array:23 [
  "pii" => "S157821901500061X"
  "issn" => "15782190"
  "doi" => "10.1016/j.adengl.2015.03.011"
  "estado" => "S300"
  "fechaPublicacion" => "2015-05-01"
  "aid" => "1065"
  "copyright" => "Elsevier España, S.L.U. and AEDV"
  "copyrightAnyo" => "2014"
  "documento" => "simple-article"
  "subdocumento" => "cor"
  "cita" => "Actas Dermosifiliogr. 2015;106:327-9"
  "abierto" => array:3 [
    "ES" => true
    "ES2" => true
    "LATM" => true
  ]
  "gratuito" => true
  "lecturas" => array:2 [
    "total" => 1153
    "formatos" => array:3 [
      "EPUB" => 51
      "HTML" => 829
      "PDF" => 273
    ]
  ]
  "Traduccion" => array:1 [
    "es" => array:18 [
      "pii" => "S0001731014004499"
      "issn" => "00017310"
      "doi" => "10.1016/j.ad.2014.08.009"
      "estado" => "S300"
      "fechaPublicacion" => "2015-05-01"
      "aid" => "1065"
      "copyright" => "Elsevier España, S.L.U. y AEDV"
      "documento" => "simple-article"
      "subdocumento" => "cor"
      "cita" => "Actas Dermosifiliogr. 2015;106:327-9"
      "abierto" => array:3 [
        "ES" => true
        "ES2" => true
        "LATM" => true
      ]
      "gratuito" => true
      "lecturas" => array:2 [
        "total" => 1485
        "formatos" => array:3 [
          "EPUB" => 3
          "HTML" => 886
          "PDF" => 596
        ]
      ]
      "es" => array:11 [
        "idiomaDefecto" => true
        "cabecera" => "<span class="elsevierStyleTextfn">Carta cient&#237;fico-cl&#237;nica</span>"
        "titulo" => "Frinoderma asociado a derivaci&#243;n biliopancre&#225;tica"
        "tienePdf" => "es"
        "tieneTextoCompleto" => "es"
        "paginas" => array:1 [
          0 => array:2 [
            "paginaInicial" => "327"
            "paginaFinal" => "329"
          ]
        ]
        "titulosAlternativos" => array:1 [
          "en" => array:1 [
            "titulo" => "Phrynoderma After Biliopancreatic Diversion"
          ]
        ]
        "contieneTextoCompleto" => array:1 [
          "es" => true
        ]
        "contienePdf" => array:1 [
          "es" => true
        ]
        "resumenGrafico" => array:2 [
          "original" => 0
          "multimedia" => array:7 [
            "identificador" => "fig0010"
            "etiqueta" => "Figura 2"
            "tipo" => "MULTIMEDIAFIGURA"
            "mostrarFloat" => true
            "mostrarDisplay" => false
            "figura" => array:1 [
              0 => array:4 [
                "imagen" => "gr2.jpeg"
                "Alto" => 741
                "Ancho" => 990
                "Tamanyo" => 253122
              ]
            ]
            "descripcion" => array:1 [
              "es" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Dilataci&#243;n de los infund&#237;bulos foliculares con tapones querat&#243;sicos centrales &#40;H-E&#44; 20x&#41;&#46;</p>"
            ]
          ]
        ]
        "autores" => array:1 [
          0 => array:2 [
            "autoresLista" => "L&#46; Abad, T&#46; Omiste, J&#46; Vera, Y&#46; Gilaberte"
            "autores" => array:4 [
              0 => array:2 [
                "nombre" => "L&#46;"
                "apellidos" => "Abad"
              ]
              1 => array:2 [
                "nombre" => "T&#46;"
                "apellidos" => "Omiste"
              ]
              2 => array:2 [
                "nombre" => "J&#46;"
                "apellidos" => "Vera"
              ]
              3 => array:2 [
                "nombre" => "Y&#46;"
                "apellidos" => "Gilaberte"
              ]
            ]
          ]
        ]
      ]
      "idiomaDefecto" => "es"
      "Traduccion" => array:1 [
        "en" => array:9 [
          "pii" => "S157821901500061X"
          "doi" => "10.1016/j.adengl.2015.03.011"
          "estado" => "S300"
          "subdocumento" => ""
          "abierto" => array:3 [
            "ES" => true
            "ES2" => true
            "LATM" => true
          ]
          "gratuito" => true
          "lecturas" => array:1 [
            "total" => 0
          ]
          "idiomaDefecto" => "en"
          "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S157821901500061X?idApp=UINPBA000044"
        ]
      ]
      "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0001731014004499?idApp=UINPBA000044"
      "url" => "/00017310/0000010600000004/v2_201505051016/S0001731014004499/v2_201505051016/es/main.assets"
    ]
  ]
  "itemSiguiente" => array:18 [
    "pii" => "S1578219015000621"
    "issn" => "15782190"
    "doi" => "10.1016/j.adengl.2015.03.012"
    "estado" => "S300"
    "fechaPublicacion" => "2015-05-01"
    "aid" => "1066"
    "copyright" => "Elsevier Espa&#241;a&#44; S&#46;L&#46;U&#46; and AEDV"
    "documento" => "simple-article"
    "subdocumento" => "cor"
    "cita" => "Actas Dermosifiliogr. 2015;106:329-31"
    "abierto" => array:3 [
      "ES" => true
      "ES2" => true
      "LATM" => true
    ]
    "gratuito" => true
    "lecturas" => array:2 [
      "total" => 1532
      "formatos" => array:3 [
        "EPUB" => 53
        "HTML" => 1252
        "PDF" => 227
      ]
    ]
    "en" => array:11 [
      "idiomaDefecto" => true
      "cabecera" => "<span class="elsevierStyleTextfn">Case and Research Letter</span>"
      "titulo" => "Herpes Zoster in Children Vaccinated Against Varicella-Zoster Virus&#58; Experience in our Hospital"
      "tienePdf" => "en"
      "tieneTextoCompleto" => "en"
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "329"
          "paginaFinal" => "331"
        ]
      ]
      "titulosAlternativos" => array:1 [
        "es" => array:1 [
          "titulo" => "Herpes z&#243;ster en ni&#241;os vacunados contra el virus varicela z&#243;ster&#58; experiencia en nuestro hospital"
        ]
      ]
      "contieneTextoCompleto" => array:1 [
        "en" => true
      ]
      "contienePdf" => array:1 [
        "en" => true
      ]
      "resumenGrafico" => array:2 [
        "original" => 0
        "multimedia" => array:7 [
          "identificador" => "fig0005"
          "etiqueta" => "Figure 1"
          "tipo" => "MULTIMEDIAFIGURA"
          "mostrarFloat" => true
          "mostrarDisplay" => false
          "figura" => array:1 [
            0 => array:4 [
              "imagen" => "gr1.jpeg"
              "Alto" => 884
              "Ancho" => 1600
              "Tamanyo" => 182550
            ]
          ]
          "descripcion" => array:1 [
            "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Clinical characteristics of the herpes zoster lesions in 4 of the patients in our series&#46;</p>"
          ]
        ]
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "D&#46; Caro-Guti&#233;rrez, J&#46;L&#46; L&#243;pez-Estebaranz, E&#46; Naz-Villalba, L&#46; Ayala-Bernaldo de Quiros"
          "autores" => array:4 [
            0 => array:2 [
              "nombre" => "D&#46;"
              "apellidos" => "Caro-Guti&#233;rrez"
            ]
            1 => array:2 [
              "nombre" => "J&#46;L&#46;"
              "apellidos" => "L&#243;pez-Estebaranz"
            ]
            2 => array:2 [
              "nombre" => "E&#46;"
              "apellidos" => "Naz-Villalba"
            ]
            3 => array:2 [
              "nombre" => "L&#46;"
              "apellidos" => "Ayala-Bernaldo de Quiros"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "en"
    "Traduccion" => array:1 [
      "es" => array:9 [
        "pii" => "S0001731014004505"
        "doi" => "10.1016/j.ad.2014.07.007"
        "estado" => "S300"
        "subdocumento" => ""
        "abierto" => array:3 [
          "ES" => true
          "ES2" => true
          "LATM" => true
        ]
        "gratuito" => true
        "lecturas" => array:1 [
          "total" => 0
        ]
        "idiomaDefecto" => "es"
        "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0001731014004505?idApp=UINPBA000044"
