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array:25 [ "pii" => "S1578219015000207" "issn" => "15782190" "doi" => "10.1016/j.adengl.2015.01.007" "estado" => "S300" "fechaPublicacion" => "2015-04-01" "aid" => "1058" "copyright" => "Elsevier España, S.L.U. and AEDV" "copyrightAnyo" => "2014" "documento" => "simple-article" "crossmark" => 1 "licencia" => "http://creativecommons.org/licenses/by-nc-nd/4.0/" "subdocumento" => "crp" "cita" => "Actas Dermosifiliogr. 2015;106:e13-e17" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:2 [ "total" => 1193 "formatos" => array:3 [ "EPUB" => 54 "HTML" => 695 "PDF" => 444 ] ] "Traduccion" => array:1 [ "es" => array:19 [ "pii" => "S0001731014004177" "issn" => "00017310" "doi" => "10.1016/j.ad.2014.09.002" "estado" => "S300" "fechaPublicacion" => "2015-04-01" "aid" => "1058" "copyright" => "Elsevier España, S.L.U. y AEDV" "documento" => "simple-article" "crossmark" => 1 "subdocumento" => "crp" "cita" => "Actas Dermosifiliogr. 2015;106:e13-e17" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:2 [ "total" => 1094 "formatos" => array:3 [ "EPUB" => 3 "HTML" => 558 "PDF" => 533 ] ] "es" => array:13 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">e-Casos clínicos</span>" "titulo" => "Melanoma primario cutáneo angiomatoide. Un patrón morfológico excepcional en los melanomas de piel. Presentación de caso con revisión de la literatura" "tienePdf" => "es" "tieneTextoCompleto" => "es" "tieneResumen" => array:2 [ 0 => "es" 1 => "en" ] "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "e13" "paginaFinal" => "e17" ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "Primary Angiomatoid Melanoma as an Exceptional Morphologic Pattern in Cutaneous Melanoma. A Case Report and Review of the Literature" ] ] "contieneResumen" => array:2 [ "es" => true "en" => true ] "contieneTextoCompleto" => array:1 [ "es" => true ] "contienePdf" => array:1 [ "es" => true ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0005" "etiqueta" => "Figura 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 1347 "Ancho" => 1800 "Tamanyo" => 680942 ] ] "descripcion" => array:1 [ "es" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">A. Imagen panorámica del melanoma angiomatoide (H-E ×<span class="elsevierStyleHsp" style=""></span>100). B y C. Mayor aumento donde se ilustra que los espacios pseudovasculares están revestidos de células neoplásicas y numerosos eritrocitos extravasados (H-E ×<span class="elsevierStyleHsp" style=""></span>200).</p>" ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "G. Ramos-Rodríguez, C. Ortiz-Hidalgo" "autores" => array:2 [ 0 => array:2 [ "nombre" => "G." "apellidos" => "Ramos-Rodríguez" ] 1 => array:2 [ "nombre" => "C." "apellidos" => "Ortiz-Hidalgo" ] ] ] ] ] "idiomaDefecto" => "es" "Traduccion" => array:1 [ "en" => array:9 [ "pii" => "S1578219015000207" "doi" => "10.1016/j.adengl.2015.01.007" "estado" => "S300" "subdocumento" => "" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1578219015000207?idApp=UINPBA000044" ] ] "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0001731014004177?idApp=UINPBA000044" "url" => "/00017310/0000010600000003/v3_202209240525/S0001731014004177/v3_202209240525/es/main.assets" ] ] "itemSiguiente" => array:20 [ "pii" => "S1578219015000219" "issn" => "15782190" "doi" => "10.1016/j.adengl.2015.01.008" "estado" => "S300" "fechaPublicacion" => "2015-04-01" "aid" => "1004" "copyright" => "Elsevier España, S.L.U. and AEDV" "documento" => "simple-article" "crossmark" => 1 "licencia" => "http://creativecommons.org/licenses/by-nc-nd/4.0/" "subdocumento" => "cor" "cita" => "Actas Dermosifiliogr. 2015;106:227-8" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:2 [ "total" => 801 "formatos" => array:3 [ "EPUB" => 55 "HTML" => 576 "PDF" => 170 ] ] "en" => array:11 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Case for Diagnosis</span>" "titulo" => "Mucosal Papules in a 9-Year-Old Girl" "tienePdf" => "en" "tieneTextoCompleto" => "en" "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "227" "paginaFinal" => "228" ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Pápulas mucosas en una niña de 9 años" ] ] "contieneTextoCompleto" => array:1 [ "en" => true ] "contienePdf" => array:1 [ "en" => true ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0010" "etiqueta" => "Figure 2" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr2.jpeg" "Alto" => 1230 "Ancho" => 1651 "Tamanyo" => 646960 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">A, Hematoxylin-eosin, original magnification ×100. B, Hematoxylin-eosin, original magnification ×200. C, Neurofilament immunohistochemistry. D, S100 immunohistochemistry.