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partially exophytic erythematous plaque of 1&#46;5<span class="elsevierStyleHsp" style=""></span>cm in diameter that had developed on the right lower eyelid and affected the free border &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>A&#41;&#46; Biopsy showed the lesion to be an actinic keratosis &#40;<a class="elsevierStyleCrossRef" href="#fig0010">Fig&#46; 2</a>A&#41;&#46; Photodynamic therapy &#40;PDT&#41; was chosen for treatment in accordance with the recommended protocol for the treatment of basal cell carcinoma&#46;<a class="elsevierStyleCrossRefs" href="#bib0015"><span class="elsevierStyleSup">3&#44;4</span></a> Topical methyl 5-aminolevulinate cream &#40;Metvix&#41; was applied to the lesion&#46; The cream was removed after 3<span class="elsevierStyleHsp" style=""></span>hours and uptake by the lesion was confirmed with the aid of a Wood lamp&#46; A sterile&#44; opaque black plastic shield was used to protect the eye&#59; topical anesthetic eye drops &#40;0&#46;1&#37; tetracaine hydrochloride plus 0&#46;4&#37; oxybuprocaine hydrochloride&#41; should be instilled into the eye 5<span class="elsevierStyleHsp" style=""></span>minutes before inserting the shield&#44; and a viscoelastic substance such as Gonioftal gel &#40;latex-free hydroxyethylcellulose&#41; should be used to minimize contact with the surface of the eye&#46; The lesion was infiltrated with local anesthetic &#40;1&#37; mepivacaine&#41; and then illuminated using a light-emitting diode lamp with a wavelength of 634<span class="elsevierStyleHsp" style=""></span>nm &#40;Aktilite&#59; PhotoCure&#44; Galderma&#41;&#44; administering 37<span class="elsevierStyleHsp" style=""></span>J&#47;cm<span class="elsevierStyleSup">2</span> over a period of 8<span class="elsevierStyleHsp" style=""></span>minutes at a distance of 10<span class="elsevierStyleHsp" style=""></span>cm&#46; The patient&#39;s sensation of burning was reduced by the application of fine sprays of thermal water or liquid nitrogen from a distance&#46; After completing the treatment session&#44; we removed the shield by pulling down on the lower eyelid&#44; thus minimizing the risk of corneal injury&#44; and the patient was prescribed chloramphenicol eye drops for administration every 8<span class="elsevierStyleHsp" style=""></span>hours for the first 3 days&#46; A second treatment session was performed 2 weeks later&#46; The therapy was well tolerated and in the treated area there was only mild erythema and edema&#44; which resolved within a few days&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><elsevierMultimedia ident="fig0010"></elsevierMultimedia><p id="par0015" class="elsevierStylePara elsevierViewall">There was a marked reduction in the size of the lesion&#46; Subsequent treatment with imiquimod 5&#37; cream 3 times a week for 4 weeks produced no inflammation or improvement&#44; and curettage biopsy was therefore performed for histological study&#44; with electrocoagulation of the residual lesion &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>B&#41;&#46; The biopsy revealed only seborrheic keratosis &#40;<a class="elsevierStyleCrossRef" href="#fig0010">Fig&#46; 2</a>B&#41;&#46;</p><p id="par0020" class="elsevierStylePara elsevierViewall">The incidence of actinic keratosis on the eyelids has increased in the last 2 decades&#46; PDT has been shown to be effective in the treatment of basal cell carcinoma&#44; actinic keratosis&#44; and Bowen disease&#46; A recently published case series described the effectiveness of PDT for patients with tumors on the eyelids&#46;<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a> The authors of that report recommended initial curettage of the lesion&#44; the use of topical methyl 5-aminolevulinate&#44; and repetition of the treatment after a week&#46; PDT offers better cosmetic and functional results and is associated with a lower morbidity and cost than surgery&#46;<a class="elsevierStyleCrossRef" href="#bib0025"><span class="elsevierStyleSup">5</span></a> One of the important limitations of this treatment is the risk of phototoxic eye damage and the need for follow-up due to the long-term risk of recurrence&#46;</p><p id="par0025" class="elsevierStylePara elsevierViewall">Another effective therapeutic option in selected cases is topical imiquimod 5&#37; cream&#46; Its application 5 times a week for 6 weeks has been shown to be effective in the treatment of periocular tumors&#46;<a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">6</span></a> However&#44; its use is controversial in tumors situated at less than 5<span class="elsevierStyleHsp" style=""></span>mm from the free border of the eyelid because of the possibility of local adverse effects&#46;</p><p id="par0030" class="elsevierStylePara elsevierViewall">Our patient presented a satisfactory clinical course after PDT&#44; with only a residual seborrheic keratosis that remained present after treatment&#46; In conclusion&#44; we must insist that tumors in the area of the eyelids are a therapeutic challenge for the dermatologist&#46; Surgery continues to be the treatment of choice for tumors situated in areas difficult to treat&#44; but PDT is an effective&#44; noninvasive therapeutic alternative that is well tolerated by the patient and that offers good cosmetic and functional results&#44; 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Case and Research Letter
Photodynamic Therapy as a Response to the Challenge of Treating Actinic Keratosis in the Eyelid Area
Terapia fotodinámica como respuesta al reto de tratar una queratosis actínica en el área palpebral
F. Toledo- Alberola
Autor para correspondencia
ftoledo@coma.es

Corresponding author.