      ]
    ]
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1578219015000621?idApp=UINPBA000044"
    "url" => "/15782190/0000010600000004/v2_201505051007/S1578219015000621/v2_201505051007/en/main.assets"
  ]
  "itemAnterior" => array:18 [
    "pii" => "S1578219015000608"
    "issn" => "15782190"
    "doi" => "10.1016/j.adengl.2015.03.010"
    "estado" => "S300"
    "fechaPublicacion" => "2015-05-01"
    "aid" => "1060"
    "copyright" => "Elsevier Espa&#241;a&#44; S&#46;L&#46;U&#46; and AEDV"
    "documento" => "simple-article"
    "subdocumento" => "cor"
    "cita" => "Actas Dermosifiliogr. 2015;106:326-7"
    "abierto" => array:3 [
      "ES" => true
      "ES2" => true
      "LATM" => true
    ]
    "gratuito" => true
    "lecturas" => array:2 [
      "total" => 1080
      "formatos" => array:3 [
        "EPUB" => 47
        "HTML" => 603
        "PDF" => 430
      ]
    ]
    "en" => array:10 [
      "idiomaDefecto" => true
      "cabecera" => "<span class="elsevierStyleTextfn">Case and Research letter</span>"
      "titulo" => "Gastric Mucosa-Associated Lymphoid Tissue Lymphoma in a Patient With Severe Psoriasis Receiving Ustekinumab"
      "tienePdf" => "en"
      "tieneTextoCompleto" => "en"
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "326"
          "paginaFinal" => "327"
        ]
      ]
      "titulosAlternativos" => array:1 [
        "es" => array:1 [
          "titulo" => "Linfoma g&#225;strico de tejido linfoide asociado a mucosa en un paciente con psoriasis grave en tratamiento con ustekinumab"
        ]
      ]
      "contieneTextoCompleto" => array:1 [
        "en" => true
      ]
      "contienePdf" => array:1 [
        "en" => true
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "J&#46; Gonz&#225;lez-Ramos, M&#46;L&#46; Alonso-Pacheco, A&#46; Mayor-Ibarguren, P&#46; Herranz-Pinto"
          "autores" => array:4 [
            0 => array:2 [
              "nombre" => "J&#46;"
              "apellidos" => "Gonz&#225;lez-Ramos"
            ]
            1 => array:2 [
              "nombre" => "M&#46;L&#46;"
              "apellidos" => "Alonso-Pacheco"
            ]
            2 => array:2 [
              "nombre" => "A&#46;"
              "apellidos" => "Mayor-Ibarguren"
            ]
            3 => array:2 [
              "nombre" => "P&#46;"
              "apellidos" => "Herranz-Pinto"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "en"
    "Traduccion" => array:1 [
      "es" => array:9 [
        "pii" => "S0001731014004190"
        "doi" => "10.1016/j.ad.2014.05.010"
        "estado" => "S300"
        "subdocumento" => ""
        "abierto" => array:3 [
          "ES" => true
          "ES2" => true
          "LATM" => true
        ]
        "gratuito" => true
        "lecturas" => array:1 [
          "total" => 0
        ]
        "idiomaDefecto" => "es"
        "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0001731014004190?idApp=UINPBA000044"
      ]
    ]
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1578219015000608?idApp=UINPBA000044"
    "url" => "/15782190/0000010600000004/v2_201505051007/S1578219015000608/v2_201505051007/en/main.assets"
  ]
  "en" => array:14 [
    "idiomaDefecto" => true
    "cabecera" => "<span class="elsevierStyleTextfn">Case and Research Letter</span>"
    "titulo" => "Phrynoderma After Biliopancreatic Diversion"
    "tieneTextoCompleto" => true
    "paginas" => array:1 [
      0 => array:2 [
        "paginaInicial" => "327"
        "paginaFinal" => "329"
      ]
    ]
    "autores" => array:1 [
      0 => array:4 [
        "autoresLista" => "L&#46; Abad, T&#46; Omiste, J&#46; Vera, Y&#46; Gilaberte"
        "autores" => array:4 [
          0 => array:4 [
            "nombre" => "L&#46;"
            "apellidos" => "Abad"
            "email" => array:1 [
              0 => "laura&#46;abad&#46;polo&#64;gmail&#46;com"
            ]
            "referencia" => array:2 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">a</span>"
                "identificador" => "aff0005"
              ]
              1 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">&#42;</span>"
                "identificador" => "cor0005"
              ]
            ]
          ]
          1 => array:3 [
            "nombre" => "T&#46;"
            "apellidos" => "Omiste"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">b</span>"
                "identificador" => "aff0010"
              ]
            ]
          ]
          2 => array:3 [
            "nombre" => "J&#46;"
            "apellidos" => "Vera"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">c</span>"
                "identificador" => "aff0015"
              ]
            ]
          ]
          3 => array:3 [
            "nombre" => "Y&#46;"
            "apellidos" => "Gilaberte"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">d</span>"
                "identificador" => "aff0020"
              ]
            ]
          ]
        ]
        "afiliaciones" => array:4 [
          0 => array:3 [
            "entidad" => "Medicina de Familia y Comunitaria&#44; Hospital San Jorge&#44; Huesca&#44; Spain"
            "etiqueta" => "a"
            "identificador" => "aff0005"
          ]
          1 => array:3 [
            "entidad" => "Servicio de Medicina Interna&#44; Hospital San Jorge&#44; Huesca&#44; Spain"
            "etiqueta" => "b"
            "identificador" => "aff0010"
          ]
          2 => array:3 [
            "entidad" => "Servicio de Anatom&#237;a Patol&#243;gica&#44; Hospital San Jorge&#44; Huesca&#44; Spain"
            "etiqueta" => "c"
            "identificador" => "aff0015"
          ]
          3 => array:3 [
            "entidad" => "Servicio de Dermatolog&#237;a&#44; Hospital San Jorge&#44; Huesca&#44; Spain"
            "etiqueta" => "d"
            "identificador" => "aff0020"
          ]
        ]
        "correspondencia" => array:1 [
          0 => array:3 [
            "identificador" => "cor0005"
            "etiqueta" => "&#8270;"
            "correspondencia" => "Corresponding author&#46;"
          ]
        ]
      ]
    ]
    "titulosAlternativos" => array:1 [
      "es" => array:1 [
        "titulo" => "Frinoderma asociado a derivaci&#243;n biliopancre&#225;tica"
      ]
    ]
    "resumenGrafico" => array:2 [
      "original" => 0
      "multimedia" => array:7 [
        "identificador" => "fig0005"
        "etiqueta" => "Figure 1"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr1.jpeg"
            "Alto" => 598
            "Ancho" => 1600
            "Tamanyo" => 180795
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">A&#44; Violaceous&#44; suppurating papular and tuberose lesions&#44; some with scabs&#46; B&#44; Resolution of the phrynoderma lesions&#46;</p>"
        ]
      ]
    ]