</p>" ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "L. Padilla-España, J. del Boz-González, M. de Troya Martín" "autores" => array:3 [ 0 => array:2 [ "nombre" => "L." "apellidos" => "Padilla-España" ] 1 => array:2 [ "nombre" => "J." "apellidos" => "del Boz-González" ] 2 => array:2 [ "nombre" => "M." "apellidos" => "de Troya Martín" ] ] ] ] ] "idiomaDefecto" => "en" "Traduccion" => array:1 [ "es" => array:9 [ "pii" => "S0001731014002117" "doi" => "10.1016/j.ad.2014.03.009" "estado" => "S300" "subdocumento" => "" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0001731014002117?idApp=UINPBA000044" ] ] "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1578219015000219?idApp=UINPBA000044" "url" => "/15782190/0000010600000003/v3_202209240641/S1578219015000219/v3_202209240641/en/main.assets" ] "itemAnterior" => array:20 [ "pii" => "S1578219015000190" "issn" => "15782190" "doi" => "10.1016/j.adengl.2015.01.006" "estado" => "S300" "fechaPublicacion" => "2015-04-01" "aid" => "1055" "copyright" => "Elsevier España, S.L.U. and AEDV" "documento" => "article" "crossmark" => 1 "licencia" => "http://creativecommons.org/licenses/by-nc-nd/4.0/" "subdocumento" => "fla" "cita" => "Actas Dermosifiliogr. 2015;106:219-25" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:2 [ "total" => 844 "formatos" => array:3 [ "EPUB" => 49 "HTML" => 607 "PDF" => 188 ] ] "en" => array:13 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Original Article</span>" "titulo" => "Drug Eruptions Induced by Telaprevir in Patients With Chronic Hepatitis C Virus Genotype 1 Infection: A Prospective Study" "tienePdf" => "en" "tieneTextoCompleto" => "en" "tieneResumen" => array:2 [ 0 => "en" 1 => "es" ] "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "219" "paginaFinal" => "225" ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Toxicodermias por telaprevir en el tratamiento de la infección crónica por el genotipo 1 del virus de la hepatitis C. Estudio prospectivo" ] ] "contieneResumen" => array:2 [ "en" => true "es" => true ] "contieneTextoCompleto" => array:1 [ "en" => true ] "contienePdf" => array:1 [ "en" => true ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0005" "etiqueta" => "Figure 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 1170 "Ancho" => 1670 "Tamanyo" => 80110 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0055" class="elsevierStyleSimplePara elsevierViewall">Time of onset of eruptions after initiation of triple therapy.</p>" ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "M. Toro Montecinos, J.M. Carrascosa Carrillo, M. Vilavella Rius, I. Bielsa Marsol, A. Plana Pla, R. Morillas Cunill, R. Planas Vilà, H. Masnou Ridaura, D. López Escartin, C. Ferrándiz Foraster" "autores" => array:10 [ 0 => array:2 [ "nombre" => "M." "apellidos" => "Toro Montecinos" ] 1 => array:2 [ "nombre" => "J.M." "apellidos" => "Carrascosa Carrillo" ] 2 => array:2 [ "nombre" => "M." "apellidos" => "Vilavella Rius" ] 3 => array:2 [ "nombre" => "I." "apellidos" => "Bielsa Marsol" ] 4 => array:2 [ "nombre" => "A." "apellidos" => "Plana Pla" ] 5 => array:2 [ "nombre" => "R." "apellidos" => "Morillas Cunill" ] 6 => array:2 [ "nombre" => "R." "apellidos" => "Planas Vilà" ] 7 => array:2 [ "nombre" => "H." "apellidos" => "Masnou Ridaura" ] 8 => array:2 [ "nombre" => "D." "apellidos" => "López Escartin" ] 9 => array:2 [ "nombre" => "C." "apellidos" => "Ferrándiz Foraster" ] ] ] ] ] "idiomaDefecto" => "en" "Traduccion" => array:1 [ "es" => array:9 [ "pii" => "S0001731014004141" "doi" => "10.1016/j.ad.2014.07.004" "estado" => "S300" "subdocumento" => "" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0001731014004141?idApp=UINPBA000044" ] ] "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1578219015000190?idApp=UINPBA000044" "url" => "/15782190/0000010600000003/v3_202209240641/S1578219015000190/v3_202209240641/en/main.assets" ] "en" => array:20 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">e- Case Report</span>" "titulo" => "Primary Angiomatoid Melanoma as an Exceptional Morphologic Pattern in Cutaneous Melanoma. A Case Report and Review of the Literature" "tieneTextoCompleto" => true "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "e13" "paginaFinal" => "e17" ] ] "autores" => array:1 [ 0 => array:4 [ "autoresLista" => "G. Ramos-Rodríguez, C. Ortiz-Hidalgo" "autores" => array:2 [ 0 => array:3 [ "nombre" => "G." "apellidos" => "Ramos-Rodríguez" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] ] ] 1 => array:4 [ "nombre" => "C." "apellidos" => "Ortiz-Hidalgo" "email" => array:1 [ 0 => "cortiz@abchospital.com" ] "referencia" => array:3 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">c</span>" "identificador" => "aff0015" ] 2 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">*</span>" "identificador" => "cor0005" ] ] ] ] "afiliaciones" => array:3 [ 0 => array:3 [ "entidad" => "Departamento de Anatomía Patológica, Hospital Regional Lic. Adolfo López Mateos ISSSTE, México DF, Mexico" "etiqueta" => "a" "identificador" => "aff0005" ] 1 => array:3 [ "entidad" => "Departamento de Patología Quirúrgica y Molecular, Centro Médico ABC, México DF, Mexico" "etiqueta" => "b" "identificador" => "aff0010" ] 2 => array:3 [ "entidad" => "Departamento de Biología Celular y Tisular, Universidad Panamericana, México DF, Mexico" "etiqueta" => "c" "identificador" => "aff0015" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "⁎" "correspondencia" => "Corresponding author." ] ] ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Melanoma primario cutáneo angiomatoide. Un patrón morfológico excepcional en los melanomas de piel. Presentación de caso con revisión de la literatura" ] ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0015" "etiqueta" => "Figure 3" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr3.jpeg" "Alto" => 2254 "Ancho" => 3001 "Tamanyo" => 1223122 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">A, Immunohistochemical staining with D2-40 (podoplanin). B, S-100 protein. C, MiTF-1 showing positive results for pseudovascular spaces. D, CD31 showing positive results only for small vessels (negative staining for pseudovascular spaces).</p>" ] ] ] "textoCompleto" => "<span class="elsevierStyleSections"><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0025">Introduction</span><p id="par0005" class="elsevierStylePara elsevierViewall">Melanoma has diverse morphologic forms. Among the most common forms are superficial spreading melanoma, nodular melanoma, acral lentiginous melanoma, desmoplastic melanoma, and lentigo maligna melanoma. Some of the rarer forms, which fall into the category of miscellaneous melanomas, are melanomas with rosettes, angiotropic melanoma, animal-type melanoma, myxoid melanoma, chondroid melanoma, osteogenic melanoma, rhabdoid melanoma, follicular melanoma, nevoid melanoma, and angiomatoid melanoma. Angiomatoid melanoma was first described in metaplastic melanomas with clusters of neoplastic cells reminiscent of vascular channels. Immunohistochemically, this variant of melanoma is negative for vascular markers and positive for melanocytic markers. The angiomatoid pattern has been described in just 4 cases of melanoma to date in the English literature. The differential diagnosis is with angiosarcoma and pseudovascular squamous cell carcinoma.<a class="elsevierStyleCrossRef" href="#bib0040"><span class="elsevierStyleSup">1</span></a></p><p id="par0010" class="elsevierStylePara elsevierViewall">We describe a case of primary angiomatoid melanoma on the right thigh of a 59-year-old man, with no evidence of metastasis at the time of diagnosis.</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0030">Case Description</span><p id="par0015" class="elsevierStylePara elsevierViewall">We present the case of a 59-year-old man with a skin lesion on his right thigh. The patient reported that the lesion had been present for several months, but he did not specify the exact time. The clinical diagnosis was “probable hemangioma” and the lesion was completely excised. Histologic examination showed a nodular neoplastic lesion with infiltrating margins in the epidermis, extending into the reticular dermis. The neoplastic cells were medium to large in size and had pronounced pleomorphism, with several cells with irregular nuclei, granular chromatin, prominent nucleoli, and abundant cytoplasm interspersed with smaller cells with hyperchromatic nuclei and amphophilic cytoplasm (<a class="elsevierStyleCrossRef" href="#fig0005">Fig. 1</a>). Also identified was dispersed melanic pigment that was positive with Fontana-Masson stain. There were 2 mitoses in 10 high-power fields (×<span class="elsevierStyleHsp" style=""></span>40). The most striking finding was the presence of large channels with a cavernous vascular appearance filled with erythrocytes and surrounded by neoplastic cells (<a