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    "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0065" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleItalic">To the Editor&#58;</span></p><p id="par0005" class="elsevierStylePara elsevierViewall">Lipodystrophy is a rare disease characterized by loss of adipose tissue that can be associated with metabolic disorders and autoimmune diseases&#44; primarily juvenile dermatomyositis&#46; Lipodystrophy in association with adult-onset dermatomyositis&#44; however&#44; is very rare&#46;</p><p id="par0010" class="elsevierStylePara elsevierViewall">A 23-year-old woman consulted for erythema and bilateral palpebral edema that had appeared 1 year earlier and skin lesions on the dorsum of the interphalangeal joints of both hands&#46; The patient reported that she had experienced muscle pain and weakness over the last 6 months&#44; as well as joint pain in her hands&#44; wrists&#44; elbows&#44; and knees&#46; She also mentioned a progressive loss of fat in the facial region and arms over the last 2 months&#46; The patient had no past history of interest and was not taking any medication&#46; She also reported no family history of connective tissue disease&#46;</p><p id="par0015" class="elsevierStylePara elsevierViewall">In the physical examination&#44; we observed a marked loss of adipose tissue in the face and arms&#59; the trunk and lower limbs were unaffected by this loss &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>&#41;&#46; There were atrophic erythematous lesions on the skin of the elbows and interphalangeal joints of the fingers &#40;<a class="elsevierStyleCrossRef" href="#fig0010">Fig&#46; 2</a>&#41;&#46; We also detected the presence of periorbital erythema and periungual telangiectasia &#40;<a class="elsevierStyleCrossRef" href="#fig0015">Fig&#46; 3</a>&#41;&#46; The patient had rigidity in the joints of the hands&#44; with no signs of arthritis&#44; and proximal muscle weakness &#40;grade 4-5 according to the Medical Research Council scale&#41;&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><elsevierMultimedia ident="fig0010"></elsevierMultimedia><elsevierMultimedia ident="fig0015"></elsevierMultimedia><p id="par0020" class="elsevierStylePara elsevierViewall">The blood tests showed normal levels of creatine kinase and aldolase&#46; The results of the antinuclear antibody test were positive&#44; with a titer of 1&#58;320 and a granular pattern&#46; The C3 and C4 fractions of the complement were within normal limits&#46; The anti-Jo1&#44; anti-Ro&#44; anti-La&#44; anti-nRNP&#44; anti-Sm&#44; anti-ssDNA and anti-dsDNA antibody test results were negative&#46; We detected no abnormalities in serum lipid or glucose levels&#46;</p><p id="par0025" class="elsevierStylePara elsevierViewall">Biopsy of the hand lesions showed lichenoid dermatitis with hydropic degeneration of the basement membrane and upper dermal edema&#46; There were no immunoglobulin &#40;Ig&#41; G&#44; IgA&#44; fibrinogen&#44; or complement deposits in the direct immunofluorescence assay&#46; An electrophysiological study showed no abnormalities&#46; We therefore performed a muscle biopsy&#44; which revealed muscle fiber necrosis and a lymphoplasmacytic inflammatory infiltrate&#46; Magnetic resonance imaging showed thickening of the perimuscular fascia of the arms&#44; shoulders&#44; buttocks&#44; and thighs&#46; Based on the above findings&#44; we arrived at the diagnosis of dermatomyositis&#46; Given this diagnosis in an adult&#44; we followed up with positron emission tomography&#44; which ruled out underlying neoplastic disease at the time of the visit and 2 years later&#46;</p><p id="par0030" class="elsevierStylePara elsevierViewall">Lipodystrophy is a rare disease characterized by the loss of subcutaneous adipose tissue&#46; It is classified as inherited or acquired and&#44; depending on its location&#44; as generalized&#44; partial &#40;relatively extensive but not generalized&#41;&#44; or localized&#46;<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a> When