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The HS improved with the first infusion of the drug&#44; but after 10 months of treatment the patient developed well-defined&#44; scaly&#44; erythematous lesions in the groin&#44; axillas&#44; and intergluteal and inframammary regions &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>&#41;&#46; Direct microscopy with potassium hydroxide and culture were negative for fungi&#46; Histology showed an epidermis with regular acanthosis&#44; hyperkeratosis with parakeratosis&#44; and suprapapillary thinning&#44; confirming the diagnosis of flexural or inverted psoriasis &#40;<a class="elsevierStyleCrossRef" href="#fig0010">Fig&#46; 2</a>&#41;&#46; At the time of writing&#44; the patient was receiving intermittent treatment with topical hydrocortisone 2&#46;5&#37;&#44; which enabled her to keep the psoriasis under control&#46; She continued the treatment with infliximab and the clinical course of the HS was favourable&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><elsevierMultimedia ident="fig0010"></elsevierMultimedia><p id="par0020" class="elsevierStylePara elsevierViewall">The therapeutic management of HS is a challenge for the dermatologist&#46; Several treatments have shown mixed results and none of them has been fully effective&#46; Local treatments include antiseptic washes&#44; topical antibiotics&#44; and intralesional corticosteroid injections&#46; Systemic treatments include oral retinoids&#44; antibiotics such as minocycline or combined clindamycin and rifampicin&#44; contraceptives alone or in combination with an antiandrogen&#44; cycles of oral corticosteroids&#44; and sulfone&#46; Surgery&#44; laser hair removal&#44; photodynamic therapy&#44; and even radiation therapy have also shown some efficacy&#46;<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a></p><p id="par0025" class="elsevierStylePara elsevierViewall">Recently&#44; anti-TNF-&#945; agents have shown good results in moderate to severe HS that is poorly controlled by conventional treatments&#46;<a class="elsevierStyleCrossRefs" href="#bib0010"><span class="elsevierStyleSup">2&#8211;4</span></a> These drugs are used for inflammatory diseases in which TNF-&#945; is involved&#44; such as inflammatory bowel disease&#44; rheumatoid arthritis&#44; ankylosing spondylitis&#44; and psoriasis&#46; Inflammatory bowel disease has been associated with an increased risk of developing HS&#46;<a class="elsevierStyleCrossRef" href="#bib0045"><span class="elsevierStyleSup">9</span></a> Moreover&#44; the risk of developing psoriasis is of 6&#37; to 11&#37; in patients with inflammatory bowel disease&#44; a higher risk than in the general population&#46;<a class="elsevierStyleCrossRefs" href="#bib0025"><span class="elsevierStyleSup">5&#44;6</span></a> Smoking&#44; treatment with lithium salts&#44; and obesity are aggravating factors for both HS and psoriasis&#46;<a class="elsevierStyleCrossRefs" href="#bib0005"><span class="elsevierStyleSup">1&#44;9</span></a> In addition&#44; TNF-&#945; has been implicated in the pathophysiology of both diseases&#46; Elevated levels of TNF-&#945;&#44; IL-10&#44; and IL-1&#946; have recently been reported in patients with HS&#44; which would explain the good response to these drugs<a class="elsevierStyleCrossRef" href="#bib0050"><span class="elsevierStyleSup">10</span></a>&#59; however&#44; not all patients with HS respond to anti-TNF-&#945; agents and most do so only partially&#46;<a class="elsevierStyleCrossRefs" href="#bib0010"><span class="elsevierStyleSup">2&#8211;4</span></a> Furthermore&#44; HS lesions are often superinfected by microorganisms and there is a theoretical risk of dissemination of the infection with anti-TNF-&#945; agents&#46;</p><p id="par0030" class="elsevierStylePara elsevierViewall">Though anti-TNF-&#945; agents are indicated for the treatment of moderate and severe forms of psoriasis&#44; the possibility of paradoxical phenomena&#44; such as the onset or exacerbation of psoriasis&#44; is recognized with all of them &#40;infliximab&#44; etanercept&#44; and adalimumab&#41;&#46;<a class="elsevierStyleCrossRefs" href="#bib0025"><span class="elsevierStyleSup">5&#8211;8</span></a> Outbreaks of psoriasis associated with this drug usually appear as palmoplantar&#44; pustular&#44; or plaque-type psoriasis and more rarely as inverse psoriasis&#44; as in our patient&#46;<a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">6</span></a> The time of onset varies from 4 months to several years after the start of treatment&#46;<a class="elsevierStyleCrossRefs" href="#bib0035"><span class="elsevierStyleSup">7&#44;8</span></a> Depending on the severity of the psoriasis symptoms&#44; the anti-TNF-&#945; agent can be maintained or replaced by another immunosuppressant&#46; In 85&#37; of cases&#44; the change to another anti-TNF-&#945; agent does not solve the occurrence of psoriasis&#44; which is therefore considered a class effect&#46;<a class="elsevierStyleCrossRef" href="#bib0040"><span class="elsevierStyleSup">8</span></a> The mechanism by which psoriasis occurs in patients treated with anti-TNF-&#945; agents is unknown&#46; It has been suggested that the decreased TNF-&#945; causes an increase in interferon &#945;&#44; which in some patients leads to the development and worsening of psoriasis lesions&#44; but