array:24 [
  "pii" => "S1578219014000274"
  "issn" => "15782190"
  "doi" => "10.1016/j.adengl.2013.02.015"
  "estado" => "S300"
  "fechaPublicacion" => "2014-03-01"
  "aid" => "808"
  "copyright" => "Elsevier España, S.L. and AEDV"
  "copyrightAnyo" => "2012"
  "documento" => "simple-article"
  "crossmark" => 0
  "subdocumento" => "cor"
  "cita" => "Actas Dermosifiliogr. 2014;105:204-6"
  "abierto" => array:3 [
    "ES" => true
    "ES2" => true
    "LATM" => true
  ]
  "gratuito" => true
  "lecturas" => array:2 [
    "total" => 2965
    "formatos" => array:3 [
      "EPUB" => 42
      "HTML" => 2515
      "PDF" => 408
    ]
  ]
  "Traduccion" => array:1 [
    "es" => array:19 [
      "pii" => "S0001731013000616"
      "issn" => "00017310"
      "doi" => "10.1016/j.ad.2013.02.002"
      "estado" => "S300"
      "fechaPublicacion" => "2014-03-01"
      "aid" => "808"
      "copyright" => "Elsevier España, S.L. y AEDV"
      "documento" => "simple-article"
      "crossmark" => 0
      "subdocumento" => "cor"
      "cita" => "Actas Dermosifiliogr. 2014;105:204-6"
      "abierto" => array:3 [
        "ES" => true
        "ES2" => true
        "LATM" => true
      ]
      "gratuito" => true
      "lecturas" => array:2 [
        "total" => 3182
        "formatos" => array:3 [
          "EPUB" => 2
          "HTML" => 2365
          "PDF" => 815
        ]
      ]
      "es" => array:11 [
        "idiomaDefecto" => true
        "cabecera" => "<span class="elsevierStyleTextfn">Carta cient&#237;fico-cl&#237;nica</span>"
        "titulo" => "Esporotricosis diseminada con afecci&#243;n cut&#225;nea y testicular"
        "tienePdf" => "es"
        "tieneTextoCompleto" => "es"
        "paginas" => array:1 [
          0 => array:2 [
            "paginaInicial" => "204"
            "paginaFinal" => "206"
          ]
        ]
        "titulosAlternativos" => array:1 [
          "en" => array:1 [
            "titulo" => "Disseminated Sporotrichosis With Cutaneous and Testicular Involvement"
          ]
        ]
        "contieneTextoCompleto" => array:1 [
          "es" => true
        ]
        "contienePdf" => array:1 [
          "es" => true
        ]
        "resumenGrafico" => array:2 [
          "original" => 0
          "multimedia" => array:7 [
            "identificador" => "fig0005"
            "etiqueta" => "Figura 1"
            "tipo" => "MULTIMEDIAFIGURA"
            "mostrarFloat" => true
            "mostrarDisplay" => false
            "figura" => array:1 [
              0 => array:4 [
                "imagen" => "gr1.jpeg"
                "Alto" => 1064
                "Ancho" => 1501
                "Tamanyo" => 214964
              ]
            ]
            "descripcion" => array:1 [
              "es" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">A&#46; P&#250;stulas y p&#225;pulas necr&#243;ticas en el tronco y las extremidades inferiores&#46; B&#46; &#218;lceras y necrosis extensa en la cabeza&#46; C y D&#46; Grandes &#250;lceras en el antebrazo izquierdo con exposici&#243;n de tendones y m&#250;sculo&#46;</p>"
            ]
          ]
        ]
        "autores" => array:1 [
          0 => array:2 [
            "autoresLista" => "C&#46;J&#46; Espinoza-Hern&#225;ndez, A&#46; Jes&#250;s-Silva, S&#46; Toussaint-Caire, R&#46; Arenas"
            "autores" => array:4 [
              0 => array:2 [
                "nombre" => "C&#46;J&#46;"
                "apellidos" => "Espinoza-Hern&#225;ndez"
              ]
              1 => array:2 [
                "nombre" => "A&#46;"
                "apellidos" => "Jes&#250;s-Silva"
              ]
              2 => array:2 [
                "nombre" => "S&#46;"
                "apellidos" => "Toussaint-Caire"
              ]
              3 => array:2 [
                "nombre" => "R&#46;"
                "apellidos" => "Arenas"
              ]
            ]
          ]
        ]
      ]
      "idiomaDefecto" => "es"
      "Traduccion" => array:1 [
        "en" => array:9 [
          "pii" => "S1578219014000274"
          "doi" => "10.1016/j.adengl.2013.02.015"
          "estado" => "S300"
          "subdocumento" => ""
          "abierto" => array:3 [
            "ES" => true
            "ES2" => true
            "LATM" => true
          ]
          "gratuito" => true
          "lecturas" => array:1 [
            "total" => 0
          ]
          "idiomaDefecto" => "en"
          "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1578219014000274?idApp=UINPBA000044"
        ]
      ]
      "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0001731013000616?idApp=UINPBA000044"
      "url" => "/00017310/0000010500000002/v1_201403120205/S0001731013000616/v1_201403120205/es/main.assets"
    ]
  ]
  "itemSiguiente" => array:19 [
    "pii" => "S1578219014000286"
    "issn" => "15782190"
    "doi" => "10.1016/j.adengl.2013.02.016"
    "estado" => "S300"
    "fechaPublicacion" => "2014-03-01"
    "aid" => "817"
    "copyright" => "Elsevier Espa&#241;a&#44; S&#46;L&#46; and AEDV"
    "documento" => "simple-article"
    "crossmark" => 0
    "subdocumento" => "cor"
    "cita" => "Actas Dermosifiliogr. 2014;105:207-8"
    "abierto" => array:3 [
      "ES" => true
      "ES2" => true
      "LATM" => true
    ]
    "gratuito" => true
    "lecturas" => array:2 [
      "total" => 3851
      "formatos" => array:3 [
        "EPUB" => 37
        "HTML" => 3208
        "PDF" => 606
      ]
    ]
    "en" => array:11 [
      "idiomaDefecto" => true
      "cabecera" => "<span class="elsevierStyleTextfn">Case and Research Letter</span>"
      "titulo" => "Interferon Eyedrops in the Treatment of Basal Cell Carcinoma of the Eyelid"
      "tienePdf" => "en"
      "tieneTextoCompleto" => "en"
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "207"
          "paginaFinal" => "208"
        ]
      ]
      "titulosAlternativos" => array:1 [
        "es" => array:1 [
          "titulo" => "Colirio de interfer&#243;n y carcinoma basocelular palpebral"
        ]
      ]
      "contieneTextoCompleto" => array:1 [
        "en" => true
      ]
      "contienePdf" => array:1 [
        "en" => true
      ]
      "resumenGrafico" => array:2 [
        "original" => 0
        "multimedia" => array:7 [
          "identificador" => "fig0005"
          "etiqueta" => "Figure 1"
          "tipo" => "MULTIMEDIAFIGURA"
          "mostrarFloat" => true
          "mostrarDisplay" => false
          "figura" => array:1 [
            0 => array:4 [
              "imagen" => "gr1.jpeg"
              "Alto" => 629
              "Ancho" => 800
              "Tamanyo" => 101036
            ]
          ]
          "descripcion" => array:1 [
            "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Basal cell carcinoma on the lower margin of the left eyelid&#58; appearance before starting treatment&#46;</p>"
          ]
        ]
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "V&#46;M&#46; Leis-Dosil, I&#46; Prats-Caelles, C&#46; Rubio-Flores"
          "autores" => array:3 [
            0 => array:2 [
              "nombre" => "V&#46;M&#46;"
              "apellidos" => "Leis-Dosil"
            ]
            1 => array:2 [
              "nombre" => "I&#46;"
              "apellidos" => "Prats-Caelles"
            ]
            2 => array:2 [
              "nombre" => "C&#46;"
              "apellidos" => "Rubio-Flores"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "en"
    "Traduccion" => array:1 [
      "es" => array:9 [
        "pii" => "S0001731013001002"
        "doi" => "10.1016/j.ad.2013.02.006"
        "estado" => "S300"
        "subdocumento" => ""
        "abierto" => array:3 [
          "ES" => true
          "ES2" => true
          "LATM" => true
        ]
        "gratuito" => true
        "lecturas" => array:1 [
          "total" => 0
        ]
        "idiomaDefecto" => "es"
        "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0001731013001002?idApp=UINPBA000044"
      ]
    ]
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1578219014000286?idApp=UINPBA000044"
    "url" => "/15782190/0000010500000002/v1_201403090058/S1578219014000286/v1_201403090058/en/main.assets"
  ]
  "itemAnterior" => array:19 [
    "pii" => "S1578219014000316"
    "issn" => "15782190"
    "doi" => "10.1016/j.adengl.2013.02.017"
    "estado" => "S300"
    "fechaPublicacion" => "2014-03-01"
    "aid" => "824"
    "copyright" => "Elsevier Espa&#241;a&#44; S&#46;L&#46; and AEDV"
    "documento" => "simple-article"