class="elsevierStyleCrossRef" href="#fig0005">Fig. 1</a>). Immunohistochemical staining of the neoplastic cells was positive for S-100 protein, HMB-45, and MiTF-1, and uniformly negative for CD31 (<a class="elsevierStyleCrossRefs" href="#fig0010">Figs. 2 and 3</a>). The cells were also positive for D2-40 (podoplanin) and negative for keratin AE1 and AE3 and p63. The Ki-67 proliferation index was 5% to 10%. Based on the above findings, a diagnosis of angiomatoid nodular melanoma was established, with a Clark level of IV, a Breslow thickness of 1.35<span class="elsevierStyleHsp" style=""></span>mm, absence of vertical growth phase, a moderate lymphocytic infiltrate at the base, no evidence of vascular or perineural invasion, or microsatellitosis, and tumor-free lateral and deep margins.</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><elsevierMultimedia ident="fig0010"></elsevierMultimedia><elsevierMultimedia ident="fig0015"></elsevierMultimedia></span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0035">Comment</span><p id="par0020" class="elsevierStylePara elsevierViewall">Alder et al.<a class="elsevierStyleCrossRef" href="#bib0045"><span class="elsevierStyleSup">2</span></a> published the first description of angiomatoid melanoma in 1997. They reported the case of a 44-year-old man with melanoma metastasis to the forehead skin and sacral vertebra. The origin of the primary tumor was unknown. The metastasis on the forehead showed clusters of cells forming cavernous spaces containing numerous erythrocytes and lined by neoplastic cells that stained positive for HMB-45 and S-100 protein and negative for vascular markers. The authors proposed the name <span class="elsevierStyleItalic">angiomatoid melanoma</span> to describe this variant of melanoma. Three additional cases have since been reported<a class="elsevierStyleCrossRefs" href="#bib0050"><span class="elsevierStyleSup">3,4</span></a> (<a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a>).</p><elsevierMultimedia ident="tbl0005"></elsevierMultimedia><p id="par0025" class="elsevierStylePara elsevierViewall">Pseudovascular spaces have been described in benign pigmented nevi, and attributed to artifacts of tissue processing or trauma during the biopsy procedure.<a class="elsevierStyleCrossRef" href="#bib0060"><span class="elsevierStyleSup">5</span></a> Alterations in elastic fibers and/or collagen in the nevi could reduce the resistance of the dermis to the mechanical stress of the biopsy procedure, leading to the formation of these spaces.<a class="elsevierStyleCrossRef" href="#bib0060"><span class="elsevierStyleSup">5</span></a></p><p id="par0030" class="elsevierStylePara elsevierViewall">In a study of invasive uveal melanomas with pseudovascular spaces, Maniotis et al.<a class="elsevierStyleCrossRef" href="#bib0065"><span class="elsevierStyleSup">6</span></a> demonstrated the absence of endothelial cells by light microscopy, transmission electron microscopy, and immunohistochemistry. They also demonstrated in vitro that metastatic melanoma cells and invasive uveal melanoma cells (unlike normal melanocytes or poorly differentiated melanomas) could generate this pseudovascular growth pattern, and proposed that melanoma cells might undergo genetic reversion to a pluripotent (embryonic-like) genotype. The authors also suggested that melanoma cells could generate pseudovascular changes that would facilitate tumor invasion independently of tumor angiogenesis.</p><p id="par0035" class="elsevierStylePara elsevierViewall">The 4 cases of angiomatoid (pseudovascular) melanoma reported to date have all been characterized by aggressive behavior. The case described herein is the second report of primary cutaneous melanoma with an angiomatoid pattern. The first case was reported by Baron et al.<a class="elsevierStyleCrossRef" href="#bib0050"><span class="elsevierStyleSup">3</span></a> in an 84-year-old man with a desmoplastic melanoma containing areas with an angiomatoid pattern. The melanoma was located in the periorbital region and had recurred several times. At the time of writing, our patient has shown no signs of metastasis.</p><p id="par0040" class="elsevierStylePara elsevierViewall">Diagnosis of angiomatoid melanoma must be confirmed by immunohistochemistry and identification of neoplastic cells with melanocytic markers. The histologic presentation of this variant of melanoma poses numerous challenges and can lead to erroneous pathologic diagnosis as it can be confused with angiosarcoma or pseudovascular squamous cell carcinoma.