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were observed using standard histochemical staining techniques &#40;<a class="elsevierStyleCrossRef" href="#fig0015">Fig&#46; 3</a>&#41;&#46;</p><elsevierMultimedia ident="fig0010"></elsevierMultimedia><elsevierMultimedia ident="fig0015"></elsevierMultimedia></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">Additional Tests</span><p id="par0020" class="elsevierStylePara elsevierViewall">Culture of the exudate revealed <span class="elsevierStyleItalic">Staphylococcus aureus</span> and <span class="elsevierStyleItalic">Streptococcus equisimilis</span>&#46; Radiographs of the chest&#44; foot&#44; and ankle were normal&#46; Serology showed evidence of past infection with hepatitis B virus but was negative for human immunodeficiency virus&#46; Other laboratory tests&#44; including complete blood count&#44; coagulation studies&#44; biochemistry&#44; liver and kidney function tests&#44; and serology&#44; were normal or negative&#46;</p><p id="par0025" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleBold">What Is Your Diagnosis&#63;</span></p></span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">Diagnosis</span><p id="par0030" class="elsevierStylePara elsevierViewall">Primary cutaneous botryomycosis&#46;</p></span><span id="sec0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">Clinical Course</span><p id="par0035" class="elsevierStylePara elsevierViewall">Treatment was started with oral amoxicillin &#40;1<span class="elsevierStyleHsp" style=""></span>g&#47;8<span class="elsevierStyleHsp" style=""></span>h&#41; 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similar to that of chronic pyoderma&#44; takes the form of a single lesion&#44; which commonly affects exposed areas&#46;<a class="elsevierStyleCrossRefs" href="#bib0005"><span class="elsevierStyleSup">1-3</span></a> The skin is the most frequently affected organ&#46;<a class="elsevierStyleCrossRefs" href="#bib0010"><span class="elsevierStyleSup">2-4</span></a> The main causative agent is <span class="elsevierStyleItalic">S aureus</span>&#44; followed by <span class="elsevierStyleItalic">Pseudomonas aeruginosa</span>&#44; but the infection is polymicrobial in up to 50&#37; of cases&#46;<a class="elsevierStyleCrossRefs" href="#bib0035"><span class="elsevierStyleSup">7&#44;8</span></a></p><p id="par0055" class="elsevierStylePara elsevierViewall">The pathogenesis of the disease remains a subject of debate&#46; It has been suggested that a balance between the number of microorganisms and the host&#39;s defences is necessary&#44; as high concentrations of bacterial inoculum would cause extensive and rapid tissue necrosis&#44; whereas low concentrations would cause the organisms to be phagocytized&#46;<a class="elsevierStyleCrossRefs" href="#bib0005"><span class="elsevierStyleSup">1-8</span></a></p><p id="par0060" class="elsevierStylePara elsevierViewall">Definitive diagnosis is based on histologic and microbiological criteria<a class="elsevierStyleCrossRefs" href="#bib0005"><span class="elsevierStyleSup">1-8</span></a> and is considerably aided by the study of the shape and characteristics of the granule for differentiation from actinomycosis and mycetoma &#40;where granules are filamentous and change color rapidly with fungal stains&#41;&#46; These studies also show the Splendore-Hoeppli phenomenon&#44; when present&#46; This phenomenon is highly characteristic of the disease and consists of periodic acid-Schiff&#8211;positive basophilic granules &#40;clusters of bacteria&#41;&#44; surrounded by eosinophilic material &#40;immunoglobulin deposits&#41;&#44; a reflection of the host&#39;s immune response&#46;<a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">6</span></a></p><p id="par0065" class="elsevierStylePara elsevierViewall">Administration of specific antibiotics for long periods forms the basis of treatment&#46;<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a> Surgery is recommended when faster healing is required or there is only partial response to antibiotic treatment&#46;<a class="elsevierStyleCrossRefs" href="#bib0005"><span class="elsevierStyleSup">1-6</span></a></p><p id="par0070" class="elsevierStylePara elsevierViewall">Most cases in the literature describe patients with an abnormal immune function or significant comorbidities&#44;<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a> but this was not true for our patient&#46; Our patient had regularly walked barefoot in Senegal&#44; a fact that&#44; coupled with chronic malnutrition and irregular antibiotic treatment&#44; could have contributed to the development and perpetuation of the disease&#46;</p></span></span>"
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Cases for Diagnosis
Chronic Plantar Ulcer in an Immigrant from Africa
Úlcera plantar crónica en inmigrante africano
A. Molina-Ruiza,
Autor para correspondencia
anamaria.molinaruiz@gmail.com

Corresponding author.
, E. Pérez-Vegab, T. Zulueta-Doradoc
a Servicio de Dermatología, Fundación Jiménez Díaz, Madrid, Spain
b Servicio de Dermatología, Hospital Virgen del Rocío, Sevilla, Spain
c Servicio de Anatomía Patológica, Hospital Virgen del Rocío, Sevilla, Spain
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were observed using standard histochemical staining techniques &#40;<a class="elsevierStyleCrossRef" href="#fig0015">Fig&#46; 3</a>&#41;&#46;</p><elsevierMultimedia ident="fig0010"></elsevierMultimedia><elsevierMultimedia ident="fig0015"></elsevierMultimedia></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">Additional Tests</span><p id="par0020" class="elsevierStylePara elsevierViewall">Culture of the exudate revealed <span class="elsevierStyleItalic">Staphylococcus aureus</span> and <span class="elsevierStyleItalic">Streptococcus equisimilis</span>&#46; Radiographs of the chest&#44; foot&#44; and ankle were normal&#46; Serology showed evidence of past infection with hepatitis B virus but was negative for human immunodeficiency virus&#46; Other laboratory tests&#44; including complete blood count&#44; coagulation studies&#44; biochemistry&#44; liver and kidney function tests&#44; and serology&#44; were normal or negative&#46;</p><p id="par0025" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleBold">What Is Your Diagnosis&#63;</span></p></span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">Diagnosis</span><p id="par0030" class="elsevierStylePara elsevierViewall">Primary cutaneous botryomycosis&#46;</p></span><span id="sec0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">Clinical Course</span><p id="par0035" class="elsevierStylePara elsevierViewall">Treatment was started with oral amoxicillin &#40;1<span class="elsevierStyleHsp" style=""></span>g&#47;8<span class="elsevierStyleHsp" style=""></span>h&#41; 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similar to that of chronic pyoderma&#44; takes the form of a single lesion&#44; which commonly affects exposed areas&#46;<a class="elsevierStyleCrossRefs" href="#bib0005"><span class="elsevierStyleSup">1-3</span></a> The skin is the most frequently affected organ&#46;<a class="elsevierStyleCrossRefs" href="#bib0010"><span class="elsevierStyleSup">2-4</span></a> The main causative agent is <span class="elsevierStyleItalic">S aureus</span>&#44; followed by <span class="elsevierStyleItalic">Pseudomonas aeruginosa</span>&#44; but the infection is polymicrobial in up to 50&#37; of cases&#46;<a class="elsevierStyleCrossRefs" href="#bib0035"><span class="elsevierStyleSup">7&#44;8</span></a></p><p id="par0055" class="elsevierStylePara elsevierViewall">The pathogenesis of the disease remains a subject of debate&#46; It has been suggested that a balance between the number of microorganisms and the host&#39;s defences is necessary&#44; as high concentrations of bacterial inoculum would cause extensive and rapid tissue necrosis&#44; 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ISSN: 15782190
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