&#237;a&#44; Hospital General Universitario de Alicante&#44; Alicante&#44; Spain"
            "etiqueta" => "a"
            "identificador" => "aff0005"
          ]
          1 => array:3 [
            "entidad" => "Servicio de Endocrinolog&#237;a&#44; Hospital General Universitario de Alicante&#44; Alicante&#44; Spain"
            "etiqueta" => "b"
            "identificador" => "aff0010"
          ]
        ]
        "correspondencia" => array:1 [
          0 => array:3 [
            "identificador" => "cor0005"
            "etiqueta" => "&#8270;"
            "correspondencia" => "Corresponding author&#46;"
          ]
        ]
      ]
    ]
    "titulosAlternativos" => array:1 [
      "es" => array:1 [
        "titulo" => "Alopecia e hirsutismo en una mujer posmenop&#225;usica como forma de presentaci&#243;n de un tumor de c&#233;lulas de Leydig hiliar del ovario"
      ]
    ]
    "resumenGrafico" => array:2 [
      "original" => 0
      "multimedia" => array:7 [
        "identificador" => "fig0005"
        "etiqueta" => "Figure 1"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr1.jpeg"
            "Alto" => 812
            "Ancho" => 2168
            "Tamanyo" => 330204
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">A&#44; Triangular-shaped frontoparietal hairline recession&#46; B&#44; Hair thinning on the crown&#46;</p>"
        ]
      ]
    ]
    "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">Female androgenetic alopecia is one of the main causes of hair loss&#44; and affects 50&#37; of women in their lifetime&#46;<a class="elsevierStyleCrossRef" href="#bib0050"><span class="elsevierStyleSup">1</span></a> Alopecia and hirsutism as a manifestation of hyperandrogenism in postmenopausal women can have various causes&#44; ranging from normal physiological changes to an ovarian or adrenal tumor&#46; Recommended tests in any woman presenting with alopecia are a detailed clinical history&#44; physical examination&#44; general blood tests &#40;including complete blood count and thyroid stimulating hormone and ferritin levels&#41; and a hormone study with measurement of dehydroepiandrosterone sulfate and total and free testosterone levels&#46;</p><p id="par0010" class="elsevierStylePara elsevierViewall">We present the case of a 65-year-old woman who presented with a 1-year history of hair loss and black facial hair&#46; There was no past history of alopecia&#44; hirsutism&#44; or hyperandrogenism&#46; Her history was remarkable for cardiovascular risk factors &#40;hypertension&#44; dyslipidemia&#44; and diabetes mellitus&#41;&#44; and she was also being monitored by the endocrinology department for euthyroid goiter&#46; The physical examination showed frontoparietal hair loss in a triangular-shaped pattern &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a> A&#41; and diffuse thinning on the crown &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a> B&#41;&#46; These findings were consistent with male-pattern female hair loss grade II in the Ebling classification system&#46; The patient also had hirsutism &#40;Ferriman-Gallwey score 9&#41;&#44; located predominantly on the face and sides of the neck but also in the chin area &#40;<a class="elsevierStyleCrossRef" href="#fig0010">Fig&#46; 2</a>&#41;&#46; Examination of the external genitalia revealed an enlarged clitoris&#46; There were no other signs of virilization&#44; such as voice deepening or increased muscle bulk&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><elsevierMultimedia ident="fig0010"></elsevierMultimedia><p id="par0015" class="elsevierStylePara elsevierViewall">Considering the physical findings&#44; we requested blood tests with complete blood count&#44; biochemistry&#44; erythrocyte sedimentation rate&#44; thyroid hormones&#44; and iron profile&#46; The results were all within normal ranges&#46; A hormone study showed hyperandrogenism&#44; with elevated testosterone levels &#40;4&#46;06<span class="elsevierStyleHsp" style=""></span>ng&#47;mL&#59; normal range&#44; 0&#46;20-0&#46;80<span class="elsevierStyleHsp" style=""></span>ng&#47;mL&#41;&#46; The tests also showed a level of 28<span class="elsevierStyleHsp" style=""></span>nmol&#47;L for sex hormone binding globulin &#40;normal range&#44; 11-124<span class="elsevierStyleHsp" style=""></span>nmol&#47;L&#41; and a free testosterone index of 45 &#40;normal range&#44; 1&#46;6-6&#41;&#46; Free testosterone is the biologically active fraction of testosterone&#46; Androstenedione&#44; dehydroepiandrosterone sulfate&#44; and 17-hydroxyprogesterone levels were all within normal limits&#46; Estradiol levels were high due to peripheral aromatization of testosterone&#46;</p><p id="par0020" class="elsevierStylePara elsevierViewall">The results suggested an ovarian tumor and we ordered a vaginal ultrasound&#44; which revealed no alterations&#46; The patient was referred to the endocrinology department for further testing&#44; including tumor marker and imaging tests&#46; Prolactin and cortisol tests were normal&#44; as were the results for all tumor markers analyzed except carcinoembryonic antigen&#44; with a level of 14&#46;5<span class="elsevierStyleHsp" style=""></span>ng&#47;mL &#40;normal range&#44; 0-5<span class="elsevierStyleHsp" style=""></span>ng&#47;mL&#41;&#46; An abdominal computed tomography scan showed images consistent with a left adrenal tumor &#40;<a class="elsevierStyleCrossRef" href="#fig0015">Fig&#46; 3</a>&#41;&#46; Magnetic resonance imaging of the pelvis showed no signs of an ovarian tumor&#46; With these findings&#44; it was decided to perform a left adrenalectomy&#44; but the patient continued to show high testosterone levels &#40;4&#46;06<span class="elsevierStyleHsp" style=""></span>ng&#47;mL&#59; normal range&#44; 0&#46;20-0&#46;80&#41; and a high free testosterone index &#40;42&#46;6&#59; normal range&#44; 1&#46;6-6&#41; after the operation&#46; Finally&#44; given the strong suspicion of hyperandrogenism of ovarian origin&#44; we performed a bilateral adnexectomy&#46;</p><elsevierMultimedia ident="fig0015"></elsevierMultimedia><p id="par0025" class="elsevierStylePara elsevierViewall">The histologic study confirmed a diagnosis of Leydig cell tumor&#44; hilar type&#44; in the right ovary&#46; At the time of writing&#44; 2 months after the adnexectomy&#44; the patient&#39;s testosterone levels have returned to normal and there are evident improvements in her hirsutism and alopecia&#46;</p><p id="par0030" class="elsevierStylePara elsevierViewall">Alopecia and hirsutism can be the presenting manifestation of a tumor&#44;<a class="elsevierStyleCrossRef" href="#bib0055"><span class="elsevierStyleSup">2</span></a> as shown by the case reported herein&#46; Hilar Leydig cell tumors of the ovary are very rare and account for just 0&#46;5&#37; of all ovarian tumors&#46; Accordingly&#44; very few cases have been described in the literature&#46; Although benign&#44; these tumors frequently