<a class="elsevierStyleCrossRef" href="#bib0070"><span class="elsevierStyleSup">7</span></a></p></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0040">Conflicts of Interest</span><p id="par0045" class="elsevierStylePara elsevierViewall">The authors declare that they have no conflicts of interest.</p></span></span>" "textoCompletoSecciones" => array:1 [ "secciones" => array:9 [ 0 => array:3 [ "identificador" => "xres1774123" "titulo" => "Abstract" "secciones" => array:1 [ 0 => array:1 [ "identificador" => "abst0005" ] ] ] 1 => array:2 [ "identificador" => "xpalclavsec1558321" "titulo" => "Keywords" ] 2 => array:3 [ "identificador" => "xres1774122" "titulo" => "Resumen" "secciones" => array:1 [ 0 => array:1 [ "identificador" => "abst0010" ] ] ] 3 => array:2 [ "identificador" => "xpalclavsec1558322" "titulo" => "Palabras clave" ] 4 => array:2 [ "identificador" => "sec0005" "titulo" => "Introduction" ] 5 => array:2 [ "identificador" => "sec0010" "titulo" => "Case Description" ] 6 => array:2 [ "identificador" => "sec0015" "titulo" => "Comment" ] 7 => array:2 [ "identificador" => "sec0020" "titulo" => "Conflicts of Interest" ] 8 => array:1 [ "titulo" => "References" ] ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2014-07-31" "fechaAceptado" => "2014-09-10" "PalabrasClave" => array:2 [ "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Keywords" "identificador" => "xpalclavsec1558321" "palabras" => array:4 [ 0 => "Angiomatoid melanoma" 1 => "Human Melanoma Black-45 (HMB-45)" 2 => "Protein S-100" 3 => "Angiosarcoma" ] ] ] "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec1558322" "palabras" => array:4 [ 0 => "Melanoma angiomatoide" 1 => "HMB-45" 2 => "Proteína S-100" 3 => "Angiosarcoma" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "en" => array:2 [ "titulo" => "Abstract" "resumen" => "<span id="abst0005" class="elsevierStyleSection elsevierViewall"><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">We report a case of angiomatoid melanoma on the right thigh of a 59-year-old man. The histologic growth pattern of the tumor mimicked vascular proliferation, and the cells lining the pseudovascular spaces were positive for protein S-100, HMB-45, and MITF-1. The differential diagnosis is with angiosarcoma and pseudovascular adenoid squamous cell carcinoma. The case we present is the fifth reported to date.</p></span>" ] "es" => array:2 [ "titulo" => "Resumen" "resumen" => "<span id="abst0010" class="elsevierStyleSection elsevierViewall"><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Presentamos un caso de melanoma angiomatoide localizado en la piel del muslo derecho en un hombre de 59 años de edad. La neoplasia mostró un patrón de crecimiento semejante a una proliferación vascular donde las células que revestían esos espacios “pseudovasculares” fueron positivas a la proteína S-100, al HMB45 y al MiTF1. El diagnóstico diferencial incluye el angiosarcoma y el carcinoma escamoso pseudovascular. El caso que aquí informamos es el quinto de la literatura mundial.</p></span>" ] ] "NotaPie" => array:1 [ 0 => array:2 [ "etiqueta" => "☆" "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Please cite this article as: Ramos-Rodríguez G, Ortiz-Hidalgo C. Melanoma primario cutáneo angiomatoide. Un patrón morfológico excepcional en los melanomas de piel. Presentación de caso con revisión de la literatura. Actas Dermosifiliogr. 2015;106:e13–e17.</p>" ] ] "multimedia" => array:4 [ 0 => array:7 [ "identificador" => "fig0005" "etiqueta" => "Figure 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 2246 "Ancho" => 3001 "Tamanyo" => 1396797 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">A, Panoramic view of angiomatoid melanoma (hematoxylin-eosin, original magnification ×100). B and C, Higher-magnification view showing the pseudovascular spaces lined with neoplastic cells and numerous extravasated erythrocytes (hematoxylin-eosin, original magnification ×200).</p>" ] ] 1 => array:7 [ "identificador" => "fig0010" "etiqueta" => "Figure 2" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr2.jpeg" "Alto" => 2001 "Ancho" => 3001 "Tamanyo" => 1031642 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">A, Immunohistochemical staining with keratin AE1 and AE3 showing positive results in the epithelium and negative neoplastic cells. B, Immunohistochemical staining with HMB-45, with positivity for neoplastic cells and negativity for the epithelium.