further studies are needed to confirm this hypothesis&#46;<a class="elsevierStyleCrossRefs" href="#bib0040"><span class="elsevierStyleSup">8&#44;10</span></a> By contrast&#44; interferon &#945; levels are decreased in HS&#46;<a class="elsevierStyleCrossRef" href="#bib0050"><span class="elsevierStyleSup">10</span></a> This finding would explain the good response of HS to treatment with infliximab and the onset of psoriasis in our patient&#46;</p><p id="par0035" class="elsevierStylePara elsevierViewall">We stress the importance of this case because it is the first published case of the appearance of psoriasis in a patient with HS treated with an anti-TNF-&#945; agent &#40;infliximab&#41;&#44; because it had an atypical presentation as flexural or inverse psoriasis&#44; and because it showed a good response to treatment with only topical corticosteroids&#44; without the need to interrupt the infliximab prescribed to treat the underlying disease&#46;</p><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">Conflicts of Interests</span><p id="par0040" class="elsevierStylePara elsevierViewall">Drs&#46; Almudena Gonz&#225;lez and Carlos Nu&#241;o-Ricotti declare that they have no conflicts of interest&#46;</p><p id="par0045" class="elsevierStylePara elsevierViewall">Dr&#46; Luis Dehesa has participated in conferences for Abbott&#44; Pfizer&#44; and Astellas&#46;</p><p id="par0050" class="elsevierStylePara elsevierViewall">Dr&#46; Francisco Kerdel has participated in conferences and studies for Amgen&#44; Abbott&#44; Jansen&#44; Schering-Plough&#44; Pfizer&#44; and Eisai&#46;</p></span></span>"
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                    0 => array:2 [
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                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
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                            4 => "F&#46;A&#46; Kerdel"
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                  ]
                ]
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              "etiqueta" => "3"
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                0 => array:2 [
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                    0 => array:2 [
                      "titulo" => "Hidrosadenitis supurativa&#46; Respuesta al tratamiento con infliximab"
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                          "autores" => array:6 [
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                            3 => "R&#46; Goiriz-Vald&#233;s"
                            4 => "P&#46; Fern&#225;ndez-Pe&#241;as"
                            5 => "A&#46; Garc&#237;a-D&#237;ez"
                          ]
                        ]
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                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
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                        "paginaInicial" => "325"
                        "paginaFinal" => "331"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17555675"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            3 => array:3 [
              "identificador" => "bib0020"
              "etiqueta" => "4"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "A double-blind placebo-controlled randomized trial of adalimumab in the treatment of hidradenitis suppurativa"
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                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
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                            1 => "C&#46;D&#46; Lynggaard"
                            2 => "S&#46; Lophaven"
                            3 => "C&#46; Zachariae"
                            4 => "D&#46;N&#46; Dufour"
                            5 => "G&#46;B&#46; Jemec"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1111/j.1365-2133.2011.10339.x"
                      "Revista" => array:6 [
                        "tituloSerie" => "Br J Dermatol"
                        "fecha" => "2011"
                        "volumen" => "165"
                        "paginaInicial" => "391"
                        "paginaFinal" => "398"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/21457202"
                            "web" => "Medline"
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                    ]
                  ]
                ]
              ]
            ]
            4 => array:3 [
              "identificador" => "bib0025"
              "etiqueta" => "5"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Psoriasiform and pustular eruption induced by infliximab"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "H&#46; Takahashi"
                            1 => "Y&#46; Hashimoto"
                            2 => "A&#46; Ishida-Yamamoto"
                            3 => "T&#46; Ashida"
                            4 => "Y&#46; Kohgo"
                            5 => "H&#46; Iizuka"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1111/j.1346-8138.2007.00312.x"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Dermatol"
                        "fecha" => "2007"
                        "volumen" => "34"
                        "paginaInicial" => "468"