, I. Belinchón-Romero, J. Guijarro-Llorca, P. Albares-Tendero
Servicio de Dermatología, Hospital General Universitario de Alicante, Alicante, Spain
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    "titulo" => "Photodynamic Therapy as a Response to the Challenge of Treating Actinic Keratosis in the Eyelid Area"
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        "titulo" => "Terapia fotodin&#225;mica como respuesta al reto de tratar una queratosis act&#237;nica en el &#225;rea palpebral"
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          "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">A&#44; Clinical image before treatment&#44; showing the presence of a tumor on the free border of the lower right eyelid&#46; B&#44; Final result at 6 months&#44; after 2 sessions of photodynamic therapy and curettage of the residual lesion&#46;</p>"
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    "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">Around 90&#37; of nonmelanoma skin cancers arise on the head and neck and about 10&#37; of these occur in the area of the eyelids&#46;<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a> Surgery continues to be the treatment of choice&#44;<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a> but concerns about the risk of postoperative complications&#44; local recurrence&#44; or a poor cosmetic and functional outcome have led to the investigation of alternative options&#44; such as cryotherapy&#44; radiation therapy&#44; chemotherapy&#44; retinoids&#44; topical immunomodulators&#44; and photodynamic therapy &#40;PDT&#41;&#46; The choice of treatment will depend on the age of the patient&#44; the site and size of the tumor&#44; and the experience of the dermatologist&#46;</p><p id="par0010" class="elsevierStylePara elsevierViewall">We present the case of an 82-year-old man who was seen for a desquamating&#44; partially exophytic erythematous plaque of 1&#46;5<span class="elsevierStyleHsp" style=""></span>cm in diameter that had developed on the right lower eyelid and affected the free border &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>A&#41;&#46; Biopsy showed the lesion to be an actinic keratosis &#40;<a class="elsevierStyleCrossRef" href="#fig0010">Fig&#46; 2</a>A&#41;&#46; Photodynamic therapy &#40;PDT&#41; was chosen for treatment in accordance with the recommended protocol for the treatment of basal cell carcinoma&#46;<a class="elsevierStyleCrossRefs" href="#bib0015"><span class="elsevierStyleSup">3&#44;4</span></a> Topical methyl 5-aminolevulinate cream &#40;Metvix&#41; was applied to the lesion&#46; The cream was removed after 3<span class="elsevierStyleHsp" style=""></span>hours and uptake by the lesion was confirmed with the aid of a Wood lamp&#46; A sterile&#44; opaque black plastic shield was used to protect the eye&#59; topical anesthetic eye drops &#40;0&#46;1&#37; tetracaine hydrochloride plus 0&#46;4&#37; oxybuprocaine hydrochloride&#41; should be instilled into the eye 5<span class="elsevierStyleHsp" style=""></span>minutes before inserting the shield&#44; and a viscoelastic substance such as Gonioftal gel &#40;latex-free hydroxyethylcellulose&#41; should be used to minimize contact with the surface of the eye&#46; The lesion was infiltrated with local anesthetic &#40;1&#37; mepivacaine&#41; and then illuminated using a light-emitting diode lamp with a wavelength of 634<span class="elsevierStyleHsp" style=""></span>nm &#40;Aktilite&#59; PhotoCure&#44; Galderma&#41;&#44; administering 37<span class="elsevierStyleHsp" style=""></span>J&#47;cm<span class="elsevierStyleSup">2</span> over a period of 8<span class="elsevierStyleHsp" style=""></span>minutes at a distance of 10<span class="elsevierStyleHsp" style=""></span>cm&#46; The patient&#39;s sensation of burning was reduced by the application of fine sprays of thermal water or liquid nitrogen from a distance&#46; After completing the treatment session&#44; we removed the shield by pulling down on the lower eyelid&#44; thus minimizing the