cause virilization&#44; with increased androgen production&#44;<a class="elsevierStyleCrossRefs" href="#bib0060"><span class="elsevierStyleSup">3&#8211;5</span></a> and they are also associated with an increased risk of thromboembolism&#46;<a class="elsevierStyleCrossRef" href="#bib0075"><span class="elsevierStyleSup">6</span></a> Leydig tumor cells in the ovary can be very small and may go undetected in imaging studies&#46; This is why adnexectomy is frequently performed as part of a diagnosis of exclusion&#46;<a class="elsevierStyleCrossRef" href="#bib0080"><span class="elsevierStyleSup">7</span></a> Adnexectomy of just the affected ovary is an option in premenopausal women&#46; The ovary to be removed is identified during surgery by measuring testosterone levels in the ovarian veins&#46;<a class="elsevierStyleCrossRef" href="#bib0085"><span class="elsevierStyleSup">8</span></a></p><p id="par0035" class="elsevierStylePara elsevierViewall">Hyperandrogenism&#44; particularly with signs of virilization&#44; is very uncommon in postmenopausal women and tends to be due to tumors &#40;mainly of ovarian or adrenal origin&#41;&#46;<a class="elsevierStyleCrossRef" href="#bib0090"><span class="elsevierStyleSup">9</span></a> Other causes that should be ruled out&#44; however&#44; are drugs&#44; pituitary disorders&#44; and the ectopic production of hormones by tumors&#46; The severity of the hyperandrogenism&#44; the patient&#39;s age&#44; and the speed with which signs and symptoms appear are all important diagnostic clues&#46;</p></span>"
    "pdfFichero" => "main.pdf"
    "tienePdf" => true
    "NotaPie" => array:1 [
      0 => array:2 [
        "etiqueta" => "&#9734;"
        "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Please cite this article as&#58; Berbegal L&#44; Albares MP&#44; De-Leon FJ&#44; Negueruela G&#46; Alopecia e hirsutismo en una mujer posmenop&#225;usica como forma de presentaci&#243;n de un tumor de c&#233;lulas de Leydig hiliar del ovario&#46; Actas Dermosifiliogr&#46; 2015&#59;106&#58;676&#8211;678&#46;</p>"
      ]
    ]
    "multimedia" => array:3 [
      0 => array:7 [
        "identificador" => "fig0005"
        "etiqueta" => "Figure 1"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr1.jpeg"
            "Alto" => 812
            "Ancho" => 2168
            "Tamanyo" => 330204
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">A&#44; Triangular-shaped frontoparietal hairline recession&#46; B&#44; Hair thinning on the crown&#46;</p>"
        ]
      ]
      1 => array:7 [
        "identificador" => "fig0010"
        "etiqueta" => "Figure 2"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr2.jpeg"
            "Alto" => 1171
            "Ancho" => 1660
            "Tamanyo" => 375421
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Hirsutism affecting the chin and sides of the face and neck&#46;</p>"
        ]
      ]
      2 => array:7 [
        "identificador" => "fig0015"
        "etiqueta" => "Figure 3"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr3.jpeg"
            "Alto" => 1868
            "Ancho" => 1626
            "Tamanyo" => 296322
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Left adrenal nodule measuring 2&#46;6<span class="elsevierStyleHsp" style=""></span>cm&#46;</p>"
        ]
      ]
    ]
    "bibliografia" => array:2 [
      "titulo" => "References"
      "seccion" => array:1 [
        0 => array:2 [
          "identificador" => "bibs0005"
          "bibliografiaReferencia" => array:9 [
            0 => array:3 [
              "identificador" => "bib0050"
              "etiqueta" => "1"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Manejo de las mujeres posmenop&#225;usicas en la alopecia androgen&#233;tica"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "R&#46; Rivera"
                            1 => "A&#46; Guerra-Tapia"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Actas Dermosifiliogr"
                        "fecha" => "2008"
                        "volumen" => "99"
                        "paginaInicial" => "257"
                        "paginaFinal" => "261"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18394400"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            1 => array:3 [
              "identificador" => "bib0055"
              "etiqueta" => "2"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Alertas cut&#225;neas en malignidades sist&#233;micas"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "M&#46; Yuste"
                            1 => "P&#46; Unamuno"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.adengl.2012.05.026"
                      "Revista" => array:6 [
                        "tituloSerie" => "Actas Dermosifiliogr"
                        "fecha" => "2013"
                        "volumen" => "104"
                        "paginaInicial" => "543"
                        "paginaFinal" => "553"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/23891448"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            2 => array:3 [
              "identificador" => "bib0060"
              "etiqueta" => "3"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Pure Leydig cell tumour &#40;hilus cell&#41; of the ovary&#58; A rare cause of virilization after menopause"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "G&#46; Bajocchi"
                            1 => "N&#46; Manci"
                            2 => "G&#46; Angeletti"
                            3 => "R&#46; Celleno"
                            4 => "D&#46; Fratini"
                            5 => "G&#46; Gilardi"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Gynecol Obstet Invest"
                        "fecha" => "1997"
                        "volumen" => "44"
                        "paginaInicial" => "141"
                        "paginaFinal" => "144"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9286731"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            3 => array:3 [
              "identificador" => "bib0065"
              "etiqueta" => "4"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Leydig cell tumor of the ovary postmenopausal woman presenting with virilization"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "I&#46; Bancos"
                            1 => "H&#46; Prawius"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "The Endocrinologist"
                        "fecha" => "2008"
                        "volumen" => "18"
                        "paginaInicial" => "146"
                        "paginaFinal" => "149"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            4 => array:3 [
              "identificador" => "bib0070"
              "etiqueta" => "5"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Bilateral Leydig cell tumour of the ovary&#58; A rare cause of virilization in postmenopausal patient"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "O&#46;A&#46; Sanz"
