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Her personal history was remarkable for autoimmune hypothyroidism &#40;Hashimoto thyroiditis&#41; that first appeared 5 years previously and for which she was receiving hormone replacement therapy &#40;levothyroxine 75<span class="elsevierStyleHsp" style=""></span>&#956;g&#47;d&#41;&#46; She also had a 1-year history of autoimmune hepatitis&#44; which was treated with prednisone &#40;7&#46;5<span class="elsevierStyleHsp" style=""></span>mg&#47;d po&#41;&#44; and hypertension&#44; which was treated with enalapril &#40;20<span class="elsevierStyleHsp" style=""></span>mg&#47;d po&#41;&#46; She attended our clinic with bilateral eyelid swelling that had begun 24<span class="elsevierStyleHsp" style=""></span>hours earlier&#46; The patient had not ingested new drugs&#44; experienced injury&#44; received insect bites or stings&#44; or applied cosmetic products to the area&#46; Examination revealed soft bilateral edema that was more pronounced on the right side with discrete erythema and no crepitus&#44; vesicles&#44; or desquamation &#40;<a class="elsevierStyleCrossRefs" href="#fig0005">Figs&#46; 1 and 2</a>&#41;&#46; Her visual acuity and eye movement were unaltered&#44; and she had no skin lesions at other sites&#46; The results of a full laboratory workup were normal&#44; although thyroid-stimulating hormone &#40;TSH&#41; was 50&#46;3<span class="elsevierStyleHsp" style=""></span>mIU&#47;L and free thyroxine was diminished &#40;0&#46;5<span class="elsevierStyleHsp" style=""></span>ng&#47;dL&#41;&#46; The dose of levothyroxine was increased considerably &#40;500<span class="elsevierStyleHsp" style=""></span>&#956;g&#47;d&#41;&#44; as was that of oral prednisone &#40;15<span class="elsevierStyleHsp" style=""></span>mg&#47;d&#41;&#44; to reduce inflammation&#46; Seven days after the first visit&#44; her TSH level had fallen to 35<span class="elsevierStyleHsp" style=""></span>mIU&#47;L&#44; thyroid hormone levels had returned to normal&#44; and the swelling had improved considerably&#46; A week later&#44; the skin complaint was in total remission &#40;<a class="elsevierStyleCrossRef" href="#fig0015">Fig&#46; 3</a>&#41; and the TSH concentration had fallen to 20<span class="elsevierStyleHsp" style=""></span>mIU&#47;L&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><elsevierMultimedia ident="fig0010"></elsevierMultimedia><elsevierMultimedia ident="fig0015"></elsevierMultimedia><p id="par0015" class="elsevierStylePara elsevierViewall">The characteristics of the lesion and the clinical course confirmed a diagnosis of bilateral eyelid swelling associated with acute hypothyroidism&#46;</p><p id="par0020" class="elsevierStylePara elsevierViewall">The differential diagnosis of eyelid swelling should include various clinical entities &#40;<a class="elsevierStyleCrossRef" href="#fig0020">Fig&#46; 4</a>&#41;&#46; A careful evaluation should be made of the intensity&#44; location &#40;one or both eyelids&#41;&#44; and coloring of the swelling&#46; The initial examination first makes it possible to rule out swelling caused by trapped air&#44; with its characteristic crunching snow sensation&#44; and blood pooling in the case of hematoma&#46; Finally&#44; it is necessary to define whether the swelling is inflammatory or noninflammatory and analyze the possible causes&#46;</p><elsevierMultimedia ident="fig0020"></elsevierMultimedia><p id="par0025" class="elsevierStylePara elsevierViewall">Eyelid swelling associated with hypothyroidism is uncommon and can occasionally mimic other conditions such as angioedema&#44; bites and stings&#44; and contact dermatitis&#46;<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a> In the case we describe&#44; the absence of induration&#44; vesicles&#44; and pruritus make a diagnosis of eczema or angioedema unlikely&#59; in addition&#44; the patient&#39;s clinical condition improved considerably when the acute hypothyroidism resolved&#46; The causes of swelling are not well known&#44; although mucopolysaccharide deposits play a role&#46; Case reports show that eyelid swelling is a clinical sign of severe acute hypothyroidism&#46; It is sometimes more subtle&#44; is associated with thinning of the eyebrows&#44;<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a> and&#44; in some cases&#44; can manifest as palpebral redundancy resulting from laxity of the eyelid&#46;<a class="elsevierStyleCrossRef" href="#bib0020"><span class="elsevierStyleSup">4</span></a> The swelling resolves gradually with treatment of hypothyroidism&#46;<a class="elsevierStyleCrossRefs" href="#bib0020"><span class="elsevierStyleSup">4&#44;5</span></a></p><p id="par0030" class="elsevierStylePara elsevierViewall">Eyelid swelling is not the only dermatologic manifestation associated with hypothyroidism&#44; and other more common presentations sometimes go unnoticed&#46; In more than 80&#37; of cases the epidermis is thin&#44; dry&#44; rough&#44; hyperkeratotic&#44; and covered with fine superficial scales&#46;<a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">6</span></a> The hair is opaque&#44; rough&#44; and brittle&#44; partly owing to reduced secretion of sebum&#46; Alopecia has been reported in up to 50&#37; of patients and can be diffuse or partial&#59; the nails are thin and fragile with striations and horizontal and longitudinal ridges&#46;<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">7</span></a></p><p id="par0035" class="elsevierStylePara elsevierViewall">Finally&#44; in the case of sudden-onset asymptomatic bilateral soft swelling in which dermatitis and angioedema can be ruled out&#44; systemic causes such as hypothyroidism should be suspected&#46; Therefore&#44; eyelid swelling can be a sign of numerous local and systemic diseases and requires a meticulous clinical workup in order to determine the cause and enable appropriate treatment to be started&#46;</p></span>"
