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the National Comprehensive Cancer Network recommends the use of these techniques whenever possible&#46;</p><p id="par0010" class="elsevierStylePara elsevierViewall">Our first patient was an 84-year-old woman who presented an irregularly pigmented lesion of 2&#46;5<span class="elsevierStyleHsp" style=""></span>cm that had been present for 4 years on her left cheek&#59; biopsy confirmed LM&#46; The so-called spaghetti technique &#40;initial delimitation of the perimeter of the lesion&#41; &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>&#41; was chosen&#46; This technique consists of the excision of a strip of tissue with a breadth of about 3<span class="elsevierStyleHsp" style=""></span>mm around the perimeter of the lesion&#59; the wound is then sutured and the patient can go home with a closed wound to await the histology report &#40;<a class="elsevierStyleCrossRef" href="#fig0010">Fig&#46; 2</a>&#41;&#46; The specimen is fixed in formol by sectors and marked so that the pathologist can process it as usual and take vertical sections after embedding the tissue in paraffin&#46; If necessary&#44; based on findings&#44; the surgical margins can be enlarged until free margins are achieved&#46; Complete excision of the lesion is then performed&#44; with closure of the defect using a flap if indicated&#46; In this patient&#44; free margins were achieved with excision of the first strip of tissue and complete excision of the lesion could be performed the following week&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><elsevierMultimedia ident="fig0010"></elsevierMultimedia><p id="par0015" class="elsevierStylePara elsevierViewall">Our second patient was a 69-year-old man with a 2-cm LM on the forehead&#46; In this case&#44; a polygonal excision was designed to match the outline of the lesion and the skinfolds of the forehead &#40;<a class="elsevierStyleCrossRef" href="#fig0015">Fig&#46; 3</a>&#41;&#46; It was necessary to extend the margin in the superior zone in a second operation &#40;<a class="elsevierStyleCrossRef" href="#fig0015">Fig&#46; 3</a>B&#41;&#46; Complete excision of the lesion and closure of the defect was performed 20 days after the first operation&#46;</p><elsevierMultimedia ident="fig0015"></elsevierMultimedia><p id="par0020" class="elsevierStylePara elsevierViewall">The spaghetti technique is not new&#44; but rather the further development of an idea proposed by Johnson in 1997 and that envisaged a different strategy in the treatment of LM&#46; First the surgical margins of the LM are established&#44; as if the lesion was a picture and we are drawing its frame&#46; Next&#44; the lesion is then removed with full assurance that excision is complete&#46;<a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">6</span></a> The initial proposal involved a square or polygonal excision to facilitate the cutting and orientation of the surgical specimen&#44; but depending on the site of the lesion&#44; rounded or polygonal forms are now possible with the use of photographs or marker sutures to indicate the orientation of the specimen&#46;<a class="elsevierStyleCrossRefs" href="#bib0035"><span class="elsevierStyleSup">7-9</span></a> It is a simple technique that can be performed by any dermatologist&#46;</p><p id="par0025" class="elsevierStylePara elsevierViewall">Mohs micrographic surgery and other techniques of sequential &#40;stepped&#41; excision with the examination of sections taken from the fresh or paraffin-embedded specimen are of proven efficacy<a class="elsevierStyleCrossRefs" href="#bib0005"><span class="elsevierStyleSup">1&#44;3&#44;4&#44;10</span></a> but are only performed in specialized centers&#46; In Mohs micrographic surgery&#44; the interpretation of the frozen sections by the pathologist can be very difficult and occasionally the wound must be left open while waiting for the results of examining paraffin-embedded sections&#46;</p><p id="par0030" class="elsevierStylePara elsevierViewall">The technique described in this paper&#44; in which the initial step is to locate the margins&#44; can be very useful in treatment centers where Mohs micrographic surgery is not available or in certain circumstances&#44; such as recurrent tumors with poorly defined borders&#44; older patients or patients living at a distance from the hospital&#44; and lesions whose size means that a flap will be required to close the defect&#44; thereby distorting the margins&#46; The spaghetti technique has several advantages&#46; Routine pathology processing systems can be used and the dermatologist needs no special training&#46; No wounds are left open &#40;meaning that the patient can be discharged without the need for special measures&#41;&#44; and there is time to design the reconstruction technique according to the histological findings and the size of the defect&#44; both of which will be known before the final procedure&#46; One of the limitations of this technique is that foci of invasive malignant melanoma cells may be present within the LM&#44; and the excision must therefore reach a deep plane&#46; Another problem is that the complete excision of the lesion will be delayed by days or weeks&#44; and the reason for this must be explained to the patient&#46;</p></span>"
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Cases and Research Letters
The Perimeter Technique in the Surgical Treatment of Lentigo Maligna and Lentigo Maligna Melanoma
Técnica de delimitación del perímetro en el tratamiento quirúrgico del lentigo maligno y el lentigo maligno melanoma
B. García Bracamonte
Autor para correspondencia
beagarcia50@hotmail.com

Corresponding author.