    "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">Current surgical techniques for the treatment of morbid obesity can lead to major systemic complications&#46; Biliopancreatic bypass surgery is a mixed restrictive-malabsorptive type of bariatric surgery that combines partial gastrectomy with a gastroileal anastomosis&#44; causing the bile and pancreatic secretions to mix with the foods only in the final 50<span class="elsevierStyleHsp" style=""></span>cm of the small bowel&#46; In the long term&#44; this considerably reduces the absorption of vitamins&#44; oligoelements&#44; and essential fatty acids&#46;</p><p id="par0010" class="elsevierStylePara elsevierViewall">Our patient was a man of 46 years of age&#44; with a history of obesity&#44; hypertension&#44; tuberculous lymphadenitis in 2005&#44; a biliopancreatic bypass operation in 1999&#44; and operations for an anal fistula and to perform dermolipectomy in the hypogastrium and flanks&#46; He was on treatment with valsartan&#44; venotonic agents&#44; ferrous sulfate&#44; and Dayamineral &#40;a vitamin and mineral supplement&#41;&#46; He was seen in dermatology in 2012 for suppurating lesions on the lower limbs&#46; The lesions had appeared when he started to lose weight after the bariatric surgery and they had gradually spread to the trunk and upper limbs&#46; The diagnoses from 2 skin biopsies performed in 2003 were folliculitis and furuncle&#44; respectively&#46; Cultures for bacteria&#44; fungi&#44; and mycobacteria were repeatedly negative and various oral antibiotic treatments did not resolve the condition&#46; On physical examination there were violaceous papular and tuberose lesions&#44; some with scabs&#44; situated mainly on the thighs and on the medial aspect of the knees&#44; but with isolated lesions on the abdomen and on the proximal areas of the upper limbs &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>A&#41;&#46; Histopathology revealed the presence of intense hyperkeratosis in the pilosebaceous follicles&#44; giving rise to the formation of keratin cysts&#46; There was also a small abscess with residues of fragmented collagen and the presence of macrophages and neutrophils &#40;<a class="elsevierStyleCrossRef" href="#fig0010">Fig&#46; 2</a>&#41;&#46; No fragmentation of elastic fibers was detected&#46; Special techniques did not reveal the presence of fungi or of mycobacteria&#46; A provisional diagnosis of phrynoderma was made based on these findings&#46; Blood tests confirmed the deficit of vitamin A &#40;0&#46;15<span class="elsevierStyleHsp" style=""></span>mg&#47;L &#91;normal range&#44; 0&#46;30-1<span class="elsevierStyleHsp" style=""></span>mg&#47;L&#93;&#41;&#44; as well as of vitamin E &#40;4&#46;9<span class="elsevierStyleHsp" style=""></span>&#956;g&#47;mL &#91;normal range&#44; 5-20<span class="elsevierStyleHsp" style=""></span>&#956;g&#47;mL&#93;&#41;&#44; Vitamin D<span class="elsevierStyleInf">3</span> &#40;14&#46;18<span class="elsevierStyleHsp" style=""></span>ng&#47;mL &#91;normal range&#44; 20-32<span class="elsevierStyleHsp" style=""></span>ng&#47;mL&#93;&#41;&#44; and zinc &#40;43<span class="elsevierStyleHsp" style=""></span>&#956;g&#47;dL&#41;&#44; as well as a low hemoglobin level &#40;11&#46;4<span class="elsevierStyleHsp" style=""></span>g&#47;dL&#41; and low hematocrit 34&#37;&#46; Oral treatment was therefore prescribed as follows&#58; vitamin A &#40;1000<span class="elsevierStyleHsp" style=""></span>IU&#47;d&#41;&#59; vitamin E &#40;20<span class="elsevierStyleHsp" style=""></span>mg&#47;d&#41;&#59; calcifediol &#40;1 ampoule of 3<span class="elsevierStyleHsp" style=""></span>mg&#47;1&#46;5<span class="elsevierStyleHsp" style=""></span>mL per week&#41;&#59; Hidroxil-B<span class="elsevierStyleInf">12</span>-B<span class="elsevierStyleInf">6</span>-B<span class="elsevierStyleInf">1</span>&#59; Dayamineral&#44; 1 tablet once a day&#59; ferrous iron &#40;80<span class="elsevierStyleHsp" style=""></span>mg&#47;d&#41;&#59; and oil rich in medium-chain triglycerides&#46; After 7 months of treatment the skin lesions had not improved and the serum levels of vitamin A &#40;0&#46;11<span class="elsevierStyleHsp" style=""></span>mg&#47;L&#41; and vitamin E &#40;5&#46;1<span class="elsevierStyleHsp" style=""></span>&#956;g&#47;mL&#41;&#44; Zn &#40;52<span class="elsevierStyleHsp" style=""></span>&#956;g&#47;dL&#41;&#44; the hemoglobin level &#40;11&#46;0<span class="elsevierStyleHsp" style=""></span>g&#47;dL&#41;&#44; and the hematocrit 33&#37; were still low&#46; Intravenous iron &#40;500<span class="elsevierStyleHsp" style=""></span>mg of iron&#41;&#44; intramuscular vitamin A &#40;100&#160;000<span class="elsevierStyleHsp" style=""></span>IU&#47;mo&#41; and zinc sulfate &#40;22&#46;5<span class="elsevierStyleHsp" style=""></span>mg&#47;d&#41; were therefore added to the patient&#39;s treatment&#46; Three months later the vitamin levels were normal &#40;vitamin A&#44; 0&#46;38<span class="elsevierStyleHsp" style=""></span>mg&#47;L&#41;&#44; the anemia had resolved&#44; and only residual areas of hyperpigmentation were present on the skin &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>B&#41;&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><elsevierMultimedia ident="fig0010"></elsevierMultimedia><p id="par0015" class="elsevierStylePara elsevierViewall">Phrynoderma is the characteristic dermatosis associated with a deficiency of vitamin A&#44; a fat-soluble vitamin involved in numerous body functions&#46; Although this vitamin deficiency is common in Africa and southeast Asia&#44; phrynoderma is rare in Spain&#44; where it is associated with malabsorptive states&#44; such as pancreatic insufficiency&#44; colectomy&#44; and chronic giardiasis&#44; or arises as a complication of bariatric surgery&#46;<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">1</span></a></p><p id="par0020" class="elsevierStylePara elsevierViewall">Vitamin A deficiency is very common among patients who have undergone bariatric surgery and it has been associated with low prealbumin levels&#44; leading to a suggestion to use vitamin A levels as a marker of protein-energy malnutrition in these patients&#46;<a class="elsevierStyleCrossRef" href="#bib0040"><span class="elsevierStyleSup">2</span></a></p><p id="par0025" class="elsevierStylePara elsevierViewall">Phrynoderma is characterized by the presence of follicular hyperkeratosis&#44; mainly affecting the extensor surfaces of the limbs&#44; the abdomen&#44; and back&#46; It is often associated with xerosis and hyperpigmentation&#44; as well as extracutaneous manifestations such as night blindness&#46; The majority of reports of phrynoderma secondary to biliopancreatic bypass surgery describe atypical lesions that are larger and more inflammatory and tend to arise in atypical sites&#44; as occurred in our patient&#46;<a class="elsevierStyleCrossRef" href="#bib0045"><span class="elsevierStyleSup">3</span></a> Deficits of many other essential oligoelements and vitamins observed in these patients may contribute to this atypical presentation&#44; particularly if we consider that phrynoderma does not appear to have a single etiology&#46;<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">1</span></a> For example&#44; furunculosis has been described in association with iron deficiency and has improved after restoring normal iron levels<a class="elsevierStyleCrossRef" href="#bib0050"><span class="elsevierStyleSup">4</span></a>&#59; this diagnosis had to be considered in our patient as the first biopsies were compatible with this skin disorder&#46;</p><p id="par0030" class="elsevierStylePara elsevierViewall">From a clinical point of view&#44; the differential diagnosis must include other skin conditions that have been described in association with bariatric surgery&#44; such as dermatosis-arthritis syndrome&#44; neutrophilic dermatosis attributed to the formation of circulating immune complexes produced in the blind loop of bowel&#44;<a class="elsevierStyleCrossRef" href="#bib0055"><span class="elsevierStyleSup">5</span></a> and acrodermatitis related to zinc deficiency&#46;<a class="elsevierStyleCrossRef" href="#bib0060"><span class="elsevierStyleSup">6</span></a> We also considered the perforating dermatoses&#44; although no association with bariatric surgery has been reported&#46;</p><p id="par0035" class="elsevierStylePara elsevierViewall">The increase in obesity in western society means that bariatric surgery will become more common&#46; The conclusion from the present case is that patients undergoing bariatric surgery must be followed up closely by a multidisciplinary team that is aware of the nutritional risks and complications&#44; as well as the appropriate therapeutic strategies that patients must follow for life&#46;</p></span>"
    "pdfFichero" => "main.pdf"
    "tienePdf" => true