    "crossmark" => 0
    "subdocumento" => "cor"
    "cita" => "Actas Dermosifiliogr. 2014;105:202-3"
    "abierto" => array:3 [
      "ES" => true
      "ES2" => true
      "LATM" => true
    ]
    "gratuito" => true
    "lecturas" => array:2 [
      "total" => 2112
      "formatos" => array:3 [
        "EPUB" => 45
        "HTML" => 1429
        "PDF" => 638
      ]
    ]
    "en" => array:10 [
      "idiomaDefecto" => true
      "cabecera" => "<span class="elsevierStyleTextfn">Case and Research Letter</span>"
      "titulo" => "Sevoflurane&#58; A Valid Alternative for the Treatment of Vascular Ulcers&#63;"
      "tienePdf" => "en"
      "tieneTextoCompleto" => "en"
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "202"
          "paginaFinal" => "203"
        ]
      ]
      "titulosAlternativos" => array:1 [
        "es" => array:1 [
          "titulo" => "Sevoflurano&#44; &#191;una alternativa en el tratamiento de las &#250;lceras vasculares&#63;"
        ]
      ]
      "contieneTextoCompleto" => array:1 [
        "en" => true
      ]
      "contienePdf" => array:1 [
        "en" => true
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "R&#46;F&#46; Lafuente-Urrez, Y&#46; Gilaberte"
          "autores" => array:2 [
            0 => array:2 [
              "nombre" => "R&#46;F&#46;"
              "apellidos" => "Lafuente-Urrez"
            ]
            1 => array:2 [
              "nombre" => "Y&#46;"
              "apellidos" => "Gilaberte"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "en"
    "Traduccion" => array:1 [
      "es" => array:9 [
        "pii" => "S0001731013001075"
        "doi" => "10.1016/j.ad.2013.02.010"
        "estado" => "S300"
        "subdocumento" => ""
        "abierto" => array:3 [
          "ES" => true
          "ES2" => true
          "LATM" => true
        ]
        "gratuito" => true
        "lecturas" => array:1 [
          "total" => 0
        ]
        "idiomaDefecto" => "es"
        "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0001731013001075?idApp=UINPBA000044"
      ]
    ]
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1578219014000316?idApp=UINPBA000044"
    "url" => "/15782190/0000010500000002/v1_201403090058/S1578219014000316/v1_201403090058/en/main.assets"
  ]
  "en" => array:16 [
    "idiomaDefecto" => true
    "cabecera" => "<span class="elsevierStyleTextfn">Case and Research Letter</span>"
    "titulo" => "Disseminated Sporotrichosis With Cutaneous and Testicular Involvement"
    "tieneTextoCompleto" => true
    "saludo" => "<span class="elsevierStyleItalic">To the Editor&#58;</span>"
    "paginas" => array:1 [
      0 => array:2 [
        "paginaInicial" => "204"
        "paginaFinal" => "206"
      ]
    ]
    "autores" => array:1 [
      0 => array:4 [
        "autoresLista" => "C&#46;J&#46; Espinoza-Hern&#225;ndez, A&#46; Jes&#250;s-Silva, S&#46; Toussaint-Caire, R&#46; Arenas"
        "autores" => array:4 [
          0 => array:2 [
            "nombre" => "C&#46;J&#46;"
            "apellidos" => "Espinoza-Hern&#225;ndez"
          ]
          1 => array:2 [
            "nombre" => "A&#46;"
            "apellidos" => "Jes&#250;s-Silva"
          ]
          2 => array:2 [
            "nombre" => "S&#46;"
            "apellidos" => "Toussaint-Caire"
          ]
          3 => array:4 [
            "nombre" => "R&#46;"
            "apellidos" => "Arenas"
            "email" => array:1 [
              0 => "rarenas98&#64;hotmail&#46;com"
            ]
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">¿</span>"
                "identificador" => "cor0005"
              ]
            ]
          ]
        ]
        "afiliaciones" => array:1 [
          0 => array:2 [
            "entidad" => "Servicio de Dermatolog&#237;a&#44; Hospital General Dr&#46; Manuel Gea Gonz&#225;lez&#44; M&#233;xico D&#46;F&#46;&#44; Mexico"
            "identificador" => "aff0005"
          ]
        ]
        "correspondencia" => array:1 [
          0 => array:3 [
            "identificador" => "cor0005"
            "etiqueta" => "&#8270;"
            "correspondencia" => "Corresponding Author&#46;"
          ]
        ]
      ]
    ]
    "titulosAlternativos" => array:1 [
      "es" => array:1 [
        "titulo" => "Esporotricosis diseminada con afecci&#243;n cut&#225;nea y testicular"
      ]
    ]
    "resumenGrafico" => array:2 [
      "original" => 0
      "multimedia" => array:7 [
        "identificador" => "fig0010"
        "etiqueta" => "Figure 2"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr2.jpeg"
            "Alto" => 857
            "Ancho" => 1500
            "Tamanyo" => 189235
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">A&#44; PAS-stained smear showing cigar-shaped yeast cells &#40;original magnification &#215;100&#41;&#46; B&#44; Microscopic analysis of the culture showing sympodial conidia &#40;lactophenol blue&#44; original magnification &#215;40&#41;&#46; C&#44; Culture of <span class="elsevierStyleItalic">Sporothrix</span> species&#46;</p>"
        ]
      ]
    ]
    "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">Sporotrichosis is a subcutaneous mycosis caused by the dimorphic fungus <span class="elsevierStyleItalic">Sporothrix schenckii</span>&#44; which can have a subacute or chronic course&#46;<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a> This disease has a worldwide distribution<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a> and is an emerging infection in Europe&#44; where it has become quite common&#46;<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a> The most frequent method of transmission is traumatic inoculation&#46;<a class="elsevierStyleCrossRef" href="#bib0020"><span class="elsevierStyleSup">4</span></a> This polymorphic mycosis has 4 clinical forms&#58; lymphocutaneous&#44; fixed cutaneous&#44; disseminated&#44; and extracutaneous&#46; The extracutaneous and disseminated forms account for 4&#37; of total cases<a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">6</span></a> and most often affect immunocompromised patients&#44; in whom the fungus acts as an opportunistic agent&#46;<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a> Amphotericin B is the treatment of choice for systemic disseminated forms&#46;<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">7</span></a></p><p id="par0010" class="elsevierStylePara elsevierViewall">We report the case of a 54 year-old male construction worker with no relevant medical history except chronic alcohol consumption&#46; The patient reported weight loss and intermittent fever associated with rapidly spreading dermatitis&#44; which had developed 6 months earlier and was characterized by multiple&#44; very painful necrotic pustules and ulcers of varying size with purulent exudate&#44; some with a verrucous surface&#46; The lesions affected a significant percentage of the body surface&#44; exposing muscles and tendons &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a> A-D&#41;&#46; The patient reported that he had undergone a right radical orchiectomy in another hospital for a testicular tumor that was likely malignant&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><p id="par0015" class="elsevierStylePara elsevierViewall">Direct examination of the skin lesions with potassium hydroxide and staining of smears with Gram stain and periodic acid Schiff &#40;PAS&#41; revealed abundant&#44; elongated&#44; cigar-shaped yeast cells &#40;<a class="elsevierStyleCrossRef" href="#fig0010">Fig&#46; 2</a>A&#41;&#46; Microscopic analysis of cells cultured in Sabouraud dextrose agar showed conidia arranged laterally on the hyphae &#40;<a class="elsevierStyleCrossRef" href="#fig0010">Fig&#46; 2</a> B&#41;&#44; and identified the cells as <span class="elsevierStyleItalic">S schenckii</span> &#40;<a class="elsevierStyleCrossRef" href="#fig0010">Fig&#46; 2</a>C&#41;&#46; The following bacterial aggregates were also observed&#58; <span class="elsevierStyleItalic">Acinetobacter baumanni</span> &#40;&#62;<span class="elsevierStyleHsp" style=""></span>250&#44;000 colony-forming units&#41; in a qualitative skin biopsy culture&#59; multiresistant <span class="elsevierStyleItalic">Pseudomonas aeruginosa</span> in pustule exudate&#59; and oxacillin-resistant <span class="elsevierStyleItalic">Staphylococcus haemolyticus</span> in a blood culture&#46; The sporotrichin skin test was negative&#46;</p><elsevierMultimedia ident="fig0010"></elsevierMultimedia><p