                            1 => "P&#46;R&#46; Martinez"
                            2 => "R&#46;T&#46; Guarch"
                            3 => "M&#46;J&#46; Go&#241;i"
                            4 => "J&#46;L&#46; Alcazar"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.maturitas.2006.11.013"
                      "Revista" => array:6 [
                        "tituloSerie" => "Maturitas"
                        "fecha" => "2007"
                        "volumen" => "57"
                        "paginaInicial" => "214"
                        "paginaFinal" => "216"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17289310"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            5 => array:3 [
              "identificador" => "bib0075"
              "etiqueta" => "6"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "A Leydig cell tumor of the ovary resulting in extreme hyperandrogenism&#44; erythrocytosis&#44; and recurrent pulmonar embolism"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "P&#46; Kozan"
                            1 => "S&#46; Chalasani"
                            2 => "D&#46;J&#46; Handelsman"
                            3 => "A&#46;H&#46; Pike"
                            4 => "B&#46;A&#46; Crawford"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1210/jc.2013-3108"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Clin Endocrinol Metab"
                        "fecha" => "2014"
                        "volumen" => "99"
                        "paginaInicial" => "12"
                        "paginaFinal" => "17"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/24152686"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            6 => array:3 [
              "identificador" => "bib0080"
              "etiqueta" => "7"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "A rare case of hyperandrogenism&#58; Bilateral Leydig cell tumor of the ovary"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "M&#46; Marcelino"
                            1 => "E&#46; Nobre"
                            2 => "J&#46; Concei&#231;&#227;o"
                            3 => "L&#46; Lopes"
                            4 => "H&#46; Vilar"
                            5 => "M&#46; Fran&#231;a Martins"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Acta Med Port"
                        "fecha" => "2010"
                        "volumen" => "23"
                        "paginaInicial" => "113"
                        "paginaFinal" => "118"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/20353714"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            7 => array:3 [
              "identificador" => "bib0085"
              "etiqueta" => "8"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Intraoperative testosterone assay for virilizing ovarian tumor topographic assessment&#58; Report of a Leydig cell tumor of the ovary in a premenopausal woman with an adrenal incidentaloma"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "C&#46; Regnier"
                            1 => "A&#46; Bennet"
                            2 => "D&#46; Malet"
                            3 => "T&#46; Guez"
                            4 => "M&#46; Plantavid"
                            5 => "P&#46; Rochaix"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "J Clin EndocrinolMetab"
                        "fecha" => "2002"
                        "volumen" => "87"
                        "paginaInicial" => "3074"
                        "paginaFinal" => "3077"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            8 => array:3 [
              "identificador" => "bib0090"
              "etiqueta" => "9"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Hiperandrogenismo avanzado en una mujer posmenop&#225;usica&#46; Caso cl&#237;nico"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "P&#46; Salman"
                            1 => "M&#46; Cuello"
                            2 => "M&#46; Kolbach"
                            3 => "R&#46; Gejman"
                            4 => "E&#46; Arteaga"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "/S0034-98872011000800013"
                      "Revista" => array:6 [
                        "tituloSerie" => "Rev Med Chile"
                        "fecha" => "2011"
                        "volumen" => "139"
                        "paginaInicial" => "1066"
                        "paginaFinal" => "1070"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/22215338"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
          ]
        ]
      ]
    ]
  ]
  "idiomaDefecto" => "en"
  "url" => "/15782190/0000010600000008/v1_201510011018/S1578219015002024/v1_201510011018/en/main.assets"
  "Apartado" => array:4 [
    "identificador" => "6157"
    "tipo" => "SECCION"
    "en" => array:2 [
      "titulo" => "Case and Research Letters"
      "idiomaDefecto" => true
    ]
    "idiomaDefecto" => "en"
  ]
  "PDF" => "https://static.elsevier.es/multimedia/15782190/0000010600000008/v1_201510011018/S1578219015002024/v1_201510011018/en/main.pdf?idApp=UINPBA000044&text.app=https://actasdermo.org/"
  "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1578219015002024?idApp=UINPBA000044"
]
Compartir
Información de la revista

Estadísticas

Siga este enlace para acceder al texto completo del artículo

Case and Research Letters
Alopecia and Hirsutism in a Postmenopausal Woman as the Presenting Complaint of Ovarian Hilus (Leydig) Cell Tumor
Alopecia e hirsutismo en una mujer posmenopáusica como forma de presentación de un tumor de células de Leydig hiliar del ovario
L. Berbegala,
Autor para correspondencia
lauraberbegal@gmail.com

Corresponding author.
, M.P. Albaresa, F.J. De-Leona, G. Negueruelab
a Servicio de Dermatología, Hospital General Universitario de Alicante, Alicante, Spain
b Servicio de Endocrinología, Hospital General Universitario de Alicante, Alicante, Spain
Leído
6778
Veces
se ha leído el artículo
2178
Total PDF
4600
Total HTML
Compartir estadísticas
 array:24 [
  "pii" => "S1578219015002024"
  "issn" => "15782190"
  "doi" => "10.1016/j.adengl.2015.07.004"
  "estado" => "S300"
  "fechaPublicacion" => "2015-10-01"
  "aid" => "1145"
  "copyright" => "Elsevier Espa&#241;a&#44; S&#46;L&#46;U&#46; and AEDV"
  "copyrightAnyo" => "2014"
  "documento" => "simple-article"
  "crossmark" => 1
  "subdocumento" => "cor"
  "cita" => "Actas Dermosifiliogr. 2015;106:676-8"
  "abierto" => array:3 [
    "ES" => true
    "ES2" => true
    "LATM" => true
  ]
  "gratuito" => true
  "lecturas" => array:2 [
    "total" => 908
    "formatos" => array:3 [
      "EPUB" => 48
      "HTML" => 479
      "PDF" => 381
    ]
  ]
  "Traduccion" => array:1 [
    "es" => array:19 [
      "pii" => "S0001731015001295"
      "issn" => "00017310"
      "doi" => "10.1016/j.ad.2014.12.022"
      "estado" => "S300"
      "fechaPublicacion" => "2015-10-01"
      "aid" => "1145"
