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The patient had no other symptoms&#46; Of note in her past medical history was a cadaveric orthotopic kidney transplant in 2005 for chronic kidney failure of unknown etiology&#46; Since that time she had been on immunosuppressive treatment with oral corticosteroids&#44; tacrolimus&#44; and mycophenolate mofetil&#46;</p><p id="par0015" class="elsevierStylePara elsevierViewall">Physical examination revealed a very painful&#44; irregular ulcer of 4<span class="elsevierStyleHsp" style=""></span>&#215;<span class="elsevierStyleHsp" style=""></span>1&#46;5<span class="elsevierStyleHsp" style=""></span>cm on the left labium minus&#46; The base of the ulcer was soft and erythematous and was covered with areas of adherent whitish pseudomembrane &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>&#41;&#46; There were no palpable regional lymph nodes&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><p id="par0020" class="elsevierStylePara elsevierViewall">Skin biopsy showed a superficial material formed of fibrin and white blood cells and deeper in the tissue there were numerous granulomas &#40;<a class="elsevierStyleCrossRef" href="#fig0010">Fig&#46; 2</a>&#41;&#44; some with a necrotic center of caseous appearance&#44; epithelioid cells&#44; and Langhans-type multinucleated giant cells &#40;<a class="elsevierStyleCrossRef" href="#fig0015">Fig&#46; 3</a>&#41;&#46; No acid-alcohol-fast bacilli were observed with Ziehl-Neelsen stain&#46; These findings were compatible with a diagnosis of ulceration with tuberculoid granulomas&#46;</p><elsevierMultimedia ident="fig0010"></elsevierMultimedia><elsevierMultimedia ident="fig0015"></elsevierMultimedia><p id="par0025" class="elsevierStylePara elsevierViewall">Given the presence of tuberculoid granulomas and ulceration&#44; a request was made for screening for mycobacteria in the exudate from the ulcer and in the urine obtained by catheterization&#46; Study of the exudate from the ulcer by polymerase chain reaction &#40;PCR&#41; was weakly positive&#46; Ziehl-Neelsen stain of the sample taken from the skin was negative&#44; but it was positive on the urine&#46; Cultures of samples from both sites in Middlebrook 7H9 liquid medium were positive after an adequate incubation time&#46; The microorganism isolated was identified as <span class="elsevierStyleItalic">M tuberculosis</span> using DNA hybridization probes&#46;</p><p id="par0030" class="elsevierStylePara elsevierViewall">The study was completed by hysteroscopy&#44; chest x-ray&#44; abdominal ultrasound&#44; and abdominal computed tomography&#59; there were no signs of active or residual tuberculosis&#46; The tuberculin skin test was negative&#46; Based on these results&#44; a diagnosis was made of vulvar tuberculosis cutis orificialis secondary to auto-inoculation from a urinary focus&#46;</p><p id="par0035" class="elsevierStylePara elsevierViewall">The patient was immediately started on treatment with isoniazid at a dosage of 250<span class="elsevierStyleHsp" style=""></span>mg&#47;d&#44; rifampicin&#44; 600<span class="elsevierStyleHsp" style=""></span>mg&#47;d&#44; pyrazinamide&#44; 1500<span class="elsevierStyleHsp" style=""></span>mg&#47;d&#44; and ethambutol&#44; 800<span class="elsevierStyleHsp" style=""></span>mg&#47;d&#44; which were continued for 2 months&#59; she was subsequently treated for a further 4 months with only isoniazid and rifampicin&#46; The clinical course was favorable with the treatment administered&#46;</p><p id="par0040" class="elsevierStylePara elsevierViewall">There is a high prevalence of tuberculosis in Spain &#40;16&#46;96 cases&#47;100&#160;000 population in 2009 according to the Spanish Network for Epidemiological Monitoring&#44; and 30&#47;100&#160;000 population in 2007 according to the World Health Organization&#41;&#46;<a class="elsevierStyleCrossRef" href="#bib0020"><span class="elsevierStyleSup">4</span></a> The