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                      "titulo" => "Palpebral redundancy from hypothyroidism"
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                        "tituloSerie" => "Plast Reconstr Surg"
                        "fecha" => "1980"
                        "volumen" => "65"
                        "paginaInicial" => "1"
                        "paginaFinal" => "3"
                        "link" => array:1 [
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                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Pitting oedema in hypothyroidism"
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                        0 => array:2 [
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                            3 => "S&#46; Taneja"
                            4 => "R&#46; Raina"
                            5 => "S&#46; Thakur"
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                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/14710975"
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                        "tituloSerie" => "Med Clin North Am"
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                        "link" => array:1 [
                          0 => array:2 [
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                ]
              ]
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                0 => array:2 [
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                      "titulo" => "Atypical presentations of primary hypothyroidism in primary care"
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                        0 => array:2 [
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                          "autores" => array:6 [
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                            3 => "I&#46;M&#46; Nieto Clemente"
                            4 => "M&#46;F&#46; Mar&#237;n-Bl&#225;zquez"
                            5 => "V&#46; Salcedo Joven"
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                    ]
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                      "Revista" => array:6 [
                        "tituloSerie" => "Aten Primaria"
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                        "paginaFinal" => "619"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/1511111"
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                ]
              ]
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              "identificador" => "bib0030"
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                0 => array:2 [
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                      "titulo" => "Cutaneous manifestations of thyroid disease"
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Case and Research letter
Bilateral Eyelid Swelling Associated With Acute Hypothyroidism
Edema palpebral bilateral asociado a crisis hipotiroidea
M. Salazar-Nievasa, S. Arias-Santiagob,
Autor para correspondencia
salvadorarias@hotmail.es

Corresponding author.
a Servicio de Dermatología, Hospital Universitario San Cecilio, Granada, Spain
b Servicio de Dermatología, Hospital Virgen de las Nieves, Granada, Spain
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        "titulo" => "Edema palpebral bilateral asociado a crisis hipotiroidea"
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          "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Eyelid swelling 24<span class="elsevierStyleHsp" style=""></span>hours after onset&#46; The lesion was neither warm to the touch nor painful and was more pronounced on the right&#46;</p>"
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    "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">The eyelid is subject to considerable deformity owing to the particular laxity of the subcutaneous cellular tissue&#44; which is caused by infiltration of the interstitial spaces&#46; The degree of swelling can range from simple tumefaction of the ciliary margin to a considerable increase in periocular tissue volume&#44; which in some cases can lead to narrowing&#44; or even closure&#44; of the palpebral fissure&#46; Differential diagnosis of eyelid swelling is complex&#46; It requires a meticulous physical examination and inclusion of both inflammatory and noninflammatory causes&#46; The main noninflammatory cause is acute hypothyroidism&#44; as in the present case&#46;<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a></p><p id="par0010" class="elsevierStylePara elsevierViewall">We describe the case of a 52-year-old woman who presented with a 1-week history of sudden-onset bilateral eyelid swelling that was neither painful nor pruriginous&#46; Her personal history was remarkable for autoimmune hypothyroidism &#40;Hashimoto thyroiditis&#41; that first appeared 5 years previously and for which she was receiving hormone replacement therapy &#40;levothyroxine 75<span class="elsevierStyleHsp" style=""></span>&#956;g&#47;d&#41;&#46; She also had a 1-year history of autoimmune hepatitis&#44; which was treated with prednisone &#40;7&#46;5<span class="elsevierStyleHsp" style=""></span>mg&#47;d po&#41;&#44; and hypertension&#44; which was treated with enalapril &#40;20<span class="elsevierStyleHsp" style=""></span>mg&#47;d po&#41;&#46; She attended our clinic with bilateral eyelid swelling that had begun 24<span class="elsevierStyleHsp" style=""></span>hours