      "copyright" => "Elsevier Espa&#241;a&#44; S&#46;L&#46;U&#46; y AEDV"
      "documento" => "simple-article"
      "crossmark" => 1
      "subdocumento" => "crp"
      "cita" => "Actas Dermosifiliogr. 2015;106:676-8"
      "abierto" => array:3 [
        "ES" => true
        "ES2" => true
        "LATM" => true
      ]
      "gratuito" => true
      "lecturas" => array:2 [
        "total" => 744
        "formatos" => array:3 [
          "EPUB" => 2
          "HTML" => 378
          "PDF" => 364
        ]
      ]
      "es" => array:11 [
        "idiomaDefecto" => true
        "cabecera" => "<span class="elsevierStyleTextfn">Carta cient&#237;fico-cl&#237;nica</span>"
        "titulo" => "Alopecia e hirsutismo en una mujer posmenop&#225;usica como forma de presentaci&#243;n de un tumor de c&#233;lulas de Leydig hiliar del ovario"
        "tienePdf" => "es"
        "tieneTextoCompleto" => "es"
        "paginas" => array:1 [
          0 => array:2 [
            "paginaInicial" => "676"
            "paginaFinal" => "678"
          ]
        ]
        "titulosAlternativos" => array:1 [
          "en" => array:1 [
            "titulo" => "Alopecia and Hirsutism in a Postmenopausal Woman as the Presenting Complaint of Ovarian Hilus &#40;Leydig&#41; Cell Tumor"
          ]
        ]
        "contieneTextoCompleto" => array:1 [
          "es" => true
        ]
        "contienePdf" => array:1 [
          "es" => true
        ]
        "resumenGrafico" => array:2 [
          "original" => 0
          "multimedia" => array:7 [
            "identificador" => "fig0015"
            "etiqueta" => "Figura 3"
            "tipo" => "MULTIMEDIAFIGURA"
            "mostrarFloat" => true
            "mostrarDisplay" => false
            "figura" => array:1 [
              0 => array:4 [
                "imagen" => "gr3.jpeg"
                "Alto" => 1120
                "Ancho" => 975
                "Tamanyo" => 161737
              ]
            ]
            "descripcion" => array:1 [
              "es" => "<p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">N&#243;dulo suprarrenal izquierdo de 2&#44;6<span class="elsevierStyleHsp" style=""></span>cm&#46;</p>"
            ]
          ]
        ]
        "autores" => array:1 [
          0 => array:2 [
            "autoresLista" => "L&#46; Berbegal, M&#46;P&#46; Albares, F&#46;J&#46; De-Leon, G&#46; Negueruela"
            "autores" => array:4 [
              0 => array:2 [
                "nombre" => "L&#46;"
                "apellidos" => "Berbegal"
              ]
              1 => array:2 [
                "nombre" => "M&#46;P&#46;"
                "apellidos" => "Albares"
              ]
              2 => array:2 [
                "nombre" => "F&#46;J&#46;"
                "apellidos" => "De-Leon"
              ]
              3 => array:2 [
                "nombre" => "G&#46;"
                "apellidos" => "Negueruela"
              ]
            ]
          ]
        ]
      ]
      "idiomaDefecto" => "es"
      "Traduccion" => array:1 [
        "en" => array:9 [
          "pii" => "S1578219015002024"
          "doi" => "10.1016/j.adengl.2015.07.004"
          "estado" => "S300"
          "subdocumento" => ""
          "abierto" => array:3 [
            "ES" => true
            "ES2" => true
            "LATM" => true
          ]
          "gratuito" => true
          "lecturas" => array:1 [
            "total" => 0
          ]
          "idiomaDefecto" => "en"
          "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1578219015002024?idApp=UINPBA000044"
        ]
      ]
      "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0001731015001295?idApp=UINPBA000044"
      "url" => "/00017310/0000010600000008/v1_201510020746/S0001731015001295/v1_201510020746/es/main.assets"
    ]
  ]
  "itemSiguiente" => array:19 [
    "pii" => "S1578219015002036"
    "issn" => "15782190"
    "doi" => "10.1016/j.adengl.2015.07.005"
    "estado" => "S300"
    "fechaPublicacion" => "2015-10-01"
    "aid" => "1146"
    "copyright" => "Elsevier Espa&#241;a&#44; S&#46;L&#46;U&#46; and AEDV"
    "documento" => "simple-article"
    "crossmark" => 1
    "subdocumento" => "cor"
    "cita" => "Actas Dermosifiliogr. 2015;106:678-80"
    "abierto" => array:3 [
      "ES" => true
      "ES2" => true
      "LATM" => true
    ]
    "gratuito" => true
    "lecturas" => array:2 [
      "total" => 880
      "formatos" => array:3 [
        "EPUB" => 44
        "HTML" => 547
        "PDF" => 289
      ]
    ]
    "en" => array:11 [
      "idiomaDefecto" => true
      "cabecera" => "<span class="elsevierStyleTextfn">Case and Research Letters</span>"
      "titulo" => "Diagnostic Value of Color Doppler Ultrasound for Cutaneous Odontogenic Sinus Tract"
      "tienePdf" => "en"
      "tieneTextoCompleto" => "en"
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "678"
          "paginaFinal" => "680"
        ]
      ]
      "titulosAlternativos" => array:1 [
        "es" => array:1 [
          "titulo" => "Utilidad de la ecograf&#237;a doppler color para el diagn&#243;stico de f&#237;stulas dentocut&#225;neas"
        ]
      ]
      "contieneTextoCompleto" => array:1 [
        "en" => true
      ]
      "contienePdf" => array:1 [
        "en" => true
      ]
      "resumenGrafico" => array:2 [
        "original" => 0
        "multimedia" => array:7 [
          "identificador" => "fig0005"
          "etiqueta" => "Figure 1"
          "tipo" => "MULTIMEDIAFIGURA"
          "mostrarFloat" => true
          "mostrarDisplay" => false
          "figura" => array:1 [
            0 => array:4 [
              "imagen" => "gr1.jpeg"
              "Alto" => 1667
              "Ancho" => 1251
              "Tamanyo" => 381212
            ]
          ]
          "descripcion" => array:1 [
            "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Cutaneous horn sunken into the skin over the left horizontal ramus of the mandible&#46;</p>"
          ]
        ]
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "C&#46; Garrido Colmenero, G&#46; Blasco Morente, J&#46;M&#46; Latorre Fuentes, R&#46; Ruiz Villaverde"
          "autores" => array:4 [
            0 => array:2 [
              "nombre" => "C&#46;"
              "apellidos" => "Garrido Colmenero"
            ]
            1 => array:2 [
              "nombre" => "G&#46;"
              "apellidos" => "Blasco Morente"
            ]
            2 => array:2 [
              "nombre" => "J&#46;M&#46;"
              "apellidos" => "Latorre Fuentes"
            ]
            3 => array:2 [
              "nombre" => "R&#46;"
              "apellidos" => "Ruiz Villaverde"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "en"
    "Traduccion" => array:1 [
      "es" => array:9 [
        "pii" => "S0001731015001301"
        "doi" => "10.1016/j.ad.2014.12.023"
        "estado" => "S300"
        "subdocumento" => ""
        "abierto" => array:3 [
          "ES" => true
          "ES2" => true