</p>" ] ] 2 => array:7 [ "identificador" => "fig0015" "etiqueta" => "Figure 3" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr3.jpeg" "Alto" => 2254 "Ancho" => 3001 "Tamanyo" => 1223122 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">A, Immunohistochemical staining with D2-40 (podoplanin). B, S-100 protein. C, MiTF-1 showing positive results for pseudovascular spaces. D, CD31 showing positive results only for small vessels (negative staining for pseudovascular spaces).</p>" ] ] 3 => array:7 [ "identificador" => "tbl0005" "etiqueta" => "Table 1" "tipo" => "MULTIMEDIATABLA" "mostrarFloat" => true "mostrarDisplay" => false "tabla" => array:1 [ "tablatextoimagen" => array:1 [ 0 => array:1 [ "tabla" => array:1 [ 0 => """ <table border="0" frame="\n \t\t\t\t\tvoid\n \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black"> \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Age, y \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Sex \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Location \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Diagnosis \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Immunohistochemistry \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Reference \t\t\t\t\t\t\n \t\t\t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">1 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">44 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Male \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">1) Intravertebral (S1-S2)2) Forehead \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">1) Melanoma2) Angiomatoid metastatic melanoma \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">1) S-100<span class="elsevierStyleSup">+</span>, HMB-45<span class="elsevierStyleSup">+</span>, vimentin<span class="elsevierStyleSup">+</span>2) S-100<span class="elsevierStyleSup">+</span>, HMB-45<span class="elsevierStyleSup">+</span>, vimentin<span class="elsevierStyleSup">+</span> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><a class="elsevierStyleCrossRef" href="#bib0045"><span class="elsevierStyleSup">2</span></a> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">2 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">84 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Male \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Periorbital region \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Desmoplastic and amelanotic melanoma with an angiomatoid pattern \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">S100<span class="elsevierStyleSup">+</span> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><a class="elsevierStyleCrossRef" href="#bib0050"><span class="elsevierStyleSup">3</span></a> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">3 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">56 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Female \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">1) Right arm2) Back (paravertebral muscles), lower left quadrant of the left breast, neck, subcutaneous tissue (right shoulder, psoas muscle, medial gluteus) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">1) Melanoma, Clark level III, Breslow thickness 1.1<span class="elsevierStyleHsp" style=""></span>mm2) Angiomatoid metastatic melanoma \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">1) S-100<span class="elsevierStyleSup">+</span>, Melan A<span class="elsevierStyleSup">+</span>, HMB-45<span class="elsevierStyleSup">+</span>2) S-100<span class="elsevierStyleSup">+</span>, HMB-45<span class="elsevierStyleSup">+</span>, Melan A<span class="elsevierStyleSup">+</span>, CD56<span class="elsevierStyleSup">+</span> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><a class="elsevierStyleCrossRef" href="#bib0055"><span class="elsevierStyleSup">4</span></a> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">4 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">61 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Male \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">1) Third finger of the left hand2) Axillary lymph node \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">1) Acral lentiginous melanoma, Clark level III, Breslow thickness 0.55<span class="elsevierStyleHsp" style=""></span>mm2) Angiomatoid metastatic melanoma \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">1) S-100<span class="elsevierStyleSup">+</span>2) S-100<span class="elsevierStyleSup">+</span>, CD56<span class="elsevierStyleSup">+</span> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><a