    "NotaPie" => array:1 [
      0 => array:2 [
        "etiqueta" => "&#9734;"
        "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Please cite this article as&#58; Abad L&#44; Omiste T&#44; Vera J&#44; Gilaberte Y&#46; Frinoderma asociado a derivaci&#243;n biliopancre&#225;tica&#46; Actas Dermosifiliogr&#46; 2015&#59;106&#58;327&#8211;329&#46;</p>"
      ]
    ]
    "multimedia" => array:2 [
      0 => array:7 [
        "identificador" => "fig0005"
        "etiqueta" => "Figure 1"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr1.jpeg"
            "Alto" => 598
            "Ancho" => 1600
            "Tamanyo" => 180795
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">A&#44; Violaceous&#44; suppurating papular and tuberose lesions&#44; some with scabs&#46; B&#44; Resolution of the phrynoderma lesions&#46;</p>"
        ]
      ]
      1 => array:7 [
        "identificador" => "fig0010"
        "etiqueta" => "Figure 2"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr2.jpeg"
            "Alto" => 741
            "Ancho" => 990
            "Tamanyo" => 257745
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Dilation of the follicular infundibulum with central keratotic plugs &#40;hematoxylin and eosin&#44; original magnification x<span class="elsevierStyleHsp" style=""></span>20&#41;&#46;</p>"
        ]
      ]
    ]
    "bibliografia" => array:2 [
      "titulo" => "References"
      "seccion" => array:1 [
        0 => array:2 [
          "identificador" => "bibs0005"
          "bibliografiaReferencia" => array:6 [
            0 => array:3 [
              "identificador" => "bib0035"
              "etiqueta" => "1"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Biliopancreatic diversion&#58; When a cure becomes a disease"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "C&#46; Panetta"
                            1 => "G&#46; Polino"
                            2 => "L&#46; Muscardin"
                            3 => "M&#46; Donati"
                            4 => "P&#46; Danati"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1097/DAD.0b013e3182926665"
                      "Revista" => array:6 [
                        "tituloSerie" => "Am J Dermatopathol"
                        "fecha" => "2014"
                        "volumen" => "36"
                        "paginaInicial" => "258"
                        "paginaFinal" => "259"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/23719482"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            1 => array:3 [
              "identificador" => "bib0040"
              "etiqueta" => "2"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Vitamin A deficiency after gastric bypass surgery&#58; An underreported postoperative complication"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "K&#46;C&#46; Zalesin"
                            1 => "W&#46;M&#46; Miller"
                            2 => "B&#46; Franklin"
                            3 => "D&#46; Mudugal"
                            4 => "A&#46; Rao Buragadda"
                            5 => "K&#46; Nori-Janosz"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:3 [
                        "tituloSerie" => "J Obes"
                        "fecha" => "2011"
                        "paginaInicial" => "2011"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            2 => array:3 [
              "identificador" => "bib0045"
              "etiqueta" => "3"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Frinoderma secundario a d&#233;ficit de vitamina A en un paciente con derivaci&#243;n biliopancre&#225;tica"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "J&#46; Oc&#243;n Bret&#243;n"
                            1 => "M&#46; Cabrejas G&#243;mez"
                            2 => "J&#46; Altemir Trallero"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1590/S0212-16112011000200027"
                      "Revista" => array:6 [
                        "tituloSerie" => "Nutr Hosp"
                        "fecha" => "2011"
                        "volumen" => "26"
                        "paginaInicial" => "421"
                        "paginaFinal" => "424"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/21666984"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            3 => array:3 [
              "identificador" => "bib0050"
              "etiqueta" => "4"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Preliminary report&#58; Furunculosis and hypoferraemia"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "M&#46;C&#46; Weijmer"
                            1 => "H&#46; Neering"
                            2 => "C&#46; Welten"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Lancet"
                        "fecha" => "1990"
                        "volumen" => "336"
                        "paginaInicial" => "464"
                        "paginaFinal" => "466"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/1974991"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            4 => array:3 [
              "identificador" => "bib0055"
              "etiqueta" => "5"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Vitamin A deficiency and bowel-associated dermatosis-arthritis syndrome secondary to biliopancreatic diversion for obesity"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "E&#46; G&#243;mez-Diez"
                            1 => "A&#46; Mas Vidal"
                            2 => "T&#46; Soler"
                            3 => "F&#46; V&#225;zquez-L&#243;pez"
                            4 => "N&#46; P&#233;rez Oliva"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Actas Dermosifiliogr"
                        "fecha" => "2010"
                        "volumen" => "101"
                        "paginaInicial" => "900"
                        "paginaFinal" => "902"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/21159272"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            5 => array:3 [
              "identificador" => "bib0060"
              "etiqueta" => "6"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Acrodermatitis due to zinc deficiency after combined vertical gastroplasty with jejunoileal bypass&#58; Case report"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "S&#46;F&#46; Cunha"
                            1 => "G&#46;A&#46; Gon&#231;alves"
                            2 => "J&#46;S&#46; Marchini"
                            3 => "A&#46;M&#46; Roselino"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Sao Paulo Med J"
                        "fecha" => "2012"
                        "volumen" => "130"
                        "paginaInicial" => "330"
                        "paginaFinal" => "335"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/23174873"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
          ]
        ]
      ]
    ]
  ]
  "idiomaDefecto" => "en"
  "url" => "/15782190/0000010600000004/v2_201505051007/S157821901500061X/v2_201505051007/en/main.assets"
  "Apartado" => array:4 [
    "identificador" => "6157"
    "tipo" => "SECCION"
    "en" => array:2 [
      "titulo" => "Case and Research Letters"
      "idiomaDefecto" => true
    ]
    "idiomaDefecto" => "en"
  ]
  "PDF" => "https://static.elsevier.es/multimedia/15782190/0000010600000004/v2_201505051007/S157821901500061X/v2_201505051007/en/main.pdf?idApp=UINPBA000044&text.app=https://actasdermo.org/"
  "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S157821901500061X?idApp=UINPBA000044"
]
Compartir
Información de la revista

Estadísticas

Siga este enlace para acceder al texto completo del artículo

Case and Research Letter
Phrynoderma After Biliopancreatic Diversion
Frinoderma asociado a derivación biliopancreática
L. Abada,
Autor para correspondencia
laura.abad.polo@gmail.com

Corresponding author.