most common variant of cutaneous tuberculosis is lupus vulgaris&#46;<a class="elsevierStyleCrossRef" href="#bib0025"><span class="elsevierStyleSup">5</span></a> Tuberculosis cutis orificialis is a rare variant and accounts for only 2&#37; of cases of cutaneous tuberculosis&#46; It occurs mainly in immunosuppressed individuals&#44;<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a> and the majority of patients are middle-aged men&#46;<a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">6</span></a></p><p id="par0045" class="elsevierStylePara elsevierViewall">This clinical form affects the oral&#44; perianal&#44; or genital mucosas and the periorificial skin after auto-inoculation of the bacillus&#44; which is derived from a pulmonary&#44; intestinal&#44; or genitourinary focus by direct spread&#46; The lesions mainly occur in traumatized areas&#46; Lymphocytic or hematogenous dissemination and the involvement of adjacent organs is rare&#46;<a class="elsevierStyleCrossRefs" href="#bib0010"><span class="elsevierStyleSup">2&#44;3</span></a> The disease is defined clinically by yellowish papules or nodules that rapidly ulcerate&#44; giving rise to very painful&#44; punched-out ulcers with a granular base covered by a whitish pseudomembranous material&#46; Histology of the lesions will show tuberculoid granulomas&#46; Culture and the tuberculin skin test are usually positive&#46;<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">7</span></a></p><p id="par0050" class="elsevierStylePara elsevierViewall">Untreated&#44; the disease can be fatal within a few months&#44; due to miliary dissemination of the bacillus&#46;<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a></p><p id="par0055" class="elsevierStylePara elsevierViewall">The diagnosis of tuberculosis cutis orificialis requires the correlation of clinical&#44; histopathological&#44; and microbiological findings&#46; Conventional mycobacterial culture continues to be the most reliable method for confirming the presence of mycobacteria and their antibiotic sensitivity&#44; as well as for monitoring treatment&#59; however&#44; it has the disadvantage of a long delay until the results are available&#46;<a class="elsevierStyleCrossRef" href="#bib0040"><span class="elsevierStyleSup">8</span></a> PCR testing is a powerful tool for the diagnosis of cutaneous tuberculosis&#44; as it is rapid&#44; reliable&#44; and very sensitive&#46;<a class="elsevierStyleCrossRef" href="#bib0045"><span class="elsevierStyleSup">9</span></a></p><p id="par0060" class="elsevierStylePara elsevierViewall">The differential diagnosis of ulcerated genitourinary lesions similar to those presented includes Lipsch&#252;tz ulcer&#44; herpes simplex&#44; tumors&#44; pyoderma gangrenosum&#44; sarcoidosis&#44; chancroid&#44; syphilis&#44; lymphogranuloma venereum&#44; tuberculosis&#44; leishmaniasis&#44; and the deep mycoses&#46;<a class="elsevierStyleCrossRefs" href="#bib0015"><span class="elsevierStyleSup">3&#44;10</span></a></p><p id="par0065" class="elsevierStylePara elsevierViewall">Cutaneous tuberculosis&#44; including the periorificial form&#44; is treated using the standard treatment regimens for pulmonary tuberculosis&#46;<a class="elsevierStyleCrossRefs" href="#bib0035"><span class="elsevierStyleSup">7&#44;8</span></a></p></span>"
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        "texto" => "<p id="par0070" class="elsevierStylePara elsevierViewall">We would like to thank Dr Jos&#233; Luis Parra Mart&#237;nez for his accurate initial diagnosis made at his private pathology laboratory&#44; and for supplying us with the fixed histological specimen to complete the study&#46;</p>"
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Case and research letter
Periorificial Cutaneous Tuberculosis of the Vulva
Tuberculosis cutánea periorificial vulvar
D. Jiménez-Galloa,
Autor para correspondencia
davidjimenezgallo@gmail.com

Corresponding author.