risk of corneal injury&#44; and the patient was prescribed chloramphenicol eye drops for administration every 8<span class="elsevierStyleHsp" style=""></span>hours for the first 3 days&#46; A second treatment session was performed 2 weeks later&#46; The therapy was well tolerated and in the treated area there was only mild erythema and edema&#44; which resolved within a few days&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><elsevierMultimedia ident="fig0010"></elsevierMultimedia><p id="par0015" class="elsevierStylePara elsevierViewall">There was a marked reduction in the size of the lesion&#46; Subsequent treatment with imiquimod 5&#37; cream 3 times a week for 4 weeks produced no inflammation or improvement&#44; and curettage biopsy was therefore performed for histological study&#44; with electrocoagulation of the residual lesion &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>B&#41;&#46; The biopsy revealed only seborrheic keratosis &#40;<a class="elsevierStyleCrossRef" href="#fig0010">Fig&#46; 2</a>B&#41;&#46;</p><p id="par0020" class="elsevierStylePara elsevierViewall">The incidence of actinic keratosis on the eyelids has increased in the last 2 decades&#46; PDT has been shown to be effective in the treatment of basal cell carcinoma&#44; actinic keratosis&#44; and Bowen disease&#46; A recently published case series described the effectiveness of PDT for patients with tumors on the eyelids&#46;<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a> The authors of that report recommended initial curettage of the lesion&#44; the use of topical methyl 5-aminolevulinate&#44; and repetition of the treatment after a week&#46; PDT offers better cosmetic and functional results and is associated with a lower morbidity and cost than surgery&#46;<a class="elsevierStyleCrossRef" href="#bib0025"><span class="elsevierStyleSup">5</span></a> One of the important limitations of this treatment is the risk of phototoxic eye damage and the need for follow-up due to the long-term risk of recurrence&#46;</p><p id="par0025" class="elsevierStylePara elsevierViewall">Another effective therapeutic option in selected cases is topical imiquimod 5&#37; cream&#46; Its application 5 times a week for 6 weeks has been shown to be effective in the treatment of periocular tumors&#46;<a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">6</span></a> However&#44; its use is controversial in tumors situated at less than 5<span class="elsevierStyleHsp" style=""></span>mm from the free border of the eyelid because of the possibility of local adverse effects&#46;</p><p id="par0030" class="elsevierStylePara elsevierViewall">Our patient presented a satisfactory clinical course after PDT&#44; with only a residual seborrheic keratosis that remained present after treatment&#46; In conclusion&#44; we must insist that tumors in the area of the eyelids are a therapeutic challenge for the dermatologist&#46; Surgery continues to be the treatment of choice for tumors situated in areas difficult to treat&#44; but PDT is an effective&#44; noninvasive therapeutic alternative that is well tolerated by the patient and that offers good cosmetic and functional results&#44; as we have shown with the case presented&#46;</p></span>"
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Información del artículo
ISSN: 15782190
Idioma original: Inglés
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2014 Mayo 30 10 40
2014 Abril 14 3 17
2014 Marzo 8 2 10
2014 Febrero 11 5 16
2014 Enero 10 3 13
2013 Diciembre 21 5 26
2013 Noviembre 13 6 19
2013 Octubre 13 0 13
2013 Septiembre 7 5 12
2013 Agosto 9 7 16
2013 Julio 6 6 12
2013 Junio 6 10 16
2013 Mayo 5 8 13
2013 Abril 15 9 24
2013 Marzo 14 5 19
2013 Febrero 25 6 31
2013 Enero 41 6 47
2012 Diciembre 29 8 37
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Idiomas
Actas Dermo-Sifiliográficas
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¿Es usted profesional sanitario apto para prescribir o dispensar medicamentos?

Are you a health professional able to prescribe or dispense drugs?