          "LATM" => true
        ]
        "gratuito" => true
        "lecturas" => array:1 [
          "total" => 0
        ]
        "idiomaDefecto" => "es"
        "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0001731015001301?idApp=UINPBA000044"
      ]
    ]
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1578219015002036?idApp=UINPBA000044"
    "url" => "/15782190/0000010600000008/v1_201510011018/S1578219015002036/v1_201510011018/en/main.assets"
  ]
  "itemAnterior" => array:19 [
    "pii" => "S1578219015002012"
    "issn" => "15782190"
    "doi" => "10.1016/j.adengl.2015.07.003"
    "estado" => "S300"
    "fechaPublicacion" => "2015-10-01"
    "aid" => "1143"
    "copyright" => "Elsevier Espa&#241;a&#44; S&#46;L&#46;U&#46; and AEDV"
    "documento" => "simple-article"
    "crossmark" => 1
    "subdocumento" => "cor"
    "cita" => "Actas Dermosifiliogr. 2015;106:675-6"
    "abierto" => array:3 [
      "ES" => true
      "ES2" => true
      "LATM" => true
    ]
    "gratuito" => true
    "lecturas" => array:2 [
      "total" => 976
      "formatos" => array:3 [
        "EPUB" => 41
        "HTML" => 558
        "PDF" => 377
      ]
    ]
    "en" => array:11 [
      "idiomaDefecto" => true
      "cabecera" => "<span class="elsevierStyleTextfn">Case and Research Letters</span>"
      "titulo" => "Cell Phone-Induced Chondrodermatitis Nodularis Antihelicis"
      "tienePdf" => "en"
      "tieneTextoCompleto" => "en"
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "675"
          "paginaFinal" => "676"
        ]
      ]
      "titulosAlternativos" => array:1 [
        "es" => array:1 [
          "titulo" => "Condrodermatitis nodular del antih&#233;lix por tel&#233;fono m&#243;vil"
        ]
      ]
      "contieneTextoCompleto" => array:1 [
        "en" => true
      ]
      "contienePdf" => array:1 [
        "en" => true
      ]
      "resumenGrafico" => array:2 [
        "original" => 0
        "multimedia" => array:7 [
          "identificador" => "fig0005"
          "etiqueta" => "Figure 1"
          "tipo" => "MULTIMEDIAFIGURA"
          "mostrarFloat" => true
          "mostrarDisplay" => false
          "figura" => array:1 [
            0 => array:4 [
              "imagen" => "gr1.jpeg"
              "Alto" => 1221
              "Ancho" => 1628
              "Tamanyo" => 324909
            ]
          ]
          "descripcion" => array:1 [
            "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Ulcerated&#44; erythematous&#44; rounded&#44; nodular lesion with relatively well-defined borders on the antihelix&#46;</p>"
          ]
        ]
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "A&#46; Ortiz, P&#46; Mart&#237;n, J&#46; Dom&#237;nguez, J&#46; Conejo-Mir"
          "autores" => array:4 [
            0 => array:2 [
              "nombre" => "A&#46;"
              "apellidos" => "Ortiz"
            ]
            1 => array:2 [
              "nombre" => "P&#46;"
              "apellidos" => "Mart&#237;n"
            ]
            2 => array:2 [
              "nombre" => "J&#46;"
              "apellidos" => "Dom&#237;nguez"
            ]
            3 => array:2 [
              "nombre" => "J&#46;"
              "apellidos" => "Conejo-Mir"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "en"
    "Traduccion" => array:1 [
      "es" => array:9 [
        "pii" => "S0001731015001271"
        "doi" => "10.1016/j.ad.2015.01.014"
        "estado" => "S300"
        "subdocumento" => ""
        "abierto" => array:3 [
          "ES" => true
          "ES2" => true
          "LATM" => true
        ]
        "gratuito" => true
        "lecturas" => array:1 [
          "total" => 0
        ]
        "idiomaDefecto" => "es"
        "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0001731015001271?idApp=UINPBA000044"
      ]
    ]
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1578219015002012?idApp=UINPBA000044"
    "url" => "/15782190/0000010600000008/v1_201510011018/S1578219015002012/v1_201510011018/en/main.assets"
  ]
  "en" => array:15 [
    "idiomaDefecto" => true
    "cabecera" => "<span class="elsevierStyleTextfn">Case and Research Letters</span>"
    "titulo" => "Alopecia and Hirsutism in a Postmenopausal Woman as the Presenting Complaint of Ovarian Hilus &#40;Leydig&#41; Cell Tumor"
    "tieneTextoCompleto" => true
    "saludo" => "<span class="elsevierStyleItalic">To the Editor&#58;</span>"
    "paginas" => array:1 [
      0 => array:2 [
        "paginaInicial" => "676"
        "paginaFinal" => "678"
      ]
    ]
    "autores" => array:1 [
      0 => array:4 [
        "autoresLista" => "L&#46; Berbegal, M&#46;P&#46; Albares, F&#46;J&#46; De-Leon, G&#46; Negueruela"
        "autores" => array:4 [
          0 => array:4 [
            "nombre" => "L&#46;"
            "apellidos" => "Berbegal"
            "email" => array:1 [
              0 => "lauraberbegal&#64;gmail&#46;com"
            ]
            "referencia" => array:2 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">a</span>"
                "identificador" => "aff0005"
              ]
              1 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">&#42;</span>"
                "identificador" => "cor0005"
              ]
            ]
          ]
          1 => array:3 [
            "nombre" => "M&#46;P&#46;"
            "apellidos" => "Albares"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">a</span>"
                "identificador" => "aff0005"
              ]
            ]
          ]
          2 => array:3 [
            "nombre" => "F&#46;J&#46;"
            "apellidos" => "De-Leon"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">a</span>"
                "identificador" => "aff0005"
              ]
            ]
          ]
          3 => array:3 [
            "nombre" => "G&#46;"
            "apellidos" => "Negueruela"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">b</span>"
                "identificador" => "aff0010"
              ]
            ]
          ]
        ]
        "afiliaciones" => array:2 [
          0 => array:3 [
            "entidad" => "Servicio de Dermatolog&#237;a&#44; Hospital General Universitario de Alicante&#44; Alicante&#44; Spain"
            "etiqueta" => "a"
            "identificador" => "aff0005"
          ]
          1 => array:3 [
            "entidad" => "Servicio de Endocrinolog&#237;a&#44; Hospital General Universitario de Alicante&#44; Alicante&#44; Spain"
            "etiqueta" => "b"
            "identificador" => "aff0010"
          ]
        ]
        "correspondencia" => array:1 [
          0 => array:3 [
            "identificador" => "cor0005"
            "etiqueta" => "&#8270;"
            "correspondencia" => "Corresponding author&#46;"
          ]
        ]
      ]
    ]
    "titulosAlternativos" => array:1 [
      "es" => array:1 [
        "titulo" => "Alopecia e hirsutismo en una mujer posmenop&#225;usica como forma de presentaci&#243;n de un tumor de c&#233;lulas de Leydig hiliar del ovario"
