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    "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">Morphea is a form of localized scleroderma that differs from systemic forms of the disease by the presence of well-characterized morphological variants and the absence of any clinically detectable extracutaneous involvement&#46; Many clinical classifications are employed&#44; but there are few management guidelines for use in daily clinical practice&#46;<a class="elsevierStyleCrossRef" href="#bib0055"><span class="elsevierStyleSup">1</span></a> The most recently published guideline includes the following clinical variants&#58; circumscribed morphea&#44; generalized morphea&#44; and the linear variant&#44; which is more typical in childhood&#46;<a class="elsevierStyleCrossRef" href="#bib0060"><span class="elsevierStyleSup">2</span></a> The linear variant is subdivided into 3 subtypes&#58; the purely linear form&#44; coup de sabre morphea&#44; and progressive facial hemiatrophy &#40;or Parry-Romberg syndrome&#41;&#46;</p><p id="par0010" class="elsevierStylePara elsevierViewall">We present the case of a 7-year-old boy with no past medical or family history of interest&#46; He was seen for a 7-mm long&#44; depressed&#44; hypopigmented&#44; slightly indurated band located on the left upper lip &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>&#41;&#46; The lesion had appeared more than 18 months earlier and had not previously been treated&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><p id="par0015" class="elsevierStylePara elsevierViewall">The possibility of performing a diagnostic biopsy was discussed with the family&#44; but&#44; given the cosmetic repercussion&#44; it was decided to use skin ultrasound to confirm the clinical diagnostic suspicion&#46; The ultrasound device employed was the Mylab&#8482;25 &#40;Esaote&#41; with a compact linear 18<span class="elsevierStyleHsp" style=""></span>MHz probe&#46; The study was used to support the clinical diagnosis and in particular to ensure correct monitoring of the disease&#46; To perform an accurate study of dermal and epidermal thickness requires a thick layer of gel to obtain a high-quality image&#59; pressure must not be applied to the skin&#44; as this could distort the image&#46; The ultrasound image revealed thinning of the epidermal layer and of the dermosubdermal space&#44; with increased echogenicity of the dermis compared with the adjacent skin &#40;<a class="elsevierStyleCrossRef" href="#fig0010">Fig&#46; 2</a>&#41;&#46; Doppler mode did not reveal increased vascularization in the area of the lesion&#46; The neurological examination was rigorously normal&#44; and additional laboratory tests were not requested&#46; A diagnosis of inactive linear morphea was made on the basis of the clinical appearance and a compatible ultrasound image&#44; and it was decided to take a wait-and-see approach&#46;</p><elsevierMultimedia ident="fig0010"></elsevierMultimedia><p id="par0020" class="elsevierStylePara elsevierViewall">Localized linear scleroderma is characterized by the presence of sclerotic bands with a linear distribution and hypo- or hyperpigmentation&#59; the bands usually arise on the upper or lower limbs&#46; These linear lesions may follow the Blaschko lines&#44; signifying that genetic mosaicism may contribute to the pathophysiology of the disease&#46;<a class="elsevierStyleCrossRef" href="#bib0065"><span class="elsevierStyleSup">3</span></a> Large&#44; deep lesions may be associated with muscle and bone atrophy and functional limitation due to joint involvement&#46;</p><p id="par0025" class="elsevierStylePara elsevierViewall">Ultrasound is a useful method for the diagnosis and&#44; in particular&#44; for the follow-up of diseases that affect the dermis and subcutaneous cellular tissue&#46;<a class="elsevierStyleCrossRefs" href="#bib0070"><span class="elsevierStyleSup">4&#44;5</span></a> Although the ultrasound findings are sometimes nonspecific&#44; as occurred in our case&#44; they can be very useful when combined with the patient&#39;s clinical manifestations to clarify the differential diagnosis&#46; Most research into linear scleroderma reported in the literature describes the use of 20<span class="elsevierStyleHsp" style=""></span>MHz probes&#44; as they reach a maximum depth of 10<span class="elsevierStyleHsp" style=""></span>mm&#44; which should be sufficient to determine the thickness and echogenicity of the lesion&#46;<a class="elsevierStyleCrossRef" href="#bib0080"><span class="elsevierStyleSup">6</span></a></p><p id="par0030" class="elsevierStylePara elsevierViewall">Evaluation of the clinical activity of localized scleroderma can be complicated&#44; as it is based on observation of the clinical manifestations&#58; presence or absence of erythema&#44; lesion spread&#44; or appearance of new lesions&#46;</p><p id="par0035" class="elsevierStylePara elsevierViewall">However&#44; the progression of morphea can