Case and Research Letters
Primitive Polypoid Granular-Cell Tumor
Tumor primitivo polipoide de células granulares
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López-Villaescusa, M. Rodríguez-Vázquez, M. García-Arpa, R. García-Angel" "autores" => array:4 [ 0 => array:4 [ "nombre" => "M.T." "apellidos" => "López-Villaescusa" "email" => array:1 [ 0 => "lopezvillaescusa@hotmail.com" ] "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">*</span>" "identificador" => "cor0005" ] ] ] 1 => array:3 [ "nombre" => "M." "apellidos" => "Rodríguez-Vázquez" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] ] ] 2 => array:3 [ "nombre" => "M." "apellidos" => "García-Arpa" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] ] ] 3 => array:3 [ "nombre" => "R." "apellidos" => "García-Angel" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">c</span>" "identificador" => "aff0015" ] ] ] ] "afiliaciones" => array:3 [ 0 => array:3 [ "entidad" => "Servicio de Dermatología, Complejo Hospitalario Universitario de Albacete, Albacete, Spain" "etiqueta" => "a" "identificador" => "aff0005" ] 1 => array:3 [ "entidad" => "Servicio de Dermatología, Hospital de Ciudad Real, Ciudad Real, Spain" "etiqueta" => "b" "identificador" => "aff0010" ] 2 => array:3 [ "entidad" => "Servicio de Anatomía Patológica, Complejo Hospitalario Universitario de Albacete, Albacete, Spain" "etiqueta" => "c" "identificador" => "aff0015" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "⁎" "correspondencia" => "Corresponding author." ] ] ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Tumor primitivo polipoide de células granulares" ] ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0010" "etiqueta" => "Figure 2" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr2.jpeg" "Alto" => 586 "Ancho" => 950 "Tamanyo" => 221167 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Cells with a polygonal morphology, abundant granular eosinophilic cytoplasm, and large vesicular nuclei. The cells are arranged in an interlinked fascicular pattern. Hematoxylin-eosin, original magnification ×40.</p>" ] ] ] "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">In contrast to conventional granular cell tumor (Abrikossoff tumor), primitive polypoid granular cell tumor was first identified by LeBoit et al.<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a> in 1991 and subsequently endorsed by Chaudhry and Calonje<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a> as a dermal tumor of granular cells of non-neural origin. The tumor has a polypoid morphology and presents numerous mitoses, cytologic atypia, and a primitive immunophenotype. We present a new case and review the characteristics of this rare and poorly known tumor.</p><p id="par0010" class="elsevierStylePara elsevierViewall">Our patient was a woman aged 44 years, with no past medical or family history of interest. She consulted for an asymptomatic lesion that had appeared 4 months earlier at the right nasolabial angle. Physical examination revealed a hard, polypoid lesion of 0.3<span class="elsevierStyleHsp" style=""></span>mm diameter, with a translucent surface. With a possible diagnosis of fibrous papule, milium cyst, or adnexal tumor (trichodiscoma), the lesion was excised. Histopathology revealed a circumscribed proliferation of cells in the superficial and mid dermis, surrounded by an epithelial collarette (<a class="elsevierStyleCrossRef" href="#fig0005">Fig. 1</a>). The cells, arranged in an interlinked fascicular pattern, had a poligonal morphology with abundant, granular eosinophilic cytoplasm and large vesicular nuclei (<a class="elsevierStyleCrossRef" href="#fig0010">Fig. 2</a>). Mitotic figures were present. No ulceration or necrosis was observed. Immunohistochemistry was positive for CD68 and negative for AE1-AE3, S-100, Melan A, CD34, desmin, actin, and smooth muscle. On the basis of these findings we made a diagnosis of primitive polypoid granular cell tumor.