      ]
    ]
    "resumenGrafico" => array:2 [
      "original" => 0
      "multimedia" => array:7 [
        "identificador" => "fig0005"
        "etiqueta" => "Figure 1"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr1.jpeg"
            "Alto" => 812
            "Ancho" => 2168
            "Tamanyo" => 330204
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">A&#44; Triangular-shaped frontoparietal hairline recession&#46; B&#44; Hair thinning on the crown&#46;</p>"
        ]
      ]
    ]
    "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">Female androgenetic alopecia is one of the main causes of hair loss&#44; and affects 50&#37; of women in their lifetime&#46;<a class="elsevierStyleCrossRef" href="#bib0050"><span class="elsevierStyleSup">1</span></a> Alopecia and hirsutism as a manifestation of hyperandrogenism in postmenopausal women can have various causes&#44; ranging from normal physiological changes to an ovarian or adrenal tumor&#46; Recommended tests in any woman presenting with alopecia are a detailed clinical history&#44; physical examination&#44; general blood tests &#40;including complete blood count and thyroid stimulating hormone and ferritin levels&#41; and a hormone study with measurement of dehydroepiandrosterone sulfate and total and free testosterone levels&#46;</p><p id="par0010" class="elsevierStylePara elsevierViewall">We present the case of a 65-year-old woman who presented with a 1-year history of hair loss and black facial hair&#46; There was no past history of alopecia&#44; hirsutism&#44; or hyperandrogenism&#46; Her history was remarkable for cardiovascular risk factors &#40;hypertension&#44; dyslipidemia&#44; and diabetes mellitus&#41;&#44; and she was also being monitored by the endocrinology department for euthyroid goiter&#46; The physical examination showed frontoparietal hair loss in a triangular-shaped pattern &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a> A&#41; and diffuse thinning on the crown &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a> B&#41;&#46; These findings were consistent with male-pattern female hair loss grade II in the Ebling classification system&#46; The patient also had hirsutism &#40;Ferriman-Gallwey score 9&#41;&#44; located predominantly on the face and sides of the neck but also in the chin area &#40;<a class="elsevierStyleCrossRef" href="#fig0010">Fig&#46; 2</a>&#41;&#46; Examination of the external genitalia revealed an enlarged clitoris&#46; There were no other signs of virilization&#44; such as voice deepening or increased muscle bulk&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><elsevierMultimedia ident="fig0010"></elsevierMultimedia><p id="par0015" class="elsevierStylePara elsevierViewall">Considering the physical findings&#44; we requested blood tests with complete blood count&#44; biochemistry&#44; erythrocyte sedimentation rate&#44; thyroid hormones&#44; and iron profile&#46; The results were all within normal ranges&#46; A hormone study showed hyperandrogenism&#44; with elevated testosterone levels &#40;4&#46;06<span class="elsevierStyleHsp" style=""></span>ng&#47;mL&#59; normal range&#44; 0&#46;20-0&#46;80<span class="elsevierStyleHsp" style=""></span>ng&#47;mL&#41;&#46; The tests also showed a level of 28<span class="elsevierStyleHsp" style=""></span>nmol&#47;L for sex hormone binding globulin &#40;normal range&#44; 11-124<span class="elsevierStyleHsp" style=""></span>nmol&#47;L&#41; and a free testosterone index of 45 &#40;normal range&#44; 1&#46;6-6&#41;&#46; Free testosterone is the biologically active fraction of testosterone&#46; Androstenedione&#44; dehydroepiandrosterone sulfate&#44; and 17-hydroxyprogesterone levels were all within normal limits&#46; Estradiol levels were high due to peripheral aromatization of testosterone&#46;</p><p id="par0020" class="elsevierStylePara elsevierViewall">The results suggested an ovarian tumor and we ordered a vaginal ultrasound&#44; which revealed no alterations&#46; The patient was referred to the endocrinology department for further testing&#44; including tumor marker and imaging tests&#46; Prolactin and cortisol tests were normal&#44; as were the results for all tumor markers analyzed except carcinoembryonic antigen&#44; with a level of 14&#46;5<span class="elsevierStyleHsp" style=""></span>ng&#47;mL &#40;normal range&#44; 0-5<span class="elsevierStyleHsp" style=""></span>ng&#47;mL&#41;&#46; An abdominal computed tomography scan showed images consistent with a left adrenal tumor &#40;<a class="elsevierStyleCrossRef" href="#fig0015">Fig&#46; 3</a>&#41;&#46; Magnetic resonance imaging of the pelvis showed no signs of an ovarian tumor&#46; With these findings&#44; it was decided to perform a left adrenalectomy&#44; but the patient continued to show high testosterone levels &#40;4&#46;06<span class="elsevierStyleHsp" style=""></span>ng&#47;mL&#59; normal range&#44; 0&#46;20-0&#46;80&#41; and a high free testosterone index &#40;42&#46;6&#59; normal range&#44; 1&#46;6-6&#41; after the operation&#46; Finally&#44; given the strong suspicion of hyperandrogenism of ovarian origin&#44; we performed a bilateral adnexectomy&#46;</p><elsevierMultimedia ident="fig0015"></elsevierMultimedia><p id="par0025" class="elsevierStylePara elsevierViewall">The histologic study confirmed a diagnosis of Leydig cell tumor&#44; hilar type&#44; in the right ovary&#46; At the time of writing&#44; 2 months after the adnexectomy&#44; the patient&#39;s testosterone levels have returned to normal and there are evident improvements in her hirsutism and alopecia&#46;</p><p id="par0030" class="elsevierStylePara elsevierViewall">Alopecia and hirsutism can be the presenting manifestation of a tumor&#44;<a class="elsevierStyleCrossRef" href="#bib0055"><span class="elsevierStyleSup">2</span></a> as shown by the case reported herein&#46; Hilar Leydig cell tumors of the ovary are very rare and account for just 0&#46;5&#37; of all ovarian tumors&#46; Accordingly&#44; very few cases have been described in the literature&#46; Although benign&#44; these tumors frequently cause virilization&#44; with increased androgen production&#44;<a class="elsevierStyleCrossRefs" href="#bib0060"><span class="elsevierStyleSup">3&#8211;5</span></a> and they are also associated with an increased risk of thromboembolism&#46;<a class="elsevierStyleCrossRef" href="#bib0075"><span class="elsevierStyleSup">6</span></a> Leydig tumor cells in the ovary can be very small and may go undetected in imaging studies&#46; This is why adnexectomy is frequently performed as part of a diagnosis of exclusion&#46;<a class="elsevierStyleCrossRef" href="#bib0080"><span class="elsevierStyleSup">7</span></a> Adnexectomy of just the affected ovary is an option in premenopausal women&#46; The ovary to be removed is identified during surgery by measuring testosterone levels in the ovarian veins&#46;<a class="elsevierStyleCrossRef" href="#bib0085"><span class="elsevierStyleSup">8</span></a></p><p id="par0035" class="elsevierStylePara elsevierViewall">Hyperandrogenism&#44; particularly with signs of virilization&#44; is very uncommon in postmenopausal women and tends to be due to tumors &#40;mainly of ovarian or adrenal origin&#41;&#46;<a class="elsevierStyleCrossRef" href="#bib0090"><span class="elsevierStyleSup">9</span></a> Other causes that should be ruled out&#44; however&#44; are drugs&#44; pituitary disorders&#44; and the ectopic production of hormones by tumors&#46; The severity of the hyperandrogenism&#44; the patient&#39;s age&#44; and the speed with which signs and symptoms appear are all important diagnostic clues&#46;</p></span>"