, T. Omisteb, J. Verac, Y. Gilaberted
a Medicina de Familia y Comunitaria, Hospital San Jorge, Huesca, Spain
b Servicio de Medicina Interna, Hospital San Jorge, Huesca, Spain
c Servicio de Anatomía Patológica, Hospital San Jorge, Huesca, Spain
d Servicio de Dermatología, Hospital San Jorge, Huesca, Spain
Leído
6530
Veces
se ha leído el artículo
1958
Total PDF
4572
Total HTML
Compartir estadísticas
 array:23 [
  "pii" => "S157821901500061X"
  "issn" => "15782190"
  "doi" => "10.1016/j.adengl.2015.03.011"
  "estado" => "S300"
  "fechaPublicacion" => "2015-05-01"
  "aid" => "1065"
  "copyright" => "Elsevier Espa&#241;a&#44; S&#46;L&#46;U&#46; and AEDV"
  "copyrightAnyo" => "2014"
  "documento" => "simple-article"
  "subdocumento" => "cor"
  "cita" => "Actas Dermosifiliogr. 2015;106:327-9"
  "abierto" => array:3 [
    "ES" => true
    "ES2" => true
    "LATM" => true
  ]
  "gratuito" => true
  "lecturas" => array:2 [
    "total" => 1153
    "formatos" => array:3 [
      "EPUB" => 51
      "HTML" => 829
      "PDF" => 273
    ]
  ]
  "Traduccion" => array:1 [
    "es" => array:18 [
      "pii" => "S0001731014004499"
      "issn" => "00017310"
      "doi" => "10.1016/j.ad.2014.08.009"
      "estado" => "S300"
      "fechaPublicacion" => "2015-05-01"
      "aid" => "1065"
      "copyright" => "Elsevier Espa&#241;a&#44; S&#46;L&#46;U&#46; y AEDV"
      "documento" => "simple-article"
      "subdocumento" => "cor"
      "cita" => "Actas Dermosifiliogr. 2015;106:327-9"
      "abierto" => array:3 [
        "ES" => true
        "ES2" => true
        "LATM" => true
      ]
      "gratuito" => true
      "lecturas" => array:2 [
        "total" => 1485
        "formatos" => array:3 [
          "EPUB" => 3
          "HTML" => 886
          "PDF" => 596
        ]
      ]
      "es" => array:11 [
        "idiomaDefecto" => true
        "cabecera" => "<span class="elsevierStyleTextfn">Carta cient&#237;fico-cl&#237;nica</span>"
        "titulo" => "Frinoderma asociado a derivaci&#243;n biliopancre&#225;tica"
        "tienePdf" => "es"
        "tieneTextoCompleto" => "es"
        "paginas" => array:1 [
          0 => array:2 [
            "paginaInicial" => "327"
            "paginaFinal" => "329"
          ]
        ]
        "titulosAlternativos" => array:1 [
          "en" => array:1 [
            "titulo" => "Phrynoderma After Biliopancreatic Diversion"
          ]
        ]
        "contieneTextoCompleto" => array:1 [
          "es" => true
        ]
        "contienePdf" => array:1 [
          "es" => true
        ]
        "resumenGrafico" => array:2 [
          "original" => 0
          "multimedia" => array:7 [
            "identificador" => "fig0010"
            "etiqueta" => "Figura 2"
            "tipo" => "MULTIMEDIAFIGURA"
            "mostrarFloat" => true
            "mostrarDisplay" => false
            "figura" => array:1 [
              0 => array:4 [
                "imagen" => "gr2.jpeg"
                "Alto" => 741
                "Ancho" => 990
                "Tamanyo" => 253122
              ]
            ]
            "descripcion" => array:1 [
              "es" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Dilataci&#243;n de los infund&#237;bulos foliculares con tapones querat&#243;sicos centrales &#40;H-E&#44; 20x&#41;&#46;</p>"
            ]
          ]
        ]
        "autores" => array:1 [
          0 => array:2 [
            "autoresLista" => "L&#46; Abad, T&#46; Omiste, J&#46; Vera, Y&#46; Gilaberte"
            "autores" => array:4 [
              0 => array:2 [
                "nombre" => "L&#46;"
                "apellidos" => "Abad"
              ]
              1 => array:2 [
                "nombre" => "T&#46;"
                "apellidos" => "Omiste"
              ]
              2 => array:2 [
                "nombre" => "J&#46;"
                "apellidos" => "Vera"
              ]
              3 => array:2 [
                "nombre" => "Y&#46;"
                "apellidos" => "Gilaberte"
              ]
            ]
          ]
        ]
      ]
      "idiomaDefecto" => "es"
      "Traduccion" => array:1 [
        "en" => array:9 [
          "pii" => "S157821901500061X"
          "doi" => "10.1016/j.adengl.2015.03.011"
          "estado" => "S300"
          "subdocumento" => ""
          "abierto" => array:3 [
            "ES" => true
            "ES2" => true
            "LATM" => true
          ]
          "gratuito" => true
          "lecturas" => array:1 [
            "total" => 0
          ]
          "idiomaDefecto" => "en"
          "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S157821901500061X?idApp=UINPBA000044"
        ]
      ]
      "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0001731014004499?idApp=UINPBA000044"
      "url" => "/00017310/0000010600000004/v2_201505051016/S0001731014004499/v2_201505051016/es/main.assets"
    ]
  ]
  "itemSiguiente" => array:18 [
    "pii" => "S1578219015000621"
    "issn" => "15782190"
    "doi" => "10.1016/j.adengl.2015.03.012"
    "estado" => "S300"
    "fechaPublicacion" => "2015-05-01"
    "aid" => "1066"
    "copyright" => "Elsevier Espa&#241;a&#44; S&#46;L&#46;U&#46; and AEDV"
    "documento" => "simple-article"
    "subdocumento" => "cor"
    "cita" => "Actas Dermosifiliogr. 2015;106:329-31"
    "abierto" => array:3 [
      "ES" => true
      "ES2" => true
      "LATM" => true
    ]
    "gratuito" => true
    "lecturas" => array:2 [
      "total" => 1532
      "formatos" => array:3 [
        "EPUB" => 53
        "HTML" => 1252
        "PDF" => 227
      ]
    ]
    "en" => array:11 [
      "idiomaDefecto" => true
      "cabecera" => "<span class="elsevierStyleTextfn">Case and Research Letter</span>"
      "titulo" => "Herpes Zoster in Children Vaccinated Against Varicella-Zoster Virus&#58; Experience in our Hospital"
      "tienePdf" => "en"
      "tieneTextoCompleto" => "en"
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "329"
          "paginaFinal" => "331"
        ]
      ]
      "titulosAlternativos" => array:1 [
        "es" => array:1 [
          "titulo" => "Herpes z&#243;ster en ni&#241;os vacunados contra el virus varicela z&#243;ster&#58; experiencia en nuestro hospital"
        ]
      ]
      "contieneTextoCompleto" => array:1 [
        "en" => true
      ]
      "contienePdf" => array:1 [
        "en" => true
      ]
      "resumenGrafico" => array:2 [
        "original" => 0
        "multimedia" => array:7 [
          "identificador" => "fig0005"
          "etiqueta" => "Figure 1"
          "tipo" => "MULTIMEDIAFIGURA"
          "mostrarFloat" => true
          "mostrarDisplay" => false
          "figura" => array:1 [
            0 => array:4 [
              "imagen" => "gr1.jpeg"
              "Alto" => 884
              "Ancho" => 1600
              "Tamanyo" => 182550
            ]
          ]
          "descripcion" => array:1 [
            "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Clinical characteristics of the herpes zoster lesions in 4 of the patients in our series&#46;</p>"
          ]
        ]
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "D&#46; Caro-Guti&#233;rrez, J&#46;L&#46; L&#243;pez-Estebaranz, E&#46; Naz-Villalba, L&#46; Ayala-Bernaldo de Quiros"
          "autores" => array:4 [
            0 => array:2 [
              "nombre" => "D&#46;"
              "apellidos" => "Caro-Guti&#233;rrez"
            ]
            1 => array:2 [
              "nombre" => "J&#46;L&#46;"
              "apellidos" => "L&#243;pez-Estebaranz"
            ]
            2 => array:2 [
              "nombre" => "E&#46;"
              "apellidos" => "Naz-Villalba"
            ]
            3 => array:2 [
              "nombre" => "L&#46;"
              "apellidos" => "Ayala-Bernaldo de Quiros"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "en"
    "Traduccion" => array:1 [
      "es" => array:9 [
        "pii" => "S0001731014004505"
        "doi" => "10.1016/j.ad.2014.07.007"
        "estado" => "S300"
        "subdocumento" => ""
        "abierto" => array:3 [
          "ES" => true
          "ES2" => true
          "LATM" => true
        ]
        "gratuito" => true
        "lecturas" => array:1 [
          "total" => 0
        ]
        "idiomaDefecto" => "es"
        "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0001731014004505?idApp=UINPBA000044"
      ]
    ]
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1578219015000621?idApp=UINPBA000044"
    "url" => "/15782190/0000010600000004/v2_201505051007/S1578219015000621/v2_201505051007/en/main.assets"
  ]