</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><elsevierMultimedia ident="fig0010"></elsevierMultimedia><p id="par0015" class="elsevierStylePara elsevierViewall">Granular cells can be found in a varied group of tumors and reflect the intracytoplasmic accumulation of lysosomes and other components of the Golgi aparatus. Traditional and conventional nomenclature makes reference to the cutaneous and mucosal granular cell tumor, known as Abrikossoff tumor, a benign neoplasm of neural origin derived from Schwann cells.<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a> However, other granular cell tumors of non-neural origin exist, including the congenital gingival granular cell tumor and the primitive polypoid granular cell tumor. In addition, numerous tumors can present granular cells, including myogenic tumors, melanocytic lesions, dermatofibroma, dermatofibrosarcoma protuberans, basal cell carcinoma, atypical fibroxanthoma, angiosarcoma, fibrous papule, ameloblastoma, and adnexal tumors with eccrine or apocrine differentiation.<a class="elsevierStyleCrossRef" href="#bib0020"><span class="elsevierStyleSup">4</span></a></p><p id="par0020" class="elsevierStylePara elsevierViewall">Primitive polypoid granular cell tumor is a rare neoplasm or uncertain origin that affects middle-aged adults. It usually arises on the trunk or limbs as a polypoid or elevated lesion with a smooth surface; its size can be variable. The distinctive characteristic that differentiates it from conventional granular cell tumor is its histopathology, which shows a tumor in the mid dermis that is clearly surrounded by an epidermal collarette; the tumor is formed of large polygonal, round or spindle-shaped cells with marked nuclear pleomorphism, an elongated nucleus, abundant eosinophilic cytoplasm containing fine granules, and mitotic activity of around 1 to 3 mitoses per mm,<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a> usually with no atypia and minimal or absent epidermal hyperplasia. These histopathology findings satisfy the criteria proposed by Enzinger and Weiss for the classification of malignant or atypical granular cell tumor, but the tumors can be differentiated by immunohistochemistry, as primitive polypoid granular cell tumor is usually negative for S-100 and positive for CD68 and neuron-specific enolase.<a class="elsevierStyleCrossRef" href="#bib0025"><span class="elsevierStyleSup">5</span></a></p><p id="par0025" class="elsevierStylePara elsevierViewall">Despite the histological characteristics, this is a tumor of low–grade malignancy. In the series reported there is only 1 case of metastasis, which arose in the cheek 25 months after excision of the lesion and did not present an epidermal collarette on histology.<a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">6</span></a></p><p id="par0030" class="elsevierStylePara elsevierViewall">We have presented a new case of primitive polypoid granular cell tumor, a variant that is not clearly distinguished from the conventional tumor. Its atypical histological characteristics allow it to be classified as a new entity and distinguished from granular cell tumor of neural origin.</p></span>" "pdfFichero" => "main.pdf" "tienePdf" => true "NotaPie" => array:1 [ 0 => array:2 [ "etiqueta" => "☆" "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Please cite this article as: López-Villaescusa M, Rodríguez-Vázquez M, García-Arpa M, García-Angel R. Tumor primitivo polipoide de células granulares. Actas Dermosifiliogr. 