    "pdfFichero" => "main.pdf"
    "tienePdf" => true
    "NotaPie" => array:1 [
      0 => array:2 [
        "etiqueta" => "&#9734;"
        "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Please cite this article as&#58; Berbegal L&#44; Albares MP&#44; De-Leon FJ&#44; Negueruela G&#46; Alopecia e hirsutismo en una mujer posmenop&#225;usica como forma de presentaci&#243;n de un tumor de c&#233;lulas de Leydig hiliar del ovario&#46; Actas Dermosifiliogr&#46; 2015&#59;106&#58;676&#8211;678&#46;</p>"
      ]
    ]
    "multimedia" => array:3 [
      0 => array:7 [
        "identificador" => "fig0005"
        "etiqueta" => "Figure 1"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr1.jpeg"
            "Alto" => 812
            "Ancho" => 2168
            "Tamanyo" => 330204
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">A&#44; Triangular-shaped frontoparietal hairline recession&#46; B&#44; Hair thinning on the crown&#46;</p>"
        ]
      ]
      1 => array:7 [
        "identificador" => "fig0010"
        "etiqueta" => "Figure 2"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr2.jpeg"
            "Alto" => 1171
            "Ancho" => 1660
            "Tamanyo" => 375421
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Hirsutism affecting the chin and sides of the face and neck&#46;</p>"
        ]
      ]
      2 => array:7 [
        "identificador" => "fig0015"
        "etiqueta" => "Figure 3"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr3.jpeg"
            "Alto" => 1868
            "Ancho" => 1626
            "Tamanyo" => 296322
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Left adrenal nodule measuring 2&#46;6<span class="elsevierStyleHsp" style=""></span>cm&#46;</p>"
        ]
      ]
    ]
    "bibliografia" => array:2 [
      "titulo" => "References"
      "seccion" => array:1 [
        0 => array:2 [
          "identificador" => "bibs0005"
          "bibliografiaReferencia" => array:9 [
            0 => array:3 [
              "identificador" => "bib0050"
              "etiqueta" => "1"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Manejo de las mujeres posmenop&#225;usicas en la alopecia androgen&#233;tica"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "R&#46; Rivera"
                            1 => "A&#46; Guerra-Tapia"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Actas Dermosifiliogr"
                        "fecha" => "2008"
                        "volumen" => "99"
                        "paginaInicial" => "257"
                        "paginaFinal" => "261"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18394400"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            1 => array:3 [
              "identificador" => "bib0055"
              "etiqueta" => "2"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Alertas cut&#225;neas en malignidades sist&#233;micas"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "M&#46; Yuste"
                            1 => "P&#46; Unamuno"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.adengl.2012.05.026"
                      "Revista" => array:6 [
                        "tituloSerie" => "Actas Dermosifiliogr"
                        "fecha" => "2013"
                        "volumen" => "104"
                        "paginaInicial" => "543"
                        "paginaFinal" => "553"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/23891448"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            2 => array:3 [
              "identificador" => "bib0060"
              "etiqueta" => "3"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Pure Leydig cell tumour &#40;hilus cell&#41; of the ovary&#58; A rare cause of virilization after menopause"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "G&#46; Bajocchi"
                            1 => "N&#46; Manci"
                            2 => "G&#46; Angeletti"
                            3 => "R&#46; Celleno"
                            4 => "D&#46; Fratini"
                            5 => "G&#46; Gilardi"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Gynecol Obstet Invest"
                        "fecha" => "1997"
                        "volumen" => "44"
                        "paginaInicial" => "141"
                        "paginaFinal" => "144"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9286731"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            3 => array:3 [
              "identificador" => "bib0065"
              "etiqueta" => "4"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Leydig cell tumor of the ovary postmenopausal woman presenting with virilization"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "I&#46; Bancos"
                            1 => "H&#46; Prawius"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "The Endocrinologist"
                        "fecha" => "2008"
                        "volumen" => "18"
                        "paginaInicial" => "146"
                        "paginaFinal" => "149"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            4 => array:3 [
              "identificador" => "bib0070"
              "etiqueta" => "5"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Bilateral Leydig cell tumour of the ovary&#58; A rare cause of virilization in postmenopausal patient"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "O&#46;A&#46; Sanz"
                            1 => "P&#46;R&#46; Martinez"
                            2 => "R&#46;T&#46; Guarch"
                            3 => "M&#46;J&#46; Go&#241;i"
                            4 => "J&#46;L&#46; Alcazar"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.maturitas.2006.11.013"
                      "Revista" => array:6 [
                        "tituloSerie" => "Maturitas"
                        "fecha" => "2007"
                        "volumen" => "57"
                        "paginaInicial" => "214"
                        "paginaFinal" => "216"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17289310"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            5 => array:3 [
              "identificador" => "bib0075"