  "itemAnterior" => array:18 [
    "pii" => "S1578219015000608"
    "issn" => "15782190"
    "doi" => "10.1016/j.adengl.2015.03.010"
    "estado" => "S300"
    "fechaPublicacion" => "2015-05-01"
    "aid" => "1060"
    "copyright" => "Elsevier Espa&#241;a&#44; S&#46;L&#46;U&#46; and AEDV"
    "documento" => "simple-article"
    "subdocumento" => "cor"
    "cita" => "Actas Dermosifiliogr. 2015;106:326-7"
    "abierto" => array:3 [
      "ES" => true
      "ES2" => true
      "LATM" => true
    ]
    "gratuito" => true
    "lecturas" => array:2 [
      "total" => 1080
      "formatos" => array:3 [
        "EPUB" => 47
        "HTML" => 603
        "PDF" => 430
      ]
    ]
    "en" => array:10 [
      "idiomaDefecto" => true
      "cabecera" => "<span class="elsevierStyleTextfn">Case and Research letter</span>"
      "titulo" => "Gastric Mucosa-Associated Lymphoid Tissue Lymphoma in a Patient With Severe Psoriasis Receiving Ustekinumab"
      "tienePdf" => "en"
      "tieneTextoCompleto" => "en"
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "326"
          "paginaFinal" => "327"
        ]
      ]
      "titulosAlternativos" => array:1 [
        "es" => array:1 [
          "titulo" => "Linfoma g&#225;strico de tejido linfoide asociado a mucosa en un paciente con psoriasis grave en tratamiento con ustekinumab"
        ]
      ]
      "contieneTextoCompleto" => array:1 [
        "en" => true
      ]
      "contienePdf" => array:1 [
        "en" => true
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "J&#46; Gonz&#225;lez-Ramos, M&#46;L&#46; Alonso-Pacheco, A&#46; Mayor-Ibarguren, P&#46; Herranz-Pinto"
          "autores" => array:4 [
            0 => array:2 [
              "nombre" => "J&#46;"
              "apellidos" => "Gonz&#225;lez-Ramos"
            ]
            1 => array:2 [
              "nombre" => "M&#46;L&#46;"
              "apellidos" => "Alonso-Pacheco"
            ]
            2 => array:2 [
              "nombre" => "A&#46;"
              "apellidos" => "Mayor-Ibarguren"
            ]
            3 => array:2 [
              "nombre" => "P&#46;"
              "apellidos" => "Herranz-Pinto"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "en"
    "Traduccion" => array:1 [
      "es" => array:9 [
        "pii" => "S0001731014004190"
        "doi" => "10.1016/j.ad.2014.05.010"
        "estado" => "S300"
        "subdocumento" => ""
        "abierto" => array:3 [
          "ES" => true
          "ES2" => true
          "LATM" => true
        ]
        "gratuito" => true
        "lecturas" => array:1 [
          "total" => 0
        ]
        "idiomaDefecto" => "es"
        "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0001731014004190?idApp=UINPBA000044"
      ]
    ]
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1578219015000608?idApp=UINPBA000044"
    "url" => "/15782190/0000010600000004/v2_201505051007/S1578219015000608/v2_201505051007/en/main.assets"
  ]
  "en" => array:14 [
    "idiomaDefecto" => true
    "cabecera" => "<span class="elsevierStyleTextfn">Case and Research Letter</span>"
    "titulo" => "Phrynoderma After Biliopancreatic Diversion"
    "tieneTextoCompleto" => true
    "paginas" => array:1 [
      0 => array:2 [
        "paginaInicial" => "327"
        "paginaFinal" => "329"
      ]
    ]
    "autores" => array:1 [
      0 => array:4 [
        "autoresLista" => "L&#46; Abad, T&#46; Omiste, J&#46; Vera, Y&#46; Gilaberte"
        "autores" => array:4 [
          0 => array:4 [
            "nombre" => "L&#46;"
            "apellidos" => "Abad"
            "email" => array:1 [
              0 => "laura&#46;abad&#46;polo&#64;gmail&#46;com"
            ]
            "referencia" => array:2 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">a</span>"
                "identificador" => "aff0005"
              ]
              1 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">&#42;</span>"
                "identificador" => "cor0005"
              ]
            ]
          ]
          1 => array:3 [
            "nombre" => "T&#46;"
            "apellidos" => "Omiste"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">b</span>"
                "identificador" => "aff0010"
              ]
            ]
          ]
          2 => array:3 [
            "nombre" => "J&#46;"
            "apellidos" => "Vera"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">c</span>"
                "identificador" => "aff0015"
              ]
            ]
          ]
          3 => array:3 [
            "nombre" => "Y&#46;"
            "apellidos" => "Gilaberte"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">d</span>"
                "identificador" => "aff0020"
              ]
            ]
          ]
        ]
        "afiliaciones" => array:4 [
          0 => array:3 [
            "entidad" => "Medicina de Familia y Comunitaria&#44; Hospital San Jorge&#44; Huesca&#44; Spain"
            "etiqueta" => "a"
            "identificador" => "aff0005"
          ]
          1 => array:3 [
            "entidad" => "Servicio de Medicina Interna&#44; Hospital San Jorge&#44; Huesca&#44; Spain"
            "etiqueta" => "b"
            "identificador" => "aff0010"
          ]
          2 => array:3 [
            "entidad" => "Servicio de Anatom&#237;a Patol&#243;gica&#44; Hospital San Jorge&#44; Huesca&#44; Spain"
            "etiqueta" => "c"
            "identificador" => "aff0015"
          ]
          3 => array:3 [
            "entidad" => "Servicio de Dermatolog&#237;a&#44; Hospital San Jorge&#44; Huesca&#44; Spain"
            "etiqueta" => "d"
            "identificador" => "aff0020"
          ]
        ]
        "correspondencia" => array:1 [
          0 => array:3 [
            "identificador" => "cor0005"
            "etiqueta" => "&#8270;"
            "correspondencia" => "Corresponding author&#46;"
          ]
        ]
      ]
    ]
    "titulosAlternativos" => array:1 [
      "es" => array:1 [
        "titulo" => "Frinoderma asociado a derivaci&#243;n biliopancre&#225;tica"
      ]
    ]
    "resumenGrafico" => array:2 [
      "original" => 0
      "multimedia" => array:7 [
        "identificador" => "fig0005"
        "etiqueta" => "Figure 1"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr1.jpeg"
            "Alto" => 598
            "Ancho" => 1600
            "Tamanyo" => 180795
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">A&#44; Violaceous&#44; suppurating papular and tuberose lesions&#44; some with scabs&#46; B&#44; Resolution of the phrynoderma lesions&#46;</p>"
        ]
      ]
    ]
    "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">Current surgical techniques for the treatment of morbid obesity can lead to major systemic complications&#46; Biliopancreatic bypass surgery is a mixed restrictive-malabsorptive type of bariatric surgery that combines partial gastrectomy with a gastroileal anastomosis&#44; causing the bile and pancreatic secretions to mix with the foods only in the final 50<span class="elsevierStyleHsp" style=""></span>cm of the small bowel&#46; In the long term&#44; this considerably reduces the absorption of vitamins&#44; oligoelements&#44; and essential fatty acids&#46;</p><p id="par0010" class="elsevierStylePara elsevierViewall">Our patient was a man of 46 years of age&#44; with a history of obesity&#44; hypertension&#44; tuberculous lymphadenitis in 2005&#44; a biliopancreatic bypass operation in 1999&#44; and operations for an anal fistula and to perform dermolipectomy in the hypogastrium and flanks&#46; He was on treatment with valsartan&#44; venotonic agents&#44; ferrous sulfate&#44; and Dayamineral &#40;a vitamin and mineral supplement&#41;&#46; He was seen in dermatology in 2012 for suppurating lesions on the lower limbs&#46; The lesions had appeared when he started to lose weight after the bariatric surgery and they had gradually spread to the trunk and upper limbs&#46; The diagnoses from 2 skin biopsies performed in 2003 were folliculitis and furuncle&#44; respectively&#46; Cultures for bacteria&#44; fungi&#44; and mycobacteria were repeatedly negative and various oral antibiotic treatments did not resolve the condition&#46; On physical examination there were violaceous papular and tuberose lesions&#44; some with scabs&#44; situated mainly on the thighs and on the medial aspect of the knees&#44; but with isolated lesions on the abdomen and on the proximal areas of the upper limbs &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>A&#41;&#46; Histopathology revealed the presence of intense