lipodystrophy is generalized or partial&#44; it is often associated with metabolic disorders&#44; such as insulin resistance and hypertriglyceridemia&#46;<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a></p><p id="par0035" class="elsevierStylePara elsevierViewall">Acquired lipodystrophy has been associated with infections&#44; antiretroviral therapy for the treatment of human immunodeficiency virus infection and with autoimmune diseases such as rheumatoid arthritis&#44; systemic lupus erythematosus&#44; Sj&#246;gren syndrome&#44; and dermatomyositis&#46;<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a> Dermatomyositis &#40;specifically&#44; juvenile dermatomyositis&#41; is the autoimmune disease most frequently related to the development of lipodystrophy&#46;<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a> The prevalence of lipodystrophy in juvenile dermatomyositis varies among studies from 10&#37; to 40&#37;&#46; In the only study performed with a large number of patients&#44; acquired lipodystrophy was observed in 8&#37; of patients with juvenile dermatomyositis&#44; while only 1 of the 692 adult patients with dermatomyositis had lipodystrophy&#46;<a class="elsevierStyleCrossRef" href="#bib0020"><span class="elsevierStyleSup">4</span></a> To date&#44; only 2 cases of lipodystrophy associated with adult-onset dermatomyositis have been published&#46;<a class="elsevierStyleCrossRefs" href="#bib0025"><span class="elsevierStyleSup">5&#44;6</span></a> The reasons for this lack of association are unknown&#46;</p><p id="par0040" class="elsevierStylePara elsevierViewall">One study has shown that a number of manifestations of dermatomyositis&#44; such as joint rigidity&#44; muscle atrophy&#44; panniculitis&#44; and calcinosis&#44; could be related to the development of lipodystrophy&#46;<a class="elsevierStyleCrossRef" href="#bib0020"><span class="elsevierStyleSup">4</span></a> Of all these signs&#44; our patient had only joint rigidity in the hands&#46;</p><p id="par0045" class="elsevierStylePara elsevierViewall">The etiology and pathogenesis of lipodystrophy associated with autoimmune disease remain unclear&#46; Patients with partial lipodystrophy often have low C3 levels&#44; which may trigger the alternative complement pathway and promote development of the disease&#46;<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a></p><p id="par0050" class="elsevierStylePara elsevierViewall">The majority of patients described in the literature developed lipodystrophy years after the onset of dermatomyositis&#44; as a late complication of severe&#44; chronic disease&#59; our patient&#44; however&#44; developed symptoms of dermatomyositis and lipodystrophy practically simultaneously&#46; In contrast to what occurs in most cases of partial lipodystrophy&#44; there were no metabolic abnormalities in our patient&#46; We were also unable to demonstrate etiologic or pathogenic mechanisms associated with immunologic abnormalities such as low levels of C3&#46; In agreement with reports from similar cases in the literature&#44;<a class="elsevierStyleCrossRefs" href="#bib0025"><span class="elsevierStyleSup">5&#44;6</span></a> treatment with oral prednisone and mycophenolate mofetil did not improve the facial lipoatrophy in our patient&#46;</p><p id="par0055" class="elsevierStylePara elsevierViewall">We have presented a very rare case of adult lipoatrophy simultaneously associated with dermatomyositis&#46;</p><p id="par0060" class="elsevierStylePara elsevierViewall">Based on published data&#44; it would be prudent to closely monitor all patients with dermatomyositis who develop a loss of subcutaneous fat in order to progressively rule out abnormalities in the metabolism of lipids and carbohydrates&#46;</p></span>"
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Case and Research Letter
Adult Dermatomyositis Associated With Lipodystrophy
Dermatomiositis del adulto asociada a lipodistrofia
M. Pretel
Autor para correspondencia
mpretel@unav.es

Corresponding author.