                        "paginaFinal" => "472"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17584325"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            5 => array:3 [
              "identificador" => "bib0030"
              "etiqueta" => "6"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Flexural psoriasis induced by infliximab and adalimumab in a patient with Crohn&#39;s disease"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "A&#46; Avila Alvarez"
                            1 => "L&#46; Garc&#237;a-Alonso"
                            2 => "A&#46; Solar Boga"
                            3 => "J&#46; Garc&#237;a-Silva"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "An Pediatr &#40;Barc&#41;"
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                        "volumen" => "70"
                        "paginaInicial" => "278"
                        "paginaFinal" => "281"
                      ]
                    ]
                  ]
                ]
              ]
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              "etiqueta" => "7"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Tumor necrosis factor-alpha inhibitor-induced psoriasis or psoriasiform exanthemata&#58; first 120 cases from the literature including a series of six new patients"
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                        0 => array:2 [
                          "etal" => false
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                            2 => "A&#46; Koch"
                            3 => "J&#46; Sch&#246;nlebe"
                            4 => "E&#46; K&#246;stler"
                            5 => "G&#46; Haroske"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Am J Clin Dermatol"
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                        "paginaInicial" => "1"
                        "paginaFinal" => "14"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18092839"
                            "web" => "Medline"
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                      ]
                    ]
                  ]
                ]
              ]
            ]
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              "etiqueta" => "8"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Induction and exacerbation of psoriasis with TNF-blockade therapy&#58; a review and analysis of 127 cases"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
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                            1 => "A&#46;B&#46; Gottlieb"
                            2 => "J&#46;F&#46; Kerbleski"
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                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1080/09546630802441234"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Dermatolog Treat"
                        "fecha" => "2009"
                        "volumen" => "20"
                        "paginaInicial" => "100"
                        "paginaFinal" => "108"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18923992"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
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              "etiqueta" => "9"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Hidradenitis suppurativa and Crohn&#39;s disease&#58; two cases that support an association"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "S&#46; Yazdanyar"
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                            2 => "G&#46;B&#46; Jemec"
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                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
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                      "Revista" => array:6 [
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                        "volumen" => "19"
                        "paginaInicial" => "23"
                        "paginaFinal" => "25"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/21390477"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
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              "etiqueta" => "10"
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                0 => array:2 [
                  "contribucion" => array:1 [
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                      "titulo" => "Elevated levels of tumour necrosis factor &#40;TNF&#41;-&#945;&#44; interleukin &#40;IL&#41;-1&#946; and IL-10 in hidradenitis suppurativa skin&#58; a rationale for targeting TNF-&#945; and IL-1&#946;"
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                            3 => "W&#46;A&#46; Dik"
                            4 => "J&#46;D&#46; Laman"
                            5 => "E&#46;P&#46; Prens"
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                    ]
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                        "link" => array:1 [
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Case and research letter
Flexural or Inverse Psoriasis in a Patient With Hidradenitis Suppurativa Receiving Treatment With Infliximab
Aparición de psoriasis flexural o invertida en una paciente con hidrosadenitis supurativa en tratamiento con infliximab
A. Nuño-Gonzáleza,
Autor para correspondencia
almudenanuno@hotmail.com

Corresponding author.