id="par0020" class="elsevierStylePara elsevierViewall">The skin biopsy showed nodular and diffuse inflammatory infiltrate&#44; which was composed of lymphocytes&#44; epithelioid histiocytes&#44; multinucleated giant cells&#44; and neutrophils&#44; and produced suppurative granulomas and tissue necrosis &#40;<a class="elsevierStyleCrossRef" href="#fig0015">Figs&#46; 3</a>A and B&#41;&#46; PAS and Grocott Gomori staining revealed abundant yeast cells&#44; both round and elongated &#40;<a class="elsevierStyleCrossRef" href="#fig0015">Figs&#46; 3</a><span class="elsevierStyleHsp" style=""></span>C and D&#41;&#46;</p><elsevierMultimedia ident="fig0015"></elsevierMultimedia><p id="par0025" class="elsevierStylePara elsevierViewall">Histology of the tissue excised in the orchiectomy revealed similar findings&#59; chronic granulomatous inflammation was observed with multinucleated giant cells&#44; necrosis&#44; and polymorphonuclear infiltration &#40;<a class="elsevierStyleCrossRef" href="#fig0020">Figs&#46; 4</a> A and B&#41;&#46; Staining showed spherical and cigar-shaped spores consistent with sporotrichosis &#40;<a class="elsevierStyleCrossRef" href="#fig0020">Figs&#46; 4</a><span class="elsevierStyleHsp" style=""></span>C and D&#41;&#46;</p><elsevierMultimedia ident="fig0020"></elsevierMultimedia><p id="par0030" class="elsevierStylePara elsevierViewall">Tumor staging ruled out fungal invasion of other organs&#44; and HIV serology was negative&#46;</p><p id="par0035" class="elsevierStylePara elsevierViewall">The patient&#8217; wounds were dressed and he was treated with amphotericin B deoxycholate for 14 days &#40;total cumulative dose of 1&#46;68<span class="elsevierStyleHsp" style=""></span>g&#41; in addition to antibiotics&#46; The clinical course of infection was prolonged due to several complications related to treatment&#44; associated infections&#44; and the disease itself&#46; These included septic shock&#44; nephrotoxicity &#40;acute renal failure&#44; hypokalemia&#44; hypomagnesemia&#44; metabolic acidosis&#41;&#44; liver failure&#44; and disseminated intravascular coagulation&#46; The patient died due to severe hemodynamic compromise&#46;</p><p id="par0040" class="elsevierStylePara elsevierViewall">Sporotrichosis is caused by the dimorphic fungus <span class="elsevierStyleItalic">S schenckii</span>&#46;<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a> The most common presentation is lymphocutaneous&#59; extracutaneous forms are rare&#44; and are more prevalent in immunosuppressed patients&#46;<a class="elsevierStyleCrossRef" href="#bib0025"><span class="elsevierStyleSup">5</span></a></p><p id="par0045" class="elsevierStylePara elsevierViewall">The case described here was classified as systemic disseminated sporotrichosis with additional extracutaneous involvement&#44; with disseminated skin lesions&#44; general malaise and internal organ involvement&#46; This form is most common in immunocompromised patients&#46;</p><p id="par0050" class="elsevierStylePara elsevierViewall">The fungal infection was highly invasive&#44; not only in terms of its cutaneous extension and testicular involvement&#44; but also the degree of necrosis&#44; depth of invasion&#44; and the destruction of adjacent muscles and tendons&#46; The sporotrichin skin test was anergic&#44; indicating a poor immune response to fungal invasion by the patient&#46; The only immunosuppression-associated factor detected was chronic alcoholism&#46; The patient had also recently undergone orchiectomy at another institution due to clinical suspicion of a malignant testicular tumor&#44; without prior confirmation of the nature of the lesion&#46;</p><p id="par0055" class="elsevierStylePara elsevierViewall">It was not possible to determine the mechanism of infection&#44; but given the patient&#8217; profession he may have acquired the microorganism via cutaneous inoculation&#44; as the lesions first appeared on the left hand&#44; and later spread throughout the body by hematogenous dissemination&#46;</p><p id="par0060" class="elsevierStylePara elsevierViewall">Sporotrichosis is definitively diagnosed by culture of the fungus obtained from a skin biopsy&#46; Histology is usually not diagnostic&#44; as the yeast is present in small amounts&#46;<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a> However&#44; in this patient&#44; a large number of fungal elements were detected in the cutaneous and testicular biopsies&#46;</p><p id="par0065" class="elsevierStylePara elsevierViewall">The treatment of choice for extracutaneous and disseminated forms of sporotrichosis is amphotericin B&#44; followed by long-term itraconazole administration in immunocompromised patients&#46;<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">7</span></a></p><p id="par0070" class="elsevierStylePara elsevierViewall">In summary&#44; our patient&#8217; chronic alcohol abuse led to a state of severe immunosuppression&#44; favoring the fulminant course of sporotrichosis with significant fungal invasion&#44; which&#44; together with a lack of prior clinical suspicion as well as complications associated with the treatment&#44; concurrent bacterial infections&#44; and the mycosis itself&#44; resulted in the patient&#39;s death&#46;</p></span>"
    "pdfFichero" => "main.pdf"
    "tienePdf" => true
    "NotaPie" => array:1 [
      0 => array:2 [
        "etiqueta" => "&#9734;"
        "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Please cite this article as&#58; Espinoza-Hern&#225;ndez C&#44; Jes&#250;s-Silva A&#44; Toussaint-Caire S&#44; Arenas R&#46; Esporotricosis diseminada con afecci&#243;n cut&#225;nea y testicular&#46; Actas Dermosifiliogr&#46; 2014&#59;105&#58;204&#8211;206&#46;</p>"
      ]
    ]
    "multimedia" => array:4 [
      0 => array:7 [
        "identificador" => "fig0005"
        "etiqueta" => "Figure 1"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr1.jpeg"
            "Alto" => 1064
            "Ancho" => 1501
            "Tamanyo" => 232346
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">A&#44; Necrotic pustules and papules on the trunk and lower extremities&#46; B&#44; Ulcers and extensive necrosis on the head&#46; C and D&#44; Large ulcers on the left forearm with exposed tendons and muscle&#46;</p>"
        ]
      ]
      1 => array:7 [
        "identificador" => "fig0010"
        "etiqueta" => "Figure 2"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr2.jpeg"
            "Alto" => 857
            "Ancho" => 1500
            "Tamanyo" => 189235
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">A&#44; PAS-stained smear showing cigar-shaped yeast cells &#40;original magnification &#215;100&#41;&#46; B&#44; Microscopic analysis of the culture showing sympodial conidia &#40;lactophenol blue&#44; original magnification &#215;40&#41;&#46; C&#44; Culture of <span class="elsevierStyleItalic">Sporothrix</span> species&#46;</p>"
        ]
      ]
      2 => array:7 [
        "identificador" => "fig0015"
        "etiqueta" => "Figure 3"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr3.jpeg"
            "Alto" => 840
            "Ancho" => 1500
            "Tamanyo" => 301557
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">A&#44; Histopathology of skin samples with suppurative granuloma containing lymphocytes&#44; epithelioid histiocytes&#44; and multinucleated giant cells &#40;hematoxylin-eosin&#44; original magnification &#215;5&#41;&#46; B&#44; Higher magnification image showing phagocytosed yeast cells &#40;hematoxylin-eosin&#44; original magnification &#215;40&#41;&#46; C&#44; Note the abundance of yeast cells &#40;PAS&#44; original magnification &#215;20&#41;&#46; D&#44; Ovoid and cigar-shaped yeast cells &#40;Gomori-Grocott&#44; original magnification &#215;20&#41;&#46;</p>"
        ]
      ]
      3 => array:7 [
        "identificador" => "fig0020"
        "etiqueta" => "Figure 4"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr4.jpeg"
            "Alto" => 805
            "Ancho" => 1500
            "Tamanyo" => 296530
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">Testicular biopsy&#46; A&#44; Substitution of the testicular parenchyma with chronic granulomatous inflammation with multinucleated giant cells&#44; areas of necrosis&#44; and polymorphonuclear infiltration &#40;hematoxylin-eosin&#44; original magnification &#215;5&#41;&#46; B&#44; Higher magnification image showing abundant ovoid yeast cells &#40;hematoxylin-eosin&#44; original magnification &#215;40&#41;&#46; C and D&#44; Spherical and cigar-shaped spores &#40;PAS and Gomori Grocott&#44; original magnification &#215;20&#41;&#46;</p>"