initially affect deeper layers and be clinically undetectable&#46; This can delay the early initiation of treatment&#46;<a class="elsevierStyleCrossRef" href="#bib0085"><span class="elsevierStyleSup">7</span></a></p><p id="par0040" class="elsevierStylePara elsevierViewall">The difference in thickness between affected skin and normal skin does not correlate with disease activity&#46; The different characteristics that should be taken into consideration are overall echogenicity of the lesion&#44; hypoechogenicity of the hypodermis&#44; and increased vascularization of the deep dermis&#46; These parameters&#44; which do appear to correlate with increased clinical activity&#44;<a class="elsevierStyleCrossRef" href="#bib0090"><span class="elsevierStyleSup">8</span></a> were evaluated in our patient and enabled us to take a wait-and-see approach&#46; When morphea is in a clinically stable phase&#44; skin ultrasound reveals only a minimal difference in overall echogenicity between affected skin and normal skin&#44; as was found in our patient&#46;<a class="elsevierStyleCrossRefs" href="#bib0095"><span class="elsevierStyleSup">9&#44;10</span></a></p><p id="par0045" class="elsevierStylePara elsevierViewall">In conclusion&#44; skin ultrasound is a non-invasive technique that can reduce the need for skin biopsy&#44; particularly when the clinical findings are highly suggestive&#44; as in our patient&#44; or when histology has already been performed&#44; avoiding cosmetic repercussions in visible areas&#46; The dermatologist must learn to perform ultrasound studies&#44; as they enable plaques of morphea to be monitored and contribute not only to the ability to take a wait-and-see approach but also to monitoring the efficacy of treatments&#46;</p></span>"
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Case and Research Letter
Ultrasound Monitoring of Childhood Linear Morphea
Monitorización ecográfica de la morfea lineal de la infancia
I. Pérez-López
Autor para correspondencia
ipl_elmadrono@hotmail.com

Corresponding author.
, C. Garrido-Colmenero, R. Ruiz-Villaverde, J. Tercedor-Sánchez
Unidad de Gestión Clínica de Dermatología Médico Quirúrgica y Venereología, Hospital Universitario Virgen de las Nieves, Granada, Spain
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    "titulo" => "Ultrasound Monitoring of Childhood Linear Morphea"
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          "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Depressed linear lesion on the left upper lip in our patient&#46;</p>"
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    "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">Morphea is a form of localized scleroderma that differs from systemic forms of the disease by the presence of well-characterized morphological variants and the absence of any clinically detectable extracutaneous involvement&#46; Many clinical classifications are employed&#44; but there are few management guidelines for use in daily clinical practice&#46;<a class="elsevierStyleCrossRef" href="#bib0055"><span class="elsevierStyleSup">1</span></a> The most recently published guideline includes the following clinical variants&#58; circumscribed morphea&#44; generalized morphea&#44; and the linear variant&#44; which is more typical in childhood&#46;<a class="elsevierStyleCrossRef" href="#bib0060"><span class="elsevierStyleSup">2</span></a> The linear variant is subdivided into 3 subtypes&#58; the purely linear form&#44; coup de sabre morphea&#44; and progressive facial hemiatrophy &#40;or Parry-Romberg syndrome&#41;&#46;</p><p id="par0010" class="elsevierStylePara elsevierViewall">We present the case of a 7-year-old boy with no past medical or family history of interest&#46; He was seen for a 7-mm long&#44; depressed&#44; hypopigmented&#44; slightly indurated band located on the left upper lip &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>&#41;&#46; The lesion had appeared more than 18 months earlier and had not previously been treated&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><p id="par0015" class="elsevierStylePara elsevierViewall">The possibility of performing a diagnostic biopsy was discussed with the family&#44; but&#44; given the cosmetic repercussion&#44; it was decided to use skin ultrasound to confirm the clinical diagnostic suspicion&#46; The ultrasound device employed was the Mylab&#8482;25 &#40;Esaote&#41; with a compact linear 18<span class="elsevierStyleHsp" style=""></span>MHz probe&#46; The study was used to support the clinical diagnosis and in particular to ensure correct monitoring of the disease&#46; To perform an accurate study of dermal and epidermal thickness requires a thick layer of gel to obtain a high-quality image&#59; pressure must not be applied to the skin&#44; as this could distort the image&#46; The ultrasound image revealed thinning of the epidermal layer and of the dermosubdermal space&#44; with increased echogenicity of the dermis