, L. Dehesab, C. Ricottib, F. Kerdelb
a Unidad de Dermatología, Hospital Universitario Fundación Alcorcón, Madrid, Spain
b Florida Academic Dermatology Center, University of Miami Hospital, Florida, USA
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agents&#44;<a class="elsevierStyleCrossRefs" href="#bib0025"><span class="elsevierStyleSup">5&#8211;8</span></a> to our knowledge this disease has not yet been described in patients with HS treated with these drugs&#46;</p><p id="par0015" class="elsevierStylePara elsevierViewall">We report the case of a 50-year-old&#44; obese&#44; non-smoking woman with no relevant past history except for HS diagnosed at the age of 20 and that had worsened over the previous 3 years&#46; She had received several treatments&#58; daily antiseptic washes&#44; topical clindamycin and mupirocin&#44; several 6-month courses of minocycline 100<span class="elsevierStyleHsp" style=""></span>mg per day&#44; and a 3-month course of daily clindamycin 300<span class="elsevierStyleHsp" style=""></span>mg plus rifampicin 300 <span class="elsevierStyleHsp" style=""></span>mg&#46; The response to all these treatments had been poor&#44; so the patient was included in a clinical trial for treatment of HS with infliximab<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a> and began treatment at a dose of 5<span class="elsevierStyleHsp" style=""></span>mg&#47;kg every 8 weeks&#46; The HS improved with the first infusion of the drug&#44; but after 10 months of treatment the patient developed well-defined&#44; scaly&#44; erythematous lesions in the groin&#44; axillas&#44; and intergluteal and inframammary regions &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>&#41;&#46; Direct microscopy with potassium hydroxide and culture were negative for fungi&#46; Histology showed an epidermis with regular acanthosis&#44; hyperkeratosis with parakeratosis&#44; and suprapapillary thinning&#44; confirming the diagnosis of flexural or inverted psoriasis &#40;<a class="elsevierStyleCrossRef" href="#fig0010">Fig&#46; 2</a>&#41;&#46; At the time of writing&#44; the patient was receiving intermittent treatment with topical hydrocortisone 2&#46;5&#37;&#44; which enabled her to keep the psoriasis under control&#46; She continued the treatment with infliximab and the clinical course of the HS was favourable&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><elsevierMultimedia ident="fig0010"></elsevierMultimedia><p id="par0020" class="elsevierStylePara elsevierViewall">The therapeutic management of HS is a challenge for the dermatologist&#46; Several treatments have shown mixed results and none of them has been fully effective&#46; Local treatments include antiseptic washes&#44; topical antibiotics&#44; and intralesional corticosteroid injections&#46; Systemic treatments include oral retinoids&#44; antibiotics such as minocycline or combined clindamycin and rifampicin&#44; contraceptives alone or in combination with an antiandrogen&#44; cycles of oral corticosteroids&#44; and sulfone&#46; Surgery&#44; laser hair removal&#44; photodynamic therapy&#44; and even radiation therapy have also shown some efficacy&#46;<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a></p><p id="par0025" class="elsevierStylePara elsevierViewall">Recently&#44; anti-TNF-&#945; agents have shown good results in moderate to severe HS that is poorly controlled by conventional treatments&#46;<a class="elsevierStyleCrossRefs" href="#bib0010"><span class="elsevierStyleSup">2&#8211;4</span></a> These drugs are used for inflammatory diseases in which TNF-&#945; is involved&#44; such as inflammatory bowel disease&#44; rheumatoid arthritis&#44; ankylosing spondylitis&#44; and psoriasis&#46; Inflammatory bowel disease has been associated with an increased risk of developing HS&#46;<a class="elsevierStyleCrossRef" href="#bib0045"><span class="elsevierStyleSup">9</span></a> Moreover&#44; the risk of developing psoriasis is of 6&#37; to 11&#37; in patients with inflammatory bowel disease&#44; a higher risk than in the general population&#46;<a class="elsevierStyleCrossRefs" href="#bib0025"><span class="elsevierStyleSup">5&#44;6</span></a> Smoking&#44; treatment with lithium salts&#44; and obesity are aggravating factors for both HS and