        ]
      ]
    ]
    "bibliografia" => array:2 [
      "titulo" => "References"
      "seccion" => array:1 [
        0 => array:2 [
          "identificador" => "bibs0005"
          "bibliografiaReferencia" => array:7 [
            0 => array:3 [
              "identificador" => "bib0005"
              "etiqueta" => "1"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Sporotrichosis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "R&#46; Arenas"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "LibroEditado" => array:5 [
                        "titulo" => "Microbiology and microbial infections"
                        "paginaInicial" => "367"
                        "paginaFinal" => "384"
                        "edicion" => "10th ed"
                        "serieFecha" => "2005"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            1 => array:3 [
              "identificador" => "bib0010"
              "etiqueta" => "2"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Esporotricosis&#58; prevalencia&#44; perfil cl&#237;nico y epidemiol&#243;gico en un centro de referencia en Colombia"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "G&#46; Rubio"
                            1 => "G&#46; S&#225;nchez"
                            2 => "L&#46; Porras"
                            3 => "Z&#46; Alvarado"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.riam.2010.01.001"
                      "Revista" => array:6 [
                        "tituloSerie" => "Rev Iberoam Micol"
                        "fecha" => "2010"
                        "volumen" => "27"
                        "paginaInicial" => "75"
                        "paginaFinal" => "79"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/20346295"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            2 => array:3 [
              "identificador" => "bib0015"
              "etiqueta" => "3"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Esporotricosis en la provincia de Sevilla &#40;Espa&#241;a&#41;"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "T&#46; Ojeda"
                            1 => "A&#46; Rodr&#237;guez-Pichardo"
                            2 => "A&#46;I&#46; Su&#225;rez"
                            3 => "F&#46;M&#46; Camacho"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.eimc.2010.06.011"
                      "Revista" => array:6 [
                        "tituloSerie" => "Enferm Infecc Microbiol Clin"
                        "fecha" => "2011"
                        "volumen" => "29"
                        "paginaInicial" => "233"
                        "paginaFinal" => "234"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/21330011"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            3 => array:3 [
              "identificador" => "bib0020"
              "etiqueta" => "4"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Sporothrix schenckii and sporotrichosis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "L&#46;M&#46; Lopes"
                            1 => "A&#46; Schubach"
                            2 => "R&#46;O&#46; Costa"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "An Acad Bras Cien"
                        "fecha" => "2006"
                        "volumen" => "78"
                        "paginaInicial" => "293"
                        "paginaFinal" => "308"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            4 => array:3 [
              "identificador" => "bib0025"
              "etiqueta" => "5"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Clasificaci&#243;n de la esporotricosis&#46; Una propuesta con base en el comportamiento inmunol&#243;gico"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "A&#46; Sa&#250;l"
                            1 => "A&#46; Bonifaz"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Dermatolog&#237;a Rev Mex"
                        "fecha" => "2011"
                        "volumen" => "55"
                        "paginaInicial" => "200"
                        "paginaFinal" => "208"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            5 => array:3 [
              "identificador" => "bib0030"
              "etiqueta" => "6"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Sporotrichosis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "E&#46; V&#225;zquez-del Mercado"
                            1 => "R&#46; Arenas"
                            2 => "C&#46; Padilla-Desgarenes"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.clindermatol.2011.09.017"
                      "Revista" => array:7 [
                        "tituloSerie" => "Clin Dermatol"
                        "fecha" => "2012"
                        "volumen" => "30"
                        "paginaInicial" => "437"
                        "paginaFinal" => "443"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/22682194"
                            "web" => "Medline"
                          ]
                        ]
                        "itemHostRev" => array:3 [
                          "pii" => "S1552526010000142"
                          "estado" => "S300"
                          "issn" => "15525260"
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            6 => array:3 [
              "identificador" => "bib0035"
              "etiqueta" => "7"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Clinical Practice Guidelines for the Management of Sporotrichosis&#58; 2007 Update by the Infectious Diseases Society of America"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "C&#46; Kauffman"
                            1 => "B&#46; Bustamante"
                            2 => "S&#46; Chapman"
                            3 => "E&#46; Pappas"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:4 [
                        "tituloSerie" => "CID"
                        "fecha" => "2007"
                        "paginaInicial" => "1255"
                        "paginaFinal" => "1265"
                      ]
                    ]
                  ]
                ]
              ]
            ]
          ]
        ]
      ]
    ]
    "agradecimientos" => array:1 [
      0 => array:4 [
        "identificador" => "xack75381"
        "titulo" => "Acknowledgements"
        "texto" => "<p id="par0075" class="elsevierStylePara elsevierViewall">We thank Dr&#46; Jos&#233; G&#46; Chanona Vilchis&#44; Head of the Department of Surgical Pathology of the Instituto Nacional de Cancerolog&#237;a&#44; for providing testicular biopsy samples and histological descriptions&#46;</p> <p id="par0080" class="elsevierStylePara elsevierViewall">We also thank Dr&#46; Diana Vilar Compte of the Infectious Diseases Service at the Hospital General Dr&#46; Manuel Gea Gonz&#225;lez for microbiological identification of superadded bacterial infections&#44; and Dr&#46; Horacio Vidrio Morgado&#44; Surgical Oncology Resident at the Instituto Nacional de Cancerolog&#237;a&#44; and Dr&#46; Alberto de los R&#237;os&#44; Internal Medicine Resident at the Hospital General Dr&#46; Manuel Gea Gonz&#225;lez&#44; for their role in the metabolic and surgical management of the patient&#46;</p>"
        "vista" => "all"
      ]
    ]
  ]
  "idiomaDefecto" => "en"
  "url" => "/15782190/0000010500000002/v1_201403090058/S1578219014000274/v1_201403090058/en/main.assets"
  "Apartado" => array:4 [
    "identificador" => "6157"
    "tipo" => "SECCION"
    "en" => array:2 [
      "titulo" => "Case and Research Letters"
      "idiomaDefecto" => true
    ]
    "idiomaDefecto" => "en"
  ]
  "PDF" => "https://static.elsevier.es/multimedia/15782190/0000010500000002/v1_201403090058/S1578219014000274/v1_201403090058/en/main.pdf?idApp=UINPBA000044&text.app=https://actasdermo.org/"
  "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1578219014000274?idApp=UINPBA000044"
]
Compartir
Información de la revista

Estadísticas

Siga este enlace para acceder al texto completo del artículo

Case and Research Letter
Disseminated Sporotrichosis With Cutaneous and Testicular Involvement
Esporotricosis diseminada con afección cutánea y testicular
C.J. Espinoza-Hernández, A. Jesús-Silva, S. Toussaint-Caire, R. Arenas
Autor para correspondencia
rarenas98@hotmail.com

Corresponding Author.