, N. Navas-Garcíab, C. Albarrán-Planellesa, F. Guerrero-Sánchezc
a Unidad de Gestión Clínica de Dermatología Médico-Quirúrgica y Venereología, Hospital Universitario Puerta del Mar, Cádiz, Spain
b Unidad de Gestión Clínica de Anatomía Patológica, Hospital Universitario Puerta del Mar, Cádiz, Spain
c Unidad de Gestión Clínica de Medicina Interna, Hospital Universitario Puerta del Mar, Cádiz, Spain
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    "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">Periorificial cutaneous tuberculosis&#44; or tuberculosis cutis orificialis&#44; accounts for approximately 2&#37; of cases of tuberculosis of the skin&#46;<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a> It results from the auto-inoculation of <span class="elsevierStyleItalic">Mycobacterium tuberculosis</span> into the periorificial oropharyngeal&#44; anal&#44; or genital skin or mucosa from a pulmonary&#44; intestinal&#44; or genitourinary focus&#44; respectively&#46;<a class="elsevierStyleCrossRefs" href="#bib0010"><span class="elsevierStyleSup">2&#44;3</span></a> The definitive diagnosis is made by the isolation of <span class="elsevierStyleItalic">M tuberculosis</span> from the ulcer and detection of the focus of mycobacterial infection responsible for the disease&#46;</p><p id="par0010" class="elsevierStylePara elsevierViewall">The patient was a 78-year-old woman who was referred to our outpatient clinic for mild vulvar bleeding and a long-standing painful ulcer of the labia minora of the vulva&#46; The patient had no other symptoms&#46; Of note in her past medical history was a cadaveric orthotopic kidney transplant in 2005 for chronic kidney failure of unknown etiology&#46; Since that time she had been on immunosuppressive treatment with oral corticosteroids&#44; tacrolimus&#44; and mycophenolate mofetil&#46;</p><p id="par0015" class="elsevierStylePara elsevierViewall">Physical examination revealed a very painful&#44; irregular ulcer of 4<span class="elsevierStyleHsp" style=""></span>&#215;<span class="elsevierStyleHsp" style=""></span>1&#46;5<span class="elsevierStyleHsp" style=""></span>cm on the left labium minus&#46; The base of the ulcer was soft and erythematous and was covered with areas of adherent whitish pseudomembrane &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>&#41;&#46; There were no palpable regional lymph nodes&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><p id="par0020" class="elsevierStylePara elsevierViewall">Skin biopsy showed a superficial material formed of fibrin and white blood cells and deeper in the tissue there were numerous granulomas &#40;<a class="elsevierStyleCrossRef" href="#fig0010">Fig&#46; 2</a>&#41;&#44; some with a necrotic center of caseous appearance&#44; epithelioid cells&#44; and Langhans-type multinucleated giant cells &#40;<a class="elsevierStyleCrossRef" href="#fig0015">Fig&#46; 3</a>&#41;&#46; No acid-alcohol-fast bacilli were observed with Ziehl-Neelsen stain&#46; These findings were compatible with a diagnosis of ulceration with tuberculoid granulomas&#46;</p><elsevierMultimedia ident="fig0010"></elsevierMultimedia><elsevierMultimedia ident="fig0015"></elsevierMultimedia><p id="par0025" class="elsevierStylePara elsevierViewall">Given the presence of tuberculoid granulomas and ulceration&#44; a request was made for screening for mycobacteria in the exudate from the ulcer and in the urine obtained by catheterization&#46; Study of the exudate from the ulcer by polymerase chain reaction &#40;PCR&#41; was weakly positive&#46; Ziehl-Neelsen stain of the sample taken from the skin was negative&#44; but it was positive on the urine&#46; Cultures of samples from both sites in Middlebrook 7H9 liquid medium were positive after an adequate incubation time&#46; The microorganism isolated was identified as <span class="elsevierStyleItalic">M tuberculosis</span> using DNA hybridization probes&#46;</p><p id="par0030" class="elsevierStylePara elsevierViewall">The study was completed by hysteroscopy&#44; chest x-ray&#44; abdominal ultrasound&#44; and abdominal computed tomography&#59; there were no signs of active or residual tuberculosis&#46; The tuberculin skin test was negative&#46; Based on these results&#44; a diagnosis was made of vulvar tuberculosis cutis orificialis secondary to auto-inoculation from a urinary focus&#46;</p><p id="par0035" class="elsevierStylePara elsevierViewall">The patient was immediately started on treatment with isoniazid at a dosage of 250<span class="elsevierStyleHsp" style=""></span>mg&#47;d&#44; rifampicin&#44; 600<span class="elsevierStyleHsp" style=""></span>mg&#47;d&#44; pyrazinamide&#44; 1500<span class="elsevierStyleHsp" style=""></span>mg&#47;d&#44; and ethambutol&#44; 800<span class="elsevierStyleHsp" style=""></span>mg&#47;d&#44; which were continued for 2 months&#59; she was subsequently treated