earlier&#46; The patient had not ingested new drugs&#44; experienced injury&#44; received insect bites or stings&#44; or applied cosmetic products to the area&#46; Examination revealed soft bilateral edema that was more pronounced on the right side with discrete erythema and no crepitus&#44; vesicles&#44; or desquamation &#40;<a class="elsevierStyleCrossRefs" href="#fig0005">Figs&#46; 1 and 2</a>&#41;&#46; Her visual acuity and eye movement were unaltered&#44; and she had no skin lesions at other sites&#46; The results of a full laboratory workup were normal&#44; although thyroid-stimulating hormone &#40;TSH&#41; was 50&#46;3<span class="elsevierStyleHsp" style=""></span>mIU&#47;L and free thyroxine was diminished &#40;0&#46;5<span class="elsevierStyleHsp" style=""></span>ng&#47;dL&#41;&#46; The dose of levothyroxine was increased considerably &#40;500<span class="elsevierStyleHsp" style=""></span>&#956;g&#47;d&#41;&#44; as was that of oral prednisone &#40;15<span class="elsevierStyleHsp" style=""></span>mg&#47;d&#41;&#44; to reduce inflammation&#46; Seven days after the first visit&#44; her TSH level had fallen to 35<span class="elsevierStyleHsp" style=""></span>mIU&#47;L&#44; thyroid hormone levels had returned to normal&#44; and the swelling had improved considerably&#46; A week later&#44; the skin complaint was in total remission &#40;<a class="elsevierStyleCrossRef" href="#fig0015">Fig&#46; 3</a>&#41; and the TSH concentration had fallen to 20<span class="elsevierStyleHsp" style=""></span>mIU&#47;L&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><elsevierMultimedia ident="fig0010"></elsevierMultimedia><elsevierMultimedia ident="fig0015"></elsevierMultimedia><p id="par0015" class="elsevierStylePara elsevierViewall">The characteristics of the lesion and the clinical course confirmed a diagnosis of bilateral eyelid swelling associated with acute hypothyroidism&#46;</p><p id="par0020" class="elsevierStylePara elsevierViewall">The differential diagnosis of eyelid swelling should include various clinical entities &#40;<a class="elsevierStyleCrossRef" href="#fig0020">Fig&#46; 4</a>&#41;&#46; A careful evaluation should be made of the intensity&#44; location &#40;one or both eyelids&#41;&#44; and coloring of the swelling&#46; The initial examination first makes it possible to rule out swelling caused by trapped air&#44; with its characteristic crunching snow sensation&#44; and blood pooling in the case of hematoma&#46; Finally&#44; it is necessary to define whether the swelling is inflammatory or noninflammatory and analyze the possible causes&#46;</p><elsevierMultimedia ident="fig0020"></elsevierMultimedia><p id="par0025" class="elsevierStylePara elsevierViewall">Eyelid swelling associated with hypothyroidism is uncommon and can occasionally mimic other conditions such as angioedema&#44; bites and stings&#44; and contact dermatitis&#46;<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a> In the case we describe&#44; the absence of induration&#44; vesicles&#44; and pruritus make a diagnosis of eczema or angioedema unlikely&#59; in addition&#44; the patient&#39;s clinical condition improved considerably when the acute hypothyroidism resolved&#46; The causes of swelling are not well known&#44; although mucopolysaccharide deposits play a role&#46; Case reports show that eyelid swelling is a clinical sign of severe acute hypothyroidism&#46; It is sometimes more subtle&#44; is associated with thinning of the eyebrows&#44;<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a> and&#44; in some cases&#44; can manifest as palpebral redundancy resulting from laxity of the eyelid&#46;<a class="elsevierStyleCrossRef" href="#bib0020"><span class="elsevierStyleSup">4</span></a> The swelling resolves gradually with treatment of hypothyroidism&#46;<a class="elsevierStyleCrossRefs" href="#bib0020"><span class="elsevierStyleSup">4&#44;5</span></a></p><p id="par0030" class="elsevierStylePara elsevierViewall">Eyelid swelling is not the only dermatologic manifestation associated with hypothyroidism&#44; and other more common presentations sometimes go unnoticed&#46; In more than 80&#37; of cases the epidermis is thin&#44; dry&#44; rough&#44; hyperkeratotic&#44; and covered with fine superficial scales&#46;<a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">6</span></a> The hair is opaque&#44; rough&#44; and brittle&#44; partly owing to reduced secretion of sebum&#46; Alopecia has been reported in up to 50&#37; of patients and can be diffuse or partial&#59; the nails are thin and fragile with striations and horizontal and longitudinal ridges&#46;<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">7</span></a></p><p id="par0035" class="elsevierStylePara elsevierViewall">Finally&#44; in the case of sudden-onset asymptomatic bilateral soft swelling in which dermatitis and angioedema can be ruled out&#44; systemic causes such as hypothyroidism should be suspected&#46; Therefore&#44; eyelid swelling can be a sign of numerous local and systemic diseases and requires a meticulous clinical workup in order to determine the cause and enable appropriate treatment to be started&#46;</p></span>"
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        "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Please cite this article as&#58; Salazar-Nievas M&#44; Arias-Santiago S&#46; Edema palpebral bilateral asociado a crisis hipotiroidea&#46; Actas Dermosifiliogr&#46; 2014&#59;105&#58;427&#8211;429&#46;</p>"
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              "identificador" => "bib0005"
              "etiqueta" => "1"
              "referencia" => array:1 [
                0 => array:1 [