Servicio de Dermatología, Hospital General Dr. Manuel Gea González, México D.F., Mexico
Leído
9508
Veces
se ha leído el artículo
2461
Total PDF
7047
Total HTML
Compartir estadísticas
 array:24 [
  "pii" => "S1578219014000274"
  "issn" => "15782190"
  "doi" => "10.1016/j.adengl.2013.02.015"
  "estado" => "S300"
  "fechaPublicacion" => "2014-03-01"
  "aid" => "808"
  "copyright" => "Elsevier Espa&#241;a&#44; S&#46;L&#46; and AEDV"
  "copyrightAnyo" => "2012"
  "documento" => "simple-article"
  "crossmark" => 0
  "subdocumento" => "cor"
  "cita" => "Actas Dermosifiliogr. 2014;105:204-6"
  "abierto" => array:3 [
    "ES" => true
    "ES2" => true
    "LATM" => true
  ]
  "gratuito" => true
  "lecturas" => array:2 [
    "total" => 2965
    "formatos" => array:3 [
      "EPUB" => 42
      "HTML" => 2515
      "PDF" => 408
    ]
  ]
  "Traduccion" => array:1 [
    "es" => array:19 [
      "pii" => "S0001731013000616"
      "issn" => "00017310"
      "doi" => "10.1016/j.ad.2013.02.002"
      "estado" => "S300"
      "fechaPublicacion" => "2014-03-01"
      "aid" => "808"
      "copyright" => "Elsevier Espa&#241;a&#44; S&#46;L&#46; y AEDV"
      "documento" => "simple-article"
      "crossmark" => 0
      "subdocumento" => "cor"
      "cita" => "Actas Dermosifiliogr. 2014;105:204-6"
      "abierto" => array:3 [
        "ES" => true
        "ES2" => true
        "LATM" => true
      ]
      "gratuito" => true
      "lecturas" => array:2 [
        "total" => 3182
        "formatos" => array:3 [
          "EPUB" => 2
          "HTML" => 2365
          "PDF" => 815
        ]
      ]
      "es" => array:11 [
        "idiomaDefecto" => true
        "cabecera" => "<span class="elsevierStyleTextfn">Carta cient&#237;fico-cl&#237;nica</span>"
        "titulo" => "Esporotricosis diseminada con afecci&#243;n cut&#225;nea y testicular"
        "tienePdf" => "es"
        "tieneTextoCompleto" => "es"
        "paginas" => array:1 [
          0 => array:2 [
            "paginaInicial" => "204"
            "paginaFinal" => "206"
          ]
        ]
        "titulosAlternativos" => array:1 [
          "en" => array:1 [
            "titulo" => "Disseminated Sporotrichosis With Cutaneous and Testicular Involvement"
          ]
        ]
        "contieneTextoCompleto" => array:1 [
          "es" => true
        ]
        "contienePdf" => array:1 [
          "es" => true
        ]
        "resumenGrafico" => array:2 [
          "original" => 0
          "multimedia" => array:7 [
            "identificador" => "fig0005"
            "etiqueta" => "Figura 1"
            "tipo" => "MULTIMEDIAFIGURA"
            "mostrarFloat" => true
            "mostrarDisplay" => false
            "figura" => array:1 [
              0 => array:4 [
                "imagen" => "gr1.jpeg"
                "Alto" => 1064
                "Ancho" => 1501
                "Tamanyo" => 214964
              ]
            ]
            "descripcion" => array:1 [
              "es" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">A&#46; P&#250;stulas y p&#225;pulas necr&#243;ticas en el tronco y las extremidades inferiores&#46; B&#46; &#218;lceras y necrosis extensa en la cabeza&#46; C y D&#46; Grandes &#250;lceras en el antebrazo izquierdo con exposici&#243;n de tendones y m&#250;sculo&#46;</p>"
            ]
          ]
        ]
        "autores" => array:1 [
          0 => array:2 [
            "autoresLista" => "C&#46;J&#46; Espinoza-Hern&#225;ndez, A&#46; Jes&#250;s-Silva, S&#46; Toussaint-Caire, R&#46; Arenas"
            "autores" => array:4 [
              0 => array:2 [
                "nombre" => "C&#46;J&#46;"
                "apellidos" => "Espinoza-Hern&#225;ndez"
              ]
              1 => array:2 [
                "nombre" => "A&#46;"
                "apellidos" => "Jes&#250;s-Silva"
              ]
              2 => array:2 [
                "nombre" => "S&#46;"
                "apellidos" => "Toussaint-Caire"
              ]
              3 => array:2 [
                "nombre" => "R&#46;"
                "apellidos" => "Arenas"
              ]
            ]
          ]
        ]
      ]
      "idiomaDefecto" => "es"
      "Traduccion" => array:1 [
        "en" => array:9 [
          "pii" => "S1578219014000274"
          "doi" => "10.1016/j.adengl.2013.02.015"
          "estado" => "S300"
          "subdocumento" => ""
          "abierto" => array:3 [
            "ES" => true
            "ES2" => true
            "LATM" => true
          ]
          "gratuito" => true
          "lecturas" => array:1 [
            "total" => 0
          ]
          "idiomaDefecto" => "en"
          "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1578219014000274?idApp=UINPBA000044"
        ]
      ]
      "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0001731013000616?idApp=UINPBA000044"
      "url" => "/00017310/0000010500000002/v1_201403120205/S0001731013000616/v1_201403120205/es/main.assets"
    ]
  ]
  "itemSiguiente" => array:19 [
    "pii" => "S1578219014000286"
    "issn" => "15782190"
    "doi" => "10.1016/j.adengl.2013.02.016"
    "estado" => "S300"
    "fechaPublicacion" => "2014-03-01"
    "aid" => "817"
    "copyright" => "Elsevier Espa&#241;a&#44; S&#46;L&#46; and AEDV"
    "documento" => "simple-article"
    "crossmark" => 0
    "subdocumento" => "cor"
    "cita" => "Actas Dermosifiliogr. 2014;105:207-8"
    "abierto" => array:3 [
      "ES" => true
      "ES2" => true
      "LATM" => true
    ]
    "gratuito" => true
    "lecturas" => array:2 [
      "total" => 3851
      "formatos" => array:3 [
        "EPUB" => 37
        "HTML" => 3208
        "PDF" => 606
      ]
    ]
    "en" => array:11 [
      "idiomaDefecto" => true
      "cabecera" => "<span class="elsevierStyleTextfn">Case and Research Letter</span>"
      "titulo" => "Interferon Eyedrops in the Treatment of Basal Cell Carcinoma of the Eyelid"
      "tienePdf" => "en"
      "tieneTextoCompleto" => "en"
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "207"
          "paginaFinal" => "208"
        ]
      ]
      "titulosAlternativos" => array:1 [
        "es" => array:1 [
          "titulo" => "Colirio de interfer&#243;n y carcinoma basocelular palpebral"
        ]
      ]
      "contieneTextoCompleto" => array:1 [
        "en" => true
      ]
      "contienePdf" => array:1 [
        "en" => true
      ]
      "resumenGrafico" => array:2 [
        "original" => 0
        "multimedia" => array:7 [
          "identificador" => "fig0005"
          "etiqueta" => "Figure 1"
          "tipo" => "MULTIMEDIAFIGURA"
          "mostrarFloat" => true
          "mostrarDisplay" => false
          "figura" => array:1 [
            0 => array:4 [
              "imagen" => "gr1.jpeg"
              "Alto" => 629
              "Ancho" => 800
              "Tamanyo" => 101036
            ]
          ]
          "descripcion" => array:1 [
            "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Basal cell carcinoma on the lower margin of the left eyelid&#58; appearance before starting treatment&#46;</p>"
          ]
        ]
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "V&#46;M&#46; Leis-Dosil, I&#46; Prats-Caelles, C&#46; Rubio-Flores"
          "autores" => array:3 [
            0 => array:2 [
              "nombre" => "V&#46;M&#46;"
              "apellidos" => "Leis-Dosil"
            ]
            1 => array:2 [
              "nombre" => "I&#46;"
              "apellidos" => "Prats-Caelles"
            ]
            2 => array:2 [
              "nombre" => "C&#46;"
              "apellidos" => "Rubio-Flores"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "en"
    "Traduccion" => array:1 [
      "es" => array:9 [
        "pii" => "S0001731013001002"
        "doi" => "10.1016/j.ad.2013.02.006"
        "estado" => "S300"
        "subdocumento" => ""
        "abierto" => array:3 [
          "ES" => true
          "ES2" => true
          "LATM" => true
        ]
        "gratuito" => true
        "lecturas" => array:1 [
          "total" => 0
        ]
        "idiomaDefecto" => "es"
        "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0001731013001002?idApp=UINPBA000044"
      ]
    ]
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1578219014000286?idApp=UINPBA000044"
    "url" => "/15782190/0000010500000002/v1_201403090058/S1578219014000286/v1_201403090058/en/main.assets"
  ]
  "itemAnterior" => array:19 [
    "pii" => "S1578219014000316"
    "issn" => "15782190"
    "doi" => "10.1016/j.adengl.2013.02.017"
    "estado" => "S300"
    "fechaPublicacion" => "2014-03-01"
    "aid" => "824"
    "copyright" => "Elsevier Espa&#241;a&#44; S&#46;L&#46; and AEDV"
    "documento" => "simple-article"
    "crossmark" => 0
    "subdocumento" => "cor"
    "cita" => "Actas Dermosifiliogr. 2014;105:202-3"
    "abierto" => array:3 [
      "ES" => true
      "ES2" => true
      "LATM" => true
    ]
    "gratuito" => true
    "lecturas" => array:2 [
      "total" => 2112
      "formatos" => array:3 [
        "EPUB" => 45
        "HTML" => 1429
        "PDF" => 638
      ]
    ]
    "en" => array:10 [
      "idiomaDefecto" => true
      "cabecera" => "<span class="elsevierStyleTextfn">Case and Research Letter</span>"