psoriasis&#46;<a class="elsevierStyleCrossRefs" href="#bib0005"><span class="elsevierStyleSup">1&#44;9</span></a> In addition&#44; TNF-&#945; has been implicated in the pathophysiology of both diseases&#46; Elevated levels of TNF-&#945;&#44; IL-10&#44; and IL-1&#946; have recently been reported in patients with HS&#44; which would explain the good response to these drugs<a class="elsevierStyleCrossRef" href="#bib0050"><span class="elsevierStyleSup">10</span></a>&#59; however&#44; not all patients with HS respond to anti-TNF-&#945; agents and most do so only partially&#46;<a class="elsevierStyleCrossRefs" href="#bib0010"><span class="elsevierStyleSup">2&#8211;4</span></a> Furthermore&#44; HS lesions are often superinfected by microorganisms and there is a theoretical risk of dissemination of the infection with anti-TNF-&#945; agents&#46;</p><p id="par0030" class="elsevierStylePara elsevierViewall">Though anti-TNF-&#945; agents are indicated for the treatment of moderate and severe forms of psoriasis&#44; the possibility of paradoxical phenomena&#44; such as the onset or exacerbation of psoriasis&#44; is recognized with all of them &#40;infliximab&#44; etanercept&#44; and adalimumab&#41;&#46;<a class="elsevierStyleCrossRefs" href="#bib0025"><span class="elsevierStyleSup">5&#8211;8</span></a> Outbreaks of psoriasis associated with this drug usually appear as palmoplantar&#44; pustular&#44; or plaque-type psoriasis and more rarely as inverse psoriasis&#44; as in our patient&#46;<a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">6</span></a> The time of onset varies from 4 months to several years after the start of treatment&#46;<a class="elsevierStyleCrossRefs" href="#bib0035"><span class="elsevierStyleSup">7&#44;8</span></a> Depending on the severity of the psoriasis symptoms&#44; the anti-TNF-&#945; agent can be maintained or replaced by another immunosuppressant&#46; In 85&#37; of cases&#44; the change to another anti-TNF-&#945; agent does not solve the occurrence of psoriasis&#44; which is therefore considered a class effect&#46;<a class="elsevierStyleCrossRef" href="#bib0040"><span class="elsevierStyleSup">8</span></a> The mechanism by which psoriasis occurs in patients treated with anti-TNF-&#945; agents is unknown&#46; It has been suggested that the decreased TNF-&#945; causes an increase in interferon &#945;&#44; which in some patients leads to the development and worsening of psoriasis lesions&#44; but further studies are needed to confirm this hypothesis&#46;<a class="elsevierStyleCrossRefs" href="#bib0040"><span class="elsevierStyleSup">8&#44;10</span></a> By contrast&#44; interferon &#945; levels are decreased in HS&#46;<a class="elsevierStyleCrossRef" href="#bib0050"><span class="elsevierStyleSup">10</span></a> This finding would explain the good response of HS to treatment with infliximab and the onset of psoriasis in our patient&#46;</p><p id="par0035" class="elsevierStylePara elsevierViewall">We stress the importance of this case because it is the first published case of the appearance of psoriasis in a patient with HS treated with an anti-TNF-&#945; agent &#40;infliximab&#41;&#44; because it had an atypical presentation as flexural or inverse psoriasis&#44; and because it showed a good response to treatment with only topical corticosteroids&#44; without the need to interrupt the infliximab prescribed to treat the underlying disease&#46;</p><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">Conflicts of Interests</span><p id="par0040" class="elsevierStylePara elsevierViewall">Drs&#46; Almudena Gonz&#225;lez and Carlos Nu&#241;o-Ricotti declare that they have no conflicts of interest&#46;</p><p id="par0045" class="elsevierStylePara elsevierViewall">Dr&#46; Luis Dehesa has participated in conferences for Abbott&#44; Pfizer&#44; and Astellas&#46;</p><p id="par0050" class="elsevierStylePara elsevierViewall">Dr&#46; Francisco Kerdel has participated in conferences and studies for Amgen&#44; Abbott&#44; Jansen&#44; Schering-Plough&#44; Pfizer&#44; and Eisai&#46;</p></span></span>"
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                    0 => array:2 [
                      "titulo" => "Manejo pr&#225;ctico de la hidrosadenitis supurativa"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "J&#46; Pedraz"