                  "referenciaCompleta" => "Alonso Caviedes S&#44; Collado Hornillos JA&#44; G&#243;mez Dacasa A&#46; Oftalmolog&#237;a II&#46; Santander&#58; Ed&#46; Universidad de Cantabria&#59; 1991&#46; p&#46; 61&#46;"
                ]
              ]
            ]
            1 => array:3 [
              "identificador" => "bib0010"
              "etiqueta" => "2"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Palpebral redundancy from hypothyroidism"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "J&#46; Wortsman"
                            1 => "P&#46; Wavak"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Plast Reconstr Surg"
                        "fecha" => "1980"
                        "volumen" => "65"
                        "paginaInicial" => "1"
                        "paginaFinal" => "3"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7350570"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            2 => array:3 [
              "identificador" => "bib0015"
              "etiqueta" => "3"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Pitting oedema in hypothyroidism"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "S&#46;K&#46; Mahajan"
                            1 => "P&#46;C&#46; Machhan"
                            2 => "B&#46;R&#46; Sood"
                            3 => "S&#46; Taneja"
                            4 => "R&#46; Raina"
                            5 => "S&#46; Thakur"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "J Assoc Physicians India"
                        "fecha" => "2003"
                        "volumen" => "51"
                        "paginaInicial" => "885"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/14710975"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            3 => array:3 [
              "identificador" => "bib0020"
              "etiqueta" => "4"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Hypothyroidism&#58; Etiology&#44; diagnosis&#44; and management"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "J&#46;P&#46; Almandoz"
                            1 => "H&#46; Gharib"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.mcna.2012.01.005"
                      "Revista" => array:6 [
                        "tituloSerie" => "Med Clin North Am"
                        "fecha" => "2012"
                        "volumen" => "96"
                        "paginaInicial" => "203"
                        "paginaFinal" => "221"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/22443971"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
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              "identificador" => "bib0025"
              "etiqueta" => "5"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Atypical presentations of primary hypothyroidism in primary care"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "J&#46;M&#46; Rubio Ruiz"
                            1 => "M&#46;A&#46; P&#233;rez Mena"
                            2 => "F&#46; Cirujano Pita"
                            3 => "I&#46;M&#46; Nieto Clemente"
                            4 => "M&#46;F&#46; Mar&#237;n-Bl&#225;zquez"
                            5 => "V&#46; Salcedo Joven"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Aten Primaria"
                        "fecha" => "1992"
                        "volumen" => "10"
                        "paginaInicial" => "617"
                        "paginaFinal" => "619"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/1511111"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            5 => array:3 [
              "identificador" => "bib0030"
              "etiqueta" => "6"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Cutaneous manifestations of thyroid disease"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "D&#46;N&#46; Doshi"
                            1 => "M&#46;L&#46; Blyumin"
                            2 => "A&#46;B&#46; Kimball"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.clindermatol.2007.10.020"
                      "Revista" => array:6 [
                        "tituloSerie" => "Clin Dermatol"
                        "fecha" => "2008"
                        "volumen" => "26"
                        "paginaInicial" => "283"
                        "paginaFinal" => "287"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18640525"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            6 => array:3 [
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              "etiqueta" => "7"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Cutaneous manifestations of endocrine disorders&#58; A guide for dermatologists"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "S&#46;A&#46; Jabbour"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Am J Clin Dermatol"
                        "fecha" => "2003"
                        "volumen" => "4"
                        "paginaInicial" => "315"
                        "paginaFinal" => "331"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12688837"
                            "web" => "Medline"
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                      ]
                    ]
                  ]
                ]
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            ]
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2014 Diciembre 45 12 57
2014 Noviembre 49 10 59
2014 Octubre 31 12 43
2014 Septiembre 31 9 40
2014 Agosto 30 17 47
2014 Julio 13 7 20
2014 Junio 38 10 48
2014 Mayo 24 6 30
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¿Es usted profesional sanitario apto para prescribir o dispensar medicamentos?

Are you a health professional able to prescribe or dispense drugs?