      "titulo" => "Sevoflurane&#58; A Valid Alternative for the Treatment of Vascular Ulcers&#63;"
      "tienePdf" => "en"
      "tieneTextoCompleto" => "en"
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "202"
          "paginaFinal" => "203"
        ]
      ]
      "titulosAlternativos" => array:1 [
        "es" => array:1 [
          "titulo" => "Sevoflurano&#44; &#191;una alternativa en el tratamiento de las &#250;lceras vasculares&#63;"
        ]
      ]
      "contieneTextoCompleto" => array:1 [
        "en" => true
      ]
      "contienePdf" => array:1 [
        "en" => true
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "R&#46;F&#46; Lafuente-Urrez, Y&#46; Gilaberte"
          "autores" => array:2 [
            0 => array:2 [
              "nombre" => "R&#46;F&#46;"
              "apellidos" => "Lafuente-Urrez"
            ]
            1 => array:2 [
              "nombre" => "Y&#46;"
              "apellidos" => "Gilaberte"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "en"
    "Traduccion" => array:1 [
      "es" => array:9 [
        "pii" => "S0001731013001075"
        "doi" => "10.1016/j.ad.2013.02.010"
        "estado" => "S300"
        "subdocumento" => ""
        "abierto" => array:3 [
          "ES" => true
          "ES2" => true
          "LATM" => true
        ]
        "gratuito" => true
        "lecturas" => array:1 [
          "total" => 0
        ]
        "idiomaDefecto" => "es"
        "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0001731013001075?idApp=UINPBA000044"
      ]
    ]
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1578219014000316?idApp=UINPBA000044"
    "url" => "/15782190/0000010500000002/v1_201403090058/S1578219014000316/v1_201403090058/en/main.assets"
  ]
  "en" => array:16 [
    "idiomaDefecto" => true
    "cabecera" => "<span class="elsevierStyleTextfn">Case and Research Letter</span>"
    "titulo" => "Disseminated Sporotrichosis With Cutaneous and Testicular Involvement"
    "tieneTextoCompleto" => true
    "saludo" => "<span class="elsevierStyleItalic">To the Editor&#58;</span>"
    "paginas" => array:1 [
      0 => array:2 [
        "paginaInicial" => "204"
        "paginaFinal" => "206"
      ]
    ]
    "autores" => array:1 [
      0 => array:4 [
        "autoresLista" => "C&#46;J&#46; Espinoza-Hern&#225;ndez, A&#46; Jes&#250;s-Silva, S&#46; Toussaint-Caire, R&#46; Arenas"
        "autores" => array:4 [
          0 => array:2 [
            "nombre" => "C&#46;J&#46;"
            "apellidos" => "Espinoza-Hern&#225;ndez"
          ]
          1 => array:2 [
            "nombre" => "A&#46;"
            "apellidos" => "Jes&#250;s-Silva"
          ]
          2 => array:2 [
            "nombre" => "S&#46;"
            "apellidos" => "Toussaint-Caire"
          ]
          3 => array:4 [
            "nombre" => "R&#46;"
            "apellidos" => "Arenas"
            "email" => array:1 [
              0 => "rarenas98&#64;hotmail&#46;com"
            ]
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">¿</span>"
                "identificador" => "cor0005"
              ]
            ]
          ]
        ]
        "afiliaciones" => array:1 [
          0 => array:2 [
            "entidad" => "Servicio de Dermatolog&#237;a&#44; Hospital General Dr&#46; Manuel Gea Gonz&#225;lez&#44; M&#233;xico D&#46;F&#46;&#44; Mexico"
            "identificador" => "aff0005"
          ]
        ]
        "correspondencia" => array:1 [
          0 => array:3 [
            "identificador" => "cor0005"
            "etiqueta" => "&#8270;"
            "correspondencia" => "Corresponding Author&#46;"
          ]
        ]
      ]
    ]
    "titulosAlternativos" => array:1 [
      "es" => array:1 [
        "titulo" => "Esporotricosis diseminada con afecci&#243;n cut&#225;nea y testicular"
      ]
    ]
    "resumenGrafico" => array:2 [
      "original" => 0
      "multimedia" => array:7 [
        "identificador" => "fig0010"
        "etiqueta" => "Figure 2"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr2.jpeg"
            "Alto" => 857
            "Ancho" => 1500
            "Tamanyo" => 189235
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">A&#44; PAS-stained smear showing cigar-shaped yeast cells &#40;original magnification &#215;100&#41;&#46; B&#44; Microscopic analysis of the culture showing sympodial conidia &#40;lactophenol blue&#44; original magnification &#215;40&#41;&#46; C&#44; Culture of <span class="elsevierStyleItalic">Sporothrix</span> species&#46;</p>"
        ]
      ]
    ]
    "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">Sporotrichosis is a subcutaneous mycosis caused by the dimorphic fungus <span class="elsevierStyleItalic">Sporothrix schenckii</span>&#44; which can have a subacute or chronic course&#46;<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a> This disease has a worldwide distribution<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a> and is an emerging infection in Europe&#44; where it has become quite common&#46;<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a> The most frequent method of transmission is traumatic inoculation&#46;<a class="elsevierStyleCrossRef" href="#bib0020"><span class="elsevierStyleSup">4</span></a> This polymorphic mycosis has 4 clinical forms&#58; lymphocutaneous&#44; fixed cutaneous&#44; disseminated&#44; and extracutaneous&#46; The extracutaneous and disseminated forms account for 4&#37; of total cases<a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">6</span></a> and most often affect immunocompromised patients&#44; in whom the fungus acts as an opportunistic agent&#46;<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a> Amphotericin B is the treatment of choice for systemic disseminated forms&#46;<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">7</span></a></p><p id="par0010" class="elsevierStylePara elsevierViewall">We report the case of a 54 year-old male construction worker with no relevant medical history except chronic alcohol consumption&#46; The patient reported weight loss and intermittent fever associated with rapidly spreading dermatitis&#44; which had developed 6 months earlier and was characterized by multiple&#44; very painful necrotic pustules and ulcers of varying size with purulent exudate&#44; some with a verrucous surface&#46; The lesions affected a significant percentage of the body surface&#44; exposing muscles and tendons &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a> A-D&#41;&#46; The patient reported that he had undergone a right radical orchiectomy in another hospital for a testicular tumor that was likely malignant&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><p id="par0015" class="elsevierStylePara elsevierViewall">Direct examination of the skin lesions with potassium hydroxide and staining of smears with Gram stain and periodic acid Schiff &#40;PAS&#41; revealed abundant&#44; elongated&#44; cigar-shaped yeast cells &#40;<a class="elsevierStyleCrossRef" href="#fig0010">Fig&#46; 2</a>A&#41;&#46; Microscopic analysis of cells cultured in Sabouraud dextrose agar showed conidia arranged laterally on the hyphae &#40;<a class="elsevierStyleCrossRef" href="#fig0010">Fig&#46; 2</a> B&#41;&#44; and identified the cells as <span class="elsevierStyleItalic">S schenckii</span> &#40;<a class="elsevierStyleCrossRef" href="#fig0010">Fig&#46; 2</a>C&#41;&#46; The following bacterial aggregates were also observed&#58; <span class="elsevierStyleItalic">Acinetobacter baumanni</span> &#40;&#62;<span class="elsevierStyleHsp" style=""></span>250&#44;000 colony-forming units&#41; in a qualitative skin biopsy culture&#59; multiresistant <span class="elsevierStyleItalic">Pseudomonas aeruginosa</span> in pustule exudate&#59; and oxacillin-resistant <span class="elsevierStyleItalic">Staphylococcus haemolyticus</span> in a blood culture&#46; The sporotrichin skin test was negative&#46;</p><elsevierMultimedia ident="fig0010"></elsevierMultimedia><p id="par0020" class="elsevierStylePara elsevierViewall">The skin biopsy showed nodular and diffuse inflammatory infiltrate&#44; which was composed of lymphocytes&#44; epithelioid histiocytes&#44; multinucleated giant cells&#44; and neutrophils&#44; and produced suppurative granulomas and tissue necrosis &#40;<a class="elsevierStyleCrossRef" href="#fig0015">Figs&#46; 3</a>A and B&#41;&#46; PAS and Grocott Gomori staining revealed abundant yeast cells&#44; both round and elongated &#40;<a class="elsevierStyleCrossRef" href="#fig0015">Figs&#46; 3</a><span class="elsevierStyleHsp" style=""></span>C and D&#41;&#46;</p><elsevierMultimedia ident="fig0015"></elsevierMultimedia><p id="par0025" class="elsevierStylePara elsevierViewall">Histology of the tissue excised in the orchiectomy revealed similar findings&#59; chronic granulomatous inflammation was observed with multinucleated giant cells&#44; necrosis&#44; and polymorphonuclear infiltration &#40;<a class="elsevierStyleCrossRef" href="#fig0020">Figs&#46; 4</a> A and B&#41;&#46; Staining showed spherical and cigar-shaped spores consistent with sporotrichosis &#40;<a class="elsevierStyleCrossRef" href="#fig0020">Figs&#46; 