                            1 => "E&#46; Daud&#233;n"
                          ]
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                  "host" => array:1 [
                    0 => array:1 [
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                        "tituloSerie" => "Actas Dermosifiliogr"
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                        "paginaInicial" => "101"
                        "paginaFinal" => "110"
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                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18346431"
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                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Infliximab therapy for patients with moderate to severe hidradenitis suppurativa&#58; a randomized&#44; double-blind&#44; placebo-controlled crossover trial"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "A&#46; Grant"
                            1 => "T&#46; Gonz&#225;lez"
                            2 => "M&#46;O&#46; Montgomery"
                            3 => "V&#46; C&#225;rdenas"
                            4 => "F&#46;A&#46; Kerdel"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.jaad.2009.06.050"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Am Acad Dermatol"
                        "fecha" => "2010"
                        "volumen" => "62"
                        "paginaInicial" => "205"
                        "paginaFinal" => "217"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/20115947"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
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              "identificador" => "bib0015"
              "etiqueta" => "3"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Hidrosadenitis supurativa&#46; Respuesta al tratamiento con infliximab"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "J&#46; Pedraz"
                            1 => "E&#46; Daud&#233;n"
                            2 => "S&#46; P&#233;rez-Gala"
                            3 => "R&#46; Goiriz-Vald&#233;s"
                            4 => "P&#46; Fern&#225;ndez-Pe&#241;as"
                            5 => "A&#46; Garc&#237;a-D&#237;ez"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Actas Dermosifiliogr"
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                        "paginaInicial" => "325"
                        "paginaFinal" => "331"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17555675"
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                  ]
                ]
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                            4 => "D&#46;N&#46; Dufour"
                            5 => "G&#46;B&#46; Jemec"
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                        "paginaInicial" => "391"
                        "paginaFinal" => "398"
                        "link" => array:1 [
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                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/21457202"
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                            4 => "Y&#46; Kohgo"
                            5 => "H&#46; Iizuka"
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                        "tituloSerie" => "J Dermatol"
                        "fecha" => "2007"
                        "volumen" => "34"
                        "paginaInicial" => "468"
                        "paginaFinal" => "472"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17584325"
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                          ]
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                    ]
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                ]
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                          "etal" => false
                          "autores" => array:4 [
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                            3 => "J&#46; Garc&#237;a-Silva"
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                        "tituloSerie" => "An Pediatr &#40;Barc&#41;"
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