              "etiqueta" => "6"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "A Leydig cell tumor of the ovary resulting in extreme hyperandrogenism&#44; erythrocytosis&#44; and recurrent pulmonar embolism"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "P&#46; Kozan"
                            1 => "S&#46; Chalasani"
                            2 => "D&#46;J&#46; Handelsman"
                            3 => "A&#46;H&#46; Pike"
                            4 => "B&#46;A&#46; Crawford"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1210/jc.2013-3108"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Clin Endocrinol Metab"
                        "fecha" => "2014"
                        "volumen" => "99"
                        "paginaInicial" => "12"
                        "paginaFinal" => "17"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/24152686"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            6 => array:3 [
              "identificador" => "bib0080"
              "etiqueta" => "7"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "A rare case of hyperandrogenism&#58; Bilateral Leydig cell tumor of the ovary"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "M&#46; Marcelino"
                            1 => "E&#46; Nobre"
                            2 => "J&#46; Concei&#231;&#227;o"
                            3 => "L&#46; Lopes"
                            4 => "H&#46; Vilar"
                            5 => "M&#46; Fran&#231;a Martins"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Acta Med Port"
                        "fecha" => "2010"
                        "volumen" => "23"
                        "paginaInicial" => "113"
                        "paginaFinal" => "118"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/20353714"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            7 => array:3 [
              "identificador" => "bib0085"
              "etiqueta" => "8"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Intraoperative testosterone assay for virilizing ovarian tumor topographic assessment&#58; Report of a Leydig cell tumor of the ovary in a premenopausal woman with an adrenal incidentaloma"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "C&#46; Regnier"
                            1 => "A&#46; Bennet"
                            2 => "D&#46; Malet"
                            3 => "T&#46; Guez"
                            4 => "M&#46; Plantavid"
                            5 => "P&#46; Rochaix"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "J Clin EndocrinolMetab"
                        "fecha" => "2002"
                        "volumen" => "87"
                        "paginaInicial" => "3074"
                        "paginaFinal" => "3077"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            8 => array:3 [
              "identificador" => "bib0090"
              "etiqueta" => "9"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Hiperandrogenismo avanzado en una mujer posmenop&#225;usica&#46; Caso cl&#237;nico"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "P&#46; Salman"
                            1 => "M&#46; Cuello"
                            2 => "M&#46; Kolbach"
                            3 => "R&#46; Gejman"
                            4 => "E&#46; Arteaga"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "/S0034-98872011000800013"
                      "Revista" => array:6 [
                        "tituloSerie" => "Rev Med Chile"
                        "fecha" => "2011"
                        "volumen" => "139"
                        "paginaInicial" => "1066"
                        "paginaFinal" => "1070"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/22215338"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
          ]
        ]
      ]
    ]
  ]
  "idiomaDefecto" => "en"
  "url" => "/15782190/0000010600000008/v1_201510011018/S1578219015002024/v1_201510011018/en/main.assets"
  "Apartado" => array:4 [
    "identificador" => "6157"
    "tipo" => "SECCION"
    "en" => array:2 [
      "titulo" => "Case and Research Letters"
      "idiomaDefecto" => true
    ]
    "idiomaDefecto" => "en"
  ]
  "PDF" => "https://static.elsevier.es/multimedia/15782190/0000010600000008/v1_201510011018/S1578219015002024/v1_201510011018/en/main.pdf?idApp=UINPBA000044&text.app=https://actasdermo.org/"
  "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1578219015002024?idApp=UINPBA000044"
]
Información del artículo
ISSN: 15782190
Idioma original: Inglés
Datos actualizados diariamente
año/Mes Html Pdf Total
2024 Noviembre 11 9 20
2024 Octubre 122 59 181
2024 Septiembre 126 49 175
2024 Agosto 152 64 216
2024 Julio 129 57 186
2024 Junio 152 32 184
2024 Mayo 144 53 197
2024 Abril 109 34 143
2024 Marzo 110 36 146
2024 Febrero 87 37 124
2024 Enero 67 35 102
2023 Diciembre 106 20 126
2023 Noviembre 82 35 117
2023 Octubre 59 15 74
2023 Septiembre 88 30 118
2023 Agosto 67 22 89
2023 Julio 83 30 113
2023 Junio 79 25 104
2023 Mayo 100 23 123
2023 Abril 69 18 87
2023 Marzo 80 20 100
2023 Febrero 84 22 106
2023 Enero 62 21 83
2022 Diciembre 76 46 122
2022 Noviembre 41 26 67
2022 Octubre 42 26 68
2022 Septiembre 40 33 73
2022 Agosto 30 33 63
2022 Julio 28 43 71
2022 Junio 34 25 59
2022 Mayo 37 29 66
2022 Abril 298 39 337
2022 Marzo 328 53 381
2022 Febrero 63 30 93
2022 Enero 65 48 113
2021 Diciembre 52 36 88
2021 Noviembre 55 60 115
2021 Octubre 59 59 118
2021 Septiembre 65 40 105
2021 Agosto 52 29 81
2021 Julio 34 34 68
2021 Junio 24 24 48
2021 Mayo 37 28 65
2021 Abril 46 41 87
2021 Marzo 65 25 90
2021 Febrero 53 23 76
2021 Enero 30 19 49
2020 Diciembre 31 19 50
2020 Noviembre 20 14 34
2020 Octubre 31 8 39
2020 Septiembre 44 13 57
2020 Agosto 20 24 44
2020 Julio 17 18 35
2020 Junio 36 44 80
2020 Mayo 27 19 46
2020 Abril 34 21 55
2020 Marzo 37 21 58
2020 Febrero 4 1 5
2020 Enero 6 2 8
2019 Diciembre 8 0 8
2019 Noviembre 4 0 4
2019 Octubre 0 5 5
2019 Septiembre 6 4 10
2019 Agosto 4 2 6
2019 Julio 4 9 13
2019 Junio 4 20 24
2019 Mayo 6 32 38
2019 Abril 5 22 27
2019 Marzo 4 26 30
2019 Febrero 3 29 32
2019 Enero 13 11 24
2018 Diciembre 8 7 15
2018 Noviembre 11 0 11
2018 Octubre 13 0 13
2018 Septiembre 4 1 5
2018 Agosto 0 5 5
2018 Julio 0 8 8
2018 Junio 0 1 1
2018 Mayo 0 10 10
2018 Abril 0 2 2
2018 Marzo 0 2 2
2018 Febrero 26 4 30
2018 Enero 27 7 34
2017 Diciembre 33 9 42
2017 Noviembre 20 3 23
2017 Octubre 28 7 35
2017 Septiembre 23 9 32
2017 Agosto 23 5 28
2017 Julio 15 8 23
2017 Junio 25 15 40
2017 Mayo 22 9 31
2017 Abril 16 8 24
2017 Marzo 5 26 31
2017 Febrero 19 7 26
2017 Enero 8 4 12
2016 Diciembre 22 14 36
2016 Noviembre 30 23 53
2016 Octubre 27 21 48
2016 Septiembre 0 1 1
2016 Julio 2 1 3
2016 Junio 3 0 3
2016 Enero 0 1 1
2015 Noviembre 0 1 1
Mostrar todo

Siga este enlace para acceder al texto completo del artículo

Idiomas
Actas Dermo-Sifiliográficas
es en

¿Es usted profesional sanitario apto para prescribir o dispensar medicamentos?

Are you a health professional able to prescribe or dispense drugs?