2014;105:878–879.</p>" ] ] "multimedia" => array:2 [ 0 => array:7 [ "identificador" => "fig0005" "etiqueta" => "Figure 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 1087 "Ancho" => 950 "Tamanyo" => 317986 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Tumor in the superficial and mid dermis, surrounded by an epithelial collarette. Hematoxylin-eosin, original magnification ×10.</p>" ] ] 1 => array:7 [ "identificador" => "fig0010" "etiqueta" => "Figure 2" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr2.jpeg" "Alto" => 586 "Ancho" => 950 "Tamanyo" => 221167 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Cells with a polygonal morphology, abundant granular eosinophilic cytoplasm, and large vesicular nuclei. The cells are arranged in an interlinked fascicular pattern. Hematoxylin-eosin, original magnification ×40.</p>" ] ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:6 [ 0 => array:3 [ "identificador" => "bib0005" "etiqueta" => "1" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Primitive polypoid granular-cell tumor and other cutaneous granular-cell neoplasms of apparent nonneural origin" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "E. Philip" 1 => "M.D. LeBoit" 2 => "J. Ronald" 3 => "M.D. Barr" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Am J Surg Pathol" "fecha" => "1991" "volumen" => "15" "paginaInicial" => "48" "paginaFinal" => "58" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/1985501" "web" => "Medline" ] ] ] ] ] ] ] ] 1 => array:3 [ "identificador" => "bib0010" "etiqueta" => "2" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Dermal non-neural granular cell tumor (so-called primitive polypoid granular cell tumor): A distinctive further delineated in a clinicopathological study of 11 cases" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "I.H. Chaudhry" 1 => "E. Caljonje" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1111/j.1365-2559.2005.02192.x" "Revista" => array:6 [ "tituloSerie" => "Histopathology" "fecha" => "2005" "volumen" => "47" "paginaInicial" => "179" "paginaFinal" => "185" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16045779" "web" => "Medline" ] ] ] ] ] ] ] ] 2 => array:3 [ "identificador" => "bib0015" "etiqueta" => "3" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Tumor de células granulares cutáneo: análisis clínico-patológico de treinta y cuatro casos" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "A. Torrijos-Aguilar" 1 => "V. Alegre-de Miquel" 2 => "G. Pitarch-Bort" 3 => "P. Mercader-García" 4 => "J.M. Fortea-Baixauli" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Actas Dermosifiliogr" "fecha" => "2009" "volumen" => "100" "paginaInicial" => "126" "paginaFinal" => "132" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19445877" "web" => "Medline" ] ] ] ] ] ] ] ] 3 => array:3 [ "identificador" => "bib0020" "etiqueta" => "4" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Cutaneous granular cell tumor. Report of three cases and review of the literature" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "B. Di Martino" 1 => "A. Soskin" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Our Dermatol Online" "fecha" => "2012" "volumen" => "3" "paginaInicial" => "46" "paginaFinal" => "51" ] ] ] ] ] ] 4 => array:3 [ "identificador" => "bib0025" "etiqueta" => "5" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Value of S-100 protein in the diagnosis of soft tissue tumors with particular reference to benign and malignant Schwann cell tumors" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "S.W. Weiss" 1 => "J.M. Langloss" 2 => "F.M. 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| año/Mes | Html | Total | |