, M. Navedo, L. Marqués, L. Aguado
Departamento de Dermatología, Clínica Universidad de Navarra, Pamplona, Navarra, Spain
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          "en" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Atrophic erythematous lesions in the interphalangeal joints of the fingers&#46;</p>"
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    "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0065" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleItalic">To the Editor&#58;</span></p><p id="par0005" class="elsevierStylePara elsevierViewall">Lipodystrophy is a rare disease characterized by loss of adipose tissue that can be associated with metabolic disorders and autoimmune diseases&#44; primarily juvenile dermatomyositis&#46; Lipodystrophy in association with adult-onset dermatomyositis&#44; however&#44; is very rare&#46;</p><p id="par0010" class="elsevierStylePara elsevierViewall">A 23-year-old woman consulted for erythema and bilateral palpebral edema that had appeared 1 year earlier and skin lesions on the dorsum of the interphalangeal joints of both hands&#46; The patient reported that she had experienced muscle pain and weakness over the last 6 months&#44; as well as joint pain in her hands&#44; wrists&#44; elbows&#44; and knees&#46; She also mentioned a progressive loss of fat in the facial region and arms over the last 2 months&#46; The patient had no past history of interest and was not taking any medication&#46; She also reported no family history of connective tissue disease&#46;</p><p id="par0015" class="elsevierStylePara elsevierViewall">In the physical examination&#44; we observed a marked loss of adipose tissue in the face and arms&#59; the trunk and lower limbs were unaffected by this loss &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>&#41;&#46; There were atrophic erythematous lesions on the skin of the elbows and interphalangeal joints of the fingers &#40;<a class="elsevierStyleCrossRef" href="#fig0010">Fig&#46; 2</a>&#41;&#46; We also detected the presence of periorbital erythema and periungual telangiectasia &#40;<a class="elsevierStyleCrossRef" href="#fig0015">Fig&#46; 3</a>&#41;&#46; The patient had rigidity in the joints of the hands&#44; with no signs of arthritis&#44; and proximal muscle weakness &#40;grade 4-5 according to the Medical Research Council scale&#41;&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><elsevierMultimedia ident="fig0010"></elsevierMultimedia><elsevierMultimedia ident="fig0015"></elsevierMultimedia><p id="par0020" class="elsevierStylePara elsevierViewall">The blood tests showed normal levels of creatine kinase and aldolase&#46; The results of the antinuclear antibody test were positive&#44; with a titer of 1&#58;320 and a granular pattern&#46; The C3 and C4 fractions of the complement were within normal limits&#46; The anti-Jo1&#44; anti-Ro&#44; anti-La&#44; anti-nRNP&#44; anti-Sm&#44; anti-ssDNA and anti-dsDNA antibody test results were negative&#46; We detected no abnormalities in serum lipid or glucose levels&#46;</p><p id="par0025" class="elsevierStylePara elsevierViewall">Biopsy of the hand lesions showed lichenoid dermatitis with hydropic degeneration of the basement membrane and upper dermal edema&#46; There were no immunoglobulin &#40;Ig&#41; G&#44; IgA&#44; fibrinogen&#44; or complement deposits in the direct immunofluorescence assay&#46; An electrophysiological study showed no abnormalities&#46; We therefore performed a muscle biopsy&#44; which revealed muscle fiber necrosis and a lymphoplasmacytic inflammatory infiltrate&#46; Magnetic resonance imaging showed thickening of the perimuscular fascia of the arms&#44; shoulders&#44; buttocks&#44; and thighs&#46; Based on the above findings&#44; we arrived at the diagnosis of dermatomyositis&#46; Given this diagnosis in an adult&#44; we followed up with positron emission tomography&#44; which ruled out underlying neoplastic disease at the time of the visit and 2 years later&#46;</p><p id="par0030" class="elsevierStylePara elsevierViewall">Lipodystrophy is a rare disease characterized by the loss of subcutaneous adipose tissue&#46; It is classified as inherited or acquired and&#44; depending on its location&#44; as generalized&#44; partial &#40;relatively extensive but not generalized&#41;&#44; or localized&#46;<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a> When lipodystrophy is generalized or partial&#44; it is often associated with metabolic disorders&#44; such as insulin resistance and hypertriglyceridemia&#46;<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a></p><p id="par0035" class="elsevierStylePara elsevierViewall">Acquired lipodystrophy has been associated with infections&#44; antiretroviral therapy for the treatment of human immunodeficiency virus infection and with autoimmune diseases such as rheumatoid arthritis&#44; systemic lupus erythematosus&#44; Sj&#246;gren syndrome&#44; and dermatomyositis&#46;<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a> Dermatomyositis &#40;specifically&#44; juvenile dermatomyositis&#41; is the autoimmune disease most frequently related to the development of lipodystrophy&#46;<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a> The prevalence of lipodystrophy in juvenile dermatomyositis varies among studies from 10&#37; to 40&#37;&#46; In the only study performed with a large number of patients&#44; acquired lipodystrophy was observed in 8&#37; of patients with juvenile dermatomyositis&#44; while only 1 of the 692 adult patients with dermatomyositis had lipodystrophy&#46;<a class="elsevierStyleCrossRef" href="#bib0020"><span class="elsevierStyleSup">4</span></a> To date&#44; only 2 cases of lipodystrophy associated with adult-onset dermatomyositis have been published&#46;<a class="elsevierStyleCrossRefs" href="#bib0025"><span class="elsevierStyleSup">5&#44;6</span></a> The reasons for this lack of association are unknown&#46;</p><p id="par0040" class="elsevierStylePara elsevierViewall">One study has shown that a number of manifestations of dermatomyositis&#44; such as joint rigidity&#44; muscle atrophy&#44; panniculitis&#44; and calcinosis&#44; could be related to the development of lipodystrophy&#46;<a class="elsevierStyleCrossRef" href="#bib0020"><span class="elsevierStyleSup">4</span></a> Of all these signs&#44; our patient had only joint rigidity in the hands&#46;</p><p id="par0045" class="elsevierStylePara elsevierViewall">The etiology and pathogenesis of lipodystrophy associated with autoimmune disease remain unclear&#46; Patients with partial lipodystrophy often have low C3 levels&#44; which may trigger the alternative complement pathway and promote development of the disease&#46;<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a></p><p id="par0050" class="elsevierStylePara elsevierViewall">The majority of patients described in the literature developed lipodystrophy years after the onset of dermatomyositis&#44; as a late complication of severe&#44; chronic disease&#59; our patient&#44; however&#44; developed symptoms of dermatomyositis and lipodystrophy practically simultaneously&#46; In contrast to what occurs in most cases of partial lipodystrophy&#44; there were no metabolic abnormalities in our patient&#46; We were also unable to demonstrate etiologic or pathogenic mechanisms associated with immunologic abnormalities such as low levels of C3&#46; In agreement with reports from similar cases in the literature&#44;<a class="elsevierStyleCrossRefs" href="#bib0025"><span class="elsevierStyleSup">5&#44;6</span></a> treatment with oral prednisone and mycophenolate mofetil did not improve the facial lipoatrophy in our patient&#46;</p><p id="par0055" class="elsevierStylePara elsevierViewall">We have presented a very rare case of adult lipoatrophy simultaneously associated with dermatomyositis&#46;</p><p id="par0060" class="elsevierStylePara elsevierViewall">Based on published data&#44; it would be prudent to closely monitor all patients with dermatomyositis who develop a loss of subcutaneous fat in order to progressively rule out abnormalities in the metabolism of lipids and carbohydrates&#46;</p></span>"
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        "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Please cite this article as&#58; Pretel M&#44; et al&#46; Dermatomiositis del adulto asociada a lipodistrofia&#46; Actas Dermosifiliogr&#46; 2013&#59;104&#58;724&#8211;5&#46;</p>"
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