for a further 4 months with only isoniazid and rifampicin&#46; The clinical course was favorable with the treatment administered&#46;</p><p id="par0040" class="elsevierStylePara elsevierViewall">There is a high prevalence of tuberculosis in Spain &#40;16&#46;96 cases&#47;100&#160;000 population in 2009 according to the Spanish Network for Epidemiological Monitoring&#44; and 30&#47;100&#160;000 population in 2007 according to the World Health Organization&#41;&#46;<a class="elsevierStyleCrossRef" href="#bib0020"><span class="elsevierStyleSup">4</span></a> The most common variant of cutaneous tuberculosis is lupus vulgaris&#46;<a class="elsevierStyleCrossRef" href="#bib0025"><span class="elsevierStyleSup">5</span></a> Tuberculosis cutis orificialis is a rare variant and accounts for only 2&#37; of cases of cutaneous tuberculosis&#46; It occurs mainly in immunosuppressed individuals&#44;<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a> and the majority of patients are middle-aged men&#46;<a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">6</span></a></p><p id="par0045" class="elsevierStylePara elsevierViewall">This clinical form affects the oral&#44; perianal&#44; or genital mucosas and the periorificial skin after auto-inoculation of the bacillus&#44; which is derived from a pulmonary&#44; intestinal&#44; or genitourinary focus by direct spread&#46; The lesions mainly occur in traumatized areas&#46; Lymphocytic or hematogenous dissemination and the involvement of adjacent organs is rare&#46;<a class="elsevierStyleCrossRefs" href="#bib0010"><span class="elsevierStyleSup">2&#44;3</span></a> The disease is defined clinically by yellowish papules or nodules that rapidly ulcerate&#44; giving rise to very painful&#44; punched-out ulcers with a granular base covered by a whitish pseudomembranous material&#46; Histology of the lesions will show tuberculoid granulomas&#46; Culture and the tuberculin skin test are usually positive&#46;<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">7</span></a></p><p id="par0050" class="elsevierStylePara elsevierViewall">Untreated&#44; the disease can be fatal within a few months&#44; due to miliary dissemination of the bacillus&#46;<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a></p><p id="par0055" class="elsevierStylePara elsevierViewall">The diagnosis of tuberculosis cutis orificialis requires the correlation of clinical&#44; histopathological&#44; and microbiological findings&#46; Conventional mycobacterial culture continues to be the most reliable method for confirming the presence of mycobacteria and their antibiotic sensitivity&#44; as well as for monitoring treatment&#59; however&#44; it has the disadvantage of a long delay until the results are available&#46;<a class="elsevierStyleCrossRef" href="#bib0040"><span class="elsevierStyleSup">8</span></a> PCR testing is a powerful tool for the diagnosis of cutaneous tuberculosis&#44; as it is rapid&#44; reliable&#44; and very sensitive&#46;<a class="elsevierStyleCrossRef" href="#bib0045"><span class="elsevierStyleSup">9</span></a></p><p id="par0060" class="elsevierStylePara elsevierViewall">The differential diagnosis of ulcerated genitourinary lesions similar to those presented includes Lipsch&#252;tz ulcer&#44; herpes simplex&#44; tumors&#44; pyoderma gangrenosum&#44; sarcoidosis&#44; chancroid&#44; syphilis&#44; lymphogranuloma venereum&#44; tuberculosis&#44; leishmaniasis&#44; and the deep mycoses&#46;<a class="elsevierStyleCrossRefs" href="#bib0015"><span class="elsevierStyleSup">3&#44;10</span></a></p><p id="par0065" class="elsevierStylePara elsevierViewall">Cutaneous tuberculosis&#44; including the periorificial form&#44; is treated using the standard treatment regimens for pulmonary tuberculosis&#46;<a class="elsevierStyleCrossRefs" href="#bib0035"><span class="elsevierStyleSup">7&#44;8</span></a></p></span>"
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                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Tuberculosis cut&#225;nea"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "O&#46;W&#46; Tincopa-Wong"
                            1 => "L&#46; S&#225;nchez-Salda&#241;a"
                          ]
                        ]
                      ]
                    ]
                  ]
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        "identificador" => "xack35264"
        "titulo" => "Acknowledgments"
        "texto" => "<p id="par0070" class="elsevierStylePara elsevierViewall">We would like to thank Dr Jos&#233; Luis Parra Mart&#237;nez for his accurate initial diagnosis made at his private pathology laboratory&#44; and for supplying us with the fixed histological specimen to complete the study&#46;</p>"
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ISSN: 15782190
Idioma original: Inglés
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