compared with the adjacent skin &#40;<a class="elsevierStyleCrossRef" href="#fig0010">Fig&#46; 2</a>&#41;&#46; Doppler mode did not reveal increased vascularization in the area of the lesion&#46; The neurological examination was rigorously normal&#44; and additional laboratory tests were not requested&#46; A diagnosis of inactive linear morphea was made on the basis of the clinical appearance and a compatible ultrasound image&#44; and it was decided to take a wait-and-see approach&#46;</p><elsevierMultimedia ident="fig0010"></elsevierMultimedia><p id="par0020" class="elsevierStylePara elsevierViewall">Localized linear scleroderma is characterized by the presence of sclerotic bands with a linear distribution and hypo- or hyperpigmentation&#59; the bands usually arise on the upper or lower limbs&#46; These linear lesions may follow the Blaschko lines&#44; signifying that genetic mosaicism may contribute to the pathophysiology of the disease&#46;<a class="elsevierStyleCrossRef" href="#bib0065"><span class="elsevierStyleSup">3</span></a> Large&#44; deep lesions may be associated with muscle and bone atrophy and functional limitation due to joint involvement&#46;</p><p id="par0025" class="elsevierStylePara elsevierViewall">Ultrasound is a useful method for the diagnosis and&#44; in particular&#44; for the follow-up of diseases that affect the dermis and subcutaneous cellular tissue&#46;<a class="elsevierStyleCrossRefs" href="#bib0070"><span class="elsevierStyleSup">4&#44;5</span></a> Although the ultrasound findings are sometimes nonspecific&#44; as occurred in our case&#44; they can be very useful when combined with the patient&#39;s clinical manifestations to clarify the differential diagnosis&#46; Most research into linear scleroderma reported in the literature describes the use of 20<span class="elsevierStyleHsp" style=""></span>MHz probes&#44; as they reach a maximum depth of 10<span class="elsevierStyleHsp" style=""></span>mm&#44; which should be sufficient to determine the thickness and echogenicity of the lesion&#46;<a class="elsevierStyleCrossRef" href="#bib0080"><span class="elsevierStyleSup">6</span></a></p><p id="par0030" class="elsevierStylePara elsevierViewall">Evaluation of the clinical activity of localized scleroderma can be complicated&#44; as it is based on observation of the clinical manifestations&#58; presence or absence of erythema&#44; lesion spread&#44; or appearance of new lesions&#46;</p><p id="par0035" class="elsevierStylePara elsevierViewall">However&#44; the progression of morphea can initially affect deeper layers and be clinically undetectable&#46; This can delay the early initiation of treatment&#46;<a class="elsevierStyleCrossRef" href="#bib0085"><span class="elsevierStyleSup">7</span></a></p><p id="par0040" class="elsevierStylePara elsevierViewall">The difference in thickness between affected skin and normal skin does not correlate with disease activity&#46; The different characteristics that should be taken into consideration are overall echogenicity of the lesion&#44; hypoechogenicity of the hypodermis&#44; and increased vascularization of the deep dermis&#46; These parameters&#44; which do appear to correlate with increased clinical activity&#44;<a class="elsevierStyleCrossRef" href="#bib0090"><span class="elsevierStyleSup">8</span></a> were evaluated in our patient and enabled us to take a wait-and-see approach&#46; When morphea is in a clinically stable phase&#44; skin ultrasound reveals only a minimal difference in overall echogenicity between affected skin and normal skin&#44; as was found in our patient&#46;<a class="elsevierStyleCrossRefs" href="#bib0095"><span class="elsevierStyleSup">9&#44;10</span></a></p><p id="par0045" class="elsevierStylePara elsevierViewall">In conclusion&#44; skin ultrasound is a non-invasive technique that can reduce the need for skin biopsy&#44; particularly when the clinical findings are highly suggestive&#44; as in our patient&#44; or when histology has already been performed&#44; avoiding cosmetic repercussions in visible areas&#46; The dermatologist must learn to perform ultrasound studies&#44; as they enable plaques of morphea to be monitored and contribute not only to the ability to take a wait-and-see approach but also to monitoring the efficacy of treatments&#46;</p></span>"
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        "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Please cite this article as&#58; P&#233;rez-L&#243;pez I&#44; Garrido-Colmenero C&#44; Ruiz-Villaverde R&#44; Tercedor-S&#225;nchez J&#46; Monitorizaci&#243;n ecogr&#225;fica de la morfea lineal de la infancia&#46; Actas Dermosifiliogr&#46; 2015&#59;106&#58;340&#8211;342&#46;</p>"
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                            5 => "T&#46; Kornyat"
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Información del artículo
ISSN: 15782190
Idioma original: Inglés
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