4</a><span class="elsevierStyleHsp" style=""></span>C and D&#41;&#46;</p><elsevierMultimedia ident="fig0020"></elsevierMultimedia><p id="par0030" class="elsevierStylePara elsevierViewall">Tumor staging ruled out fungal invasion of other organs&#44; and HIV serology was negative&#46;</p><p id="par0035" class="elsevierStylePara elsevierViewall">The patient&#8217; wounds were dressed and he was treated with amphotericin B deoxycholate for 14 days &#40;total cumulative dose of 1&#46;68<span class="elsevierStyleHsp" style=""></span>g&#41; in addition to antibiotics&#46; The clinical course of infection was prolonged due to several complications related to treatment&#44; associated infections&#44; and the disease itself&#46; These included septic shock&#44; nephrotoxicity &#40;acute renal failure&#44; hypokalemia&#44; hypomagnesemia&#44; metabolic acidosis&#41;&#44; liver failure&#44; and disseminated intravascular coagulation&#46; The patient died due to severe hemodynamic compromise&#46;</p><p id="par0040" class="elsevierStylePara elsevierViewall">Sporotrichosis is caused by the dimorphic fungus <span class="elsevierStyleItalic">S schenckii</span>&#46;<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a> The most common presentation is lymphocutaneous&#59; extracutaneous forms are rare&#44; and are more prevalent in immunosuppressed patients&#46;<a class="elsevierStyleCrossRef" href="#bib0025"><span class="elsevierStyleSup">5</span></a></p><p id="par0045" class="elsevierStylePara elsevierViewall">The case described here was classified as systemic disseminated sporotrichosis with additional extracutaneous involvement&#44; with disseminated skin lesions&#44; general malaise and internal organ involvement&#46; This form is most common in immunocompromised patients&#46;</p><p id="par0050" class="elsevierStylePara elsevierViewall">The fungal infection was highly invasive&#44; not only in terms of its cutaneous extension and testicular involvement&#44; but also the degree of necrosis&#44; depth of invasion&#44; and the destruction of adjacent muscles and tendons&#46; The sporotrichin skin test was anergic&#44; indicating a poor immune response to fungal invasion by the patient&#46; The only immunosuppression-associated factor detected was chronic alcoholism&#46; The patient had also recently undergone orchiectomy at another institution due to clinical suspicion of a malignant testicular tumor&#44; without prior confirmation of the nature of the lesion&#46;</p><p id="par0055" class="elsevierStylePara elsevierViewall">It was not possible to determine the mechanism of infection&#44; but given the patient&#8217; profession he may have acquired the microorganism via cutaneous inoculation&#44; as the lesions first appeared on the left hand&#44; and later spread throughout the body by hematogenous dissemination&#46;</p><p id="par0060" class="elsevierStylePara elsevierViewall">Sporotrichosis is definitively diagnosed by culture of the fungus obtained from a skin biopsy&#46; Histology is usually not diagnostic&#44; as the yeast is present in small amounts&#46;<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a> However&#44; in this patient&#44; a large number of fungal elements were detected in the cutaneous and testicular biopsies&#46;</p><p id="par0065" class="elsevierStylePara elsevierViewall">The treatment of choice for extracutaneous and disseminated forms of sporotrichosis is amphotericin B&#44; followed by long-term itraconazole administration in immunocompromised patients&#46;<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">7</span></a></p><p id="par0070" class="elsevierStylePara elsevierViewall">In summary&#44; our patient&#8217; chronic alcohol abuse led to a state of severe immunosuppression&#44; favoring the fulminant course of sporotrichosis with significant fungal invasion&#44; which&#44; together with a lack of prior clinical suspicion as well as complications associated with the treatment&#44; concurrent bacterial infections&#44; and the mycosis itself&#44; resulted in the patient&#39;s death&#46;</p></span>"
    "pdfFichero" => "main.pdf"
    "tienePdf" => true
    "NotaPie" => array:1 [
      0 => array:2 [
        "etiqueta" => "&#9734;"
        "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Please cite this article as&#58; Espinoza-Hern&#225;ndez C&#44; Jes&#250;s-Silva A&#44; Toussaint-Caire S&#44; Arenas R&#46; Esporotricosis diseminada con afecci&#243;n cut&#225;nea y testicular&#46; Actas Dermosifiliogr&#46; 2014&#59;105&#58;204&#8211;206&#46;</p>"
      ]
    ]
    "multimedia" => array:4 [
      0 => array:7 [
        "identificador" => "fig0005"
        "etiqueta" => "Figure 1"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr1.jpeg"
            "Alto" => 1064
            "Ancho" => 1501
            "Tamanyo" => 232346
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">A&#44; Necrotic pustules and papules on the trunk and lower extremities&#46; B&#44; Ulcers and extensive necrosis on the head&#46; C and D&#44; Large ulcers on the left forearm with exposed tendons and muscle&#46;</p>"
        ]
      ]
      1 => array:7 [
        "identificador" => "fig0010"
        "etiqueta" => "Figure 2"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr2.jpeg"
            "Alto" => 857
            "Ancho" => 1500
            "Tamanyo" => 189235
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">A&#44; PAS-stained smear showing cigar-shaped yeast cells &#40;original magnification &#215;100&#41;&#46; B&#44; Microscopic analysis of the culture showing sympodial conidia &#40;lactophenol blue&#44; original magnification &#215;40&#41;&#46; C&#44; Culture of <span class="elsevierStyleItalic">Sporothrix</span> species&#46;</p>"
        ]
      ]
      2 => array:7 [
        "identificador" => "fig0015"
        "etiqueta" => "Figure 3"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr3.jpeg"
            "Alto" => 840
            "Ancho" => 1500
            "Tamanyo" => 301557
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">A&#44; Histopathology of skin samples with suppurative granuloma containing lymphocytes&#44; epithelioid histiocytes&#44; and multinucleated giant cells &#40;hematoxylin-eosin&#44; original magnification &#215;5&#41;&#46; B&#44; Higher magnification image showing phagocytosed yeast cells &#40;hematoxylin-eosin&#44; original magnification &#215;40&#41;&#46; C&#44; Note the abundance of yeast cells &#40;PAS&#44; original magnification &#215;20&#41;&#46; D&#44; Ovoid and cigar-shaped yeast cells &#40;Gomori-Grocott&#44; original magnification &#215;20&#41;&#46;</p>"
        ]
      ]
      3 => array:7 [
        "identificador" => "fig0020"
        "etiqueta" => "Figure 4"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr4.jpeg"
            "Alto" => 805
            "Ancho" => 1500
            "Tamanyo" => 296530
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">Testicular biopsy&#46; A&#44; Substitution of the testicular parenchyma with chronic granulomatous inflammation with multinucleated giant cells&#44; areas of necrosis&#44; and polymorphonuclear infiltration &#40;hematoxylin-eosin&#44; original magnification &#215;5&#41;&#46; B&#44; Higher magnification image showing abundant ovoid yeast cells &#40;hematoxylin-eosin&#44; original magnification &#215;40&#41;&#46; C and D&#44; Spherical and cigar-shaped spores &#40;PAS and Gomori Grocott&#44; original magnification &#215;20&#41;&#46;</p>"
        ]
      ]
    ]
    "bibliografia" => array:2 [
      "titulo" => "References"
      "seccion" => array:1 [
        0 => array:2 [
          "identificador" => "bibs0005"
          "bibliografiaReferencia" => array:7 [
            0 => array:3 [
              "identificador" => "bib0005"
              "etiqueta" => "1"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Sporotrichosis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "R&#46; Arenas"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "LibroEditado" => array:5 [
                        "titulo" => "Microbiology and microbial infections"
                        "paginaInicial" => "367"
                        "paginaFinal" => "384"
                        "edicion" => "10th ed"
                        "serieFecha" => "2005"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            1 => array:3 [
              "identificador" => "bib0010"
              "etiqueta" => "2"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Esporotricosis&#58; prevalencia&#44; perfil cl&#237;nico y epidemiol&#243;gico en un centro de referencia en Colombia"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "G&#46; Rubio"
                            1 => "G&#46; S&#225;nchez"
                            2 => "L&#46; Porras"
                            3 => "Z&#46; Alvarado"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.riam.2010.01.001"
                      "Revista" => array:6 [
                        "tituloSerie" => "Rev Iberoam Micol"
                        "fecha" => "2010"
                        "volumen" => "27"
                        "paginaInicial" => "75"