hyperkeratosis in the pilosebaceous follicles&#44; giving rise to the formation of keratin cysts&#46; There was also a small abscess with residues of fragmented collagen and the presence of macrophages and neutrophils &#40;<a class="elsevierStyleCrossRef" href="#fig0010">Fig&#46; 2</a>&#41;&#46; No fragmentation of elastic fibers was detected&#46; Special techniques did not reveal the presence of fungi or of mycobacteria&#46; A provisional diagnosis of phrynoderma was made based on these findings&#46; Blood tests confirmed the deficit of vitamin A &#40;0&#46;15<span class="elsevierStyleHsp" style=""></span>mg&#47;L &#91;normal range&#44; 0&#46;30-1<span class="elsevierStyleHsp" style=""></span>mg&#47;L&#93;&#41;&#44; as well as of vitamin E &#40;4&#46;9<span class="elsevierStyleHsp" style=""></span>&#956;g&#47;mL &#91;normal range&#44; 5-20<span class="elsevierStyleHsp" style=""></span>&#956;g&#47;mL&#93;&#41;&#44; Vitamin D<span class="elsevierStyleInf">3</span> &#40;14&#46;18<span class="elsevierStyleHsp" style=""></span>ng&#47;mL &#91;normal range&#44; 20-32<span class="elsevierStyleHsp" style=""></span>ng&#47;mL&#93;&#41;&#44; and zinc &#40;43<span class="elsevierStyleHsp" style=""></span>&#956;g&#47;dL&#41;&#44; as well as a low hemoglobin level &#40;11&#46;4<span class="elsevierStyleHsp" style=""></span>g&#47;dL&#41; and low hematocrit 34&#37;&#46; Oral treatment was therefore prescribed as follows&#58; vitamin A &#40;1000<span class="elsevierStyleHsp" style=""></span>IU&#47;d&#41;&#59; vitamin E &#40;20<span class="elsevierStyleHsp" style=""></span>mg&#47;d&#41;&#59; calcifediol &#40;1 ampoule of 3<span class="elsevierStyleHsp" style=""></span>mg&#47;1&#46;5<span class="elsevierStyleHsp" style=""></span>mL per week&#41;&#59; Hidroxil-B<span class="elsevierStyleInf">12</span>-B<span class="elsevierStyleInf">6</span>-B<span class="elsevierStyleInf">1</span>&#59; Dayamineral&#44; 1 tablet once a day&#59; ferrous iron &#40;80<span class="elsevierStyleHsp" style=""></span>mg&#47;d&#41;&#59; and oil rich in medium-chain triglycerides&#46; After 7 months of treatment the skin lesions had not improved and the serum levels of vitamin A &#40;0&#46;11<span class="elsevierStyleHsp" style=""></span>mg&#47;L&#41; and vitamin E &#40;5&#46;1<span class="elsevierStyleHsp" style=""></span>&#956;g&#47;mL&#41;&#44; Zn &#40;52<span class="elsevierStyleHsp" style=""></span>&#956;g&#47;dL&#41;&#44; the hemoglobin level &#40;11&#46;0<span class="elsevierStyleHsp" style=""></span>g&#47;dL&#41;&#44; and the hematocrit 33&#37; were still low&#46; Intravenous iron &#40;500<span class="elsevierStyleHsp" style=""></span>mg of iron&#41;&#44; intramuscular vitamin A &#40;100&#160;000<span class="elsevierStyleHsp" style=""></span>IU&#47;mo&#41; and zinc sulfate &#40;22&#46;5<span class="elsevierStyleHsp" style=""></span>mg&#47;d&#41; were therefore added to the patient&#39;s treatment&#46; Three months later the vitamin levels were normal &#40;vitamin A&#44; 0&#46;38<span class="elsevierStyleHsp" style=""></span>mg&#47;L&#41;&#44; the anemia had resolved&#44; and only residual areas of hyperpigmentation were present on the skin &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>B&#41;&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><elsevierMultimedia ident="fig0010"></elsevierMultimedia><p id="par0015" class="elsevierStylePara elsevierViewall">Phrynoderma is the characteristic dermatosis associated with a deficiency of vitamin A&#44; a fat-soluble vitamin involved in numerous body functions&#46; Although this vitamin deficiency is common in Africa and southeast Asia&#44; phrynoderma is rare in Spain&#44; where it is associated with malabsorptive states&#44; such as pancreatic insufficiency&#44; colectomy&#44; and chronic giardiasis&#44; or arises as a complication of bariatric surgery&#46;<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">1</span></a></p><p id="par0020" class="elsevierStylePara elsevierViewall">Vitamin A deficiency is very common among patients who have undergone bariatric surgery and it has been associated with low prealbumin levels&#44; leading to a suggestion to use vitamin A levels as a marker of protein-energy malnutrition in these patients&#46;<a class="elsevierStyleCrossRef" href="#bib0040"><span class="elsevierStyleSup">2</span></a></p><p id="par0025" class="elsevierStylePara elsevierViewall">Phrynoderma is characterized by the presence of follicular hyperkeratosis&#44; mainly affecting the extensor surfaces of the limbs&#44; the abdomen&#44; and back&#46; It is often associated with xerosis and hyperpigmentation&#44; as well as extracutaneous manifestations such as night blindness&#46; The majority of reports of phrynoderma secondary to biliopancreatic bypass surgery describe atypical lesions that are larger and more inflammatory and tend to arise in atypical sites&#44; as occurred in our patient&#46;<a class="elsevierStyleCrossRef" href="#bib0045"><span class="elsevierStyleSup">3</span></a> Deficits of many other essential oligoelements and vitamins observed in these patients may contribute to this atypical presentation&#44; particularly if we consider that phrynoderma does not appear to have a single etiology&#46;<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">1</span></a> For example&#44; furunculosis has been described in association with iron deficiency and has improved after restoring normal iron levels<a class="elsevierStyleCrossRef" href="#bib0050"><span class="elsevierStyleSup">4</span></a>&#59; this diagnosis had to be considered in our patient as the first biopsies were compatible with this skin disorder&#46;</p><p id="par0030" class="elsevierStylePara elsevierViewall">From a clinical point of view&#44; the differential diagnosis must include other skin conditions that have been described in association with bariatric surgery&#44; such as dermatosis-arthritis syndrome&#44; neutrophilic dermatosis attributed to the formation of circulating immune complexes produced in the blind loop of bowel&#44;<a class="elsevierStyleCrossRef" href="#bib0055"><span class="elsevierStyleSup">5</span></a> and acrodermatitis related to zinc deficiency&#46;<a class="elsevierStyleCrossRef" href="#bib0060"><span class="elsevierStyleSup">6</span></a> We also considered the perforating dermatoses&#44; although no association with bariatric surgery has been reported&#46;</p><p id="par0035" class="elsevierStylePara elsevierViewall">The increase in obesity in western society means that bariatric surgery will become more common&#46; The conclusion from the present case is that patients undergoing bariatric surgery must be followed up closely by a multidisciplinary team that is aware of the nutritional risks and complications&#44; as well as the appropriate therapeutic strategies that patients must follow for life&#46;</p></span>"
    "pdfFichero" => "main.pdf"
    "tienePdf" => true
    "NotaPie" => array:1 [
      0 => array:2 [
        "etiqueta" => "&#9734;"
        "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Please cite this article as&#58; Abad L&#44; Omiste T&#44; Vera J&#44; Gilaberte Y&#46; Frinoderma asociado a derivaci&#243;n biliopancre&#225;tica&#46; Actas Dermosifiliogr&#46; 2015&#59;106&#58;327&#8211;329&#46;</p>"
      ]
    ]
    "multimedia" => array:2 [
      0 => array:7 [
        "identificador" => "fig0005"
        "etiqueta" => "Figure 1"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr1.jpeg"
            "Alto" => 598
            "Ancho" => 1600
            "Tamanyo" => 180795
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">A&#44; Violaceous&#44; suppurating papular and tuberose lesions&#44; some with scabs&#46; B&#44; Resolution of the phrynoderma lesions&#46;</p>"
        ]
      ]
      1 => array:7 [
        "identificador" => "fig0010"
        "etiqueta" => "Figure 2"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr2.jpeg"
            "Alto" => 741
            "Ancho" => 990
            "Tamanyo" => 257745
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Dilation of the follicular infundibulum with central keratotic plugs &#40;hematoxylin and eosin&#44; original magnification x<span class="elsevierStyleHsp" style=""></span>20&#41;&#46;</p>"
        ]
      ]
    ]
    "bibliografia" => array:2 [
      "titulo" => "References"
      "seccion" => array:1 [
        0 => array:2 [
          "identificador" => "bibs0005"
          "bibliografiaReferencia" => array:6 [
            0 => array:3 [
              "identificador" => "bib0035"