class="elsevierStyleCrossRef" href="#bib0055"><span class="elsevierStyleSup">4</span></a> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">5 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">59 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Male \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Right thigh skin \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Angiomatoid nodular melanoma \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">S-100<span class="elsevierStyleSup">+</span>, HMB 45<span class="elsevierStyleSup">+</span>, MiTF-1<span class="elsevierStyleSup">+</span>Keratin AE1/AE3<span class="elsevierStyleSup">–</span>, CD31<span class="elsevierStyleSup">–</span> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Current case \t\t\t\t\t\t\n \t\t\t\t</td></tr></tbody></table> """ ] ] ] ] "descripcion" => array:1 [ "en" => "<p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">Cases of Angiomatoid Melanoma in the Literature.</p>" ] ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:7 [ 0 => array:3 [ "identificador" => "bib0040" "etiqueta" => "1" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Morphologic diversity in malignant melanomas" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "R.E. Nakhleh" 1 => "M.R. Wick" 2 => "A. Rocamora" 3 => "P.E. Swanson" 4 => "L.P. Dehner" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1093/ajcp/93.6.731" "Revista" => array:6 [ "tituloSerie" => "Am J Clin Pathol" "fecha" => "1990" "volumen" => "93" "paginaInicial" => "731" "paginaFinal" => "740" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/2346132" "web" => "Medline" ] ] ] ] ] ] ] ] 1 => array:3 [ "identificador" => "bib0045" "etiqueta" => "2" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Angiomatoid melanoma: A case of metastatic melanoma mimicking a vascular malignancy" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "M.J. Adler" 1 => "J. Beckstead" 2 => "C.R. White Jr." ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1097/00000372-199712000-00010" "Revista" => array:6 [ "tituloSerie" => "Am J Dermatopathol" "fecha" => "1997" "volumen" => "19" "paginaInicial" => "606" "paginaFinal" => "609" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9415619" "web" => "Medline" ] ] ] ] ] ] ] ] 2 => array:3 [ "identificador" => "bib0050" "etiqueta" => "3" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Angiomatoid melanoma: A novel pattern of differentiation in invasive periocular desmoplastic malignant melanoma" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "J. Baron" 1 => "F. Monzon" 2 => "N. Galaria" 3 => "G. Murphy" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1053/hupa.2000.21063" "Revista" => array:6 [ "tituloSerie" => "Hum Pathol" "fecha" => "2000" "volumen" => "31" "paginaInicial" => "1520" "paginaFinal" => "1522" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11150378" "web" => "Medline" ] ] ] ] ] ] ] ] 3 => array:3 [ "identificador" => "bib0055" "etiqueta" => "4" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Angiomatoid metastatic melanoma" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "B.G. Zelger" 1 => "B. Zelger" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1111/j.1524-4725.2004.30082.x" "Revista" => array:6 [ "tituloSerie" => "Dermatol Surg" "fecha" => "2004" "volumen" => "30" "paginaInicial" => "336" "paginaFinal" => "340" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/14871230" "web" => "Medline" ] ] ] ] ] ] ] ] 4 => array:3 [ "identificador" => "bib0060" "etiqueta" => "5" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Identification of cells lining pseudovascular spaces of benign pigmented nevi" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "R. Modlin" 1 => "C. Taylor" 2 => "B. Gottlieb" 3 => "T. Rea" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1097/00000372-198402000-00008" "Revista" => array:6 [ "tituloSerie" => "Am J Dermatopathol" "fecha" => "1984" "volumen" => "6" "paginaInicial" => "25" "paginaFinal" => "29" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/6367523" "web" => "Medline" ] ] ] ] ] ] ] ] 5 => array:3 [ "identificador" => "bib0065" "etiqueta" => "6" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Vascular channel formation by human melanoma cells in vivo and in vitro: Vasculogenic mimicry" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "A.J. Maniotis" 1 => "R. Folberg" 2 => "A. Hess" 3 => "E.A. Seftor" 4 => "L.M. Gardner" 5 => "J. Pe’er" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/S0002-9440(10)65173-5" "Revista" => array:6 [ "tituloSerie" => "Am J Pathol" "fecha" => "1999" "volumen" => "155" "paginaInicial" => "739" "paginaFinal" => "752" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10487832" "web" => "Medline" ] ] ] ] ] ] ] ] 6 => array:3 [ "identificador" => "bib0070" "etiqueta" => "7" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Pseudovascular adenoid squamous cell carcinoma of oral cavity: A mimicker of angiosarcoma" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "K. Vidyavathi" 1 => "C. Prasad" 2 => "H.M. Kumar" 3 => "R. Deo" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "J Oral Maxillofac Pathol." "fecha" => "2012" "volumen" => "2" "paginaInicial" => "288" "paginaFinal" => "290" ] ] ] ] ] ] ] ] ] ] ] "idiomaDefecto" => "en" "url" => "/15782190/0000010600000003/v3_202209240641/S1578219015000207/v3_202209240641/en/main.assets" "Apartado" => array:4 [ "identificador" => "34944" "tipo" => "SECCION" "en" => array:2 [ "titulo" => "e- Case Report" "idiomaDefecto" => true ] "idiomaDefecto" => "en" ] "PDF" => "https://static.elsevier.es/multimedia/15782190/0000010600000003/v3_202209240641/S1578219015000207/v3_202209240641/en/main.pdf?idApp=UINPBA000044&text.app=https://actasdermo.org/" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1578219015000207?idApp=UINPBA000044" ]
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2024 Agosto | 103 | 70 | 173 |
2024 Julio | 97 | 34 | 131 |
2024 Junio | 83 | 48 | 131 |
2024 Mayo | 82 | 37 | 119 |
2024 Abril | 82 | 37 | 119 |
2024 Marzo | 73 | 37 | 110 |
2024 Febrero | 73 | 35 | 108 |
2024 Enero | 64 | 41 | 105 |
2023 Diciembre | 63 | 19 | 82 |
2023 Noviembre | 76 | 25 | 101 |
2023 Octubre | 96 | 23 | 119 |
2023 Septiembre | 98 | 37 | 135 |
2023 Agosto | 63 | 27 | 90 |
2023 Julio | 82 | 37 | 119 |
2023 Junio | 60 | 34 | 94 |
2023 Mayo | 63 | 27 | 90 |
2023 Abril | 56 | 24 | 80 |
2023 Marzo | 68 | 28 | 96 |
2023 Febrero | 62 | 23 | 85 |
2023 Enero | 56 | 31 | 87 |
2022 Diciembre | 48 | 40 | 88 |
2022 Noviembre | 22 | 37 | 59 |
2022 Octubre | 21 | 17 | 38 |
2022 Septiembre | 42 | 33 | 75 |
2022 Agosto | 25 | 53 | 78 |
2022 Julio | 21 | 38 | 59 |
2022 Junio | 43 | 36 | 79 |
2022 Mayo | 49 | 34 | 83 |
2022 Abril | 50 | 41 | 91 |
2022 Marzo | 41 | 51 | 92 |
2022 Febrero | 62 | 29 | 91 |
2022 Enero | 72 | 29 | 101 |
2021 Diciembre | 49 | 37 | 86 |
2021 Noviembre | 52 | 42 | 94 |
2021 Octubre | 41 | 58 | 99 |
2021 Septiembre | 65 | 51 | 116 |
2021 Agosto | 35 | 28 | 63 |
2021 Julio | 35 | 35 | 70 |
2021 Junio | 37 | 47 | 84 |
2021 Mayo | 22 | 31 | 53 |
2021 Abril | 71 | 42 | 113 |
2021 Marzo | 48 | 16 | 64 |
2021 Febrero | 46 | 42 | 88 |
2021 Enero | 36 | 24 | 60 |
2020 Diciembre | 24 | 21 | 45 |
2020 Noviembre | 33 | 24 | 57 |
2020 Octubre | 23 | 20 | 43 |
2020 Septiembre | 22 | 15 | 37 |
2020 Agosto | 22 | 22 | 44 |
2020 Julio | 16 | 20 | 36 |
2020 Junio | 30 | 19 | 49 |
2020 Mayo | 30 | 27 | 57 |
2020 Abril | 30 | 25 | 55 |
2020 Marzo | 18 | 20 | 38 |
2020 Febrero | 3 | 3 | 6 |
2020 Enero | 0 | 1 | 1 |
2019 Diciembre | 4 | 3 | 7 |
2019 Noviembre | 0 | 3 | 3 |
2019 Octubre | 0 | 3 | 3 |
2019 Septiembre | 4 | 12 | 16 |
2019 Agosto | 0 | 4 | 4 |
2019 Julio | 0 | 5 | 5 |
2019 Junio | 2 | 3 | 5 |
2019 Mayo | 0 | 22 | 22 |
2019 Abril | 0 | 1 | 1 |
2019 Marzo | 2 | 7 | 9 |
2019 Febrero | 3 | 0 | 3 |
2019 Enero | 2 | 0 | 2 |
2018 Diciembre | 2 | 0 | 2 |
2018 Noviembre | 1 | 0 | 1 |
2018 Octubre | 5 | 0 | 5 |
2018 Septiembre | 3 | 0 | 3 |
2018 Agosto | 0 | 4 | 4 |
2018 Julio | 0 | 3 | 3 |
2018 Junio | 0 | 1 | 1 |
2018 Febrero | 25 | 3 | 28 |
2018 Enero | 39 | 4 | 43 |
2017 Diciembre | 55 | 8 | 63 |
2017 Noviembre | 33 | 19 | 52 |
2017 Octubre | 25 | 7 | 32 |
2017 Septiembre | 31 | 13 | 44 |
2017 Agosto | 27 | 7 | 34 |
2017 Julio | 26 | 7 | 33 |
2017 Junio | 36 | 28 | 64 |
2017 Mayo | 33 | 23 | 56 |
2017 Abril | 44 | 21 | 65 |
2017 Marzo | 23 | 37 | 60 |
2017 Febrero | 25 | 18 | 43 |
2017 Enero | 30 | 17 | 47 |
2016 Diciembre | 36 | 14 | 50 |
2016 Noviembre | 43 | 22 | 65 |
2016 Octubre | 26 | 28 | 54 |
2016 Septiembre | 0 | 8 | 8 |
2016 Agosto | 0 | 8 | 8 |
2016 Julio | 9 | 4 | 13 |
2016 Junio | 12 | 1 | 13 |
2016 Mayo | 5 | 1 | 6 |
2016 Abril | 12 | 9 | 21 |
2016 Marzo | 9 | 12 | 21 |
2016 Febrero | 10 | 16 | 26 |
2016 Enero | 15 | 11 | 26 |
2015 Diciembre | 18 | 2 | 20 |
2015 Noviembre | 5 | 2 | 7 |
2015 Octubre | 4 | 1 | 5 |
2015 Septiembre | 0 | 1 | 1 |
2015 Agosto | 0 | 4 | 4 |
2015 Julio | 5 | 2 | 7 |
2015 Junio | 2 | 1 | 3 |
2015 Mayo | 2 | 5 | 7 |
2015 Abril | 0 | 7 | 7 |