                        "paginaFinal" => "79"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/20346295"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            2 => array:3 [
              "identificador" => "bib0015"
              "etiqueta" => "3"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Esporotricosis en la provincia de Sevilla &#40;Espa&#241;a&#41;"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "T&#46; Ojeda"
                            1 => "A&#46; Rodr&#237;guez-Pichardo"
                            2 => "A&#46;I&#46; Su&#225;rez"
                            3 => "F&#46;M&#46; Camacho"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.eimc.2010.06.011"
                      "Revista" => array:6 [
                        "tituloSerie" => "Enferm Infecc Microbiol Clin"
                        "fecha" => "2011"
                        "volumen" => "29"
                        "paginaInicial" => "233"
                        "paginaFinal" => "234"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/21330011"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            3 => array:3 [
              "identificador" => "bib0020"
              "etiqueta" => "4"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Sporothrix schenckii and sporotrichosis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "L&#46;M&#46; Lopes"
                            1 => "A&#46; Schubach"
                            2 => "R&#46;O&#46; Costa"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "An Acad Bras Cien"
                        "fecha" => "2006"
                        "volumen" => "78"
                        "paginaInicial" => "293"
                        "paginaFinal" => "308"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            4 => array:3 [
              "identificador" => "bib0025"
              "etiqueta" => "5"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Clasificaci&#243;n de la esporotricosis&#46; Una propuesta con base en el comportamiento inmunol&#243;gico"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "A&#46; Sa&#250;l"
                            1 => "A&#46; Bonifaz"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Dermatolog&#237;a Rev Mex"
                        "fecha" => "2011"
                        "volumen" => "55"
                        "paginaInicial" => "200"
                        "paginaFinal" => "208"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            5 => array:3 [
              "identificador" => "bib0030"
              "etiqueta" => "6"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Sporotrichosis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "E&#46; V&#225;zquez-del Mercado"
                            1 => "R&#46; Arenas"
                            2 => "C&#46; Padilla-Desgarenes"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.clindermatol.2011.09.017"
                      "Revista" => array:7 [
                        "tituloSerie" => "Clin Dermatol"
                        "fecha" => "2012"
                        "volumen" => "30"
                        "paginaInicial" => "437"
                        "paginaFinal" => "443"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/22682194"
                            "web" => "Medline"
                          ]
                        ]
                        "itemHostRev" => array:3 [
                          "pii" => "S1552526010000142"
                          "estado" => "S300"
                          "issn" => "15525260"
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            6 => array:3 [
              "identificador" => "bib0035"
              "etiqueta" => "7"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Clinical Practice Guidelines for the Management of Sporotrichosis&#58; 2007 Update by the Infectious Diseases Society of America"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "C&#46; Kauffman"
                            1 => "B&#46; Bustamante"
                            2 => "S&#46; Chapman"
                            3 => "E&#46; Pappas"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:4 [
                        "tituloSerie" => "CID"
                        "fecha" => "2007"
                        "paginaInicial" => "1255"
                        "paginaFinal" => "1265"
                      ]
                    ]
                  ]
                ]
              ]
            ]
          ]
        ]
      ]
    ]
    "agradecimientos" => array:1 [
      0 => array:4 [
        "identificador" => "xack75381"
        "titulo" => "Acknowledgements"
        "texto" => "<p id="par0075" class="elsevierStylePara elsevierViewall">We thank Dr&#46; Jos&#233; G&#46; Chanona Vilchis&#44; Head of the Department of Surgical Pathology of the Instituto Nacional de Cancerolog&#237;a&#44; for providing testicular biopsy samples and histological descriptions&#46;</p> <p id="par0080" class="elsevierStylePara elsevierViewall">We also thank Dr&#46; Diana Vilar Compte of the Infectious Diseases Service at the Hospital General Dr&#46; Manuel Gea Gonz&#225;lez for microbiological identification of superadded bacterial infections&#44; and Dr&#46; Horacio Vidrio Morgado&#44; Surgical Oncology Resident at the Instituto Nacional de Cancerolog&#237;a&#44; and Dr&#46; Alberto de los R&#237;os&#44; Internal Medicine Resident at the Hospital General Dr&#46; Manuel Gea Gonz&#225;lez&#44; for their role in the metabolic and surgical management of the patient&#46;</p>"
        "vista" => "all"
      ]
    ]
  ]
  "idiomaDefecto" => "en"
  "url" => "/15782190/0000010500000002/v1_201403090058/S1578219014000274/v1_201403090058/en/main.assets"
  "Apartado" => array:4 [
    "identificador" => "6157"
    "tipo" => "SECCION"
    "en" => array:2 [
      "titulo" => "Case and Research Letters"
      "idiomaDefecto" => true
    ]
    "idiomaDefecto" => "en"
  ]
  "PDF" => "https://static.elsevier.es/multimedia/15782190/0000010500000002/v1_201403090058/S1578219014000274/v1_201403090058/en/main.pdf?idApp=UINPBA000044&text.app=https://actasdermo.org/"
  "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1578219014000274?idApp=UINPBA000044"
]
Información del artículo
ISSN: 15782190
Idioma original: Inglés
Datos actualizados diariamente
año/Mes Html Pdf Total
2024 Noviembre 11 18 29
2024 Octubre 115 48 163
2024 Septiembre 110 27 137
2024 Agosto 110 73 183
2024 Julio 101 42 143
2024 Junio 112 55 167
2024 Mayo 128 54 182
2024 Abril 111 38 149
2024 Marzo 104 35 139
2024 Febrero 98 40 138
2024 Enero 108 37 145
2023 Diciembre 101 21 122
2023 Noviembre 105 31 136
2023 Octubre 94 27 121
2023 Septiembre 98 38 136
2023 Agosto 85 22 107
2023 Julio 116 35 151
2023 Junio 107 28 135
2023 Mayo 117 27 144
2023 Abril 116 31 147
2023 Marzo 128 38 166
2023 Febrero 81 19 100
2023 Enero 71 36 107
2022 Diciembre 78 56 134
2022 Noviembre 52 34 86
2022 Octubre 52 23 75
2022 Septiembre 53 46 99
2022 Agosto 51 33 84
2022 Julio 46 42 88
2022 Junio 47 42 89
2022 Mayo 109 29 138
2022 Abril 141 54 195
2022 Marzo 119 52 171
2022 Febrero 110 44 154
2022 Enero 118 43 161
2021 Diciembre 84 32 116
2021 Noviembre 83 62 145
2021 Octubre 99 59 158
2021 Septiembre 78 51 129
2021 Agosto 83 56 139
2021 Julio 66 40 106
2021 Junio 67 45 112
2021 Mayo 68 40 108
2021 Abril 163 73 236
2021 Marzo 67 31 98
2021 Febrero 69 31 100
2021 Enero 36 31 67
2020 Diciembre 29 27 56
2020 Noviembre 31 18 49
2020 Octubre 15 11 26
2020 Septiembre 21 20 41
2020 Agosto 24 13 37
2020 Julio 27 16 43
2020 Junio 24 21 45
2020 Mayo 27 23 50
2020 Abril 35 16 51
2020 Marzo 29 18 47
2020 Febrero 8 1 9
2020 Enero 0 4 4
2019 Diciembre 5 4 9
2019 Noviembre 4 0 4
2019 Octubre 0 3 3
2019 Septiembre 4 4 8
2019 Agosto 4 7 11
2019 Julio 8 13 21
2019 Junio 4 17 21
2019 Mayo 6 15 21
2019 Abril 2 20 22
2019 Marzo 1 6 7
2019 Febrero 7 6 13
2019 Enero 5 4 9
2018 Diciembre 0 4 4
2018 Noviembre 5 10 15
2018 Octubre 1 0 1
2018 Septiembre 4 0 4
2018 Marzo 8 0 8
2018 Febrero 71 2 73
2018 Enero 93 5 98
2017 Diciembre 98 6 104
2017 Noviembre 77 1 78
2017 Octubre 103 3 106
2017 Septiembre 55 11 66
2017 Agosto 93 5 98
2017 Julio 50 11 61
2017 Junio 80 7 87
2017 Mayo 50 5 55
2017 Abril 33 10 43
2017 Marzo 29 5 34
2017 Febrero 101 6 107
2017 Enero 39 10 49
2016 Diciembre 65 8 73
2016 Noviembre 75 12 87
2016 Octubre 116 7 123
2016 Septiembre 201 14 215
2016 Agosto 99 7 106
2016 Julio 44 5 49
2016 Junio 15 10 25
2016 Mayo 5 8 13
2016 Abril 3 5 8
2016 Marzo 4 2 6
2016 Febrero 19 2 21
2016 Enero 7 1 8
2015 Diciembre 11 10 21
2015 Noviembre 10 1 11
2015 Octubre 9 2 11
2015 Septiembre 6 4 10
2015 Agosto 3 3 6
2015 Julio 99 5 104
2015 Junio 48 9 57
2015 Mayo 71 11 82
2015 Abril 60 4 64
2015 Marzo 78 2 80
2015 Febrero 52 4 56
2015 Enero 39 6 45
2014 Diciembre 46 7 53
2014 Noviembre 48 5 53
2014 Octubre 41 6 47
2014 Septiembre 40 3 43
2014 Agosto 25 6 31
2014 Julio 32 6 38
2014 Junio 40 5 45
2014 Mayo 33 9 42
2014 Abril 19 9 28
2014 Marzo 8 6 14
Mostrar todo

Siga este enlace para acceder al texto completo del artículo

Idiomas
Actas Dermo-Sifiliográficas
es en

¿Es usted profesional sanitario apto para prescribir o dispensar medicamentos?

Are you a health professional able to prescribe or dispense drugs?