              "etiqueta" => "1"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Biliopancreatic diversion&#58; When a cure becomes a disease"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "C&#46; Panetta"
                            1 => "G&#46; Polino"
                            2 => "L&#46; Muscardin"
                            3 => "M&#46; Donati"
                            4 => "P&#46; Danati"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1097/DAD.0b013e3182926665"
                      "Revista" => array:6 [
                        "tituloSerie" => "Am J Dermatopathol"
                        "fecha" => "2014"
                        "volumen" => "36"
                        "paginaInicial" => "258"
                        "paginaFinal" => "259"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/23719482"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            1 => array:3 [
              "identificador" => "bib0040"
              "etiqueta" => "2"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Vitamin A deficiency after gastric bypass surgery&#58; An underreported postoperative complication"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "K&#46;C&#46; Zalesin"
                            1 => "W&#46;M&#46; Miller"
                            2 => "B&#46; Franklin"
                            3 => "D&#46; Mudugal"
                            4 => "A&#46; Rao Buragadda"
                            5 => "K&#46; Nori-Janosz"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:3 [
                        "tituloSerie" => "J Obes"
                        "fecha" => "2011"
                        "paginaInicial" => "2011"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            2 => array:3 [
              "identificador" => "bib0045"
              "etiqueta" => "3"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Frinoderma secundario a d&#233;ficit de vitamina A en un paciente con derivaci&#243;n biliopancre&#225;tica"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "J&#46; Oc&#243;n Bret&#243;n"
                            1 => "M&#46; Cabrejas G&#243;mez"
                            2 => "J&#46; Altemir Trallero"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1590/S0212-16112011000200027"
                      "Revista" => array:6 [
                        "tituloSerie" => "Nutr Hosp"
                        "fecha" => "2011"
                        "volumen" => "26"
                        "paginaInicial" => "421"
                        "paginaFinal" => "424"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/21666984"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            3 => array:3 [
              "identificador" => "bib0050"
              "etiqueta" => "4"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Preliminary report&#58; Furunculosis and hypoferraemia"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "M&#46;C&#46; Weijmer"
                            1 => "H&#46; Neering"
                            2 => "C&#46; Welten"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Lancet"
                        "fecha" => "1990"
                        "volumen" => "336"
                        "paginaInicial" => "464"
                        "paginaFinal" => "466"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/1974991"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            4 => array:3 [
              "identificador" => "bib0055"
              "etiqueta" => "5"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Vitamin A deficiency and bowel-associated dermatosis-arthritis syndrome secondary to biliopancreatic diversion for obesity"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "E&#46; G&#243;mez-Diez"
                            1 => "A&#46; Mas Vidal"
                            2 => "T&#46; Soler"
                            3 => "F&#46; V&#225;zquez-L&#243;pez"
                            4 => "N&#46; P&#233;rez Oliva"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Actas Dermosifiliogr"
                        "fecha" => "2010"
                        "volumen" => "101"
                        "paginaInicial" => "900"
                        "paginaFinal" => "902"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/21159272"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            5 => array:3 [
              "identificador" => "bib0060"
              "etiqueta" => "6"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Acrodermatitis due to zinc deficiency after combined vertical gastroplasty with jejunoileal bypass&#58; Case report"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "S&#46;F&#46; Cunha"
                            1 => "G&#46;A&#46; Gon&#231;alves"
                            2 => "J&#46;S&#46; Marchini"
                            3 => "A&#46;M&#46; Roselino"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Sao Paulo Med J"
                        "fecha" => "2012"
                        "volumen" => "130"
                        "paginaInicial" => "330"
                        "paginaFinal" => "335"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/23174873"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
          ]
        ]
      ]
    ]
  ]
  "idiomaDefecto" => "en"
  "url" => "/15782190/0000010600000004/v2_201505051007/S157821901500061X/v2_201505051007/en/main.assets"
  "Apartado" => array:4 [
    "identificador" => "6157"
    "tipo" => "SECCION"
    "en" => array:2 [
      "titulo" => "Case and Research Letters"
      "idiomaDefecto" => true
    ]
    "idiomaDefecto" => "en"
  ]
  "PDF" => "https://static.elsevier.es/multimedia/15782190/0000010600000004/v2_201505051007/S157821901500061X/v2_201505051007/en/main.pdf?idApp=UINPBA000044&text.app=https://actasdermo.org/"
  "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S157821901500061X?idApp=UINPBA000044"
]
Información del artículo
ISSN: 15782190
Idioma original: Inglés
Datos actualizados diariamente
año/Mes Html Pdf Total
2024 Noviembre 5 9 14
2024 Octubre 88 39 127
2024 Septiembre 97 18 115
2024 Agosto 96 69 165
2024 Julio 102 37 139
2024 Junio 96 34 130
2024 Mayo 78 28 106
2024 Abril 77 27 104
2024 Marzo 94 32 126
2024 Febrero 68 28 96
2024 Enero 68 36 104
2023 Diciembre 99 20 119
2023 Noviembre 91 19 110
2023 Octubre 86 19 105
2023 Septiembre 76 23 99
2023 Agosto 63 20 83
2023 Julio 77 28 105
2023 Junio 61 23 84
2023 Mayo 93 23 116
2023 Abril 95 18 113
2023 Marzo 67 32 99
2023 Febrero 66 31 97
2023 Enero 58 36 94
2022 Diciembre 62 63 125
2022 Noviembre 38 27 65
2022 Octubre 36 22 58
2022 Septiembre 32 46 78
2022 Agosto 32 29 61
2022 Julio 32 29 61
2022 Junio 27 21 48
2022 Mayo 70 36 106
2022 Abril 86 40 126
2022 Marzo 62 51 113
2022 Febrero 61 21 82
2022 Enero 70 34 104
2021 Diciembre 35 27 62
2021 Noviembre 58 45 103
2021 Octubre 56 45 101
2021 Septiembre 67 39 106
2021 Agosto 41 48 89
2021 Julio 35 59 94
2021 Junio 56 35 91
2021 Mayo 41 28 69
2021 Abril 271 39 310
2021 Marzo 114 15 129
2021 Febrero 93 32 125
2021 Enero 60 18 78
2020 Diciembre 52 19 71
2020 Noviembre 36 18 54
2020 Octubre 53 14 67
2020 Septiembre 54 13 67
2020 Agosto 25 18 43
2020 Julio 31 16 47
2020 Junio 39 28 67
2020 Mayo 31 20 51
2020 Abril 49 20 69
2020 Marzo 32 18 50
2020 Febrero 6 3 9
2020 Enero 1 0 1
2019 Diciembre 4 2 6
2019 Octubre 1 0 1
2019 Septiembre 6 3 9
2019 Julio 0 1 1
2019 Junio 2 4 6
2019 Mayo 1 22 23
2019 Abril 0 1 1
2019 Marzo 2 5 7
2019 Febrero 1 1 2
2019 Enero 2 0 2
2018 Diciembre 2 0 2
2018 Octubre 5 0 5
2018 Septiembre 6 0 6
2018 Junio 0 1 1
2018 Mayo 0 3 3
2018 Abril 0 1 1
2018 Marzo 2 1 3
2018 Febrero 46 4 50
2018 Enero 57 6 63
2017 Diciembre 60 8 68
2017 Noviembre 32 3 35
2017 Octubre 36 4 40
2017 Septiembre 34 5 39
2017 Agosto 62 10 72
2017 Julio 43 8 51
2017 Junio 50 13 63
2017 Mayo 45 23 68
2017 Abril 31 8 39
2017 Marzo 25 8 33
2017 Febrero 32 12 44
2017 Enero 18 9 27
2016 Diciembre 26 13 39
2016 Noviembre 34 15 49
2016 Octubre 31 16 47
2016 Septiembre 0 7 7
2016 Agosto 0 1 1
2016 Julio 10 1 11
2016 Junio 9 5 14
2016 Mayo 12 10 22
2016 Abril 9 1 10
2016 Marzo 9 8 17
2016 Febrero 6 4 10
2016 Enero 8 1 9
2015 Diciembre 12 2 14
2015 Noviembre 11 3 14
2015 Octubre 0 2 2
2015 Septiembre 0 1 1
2015 Agosto 0 2 2
2015 Julio 14 6 20
2015 Junio 14 3 17
2015 Mayo 17 6 23
Mostrar todo

Siga este enlace para acceder al texto completo del artículo

Idiomas
Actas Dermo-Sifiliográficas
es en

¿Es usted profesional sanitario apto para prescribir o dispensar medicamentos?

Are you a health professional able to prescribe or dispense drugs?