|---|---|---|---|
| 2024 Noviembre | 8 | 9 | 17 |
| 2024 Octubre | 90 | 43 | 133 |
| 2024 Septiembre | 97 | 37 | 134 |
| 2024 Agosto | 116 | 58 | 174 |
| 2024 Julio | 94 | 39 | 133 |
| 2024 Junio | 117 | 34 | 151 |
| 2024 Mayo | 71 | 36 | 107 |
| 2024 Abril | 83 | 26 | 109 |
| 2024 Marzo | 84 | 28 | 112 |
| 2024 Febrero | 70 | 31 | 101 |
| 2024 Enero | 74 | 31 | 105 |
| 2023 Diciembre | 69 | 14 | 83 |
| 2023 Noviembre | 84 | 23 | 107 |
| 2023 Octubre | 101 | 23 | 124 |
| 2023 Septiembre | 79 | 24 | 103 |
| 2023 Agosto | 69 | 12 | 81 |
| 2023 Julio | 101 | 26 | 127 |
| 2023 Junio | 71 | 25 | 96 |
| 2023 Mayo | 71 | 21 | 92 |
| 2023 Abril | 57 | 14 | 71 |
| 2023 Marzo | 70 | 18 | 88 |
| 2023 Febrero | 35 | 19 | 54 |
| 2023 Enero | 46 | 32 | 78 |
| 2022 Diciembre | 68 | 47 | 115 |
| 2022 Noviembre | 47 | 19 | 66 |
| 2022 Octubre | 28 | 14 | 42 |
| 2022 Septiembre | 33 | 27 | 60 |
| 2022 Agosto | 33 | 35 | 68 |
| 2022 Julio | 28 | 36 | 64 |
| 2022 Junio | 42 | 25 | 67 |
| 2022 Mayo | 51 | 24 | 75 |
| 2022 Abril | 56 | 32 | 88 |
| 2022 Marzo | 50 | 43 | 93 |
| 2022 Febrero | 35 | 25 | 60 |
| 2022 Enero | 59 | 36 | 95 |
| 2021 Diciembre | 47 | 28 | 75 |
| 2021 Noviembre | 58 | 44 | 102 |
| 2021 Octubre | 57 | 57 | 114 |
| 2021 Septiembre | 44 | 33 | 77 |
| 2021 Agosto | 54 | 32 | 86 |
| 2021 Julio | 46 | 31 | 77 |
| 2021 Junio | 48 | 32 | 80 |
| 2021 Mayo | 62 | 18 | 80 |
| 2021 Abril | 118 | 52 | 170 |
| 2021 Marzo | 60 | 18 | 78 |
| 2021 Febrero | 58 | 20 | 78 |
| 2021 Enero | 35 | 13 | 48 |
| 2020 Diciembre | 42 | 19 | 61 |
| 2020 Noviembre | 20 | 19 | 39 |
| 2020 Octubre | 27 | 2 | 29 |
| 2020 Septiembre | 21 | 10 | 31 |
| 2020 Agosto | 17 | 10 | 27 |
| 2020 Julio | 23 | 8 | 31 |
| 2020 Junio | 42 | 17 | 59 |
| 2020 Mayo | 23 | 18 | 41 |
| 2020 Abril | 20 | 6 | 26 |
| 2020 Marzo | 35 | 12 | 47 |
| 2020 Febrero | 1 | 2 | 3 |
| 2020 Enero | 0 | 4 | 4 |
| 2019 Diciembre | 4 | 2 | 6 |
| 2019 Noviembre | 0 | 1 | 1 |
| 2019 Septiembre | 4 | 1 | 5 |
| 2019 Julio | 0 | 1 | 1 |
| 2019 Junio | 2 | 3 | 5 |
| 2019 Mayo | 0 | 43 | 43 |
| 2019 Abril | 0 | 21 | 21 |
| 2019 Marzo | 2 | 6 | 8 |
| 2019 Febrero | 1 | 0 | 1 |
| 2019 Enero | 2 | 0 | 2 |
| 2018 Diciembre | 2 | 0 | 2 |
| 2018 Noviembre | 9 | 0 | 9 |
| 2018 Octubre | 26 | 0 | 26 |
| 2018 Septiembre | 3 | 1 | 4 |
| 2018 Agosto | 0 | 3 | 3 |
| 2018 Julio | 0 | 8 | 8 |
| 2018 Junio | 0 | 1 | 1 |
| 2018 Abril | 0 | 8 | 8 |
| 2018 Marzo | 9 | 3 | 12 |
| 2018 Febrero | 70 | 4 | 74 |
| 2018 Enero | 49 | 4 | 53 |
| 2017 Diciembre | 75 | 8 | 83 |
| 2017 Noviembre | 37 | 16 | 53 |
| 2017 Octubre | 27 | 6 | 33 |
| 2017 Septiembre | 43 | 12 | 55 |
| 2017 Agosto | 43 | 12 | 55 |
| 2017 Julio | 37 | 7 | 44 |
| 2017 Junio | 43 | 11 | 54 |
| 2017 Mayo | 25 | 8 | 33 |
| 2017 Abril | 27 | 11 | 38 |
| 2017 Marzo | 12 | 9 | 21 |
| 2017 Febrero | 16 | 17 | 33 |
| 2017 Enero | 17 | 13 | 30 |
| 2016 Diciembre | 34 | 16 | 50 |
| 2016 Noviembre | 39 | 19 | 58 |
| 2016 Octubre | 35 | 24 | 59 |
| 2016 Septiembre | 0 | 6 | 6 |
| 2016 Agosto | 0 | 2 | 2 |
| 2016 Julio | 5 | 2 | 7 |
| 2016 Junio | 18 | 16 | 34 |
| 2016 Mayo | 10 | 9 | 19 |
| 2016 Abril | 11 | 13 | 24 |
| 2016 Marzo | 8 | 11 | 19 |
| 2016 Febrero | 11 | 3 | 14 |
| 2016 Enero | 19 | 1 | 20 |
| 2015 Diciembre | 12 | 14 | 26 |
| 2015 Noviembre | 18 | 17 | 35 |
| 2015 Octubre | 14 | 4 | 18 |
| 2015 Septiembre | 11 | 1 | 12 |
| 2015 Agosto | 7 | 2 | 9 |
| 2015 Julio | 22 | 5 | 27 |
| 2015 Junio | 41 | 2 | 43 |
| 2015 Mayo | 23 | 3 | 26 |
| 2015 Abril | 15 | 8 | 23 |
| 2015 Marzo | 20 | 9 | 29 |
| 2015 Febrero | 14 | 1 | 15 |
| 2015 Enero | 9 | 2 | 11 |
| 2014 Diciembre | 8 | 3 | 11 |
| 2014 Noviembre | 3 | 0 | 3 |
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