, S.I. Palencia-Pérez, G. Petiti, F. Vanaclocha-Sebastián
Servicio de Dermatología, Hospital Universitario 12 de Octubre, Madrid, Spain
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    "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">The treatment of choice for lentigo maligna &#40;LM&#41; and for lentigo maligna melanoma &#40;LMM&#41; is still complete excision of the tumor with adequate surgical margins&#46; Conventionally&#44; surgical margins of 0&#46;5<span class="elsevierStyleHsp" style=""></span>cm for LM and of 1<span class="elsevierStyleHsp" style=""></span>cm for thin LMM with a Breslow depth<span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>1<span class="elsevierStyleHsp" style=""></span>mm have been recommended&#46; However&#44; numerous reports have demonstrated the need for wider margins&#44; as the subclinical extension of the melanocytic dysplasia in LM can be greater than predicted&#46;<a class="elsevierStyleCrossRefs" href="#bib0005"><span class="elsevierStyleSup">1-4</span></a> Techniques with 3-dimensional histological control of the margins have been found to be better than conventional surgery as they are followed by fewer recurrences&#46;<a class="elsevierStyleCrossRefs" href="#bib0020"><span class="elsevierStyleSup">4&#44;5</span></a> Since 2008&#44; the National Comprehensive Cancer Network recommends the use of these techniques whenever possible&#46;</p><p id="par0010" class="elsevierStylePara elsevierViewall">Our first patient was an 84-year-old woman who presented an irregularly pigmented lesion of 2&#46;5<span class="elsevierStyleHsp" style=""></span>cm that had been present for 4 years on her left cheek&#59; biopsy confirmed LM&#46; The so-called spaghetti technique &#40;initial delimitation of the perimeter of the lesion&#41; &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>&#41; was chosen&#46; This technique consists of the excision of a strip of tissue with a breadth of about 3<span class="elsevierStyleHsp" style=""></span>mm around the perimeter of the lesion&#59; the wound is then sutured and the patient can go home with a closed wound to await the histology report &#40;<a class="elsevierStyleCrossRef" href="#fig0010">Fig&#46; 2</a>&#41;&#46; The specimen is fixed in formol by sectors and marked so that the pathologist can process it as usual and take vertical sections after embedding the tissue in paraffin&#46; If necessary&#44; based on findings&#44; the surgical margins can be enlarged until free margins are achieved&#46; Complete excision of the lesion is then performed&#44; with closure of the defect using a flap if indicated&#46; In this patient&#44; free margins were achieved with excision of the first strip of tissue and complete excision of the lesion could be performed the following week&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><elsevierMultimedia ident="fig0010"></elsevierMultimedia><p id="par0015" class="elsevierStylePara elsevierViewall">Our second patient was a 69-year-old man with a 2-cm LM on the forehead&#46; In this case&#44; a polygonal excision was designed to match the outline of the lesion and the skinfolds of the forehead &#40;<a class="elsevierStyleCrossRef" href="#fig0015">Fig&#46; 3</a>&#41;&#46; It was necessary to extend the margin in the superior zone in a second operation &#40;<a class="elsevierStyleCrossRef" href="#fig0015">Fig&#46; 3</a>B&#41;&#46; Complete excision of the lesion and closure of the defect was performed 20 days after the first operation&#46;</p><elsevierMultimedia ident="fig0015"></elsevierMultimedia><p id="par0020" class="elsevierStylePara elsevierViewall">The spaghetti technique is not new&#44; but rather the further development of an idea proposed by Johnson in 1997 and that envisaged a different strategy in the treatment of LM&#46; First the surgical margins of the LM are established&#44; as if the lesion was a picture and we are drawing its frame&#46; Next&#44; the lesion is then removed with full assurance that excision is complete&#46;<a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">6</span></a> The initial proposal involved a square or polygonal excision to facilitate the cutting and orientation of the surgical specimen&#44; but depending on the site of the lesion&#44; rounded or polygonal forms are now possible with the use of photographs or marker sutures to indicate the orientation of the specimen&#46;<a class="elsevierStyleCrossRefs" href="#bib0035"><span class="elsevierStyleSup">7-9</span></a> It is a simple technique that can be performed by any dermatologist&#46;</p><p id="par0025" class="elsevierStylePara elsevierViewall">Mohs micrographic surgery and other techniques of sequential &#40;stepped&#41; excision with the examination of sections taken from the fresh or paraffin-embedded specimen are of proven efficacy<a class="elsevierStyleCrossRefs" href="#bib0005"><span class="elsevierStyleSup">1&#44;3&#44;4&#44;10</span></a> but are only performed in specialized centers&#46; In Mohs micrographic surgery&#44; the interpretation of the frozen sections by the pathologist can be very difficult and occasionally the wound must be left open while waiting for the results of examining paraffin-embedded sections&#46;</p><p id="par0030" class="elsevierStylePara elsevierViewall">The technique described in this paper&#44; in which the initial step is to locate the margins&#44; can be very useful in treatment centers where Mohs micrographic surgery is not available or in certain circumstances&#44; such as recurrent tumors with poorly defined borders&#44; older patients or patients living at a distance from the hospital&#44; and lesions whose size means that a flap will be required to close the defect&#44; thereby distorting the margins&#46; The spaghetti technique has several advantages&#46; Routine pathology processing systems can be used and the dermatologist needs no special training&#46; No wounds are left open &#40;meaning that the patient can be discharged without the need for special measures&#41;&#44; and there is time to design the reconstruction technique according to the histological findings and the size of the defect&#44; both of which will be known before the final procedure&#46; One of the limitations of this technique is that foci of invasive malignant melanoma cells may be present within the LM&#44; and the excision must therefore reach a deep plane&#46; Another problem is that the complete excision of the lesion will be delayed by days or weeks&#44; and the reason for this must be explained to the patient&#46;</p></span>"
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